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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fluvastatin
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Accession:CHEBI:38561 term browser browse the term
Definition:A racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin. An HMG-CoA reductase inhibitor, it is used (often as the corresponding sodium salt) to reduce triglycerides and LDL-cholesterol, and increase HDL-chloesterol, in the treatment of hyperlipidaemia.
Synonyms:exact_synonym: rac-(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
 related_synonym: (6E)-erythro7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid;   Cranoc;   Formula=C24H26FNO4;   InChI=1S/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19-/m0/s1;   InChIKey=FJLGEFLZQAZZCD-JUFISIKESA-N;   SMILES=C1(=CC=C(C=C1)C=2C=3C(N(C2/C=C/[C@@H](C[C@@H](CC(O)=O)O)O)C(C)C)=CC=CC3)F;   erythro-(E)-3,5-dihydroxy-7-[3'-(4''-fluorophenyl)-1'-(1''-methylethyl)indol-2'-yl]hept-6-enoic acid;   fluvastatina;   fluvastatine;   fluvastatinum;   rac-(3R,5S)-fluvastatin;   rac-(3R,5S,6E)-7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)-3,5-dihydroxy-6-heptenoic acid
 xref: Beilstein:9168031;   CAS:93957-54-1;   DrugBank:DB01095;   KEGG:C07014;   KEGG:D07983
 xref_mesh: MESH:C065180
 xref: PMID:11273020;   PMID:12147804;   PMID:18410471;   PMID:18413661;   PMID:18452779;   PMID:18936176;   PMID:23212095;   PMID:23846727;   Patent:US4739073;   Patent:WO8402131;   Wikipedia:Fluvastatin



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fluvastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO [ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to Fluvastatin; [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to Fluvastatin CTD PMID:19773416 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO fluvastatin results in decreased activity of ABCB11 protein
fluvastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]
CTD PMID:15901796 PMID:20829430 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects transport
multiple interactions
EXP
ISO
ABCC2 protein affects the transport of fluvastatin
ABCC2 protein binds to and results in increased uptake of fluvastatin analog; fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; fluvastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]
CTD PMID:16026004 PMID:23562342 PMID:24909372 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Apob apolipoprotein B multiple interactions ISO [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin; fluvastatin promotes the reaction [[Valsartan co-treated with benazepril] results in decreased expression of APOB protein] CTD PMID:19773416 PMID:20671225 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Apoe apolipoprotein E multiple interactions
increases expression
ISO [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin
fluvastatin results in increased expression of APOE protein
CTD PMID:8017468 PMID:19773416 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Arhgap29 Rho GTPase activating protein 29 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of ARHGAP29 mRNA CTD PMID:16996129 NCBI chr 2:210,060,036...210,132,572
Ensembl chr 2:210,071,199...210,132,028
JBrowse link
G Arhgef12 Rho guanine nucleotide exchange factor 12 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of ARHGEF12 mRNA CTD PMID:16996129 NCBI chr 8:43,350,070...43,475,404
Ensembl chr 8:43,353,799...43,476,366
JBrowse link
G Arhgef3 Rho guanine nucleotide exchange factor 3 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of ARHGEF3 mRNA CTD PMID:16996129 NCBI chr16:2,301,573...2,581,951
Ensembl chr16:2,300,138...2,581,945
JBrowse link
G Bcap29 B-cell receptor-associated protein 29 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of BCAP29 mRNA CTD PMID:16996129 NCBI chr 6:48,182,702...48,222,698
Ensembl chr 6:48,182,706...48,222,720
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of BCL2L11 mRNA CTD PMID:16996129 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of BHLHE40 mRNA CTD PMID:16996129 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of BUB1 mRNA CTD PMID:16996129 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
JBrowse link
G Casp1 caspase 1 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of CASP1 mRNA CTD PMID:16996129 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions ISO fluvastatin results in increased cleavage of and results in increased activity of CASP3 protein; Mevalonic Acid inhibits the reaction [fluvastatin results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:24964743 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
ISO fluvastatin results in increased activity of CASP8 protein
Mevalonic Acid inhibits the reaction [fluvastatin results in increased activity of CASP8 protein]
CTD PMID:24964743 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cat catalase increases expression ISO fluvastatin results in increased expression of CAT protein CTD PMID:24964743 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of CCL2 mRNA] CTD PMID:16452496 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cdk2ap2 cyclin-dependent kinase 2 associated protein 2 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of CDK2AP2 mRNA CTD PMID:16996129 NCBI chr 1:201,391,056...201,393,137
Ensembl chr 1:201,391,466...201,393,137
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of CKS2 mRNA CTD PMID:16996129 NCBI chr17:13,570,611...13,575,770 JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO fluvastatin results in increased expression of CYP2B6 mRNA CTD PMID:15802384 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
multiple interactions
ISO Fluvastatin results in decreased activity of CYP3A4 protein
[Fluvastatin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA; Fluvastatin inhibits the reaction [CYP3A4 protein affects the metabolism of Midazolam]
CTD PMID:16029222 PMID:24204015 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ddb2 damage specific DNA binding protein 2 decreases expression
multiple interactions
ISO fluvastatin results in decreased expression of DDB2 mRNA; fluvastatin results in decreased expression of DDB2 protein
[fluvastatin results in decreased expression of DDB2] which results in increased expression of SOD2 mRNA; Mevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of DDB2 mRNA]; Mevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of DDB2 protein]
CTD PMID:24964743 NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
JBrowse link
G Ednra endothelin receptor type A decreases expression EXP fluvastatin results in decreased expression of EDNRA mRNA CTD PMID:28951255 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Emp3 epithelial membrane protein 3 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of EMP3 mRNA CTD PMID:16996129 NCBI chr 1:96,388,651...96,391,946
Ensembl chr 1:96,388,652...96,391,988
JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of ERCC5 mRNA CTD PMID:16996129 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472
JBrowse link
G Erg ETS transcription factor ERG multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of ERG mRNA CTD PMID:16996129 NCBI chr11:34,678,614...34,900,951
Ensembl chr11:34,678,618...34,845,871
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
decreases expression
ISO Fluvastatin inhibits the reaction [Lipopolysaccharides promotes the reaction [[REL protein binds to RELA protein] which binds to F3 promoter]]; geranylgeraniol inhibits the reaction [Fluvastatin results in decreased expression of F3 protein]; Mevalonic Acid inhibits the reaction [Fluvastatin results in decreased expression of F3 mRNA]; Mevalonic Acid inhibits the reaction [Fluvastatin results in decreased expression of F3 protein]
Fluvastatin results in decreased expression of F3 mRNA; Fluvastatin results in decreased expression of F3 protein
CTD PMID:9081680 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of FDFT1 mRNA CTD PMID:16996129 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
JBrowse link
G Fnta farnesyltransferase, CAAX box, alpha multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of FNTA mRNA CTD PMID:16996129 NCBI chr16:66,065,131...66,083,460
Ensembl chr16:66,065,132...66,083,460
JBrowse link
G Foxo1 forkhead box O1 decreases phosphorylation ISO Fluvastatin results in decreased phosphorylation of FOXO1 protein CTD PMID:33034787 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO [Fluvastatin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA CTD PMID:24204015 NCBI chr10:86,307,400...86,318,766 JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of GADD45B mRNA CTD PMID:16996129 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
decreases activity
ISO [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin
fluvastatin results in decreased activity of HMGCR protein
CTD PMID:8593127 PMID:19773416 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of IGF1 mRNA CTD PMID:16996129 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of IGFBP5 mRNA CTD PMID:16996129 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
JBrowse link
G Il10ra interleukin 10 receptor subunit alpha multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of IL10RA mRNA CTD PMID:16996129 NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP fluvastatin results in decreased expression of IL1B mRNA CTD PMID:28951255 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2rg interleukin 2 receptor subunit gamma multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of IL2RG mRNA CTD PMID:16996129 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823
JBrowse link
G Irf4 interferon regulatory factor 4 decreases expression ISO Fluvastatin results in decreased expression of IRF4 protein CTD PMID:33034787 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
JBrowse link
G Kat2b lysine acetyltransferase 2B multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of KAT2B mRNA CTD PMID:16996129 NCBI chr 9:6,562,525...6,667,064 JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases activity
ISO [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin; fluvastatin promotes the reaction [Cholesterol, LDL binds to LDLR protein]; fluvastatin promotes the reaction [Indomethacin promotes the reaction [Cholesterol, LDL binds to LDLR protein]]
fluvastatin results in increased activity of LDLR protein
CTD PMID:8593127 PMID:10395027 PMID:19773416 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Lipc lipase C, hepatic type multiple interactions ISO [ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin; [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin CTD PMID:19773416 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
JBrowse link
G Lmna lamin A/C decreases farnesylation ISO fluvastatin results in decreased farnesylation of LMNA protein CTD PMID:16996129 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO [ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin; [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin CTD PMID:19773416 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lzts1 leucine zipper tumor suppressor 1 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of LZTS1 mRNA CTD PMID:16996129 NCBI chr16:20,542,756...20,598,204
Ensembl chr16:20,542,809...20,598,203
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO fluvastatin results in decreased expression of MCL1 protein CTD PMID:16996129 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Med23 mediator complex subunit 23 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of MED23 mRNA CTD PMID:16996129 NCBI chr 1:20,490,315...20,558,461
Ensembl chr 1:20,490,315...20,537,463
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO Amitrole inhibits the reaction [fluvastatin results in decreased expression of MMP2 mRNA] CTD PMID:24964743 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO fluvastatin results in decreased expression of MMP9 mRNA
Amitrole inhibits the reaction [fluvastatin results in decreased expression of MMP9 mRNA]
CTD PMID:24964743 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mphosph8 M-phase phosphoprotein 8 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of MPHOSPH8 mRNA CTD PMID:16996129 NCBI chr15:30,800,546...30,828,415 JBrowse link
G Mstn myostatin increases expression ISO Fluvastatin results in increased expression of MSTN protein CTD PMID:33034787 NCBI chr 9:48,453,982...48,458,809
Ensembl chr 9:48,452,533...48,458,933
JBrowse link
G Ndc80 NDC80 kinetochore complex component multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of NDC80 mRNA CTD PMID:16996129 NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
ISO fluvastatin results in increased expression of NOS2 mRNA; fluvastatin results in increased expression of NOS2 protein
[[fluvastatin results in increased expression of NOS2] which results in increased abundance of Nitric Oxide] which results in decreased expression of TFRC; [fluvastatin results in increased expression of NOS2] which results in increased abundance of Nitric Oxide; [N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [fluvastatin results in increased abundance of Nitric Oxide]; Mevalonic Acid inhibits the reaction [fluvastatin results in increased expression of NOS2 protein]
CTD PMID:24964743 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP [fluvastatin co-treated with Valsartan] results in increased expression of NOS3 mRNA CTD PMID:28951255 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin increases expression ISO fluvastatin increases expression of Nphs1 protein in kidney RGD PMID:19188342 RGD:38596324 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO fluvastatin results in increased activity of NR1I2 protein
[Fluvastatin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA; [Fluvastatin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA; [Fluvastatin co-treated with NR1I2 protein] results in increased expression of SGK2 mRNA
CTD PMID:15802384 PMID:24204015 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO
EXP
fluvastatin results in increased activity of NR1I3 protein CTD PMID:15802384 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Optn optineurin multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of OPTN mRNA CTD PMID:16996129 NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251
JBrowse link
G Pals1 protein associated with LIN7 1, MAGUK p55 family member multiple interactions ISO [Zoledronic Acid co-treated with Fluvastatin] results in increased expression of PALS1 mRNA CTD PMID:16996129 NCBI chr 6:97,548,133...97,654,163
Ensembl chr 6:97,548,630...97,653,305
JBrowse link
G Pappa2 pappalysin 2 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of PAPPA2 mRNA CTD PMID:16996129 NCBI chr13:70,873,918...71,147,874
Ensembl chr13:70,876,794...71,147,779
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 multiple interactions ISO [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin CTD PMID:19773416 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
JBrowse link
G Pon1 paraoxonase 1 multiple interactions
decreases activity
EXP fluvastatin inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; fluvastatin inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]
fluvastatin results in decreased activity of PON1 protein
CTD PMID:14668577 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO fluvastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]] CTD PMID:11779144 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions EXP fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of PPP1R12A protein modified form] CTD PMID:16452496 NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of PPP1R15A mRNA CTD PMID:16996129 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of PRDX3 mRNA CTD PMID:16996129 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111
JBrowse link
G Procr protein C receptor increases expression ISO fluvastatin results in increased expression of PROCR protein CTD PMID:16142594 NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903
JBrowse link
G Rab27b RAB27B, member RAS oncogene family multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of RAB27B mRNA CTD PMID:16996129 NCBI chr18:63,597,554...63,794,124
Ensembl chr18:63,600,937...63,757,180
JBrowse link
G Rab32 RAB32, member RAS oncogene family multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of RAB32 mRNA CTD PMID:16996129 NCBI chr 1:4,946,193...4,961,003
Ensembl chr 1:4,945,036...4,960,934
JBrowse link
G Rab5b RAB5B, member RAS oncogene family multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of RAB5B mRNA CTD PMID:16996129 NCBI chr 7:1,109,449...1,128,348
Ensembl chr 7:1,109,454...1,128,268
JBrowse link
G Rabgap1l RAB GTPase activating protein 1-like multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of RABGAP1L mRNA CTD PMID:16996129 NCBI chr13:72,464,114...73,059,845
Ensembl chr13:72,468,110...73,059,984
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family decreases prenylation ISO fluvastatin results in decreased prenylation of RAP1A protein CTD PMID:16996129 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO fluvastatin results in decreased phosphorylation of RB1 protein CTD PMID:16996129 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO Fluvastatin inhibits the reaction [Lipopolysaccharides promotes the reaction [[REL protein binds to RELA protein] which binds to F3 promoter]] CTD PMID:9081680 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Fluvastatin inhibits the reaction [Lipopolysaccharides promotes the reaction [[REL protein binds to RELA protein] which binds to F3 promoter]] CTD PMID:9081680 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rgs11 regulator of G-protein signaling 11 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of RGS11 mRNA CTD PMID:16996129 NCBI chr10:15,222,803...15,231,060
Ensembl chr10:15,222,803...15,231,060
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO
EXP
fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of RHOA protein] CTD PMID:16452496 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rhob ras homolog family member B multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of RHOB mRNA CTD PMID:16996129 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of RIMS2 mRNA CTD PMID:16996129 NCBI chr 7:70,248,104...70,759,134
Ensembl chr 7:70,243,872...70,757,491
JBrowse link
G Rin2 Ras and Rab interactor 2 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of RIN2 mRNA CTD PMID:16996129 NCBI chr 3:133,086,858...133,303,604
Ensembl chr 3:133,086,749...133,303,604
JBrowse link
G RT1-Ba RT1 class II, locus Ba affects expression ISO fluvastatin affects the expression of HLA-DQA1 mRNA CTD PMID:25811541 NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO fluvastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]] CTD PMID:11779144 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 affects expression EXP fluvastatin affects the expression of SGK1 mRNA; fluvastatin affects the expression of SGK1 protein CTD PMID:16696316 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Sgk2 serum/glucocorticoid regulated kinase 2 multiple interactions ISO [fluvastatin co-treated with NR1I2 protein] results in increased expression of SGK2 mRNA CTD PMID:24204015 NCBI chr 3:151,644,102...151,669,480
Ensembl chr 3:151,644,102...151,669,480
JBrowse link
G Slc15a1 solute carrier family 15 member 1 decreases activity ISO fluvastatin results in decreased activity of SLC15A1 protein CTD PMID:15846457 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 affects import ISO SLCO1B3 protein affects the import of fluvastatin CTD PMID:16046661 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 affects import ISO SLCO2B1 protein affects the import of fluvastatin CTD PMID:16046661 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO [fluvastatin co-treated with Doxorubicin] results in increased expression of SOD2 protein
fluvastatin results in increased expression of SOD2 mRNA; fluvastatin results in increased expression of SOD2 protein
[fluvastatin results in decreased expression of DDB2] which results in increased expression of SOD2 mRNA; Mevalonic Acid inhibits the reaction [fluvastatin results in increased expression of SOD2 protein]
CTD PMID:19147586 PMID:24964743 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of SOS2 mRNA CTD PMID:16996129 NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692
JBrowse link
G Spin2a spindlin family, member 2A multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of SPIN2A mRNA CTD PMID:16996129 NCBI chr  X:17,511,018...17,513,001
Ensembl chr  X:17,511,022...17,513,001
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of SPP1 mRNA] CTD PMID:16452496 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Tfpi tissue factor pathway inhibitor increases expression ISO fluvastatin results in increased expression of TFPI protein CTD PMID:16142594 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880
JBrowse link
G Tfrc transferrin receptor multiple interactions
decreases expression
ISO [[fluvastatin results in increased expression of NOS2] which results in increased abundance of Nitric Oxide] which results in decreased expression of TFRC; [fluvastatin results in decreased expression of TFRC protein] which results in decreased uptake of Iron; Amitrole inhibits the reaction [fluvastatin results in decreased expression of TFRC protein]; Mevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of TFRC mRNA]; Mevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of TFRC protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [fluvastatin results in decreased expression of TFRC protein]
fluvastatin results in decreased expression of TFRC mRNA; fluvastatin results in decreased expression of TFRC protein
CTD PMID:24964743 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgfb1 transforming growth factor, beta 1 affects expression EXP fluvastatin affects the expression of TGFB1 protein CTD PMID:16696316 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of TNFRSF10A mRNA CTD PMID:16996129 NCBI chr15:44,839,818...44,867,582 JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of TP53INP1 mRNA CTD PMID:16996129 NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
JBrowse link
G Vim vimentin multiple interactions EXP fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of VIM mRNA] CTD PMID:16452496 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Wnt11 Wnt family member 11 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of WNT11 mRNA CTD PMID:16996129 NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      chemical substance 13190
        mixture 12396
          racemate 10478
            fluvastatin 98
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        hydroxy carboxylic acid 3656
                                          hydroxy monocarboxylic acid 3656
                                            dihydroxy monocarboxylic acid 256
                                              (6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid 98
                                                (3R,5S)-fluvastatin 98
                                                  fluvastatin 98
paths to the root