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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:indolizidine alkaloid
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Accession:CHEBI:38511 term browser browse the term
Synonyms:related_synonym: indolizidine alkaloids;   indolizine alkaloids
 xref: Patent:WO9106547



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lycorine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd3 cyclin D3 decreases expression ISO lycorine results in decreased expression of CCND3 mRNA CTD PMID:23376478 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Cdh5 cadherin 5 decreases expression ISO lycorine results in decreased expression of CDH5 mRNA CTD PMID:23376478 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO lycorine results in increased expression of CDKN1A mRNA CTD PMID:23376478 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Il6 interleukin 6 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:22155741 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein] CTD PMID:22155741 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; lycorine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22155741 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:22155741 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Sema4d semaphorin 4D decreases expression ISO lycorine results in decreased expression of SEMA4D mRNA CTD PMID:23376478 NCBI chr17:13,430,324...13,537,146
Ensembl chr17:13,430,379...13,537,138
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] CTD PMID:22155741 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein] CTD PMID:22155741 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:22155741 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO lycorine results in decreased expression of VEGFA mRNA CTD PMID:23376478 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
swainsonine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression EXP Swainsonine results in increased expression of AIFM1 protein CTD PMID:33186601 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
EXP [Swainsonine co-treated with bafilomycin A1] results in increased expression of BECN1 protein
Swainsonine results in increased expression of BECN1 protein
CTD PMID:33186601 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
EXP [Swainsonine co-treated with aloxistatin] results in increased cleavage of CASP3 protein; [Swainsonine co-treated with bafilomycin A1] results in increased cleavage of CASP3 protein
Swainsonine results in increased cleavage of CASP3 protein
CTD PMID:33186601 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage EXP Swainsonine results in increased cleavage of CASP8 protein CTD PMID:33186601 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
EXP Swainsonine results in increased cleavage of CASP9 protein
[Swainsonine co-treated with Sirolimus] results in increased cleavage of CASP9 protein
CTD PMID:33186601 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ctsd cathepsin D decreases expression EXP Swainsonine results in decreased expression of CTSD protein CTD PMID:33186601 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Faslg Fas ligand increases expression EXP Swainsonine results in increased expression of FASLG protein CTD PMID:33186601 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Tfeb transcription factor EB decreases expression EXP Swainsonine results in decreased expression of TFEB protein CTD PMID:33186601 NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        biochemical role 19630
          metabolite 19611
            alkaloid 5706
              indolizidine alkaloid 20
                (1R,8aS)-octahydroindolizin-1-ol(1+) 0
                (8aS)-octahydroindolizin-1-one(1+) 0
                caranine + 0
                castanospermine 0
                erythrinan 0
                galanthan + 12
                lycorine 12
                slaframine 0
                swainsonine 8
                tashiromine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic molecule 19819
                              organic cyclic compound 19581
                                organic heterocyclic compound 18804
                                  organic heteropolycyclic compound 18274
                                    organic heterobicyclic compound 17165
                                      indolizines 64
                                        indolizidine alkaloid 20
                                          (1R,8aS)-octahydroindolizin-1-ol(1+) 0
                                          (8aS)-octahydroindolizin-1-one(1+) 0
                                          caranine + 0
                                          castanospermine 0
                                          erythrinan 0
                                          galanthan + 12
                                          lycorine 12
                                          slaframine 0
                                          swainsonine 8
                                          tashiromine + 0
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