CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: indolizidine alkaloid
Accession: CHEBI:38511
browse the term
Synonyms: related_synonym: indolizidine alkaloids; indolizine alkaloids
xref: Patent:WO9106547
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Ccnd3
cyclin D3
decreases expression
ISO
lycorine results in decreased expression of CCND3 mRNA
CTD
PMID:23376478
NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
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Cdh5
cadherin 5
decreases expression
ISO
lycorine results in decreased expression of CDH5 mRNA
CTD
PMID:23376478
NCBI chr19:1,025,122...1,074,333
Ensembl chr19:1,023,683...1,074,365
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
lycorine results in increased expression of CDKN1A mRNA
CTD
PMID:23376478
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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Il6
interleukin 6
multiple interactions
ISO
lycorine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
CTD
PMID:22155741
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Mapk14
mitogen activated protein kinase 14
multiple interactions
ISO
lycorine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein]
CTD
PMID:22155741
NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
lycorine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; lycorine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD
PMID:22155741
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
lycorine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD
PMID:22155741
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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Sema4d
semaphorin 4D
decreases expression
ISO
lycorine results in decreased expression of SEMA4D mRNA
CTD
PMID:23376478
NCBI chr17:13,516,276...13,538,513
Ensembl chr17:13,488,376...13,553,974
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Stat1
signal transducer and activator of transcription 1
multiple interactions
ISO
lycorine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]
CTD
PMID:22155741
NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
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Stat3
signal transducer and activator of transcription 3
multiple interactions
ISO
lycorine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]
CTD
PMID:22155741
NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
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Tnf
tumor necrosis factor
multiple interactions
ISO
lycorine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD
PMID:22155741
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Vegfa
vascular endothelial growth factor A
decreases expression
ISO
lycorine results in decreased expression of VEGFA mRNA
CTD
PMID:23376478
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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