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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3,5-dimethyl-4-(methylsulfanyl)phenol
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Accession:CHEBI:38509 term browser browse the term
Definition:An aryl sulfide that has formula C9H12OS.
Synonyms:related_synonym: 3,5-Dimethyl-4-(methylthio)phenol;   4-(Methylthio)-3,5-dimethylphenol;   4-Methylthio-3,5-xylenol;   Formula=C9H12OS;   InChI=1S/C9H12OS/c1-6-4-8(10)5-7(2)9(6)11-3/h4-5,10H,1-3H3;   InChIKey=JGFZITGNFAVSKU-UHFFFAOYSA-N;   SMILES=CSc1c(C)cc(O)cc1C
 xref: CAS:7379-51-3


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methiocarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP Methiocarb results in decreased activity of ACHE protein CTD PMID:19934164 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Alb albumin increases hydrolysis
multiple interactions
ISO
EXP
ALB protein results in increased hydrolysis of Methiocarb
bis(4-nitrophenyl)phosphate inhibits the reaction [ALB protein results in increased hydrolysis of Methiocarb]
CTD PMID:27665777 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ar androgen receptor multiple interactions ISO
EXP
Dihydrotestosterone inhibits the reaction [Methiocarb results in increased activity of AR protein]; Methiocarb inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Methiocarb inhibits the reaction [Metribolone results in increased activity of AR protein]
Methiocarb inhibits the reaction [Metribolone results in increased expression of AR mRNA]
CTD PMID:15064155, PMID:15519604, PMID:18324785, PMID:21310686 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP [Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein CTD PMID:22649187 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases metabolic processing
ISO [CYP2B6 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide CTD PMID:27665777 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing
multiple interactions
ISO CYP2C19 protein results in increased metabolism of Methiocarb
[CYP2C19 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide
CTD PMID:27665777 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
multiple interactions
ISO CYP2D6 protein results in increased metabolism of Methiocarb
[CYP2D6 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide
CTD PMID:27665777 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Esr1 estrogen receptor 1 increases activity
increases expression
ISO Methiocarb results in increased activity of ESR1 protein
Methiocarb results in increased expression of ESR1 protein
CTD PMID:15064155, PMID:19206145 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases activity
increases expression
ISO Methiocarb results in increased activity of ESR2 protein
Methiocarb results in increased expression of ESR2 mRNA
CTD PMID:15064155, PMID:15130599 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 multiple interactions
increases metabolic processing
ISO [FMO1 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide CTD PMID:27665777 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Methiocarb results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Methiocarb results in decreased expression of LHB protein CTD PMID:15519604 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity EXP Methiocarb results in increased activity of NR1I2 protein CTD PMID:27665777 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Odc1 ornithine decarboxylase 1 decreases expression EXP Methiocarb results in decreased expression of ODC1 mRNA CTD PMID:15519604 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity EXP Methiocarb results in increased activity of PPARA protein CTD PMID:27665777 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Methiocarb binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Scgb2a2 secretoglobin, family 2A, member 2 decreases expression EXP Methiocarb results in decreased expression of SCGB2A2 mRNA CTD PMID:15519604 NCBI chr 1:225,825,419...225,830,374
Ensembl chr 1:225,825,356...225,830,355
Ensembl chr 1:225,825,356...225,830,355
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      molecular entity 19784
        polyatomic entity 19697
          heteroatomic molecular entity 19622
            hydroxides 19068
              organic hydroxy compound 18634
                phenols 18112
                  3,5-dimethyl-4-(methylsulfanyl)phenol 17
                    methiocarb 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            heteroorganic entity 19148
                              organochalcogen compound 18856
                                organosulfur compound 15190
                                  organic sulfide 8133
                                    aryl sulfide 7473
                                      3,5-dimethyl-4-(methylsulfanyl)phenol 17
                                        methiocarb 17
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.