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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methiocarb
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Accession:CHEBI:38508 term browser browse the term
Definition:A carbamate ester obtained by the formal condensation of the phenolic group of 3,5-dimethyl-4-(methylsulfanyl)phenol with the carboxy group of methylcarbamic acid.
Synonyms:exact_synonym: 3,5-dimethyl-4-(methylsulfanyl)phenyl methylcarbamate
 related_synonym: 3,5-Dimethyl-4-(methylthio)phenol methylcarbamate;   3,5-Dimethyl-4-(methylthio)phenyl methylcarbamate;   3,5-Dimethyl-4-methylthiophenyl N-methylcarbamate;   4-Methylmercapto-3,5-dimethylphenyl N-methylcarbamate;   4-Methylmercapto-3,5-xylyl methylcarbamate;   4-Methylthio-3,5-dimethylphenyl methylcarbamate;   4-Methylthio-3,5-xylyl methylcarbamate;   Formula=C11H15NO2S;   InChI=1S/C11H15NO2S/c1-7-5-9(14-11(13)12-3)6-8(2)10(7)15-4/h5-6H,1-4H3,(H,12,13);   InChIKey=YFBPRJGDJKVWAH-UHFFFAOYSA-N;   SMILES=CNC(=O)Oc1cc(C)c(SC)c(C)c1;   mesurol
 xref: Beilstein:1881431;   CAS:2032-65-7;   KEGG:C18651
 xref_mesh: MESH:D008714
 xref: PMID:19270930;   PMID:22623520;   PMID:24380738;   PMID:9197969;   PPDB:457;   Pesticides:methiocarb;   Reaxys:1881431;   Wikipedia:Methiocarb



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methiocarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP Methiocarb results in decreased activity of ACHE protein CTD PMID:19934164 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Alb albumin increases hydrolysis
multiple interactions
ISO
EXP
ALB protein results in increased hydrolysis of Methiocarb
bis(4-nitrophenyl)phosphate inhibits the reaction [ALB protein results in increased hydrolysis of Methiocarb]
CTD PMID:27665777 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Ar androgen receptor multiple interactions ISO
EXP
Dihydrotestosterone inhibits the reaction [Methiocarb results in increased activity of AR protein]; Methiocarb inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Methiocarb inhibits the reaction [Metribolone results in increased activity of AR protein]
Methiocarb inhibits the reaction [Metribolone results in increased expression of AR mRNA]
CTD PMID:15064155 PMID:15519604 PMID:18324785 PMID:21310686 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP [Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein CTD PMID:22649187 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases metabolic processing
ISO [CYP2B6 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide CTD PMID:27665777 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing
multiple interactions
ISO CYP2C19 protein results in increased metabolism of Methiocarb
[CYP2C19 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide
CTD PMID:27665777 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
multiple interactions
ISO CYP2D6 protein results in increased metabolism of Methiocarb
[CYP2D6 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide
CTD PMID:27665777 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Esr1 estrogen receptor 1 increases activity
increases expression
ISO Methiocarb results in increased activity of ESR1 protein
Methiocarb results in increased expression of ESR1 protein
CTD PMID:15064155 PMID:19206145 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 increases activity
increases expression
ISO Methiocarb results in increased activity of ESR2 protein
Methiocarb results in increased expression of ESR2 mRNA
CTD PMID:15064155 PMID:15130599 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 multiple interactions
increases metabolic processing
ISO [FMO1 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide CTD PMID:27665777 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Methiocarb results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Methiocarb results in decreased expression of LHB protein CTD PMID:15519604 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity EXP Methiocarb results in increased activity of NR1I2 protein CTD PMID:27665777 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Odc1 ornithine decarboxylase 1 decreases expression EXP Methiocarb results in decreased expression of ODC1 mRNA CTD PMID:15519604 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity EXP Methiocarb results in increased activity of PPARA protein CTD PMID:27665777 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Methiocarb binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Scgb2a1 secretoglobin, family 2A, member 1 decreases expression EXP Methiocarb results in decreased expression of SCGB2A2 mRNA CTD PMID:15519604 NCBI chr 1:206,497,848...206,501,211
Ensembl chr 1:206,497,849...206,501,211
Ensembl chr 1:206,497,849...206,501,211
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      application 19492
        agrochemical 15185
          methiocarb 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic group 18713
                              organic divalent group 18697
                                organodiyl group 18697
                                  carbonyl group 18646
                                    carbonyl compound 18646
                                      carboxylic acid 18341
                                        amino acid 14869
                                          methylcarbamic acid 83
                                            methiocarb 17
paths to the root