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G |
CYP2A6 |
cytochrome P450 family 2 subfamily A member 6 |
increases expression |
EXP |
chlorfluazuron results in increased expression of CYP2A6 mRNA |
CTD |
PMID:22310298 |
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NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
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G |
CYP2B6 |
cytochrome P450 family 2 subfamily B member 6 |
increases expression increases activity |
EXP |
chlorfluazuron results in increased expression of CYP2B6 mRNA chlorfluazuron results in increased activity of CYP2B6 protein |
CTD |
PMID:22310298 |
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NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
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G |
CYP2E1 |
cytochrome P450 family 2 subfamily E member 1 |
multiple interactions decreases activity |
EXP |
chlorfluazuron inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone] chlorfluazuron results in decreased activity of CYP2E1 protein |
CTD |
PMID:22634058 |
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NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
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G |
CYP3A4 |
cytochrome P450 family 3 subfamily A member 4 |
increases expression |
EXP |
chlorfluazuron results in increased expression of CYP3A4 mRNA |
CTD |
PMID:22310298 |
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NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
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G |
CYP1A1 |
cytochrome P450 family 1 subfamily A member 1 |
increases expression |
ISO |
Diflubenzuron results in increased expression of CYP1A1 protein |
CTD |
PMID:8812189 |
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NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
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G |
CYP1A2 |
cytochrome P450 family 1 subfamily A member 2 |
affects binding |
EXP |
Diflubenzuron binds to CYP1A2 protein |
CTD |
PMID:32278787 |
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NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
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G |
CYP3A4 |
cytochrome P450 family 3 subfamily A member 4 |
affects binding |
EXP |
Diflubenzuron binds to CYP3A4 protein |
CTD |
PMID:32278787 |
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NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
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G |
NR1I2 |
nuclear receptor subfamily 1 group I member 2 |
increases activity |
EXP |
Diflubenzuron results in increased activity of NR1I2 protein |
CTD |
PMID:16565514 |
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NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487
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G |
AKT1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [flufenoxuron results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:33771252 |
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NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
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AR |
androgen receptor |
decreases expression |
ISO |
flufenoxuron results in decreased expression of AR mRNA |
CTD |
PMID:33771252 |
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NCBI chr X:67,544,021...67,730,619
Ensembl chr X:67,544,021...67,730,619
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G |
BAD |
BCL2 associated agonist of cell death |
decreases phosphorylation |
ISO |
flufenoxuron results in decreased phosphorylation of BAD protein |
CTD |
PMID:33771252 |
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NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704
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G |
BAK1 |
BCL2 antagonist/killer 1 |
increases expression |
ISO |
flufenoxuron results in increased expression of BAK1 protein |
CTD |
PMID:33771252 |
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NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293
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G |
BCL2L1 |
BCL2 like 1 |
decreases expression |
ISO |
flufenoxuron results in decreased expression of BCL2L1 protein |
CTD |
PMID:33771252 |
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NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
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CYP17A1 |
cytochrome P450 family 17 subfamily A member 1 |
increases expression |
ISO |
flufenoxuron results in increased expression of CYP17A1 mRNA |
CTD |
PMID:33771252 |
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NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472
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CYP19A1 |
cytochrome P450 family 19 subfamily A member 1 |
increases expression |
ISO |
flufenoxuron results in increased expression of CYP19A1 mRNA |
CTD |
PMID:33771252 |
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NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601
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G |
DDIT3 |
DNA damage inducible transcript 3 |
increases expression |
ISO |
flufenoxuron results in increased expression of DDIT3 protein |
CTD |
PMID:33771252 |
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NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
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G |
EIF2S1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases phosphorylation |
ISO |
flufenoxuron results in increased phosphorylation of EIF2S1 protein |
CTD |
PMID:33771252 |
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NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516
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G |
ERN1 |
endoplasmic reticulum to nucleus signaling 1 |
increases expression |
ISO |
flufenoxuron results in increased expression of ERN1 protein |
CTD |
PMID:33771252 |
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NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819
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G |
HSD17B1 |
hydroxysteroid 17-beta dehydrogenase 1 |
decreases expression |
ISO |
flufenoxuron results in decreased expression of HSD17B1 mRNA |
CTD |
PMID:33771252 |
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NCBI chr17:42,552,923...42,555,214
Ensembl chr17:42,552,922...42,555,214
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G |
HSD17B3 |
hydroxysteroid 17-beta dehydrogenase 3 |
increases expression |
ISO |
flufenoxuron results in increased expression of HSD17B3 mRNA |
CTD |
PMID:33771252 |
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NCBI chr 9:96,235,306...96,302,176
Ensembl chr 9:96,235,306...96,302,176
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G |
HSPA9 |
heat shock protein family A (Hsp70) member 9 |
increases expression |
ISO |
flufenoxuron results in increased expression of HSPA9 protein |
CTD |
PMID:33771252 |
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NCBI chr 5:138,553,756...138,575,401
Ensembl chr 5:138,553,756...138,575,675
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G |
JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
ISO |
flufenoxuron results in decreased expression of JUN mRNA |
CTD |
PMID:33771252 |
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NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
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G |
JUND |
JunD proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
ISO |
flufenoxuron results in decreased expression of JUND mRNA |
CTD |
PMID:33771252 |
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NCBI chr19:18,279,694...18,281,622
Ensembl chr19:18,279,694...18,281,622
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G |
MAPK1 |
mitogen-activated protein kinase 1 |
increases phosphorylation multiple interactions |
ISO |
flufenoxuron results in increased phosphorylation of MAPK1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:33771252 |
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NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
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G |
MAPK3 |
mitogen-activated protein kinase 3 |
increases phosphorylation multiple interactions |
ISO |
flufenoxuron results in increased phosphorylation of MAPK3 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:33771252 |
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NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
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G |
MAPK8 |
mitogen-activated protein kinase 8 |
increases phosphorylation multiple interactions |
ISO |
flufenoxuron results in increased phosphorylation of MAPK8 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK8 protein]; U 0126 inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:33771252 |
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NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
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G |
PCNA |
proliferating cell nuclear antigen |
decreases expression |
ISO |
flufenoxuron results in decreased expression of PCNA protein |
CTD |
PMID:33771252 |
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NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
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G |
RMDN3 |
regulator of microtubule dynamics 3 |
increases expression |
ISO |
flufenoxuron results in increased expression of RMDN3 protein |
CTD |
PMID:33771252 |
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NCBI chr15:40,735,887...40,755,254
Ensembl chr15:40,735,884...40,755,851
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G |
RPS6KA1 |
ribosomal protein S6 kinase A1 |
multiple interactions decreases phosphorylation |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [flufenoxuron results in decreased phosphorylation of RPS6KA1 protein]; U 0126 inhibits the reaction [flufenoxuron results in decreased phosphorylation of RPS6KA1 protein] |
CTD |
PMID:33771252 |
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NCBI chr 1:26,529,761...26,575,025
Ensembl chr 1:26,529,761...26,575,030
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G |
RPS6KB1 |
ribosomal protein S6 kinase B1 |
decreases phosphorylation multiple interactions |
ISO |
flufenoxuron results in decreased phosphorylation of RPS6KB1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [flufenoxuron results in decreased phosphorylation of RPS6KB1 protein]; pyrazolanthrone affects the reaction [flufenoxuron results in decreased phosphorylation of RPS6KB1 protein]; U 0126 inhibits the reaction [flufenoxuron results in decreased phosphorylation of RPS6KB1 protein] |
CTD |
PMID:33771252 |
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NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574
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G |
SQSTM1 |
sequestosome 1 |
increases phosphorylation |
ISO |
flufenoxuron results in increased phosphorylation of SQSTM1 protein |
CTD |
PMID:33771252 |
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NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
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G |
STAR |
steroidogenic acute regulatory protein |
increases expression |
ISO |
flufenoxuron results in increased expression of STAR mRNA |
CTD |
PMID:33771252 |
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NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992
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VAPB |
VAMP associated protein B and C |
increases expression |
ISO |
flufenoxuron results in increased expression of VAPB protein |
CTD |
PMID:33771252 |
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NCBI chr20:58,389,229...58,451,101
Ensembl chr20:58,389,229...58,451,101
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G |
VDAC1 |
voltage dependent anion channel 1 |
increases expression |
ISO |
flufenoxuron results in increased expression of VDAC1 protein |
CTD |
PMID:33771252 |
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NCBI chr 5:133,971,871...134,114,540
Ensembl chr 5:133,971,871...134,004,975
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ALB |
albumin |
decreases expression |
ISO |
hexafluoron results in decreased expression of ALB protein |
CTD |
PMID:34993831 |
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NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
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G |
BAX |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
hexafluoron results in increased expression of BAX mRNA |
CTD |
PMID:35773501 |
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NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
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G |
BCL2 |
BCL2 apoptosis regulator |
decreases expression |
ISO |
hexafluoron results in decreased expression of BCL2 mRNA |
CTD |
PMID:35773501 |
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NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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G |
CASP3 |
caspase 3 |
increases expression |
ISO |
hexafluoron results in increased expression of CASP3 mRNA; hexafluoron results in increased expression of CASP3 protein |
CTD |
PMID:34993831 PMID:35773501 |
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NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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CAT |
catalase |
decreases activity |
ISO |
hexafluoron results in decreased activity of CAT protein |
CTD |
PMID:35773501 |
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NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
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G |
CYP2A6 |
cytochrome P450 family 2 subfamily A member 6 |
increases expression |
EXP |
hexafluoron results in increased expression of CYP2A6 mRNA |
CTD |
PMID:22310298 |
|
NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
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G |
CYP2B6 |
cytochrome P450 family 2 subfamily B member 6 |
increases activity increases expression |
EXP |
hexafluoron results in increased activity of CYP2B6 protein hexafluoron results in increased expression of CYP2B6 mRNA |
CTD |
PMID:22310298 |
|
NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
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G |
CYP3A4 |
cytochrome P450 family 3 subfamily A member 4 |
increases expression |
EXP |
hexafluoron results in increased expression of CYP3A4 mRNA |
CTD |
PMID:22310298 |
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NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
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G |
GPT |
glutamic--pyruvic transaminase |
increases expression |
ISO |
hexafluoron results in increased expression of GPT protein |
CTD |
PMID:34993831 |
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NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
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G |
HMOX1 |
heme oxygenase 1 |
increases expression |
ISO |
hexafluoron results in increased expression of HMOX1 mRNA |
CTD |
PMID:34993831 |
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NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
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G |
KEAP1 |
kelch like ECH associated protein 1 |
decreases expression |
ISO |
hexafluoron results in decreased expression of KEAP1 mRNA |
CTD |
PMID:34993831 |
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NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
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G |
MAPK8 |
mitogen-activated protein kinase 8 |
increases expression |
ISO |
hexafluoron results in increased expression of MAPK8 mRNA |
CTD |
PMID:34993831 PMID:35773501 |
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NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
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G |
TNF |
tumor necrosis factor |
increases expression |
ISO |
hexafluoron results in increased expression of TNF protein |
CTD |
PMID:34993831 |
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NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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G |
CAT |
catalase |
increases activity |
EXP |
triflumuron results in increased activity of CAT protein |
CTD |
PMID:32312157 |
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NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
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G |
CYP1A1 |
cytochrome P450 family 1 subfamily A member 1 |
increases metabolic processing |
EXP |
CYP1A1 protein results in increased metabolism of triflumuron |
CTD |
PMID:31082524 |
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NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
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G |
CYP1A2 |
cytochrome P450 family 1 subfamily A member 2 |
multiple interactions increases metabolic processing |
EXP |
furafylline inhibits the reaction [CYP1A2 protein results in increased metabolism of triflumuron] |
CTD |
PMID:31082524 |
|
NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
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G |
CYP2A6 |
cytochrome P450 family 2 subfamily A member 6 |
increases metabolic processing |
EXP |
CYP2A6 protein results in increased metabolism of triflumuron |
CTD |
PMID:31082524 |
|
NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
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G |
CYP2B6 |
cytochrome P450 family 2 subfamily B member 6 |
increases metabolic processing |
EXP |
CYP2B6 protein results in increased metabolism of triflumuron |
CTD |
PMID:31082524 |
|
NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
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G |
CYP2C18 |
cytochrome P450 family 2 subfamily C member 18 |
increases metabolic processing |
EXP |
CYP2C18 protein results in increased metabolism of triflumuron |
CTD |
PMID:31082524 |
|
NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190
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G |
CYP2C19 |
cytochrome P450 family 2 subfamily C member 19 |
multiple interactions increases metabolic processing |
EXP |
Sulfaphenazole inhibits the reaction [CYP2C19 protein results in increased metabolism of triflumuron] |
CTD |
PMID:31082524 |
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NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
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G |
CYP2C8 |
cytochrome P450 family 2 subfamily C member 8 |
increases metabolic processing |
EXP |
CYP2C8 protein results in increased metabolism of triflumuron |
CTD |
PMID:31082524 |
|
NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
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G |
CYP2C9 |
cytochrome P450 family 2 subfamily C member 9 |
increases metabolic processing |
EXP |
CYP2C9 protein results in increased metabolism of triflumuron |
CTD |
PMID:31082524 |
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NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
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G |
CYP2D6 |
cytochrome P450 family 2 subfamily D member 6 |
increases metabolic processing |
EXP |
CYP2D6 protein results in increased metabolism of triflumuron |
CTD |
PMID:31082524 |
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NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865
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G |
CYP3A4 |
cytochrome P450 family 3 subfamily A member 4 |
increases metabolic processing multiple interactions |
EXP |
CYP3A4 protein results in increased metabolism of triflumuron Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of triflumuron] |
CTD |
PMID:31082524 |
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NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
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