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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carbosulfan
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Accession:CHEBI:38476 term browser browse the term
Definition:A 1-benzofuran that has formula C20H32N2O3S.
Synonyms:exact_synonym: 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl [(dibutylamino)sulfanyl](methyl)carbamate
 related_synonym: Dibutylaminosulfenylcarbofuran;   Formula=C20H32N2O3S;   InChI=1S/C20H32N2O3S/c1-6-8-13-22(14-9-7-2)26-21(5)19(23)24-17-12-10-11-16-15-20(3,4)25-18(16)17/h10-12H,6-9,13-15H2,1-5H3;   InChIKey=JLQUFIHWVLZVTJ-UHFFFAOYSA-N;   SMILES=CCCCN(CCCC)SN(C)C(=O)Oc1cccc2CC(C)(C)Oc12
 xref: Beilstein:1397995;   CAS:55285-14-8;   KEGG:C18416
 xref_mesh: MESH:C035038
 xref: PPDB:121



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carbosulfan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP
ISO
carbosulfan results in decreased activity of ACHE protein
carbosulfan metabolite results in decreased activity of ACHE protein; carbosulfan results in decreased activity of ACHE protein
CTD PMID:3710030 PMID:33844597 NCBI chr12:25,042,882...25,050,608 JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
increases expression
increases metabolic processing
ISO carbosulfan results in increased activity of CYP2B6 protein
carbosulfan results in increased expression of CYP2B6 mRNA
CYP2B6 protein results in increased metabolism of carbosulfan
CTD PMID:20307514 PMID:22310298 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
increases activity
decreases activity
ISO CYP3A4 protein results in increased metabolism of and results in increased activity of carbosulfan; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of carbosulfan]
carbosulfan results in increased expression of CYP3A4 mRNA
carbosulfan results in increased activity of CYP3A4 protein
carbosulfan results in decreased activity of CYP3A4 protein
CTD PMID:20307514 PMID:22310298 NCBI chr12:14,321,771...14,343,886 JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO CYP3A5 protein results in increased metabolism of carbosulfan CTD PMID:20307514 NCBI chr12:21,919,955...21,960,160 JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression ISO carbosulfan results in increased expression of NR1I3 mRNA CTD PMID:22310298 NCBI chr13:86,165,327...86,170,362 JBrowse link

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  CHEBI ontology 19898
    role 19869
      application 19715
        agrochemical 16889
          carbosulfan 5
Path 2
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  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19535
                              organochalcogen compound 19296
                                organooxygen compound 19213
                                  carbon oxoacid 18682
                                    carbamic acid 17594
                                      carbamate ester 7521
                                        carbosulfan 5
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