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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carbosulfan
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Accession:CHEBI:38476 term browser browse the term
Definition:A 1-benzofuran that has formula C20H32N2O3S.
Synonyms:exact_synonym: 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl [(dibutylamino)sulfanyl](methyl)carbamate
 related_synonym: Dibutylaminosulfenylcarbofuran;   Formula=C20H32N2O3S;   InChI=1S/C20H32N2O3S/c1-6-8-13-22(14-9-7-2)26-21(5)19(23)24-17-12-10-11-16-15-20(3,4)25-18(16)17/h10-12H,6-9,13-15H2,1-5H3;   InChIKey=JLQUFIHWVLZVTJ-UHFFFAOYSA-N;   SMILES=CCCCN(CCCC)SN(C)C(=O)Oc1cccc2CC(C)(C)Oc12
 xref: Beilstein:1397995;   CAS:55285-14-8;   KEGG:C18416
 xref_mesh: MESH:C035038
 xref: PPDB:121


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carbosulfan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP carbosulfan results in decreased activity of ACHE protein CTD PMID:3710030 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
increases expression
increases metabolic processing
ISO carbosulfan results in increased activity of CYP2B6 protein
carbosulfan results in increased expression of CYP2B6 mRNA
CYP2B6 protein results in increased metabolism of carbosulfan
CTD PMID:20307514 PMID:22310298 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity
increases activity
increases expression
ISO CYP3A4 protein results in increased metabolism of and results in increased activity of carbosulfan; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of carbosulfan]
carbosulfan results in decreased activity of CYP3A4 protein
carbosulfan results in increased activity of CYP3A4 protein
carbosulfan results in increased expression of CYP3A4 mRNA
CTD PMID:20307514 PMID:22310298 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO CYP3A5 protein results in increased metabolism of carbosulfan CTD PMID:20307514 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression ISO carbosulfan results in increased expression of NR1I3 mRNA CTD PMID:22310298 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 19821
    role 19769
      application 19481
        agrochemical 15037
          carbosulfan 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic ester 15884
                                        carbamate ester 7445
                                          carbosulfan 5
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