|
G |
Ache |
acetylcholinesterase |
decreases activity |
EXP ISO |
carbosulfan results in decreased activity of ACHE protein carbosulfan metabolite results in decreased activity of ACHE protein; carbosulfan results in decreased activity of ACHE protein |
CTD |
PMID:3710030 PMID:33844597 |
|
NCBI chr12:25,042,882...25,050,608
|
|
G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
increases activity increases expression increases metabolic processing |
ISO |
carbosulfan results in increased activity of CYP2B6 protein carbosulfan results in increased expression of CYP2B6 mRNA CYP2B6 protein results in increased metabolism of carbosulfan |
CTD |
PMID:20307514 PMID:22310298 |
|
NCBI chr 1:90,780,468...90,859,852
|
|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions increases expression increases activity decreases activity |
ISO |
CYP3A4 protein results in increased metabolism of and results in increased activity of carbosulfan; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of carbosulfan] carbosulfan results in increased expression of CYP3A4 mRNA carbosulfan results in increased activity of CYP3A4 protein carbosulfan results in decreased activity of CYP3A4 protein |
CTD |
PMID:20307514 PMID:22310298 |
|
NCBI chr12:14,321,771...14,343,886
|
|
G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
increases metabolic processing |
ISO |
CYP3A5 protein results in increased metabolism of carbosulfan |
CTD |
PMID:20307514 |
|
NCBI chr12:21,919,955...21,960,160
|
|
G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
increases expression |
ISO |
carbosulfan results in increased expression of NR1I3 mRNA |
CTD |
PMID:22310298 |
|
NCBI chr13:86,165,327...86,170,362
|
|