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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:acetonitrile
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Accession:CHEBI:38472 term browser browse the term
Definition:A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group.
Synonyms:related_synonym: CH3-C#N;   Formula=C2H3N;   InChI=1S/C2H3N/c1-2-3/h1H3;   InChIKey=WEVYAHXRMPXWCK-UHFFFAOYSA-N;   MeCN;   NCMe;   SMILES=CC#N;   cyanomethane;   ethanenitrile;   methyl cyanide
 alt_id: CHEBI:22185;   CHEBI:30972;   CHEBI:41432
 xref: Beilstein:741857;   CAS:75-05-8;   Gmelin:895
 xref_mesh: MESH:C032159
 xref: PDBeChem:CCN;   PMID:17347819;   PMID:19100763;   PMID:20370615;   PMID:985423;   PPDB:1349;   Reaxys:741857;   Wikipedia:Acetonitrile


show annotations for term's descendants           Sort by:
acetonitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 multiple interactions EXP acetonitrile inhibits the reaction [CYP2A2 protein results in increased metabolism of 7-benzyloxyquinoline] CTD PMID:19858067 NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP acetonitrile inhibits the reaction [CYP2B1 protein results in increased metabolism of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19858067 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP
ISO		 acetonitrile inhibits the reaction [CYP2C11 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]
acetonitrile promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]		 CTD PMID:10611138 PMID:19858067 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 multiple interactions EXP acetonitrile inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin] CTD PMID:19858067 NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO
EXP		 acetonitrile inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]
acetonitrile inhibits the reaction [CYP2E1 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]		 CTD PMID:9143349 PMID:19858067 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP acetonitrile inhibits the reaction [CYP3A23-3A1 protein results in increased metabolism of 7-benzyloxyquinoline] CTD PMID:19858067 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Nefh neurofilament heavy chain affects expression EXP acetonitrile affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nherf1 NHERF family PDZ scaffold protein 1 increases expression ISO acetonitrile results in increased expression of NHERF1 protein CTD PMID:22434383 NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions
decreases activity		 ISO acetonitrile inhibits the reaction [SULT1A1 protein results in increased sulfation of 1-hydroxypyrene]; acetonitrile inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]
acetonitrile results in decreased activity of SULT1A1 protein		 CTD PMID:14570759 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions ISO acetonitrile promotes the reaction [SULT1E1 protein results in increased sulfation of 1-hydroxypyrene] CTD PMID:14570759 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
phoxim term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP
ISO		 phoxim metabolite results in decreased activity of ACHE protein; phoxim results in decreased activity of ACHE protein CTD PMID:15793557 PMID:33497710 PMID:33844597 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Ar androgen receptor multiple interactions ISO phoxim inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arl6ip5 ADP-ribosylation factor like GTPase 6 interacting protein 5 affects expression ISO phoxim affects the expression of ARL6IP5 protein CTD PMID:15799245 NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608 		JBrowse link
G Bche butyrylcholinesterase decreases activity EXP phoxim metabolite results in decreased activity of BCHE protein CTD PMID:33497710 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Cldn4 claudin 4 decreases expression
multiple interactions		 EXP phoxim results in decreased expression of CLDN4 mRNA
Vitamin E inhibits the reaction [phoxim results in decreased expression of CLDN4 mRNA]		 CTD PMID:30003487 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP phoxim results in increased expression of CYP2B1 mRNA CTD PMID:36356836 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO phoxim binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression
multiple interactions		 EXP phoxim results in increased expression of GPX2 mRNA
Vitamin E inhibits the reaction [phoxim results in increased expression of GPX2 mRNA]		 CTD PMID:30003487 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Il1b interleukin 1 beta decreases expression EXP phoxim results in decreased expression of IL1B mRNA CTD PMID:30003487 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions		 EXP phoxim results in decreased expression of IL6 mRNA
Vitamin E inhibits the reaction [phoxim results in decreased expression of IL6 mRNA]		 CTD PMID:30003487 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irs2 insulin receptor substrate 2 decreases expression EXP phoxim results in decreased expression of IRS2 mRNA CTD PMID:30090575 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression EXP phoxim results in increased expression of NFE2L2 mRNA CTD PMID:30003487 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO phoxim binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Ocln occludin multiple interactions
decreases expression		 EXP Vitamin E inhibits the reaction [phoxim results in decreased expression of OCLN mRNA] CTD PMID:30003487 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO phoxim binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO phoxim binds to and results in decreased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP Vitamin E inhibits the reaction [phoxim results in increased expression of TNF protein]
phoxim results in increased expression of TNF mRNA; phoxim results in increased expression of TNF protein		 CTD PMID:30003487 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO phoxim metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      application 19622
        solvent 16738
          polar solvent 15485
            polar aprotic solvent 604
              acetonitrile 27
                (2-methylphenyl)acetonitrile 0
                (hydroxyimino)(phenyl)acetonitrile + 18
                2-thienylacetonitrile 0
                3-phenylpropionitrile + 0
                4-chlorophenylacetonitrile 0
                [5-hydroxy-2-(4-hydroxyphenyl)-1-benzofuran-7-yl]acetonitrile 0
                acetonitrile oxide 0
                acetonitrile sulfide 0
                iminodiacetonitrile 0
                indole-3-acetonitrile + 0
                phenylacetonitrile + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            one-carbon compound 17849
                              hydrogen cyanide 4212
                                cyanides 4195
                                  nitrile 3976
                                    aliphatic nitrile 1696
                                      acetonitrile 27
                                        (2-methylphenyl)acetonitrile 0
                                        (hydroxyimino)(phenyl)acetonitrile + 18
                                        2-thienylacetonitrile 0
                                        3-phenylpropionitrile + 0
                                        4-chlorophenylacetonitrile 0
                                        [5-hydroxy-2-(4-hydroxyphenyl)-1-benzofuran-7-yl]acetonitrile 0
                                        acetonitrile oxide 0
                                        acetonitrile sulfide 0
                                        iminodiacetonitrile 0
                                        indole-3-acetonitrile + 0
                                        phenylacetonitrile + 0
paths to the root