|
G
|
Cyp2a2
|
cytochrome P450, family 2, subfamily a, polypeptide 2
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multiple interactions
|
EXP
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acetonitrile inhibits the reaction [CYP2A2 protein results in increased metabolism of 7-benzyloxyquinoline]
|
CTD |
PMID:19858067 |
|
NCBI chr 1:91,391,492...91,417,158
Ensembl chr 1:91,391,502...91,417,158
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G
|
Cyp2b1
|
cytochrome P450, family 2, subfamily b, polypeptide 1
|
multiple interactions
|
EXP
|
acetonitrile inhibits the reaction [CYP2B1 protein results in increased metabolism of 7-benzyloxy-4-trifluoromethylcoumarin]
|
CTD |
PMID:19858067 |
|
NCBI chr 1:90,646,098...90,669,762
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|
G
|
Cyp2c11
|
cytochrome P450, subfamily 2, polypeptide 11
|
multiple interactions
|
EXP
|
acetonitrile inhibits the reaction [CYP2C11 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]
|
CTD |
PMID:19858067 |
|
NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853
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|
G
|
Cyp2d2
|
cytochrome P450, family 2, subfamily d, polypeptide 2
|
multiple interactions
|
EXP
|
acetonitrile inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]
|
CTD |
PMID:19858067 |
|
NCBI chr 7:115,815,212...115,819,281
Ensembl chr 7:115,815,212...115,819,281
|
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G
|
Cyp2e1
|
cytochrome P450, family 2, subfamily e, polypeptide 1
|
multiple interactions
|
ISO EXP
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acetonitrile inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein] acetonitrile inhibits the reaction [CYP2E1 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]
|
CTD |
PMID:9143349 PMID:19858067 |
|
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495
|
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G
|
Cyp3a23-3a1
|
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
|
multiple interactions
|
EXP
|
acetonitrile inhibits the reaction [CYP3A23-3A1 protein results in increased metabolism of 7-benzyloxyquinoline]
|
CTD |
PMID:19858067 |
|
NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813
|
|
G
|
Nefh
|
neurofilament heavy chain
|
affects expression
|
EXP
|
acetonitrile affects the expression of NEFH mRNA
|
CTD |
PMID:22954530 |
|
NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417
|
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G
|
Nherf1
|
NHERF family PDZ scaffold protein 1
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increases expression
|
ISO
|
acetonitrile results in increased expression of NHERF1 protein
|
CTD |
PMID:22434383 |
|
NCBI chr10:100,902,165...100,919,265
Ensembl chr10:100,901,227...100,919,579
|
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G
|
Sult1a1
|
sulfotransferase family 1A member 1
|
multiple interactions decreases activity
|
ISO
|
acetonitrile inhibits the reaction [SULT1A1 protein results in increased sulfation of 1-hydroxypyrene]; acetonitrile inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol] acetonitrile results in decreased activity of SULT1A1 protein
|
CTD |
PMID:14570759 |
|
NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131
|
|
G
|
Sult1e1
|
sulfotransferase family 1E member 1
|
multiple interactions
|
ISO
|
acetonitrile promotes the reaction [SULT1E1 protein results in increased sulfation of 1-hydroxypyrene]
|
CTD |
PMID:14570759 |
|
NCBI chr14:20,700,444...20,718,719
Ensembl chr14:20,700,292...20,718,716
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|
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G
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Ache
|
acetylcholinesterase
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decreases activity
|
EXP ISO
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phoxim metabolite results in decreased activity of ACHE protein; phoxim results in decreased activity of ACHE protein
|
CTD |
PMID:15793557 PMID:33497710 PMID:33844597 |
|
NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
|
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G
|
Ar
|
androgen receptor
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multiple interactions
|
ISO
|
phoxim inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]
|
CTD |
PMID:33049310 |
|
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467
|
|
G
|
Arl6ip5
|
ARF like GTPase 6 interacting protein 5
|
affects expression
|
ISO
|
phoxim affects the expression of ARL6IP5 protein
|
CTD |
PMID:15799245 |
|
NCBI chr 4:131,365,320...131,395,311
Ensembl chr 4:131,367,289...131,400,130
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|
G
|
Bche
|
butyrylcholinesterase
|
decreases activity
|
EXP
|
phoxim metabolite results in decreased activity of BCHE protein
|
CTD |
PMID:33497710 |
|
NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760
|
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G
|
Cebpa
|
CCAAT/enhancer binding protein alpha
|
increases expression multiple interactions
|
ISO
|
phoxim results in increased expression of CEBPA protein Fulvestrant inhibits the reaction [phoxim results in increased expression of CEBPA protein]
|
CTD |
PMID:33872936 |
|
NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309
|
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G
|
Cldn4
|
claudin 4
|
decreases expression multiple interactions
|
EXP
|
phoxim results in decreased expression of CLDN4 mRNA Vitamin E inhibits the reaction [phoxim results in decreased expression of CLDN4 mRNA]
|
CTD |
PMID:30003487 |
|
NCBI chr12:27,388,160...27,389,958
Ensembl chr12:27,387,981...27,389,958
|
|
G
|
Cyp2b1
|
cytochrome P450, family 2, subfamily b, polypeptide 1
|
increases expression
|
EXP
|
phoxim results in increased expression of CYP2B1 mRNA
|
CTD |
PMID:36356836 |
|
NCBI chr 1:90,646,098...90,669,762
|
|
G
|
Esr1
|
estrogen receptor 1
|
multiple interactions affects binding
|
ISO
|
phoxim binds to and results in increased activity of ESR1 protein phoxim binds to ESR1 protein
|
CTD |
PMID:33049310 PMID:33872936 |
|
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
|
|
G
|
Fas
|
Fas cell surface death receptor
|
increases expression multiple interactions
|
ISO
|
phoxim results in increased expression of FAS mRNA Fulvestrant inhibits the reaction [phoxim results in increased expression of FAS mRNA]
|
CTD |
PMID:33872936 |
|
NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104
|
|
G
|
Gpx2
|
glutathione peroxidase 2
|
increases expression multiple interactions
|
EXP
|
phoxim results in increased expression of GPX2 mRNA Vitamin E inhibits the reaction [phoxim results in increased expression of GPX2 mRNA]
|
CTD |
PMID:30003487 |
|
NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862
|
|
G
|
Il1b
|
interleukin 1 beta
|
decreases expression
|
EXP
|
phoxim results in decreased expression of IL1B mRNA
|
CTD |
PMID:30003487 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
|
|
G
|
Il6
|
interleukin 6
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decreases expression multiple interactions
|
EXP
|
phoxim results in decreased expression of IL6 mRNA Vitamin E inhibits the reaction [phoxim results in decreased expression of IL6 mRNA]
|
CTD |
PMID:30003487 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
|
|
G
|
Irs2
|
insulin receptor substrate 2
|
decreases expression
|
EXP
|
phoxim results in decreased expression of IRS2 mRNA
|
CTD |
PMID:30090575 |
|
NCBI chr16:85,190,310...85,214,543
Ensembl chr16:85,190,111...85,214,543
|
|
G
|
Lpl
|
lipoprotein lipase
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increases expression multiple interactions
|
ISO
|
phoxim results in increased expression of LPL mRNA Fulvestrant inhibits the reaction [phoxim results in increased expression of LPL mRNA]
|
CTD |
PMID:33872936 |
|
NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107
|
|
G
|
Nfe2l2
|
NFE2 like bZIP transcription factor 2
|
increases expression
|
EXP
|
phoxim results in increased expression of NFE2L2 mRNA
|
CTD |
PMID:30003487 |
|
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
|
|
G
|
Nr1i2
|
nuclear receptor subfamily 1, group I, member 2
|
multiple interactions
|
ISO
|
phoxim binds to and results in increased activity of NR1I2 protein
|
CTD |
PMID:33049310 |
|
NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
|
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G
|
Ocln
|
occludin
|
multiple interactions decreases expression
|
EXP
|
Vitamin E inhibits the reaction [phoxim results in decreased expression of OCLN mRNA]
|
CTD |
PMID:30003487 |
|
NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411
|
|
G
|
Plin1
|
perilipin 1
|
multiple interactions increases expression
|
ISO
|
Fulvestrant inhibits the reaction [phoxim results in increased expression of PLIN1 protein]; tolclofos-methyl inhibits the reaction [phoxim results in increased expression of PLIN1 protein]
|
CTD |
PMID:33872936 |
|
NCBI chr 1:143,073,612...143,086,199
Ensembl chr 1:143,074,214...143,086,206
|
|
G
|
Pparg
|
peroxisome proliferator-activated receptor gamma
|
multiple interactions increases expression
|
ISO
|
phoxim binds to and results in increased activity of PPARG protein Fulvestrant inhibits the reaction [phoxim results in increased expression of PPARG protein]; phoxim binds to and results in increased activity of PPARG protein
|
CTD |
PMID:33049310 PMID:33872936 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
|
|
G
|
Thra
|
thyroid hormone receptor alpha
|
multiple interactions
|
ISO
|
phoxim binds to and results in decreased activity of THRA protein
|
CTD |
PMID:33049310 |
|
NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions increases expression
|
EXP
|
Vitamin E inhibits the reaction [phoxim results in increased expression of TNF protein] phoxim results in increased expression of TNF mRNA; phoxim results in increased expression of TNF protein
|
CTD |
PMID:30003487 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
|
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G
|
Tp53
|
tumor protein p53
|
affects activity
|
ISO
|
phoxim metabolite affects the activity of TP53 protein
|
CTD |
PMID:35435491 |
|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
|
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