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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carbamate insecticide
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Accession:CHEBI:38461 term browser browse the term
Definition:Derivatives of carbamic acid with insecticidal properties of general formula ROC(=O)NR(1)R(2), where ROH is an alcohol, oxime, or phenol and R(1) is hydrogen or methyl. Like organophosphate insecticides, they are cholinesterase inhibitors, but carbamate insecticides differ in action from the organophosphates in that the inhibitory effect on cholinesterase is generally brief.
Synonyms:related_synonym: carbamate insecticides


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aldicarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP
ISO
Aldicarb results in decreased activity of ACHE protein CTD PMID:8134223, PMID:14644616, PMID:16256972, PMID:21251949, PMID:23962483, PMID:27132127 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP Aldicarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP Aldicarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Aldicarb inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Aldicarb results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Nefh neurofilament heavy increases phosphorylation ISO Aldicarb results in increased phosphorylation of NEFH protein CTD PMID:16256972 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nrxn1 neurexin 1 multiple interactions ISO NRXN1 protein affects the reaction [NLG-1 results in increased susceptibility to Aldicarb]; NRXN1 protein affects the reaction [NRX-1 results in decreased susceptibility to Aldicarb] CTD PMID:23638761 NCBI chr 6:13,886,757...15,191,660
Ensembl chr 6:13,886,740...15,191,660
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Aldicarb inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO
EXP
[Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to Aldicarb; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Aldicarb CTD PMID:27132127 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Vpreb1 V-set pre-B cell surrogate light chain 1 decreases expression ISO Aldicarb results in decreased expression of VPREB1 mRNA CTD PMID:25424538 NCBI chr11:88,376,256...88,377,133
Ensembl chr11:88,376,256...88,377,133
JBrowse link
aminocarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO aminocarb results in decreased activity of ACHE protein CTD PMID:2086312 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
bendiocarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO
EXP
bendiocarb results in decreased activity of ACHE protein CTD PMID:14644616, PMID:21251949 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP bendiocarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP bendiocarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO bendiocarb inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO bendiocarb results in increased activity of NFE2L2 protein CTD PMID:20143881 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Pgr progesterone receptor multiple interactions ISO bendiocarb inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
benfuracarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
increases expression
ISO benfuracarb results in increased activity of CYP2B6 protein
benfuracarb results in increased expression of CYP2B6 mRNA
CTD PMID:22310298 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases oxidation ISO CYP2C19 protein results in increased oxidation of benfuracarb CTD PMID:24016712 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression
increases activity
ISO benfuracarb results in increased expression of NR1I3 mRNA
benfuracarb results in increased activity of NR1I3 protein
CTD PMID:22310298, PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
carbaryl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
[Carbaryl co-treated with Dichlorvos] results in decreased activity of ACHE protein; Obidoxime Chloride promotes the reaction [Carbaryl results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [Carbaryl results in decreased activity of ACHE protein]
[Carbaryl co-treated with Chlorpyrifos] results in decreased activity of ACHE protein
CTD PMID:4859365, PMID:7713347, PMID:14644616, PMID:16256972, PMID:19934164, PMID:21251949, PMID:23418109, PMID:23962483, PMID:25707986 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Agxt alanine--glyoxylate and serine--pyruvate aminotransferase decreases activity EXP Carbaryl results in decreased activity of AGXT protein CTD PMID:2119399 NCBI chr 9:100,281,339...100,291,292
Ensembl chr 9:100,281,339...100,291,291
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO
EXP
AHR protein affects the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; Carbaryl binds to and results in increased activity of AHR protein; Carbaryl inhibits the reaction [beta-Naphthoflavone binds to and results in increased activity of AHR protein] CTD PMID:9169082, PMID:9853009, PMID:17553063 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Alb albumin increases hydrolysis
multiple interactions
EXP
ISO
ALB protein results in increased hydrolysis of Carbaryl
bis(4-nitrophenyl)phosphate inhibits the reaction [ALB protein results in increased hydrolysis of Carbaryl]
CTD PMID:27665777 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ar androgen receptor affects binding EXP Carbaryl binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bche butyrylcholinesterase decreases activity
multiple interactions
EXP Carbaryl results in decreased activity of BCHE protein
[Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein
CTD PMID:20708061, PMID:22649187 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2l11 BCL2 like 11 decreases expression ISO Carbaryl results in decreased expression of BCL2L11 mRNA CTD PMID:27829164 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Casp3 caspase 3 increases expression EXP Carbaryl results in increased expression of CASP3 CTD PMID:27296064 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO Carbaryl results in decreased expression of CEBPA mRNA CTD PMID:27829164 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:59,594,007...59,607,122
Ensembl chr 8:59,592,403...59,607,275
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14644616 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]; Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
increases expression
multiple interactions
ISO
EXP
Carbaryl results in increased activity of CYP1A1 protein
Carbaryl results in increased expression of CYP1A1 mRNA; Carbaryl results in increased expression of CYP1A1 protein
AHR protein affects the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; Methoxsalen inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]
CTD PMID:9169082, PMID:9858662, PMID:11226373 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
decreases activity
ISO
EXP
Carbaryl inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]; Carbaryl inhibits the reaction [CYP1A2 protein results in increased metabolism of Estradiol]
Carbaryl results in increased expression of CYP1A2 protein
Carbaryl results in decreased activity of CYP1A2 protein
CTD PMID:9858662, PMID:16790556 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
increases expression
ISO Carbaryl results in increased activity of CYP2B6 protein
Carbaryl results in increased expression of CYP2B6 mRNA
CTD PMID:22310298 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
ISO Carbaryl inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
Carbaryl results in decreased activity of CYP2E1 protein
CTD PMID:22634058 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Carbaryl results in increased expression of DDIT3 mRNA CTD PMID:11226373 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Carbaryl results in increased expression of DNAJB4 mRNA CTD PMID:27829164 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO Carbaryl results in increased expression of DNAJB9 mRNA CTD PMID:27829164 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression ISO Carbaryl results in increased expression of DNAJC3 mRNA CTD PMID:27829164 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329
JBrowse link
G E2f5 E2F transcription factor 5 decreases expression ISO Carbaryl results in decreased expression of E2F5 mRNA CTD PMID:27829164 NCBI chr 2:88,350,764...88,366,913
Ensembl chr 2:88,351,361...88,366,115
JBrowse link
G Enc1 ectodermal-neural cortex 1 decreases expression ISO Carbaryl results in decreased expression of ENC1 mRNA CTD PMID:27829164 NCBI chr 2:28,049,217...28,061,023
Ensembl chr 2:28,049,217...28,061,029
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Carbaryl binds to and results in decreased activity of ESR1 protein; Carbaryl inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867, PMID:16626760 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
decreases expression
ISO Carbaryl binds to and results in decreased activity of ESR2 protein
Carbaryl results in decreased expression of ESR2 mRNA
CTD PMID:16626760, PMID:27829164 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
decreases expression
ISO Carbaryl results in increased expression of FOS mRNA
Carbaryl results in decreased expression of FOS mRNA
CTD PMID:11226373, PMID:27829164 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxo1 forkhead box O1 decreases expression ISO Carbaryl results in decreased expression of FOXO1 mRNA CTD PMID:27829164 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Carbaryl inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]; Carbaryl inhibits the reaction [FSHB protein results in increased secretion of Progesterone] CTD PMID:16413094 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity
multiple interactions
EXP Carbaryl results in increased activity of G6PD protein
[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein; Plant Extracts inhibits the reaction [[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein]
CTD PMID:27214522 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta decreases expression ISO Carbaryl results in decreased expression of GADD45B mRNA CTD PMID:27829164 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Carbaryl results in increased expression of GCLM mRNA CTD PMID:27829164 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpx5 glutathione peroxidase 5 increases expression ISO Carbaryl results in increased expression of GPX5 mRNA CTD PMID:27829164 NCBI chr17:45,508,657...45,518,686
Ensembl chr17:45,467,015...45,518,686
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Carbaryl results in increased expression of HERPUD1 mRNA CTD PMID:27829164 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Carbaryl results in increased expression of HMOX1 mRNA CTD PMID:27829164 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Carbaryl results in increased expression of HSPA5 mRNA CTD PMID:11226373, PMID:27829164 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 protein] CTD PMID:15907790, PMID:18177342 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Carbaryl analog results in decreased susceptibility to IL2 protein; Carbaryl results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Kyat1 kynurenine aminotransferase 1 decreases activity EXP Carbaryl results in decreased activity of KYAT1 protein CTD PMID:2119399 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
JBrowse link
G Mitf melanocyte inducing transcription factor decreases expression ISO Carbaryl results in decreased expression of MITF mRNA CTD PMID:27829164 NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
JBrowse link
G Mtnr1a melatonin receptor 1A affects binding
multiple interactions
ISO Carbaryl binds to MTNR1A protein
Carbaryl inhibits the reaction [Melatonin binds to MTNR1A protein]
CTD PMID:28027439 NCBI chr16:50,339,358...50,358,809
Ensembl chr16:50,339,358...50,358,809
JBrowse link
G Mtnr1b melatonin receptor 1B affects binding
multiple interactions
ISO Carbaryl binds to MTNR1B protein
Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]; Guanosine Triphosphate inhibits the reaction [Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]]
CTD PMID:28027439 NCBI chr 8:14,359,270...14,373,894
Ensembl chr 8:14,359,270...14,373,894
JBrowse link
G Nefh neurofilament heavy increases phosphorylation ISO Carbaryl results in increased phosphorylation of NEFH protein CTD PMID:16256972 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Carbaryl inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein] CTD PMID:15907790, PMID:17015962 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Dithiothreitol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Mercaptoethanol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:15907790 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
increases activity
ISO
EXP
Carbaryl results in increased expression of NR1I2 mRNA
Carbaryl results in increased activity of NR1I2 protein
CTD PMID:22310298, PMID:27665777 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity EXP Carbaryl results in increased activity of NR1I3 protein CTD PMID:27665777 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Carbaryl inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases activity EXP Carbaryl results in decreased activity of PNPLA6 protein CTD PMID:7713347 NCBI chr12:2,068,749...2,098,139
Ensembl chr12:2,069,959...2,097,904
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity EXP Carbaryl results in increased activity of PPARA protein CTD PMID:27665777 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Carbaryl inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:15907790 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
decreases expression
ISO Carbaryl inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]
Carbaryl results in decreased expression of STAR mRNA
CTD PMID:16413094 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases activity ISO
EXP
Carbaryl results in decreased activity of TDO2 protein CTD PMID:2119399, PMID:2547861 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO Carbaryl results in increased expression of TGFB2 mRNA CTD PMID:27829164 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions
affects binding
ISO Carbaryl binds to and results in decreased activity of THRB protein
Carbaryl binds to THRB protein
CTD PMID:18584933, PMID:28973306 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tpo thyroid peroxidase increases activity ISO Carbaryl results in increased activity of TPO protein CTD PMID:21809831 NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855
JBrowse link
G Wnt6 Wnt family member 6 decreases expression ISO Carbaryl results in decreased expression of WNT6 mRNA CTD PMID:27829164 NCBI chr 9:82,033,543...82,047,172
Ensembl chr 9:82,033,543...82,047,166
JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO Carbaryl results in increased expression of XBP1 mRNA CTD PMID:27829164 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
carbofuran term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A4galt alpha 1,4-galactosyltransferase (P blood group) affects response to substance ISO A4GALT gene SNP affects the susceptibility to Carbofuran CTD PMID:22919386 NCBI chr 7:124,085,832...124,110,440
Ensembl chr 7:124,085,834...124,089,385
JBrowse link
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase increases expression EXP Carbofuran results in increased expression of ABHD2 mRNA CTD PMID:20211217 NCBI chr 1:140,998,240...141,087,405
Ensembl chr 1:140,998,240...141,087,405
JBrowse link
G Ache acetylcholinesterase decreases activity ISO
EXP
Carbofuran results in decreased activity of ACHE protein CTD PMID:7966439, PMID:10918524, PMID:19934164, PMID:22209767, PMID:22807346, PMID:23611293, PMID:23962483, PMID:28725974 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Adam8 ADAM metallopeptidase domain 8 increases expression EXP Carbofuran results in increased expression of ADAM8 mRNA CTD PMID:20211217 NCBI chr 1:212,317,510...212,332,895
Ensembl chr 1:212,317,848...212,330,349
JBrowse link
G Alb albumin affects binding ISO Carbofuran binds to ALB protein CTD PMID:27657490 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP Carbofuran results in increased expression of BAX protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased expression of BAX protein]
CTD PMID:28982980, PMID:30471306 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcat1 branched chain amino acid transaminase 1 increases expression EXP Carbofuran results in increased expression of BCAT1 mRNA CTD PMID:20211217 NCBI chr 4:179,259,305...179,340,021
Ensembl chr 4:179,259,308...179,339,795
JBrowse link
G Bche butyrylcholinesterase decreases activity
multiple interactions
ISO
EXP
Carbofuran results in decreased activity of BCHE protein
[Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein
CTD PMID:17364237, PMID:22209767, PMID:22649187 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Carbofuran results in decreased expression of BCL2 protein CTD PMID:30471306 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 decreases expression
multiple interactions
increases expression
EXP
ISO
Carbofuran results in decreased expression of CASP3 protein modified form
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased expression of CASP3 protein modified form]
Carbofuran results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:22240977, PMID:25564422, PMID:28982980, PMID:30471306 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP Plant Extracts inhibits the reaction [Carbofuran results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Carbofuran results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Carbofuran results in decreased activity of CAT protein] CTD PMID:22807346, PMID:24865641, PMID:31334637, PMID:31696704 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression EXP Carbofuran results in increased expression of CCL7 mRNA CTD PMID:20211217 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
EXP Carbofuran results in decreased expression of CCND1 mRNA; Carbofuran results in decreased expression of CCND1 protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in decreased expression of CCND1 protein]
CTD PMID:28982980 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 increases expression EXP Carbofuran results in increased expression of CCR1 mRNA CTD PMID:20211217 NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201
JBrowse link
G Cd14 CD14 molecule increases expression EXP Carbofuran results in increased expression of CD14 mRNA CTD PMID:20211217 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cdk7 cyclin-dependent kinase 7 affects response to substance ISO CDK7 gene SNP affects the susceptibility to Carbofuran CTD PMID:22102698 NCBI chr 2:30,710,642...30,735,522
Ensembl chr 2:30,710,643...30,735,514
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
EXP 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased expression of CDKN1A protein]
Carbofuran results in increased expression of CDKN1A mRNA; Carbofuran results in increased expression of CDKN1A protein
CTD PMID:28982980 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Ch25h cholesterol 25-hydroxylase increases expression EXP Carbofuran results in increased expression of CH25H mRNA CTD PMID:20211217 NCBI chr 1:252,807,062...252,811,409
Ensembl chr 1:252,807,065...252,808,380
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase decreases expression EXP Carbofuran results in decreased expression of CNP mRNA; Carbofuran results in decreased expression of CNP protein CTD PMID:28982980, PMID:30471306 NCBI chr10:88,490,798...88,497,357
Ensembl chr10:88,490,798...88,497,356
JBrowse link
G Crem cAMP responsive element modulator increases expression EXP Carbofuran results in increased expression of CREM mRNA CTD PMID:20211217 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases hydroxylation ISO CYP1A2 protein results in increased hydroxylation of Carbofuran CTD PMID:15560889 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
increases expression
ISO Carbofuran results in increased activity of CYP2B6 protein
Carbofuran results in increased expression of CYP2B6 mRNA
CTD PMID:22310298 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases hydroxylation ISO CYP2C19 protein results in increased hydroxylation of Carbofuran CTD PMID:15560889 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Dcx doublecortin decreases expression
multiple interactions
EXP Carbofuran results in decreased expression of DCX mRNA; Carbofuran results in decreased expression of DCX protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in decreased expression of DCX protein]
CTD PMID:22240977, PMID:28982980 NCBI chr  X:115,098,675...115,175,515
Ensembl chr  X:115,098,675...115,175,299
JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression EXP Carbofuran results in increased expression of FABP3 protein CTD PMID:19854236 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565
JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb increases expression EXP Carbofuran results in increased expression of FCGR2B mRNA CTD PMID:20211217 NCBI chr13:89,329,298...89,343,916
Ensembl chr13:89,327,794...89,433,815
JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Carbofuran results in increased expression of FHL1 mRNA CTD PMID:20211217 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression EXP Carbofuran results in increased expression of FOSL1 mRNA CTD PMID:20211217 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
increases expression
EXP Carbofuran results in decreased expression of GFAP protein
Carbofuran results in increased expression of GFAP mRNA
CTD PMID:22240977, PMID:28982980 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
EXP Plant Extracts inhibits the reaction [Carbofuran results in increased activity of GPT protein]; Silymarin inhibits the reaction [Carbofuran results in increased activity of GPT protein] CTD PMID:31334637, PMID:31696704 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 decreases expression EXP Carbofuran results in decreased expression of GRIA2 protein CTD PMID:28725974 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression EXP Carbofuran results in increased expression of HAMP mRNA CTD PMID:20211217 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 increases expression EXP Carbofuran results in increased expression of HSPA2 mRNA CTD PMID:20211217 NCBI chr 6:99,433,575...99,436,288
Ensembl chr 6:99,433,550...99,436,289
JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Carbofuran results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Klhl40 kelch-like family member 40 increases expression EXP Carbofuran results in increased expression of KLHL40 mRNA CTD PMID:20211217 NCBI chr 8:130,416,265...130,421,871
Ensembl chr 8:130,416,355...130,421,871
JBrowse link
G Klhl41 kelch-like family member 41 increases expression EXP Carbofuran results in increased expression of KLHL41 mRNA CTD PMID:20211217 NCBI chr 3:55,910,177...55,923,303
Ensembl chr 3:55,910,177...55,923,303
JBrowse link
G Ldlr low density lipoprotein receptor affects response to substance ISO LDLR gene SNP affects the susceptibility to Carbofuran CTD PMID:22919386 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Carbofuran results in increased expression of LMCD1 mRNA CTD PMID:20211217 NCBI chr 4:144,192,989...144,252,554
Ensembl chr 4:144,192,989...144,252,551
JBrowse link
G Mag myelin-associated glycoprotein decreases expression EXP Carbofuran results in decreased expression of MAG mRNA; Carbofuran results in decreased expression of MAG protein CTD PMID:30471306 NCBI chr 1:89,345,325...89,360,905
Ensembl chr 1:89,345,429...89,360,733
JBrowse link
G Mbp myelin basic protein decreases expression EXP Carbofuran results in decreased expression of MBP mRNA; Carbofuran results in decreased expression of MBP protein CTD PMID:28982980, PMID:30471306 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mtnr1a melatonin receptor 1A affects binding
multiple interactions
ISO Carbofuran binds to MTNR1A protein
Carbofuran inhibits the reaction [Melatonin binds to MTNR1A protein]
CTD PMID:28027439 NCBI chr16:50,339,358...50,358,809
Ensembl chr16:50,339,358...50,358,809
JBrowse link
G Mtnr1b melatonin receptor 1B affects binding
multiple interactions
ISO Carbofuran binds to MTNR1B protein
Carbofuran inhibits the reaction [Melatonin binds to MTNR1B protein]; Guanosine Triphosphate inhibits the reaction [Carbofuran inhibits the reaction [Melatonin binds to MTNR1B protein]]
CTD PMID:28027439 NCBI chr 8:14,359,270...14,373,894
Ensembl chr 8:14,359,270...14,373,894
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions
EXP
ISO
Carbofuran results in increased expression of MYC mRNA
Carbofuran results in decreased stability of and results in increased degradation of and results in increased mutagenesis of MYC gene
CTD PMID:20211217, PMID:22445671 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myl1 myosin, light chain 1 increases expression EXP Carbofuran results in increased expression of MYL1 protein CTD PMID:19854236 NCBI chr 9:73,937,820...73,958,480
Ensembl chr 9:73,937,823...73,958,480
JBrowse link
G Myrf myelin regulatory factor decreases expression EXP Carbofuran results in decreased expression of MYRF mRNA CTD PMID:30471306 NCBI chr 1:226,260,558...226,292,650
Ensembl chr 1:226,260,558...226,292,480
JBrowse link
G Nes nestin decreases expression EXP Carbofuran results in decreased expression of NES mRNA CTD PMID:22240977, PMID:28982980 NCBI chr 2:187,343,109...187,352,972
Ensembl chr 2:187,344,056...187,352,969
JBrowse link
G Neurod1 neuronal differentiation 1 decreases expression EXP Carbofuran results in decreased expression of NEUROD1 mRNA CTD PMID:22240977, PMID:28982980 NCBI chr 3:66,414,314...66,417,617
Ensembl chr 3:66,414,308...66,417,741
JBrowse link
G Neurog2 neurogenin 2 decreases expression EXP Carbofuran results in decreased expression of NEUROG2 mRNA CTD PMID:28982980 NCBI chr 2:231,962,517...231,963,441
Ensembl chr 2:231,962,517...231,963,308
JBrowse link
G Nrg1 neuregulin 1 decreases expression EXP Carbofuran results in decreased expression of NRG1 mRNA CTD PMID:28982980 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Olig1 oligodendrocyte transcription factor 1 decreases expression EXP Carbofuran results in decreased expression of OLIG1 mRNA CTD PMID:28982980 NCBI chr11:31,428,377...31,430,519
Ensembl chr11:31,428,358...31,430,517
JBrowse link
G Olig2 oligodendrocyte transcription factor 2 decreases expression EXP Carbofuran results in decreased expression of OLIG2 mRNA; Carbofuran results in decreased expression of OLIG2 protein CTD PMID:30471306 NCBI chr11:31,389,514...31,392,890
Ensembl chr11:31,389,514...31,392,890
JBrowse link
G Pax6 paired box 6 decreases expression EXP Carbofuran results in decreased expression of PAX6 mRNA CTD PMID:28982980 NCBI chr 3:95,700,241...95,728,682
Ensembl chr 3:95,707,386...95,728,624
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha decreases expression EXP Carbofuran results in decreased expression of PDGFRA mRNA; Carbofuran results in decreased expression of PDGFRA protein CTD PMID:30471306 NCBI chr14:35,527,926...35,581,130
Ensembl chr14:35,527,927...35,581,031
JBrowse link
G Pla2g4a phospholipase A2 group IVA increases expression EXP Carbofuran results in increased expression of PLA2G4A mRNA CTD PMID:20211217 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Plau plasminogen activator, urokinase increases expression EXP Carbofuran results in increased expression of PLAU mRNA CTD PMID:20211217 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Plp1 proteolipid protein 1 decreases expression EXP Carbofuran results in decreased expression of PLP1 mRNA; Carbofuran results in decreased expression of PLP1 protein CTD PMID:30471306 NCBI chr  X:107,494,326...107,511,355
Ensembl chr  X:107,496,072...107,511,348
JBrowse link
G Pvr PVR cell adhesion molecule increases expression EXP Carbofuran results in increased expression of PVR mRNA CTD PMID:20211217 NCBI chr 1:80,820,306...80,835,712
Ensembl chr 1:80,820,050...80,835,701
JBrowse link
G Rbfox3 RNA binding fox-1 homolog 3 decreases expression
multiple interactions
EXP Carbofuran results in decreased expression of RBFOX3 protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in decreased expression of RBFOX3 protein]
CTD PMID:28982980 NCBI chr10:107,517,916...107,850,764
Ensembl chr10:107,516,995...107,539,658
JBrowse link
G Reg3b regenerating family member 3 beta increases expression EXP Carbofuran results in increased expression of REG3B mRNA CTD PMID:20211217 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G Rnd1 Rho family GTPase 1 increases expression EXP Carbofuran results in increased expression of RND1 mRNA CTD PMID:20211217 NCBI chr 7:140,349,138...140,356,209
Ensembl chr 7:140,349,138...140,356,209
JBrowse link
G S100b S100 calcium binding protein B increases expression EXP Carbofuran results in increased expression of S100B mRNA; Carbofuran results in increased expression of S100B protein CTD PMID:28982980, PMID:30471306 NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
JBrowse link
G Serpine1 serpin family E member 1 increases expression EXP Carbofuran results in increased expression of SERPINE1 mRNA CTD PMID:20211217 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Smad2 SMAD family member 2 increases expression
multiple interactions
increases phosphorylation
EXP Carbofuran results in increased expression of SMAD2 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased phosphorylation of SMAD2 protein]
CTD PMID:28982980 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 increases expression
multiple interactions
increases phosphorylation
EXP Carbofuran results in increased expression of SMAD3 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased phosphorylation of SMAD3 protein]
CTD PMID:28982980 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smad7 SMAD family member 7 decreases expression EXP Carbofuran results in decreased expression of SMAD7 mRNA; Carbofuran results in decreased expression of SMAD7 protein CTD PMID:28982980 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 decreases expression EXP Carbofuran results in decreased expression of SMURF2 mRNA CTD PMID:28982980 NCBI chr10:95,018,050...95,118,107
Ensembl chr10:95,018,059...95,062,987
JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression EXP Carbofuran results in decreased expression of SOX2 protein CTD PMID:22240977 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP Carbofuran results in increased expression of SPP1 mRNA CTD PMID:20211217 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression EXP Carbofuran results in increased expression of STAT3 mRNA CTD PMID:22240977, PMID:28982980 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression EXP Carbofuran results in increased expression of TGFB1 mRNA; Carbofuran results in increased expression of TGFB1 protein CTD PMID:28982980 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Carbofuran results in increased expression of TGFB2 mRNA CTD PMID:20211217 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 increases expression EXP Carbofuran results in increased expression of TIAM1 mRNA CTD PMID:20211217 NCBI chr11:29,931,083...30,061,173
Ensembl chr11:29,933,163...30,051,103
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Carbofuran results in increased expression of TIMP1 mRNA CTD PMID:20211217 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnni3 troponin I3, cardiac type increases expression EXP Carbofuran results in increased expression of TNNI3 protein CTD PMID:19854236 NCBI chr 1:72,882,806...72,886,490
Ensembl chr 1:72,882,806...72,886,488
JBrowse link
G Tnnt2 troponin T2, cardiac type increases expression EXP Carbofuran results in increased expression of TNNT2 protein CTD PMID:19854236 NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Carbofuran results in decreased stability of and results in increased degradation of and results in increased mutagenesis of TP53 gene CTD PMID:22445671 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tubb3 tubulin, beta 3 class III decreases expression EXP Carbofuran results in decreased expression of TUBB3 mRNA CTD PMID:28982980 NCBI chr19:56,220,759...56,229,813
Ensembl chr19:56,220,755...56,229,813
JBrowse link
G Tubb6 tubulin, beta 6 class V increases expression EXP Carbofuran results in increased expression of TUBB6 mRNA CTD PMID:20211217 NCBI chr18:63,130,542...63,140,181
Ensembl chr18:63,130,542...63,140,181
JBrowse link
G Uck2 uridine-cytidine kinase 2 increases expression EXP Carbofuran results in increased expression of UCK2 mRNA CTD PMID:20211217 NCBI chr13:85,376,716...85,443,976
Ensembl chr13:85,376,716...85,443,976
JBrowse link
G Vcan versican increases expression
decreases expression
EXP Carbofuran results in increased expression of VCAN mRNA
Carbofuran results in decreased expression of VCAN mRNA
CTD PMID:20211217, PMID:30471306 NCBI chr 2:18,490,102...18,587,340
Ensembl chr 2:18,490,102...18,565,842
JBrowse link
carbosulfan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP carbosulfan results in decreased activity of ACHE protein CTD PMID:3710030 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
increases metabolic processing
increases expression
ISO carbosulfan results in increased activity of CYP2B6 protein
CYP2B6 protein results in increased metabolism of carbosulfan
carbosulfan results in increased expression of CYP2B6 mRNA
CTD PMID:20307514, PMID:22310298 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO CYP3A5 protein results in increased metabolism of carbosulfan CTD PMID:20307514 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression ISO carbosulfan results in increased expression of NR1I3 mRNA CTD PMID:22310298 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
ethiofencarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO croneton inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein] CTD PMID:26647222 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
formetanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP formetanate results in decreased activity of ACHE protein CTD PMID:19934164, PMID:21251949 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP [Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein CTD PMID:22649187 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression ISO formetanate results in decreased expression of HSPA1A protein CTD PMID:16271832 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO formetanate results in increased expression of HSPA5 protein CTD PMID:16271832 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO formetanate results in decreased expression of HSPA8 protein CTD PMID:16271832 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO formetanate results in increased activity of NFE2L2 protein CTD PMID:20143881 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
furathiocarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
increases activity
ISO deltanit results in increased expression of CYP2B6 mRNA
deltanit results in increased activity of CYP2B6 protein
CTD PMID:22310298 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression ISO deltanit results in increased expression of NR1I3 mRNA CTD PMID:22310298 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
metolcarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Thrb thyroid hormone receptor beta affects binding ISO metolcarb binds to THRB protein CTD PMID:28973306 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
oxamyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP
ISO
oxamyl results in decreased activity of ACHE protein CTD PMID:19934164, PMID:21251949, PMID:27132127 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP [Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein CTD PMID:22649187 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO oxamyl inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Pgr progesterone receptor multiple interactions ISO oxamyl inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO
EXP
[Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to oxamyl; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to oxamyl
[Calcium results in increased activity of PON1 protein] which affects the susceptibility to oxamyl; [Egtazic Acid results in decreased activity of PON1 protein] which affects the susceptibility to oxamyl
CTD PMID:27132127 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
pirimicarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity ISO pirimicarb results in increased activity of CYP19A1 protein CTD PMID:11884232 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO pirimicarb results in decreased expression of ESR1 mRNA CTD PMID:15261991 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression ISO pirimicarb results in decreased expression of HSPA1A protein CTD PMID:16271832 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO pirimicarb results in increased expression of HSPA5 protein CTD PMID:16271832 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO pirimicarb results in decreased expression of HSPA8 protein CTD PMID:16271832 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspb2 heat shock protein family B (small) member 2 decreases expression ISO pirimicarb results in decreased expression of HSPB2 protein CTD PMID:16271832 NCBI chr 8:55,176,648...55,178,227
Ensembl chr 8:55,176,847...55,177,818
JBrowse link
G Lep leptin multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lepr leptin receptor multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in decreased expression of LEPR mRNA CTD PMID:29321614 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Nmb neuromedin B multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in decreased expression of NMB mRNA CTD PMID:29321614 NCBI chr 1:142,721,263...142,724,646
Ensembl chr 1:142,721,002...142,724,511
JBrowse link
G Nmbr neuromedin B receptor multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of NMBR mRNA CTD PMID:29321614 NCBI chr 1:8,933,744...8,945,850
Ensembl chr 1:8,933,831...8,944,987
JBrowse link
G Npy1r neuropeptide Y receptor Y1 multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of NPY1R mRNA CTD PMID:29321614 NCBI chr16:24,779,480...24,789,131
Ensembl chr16:24,779,477...24,788,740
JBrowse link
propoxur term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
Obidoxime Chloride promotes the reaction [Propoxur results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [Propoxur results in decreased activity of ACHE protein] CTD PMID:14644616, PMID:19934164, PMID:21251949, PMID:23962483 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP [Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein CTD PMID:22649187 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP [Propoxur co-treated with Permethrin] results in increased activity of CAT protein; Melatonin inhibits the reaction [Propoxur results in decreased activity of CAT protein] CTD PMID:24733834, PMID:28456543 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP Propoxur results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP Propoxur results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Propoxur inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Propoxur inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
thiodicarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO
EXP
thiodicarb results in decreased activity of ACHE protein CTD PMID:21251949 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pesticide 16263
          insecticide 13436
            carbamate insecticide 142
              XMC 0
              alanycarb 0
              aldicarb 10
              aminocarb 1
              bendiocarb 6
              benfuracarb 3
              butocarboxim 0
              butoxycarboxim 0
              carbanolate 0
              carbaryl 57
              carbofuran 80
              carbosulfan 4
              ethiofencarb 1
              formetanate 6
              furathiocarb 2
              isoprocarb 0
              metolcarb 1
              oxamyl 5
              pirimicarb 11
              propoxur 7
              thiodicarb 1
              thiofanox 0
              trimethacarb 0
              xylylcarb 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        inhibitor 18221
          enzyme inhibitor 18148
            EC 3.* (hydrolase) inhibitor 17643
              EC 3.1.* (ester hydrolase) inhibitor 12872
                EC 3.1.1.* (carboxylic ester hydrolase) inhibitor 8647
                  EC 3.1.1.7 (acetylcholinesterase) inhibitor 6063
                    carbamate insecticide 142
                      XMC 0
                      alanycarb 0
                      aldicarb 10
                      aminocarb 1
                      bendiocarb 6
                      benfuracarb 3
                      butocarboxim 0
                      butoxycarboxim 0
                      carbanolate 0
                      carbaryl 57
                      carbofuran 80
                      carbosulfan 4
                      ethiofencarb 1
                      formetanate 6
                      furathiocarb 2
                      isoprocarb 0
                      metolcarb 1
                      oxamyl 5
                      pirimicarb 11
                      propoxur 7
                      thiodicarb 1
                      thiofanox 0
                      trimethacarb 0
                      xylylcarb 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.