Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:carbamate insecticide
go back to main search page
Accession:CHEBI:38461 term browser browse the term
Definition:Derivatives of carbamic acid with insecticidal properties of general formula ROC(=O)NR1R2, where ROH is an alcohol, oxime, or phenol and R1 is hydrogen or methyl. Like organophosphate insecticides, they are cholinesterase inhibitors, but carbamate insecticides differ in action from the organophosphates in that the inhibitory effect on cholinesterase is generally brief.
Synonyms:related_synonym: carbamate insecticides


show annotations for term's descendants           Sort by:
aldicarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP
ISO 		Aldicarb results in decreased activity of ACHE protein CTD PMID:8134223 PMID:14644616 PMID:16256972 PMID:21251949 PMID:23962483 More... NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions
increases expression 		EXP robinin inhibits the reaction [Aldicarb results in increased expression of AGER mRNA] CTD PMID:39889879 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685 		JBrowse link
G App amyloid beta precursor protein decreases response to substance ISO APP protein modified form results in decreased susceptibility to Aldicarb CTD PMID:34902447 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions 		EXP Aldicarb results in increased expression of BAX protein
robinin inhibits the reaction [Aldicarb results in increased expression of BAX protein] 		CTD PMID:39889879 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions 		EXP Aldicarb results in decreased expression of BCL2 protein
robinin inhibits the reaction [Aldicarb results in decreased expression of BCL2 protein] 		CTD PMID:39889879 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression 		EXP robinin inhibits the reaction [Aldicarb results in increased expression of CASP3 protein] CTD PMID:39889879 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression 		EXP robinin inhibits the reaction [Aldicarb results in increased expression of CASP9 protein] CTD PMID:39889879 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions
decreases activity 		EXP robinin inhibits the reaction [Aldicarb results in decreased activity of CAT protein] CTD PMID:39889879 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression 		EXP robinin inhibits the reaction [Aldicarb results in increased expression of CCL2 mRNA] CTD PMID:39889879 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP Aldicarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:188,501,209...188,535,105 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP Aldicarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:64,313,669...64,333,248 		JBrowse link
G Cst3 cystatin C multiple interactions
increases expression 		EXP robinin inhibits the reaction [Aldicarb results in increased expression of CST3 protein] CTD PMID:39889879 NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:156,790,079...156,793,937 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Aldicarb inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity 		EXP robinin inhibits the reaction [Aldicarb results in decreased activity of GSR protein] CTD PMID:39889879 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions
increases expression 		EXP robinin inhibits the reaction [Aldicarb results in increased expression of HAVCR1 protein] CTD PMID:39889879 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions
increases expression 		EXP robinin inhibits the reaction [Aldicarb results in increased expression of HMGB1 mRNA] CTD PMID:39889879 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases activity 		EXP robinin inhibits the reaction [Aldicarb results in decreased activity of HMOX1 protein] CTD PMID:39889879 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions 		EXP Aldicarb results in increased expression of IL1B mRNA
robinin inhibits the reaction [Aldicarb results in increased expression of IL1B mRNA] 		CTD PMID:39889879 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Aldicarb results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions 		EXP Aldicarb results in increased expression of IL6 mRNA
robinin inhibits the reaction [Aldicarb results in increased expression of IL6 mRNA] 		CTD PMID:39889879 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO Aldicarb promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of MAP2 mRNA] CTD PMID:32949729 NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression
multiple interactions 		EXP Aldicarb results in increased expression of MYD88 mRNA
robinin inhibits the reaction [Aldicarb results in increased expression of MYD88 mRNA] 		CTD PMID:39889879 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230 		JBrowse link
G Nefh neurofilament heavy chain increases phosphorylation ISO Aldicarb results in increased phosphorylation of NEFH protein CTD PMID:16256972 NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417 		JBrowse link
G Nrxn1 neurexin 1 multiple interactions ISO NRXN1 protein affects the reaction [NLG-1 results in increased susceptibility to Aldicarb]; NRXN1 protein affects the reaction [NRX-1 results in decreased susceptibility to Aldicarb] CTD PMID:23638761 NCBI chr 6:8,931,360...10,077,381
Ensembl chr 6:8,935,523...10,077,374 		JBrowse link
G Pax6 paired box 6 multiple interactions ISO Aldicarb inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of PAX6 mRNA] CTD PMID:32949729 NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:112,590,391...112,611,763 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Aldicarb inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO
EXP 		[Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to Aldicarb; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Aldicarb CTD PMID:27132127 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions 		EXP Aldicarb results in increased expression of PTGS2 mRNA
robinin inhibits the reaction [Aldicarb results in increased expression of PTGS2 mRNA] 		CTD PMID:39889879 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression 		EXP robinin inhibits the reaction [Aldicarb results in increased expression of RELA mRNA] CTD PMID:39889879 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Tlr4 toll-like receptor 4 increases expression
multiple interactions 		EXP Aldicarb results in increased expression of TLR4 mRNA
robinin inhibits the reaction [Aldicarb results in increased expression of TLR4 mRNA] 		CTD PMID:39889879 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression 		EXP robinin inhibits the reaction [Aldicarb results in increased expression of TNF mRNA] CTD PMID:39889879 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Vpreb1a V-set pre-B cell surrogate light chain 1A decreases expression ISO Aldicarb results in decreased expression of VPREB1 mRNA CTD PMID:25424538 NCBI chr11:97,631,174...97,632,051
Ensembl chr11:97,629,102...97,632,051 		JBrowse link
aminocarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO aminocarb results in decreased activity of ACHE protein CTD PMID:2086312 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
bendiocarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO
EXP 		bendiocarb results in decreased activity of ACHE protein CTD PMID:14644616 PMID:21251949 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP bendiocarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:188,501,209...188,535,105 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP bendiocarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:64,313,669...64,333,248 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO bendiocarb inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO bendiocarb results in increased activity of NFE2L2 protein CTD PMID:20143881 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO bendiocarb inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
benfuracarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO benfuracarb metabolite results in decreased activity of ACHE protein; benfuracarb results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
increases expression 		ISO benfuracarb results in increased activity of CYP2B6 protein
benfuracarb results in increased expression of CYP2B6 mRNA 		CTD PMID:22310298 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases oxidation ISO CYP2C19 protein results in increased oxidation of benfuracarb CTD PMID:24016712 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity
increases expression
multiple interactions
increases metabolic processing 		ISO benfuracarb results in increased activity of CYP3A4 protein
benfuracarb results in increased expression of CYP3A4 mRNA
[CYP3A4 protein results in increased metabolism of benfuracarb] which results in increased chemical synthesis of Carbofuran 		CTD PMID:22310298 PMID:24016712 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression
increases activity 		ISO benfuracarb results in increased expression of NR1I3 mRNA
benfuracarb results in increased activity of NR1I3 protein 		CTD PMID:22310298 PMID:28927721 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370 		JBrowse link
carbaryl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity 		ISO
EXP 		[Carbaryl co-treated with Dichlorvos] results in decreased activity of ACHE protein; Obidoxime Chloride promotes the reaction [Carbaryl results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [Carbaryl results in decreased activity of ACHE protein]
[Carbaryl co-treated with Chlorpyrifos] results in decreased activity of ACHE protein 		CTD PMID:4859365 PMID:7713347 PMID:14644616 PMID:16256972 PMID:19934164 More... NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Agxt alanine--glyoxylate aminotransferase decreases activity EXP Carbaryl results in decreased activity of AGXT protein CTD PMID:2119399 NCBI chr 9:101,122,793...101,132,746
Ensembl chr 9:101,122,793...101,132,745 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO
EXP 		AHR protein affects the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; Carbaryl binds to and results in increased activity of AHR protein; Carbaryl inhibits the reaction [beta-Naphthoflavone binds to and results in increased activity of AHR protein] CTD PMID:9169082 PMID:9853009 PMID:17553063 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Alb albumin increases hydrolysis
multiple interactions 		EXP
ISO 		ALB protein results in increased hydrolysis of Carbaryl
bis(4-nitrophenyl)phosphate inhibits the reaction [ALB protein results in increased hydrolysis of Carbaryl] 		CTD PMID:27665777 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Ar androgen receptor affects binding EXP Carbaryl binds to AR protein CTD PMID:14565775 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Bche butyrylcholinesterase decreases activity
multiple interactions 		EXP Carbaryl results in decreased activity of BCHE protein
[Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein 		CTD PMID:20708061 PMID:22649187 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760 		JBrowse link
G Bcl2l11 Bcl2-like 11 decreases expression ISO Carbaryl results in decreased expression of BCL2L11 mRNA CTD PMID:27829164 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695 		JBrowse link
G Casp3 caspase 3 increases expression EXP Carbaryl results in increased expression of CASP3 CTD PMID:27296064 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO Carbaryl results in decreased expression of CEBPA mRNA CTD PMID:27829164 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:64,297,755...64,311,412 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:188,501,209...188,535,105 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14644616 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:177,479,091...177,491,326 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]; Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:64,313,669...64,333,248 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
increases expression
multiple interactions 		ISO
EXP 		Carbaryl results in increased activity of CYP1A1 protein
Carbaryl results in increased expression of CYP1A1 mRNA; Carbaryl results in increased expression of CYP1A1 protein
AHR protein affects the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; Methoxsalen inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA] 		CTD PMID:9169082 PMID:9858662 PMID:11226373 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
decreases activity 		ISO
EXP 		Carbaryl inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]; Carbaryl inhibits the reaction [CYP1A2 protein results in increased metabolism of Estradiol]
Carbaryl results in increased expression of CYP1A2 protein
Carbaryl results in decreased activity of CYP1A2 protein 		CTD PMID:9858662 PMID:16790556 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
increases expression 		ISO Carbaryl results in increased activity of CYP2B6 protein
Carbaryl results in increased expression of CYP2B6 mRNA 		CTD PMID:22310298 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity 		ISO Carbaryl inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
Carbaryl results in decreased activity of CYP2E1 protein 		CTD PMID:22634058 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO Carbaryl results in increased expression of CYP3A4 mRNA CTD PMID:22310298 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Carbaryl results in increased expression of DDIT3 mRNA CTD PMID:11226373 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Carbaryl results in increased expression of DNAJB4 mRNA CTD PMID:27829164 NCBI chr 2:243,790,296...243,819,042
Ensembl chr 2:243,790,297...243,819,042 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO Carbaryl results in increased expression of DNAJB9 mRNA CTD PMID:27829164 NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:66,997,842...67,009,344 		JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression ISO Carbaryl results in increased expression of DNAJC3 mRNA CTD PMID:27829164 NCBI chr15:102,432,667...102,475,643
Ensembl chr15:102,432,663...102,475,643 		JBrowse link
G E2f5 E2F transcription factor 5 decreases expression ISO Carbaryl results in decreased expression of E2F5 mRNA CTD PMID:27829164 NCBI chr 2:88,718,567...88,734,143
Ensembl chr 2:88,718,567...88,734,143 		JBrowse link
G Enc1 ectodermal-neural cortex 1 decreases expression ISO Carbaryl results in decreased expression of ENC1 mRNA CTD PMID:27829164 NCBI chr 2:30,285,274...30,297,194
Ensembl chr 2:30,283,736...30,315,721 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Carbaryl binds to and results in decreased activity of ESR1 protein; Carbaryl inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867 PMID:16626760 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
decreases expression 		ISO Carbaryl binds to and results in decreased activity of ESR2 protein
Carbaryl results in decreased expression of ESR2 mRNA 		CTD PMID:16626760 PMID:27829164 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
decreases expression 		ISO Carbaryl results in increased expression of FOS mRNA
Carbaryl results in decreased expression of FOS mRNA 		CTD PMID:11226373 PMID:27829164 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Foxo1 forkhead box O1 decreases expression ISO Carbaryl results in decreased expression of FOXO1 mRNA CTD PMID:27829164 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Carbaryl inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]; Carbaryl inhibits the reaction [FSHB protein results in increased secretion of Progesterone] CTD PMID:16413094 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity
multiple interactions 		EXP Carbaryl results in increased activity of G6PD protein
[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein; Plant Extracts inhibits the reaction [[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein] 		CTD PMID:27214522 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:157,352,373...157,372,144 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta decreases expression ISO Carbaryl results in decreased expression of GADD45B mRNA CTD PMID:27829164 NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Carbaryl results in increased expression of GCLM mRNA CTD PMID:27829164 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003 		JBrowse link
G Gpx5 glutathione peroxidase 5 increases expression ISO Carbaryl results in increased expression of GPX5 mRNA CTD PMID:27829164 NCBI chr17:48,131,853...48,138,801
Ensembl chr17:48,093,895...48,138,801 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B increases expression EXP Carbaryl results in increased expression of GRIN2B protein CTD PMID:28975519 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Carbaryl results in increased expression of HERPUD1 mRNA CTD PMID:27829164 NCBI chr19:10,604,360...10,624,168
Ensembl chr19:10,604,362...10,624,081 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Carbaryl results in increased expression of HMOX1 mRNA CTD PMID:27829164 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Carbaryl results in increased expression of HSPA5 mRNA CTD PMID:11226373 PMID:27829164 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Hspa6l-ps1 heat shock protein family A (Hsp70) member 6 like, pseudogene 1 decreases expression ISO Carbaryl results in decreased expression of HSPA6 mRNA CTD PMID:27829164 NCBI chr13:85,805,911...85,807,052 JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 protein] CTD PMID:15907790 PMID:18177342 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487 		JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Carbaryl analog results in decreased susceptibility to IL2 protein; Carbaryl results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Kyat1 kynurenine aminotransferase 1 decreases activity EXP Carbaryl results in decreased activity of KYAT1 protein CTD PMID:2119399 NCBI chr 3:33,857,407...33,891,153
Ensembl chr 3:33,857,743...33,890,642 		JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO Carbaryl promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of MAP2 mRNA] CTD PMID:32949729 NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459 		JBrowse link
G Mitf melanocyte inducing transcription factor decreases expression ISO Carbaryl results in decreased expression of MITF mRNA CTD PMID:27829164 NCBI chr 4:131,965,676...132,177,790
Ensembl chr 4:131,965,714...132,177,790 		JBrowse link
G Mtnr1a melatonin receptor 1A affects binding
multiple interactions 		ISO Carbaryl binds to MTNR1A protein
Carbaryl inhibits the reaction [Melatonin binds to MTNR1A protein] 		CTD PMID:28027439 NCBI chr16:53,876,964...53,896,421
Ensembl chr16:53,876,964...53,896,421 		JBrowse link
G Mtnr1b melatonin receptor 1B affects binding
multiple interactions 		ISO Carbaryl binds to MTNR1B protein
Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]; Guanosine Triphosphate inhibits the reaction [Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]] 		CTD PMID:28027439 NCBI chr 8:20,919,593...20,934,109
Ensembl chr 8:20,919,593...20,934,109 		JBrowse link
G Nefh neurofilament heavy chain increases phosphorylation ISO Carbaryl results in increased phosphorylation of NEFH protein CTD PMID:16256972 NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Carbaryl inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein] CTD PMID:15907790 PMID:17015962 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Dithiothreitol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Mercaptoethanol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:15907790 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
increases activity 		ISO
EXP 		Carbaryl results in increased expression of NR1I2 mRNA
Carbaryl results in increased activity of NR1I2 protein 		CTD PMID:22310298 PMID:27665777 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity EXP Carbaryl results in increased activity of NR1I3 protein CTD PMID:27665777 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370 		JBrowse link
G Otx2 orthodenticle homeobox 2 multiple interactions ISO Carbaryl inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of OTX2 mRNA] CTD PMID:32949729 NCBI chr15:24,422,876...24,432,709
Ensembl chr15:24,422,876...24,432,472 		JBrowse link
G Pax6 paired box 6 multiple interactions ISO Carbaryl inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of PAX6 mRNA] CTD PMID:32949729 NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:112,590,391...112,611,763 		JBrowse link
G Pdxk pyridoxal kinase decreases activity ISO Carbaryl results in decreased activity of PDXK protein CTD PMID:2547861 NCBI chr20:10,209,975...10,232,012
Ensembl chr20:10,209,832...10,233,780 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Carbaryl inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases activity EXP Carbaryl results in decreased activity of PNPLA6 protein CTD PMID:7713347 NCBI chr12:6,372,284...6,401,632
Ensembl chr12:6,372,293...6,401,631 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions ISO Carbaryl promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in decreased expression of POU5F1 mRNA] CTD PMID:32949729 NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity EXP Carbaryl results in increased activity of PPARA protein CTD PMID:27665777 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Carbaryl inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:15907790 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
decreases expression 		ISO Carbaryl inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]
Carbaryl results in decreased expression of STAR mRNA 		CTD PMID:16413094 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases activity ISO
EXP 		Carbaryl results in decreased activity of TDO2 protein CTD PMID:2119399 PMID:2547861 NCBI chr 2:169,567,656...169,585,586
Ensembl chr 2:169,567,654...169,585,586 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO Carbaryl results in increased expression of TGFB2 mRNA CTD PMID:27829164 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions
affects binding 		ISO Carbaryl binds to and results in decreased activity of THRB protein
Carbaryl binds to THRB protein 		CTD PMID:18584933 PMID:28973306 NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680 		JBrowse link
G Tpo thyroid peroxidase increases activity ISO Carbaryl results in increased activity of TPO protein CTD PMID:21809831 NCBI chr 6:52,425,998...52,495,793
Ensembl chr 6:52,426,010...52,495,793 		JBrowse link
G Wnt6 Wnt family member 6 decreases expression ISO Carbaryl results in decreased expression of WNT6 mRNA CTD PMID:27829164 NCBI chr 9:83,778,552...83,792,186
Ensembl chr 9:83,778,552...83,792,186 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO Carbaryl results in increased expression of XBP1 mRNA CTD PMID:27829164 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
carbofuran term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A4galt alpha 1,4-galactosyltransferase affects response to substance ISO A4GALT gene SNP affects the susceptibility to Carbofuran CTD PMID:22919386 NCBI chr 7:116,248,571...116,272,917
Ensembl chr 7:116,247,880...116,273,171 		JBrowse link
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase increases expression EXP Carbofuran results in increased expression of ABHD2 mRNA CTD PMID:20211217 NCBI chr 1:142,626,748...142,707,892
Ensembl chr 1:142,626,732...142,712,674 		JBrowse link
G Ache acetylcholinesterase decreases activity ISO
EXP 		Carbofuran results in decreased activity of ACHE protein CTD PMID:7966439 PMID:10918524 PMID:19934164 PMID:22209767 PMID:22807346 More... NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Adam8 ADAM metallopeptidase domain 8 increases expression EXP Carbofuran results in increased expression of ADAM8 mRNA CTD PMID:20211217 NCBI chr 1:204,206,206...204,218,988
Ensembl chr 1:204,206,199...204,218,485 		JBrowse link
G Alb albumin affects binding
multiple interactions
increases secretion 		ISO
EXP 		Carbofuran binds to ALB protein
Plant Extracts inhibits the reaction [Carbofuran results in increased secretion of ALB protein]; Silymarin inhibits the reaction [Carbofuran results in increased secretion of ALB protein] 		CTD PMID:27657490 PMID:34264070 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions 		EXP Carbofuran results in increased expression of BAX protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased expression of BAX protein] 		CTD PMID:28982980 PMID:30471306 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcat1 branched chain amino acid transaminase 1 increases expression EXP Carbofuran results in increased expression of BCAT1 mRNA CTD PMID:20211217 NCBI chr 4:179,695,662...179,777,973
Ensembl chr 4:179,695,662...179,777,288 		JBrowse link
G Bche butyrylcholinesterase decreases activity
multiple interactions 		ISO
EXP 		Carbofuran results in decreased activity of BCHE protein
[Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein 		CTD PMID:17364237 PMID:22209767 PMID:22649187 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Carbofuran results in decreased expression of BCL2 protein CTD PMID:30471306 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 decreases expression
multiple interactions
increases expression 		EXP
ISO 		Carbofuran results in decreased expression of CASP3 protein modified form
Carbofuran results in increased cleavage of and results in increased activity of CASP3 protein
Carbofuran results in increased expression of CASP3 protein modified form
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased expression of CASP3 protein modified form] 		CTD PMID:22240977 PMID:25564422 PMID:28982980 PMID:30471306 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cat catalase multiple interactions
decreases activity 		EXP Plant Extracts inhibits the reaction [Carbofuran results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Carbofuran results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Carbofuran results in decreased activity of CAT protein] CTD PMID:22807346 PMID:24865641 PMID:31334637 PMID:31696704 PMID:34264070 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression EXP Carbofuran results in increased expression of CCL7 mRNA CTD PMID:20211217 NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,514,091...67,515,947 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions 		EXP Carbofuran results in decreased expression of CCND1 mRNA; Carbofuran results in decreased expression of CCND1 protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in decreased expression of CCND1 protein] 		CTD PMID:28982980 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 increases expression EXP Carbofuran results in increased expression of CCR1 mRNA CTD PMID:20211217 NCBI chr 8:132,433,711...132,439,266
Ensembl chr 8:132,431,592...132,439,374 		JBrowse link
G Cd14 CD14 molecule increases expression EXP Carbofuran results in increased expression of CD14 mRNA CTD PMID:20211217 NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292 		JBrowse link
G Cdk7 cyclin-dependent kinase 7 affects response to substance ISO CDK7 gene SNP affects the susceptibility to Carbofuran CTD PMID:22102698 NCBI chr 2:33,574,623...33,599,485
Ensembl chr 2:33,574,623...33,599,485 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression 		EXP 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased expression of CDKN1A protein]
Carbofuran results in increased expression of CDKN1A mRNA; Carbofuran results in increased expression of CDKN1A protein 		CTD PMID:28982980 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Ch25h cholesterol 25-hydroxylase increases expression EXP Carbofuran results in increased expression of CH25H mRNA CTD PMID:20211217 NCBI chr 1:241,428,048...241,429,366
Ensembl chr 1:241,331,619...241,431,190 		JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase decreases expression EXP Carbofuran results in decreased expression of CNP mRNA; Carbofuran results in decreased expression of CNP protein CTD PMID:28982980 PMID:30471306 NCBI chr10:86,011,504...86,018,063
Ensembl chr10:86,011,495...86,018,063 		JBrowse link
G Crem cAMP responsive element modulator increases expression EXP Carbofuran results in increased expression of CREM mRNA CTD PMID:20211217 NCBI chr17:58,932,011...59,001,160
Ensembl chr17:58,934,147...59,001,160 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases hydroxylation ISO CYP1A2 protein results in increased hydroxylation of Carbofuran CTD PMID:15560889 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
increases expression 		ISO Carbofuran results in increased activity of CYP2B6 protein
Carbofuran results in increased expression of CYP2B6 mRNA 		CTD PMID:22310298 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases hydroxylation ISO CYP2C19 protein results in increased hydroxylation of Carbofuran CTD PMID:15560889 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases hydroxylation
multiple interactions
increases expression
increases chemical synthesis
increases activity 		ISO CYP3A4 protein results in increased hydroxylation of Carbofuran
[CYP3A4 protein results in increased metabolism of benfuracarb] which results in increased chemical synthesis of Carbofuran; Carbofuran promotes the reaction [CYP3A4 protein affects the metabolism of Testosterone]; Chlorpyrifos inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Carbofuran]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Carbofuran]
Carbofuran results in increased expression of CYP3A4 mRNA
CYP3A4 protein results in increased chemical synthesis of Carbofuran
Carbofuran results in increased activity of CYP3A4 protein 		CTD PMID:15560889 PMID:22310298 PMID:24016712 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Dcx doublecortin decreases expression
multiple interactions 		EXP Carbofuran results in decreased expression of DCX mRNA; Carbofuran results in decreased expression of DCX protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in decreased expression of DCX protein] 		CTD PMID:22240977 PMID:28982980 NCBI chr  X:112,227,455...112,370,291
Ensembl chr  X:112,227,455...112,304,161 		JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression EXP Carbofuran results in increased expression of FABP3 protein CTD PMID:19854236 NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:147,936,119...147,942,881 		JBrowse link
G Fcgr2b Fc gamma receptor 2B increases expression EXP Carbofuran results in increased expression of FCGR2B mRNA CTD PMID:20211217 NCBI chr13:85,725,897...85,740,517
Ensembl chr13:85,725,897...85,740,517 		JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Carbofuran results in increased expression of FHL1 mRNA CTD PMID:20211217 NCBI chr  X:139,592,794...139,652,290
Ensembl chr  X:139,592,604...139,652,282 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression EXP Carbofuran results in increased expression of FOSL1 mRNA CTD PMID:20211217 NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391 		JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
increases expression 		EXP Carbofuran results in decreased expression of GFAP protein
Carbofuran results in increased expression of GFAP mRNA 		CTD PMID:22240977 PMID:28982980 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity 		EXP Plant Extracts inhibits the reaction [Carbofuran results in increased activity of GPT protein]; Silymarin inhibits the reaction [Carbofuran results in increased activity of GPT protein] CTD PMID:19778259 PMID:31334637 PMID:31696704 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 decreases expression EXP Carbofuran results in decreased expression of GRIA2 protein CTD PMID:28725974 NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:168,247,496...168,367,616 		JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression EXP Carbofuran results in increased expression of HAMP mRNA CTD PMID:20211217 NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297 		JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 increases expression EXP Carbofuran results in increased expression of HSPA2 mRNA CTD PMID:20211217 NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:100,864,553...100,867,133 		JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Carbofuran results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Klhl40 kelch-like family member 40 increases expression EXP Carbofuran results in increased expression of KLHL40 mRNA CTD PMID:20211217 NCBI chr 8:130,318,793...130,324,309
Ensembl chr 8:130,318,794...130,326,299 		JBrowse link
G Klhl41 kelch-like family member 41 increases expression EXP Carbofuran results in increased expression of KLHL41 mRNA CTD PMID:20211217 NCBI chr 3:74,842,118...74,855,244 JBrowse link
G Ldlr low density lipoprotein receptor affects response to substance ISO LDLR gene SNP affects the susceptibility to Carbofuran CTD PMID:22919386 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675 		JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Carbofuran results in increased expression of LMCD1 mRNA CTD PMID:20211217 NCBI chr 4:146,948,993...147,007,878
Ensembl chr 4:146,948,958...147,007,875 		JBrowse link
G Mag myelin-associated glycoprotein decreases expression EXP Carbofuran results in decreased expression of MAG mRNA; Carbofuran results in decreased expression of MAG protein CTD PMID:30471306 NCBI chr 1:95,275,728...95,291,133
Ensembl chr 1:95,275,635...95,291,060 		JBrowse link
G Mbp myelin basic protein decreases expression EXP Carbofuran results in decreased expression of MBP mRNA; Carbofuran results in decreased expression of MBP protein CTD PMID:28982980 PMID:30471306 NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174 		JBrowse link
G Mtnr1a melatonin receptor 1A affects binding
multiple interactions 		ISO Carbofuran binds to MTNR1A protein
Carbofuran inhibits the reaction [Melatonin binds to MTNR1A protein] 		CTD PMID:28027439 NCBI chr16:53,876,964...53,896,421
Ensembl chr16:53,876,964...53,896,421 		JBrowse link
G Mtnr1b melatonin receptor 1B affects binding
multiple interactions 		ISO Carbofuran binds to MTNR1B protein
Carbofuran inhibits the reaction [Melatonin binds to MTNR1B protein]; Guanosine Triphosphate inhibits the reaction [Carbofuran inhibits the reaction [Melatonin binds to MTNR1B protein]] 		CTD PMID:28027439 NCBI chr 8:20,919,593...20,934,109
Ensembl chr 8:20,919,593...20,934,109 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions 		EXP
ISO 		Carbofuran results in increased expression of MYC mRNA
Carbofuran results in decreased stability of and results in increased degradation of and results in increased mutagenesis of MYC gene 		CTD PMID:20211217 PMID:22445671 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Myl1 myosin, light chain 1 increases expression EXP Carbofuran results in increased expression of MYL1 protein CTD PMID:19854236 Ensembl chr 9:75,887,227...75,907,971 JBrowse link
G Myrf myelin regulatory factor decreases expression EXP Carbofuran results in decreased expression of MYRF mRNA CTD PMID:30471306 NCBI chr 1:216,279,057...216,311,155
Ensembl chr 1:216,279,057...216,311,178 		JBrowse link
G Nes nestin decreases expression EXP Carbofuran results in decreased expression of NES mRNA CTD PMID:22240977 PMID:28982980 NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:175,736,551...175,746,228 		JBrowse link
G Neurod1 neuronal differentiation 1 decreases expression EXP Carbofuran results in decreased expression of NEUROD1 mRNA CTD PMID:22240977 PMID:28982980 NCBI chr 3:84,766,483...84,770,454
Ensembl chr 3:84,764,725...84,770,810 		JBrowse link
G Neurog2 neurogenin 2 decreases expression EXP Carbofuran results in decreased expression of NEUROG2 mRNA CTD PMID:28982980 NCBI chr 2:218,767,205...218,769,772
Ensembl chr 2:218,765,949...218,769,784 		JBrowse link
G Nrg1 neuregulin 1 decreases expression EXP Carbofuran results in decreased expression of NRG1 mRNA CTD PMID:28982980 NCBI chr16:65,954,084...67,007,484
Ensembl chr16:65,953,865...66,999,849 		JBrowse link
G Olig1 oligodendrocyte transcription factor 1 decreases expression EXP Carbofuran results in decreased expression of OLIG1 mRNA CTD PMID:28982980 NCBI chr11:44,000,450...44,002,592
Ensembl chr11:44,000,281...44,002,592 		JBrowse link
G Olig2 oligodendrocyte transcription factor 2 decreases expression EXP Carbofuran results in decreased expression of OLIG2 mRNA; Carbofuran results in decreased expression of OLIG2 protein CTD PMID:30471306 NCBI chr11:43,961,585...43,964,961
Ensembl chr11:43,958,940...43,968,634 		JBrowse link
G Pax6 paired box 6 decreases expression EXP Carbofuran results in decreased expression of PAX6 mRNA CTD PMID:28982980 NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:112,590,391...112,611,763 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha decreases expression EXP Carbofuran results in decreased expression of PDGFRA mRNA; Carbofuran results in decreased expression of PDGFRA protein CTD PMID:30471306 NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,360,028...33,408,516 		JBrowse link
G Pla2g4a phospholipase A2 group 4A increases expression EXP Carbofuran results in increased expression of PLA2G4A mRNA CTD PMID:20211217 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641 		JBrowse link
G Plau plasminogen activator, urokinase increases expression EXP Carbofuran results in increased expression of PLAU mRNA CTD PMID:20211217 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030 		JBrowse link
G Plp1 proteolipid protein 1 decreases expression EXP Carbofuran results in decreased expression of PLP1 mRNA; Carbofuran results in decreased expression of PLP1 protein CTD PMID:30471306 NCBI chr  X:104,933,921...104,993,317
Ensembl chr  X:104,975,780...104,993,314 		JBrowse link
G Pvr PVR cell adhesion molecule increases expression EXP Carbofuran results in increased expression of PVR mRNA CTD PMID:20211217 NCBI chr 1:88,689,235...88,704,641
Ensembl chr 1:88,688,981...88,704,630 		JBrowse link
G Rbfox3 RNA binding fox-1 homolog 3 decreases expression
multiple interactions 		EXP Carbofuran results in decreased expression of RBFOX3 protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in decreased expression of RBFOX3 protein] 		CTD PMID:28982980 NCBI chr10:104,218,940...104,655,863
Ensembl chr10:104,218,940...104,551,945 		JBrowse link
G Reg3b regenerating family member 3 beta increases expression EXP Carbofuran results in increased expression of REG3B mRNA CTD PMID:20211217 NCBI chr 4:112,419,776...112,423,014
Ensembl chr 4:112,419,776...112,423,014 		JBrowse link
G Rnd1 Rho family GTPase 1 increases expression EXP Carbofuran results in increased expression of RND1 mRNA CTD PMID:20211217 NCBI chr 7:131,700,321...131,707,392
Ensembl chr 7:131,700,321...131,707,392 		JBrowse link
G S100b S100 calcium binding protein B increases expression EXP Carbofuran results in increased expression of S100B mRNA; Carbofuran results in increased expression of S100B protein CTD PMID:28982980 PMID:30471306 NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,348...12,381,081 		JBrowse link
G Serpine1 serpin family E member 1 increases expression EXP Carbofuran results in increased expression of SERPINE1 mRNA CTD PMID:20211217 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Smad2 SMAD family member 2 increases expression
multiple interactions
increases phosphorylation 		EXP Carbofuran results in increased expression of SMAD2 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased phosphorylation of SMAD2 protein] 		CTD PMID:28982980 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388 		JBrowse link
G Smad3 SMAD family member 3 increases expression
multiple interactions
increases phosphorylation 		EXP Carbofuran results in increased expression of SMAD3 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased phosphorylation of SMAD3 protein] 		CTD PMID:28982980 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324 		JBrowse link
G Smad7 SMAD family member 7 decreases expression EXP Carbofuran results in decreased expression of SMAD7 mRNA; Carbofuran results in decreased expression of SMAD7 protein CTD PMID:28982980 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:71,263,508...71,291,849 		JBrowse link
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 decreases expression EXP Carbofuran results in decreased expression of SMURF2 mRNA CTD PMID:28982980 NCBI chr10:92,261,516...92,362,185
Ensembl chr10:92,261,525...92,362,552 		JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression EXP Carbofuran results in decreased expression of SOX2 protein CTD PMID:22240977 NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP Carbofuran results in increased expression of SPP1 mRNA CTD PMID:20211217 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression EXP Carbofuran results in increased expression of STAT3 mRNA CTD PMID:22240977 PMID:28982980 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression EXP Carbofuran results in increased expression of TGFB1 mRNA; Carbofuran results in increased expression of TGFB1 protein CTD PMID:28982980 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Carbofuran results in increased expression of TGFB2 mRNA CTD PMID:20211217 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856 		JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 increases expression EXP Carbofuran results in increased expression of TIAM1 mRNA CTD PMID:20211217 NCBI chr11:42,517,527...42,866,280
Ensembl chr11:42,517,528...42,646,075 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Carbofuran results in increased expression of TIMP1 mRNA CTD PMID:20211217 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tnni3 troponin I3, cardiac type increases expression EXP Carbofuran results in increased expression of TNNI3 protein CTD PMID:19854236 NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:78,342,592...78,346,253 		JBrowse link
G Tnnt2 troponin T2, cardiac type increases expression EXP Carbofuran results in increased expression of TNNT2 protein CTD PMID:19854236 NCBI chr13:49,819,123...49,837,125
Ensembl chr13:49,822,304...49,837,125 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Carbofuran results in decreased stability of and results in increased degradation of and results in increased mutagenesis of TP53 gene CTD PMID:22445671 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tubb3 tubulin, beta 3 class III decreases expression EXP Carbofuran results in decreased expression of TUBB3 mRNA CTD PMID:28982980 NCBI chr19:68,365,687...68,374,741
Ensembl chr19:68,365,587...68,374,740 		JBrowse link
G Tubb6 tubulin, beta 6 class V increases expression EXP Carbofuran results in increased expression of TUBB6 mRNA CTD PMID:20211217 NCBI chr18:63,213,287...63,222,926
Ensembl chr18:63,213,279...63,224,303 		JBrowse link
G Uck2 uridine-cytidine kinase 2 increases expression EXP Carbofuran results in increased expression of UCK2 mRNA CTD PMID:20211217 NCBI chr13:81,913,732...81,971,036
Ensembl chr13:81,916,818...81,971,091 		JBrowse link
G Vcan versican increases expression
decreases expression 		EXP Carbofuran results in increased expression of VCAN mRNA
Carbofuran results in decreased expression of VCAN mRNA 		CTD PMID:20211217 PMID:30471306 NCBI chr 2:22,497,035...22,595,955
Ensembl chr 2:22,497,035...22,595,955 		JBrowse link
carbosulfan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP
ISO 		carbosulfan results in decreased activity of ACHE protein
carbosulfan metabolite results in decreased activity of ACHE protein; carbosulfan results in decreased activity of ACHE protein 		CTD PMID:3710030 PMID:33844597 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
increases metabolic processing
increases expression 		ISO carbosulfan results in increased activity of CYP2B6 protein
CYP2B6 protein results in increased metabolism of carbosulfan
carbosulfan results in increased expression of CYP2B6 mRNA 		CTD PMID:20307514 PMID:22310298 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity
increases activity
increases expression 		ISO CYP3A4 protein results in increased metabolism of and results in increased activity of carbosulfan; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of carbosulfan]
carbosulfan results in decreased activity of CYP3A4 protein
carbosulfan results in increased activity of CYP3A4 protein
carbosulfan results in increased expression of CYP3A4 mRNA 		CTD PMID:20307514 PMID:22310298 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO CYP3A5 protein results in increased metabolism of carbosulfan CTD PMID:20307514 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression ISO carbosulfan results in increased expression of NR1I3 mRNA CTD PMID:22310298 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370 		JBrowse link
ethiofencarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO croneton inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein] CTD PMID:26647222 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843 		JBrowse link
formetanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP formetanate results in decreased activity of ACHE protein CTD PMID:19934164 PMID:21251949 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP [Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein CTD PMID:22649187 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression ISO formetanate results in decreased expression of HSPA1A protein CTD PMID:16271832 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO formetanate results in increased expression of HSPA5 protein CTD PMID:16271832 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO formetanate results in decreased expression of HSPA8 protein CTD PMID:16271832 NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO formetanate results in increased activity of NFE2L2 protein CTD PMID:20143881 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Park7 Parkinsonism associated deglycase decreases activity ISO formetanate results in decreased activity of PARK7 protein CTD PMID:36842454 NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825 		JBrowse link
furathiocarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
increases activity 		ISO deltanit results in increased expression of CYP2B6 mRNA
deltanit results in increased activity of CYP2B6 protein 		CTD PMID:22310298 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity
increases expression 		ISO deltanit results in increased activity of CYP3A4 protein
deltanit results in increased expression of CYP3A4 mRNA 		CTD PMID:22310298 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression ISO deltanit results in increased expression of NR1I3 mRNA CTD PMID:22310298 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370 		JBrowse link
isoprocarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 affects activity ISO isoprocarb metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
metolcarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Thrb thyroid hormone receptor beta affects binding ISO metolcarb binds to THRB protein CTD PMID:28973306 NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680 		JBrowse link
oxamyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP
ISO 		oxamyl results in decreased activity of ACHE protein CTD PMID:19934164 PMID:21251949 PMID:27132127 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP [Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein CTD PMID:22649187 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO oxamyl inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Park7 Parkinsonism associated deglycase decreases activity ISO oxamyl results in decreased activity of PARK7 protein CTD PMID:36842454 NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO oxamyl inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO
EXP 		[Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to oxamyl; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to oxamyl
[Calcium results in increased activity of PON1 protein] which affects the susceptibility to oxamyl; [Egtazic Acid results in decreased activity of PON1 protein] which affects the susceptibility to oxamyl 		CTD PMID:27132127 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO oxamyl metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
pirimicarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO pirimicarb results in decreased activity of ACHE protein CTD PMID:33037899 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity ISO pirimicarb results in increased activity of CYP19A1 protein CTD PMID:11884232 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO pirimicarb results in decreased expression of ESR1 mRNA CTD PMID:15261991 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression ISO pirimicarb results in decreased expression of HSPA1A protein CTD PMID:16271832 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO pirimicarb results in increased expression of HSPA5 protein CTD PMID:16271832 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO pirimicarb results in decreased expression of HSPA8 protein CTD PMID:16271832 NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372 		JBrowse link
G Hspb2 heat shock protein family B (small) member 2 decreases expression ISO pirimicarb results in decreased expression of HSPB2 protein CTD PMID:16271832 NCBI chr 8:59,989,640...59,991,215
Ensembl chr 8:59,976,623...59,990,901 		JBrowse link
G Lep leptin multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Lepr leptin receptor multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in decreased expression of LEPR mRNA CTD PMID:29321614 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Nmb neuromedin B multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in decreased expression of NMB mRNA CTD PMID:29321614 NCBI chr 1:144,278,678...144,290,523
Ensembl chr 1:144,278,453...144,281,422 		JBrowse link
G Nmbr neuromedin B receptor multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of NMBR mRNA CTD PMID:29321614 NCBI chr 1:10,942,476...10,966,174
Ensembl chr 1:10,954,916...10,965,555 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of NPY1R mRNA CTD PMID:29321614 NCBI chr16:27,804,416...27,814,070
Ensembl chr16:27,804,416...27,813,387 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO pirimicarb metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
propoxur term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity 		ISO
EXP 		Obidoxime Chloride promotes the reaction [Propoxur results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [Propoxur results in decreased activity of ACHE protein] CTD PMID:14644616 PMID:19934164 PMID:21251949 PMID:23962483 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP [Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein CTD PMID:22649187 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760 		JBrowse link
G Cat catalase multiple interactions
decreases activity 		EXP [Propoxur co-treated with Permethrin] results in increased activity of CAT protein; Melatonin inhibits the reaction [Propoxur results in decreased activity of CAT protein] CTD PMID:24733834 PMID:28456543 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP Propoxur results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:188,501,209...188,535,105 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP Propoxur results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:64,313,669...64,333,248 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Propoxur inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Propoxur inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
thiodicarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO
EXP 		thiodicarb results in decreased activity of ACHE protein CTD PMID:21251949 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      application 20572
        pesticide 18454
          insecticide 17179
            carbamate insecticide 164
              XMC 0
              alanycarb 0
              aldicarb 32
              aminocarb 1
              bendiocarb 6
              benfuracarb 5
              butocarboxim 0
              butoxycarboxim 0
              carbanolate 0
              carbaryl 65
              carbofuran 81
              carbosulfan 5
              ethiofencarb 1
              formetanate 7
              furathiocarb 3
              isoprocarb 1
              metolcarb 1
              oxamyl 7
              pirimicarb 13
              propoxur 7
              thiodicarb 1
              thiofanox 0
              trimethacarb 0
              xylylcarb 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        inhibitor 19071
          enzyme inhibitor 18710
            EC 3.* (hydrolase) inhibitor 17214
              EC 3.1.* (ester hydrolase) inhibitor 14877
                EC 3.1.1.* (carboxylic ester hydrolase) inhibitor 10677
                  EC 3.1.1.7 (acetylcholinesterase) inhibitor 10392
                    carbamate insecticide 164
                      XMC 0
                      alanycarb 0
                      aldicarb 32
                      aminocarb 1
                      bendiocarb 6
                      benfuracarb 5
                      butocarboxim 0
                      butoxycarboxim 0
                      carbanolate 0
                      carbaryl 65
                      carbofuran 81
                      carbosulfan 5
                      ethiofencarb 1
                      formetanate 7
                      furathiocarb 3
                      isoprocarb 1
                      metolcarb 1
                      oxamyl 7
                      pirimicarb 13
                      propoxur 7
                      thiodicarb 1
                      thiofanox 0
                      trimethacarb 0
                      xylylcarb 0
paths to the root