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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:muconic acid
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Accession:CHEBI:38407 term browser browse the term
Definition:A hexadienedioic acid with unsaturation at positions 2 and 4.
Synonyms:exact_synonym: hexa-2,4-dienedioic acid
 related_synonym: 1,3-butadiene-1,4-dicarboxylic acid;   2,4-hexadienedioic acid;   Formula=C6H6O4;   InChI=1S/C6H6O4/c7-5(8)3-1-2-4-6(9)10/h1-4H,(H,7,8)(H,9,10);   InChIKey=TXXHDPDFNKHHGW-UHFFFAOYSA-N;   SMILES=[H]C(=CC=C([H])C(O)=O)C(O)=O;   butadiene-1,4-dicarboxylic acid
 alt_id: CHEBI:25424;   CHEBI:36156
 xref: Beilstein:1722248;   Beilstein:1756239;   CAS:505-70-4
 xref_mesh: MESH:C005939
 xref: PMID:23079953;   PMID:23164574;   PMID:24657371;   PMID:24751381
 cyclic_relationship: is_conjugate_acid_of CHEBI:36504


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muconic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of muconic acid CTD PMID:15051535 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ephx1 epoxide hydrolase 1 multiple interactions ISO [EPHX1 protein affects the metabolism of Benzene] which affects the abundance of muconic acid CTD PMID:10511268 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions ISO [GSTM1 protein affects the metabolism of Benzene] which affects the abundance of muconic acid CTD PMID:10511268 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects abundance ISO GSTT1 affects the abundance of muconic acid CTD PMID:10780264 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 affects abundance ISO NQO1 polymorphism affects the abundance of muconic acid CTD PMID:12798093 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            xenobiotic metabolite 14041
              human xenobiotic metabolite 13294
                muconic acid 5
                  (2E,4Z)-2-hydroxymuconic acid 0
                  (2Z,4E)-2-hydroxymuconic acid 0
                  2-aminomuconic acid 0
                  3-carboxymethylmuconic acid 0
                  3-sulfomuconic acid 0
                  5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one 0
                  chloromuconic acid + 0
                  cis,cis-muconic acid + 0
                  cis,trans-muconic acid + 0
                  trans,trans-muconic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      dicarboxylic acids and O-substituted derivatives 10271
                                        dicarboxylic acid 10264
                                          polyunsaturated dicarboxylic acid 57
                                            hexadienedioic acid 5
                                              muconic acid 5
                                                (2E,4Z)-2-hydroxymuconic acid 0
                                                (2Z,4E)-2-hydroxymuconic acid 0
                                                2-aminomuconic acid 0
                                                3-carboxymethylmuconic acid 0
                                                3-sulfomuconic acid 0
                                                5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one 0
                                                chloromuconic acid + 0
                                                cis,cis-muconic acid + 0
                                                cis,trans-muconic acid + 0
                                                trans,trans-muconic acid + 0
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