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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hex-4-enoic acid
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Accession:CHEBI:38355 term browser browse the term
Definition:A hexenoic acid with the double bond at position 4.
Synonyms:related_synonym: 4-hexenoic acid;   4-hexenoic acids;   Formula=C6H10O2;   InChI=1S/C6H10O2/c1-2-3-4-5-6(7)8/h2-3H,4-5H2,1H3,(H,7,8);   InChIKey=NIDHFQDUBOVBKZ-UHFFFAOYSA-N;   SMILES=[H]C(C)=CCCC(O)=O;   gamma-hexenoic acid;   gamma-hexenoic acids;   hex-4-enoic acids
 xref: Beilstein:1720995;   LIPID_MAPS_instance:LMFA01030010


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mycophenolate mofetil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NPHS1 NPHS1 adhesion molecule, nephrin multiple interactions ISO Mycophenolate mofetil inhibits reaction [streptozotocin decreases expression of Nphs1 mRNA and protein in kidney] RGD PMID:17624267 RGD:38596322 NCBI chr19:35,862,915...35,869,287
Ensembl chr19:35,825,964...35,869,287
JBrowse link
mycophenolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCF1 ATP binding cassette subfamily F member 1 increases expression ISO Mycophenolic Acid results in increased expression of ABCF1 mRNA CTD PMID:19818335 NCBI chr 6:30,571,442...30,591,522
Ensembl chr 6:30,571,393...30,597,179
JBrowse link
G ADM adrenomedullin multiple interactions ISO Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased expression of ADM protein] CTD PMID:15063164 NCBI chr11:10,305,073...10,307,397
Ensembl chr11:10,305,073...10,307,397
JBrowse link
G AGT angiotensinogen decreases expression ISO Mycophenolic Acid results in decreased expression of AGT protein alternative form CTD PMID:15213268 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
JBrowse link
G AIF1 allograft inflammatory factor 1 decreases expression
multiple interactions
ISO Mycophenolic Acid results in decreased expression of AIF1 mRNA
[Quercetin co-treated with Mycophenolic Acid] results in decreased expression of AIF1 mRNA
CTD PMID:10688038 NCBI chr 6:31,615,212...31,617,015
Ensembl chr 6:31,615,217...31,617,021
JBrowse link
G AIMP1 aminoacyl tRNA synthetase complex interacting multifunctional protein 1 increases expression ISO Mycophenolic Acid results in increased expression of AIMP1 mRNA CTD PMID:19818335 NCBI chr 4:106,315,544...106,349,456
Ensembl chr 4:106,315,544...106,349,456
JBrowse link
G AKT1 AKT serine/threonine kinase 1 increases expression EXP Mycophenolic Acid results in increased expression of AKT1 protein CTD PMID:21396949 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALB albumin affects binding EXP Mycophenolic Acid binds to ALB protein CTD PMID:26892221 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G AR androgen receptor multiple interactions EXP Mycophenolic Acid binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ATF1 activating transcription factor 1 multiple interactions EXP Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of ATF1 protein] CTD PMID:20302854 NCBI chr12:50,763,682...50,821,162
Ensembl chr12:50,763,710...50,821,162
JBrowse link
G BAK1 BCL2 antagonist/killer 1 increases expression EXP Mycophenolic Acid results in increased expression of BAK1 protein CTD PMID:16505121 NCBI chr 6:33,572,552...33,580,296
Ensembl chr 6:33,572,547...33,580,293
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP [Mycophenolic Acid co-treated with Hypoxanthine] results in increased expression of BAX protein CTD PMID:21396949 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP [Mycophenolic Acid co-treated with Hypoxanthine] results in decreased expression of BCL2 protein; Mycophenolic Acid inhibits the reaction [BCL2 protein results in decreased susceptibility to Dexamethasone] CTD PMID:16505121 PMID:21396949 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP1 caspase 1 increases expression ISO Mycophenolic Acid results in increased expression of CASP1 mRNA CTD PMID:19818335 NCBI chr11:105,025,443...105,035,591
Ensembl chr11:105,025,443...105,035,250
JBrowse link
G CASP3 caspase 3 increases activity
multiple interactions
EXP Mycophenolic Acid results in increased activity of CASP3 protein
[Mycophenolic Acid co-treated with Hypoxanthine] results in increased activity of CASP3 protein
CTD PMID:16059982 PMID:16505121 PMID:21396949 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CCL15 C-C motif chemokine ligand 15 decreases expression
increases expression
ISO Mycophenolic Acid results in decreased expression of CCL6 mRNA
Mycophenolic Acid results in increased expression of CCL6 mRNA
CTD PMID:19818335 NCBI chr17:35,997,582...36,001,553
Ensembl chr17:35,996,440...36,001,553
JBrowse link
G CCL19 C-C motif chemokine ligand 19 increases expression ISO Mycophenolic Acid results in increased expression of CCL19 mRNA CTD PMID:19818335 NCBI chr 9:34,689,570...34,691,276
Ensembl chr 9:34,689,570...34,691,276
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of CCL2 protein] CTD PMID:17624267 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCL20 C-C motif chemokine ligand 20 decreases expression
increases expression
ISO Mycophenolic Acid results in decreased expression of CCL20 mRNA
Mycophenolic Acid results in increased expression of CCL20 mRNA
CTD PMID:19818335 NCBI chr 2:227,813,842...227,817,556
Ensembl chr 2:227,805,739...227,817,564
JBrowse link
G CCL22 C-C motif chemokine ligand 22 increases expression ISO Mycophenolic Acid results in increased expression of CCL22 mRNA CTD PMID:19818335 NCBI chr16:57,358,783...57,366,189
Ensembl chr16:57,358,783...57,366,189
JBrowse link
G CCL25 C-C motif chemokine ligand 25 increases expression ISO Mycophenolic Acid results in increased expression of CCL25 mRNA CTD PMID:19818335 NCBI chr19:8,052,341...8,062,650
Ensembl chr19:8,052,318...8,062,660
JBrowse link
G CCL4 C-C motif chemokine ligand 4 decreases expression ISO Mycophenolic Acid results in decreased expression of CCL4 mRNA CTD PMID:19818335 NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621
JBrowse link
G CCL5 C-C motif chemokine ligand 5 multiple interactions
decreases expression
ISO [Quercetin co-treated with Mycophenolic Acid] results in decreased expression of CCL5 mRNA
Mycophenolic Acid results in decreased expression of CCL5 mRNA
CTD PMID:10688038 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
JBrowse link
G CCL7 C-C motif chemokine ligand 7 decreases expression ISO Mycophenolic Acid results in decreased expression of CCL7 mRNA CTD PMID:19818335 NCBI chr17:34,270,221...34,272,242
Ensembl chr17:34,270,221...34,272,242
JBrowse link
G CCR10 C-C motif chemokine receptor 10 increases expression ISO Mycophenolic Acid results in increased expression of CCR10 mRNA CTD PMID:19818335 NCBI chr17:42,678,889...42,681,843
Ensembl chr17:42,678,889...42,683,917
JBrowse link
G CCR2 C-C motif chemokine receptor 2 increases expression ISO Mycophenolic Acid results in increased expression of CCR2 mRNA CTD PMID:19818335 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940
JBrowse link
G CCR3 C-C motif chemokine receptor 3 increases expression ISO Mycophenolic Acid results in increased expression of CCR3 mRNA CTD PMID:19818335 NCBI chr 3:46,210,699...46,266,706
Ensembl chr 3:46,130,890...46,266,706
JBrowse link
G CCR6 C-C motif chemokine receptor 6 increases expression ISO Mycophenolic Acid results in increased expression of CCR6 mRNA CTD PMID:19818335 NCBI chr 6:167,111,795...167,139,141
Ensembl chr 6:167,111,807...167,139,696
JBrowse link
G CCR9 C-C motif chemokine receptor 9 increases expression ISO Mycophenolic Acid results in increased expression of CCR9 mRNA CTD PMID:19818335 NCBI chr 3:45,886,064...45,903,174
Ensembl chr 3:45,886,509...45,903,174
JBrowse link
G CD40LG CD40 ligand increases expression ISO Mycophenolic Acid results in increased expression of CD40LG mRNA CTD PMID:19818335 NCBI chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B multiple interactions EXP Mycophenolic Acid inhibits the reaction [IL2 protein results in decreased expression of CDKN1B protein] CTD PMID:12193749 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions EXP Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CREB1 protein] CTD PMID:20302854 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 increases expression ISO Mycophenolic Acid results in increased expression of CX3CL1 mRNA CTD PMID:19818335 NCBI chr16:57,372,490...57,385,044
Ensembl chr16:57,372,477...57,385,044
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 decreases expression
increases expression
ISO Mycophenolic Acid results in decreased expression of CXCL1 mRNA
Mycophenolic Acid results in increased expression of CXCL1 mRNA
CTD PMID:19818335 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 increases expression ISO Mycophenolic Acid results in increased expression of CXCL12 mRNA CTD PMID:19818335 NCBI chr10:44,292,088...44,385,097
Ensembl chr10:44,370,165...44,386,493
JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 increases expression ISO Mycophenolic Acid results in increased expression of CXCL2 protein CTD PMID:19818335 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression
decreases expression
increases secretion
multiple interactions
ISO
EXP
Mycophenolic Acid results in increased expression of CXCL15 mRNA; Mycophenolic Acid results in increased expression of CXCL5 mRNA
Mycophenolic Acid results in decreased expression of CXCL5 mRNA
Mycophenolic Acid results in increased secretion of CXCL8 protein
Mycophenolic Acid results in increased expression of CXCL8 mRNA
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased secretion of CXCL8 protein]
CTD PMID:19818335 PMID:20302854 PMID:29408666 PMID:29594315 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 increases expression ISO Mycophenolic Acid results in increased expression of CXCR2 mRNA CTD PMID:19818335 NCBI chr 2:218,125,294...218,137,253
Ensembl chr 2:218,125,289...218,137,251
JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 increases expression ISO Mycophenolic Acid results in increased expression of CXCR3 mRNA CTD PMID:19818335 NCBI chr  X:71,615,913...71,618,515
Ensembl chr  X:71,615,916...71,618,511
JBrowse link
G CXCR5 C-X-C motif chemokine receptor 5 increases expression ISO Mycophenolic Acid results in increased expression of CXCR5 mRNA CTD PMID:19818335 NCBI chr11:118,883,892...118,897,787
Ensembl chr11:118,883,892...118,897,787
JBrowse link
G CYCS cytochrome c, somatic increases secretion EXP Mycophenolic Acid results in increased secretion of CYCS protein CTD PMID:16505121 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression
multiple interactions
EXP Mycophenolic Acid results in increased expression of CYP1A1 mRNA
Mycophenolic Acid affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Esomeprazole results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:25929522 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions EXP Mycophenolic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA] CTD PMID:25929522 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 increases methylation EXP CYP2C8 protein results in increased methylation of Mycophenolic Acid CTD PMID:15570183 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases methylation
multiple interactions
EXP CYP3A4 protein results in increased methylation of Mycophenolic Acid
[Mycophenolic Acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:15570183 PMID:25455453 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 increases methylation EXP CYP3A5 protein results in increased methylation of Mycophenolic Acid CTD PMID:15570183 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,998
JBrowse link
G DES desmin multiple interactions ISO Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of DES protein] CTD PMID:17624267 NCBI chr 2:219,418,377...219,426,734
Ensembl chr 2:219,418,377...219,426,735
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP Mycophenolic Acid binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 multiple interactions EXP Mycophenolic Acid binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Mycophenolic Acid results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G GCNA germ cell nuclear acidic peptidase decreases expression EXP Mycophenolic Acid results in decreased expression of GCNA mRNA CTD PMID:24356939 NCBI chr  X:71,578,041...71,613,583
Ensembl chr  X:71,578,437...71,613,583
JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions EXP Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GSK3B protein] CTD PMID:20302854 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,321...120,094,994
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 decreases expression EXP Mycophenolic Acid results in decreased expression of HSPA5 mRNA CTD PMID:24356939 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
G IFNG interferon gamma decreases expression
multiple interactions
ISO
EXP
Mycophenolic Acid results in decreased expression of IFNG mRNA
[Mycophenolic Acid co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA
CTD PMID:11562063 PMID:29594315 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL10 interleukin 10 decreases expression ISO Mycophenolic Acid results in decreased expression of IL10 mRNA CTD PMID:11562063 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL10RA interleukin 10 receptor subunit alpha increases expression ISO Mycophenolic Acid results in increased expression of IL10RA mRNA CTD PMID:19818335 NCBI chr11:117,986,394...118,003,037
Ensembl chr11:117,986,370...118,003,037
JBrowse link
G IL10RB interleukin 10 receptor subunit beta increases expression ISO Mycophenolic Acid results in increased expression of IL10RB mRNA CTD PMID:19818335 NCBI chr21:33,266,367...33,297,221
Ensembl chr21:33,266,367...33,310,187
JBrowse link
G IL11 interleukin 11 increases expression ISO Mycophenolic Acid results in increased expression of IL11 mRNA CTD PMID:19818335 NCBI chr19:55,364,382...55,370,463
Ensembl chr19:55,364,382...55,370,463
JBrowse link
G IL12RB2 interleukin 12 receptor subunit beta 2 decreases expression ISO Mycophenolic Acid results in decreased expression of IL12RB2 mRNA CTD PMID:11562063 NCBI chr 1:67,307,351...67,398,724
Ensembl chr 1:67,307,364...67,398,724
JBrowse link
G IL13 interleukin 13 increases expression ISO Mycophenolic Acid results in increased expression of IL13 mRNA CTD PMID:19818335 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
JBrowse link
G IL15 interleukin 15 increases expression ISO Mycophenolic Acid results in increased expression of IL15 mRNA CTD PMID:19818335 NCBI chr 4:141,636,583...141,733,987
Ensembl chr 4:141,636,583...141,733,987
JBrowse link
G IL16 interleukin 16 increases expression ISO Mycophenolic Acid results in increased expression of IL16 mRNA CTD PMID:19818335 NCBI chr15:81,196,879...81,314,058
Ensembl chr15:81,159,575...81,314,058
JBrowse link
G IL18 interleukin 18 decreases expression ISO Mycophenolic Acid results in decreased expression of IL18 mRNA CTD PMID:19818335 NCBI chr11:112,143,251...112,164,104
Ensembl chr11:112,143,253...112,164,096
JBrowse link
G IL1R1 interleukin 1 receptor type 1 increases expression ISO Mycophenolic Acid results in increased expression of IL1R1 mRNA CTD PMID:19818335 NCBI chr 2:102,069,638...102,179,874
Ensembl chr 2:102,064,544...102,179,874
JBrowse link
G IL1R2 interleukin 1 receptor type 2 increases expression ISO Mycophenolic Acid results in increased expression of IL1R2 mRNA CTD PMID:19818335 NCBI chr 2:101,991,805...102,028,544
Ensembl chr 2:101,991,960...102,028,544
JBrowse link
G IL2 interleukin 2 multiple interactions
decreases expression
EXP
ISO
[Mycophenolic Acid co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA; Mycophenolic Acid inhibits the reaction [IL2 protein results in decreased expression of CDKN1B protein]
Mycophenolic Acid results in decreased expression of IL2 mRNA
CTD PMID:11562063 PMID:12193749 PMID:29594315 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL2RB interleukin 2 receptor subunit beta increases expression ISO Mycophenolic Acid results in increased expression of IL2RB mRNA CTD PMID:19818335 NCBI chr22:37,125,838...37,175,118
Ensembl chr22:37,125,843...37,175,054
JBrowse link
G IL2RG interleukin 2 receptor subunit gamma increases expression ISO Mycophenolic Acid results in increased expression of IL2RG mRNA CTD PMID:19818335 NCBI chr  X:71,107,404...71,111,577
Ensembl chr  X:71,107,404...71,112,108
JBrowse link
G IL3 interleukin 3 increases expression ISO Mycophenolic Acid results in increased expression of IL3 mRNA CTD PMID:19818335 NCBI chr 5:132,060,655...132,063,204
Ensembl chr 5:132,060,655...132,063,204
JBrowse link
G IL4 interleukin 4 decreases expression ISO Mycophenolic Acid results in decreased expression of IL4 mRNA CTD PMID:11562063 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL5RA interleukin 5 receptor subunit alpha increases expression ISO Mycophenolic Acid results in increased expression of IL5RA mRNA CTD PMID:19818335 NCBI chr 3:3,066,324...3,110,414
Ensembl chr 3:3,066,324...3,126,613
JBrowse link
G IL6 interleukin 6 increases expression EXP Mycophenolic Acid results in increased expression of IL6 protein CTD PMID:11981085 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G IL6R interleukin 6 receptor increases expression ISO Mycophenolic Acid results in increased expression of IL6RA mRNA CTD PMID:19818335 NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450
JBrowse link
G IL6ST interleukin 6 cytokine family signal transducer increases expression ISO Mycophenolic Acid results in increased expression of IL6ST mRNA CTD PMID:19818335 NCBI chr 5:55,935,095...55,994,963
Ensembl chr 5:55,935,095...55,995,022
JBrowse link
G IMPDH2 inosine monophosphate dehydrogenase 2 increases expression ISO Mycophenolic Acid results in increased expression of IMPDH2 mRNA CTD PMID:11145582 NCBI chr 3:49,024,325...49,029,750
Ensembl chr 3:49,024,325...49,029,447
JBrowse link
G ITGAM integrin subunit alpha M increases expression ISO Mycophenolic Acid results in increased expression of ITGAM mRNA CTD PMID:19818335 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
JBrowse link
G KLRK1 killer cell lectin like receptor K1 decreases expression EXP Mycophenolic Acid results in decreased expression of KLRK1 CTD PMID:20736080 NCBI chr12:10,372,353...10,390,041
Ensembl chr12:10,372,353...10,391,874
JBrowse link
G KRCC1 lysine rich coiled-coil 1 decreases expression EXP Mycophenolic Acid results in decreased expression of KRCC1 mRNA CTD PMID:24356939 NCBI chr 2:88,027,205...88,055,783
Ensembl chr 2:88,027,205...88,064,252
JBrowse link
G LRRC37A3 leucine rich repeat containing 37 member A3 decreases expression EXP Mycophenolic Acid results in decreased expression of LRRC37A3 mRNA CTD PMID:24356939 NCBI chr17:64,854,130...64,919,478
Ensembl chr17:64,854,130...64,919,480
JBrowse link
G LTA lymphotoxin alpha increases expression ISO Mycophenolic Acid results in increased expression of LTA mRNA CTD PMID:19818335 NCBI chr 6:31,560,550...31,574,324
Ensembl chr 6:31,572,054...31,574,324
JBrowse link
G LTB lymphotoxin beta increases expression ISO Mycophenolic Acid results in increased expression of LTB mRNA CTD PMID:19818335 NCBI chr 6:31,580,558...31,582,425
Ensembl chr 6:31,580,525...31,582,522
JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase multiple interactions EXP [Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of LYN protein CTD PMID:15604220 NCBI chr 8:55,876,041...56,014,169
Ensembl chr 8:55,879,835...56,014,169
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
decreases expression
EXP Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]
Mycophenolic Acid results in decreased expression of MAPK1 protein modified form
CTD PMID:20302854 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
decreases expression
EXP Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]
Mycophenolic Acid results in decreased expression of MAPK3 protein modified form
CTD PMID:20302854 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions
decreases expression
EXP
ISO
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]
Mycophenolic Acid results in decreased expression of MAPK8 protein modified form
CTD PMID:20302854 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions
decreases expression
EXP
ISO
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]
Mycophenolic Acid results in decreased expression of MAPK9 protein modified form
CTD PMID:20302854 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099
JBrowse link
G MAPT microtubule associated protein tau decreases expression EXP Mycophenolic Acid results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr17:45,894,538...46,028,334
Ensembl chr17:45,894,527...46,028,334
JBrowse link
G MIF macrophage migration inhibitory factor increases expression ISO Mycophenolic Acid results in increased expression of MIF mRNA CTD PMID:19818335 NCBI chr22:23,894,383...23,895,223
Ensembl chr22:23,894,383...23,895,227
JBrowse link
G NANOS1 nanos C2HC-type zinc finger 1 increases expression EXP Mycophenolic Acid results in increased expression of NANOS1 mRNA CTD PMID:24356939 NCBI chr10:119,029,714...119,033,730
Ensembl chr10:119,029,714...119,033,730
JBrowse link
G NCR1 natural cytotoxicity triggering receptor 1 decreases expression EXP Mycophenolic Acid results in decreased expression of NCR1 CTD PMID:20736080 NCBI chr19:54,906,063...54,938,211
Ensembl chr19:54,906,148...54,916,140
JBrowse link
G NCR2 natural cytotoxicity triggering receptor 2 decreases expression EXP Mycophenolic Acid results in decreased expression of NCR2 CTD PMID:20736080 NCBI chr 6:41,335,608...41,350,889
Ensembl chr 6:41,335,608...41,350,889
JBrowse link
G NCR3 natural cytotoxicity triggering receptor 3 decreases expression EXP Mycophenolic Acid results in decreased expression of NCR3 CTD PMID:20736080 NCBI chr 6:31,588,895...31,593,024
Ensembl chr 6:31,588,895...31,593,006
JBrowse link
G NPHS1 NPHS1 adhesion molecule, nephrin multiple interactions ISO Mycophenolic Acid inhibits the reaction [Streptozocin results in decreased expression of NPHS1 mRNA]; Mycophenolic Acid inhibits the reaction [Streptozocin results in decreased expression of NPHS1 protein] CTD PMID:17624267 NCBI chr19:35,862,915...35,869,287
Ensembl chr19:35,825,964...35,869,287
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity
multiple interactions
EXP Mycophenolic Acid results in increased activity of NR1I2 protein
[Mycophenolic Acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:25455453 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487
JBrowse link
G PDCD4 programmed cell death 4 increases expression EXP Mycophenolic Acid results in increased expression of PDCD4 mRNA CTD PMID:24356939 NCBI chr10:110,871,928...110,900,006
Ensembl chr10:110,871,795...110,900,006
JBrowse link
G PGR progesterone receptor multiple interactions EXP Mycophenolic Acid binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr11:101,029,624...101,130,681
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G PRKCA protein kinase C alpha increases expression EXP Mycophenolic Acid results in increased expression of PRKCA protein CTD PMID:21396949 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743
JBrowse link
G RAC1 Rac family small GTPase 1 multiple interactions ISO Mycophenolic Acid inhibits the reaction [RAC1 protein results in increased abundance of Reactive Oxygen Species] CTD PMID:17950325 NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit decreases expression
multiple interactions
ISO
EXP
Mycophenolic Acid results in decreased expression of RELA protein modified form
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RELA protein]
CTD PMID:20302854 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RGS2 regulator of G protein signaling 2 increases expression EXP Mycophenolic Acid results in increased expression of RGS2 mRNA CTD PMID:24356939 NCBI chr 1:192,809,039...192,812,275
Ensembl chr 1:192,809,039...192,812,275
JBrowse link
G RPS6 ribosomal protein S6 multiple interactions EXP [Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of RPS6 protein CTD PMID:15604220 NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Mycophenolic Acid inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G SLC7A11 solute carrier family 7 member 11 decreases expression EXP Mycophenolic Acid results in decreased expression of SLC7A11 mRNA CTD PMID:24356939 NCBI chr 4:138,164,097...138,242,349
Ensembl chr 4:138,164,097...138,242,349
JBrowse link
G SPP1 secreted phosphoprotein 1 increases expression ISO Mycophenolic Acid results in increased expression of SPP1 mRNA CTD PMID:19818335 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532
JBrowse link
G STAT5A signal transducer and activator of transcription 5A multiple interactions EXP [Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of STAT5A protein CTD PMID:15604220 NCBI chr17:42,287,547...42,311,943
Ensembl chr17:42,287,547...42,311,943
JBrowse link
G TGFB1 transforming growth factor beta 1 decreases expression ISO Mycophenolic Acid results in decreased expression of TGFB1 mRNA CTD PMID:11562063 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G THRA thyroid hormone receptor alpha multiple interactions EXP Mycophenolic Acid binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867
JBrowse link
G TNF tumor necrosis factor decreases expression
multiple interactions
increases expression
ISO Mycophenolic Acid results in decreased expression of TNF mRNA
Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased expression of TNF mRNA]; Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased secretion of TNF protein]
Mycophenolic Acid results in increased expression of TNF mRNA; Mycophenolic Acid results in increased expression of TNF protein
CTD PMID:11562063 PMID:11912253 PMID:19818335 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A increases expression ISO Mycophenolic Acid results in increased expression of TNFRSF1A mRNA CTD PMID:19818335 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114
JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B increases expression ISO Mycophenolic Acid results in increased expression of TNFRSF1B mRNA CTD PMID:19818335 NCBI chr 1:12,166,948...12,209,222
Ensembl chr 1:12,166,991...12,209,228
JBrowse link
G TSPOAP1 TSPO associated protein 1 decreases expression EXP Mycophenolic Acid results in decreased expression of TSPOAP1 mRNA CTD PMID:24356939 NCBI chr17:58,301,231...58,328,795
Ensembl chr17:58,301,228...58,328,795
JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
multiple interactions
affects metabolic processing
EXP UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid
4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]; [4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]] which results in increased abundance of Mycophenolic Acid; [UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide
UGT1A9 gene SNP affects the metabolism of Mycophenolic Acid
CTD PMID:18498916 PMID:18816295 PMID:31742356 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300
JBrowse link
G ZBED8 zinc finger BED-type containing 8 increases expression EXP Mycophenolic Acid results in increased expression of ZBED8 mRNA CTD PMID:24356939 NCBI chr 5:160,393,148...160,400,054
Ensembl chr 5:160,393,148...160,400,054
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24845
    chemical entity 24815
      atom 24805
        nonmetal atom 24544
          carbon atom 24436
            organic molecular entity 24436
              lipid 20094
                fatty acid 18335
                  medium-chain fatty acid 3655
                    hexenoic acid 112
                      hex-4-enoic acid 112
                        2-oxohex-4-enoic acid + 0
                        cis-hex-4-enoic acid + 0
                        mycophenolic acid + 112
                        trans-hex-4-enoic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24845
    subatomic particle 24805
      composite particle 24805
        hadron 24805
          baryon 24805
            nucleon 24805
              atomic nucleus 24805
                atom 24805
                  main group element atom 24674
                    p-block element atom 24674
                      carbon group element atom 24472
                        carbon atom 24436
                          organic molecular entity 24436
                            organic group 22892
                              organic divalent group 22872
                                organodiyl group 22872
                                  carbonyl group 22866
                                    carbonyl compound 22866
                                      carboxylic acid 21941
                                        monocarboxylic acid 20871
                                          fatty acid 18335
                                            unsaturated fatty acid 971
                                              monounsaturated fatty acid 459
                                                hexenoic acid 112
                                                  hex-4-enoic acid 112
                                                    2-oxohex-4-enoic acid + 0
                                                    cis-hex-4-enoic acid + 0
                                                    mycophenolic acid + 112
                                                    trans-hex-4-enoic acid + 0
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