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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:usnic acid
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Accession:CHEBI:38319 term browser browse the term
Definition:A member of the class of dibenzofurans that is dibenzo[b,d]furan-1(9bH)-one substituted by acetyl groups at positions 2 and 6, hydroxy groups at positions 3 and 7 and methyl groups at positions 8 and 9b.
Synonyms:exact_synonym: 2,6-diacetyl-3,7,9-trihydroxy-8,9b-dimethyldibenzo[b,d]furan-1(9bH)-one
 related_synonym: Formula=C18H16O7;   InChI=1S/C18H16O7/c1-6-14(22)12(8(3)20)16-13(15(6)23)18(4)10(25-16)5-9(21)11(7(2)19)17(18)24/h5,21-23H,1-4H3;   InChIKey=WEYVVCKOOFYHRW-UHFFFAOYSA-N;   SMILES=CC(=O)C1=C(O)C=C2Oc3c(c(O)c(C)c(O)c3C(C)=O)C2(C)C1=O;   Usninsaeure;   usnein;   usniacin;   usninic acid
 xref: Beilstein:346490;   Beilstein:96699;   CAS:125-46-2
 xref_mesh: MESH:C073339
 xref: PMID:11034349;   PMID:18887895;   PMID:19034791;   PMID:19349177;   PMID:20379653;   PMID:24770718;   Reaxys:96699;   Wikipedia:Usnic_acid


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usnic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO usnic acid results in decreased phosphorylation of and results in decreased expression of AKT1 protein CTD PMID:25078063 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO 2-aminoethoxydiphenyl borate inhibits the reaction [usnic acid results in increased expression of ATF4 protein] CTD PMID:25870318 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atm ATM serine/threonine kinase increases phosphorylation
multiple interactions
ISO usnic acid results in increased phosphorylation of ATM protein
Acetylcysteine inhibits the reaction [usnic acid results in increased phosphorylation of ATM protein]
CTD PMID:31715134 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
ISO usnic acid results in decreased expression of BAX protein
usnic acid results in increased expression of BAX protein
CTD PMID:22285236, PMID:31715134 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO usnic acid results in decreased expression of BCL2 protein CTD PMID:22285236, PMID:25078063, PMID:31715134 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO 3-methyladenine promotes the reaction [usnic acid results in increased activity of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [usnic acid results in increased activity of CASP3 protein]; Chloroquine promotes the reaction [usnic acid results in increased activity of CASP3 protein]; pyrazolanthrone promotes the reaction [usnic acid results in increased activity of CASP3 protein] CTD PMID:22285236, PMID:25078063, PMID:25870318 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 increases cleavage ISO usnic acid results in increased cleavage of CASP4 protein CTD PMID:25870318 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO 3-methyladenine promotes the reaction [usnic acid results in increased activity of CASP7 protein]; 4-phenylbutyric acid inhibits the reaction [usnic acid results in increased activity of CASP7 protein]; Chloroquine promotes the reaction [usnic acid results in increased activity of CASP7 protein]; pyrazolanthrone promotes the reaction [usnic acid results in increased activity of CASP7 protein] CTD PMID:25078063, PMID:25870318 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Cat catalase multiple interactions EXP usnic acid inhibits the reaction [Indomethacin results in increased activity of CAT protein] CTD PMID:16169175 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 multiple interactions
increases expression
ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of CCL21 mRNA
usnic acid results in increased expression of CCL21 mRNA
CTD PMID:21953288, PMID:22777745 NCBI chr 5:58,197,678...58,198,782
Ensembl chr 5:58,197,680...58,198,782
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of CCL4 mRNA CTD PMID:22777745 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccnc cyclin C multiple interactions
increases expression
ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CCNC mRNA
usnic acid results in increased expression of CCNC mRNA
CTD PMID:21953288, PMID:22777745 NCBI chr 5:35,865,598...35,883,732
Ensembl chr 5:35,865,605...35,883,706
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO usnic acid results in decreased expression of CCND1 protein CTD PMID:27369375 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO usnic acid results in decreased expression of CCND3 protein CTD PMID:27369375 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO usnic acid results in decreased expression of CDK2 protein CTD PMID:27369375 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO usnic acid results in decreased expression of CDK4 protein CTD PMID:27369375 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO usnic acid results in decreased expression of CDK6 protein CTD PMID:27369375 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO usnic acid results in increased expression of CHEK1 protein modified form CTD PMID:27369375 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 increases expression
multiple interactions
ISO usnic acid results in increased expression of CHEK2 protein; usnic acid results in increased expression of CHEK2 protein modified form
Acetylcysteine inhibits the reaction [usnic acid results in increased expression of CHEK2 protein]
CTD PMID:27369375, PMID:31715134 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Cryab crystallin, alpha B multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CRYAB mRNA CTD PMID:22777745 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
decreases expression
ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CSF2 mRNA
usnic acid results in decreased expression of CSF2 mRNA
CTD PMID:21953288, PMID:22777745 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CXCL10 mRNA CTD PMID:22777745 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO usnic acid results in decreased expression of CYP1A1 mRNA CTD PMID:21953288 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases expression
ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CYP2E1 mRNA
usnic acid results in decreased expression of CYP2E1 mRNA
CTD PMID:21953288, PMID:22777745 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CYP7A1 mRNA CTD PMID:22777745 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Ddb1 damage-specific DNA binding protein 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of DDB1 mRNA CTD PMID:22777745 NCBI chr 1:226,657,561...226,683,356
Ensembl chr 1:226,657,561...226,683,347
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO 2-aminoethoxydiphenyl borate inhibits the reaction [usnic acid results in increased expression of DDIT3 protein]
usnic acid results in increased expression of DDIT3 mRNA; usnic acid results in increased expression of DDIT3 protein
CTD PMID:25870318 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO usnic acid results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:25078063 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of ERCC1 mRNA CTD PMID:22777745 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198
JBrowse link
G Faslg Fas ligand multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of FASLG mRNA CTD PMID:22777745 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of FMO1 mRNA CTD PMID:22777745 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO NFE2L2 protein promotes the reaction [usnic acid results in increased expression of GCLC protein]
usnic acid results in increased expression of GCLC mRNA; usnic acid results in increased expression of GCLC protein
CTD PMID:27369375 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of GPX1 mRNA CTD PMID:22777745 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases expression
ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of GSR mRNA
usnic acid results in increased expression of GSR protein
CTD PMID:22777745, PMID:27369375 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression ISO usnic acid results in increased expression of GSTA1 protein CTD PMID:27369375 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions
ISO usnic acid results in increased expression of H2AX protein modified form
NFE2L2 protein inhibits the reaction [usnic acid results in increased expression of H2AX protein modified form]
CTD PMID:27369375 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of HSP90AB1 mRNA CTD PMID:22777745 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of HSPA1A mRNA CTD PMID:22777745 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of HSPA2 mRNA CTD PMID:22777745 NCBI chr 6:99,433,575...99,436,288
Ensembl chr 6:99,433,550...99,436,289
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of HSPA5 mRNA CTD PMID:22777745 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of HSPH1 mRNA CTD PMID:22777745 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Il18 interleukin 18 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA CTD PMID:22777745 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of IL1A mRNA CTD PMID:22777745 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of IL1B mRNA CTD PMID:22777745 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of IL6 mRNA CTD PMID:22777745 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lta lymphotoxin alpha multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of LTA mRNA CTD PMID:22777745 NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO usnic acid results in increased phosphorylation of MAPK1 protein CTD PMID:25078063 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO usnic acid results in increased phosphorylation of MAPK3 protein CTD PMID:25078063 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
decreases expression
ISO 3-methyladenine promotes the reaction [usnic acid results in decreased expression of MCL1 protein]; Chloroquine promotes the reaction [usnic acid results in decreased expression of MCL1 protein]; pyrazolanthrone promotes the reaction [usnic acid results in decreased expression of MCL1 protein] CTD PMID:25078063 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mpo myeloperoxidase multiple interactions EXP usnic acid inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:16169175 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO usnic acid results in decreased phosphorylation of and results in decreased expression of MTOR protein CTD PMID:25078063 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO NFE2L2 protein inhibits the reaction [usnic acid results in increased expression of H2AX protein modified form]; NFE2L2 protein promotes the reaction [usnic acid results in increased expression of GCLC protein]; usnic acid results in increased expression of and affects the localization of NFE2L2 protein CTD PMID:27369375 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of NOS2 mRNA
usnic acid inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]
CTD PMID:16169175, PMID:22777745 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO usnic acid results in increased expression of NQO1 protein CTD PMID:27369375 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 increases expression
multiple interactions
ISO
EXP
usnic acid results in increased expression of ORAI1 protein
2-aminoethoxydiphenyl borate inhibits the reaction [usnic acid results in increased expression of ORAI1 protein]
CTD PMID:25870318 NCBI chr12:38,981,903...38,995,570
Ensembl chr12:38,981,927...38,995,570
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO usnic acid results in increased cleavage of PARP1 protein CTD PMID:31715134 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases phosphorylation ISO usnic acid results in decreased phosphorylation of PDK1 protein CTD PMID:25078063 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of POR mRNA CTD PMID:22777745 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit increases expression
multiple interactions
ISO usnic acid results in increased expression of PRKDC protein
Acetylcysteine inhibits the reaction [usnic acid results in increased expression of PRKDC protein]
CTD PMID:31715134 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of PTGS1 mRNA CTD PMID:22777745 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Rad50 RAD50 double strand break repair protein multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of RAD50 mRNA CTD PMID:22777745 NCBI chr10:39,002,130...39,054,042
Ensembl chr10:39,001,498...39,054,142
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO usnic acid results in decreased phosphorylation of RPS6KB1 protein CTD PMID:25078063 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of SERPINE1 mRNA CTD PMID:22777745 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sqstm1 sequestosome 1 increases degradation ISO usnic acid results in increased degradation of SQSTM1 protein CTD PMID:25078063 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Stim1 stromal interaction molecule 1 increases expression ISO
EXP
usnic acid results in increased expression of STIM1 protein CTD PMID:25870318 NCBI chr 1:167,373,894...167,533,412
Ensembl chr 1:167,373,678...167,533,420
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of TNF mRNA CTD PMID:22777745 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 decreases expression
multiple interactions
increases expression
ISO usnic acid results in decreased expression of TP53 protein
Acetylcysteine inhibits the reaction [usnic acid results in increased expression of TP53 protein]
CTD PMID:22285236, PMID:31715134 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 multiple interactions
increases expression
ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of UGT1A4 mRNA
usnic acid results in increased expression of UGT1A4 mRNA
CTD PMID:21953288, PMID:22777745 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Xbp1 X-box binding protein 1 increases splicing ISO usnic acid results in increased splicing of XBP1 mRNA CTD PMID:25870318 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of XRCC1 mRNA CTD PMID:22777745 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        pesticide 16430
          acaricide 9730
            usnic acid 70
              (+)-usnic acid 0
              (-)-usnic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      ketone 16173
                                        methyl ketone 733
                                          usnic acid 70
                                            (+)-usnic acid 0
                                            (-)-usnic acid 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.