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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor
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Accession:CHEBI:38317 term browser browse the term
Definition:An EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 atoms of oxygen) inhibitor that interferes with the activity of 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27).
Synonyms:related_synonym: 4-hydroxyphenylpyruvate dioxygenase inhibitor;   4-hydroxyphenylpyruvate dioxygenase inhibitors;   4-hydroxyphenylpyruvate hydroxylase inhibitor;   4-hydroxyphenylpyruvate hydroxylase inhibitors;   4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating) inhibitor;   4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating) inhibitors;   4-hydroxyphenylpyruvic acid dioxygenase inhibitor;   4-hydroxyphenylpyruvic acid dioxygenase inhibitors;   EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitors;   EC 1.13.11.27 inhibitor;   EC 1.13.11.27 inhibitors;   HPPD inhibitor;   HPPD inhibitors;   p-hydroxyphenylpyruvate dioxygenase inhibitor;   p-hydroxyphenylpyruvate dioxygenase inhibitors;   p-hydroxyphenylpyruvate hydroxylase inhibitor;   p-hydroxyphenylpyruvate hydroxylase inhibitors;   p-hydroxyphenylpyruvate oxidase inhibitor;   p-hydroxyphenylpyruvate oxidase inhibitors;   p-hydroxyphenylpyruvic acid hydroxylase inhibitor;   p-hydroxyphenylpyruvic acid hydroxylase inhibitors;   p-hydroxyphenylpyruvic hydroxylase inhibitor;   p-hydroxyphenylpyruvic hydroxylase inhibitors;   p-hydroxyphenylpyruvic oxidase inhibitor;   p-hydroxyphenylpyruvic oxidase inhibitors
 alt_id: CHEBI:50380


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mesotrione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrc4c leucine rich repeat containing 4C multiple interactions ISO [Herbicides results in increased abundance of mesotrione] which affects the methylation of LRRC4C gene CTD PMID:34516295 NCBI chr 2:96,148,514...97,466,871
Ensembl chr 2:96,148,514...97,462,011 		JBrowse link
G Mfsd4b1 major facilitator superfamily domain containing 4B1 multiple interactions ISO [Herbicides results in increased abundance of mesotrione] which affects the methylation of MFSD4B gene CTD PMID:34516295 NCBI chr10:39,877,569...39,901,264
Ensembl chr10:39,877,571...39,901,264 		JBrowse link
G Ms4a4a membrane-spanning 4-domains, subfamily A, member 4A multiple interactions ISO [Herbicides results in increased abundance of mesotrione] which affects the methylation of MS4A4A gene CTD PMID:34516295 NCBI chr19:11,352,827...11,370,682
Ensembl chr19:11,352,887...11,370,154 		JBrowse link
G Myo1b myosin IB multiple interactions ISO [Herbicides results in increased abundance of mesotrione] which affects the methylation of MYO1B gene CTD PMID:34516295 NCBI chr 1:51,788,915...51,955,143
Ensembl chr 1:51,788,924...51,955,230 		JBrowse link
G Pik3r4 phosphoinositide-3-kinase regulatory subunit 4 multiple interactions ISO [Herbicides results in increased abundance of mesotrione] which affects the methylation of PIK3R4 gene CTD PMID:34516295 NCBI chr 9:105,520,156...105,564,854
Ensembl chr 9:105,520,177...105,564,856 		JBrowse link
G Ppp1r2 protein phosphatase 1, regulatory inhibitor subunit 2 multiple interactions ISO [Herbicides results in increased abundance of mesotrione] which affects the methylation of PPP1R2 gene CTD PMID:34516295 NCBI chr16:31,070,359...31,094,095
Ensembl chr16:31,070,355...31,094,095 		JBrowse link
G Schip1 schwannomin interacting protein 1 multiple interactions ISO [Herbicides results in increased abundance of mesotrione] which affects the methylation of SCHIP1 gene CTD PMID:34516295 NCBI chr 3:67,972,135...68,533,815
Ensembl chr 3:67,972,135...68,533,814 		JBrowse link
G Wdr43 WD repeat domain 43 multiple interactions ISO [Herbicides results in increased abundance of mesotrione] which affects the methylation of WDR43 gene CTD PMID:34516295 NCBI chr17:71,923,175...71,966,026
Ensembl chr17:71,922,890...71,966,026 		JBrowse link
nitisinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLC mRNA CTD PMID:12899938 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions EXP [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLM mRNA CTD PMID:12899938 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [nitisinone results in decreased activity of HPD protein] which results in decreased expression of HMOX1 mRNA CTD PMID:12899938 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hpd 4-hydroxyphenylpyruvic acid dioxygenase multiple interactions EXP [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLC mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLM mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of HMOX1 mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of NQO1 mRNA CTD PMID:12899938 NCBI chr 5:123,309,870...123,320,786
Ensembl chr 5:123,309,870...123,320,790 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions EXP [nitisinone results in decreased activity of HPD protein] which results in decreased expression of NQO1 mRNA CTD PMID:12899938 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
tembotrione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase increases activity ISO tembotrione results in increased activity of CAT protein CTD PMID:34627991 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      biological role 22178
        biochemical role 21449
          enzyme inhibitor 19910
            EC 1.* (oxidoreductase) inhibitor 18016
              EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor 6185
                EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor 6185
                  EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor 14
                    (-)-usnic acid 0
                    2-cyano-3-cyclopropyl-1-(2-mesyl-4-trifluoromethylphenyl)propan-1,3-dione 0
                    DAS645 0
                    DAS869 0
                    benquitrione 0
                    benzobicyclon 0
                    benzobicyclon hydrolysate 0
                    destosyl pyrazolate 0
                    isoxaflutole 0
                    mesotrione + 13
                    nitisinone 5
                    pyraquinate 0
                    pyrasulfotole 0
                    pyrazolynate 0
                    tefuryltrione 0
                    tembotrione 1
                    tolpyralate 0
                    topramezone 0
paths to the root