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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor
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Accession:CHEBI:38317 term browser browse the term
Definition:An EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 atoms of oxygen) inhibitor that interferes with the activity of 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27).
Synonyms:related_synonym: 4-hydroxyphenylpyruvate dioxygenase inhibitor;   4-hydroxyphenylpyruvate dioxygenase inhibitors;   4-hydroxyphenylpyruvate hydroxylase inhibitor;   4-hydroxyphenylpyruvate hydroxylase inhibitors;   4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating) inhibitor;   4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating) inhibitors;   4-hydroxyphenylpyruvic acid dioxygenase inhibitor;   4-hydroxyphenylpyruvic acid dioxygenase inhibitors;   EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitors;   EC 1.13.11.27 inhibitor;   EC 1.13.11.27 inhibitors;   HPPD inhibitor;   HPPD inhibitors;   p-hydroxyphenylpyruvate dioxygenase inhibitor;   p-hydroxyphenylpyruvate dioxygenase inhibitors;   p-hydroxyphenylpyruvate hydroxylase inhibitor;   p-hydroxyphenylpyruvate hydroxylase inhibitors;   p-hydroxyphenylpyruvate oxidase inhibitor;   p-hydroxyphenylpyruvate oxidase inhibitors;   p-hydroxyphenylpyruvic acid hydroxylase inhibitor;   p-hydroxyphenylpyruvic acid hydroxylase inhibitors;   p-hydroxyphenylpyruvic hydroxylase inhibitor;   p-hydroxyphenylpyruvic hydroxylase inhibitors;   p-hydroxyphenylpyruvic oxidase inhibitor;   p-hydroxyphenylpyruvic oxidase inhibitors
 alt_id: CHEBI:50380


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mesotrione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrc4c leucine rich repeat containing 4C multiple interactions ISO [Herbicides results in increased abundance of mesotrione] which affects the methylation of LRRC4C gene CTD PMID:34516295 NCBI chr 3:82,305,495...83,684,039
Ensembl chr 3:83,483,851...83,687,774 		JBrowse link
G Mfsd4b2 major facilitator superfamily domain containing 4B2 multiple interactions ISO [Herbicides results in increased abundance of mesotrione] which affects the methylation of MFSD4B gene CTD PMID:34516295 NCBI chr20:43,344,601...43,353,061
Ensembl chr20:43,344,601...43,353,061 		JBrowse link
G Ms4a4a membrane spanning 4-domains A4A multiple interactions ISO [Herbicides results in increased abundance of mesotrione] which affects the methylation of MS4A4A gene CTD PMID:34516295 NCBI chr 1:208,060,507...208,085,121
Ensembl chr 1:208,046,971...208,085,119 		JBrowse link
G Myo1b myosin Ib multiple interactions ISO [Herbicides results in increased abundance of mesotrione] which affects the methylation of MYO1B gene CTD PMID:34516295 NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798 		JBrowse link
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 multiple interactions ISO [Herbicides results in increased abundance of mesotrione] which affects the methylation of PIK3R4 gene CTD PMID:34516295 NCBI chr 8:106,267,908...106,316,585
Ensembl chr 8:106,267,954...106,316,584 		JBrowse link
G Ppp1r2 protein phosphatase 1, regulatory (inhibitor) subunit 2 multiple interactions ISO [Herbicides results in increased abundance of mesotrione] which affects the methylation of PPP1R2 gene CTD PMID:34516295 NCBI chr11:69,472,676...69,494,468
Ensembl chr11:69,472,555...69,494,463 		JBrowse link
G Schip1 schwannomin interacting protein 1 multiple interactions ISO [Herbicides results in increased abundance of mesotrione] which affects the methylation of SCHIP1 gene CTD PMID:34516295 NCBI chr 2:152,127,171...152,888,587
Ensembl chr 2:152,126,953...152,888,585 		JBrowse link
G Wdr43 WD repeat domain 43 multiple interactions ISO [Herbicides results in increased abundance of mesotrione] which affects the methylation of WDR43 gene CTD PMID:34516295 NCBI chr 6:23,845,499...23,884,846
Ensembl chr 6:23,845,499...23,884,846 		JBrowse link
nitisinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLC mRNA CTD PMID:12899938 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLM mRNA CTD PMID:12899938 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [nitisinone results in decreased activity of HPD protein] which results in decreased expression of HMOX1 mRNA CTD PMID:12899938 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hpd 4-hydroxyphenylpyruvate dioxygenase multiple interactions ISO [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLC mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLM mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of HMOX1 mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of NQO1 mRNA CTD PMID:12899938 NCBI chr12:33,381,397...33,392,750
Ensembl chr12:33,381,231...33,392,766 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [nitisinone results in decreased activity of HPD protein] which results in decreased expression of NQO1 mRNA CTD PMID:12899938 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
tembotrione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase increases activity EXP tembotrione results in increased activity of CAT protein CTD PMID:34627991 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19908
    role 19883
      biological role 19881
        biochemical role 19571
          enzyme inhibitor 18738
            EC 1.* (oxidoreductase) inhibitor 17462
              EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor 5693
                EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor 5693
                  EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor 14
                    (-)-usnic acid 0
                    2-cyano-3-cyclopropyl-1-(2-mesyl-4-trifluoromethylphenyl)propan-1,3-dione 0
                    DAS645 0
                    DAS869 0
                    benzobicyclon 0
                    benzobicyclon hydrolysate 0
                    destosyl pyrazolate 0
                    isoxaflutole 0
                    mesotrione + 13
                    nitisinone 5
                    pyrasulfotole 0
                    pyrazolynate 0
                    tefuryltrione 0
                    tembotrione 1
                    tolpyralate 0
                    topramezone 0
paths to the root