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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor
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Accession:CHEBI:38317 term browser browse the term
Definition:An EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 atoms of oxygen) inhibitor that interferes with the activity of 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27).
Synonyms:related_synonym: 4-hydroxyphenylpyruvate dioxygenase inhibitor;   4-hydroxyphenylpyruvate dioxygenase inhibitors;   4-hydroxyphenylpyruvate hydroxylase inhibitor;   4-hydroxyphenylpyruvate hydroxylase inhibitors;   4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating) inhibitor;   4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating) inhibitors;   4-hydroxyphenylpyruvic acid dioxygenase inhibitor;   4-hydroxyphenylpyruvic acid dioxygenase inhibitors;   EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitors;   EC 1.13.11.27 inhibitor;   EC 1.13.11.27 inhibitors;   HPPD inhibitor;   HPPD inhibitors;   p-hydroxyphenylpyruvate dioxygenase inhibitor;   p-hydroxyphenylpyruvate dioxygenase inhibitors;   p-hydroxyphenylpyruvate hydroxylase inhibitor;   p-hydroxyphenylpyruvate hydroxylase inhibitors;   p-hydroxyphenylpyruvate oxidase inhibitor;   p-hydroxyphenylpyruvate oxidase inhibitors;   p-hydroxyphenylpyruvic acid hydroxylase inhibitor;   p-hydroxyphenylpyruvic acid hydroxylase inhibitors;   p-hydroxyphenylpyruvic hydroxylase inhibitor;   p-hydroxyphenylpyruvic hydroxylase inhibitors;   p-hydroxyphenylpyruvic oxidase inhibitor;   p-hydroxyphenylpyruvic oxidase inhibitors
 alt_id: CHEBI:50380


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Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLC mRNA CTD PMID:12899938 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLM mRNA CTD PMID:12899938 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [nitisinone results in decreased activity of HPD protein] which results in decreased expression of HMOX1 mRNA CTD PMID:12899938 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hpd 4-hydroxyphenylpyruvate dioxygenase multiple interactions ISO [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLC mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLM mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of HMOX1 mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of NQO1 mRNA CTD PMID:12899938 NCBI chr12:38,828,606...38,839,956
Ensembl chr12:38,828,444...38,839,969
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [nitisinone results in decreased activity of HPD protein] which results in decreased expression of NQO1 mRNA CTD PMID:12899938 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link

Term paths to the root
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  CHEBI ontology 19771
    role 19716
      biological role 19716
        biochemical role 19304
          enzyme inhibitor 18227
            EC 1.* (oxidoreductase) inhibitor 16647
              EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor 4792
                EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor 4792
                  EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor 5
                    (-)-usnic acid 0
                    2-cyano-3-cyclopropyl-1-(2-mesyl-4-trifluoromethylphenyl)propan-1,3-dione 0
                    DAS645 0
                    DAS869 0
                    benzobicyclon 0
                    benzobicyclon hydrolysate 0
                    destosyl pyrazolate 0
                    isoxaflutole 0
                    mesotrione + 5
                    nitisinone 5
                    pyrasulfotole 0
                    pyrazolynate 0
                    tefuryltrione 0
                    tembotrione 0
                    tolpyralate 0
                    topramezone 0
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