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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein]; Biotin inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; Biotin inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein] |
CTD |
PMID:32383521 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
App |
amyloid beta precursor protein |
multiple interactions |
EXP |
[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; Biotin inhibits the reaction [Aluminum Chloride results in increased expression of APP protein] |
CTD |
PMID:32383521 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Ccna2 |
cyclin A2 |
increases expression |
ISO |
Biotin results in increased expression of CCNA2 mRNA |
CTD |
PMID:34699867 |
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NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnd3 |
cyclin D3 |
increases expression |
ISO |
Biotin results in increased expression of CCND3 mRNA |
CTD |
PMID:34699867 |
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NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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G |
Ccne1 |
cyclin E1 |
increases expression |
ISO |
Biotin results in increased expression of CCNE1 mRNA |
CTD |
PMID:34699867 |
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NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Cdk2 |
cyclin dependent kinase 2 |
increases expression |
ISO |
Biotin results in increased expression of CDK2 mRNA |
CTD |
PMID:34699867 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk4 |
cyclin-dependent kinase 4 |
increases expression |
ISO |
Biotin results in increased expression of CDK4 mRNA |
CTD |
PMID:34699867 |
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NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
decreases expression |
ISO |
Biotin results in decreased expression of CDKN1A mRNA |
CTD |
PMID:34699867 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cidea |
cell death-inducing DFFA-like effector a |
multiple interactions |
ISO |
[acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of CIDEA mRNA |
CTD |
PMID:34323617 |
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NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
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G |
Cidec |
cell death-inducing DFFA-like effector c |
multiple interactions |
ISO |
[acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA |
CTD |
PMID:34323617 |
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NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173
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G |
Cxcl11 |
C-X-C motif chemokine ligand 11 |
decreases expression |
ISO |
Biotin results in decreased expression of CXCL11 mRNA |
CTD |
PMID:15219929 |
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NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions increases expression |
ISO |
Biotin results in increased expression of and results in increased activity of CYP1B1 protein Biotin results in increased expression of CYP1B1 mRNA |
CTD |
PMID:15219929 PMID:15333708 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
ISO |
Biotin inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein] |
CTD |
PMID:9143349 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
E2f1 |
E2F transcription factor 1 |
increases expression |
ISO |
Biotin results in increased expression of E2F1 mRNA |
CTD |
PMID:34699867 |
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NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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G |
Hba-a2 |
hemoglobin alpha, adult chain 2 |
multiple interactions |
ISO |
[Chromium co-treated with Biotin] results in decreased expression of HBA1 protein modified form; [chromium tripicolinate co-treated with Biotin] results in decreased expression of HBA1 protein modified form |
CTD |
PMID:17684468 |
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NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392
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G |
Herc4 |
HECT and RLD domain containing E3 ubiquitin protein ligase 4 |
increases expression |
ISO |
Biotin results in increased expression of HERC4 mRNA |
CTD |
PMID:15219929 |
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NCBI chr20:25,329,972...25,404,657
Ensembl chr20:25,330,280...25,404,657
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G |
Hira |
histone cell cycle regulator |
decreases expression |
ISO |
Biotin results in decreased expression of HIRA mRNA |
CTD |
PMID:15219929 |
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NCBI chr11:82,024,469...82,133,212
Ensembl chr11:82,024,469...82,133,529
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G |
Ighg1 |
immunoglobulin heavy constant gamma 1 |
increases expression |
ISO |
Biotin results in increased expression of IGHG1 mRNA |
CTD |
PMID:15219929 |
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Ensembl chr 6:132,389,370...132,393,397
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; Biotin inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein] |
CTD |
PMID:32383521 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein]; Biotin inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein] |
CTD |
PMID:32383521 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Ins1 |
insulin 1 |
multiple interactions |
ISO |
[acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of CIDEA mRNA; [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein; [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA |
CTD |
PMID:34323617 |
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NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Irs1 |
insulin receptor substrate 1 |
multiple interactions |
EXP |
[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein]; Biotin inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein] |
CTD |
PMID:32383521 |
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NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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G |
Lamp1 |
lysosomal-associated membrane protein 1 |
decreases expression |
ISO |
Biotin results in decreased expression of LAMP1 mRNA |
CTD |
PMID:15219929 |
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NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases expression |
ISO |
Biotin results in increased expression of MAPK1 protein |
CTD |
PMID:34699867 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
ISO |
Biotin results in increased expression of PPARGC1A mRNA |
CTD |
PMID:23056435 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Sdha |
succinate dehydrogenase complex flavoprotein subunit A |
multiple interactions |
ISO |
[acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein |
CTD |
PMID:34323617 |
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NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535
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G |
Sele |
selectin E |
affects binding |
ISO |
[Acetylglucosamine analog binds to Biotin] which binds to SELE protein |
CTD |
PMID:12191509 |
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NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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G |
Sell |
selectin L |
affects binding |
EXP |
[Acetylglucosamine analog binds to Biotin] which binds to SELL protein |
CTD |
PMID:12191509 |
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NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
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G |
Selp |
selectin P |
affects binding |
ISO |
[Acetylglucosamine analog binds to Biotin] which binds to SELP protein |
CTD |
PMID:12191509 |
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NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
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G |
Slc5a6 |
solute carrier family 5 member 6 |
affects expression increases transport increases uptake multiple interactions |
ISO EXP |
Biotin affects the expression of SLC5A6 mRNA; Biotin affects the expression of SLC5A6 protein SLC5A6 protein results in increased transport of Biotin; SLC5A6 results in increased transport of Biotin SLC5A6 results in increased uptake of Biotin 2,4-Dinitrophenol inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; 4-Chloromercuribenzenesulfonate inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Azides inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; calmidazolium inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; chelerythrine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Gramicidin inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Iodoacetates inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Ouabain inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Probenecid inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Sodium affects the reaction [SLC5A6 results in increased transport of Biotin]; Sodium promotes the reaction [SLC5A6 protein results in increased transport of Biotin]; Staurosporine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Tetradecanoylphorbol Acetate promotes the reaction [SLC5A6 protein results in increased transport of Biotin]; Trifluoperazine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] Sodium affects the reaction [SLC5A6 results in increased transport of Biotin]; Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Biotin] |
CTD |
PMID:9516450 PMID:10329687 PMID:10516089 PMID:12646417 PMID:15561972 |
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NCBI chr 6:25,319,187...25,331,713
Ensembl chr 6:25,320,442...25,331,712
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G |
Sp1 |
Sp1 transcription factor |
increases expression |
ISO |
Biotin results in increased expression of SP1 mRNA |
CTD |
PMID:34699867 |
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NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
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G |
Sp3 |
Sp3 transcription factor |
increases expression |
ISO |
Biotin results in increased expression of SP3 mRNA |
CTD |
PMID:34699867 |
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NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
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G |
Tf |
transferrin |
multiple interactions |
ISO |
[acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of CIDEA mRNA; [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein; [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA |
CTD |
PMID:34323617 |
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NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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G |
Tmprss15 |
transmembrane serine protease 15 |
increases expression |
ISO |
Biotin results in increased expression of TMPRSS15 mRNA |
CTD |
PMID:15219929 |
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NCBI chr11:17,677,741...17,802,255
Ensembl chr11:17,677,741...17,802,255
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]; Biotin inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein] |
CTD |
PMID:32383521 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tpr |
translocated promoter region, nuclear basket protein |
increases expression |
ISO |
Biotin results in increased expression of TPR mRNA |
CTD |
PMID:15219929 |
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NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
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