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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:thiabicycloalkane
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Accession:CHEBI:38297 term browser browse the term
Synonyms:related_synonym: thiabicycloalkanes

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biotin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein]; Biotin inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; Biotin inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein] CTD PMID:32383521 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; Biotin inhibits the reaction [Aluminum Chloride results in increased expression of APP protein] CTD PMID:32383521 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 decreases expression ISO Biotin results in decreased expression of CXCL11 mRNA CTD PMID:15219929 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression		 ISO Biotin results in increased expression of and results in increased activity of CYP1B1 protein
Biotin results in increased expression of CYP1B1 mRNA		 CTD PMID:15219929 PMID:15333708 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Biotin inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein] CTD PMID:9143349 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 multiple interactions ISO [Chromium co-treated with Biotin] results in decreased expression of HBA1 protein modified form; [chromium tripicolinate co-treated with Biotin] results in decreased expression of HBA1 protein modified form CTD PMID:17684468 NCBI chr10:15,589,364...15,590,207
Ensembl chr10:15,589,364...15,590,220 		JBrowse link
G Herc4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 increases expression ISO Biotin results in increased expression of HERC4 mRNA CTD PMID:15219929 NCBI chr20:26,755,948...26,831,267
Ensembl chr20:26,755,911...26,830,931 		JBrowse link
G Hira histone cell cycle regulator decreases expression ISO Biotin results in decreased expression of HIRA mRNA CTD PMID:15219929 NCBI chr11:86,168,196...86,276,430
Ensembl chr11:86,168,196...86,276,430 		JBrowse link
G Ighg1 immunoglobulin heavy constant gamma 1 increases expression ISO Biotin results in increased expression of IGHG1 mRNA CTD PMID:15219929 NCBI chr 6:139,140,572...139,784,388
Ensembl chr 6:139,140,679...139,142,218 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; Biotin inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein] CTD PMID:32383521 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein]; Biotin inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein] CTD PMID:32383521 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein]; Biotin inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein] CTD PMID:32383521 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 decreases expression ISO Biotin results in decreased expression of LAMP1 mRNA CTD PMID:15219929 NCBI chr16:81,689,576...81,714,341
Ensembl chr16:81,689,335...81,714,419 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Biotin results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Sele selectin E affects binding ISO [Acetylglucosamine analog binds to Biotin] which binds to SELE protein CTD PMID:12191509 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341 		JBrowse link
G Sell selectin L affects binding EXP [Acetylglucosamine analog binds to Biotin] which binds to SELL protein CTD PMID:12191509 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631 		JBrowse link
G Selp selectin P affects binding ISO [Acetylglucosamine analog binds to Biotin] which binds to SELP protein CTD PMID:12191509 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628 		JBrowse link
G Slc5a6 solute carrier family 5 member 6 affects expression
increases transport
multiple interactions
increases uptake		 ISO
EXP		 Biotin affects the expression of SLC5A6 mRNA; Biotin affects the expression of SLC5A6 protein
SLC5A6 results in increased transport of Biotin
Sodium affects the reaction [SLC5A6 results in increased transport of Biotin]; Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Biotin]
2,4-Dinitrophenol inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; 4-Chloromercuribenzenesulfonate inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Azides inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; calmidazolium inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; chelerythrine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Gramicidin inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Iodoacetates inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Ouabain inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Probenecid inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Sodium affects the reaction [SLC5A6 results in increased transport of Biotin]; Sodium promotes the reaction [SLC5A6 protein results in increased transport of Biotin]; Staurosporine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Tetradecanoylphorbol Acetate promotes the reaction [SLC5A6 protein results in increased transport of Biotin]; Trifluoperazine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]
SLC5A6 results in increased uptake of Biotin
SLC5A6 protein results in increased transport of Biotin; SLC5A6 results in increased transport of Biotin		 CTD PMID:9516450 PMID:10329687 PMID:10516089 PMID:12646417 PMID:15561972 NCBI chr 6:26,685,823...26,697,110
Ensembl chr 6:26,686,033...26,697,116 		JBrowse link
G Tmprss15 transmembrane serine protease 15 increases expression ISO Biotin results in increased expression of TMPRSS15 mRNA CTD PMID:15219929 NCBI chr11:17,561,591...17,684,903
Ensembl chr11:17,561,596...17,684,903 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]; Biotin inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein] CTD PMID:32383521 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tpr translocated promoter region, nuclear basket protein increases expression ISO Biotin results in increased expression of TPR mRNA CTD PMID:15219929 NCBI chr13:67,611,685...67,672,833
Ensembl chr13:67,611,708...67,672,827 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    chemical entity 19875
      atom 19873
        nonmetal atom 19751
          sulfur atom 16315
            sulfur molecular entity 16315
              organosulfur compound 15247
                organosulfur heterocyclic compound 5853
                  thiabicycloalkane 21
                    ATTO 425-7 0
                    ATTO 465-7 0
                    ATTO 495-7 0
                    ATTO 520-7 0
                    ATTO 610-7 0
                    ATTO 635-7 0
                    biocytin + 0
                    biotins + 21
                    tetranorbiotin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic molecule 19586
                              organic cyclic compound 19395
                                organic heterocyclic compound 18511
                                  organic heteropolycyclic compound 17900
                                    organic heterobicyclic compound 16826
                                      thiabicycloalkane 21
                                        ATTO 425-7 0
                                        ATTO 465-7 0
                                        ATTO 495-7 0
                                        ATTO 520-7 0
                                        ATTO 610-7 0
                                        ATTO 635-7 0
                                        biocytin + 0
                                        biotins + 21
                                        tetranorbiotin 0
paths to the root