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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyclopentapyrrole
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Accession:CHEBI:38296 term browser browse the term
Synonyms:related_synonym: cyclopentapyrroles



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ramipril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity ISO Ramipril results in decreased activity of ACE protein CTD PMID:3034026 PMID:10543928 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression
decreases expression
ISO candesartan promotes the reaction [Ramipril results in increased expression of ADIPOQ]; Ramipril promotes the reaction [candesartan results in increased expression of ADIPOQ]
Ramipril results in decreased expression of ADIPOQ
CTD PMID:17483542 PMID:19059660 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression EXP Ramipril affects the expression of BAX protein CTD PMID:10728395 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression EXP Ramipril affects the expression of BCL2 protein CTD PMID:10728395 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions EXP Ramipril inhibits the reaction [Tacrolimus results in decreased expression of BMP7 protein] CTD PMID:17703430 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [Simvastatin co-treated with Ramipril] results in decreased expression of CCL2 protein CTD PMID:15184351 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased expression of CCN2 protein CTD PMID:31062909 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ces1d carboxylesterase 1D increases hydrolysis ISO CES1 protein results in increased hydrolysis of Ramipril CTD PMID:25445008 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP Ramipril results in decreased expression of COL1A1 mRNA CTD PMID:11851355 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
decreases expression
ISO Ramipril inhibits the reaction [Cyclosporine results in increased expression of CYBA mRNA]; Ramipril inhibits the reaction [Tacrolimus results in increased expression of CYBA mRNA]
Ramipril results in decreased expression of CYBA mRNA
CTD PMID:12352326 PMID:16891913 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cybb cytochrome b-245 beta chain decreases expression ISO Ramipril results in decreased expression of CYBB mRNA CTD PMID:16891913 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Foxo3 forkhead box O3 multiple interactions EXP [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased phosphorylation of FOXO3 protein CTD PMID:31062909 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Kng2 kininogen 2 decreases degradation EXP Ramipril results in decreased degradation of KNG1 protein CTD PMID:2535056 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Lep leptin multiple interactions
decreases expression
ISO candesartan promotes the reaction [Ramipril results in increased expression of LEP]; Ramipril promotes the reaction [candesartan results in increased expression of LEP]
Ramipril results in decreased expression of LEP
CTD PMID:17483542 PMID:19059660 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP [Resveratrol co-treated with Ramipril] inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]; Ramipril inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein] CTD PMID:31062909 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression EXP Ramipril results in decreased expression of MMP2 mRNA CTD PMID:11851355 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Myh7 myosin heavy chain 7 decreases expression EXP Ramipril results in decreased expression of MYH7 mRNA CTD PMID:15667801 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP [Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of NOS1 protein; Metoprolol inhibits the reaction [[Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of NOS1 protein]; Metoprolol inhibits the reaction [Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA]]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA] CTD PMID:11832429 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO NOS3 protein affects the reaction [Ramipril results in increased abundance of Cyclic GMP] CTD PMID:16891913 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nppb natriuretic peptide B decreases expression EXP Ramipril results in decreased expression of NPPB mRNA CTD PMID:15667801 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions
decreases expression
ISO Ramipril inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PDGFA mRNA]
Ramipril results in decreased expression of PDGFA mRNA
CTD PMID:10352363 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions
decreases expression
ISO Ramipril inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PDGFB mRNA]
Ramipril results in decreased expression of PDGFB mRNA
CTD PMID:10352363 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of PTGS2 protein; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of PTGS2 mRNA] CTD PMID:11832429 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ren renin increases activity
increases expression
multiple interactions
ISO
EXP
Ramipril results in increased activity of REN protein
Ramipril results in increased expression of REN protein
Ramipril inhibits the reaction [Isoproterenol results in increased expression of REN protein]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased activity of REN protein]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of REN mRNA]
Ramipril results in increased expression of REN mRNA
CTD PMID:1327051 PMID:9179393 PMID:9539862 PMID:11832429 PMID:14504926 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP [Resveratrol co-treated with Ramipril] inhibits the reaction [Streptozocin results in increased expression of RHOA protein]; Ramipril inhibits the reaction [Streptozocin results in increased expression of RHOA protein] CTD PMID:31062909 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 multiple interactions EXP [Resveratrol co-treated with Ramipril] inhibits the reaction [Streptozocin results in increased expression of ROCK2 protein]; Ramipril inhibits the reaction [Streptozocin results in increased expression of ROCK2 protein] CTD PMID:31062909 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased expression of SIRT1 protein CTD PMID:31062909 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO Ramipril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP Ramipril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased phosphorylation of SMAD2 protein CTD PMID:31062909 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
decreases activity
ISO
EXP
Ramipril inhibits the reaction [Cyclosporine results in increased expression of TGFB1 mRNA]; Ramipril inhibits the reaction [Tacrolimus results in increased expression of TGFB1 mRNA]
Ramipril results in decreased expression of TGFB1 mRNA
[Streptozocin co-treated with Ramipril] results in increased expression of TGFB1 protein; [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased expression of TGFB1 protein; Ramipril inhibits the reaction [Tacrolimus results in increased expression of TGFB1 protein]
Ramipril results in decreased activity of TGFB1 protein
CTD PMID:12352326 PMID:12631109 PMID:15667801 PMID:17703430 PMID:20551625 More... NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 multiple interactions EXP [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased expression of TGFBR3 protein CTD PMID:31062909 NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341
JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 increases expression EXP Ramipril results in increased expression of TIMP4 mRNA CTD PMID:11851355 NCBI chr 4:148,306,021...148,312,558
Ensembl chr 4:148,304,490...148,312,558
JBrowse link
ramiprilat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdkrb2 bradykinin receptor B2 increases response to substance ISO BDKRB2 results in increased susceptibility to ramiprilat CTD PMID:10523327 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G Kng2 kininogen 2 decreases degradation EXP ramiprilat results in decreased degradation of KNG1 protein CTD PMID:2535056 NCBI chr11:77,913,876...77,936,247 JBrowse link
telaprevir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO telaprevir inhibits the reaction [CYP3A4 protein results in increased metabolism of Simvastatin] CTD PMID:24927617 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19823
    chemical entity 19823
      atom 19821
        nonmetal atom 19709
          nitrogen atom 18778
            nitrogen molecular entity 18778
              organonitrogen compound 18555
                organonitrogen heterocyclic compound 17670
                  cyclopentapyrrole 35
                    ramipril 33
                    ramiprilat 2
                    telaprevir 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      p-block molecular entity 19720
                        carbon group molecular entity 19643
                          organic molecular entity 19633
                            organic molecule 19572
                              organic cyclic compound 19366
                                organic heterocyclic compound 18604
                                  organic heteropolycyclic compound 18067
                                    organic heterobicyclic compound 16872
                                      cyclopentapyrrole 35
                                        ramipril 33
                                        ramiprilat 2
                                        telaprevir 1
paths to the root