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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carvone
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Accession:CHEBI:38265 term browser browse the term
Definition:A p-menthane monoterpenoid that consists of cyclohex-2-enone having methyl and isopropenyl substituents at positions 2 and 5, respectively.
Synonyms:exact_synonym: 2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one;   p-mentha-1(6),8-dien-2-one
 related_synonym: 1-carvone;   2-methyl-5-(1-methyl-1-ethenyl)-2-cyclohexen-1-one;   2-methyl-5-(1-methylethenyl)-2-cyclohexen-1-one;   2-methyl-5-(prop-1-en-2-yl)cyclohex-2-enone;   2-methyl-5-isopropenyl-2-cyclohexenone;   5-isopropenyl-2-methylcyclohex-2-en-1-one;   Carvon;   Formula=C10H14O;   InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4,9H,1,5-6H2,2-3H3;   InChIKey=ULDHMXUKGWMISQ-UHFFFAOYSA-N;   Karvon;   SMILES=CC(=C)C1CC=C(C)C(=O)C1;   carvol;   p-mentha-6,8-dien-2-one
 xref: Beilstein:1364206;   CAS:99-49-0;   Gmelin:102300
 xref_mesh: MESH:C006923
 xref: MetaCyc:Carvones;   PMID:16638680;   PMID:19876560;   PMID:20233552;   PMID:21428701;   Reaxys:1364206;   Wikipedia:Carvone



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carvone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO [carvone co-treated with limonene] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; carvone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:29191726 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO carvone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
carvone results in increased expression of CYP1A1 mRNA
CTD PMID:29191726 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO carvone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO carvone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO carvone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Gna15 G protein subunit alpha 15 multiple interactions
increases response to substance
ISO [GNA15 protein results in increased susceptibility to carvone] which results in increased activity of OLFR50 protein CTD PMID:9875846 NCBI chr 7:8,184,632...8,205,508
Ensembl chr 7:8,184,861...8,205,508
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 increases expression
increases secretion
ISO carvone results in increased expression of GNRH1 mRNA
carvone results in increased secretion of GNRH1 protein
CTD PMID:10566683 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581
JBrowse link
G Por cytochrome p450 oxidoreductase increases response to substance ISO POR protein results in increased susceptibility to carvone analog CTD PMID:21376747 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Rhoa ras homolog family member A increases expression
multiple interactions
ISO carvone results in increased expression of RHOA protein
Mevalonic Acid affects the reaction [carvone results in increased expression of RHOA protein]
CTD PMID:12671036 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rhob ras homolog family member B multiple interactions
increases expression
ISO Mevalonic Acid affects the reaction [carvone results in increased expression of RHOB protein] CTD PMID:12671036 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19763
      biological role 19763
        aetiopathogenetic role 19042
          allergen 17274
            carvone 10
              (+)-carvone 0
              (-)-carvone + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    main group molecular entity 19710
                      s-block molecular entity 19492
                        hydrogen molecular entity 19484
                          hydrides 18850
                            organic hydride 18362
                              organic fundamental parent 18362
                                hydrocarbon 18074
                                  terpene 12727
                                    terpenoid 12295
                                      monoterpenoid 1212
                                        p-menthane monoterpenoid 437
                                          carvones 10
                                            carvone 10
                                              (+)-carvone 0
                                              (-)-carvone + 0
paths to the root