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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isophthalonitrile
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Accession:CHEBI:38218 term browser browse the term
Definition:A nitrile that has formula C8H4N2.
Synonyms:exact_synonym: benzene-1,3-dicarbonitrile
 related_synonym: 1,3-Benzenedicarbonitrile;   1,3-Dicyanobenzene;   3-Cyanobenzonitrile;   Formula=C8H4N2;   IPN;   InChI=1S/C8H4N2/c9-5-7-2-1-3-8(4-7)6-10/h1-4H;   InChIKey=LAQPNDIUHRHNCV-UHFFFAOYSA-N;   Isophthalodinitrile;   SMILES=N#Cc1cccc(c1)C#N;   m-Dicyanobenzene
 xref: Beilstein:2038364;   CAS:626-17-5


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Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acly ATP citrate lyase decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of ACLY mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of ACLY mRNA
CTD PMID:33246813 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Acot1 acyl-CoA thioesterase 1 decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of ACOT1 mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of ACOT1 mRNA
CTD PMID:33246813 NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions
decreases expression
ISO [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of ACOX1 mRNA
tetrachloroisophthalonitrile results in decreased expression of ACOX1 mRNA
CTD PMID:33246813 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of ACTA2 mRNA CTD PMID:32289622 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions EXP tetrachloroisophthalonitrile binds to and results in increased activity of AHR protein CTD PMID:14636698 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Angpt4 angiopoietin 4 multiple interactions ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of ANGPT4 mRNA CTD PMID:33246813 NCBI chr 3:140,420,389...140,454,213
Ensembl chr 3:140,420,389...140,453,583
JBrowse link
G Ano1 anoctamin 1 increases expression ISO tetrachloroisophthalonitrile results in increased expression of ANO1 mRNA CTD PMID:33246813 NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO tetrachloroisophthalonitrile results in increased expression of BAX protein CTD PMID:30586609 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of BCL2 protein CTD PMID:30586609 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bmp15 bone morphogenetic protein 15 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of BMP15 protein CTD PMID:30586609 NCBI chr  X:16,169,123...16,174,187
Ensembl chr  X:16,169,123...16,174,187
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of CCL2 mRNA CTD PMID:32289622 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of CCL4 mRNA CTD PMID:32289622 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Cftr CF transmembrane conductance regulator decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of CFTR protein
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of CFTR protein; [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of CFTR mRNA
CTD PMID:33246813 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of COL1A1 mRNA; tetrachloroisophthalonitrile metabolite results in increased expression of COL1A1 protein CTD PMID:32289622 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of CPT1A mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of CPT1A mRNA
CTD PMID:33246813 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of CXCL2 mRNA CTD PMID:32289622 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of CYP11A1 protein CTD PMID:30586609 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Defa10 defensin alpha 10 multiple interactions ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of DEFA3 mRNA CTD PMID:33246813 NCBI chr16:70,514,248...70,515,024
Ensembl chr16:70,514,248...70,515,024
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions
decreases expression
ISO [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of DGAT1 mRNA
tetrachloroisophthalonitrile results in decreased expression of DGAT1 mRNA
CTD PMID:33246813 NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of DGAT2 mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of DGAT2 mRNA
CTD PMID:33246813 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO tetrachloroisophthalonitrile results in decreased activity of DIO1 protein CTD PMID:29228274 PMID:30561685 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO tetrachloroisophthalonitrile results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO tetrachloroisophthalonitrile results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
JBrowse link
G Egfr epidermal growth factor receptor decreases phosphorylation ISO tetrachloroisophthalonitrile results in decreased phosphorylation of EGFR protein CTD PMID:28426875 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases activity ISO tetrachloroisophthalonitrile results in increased activity of ERBB2 protein CTD PMID:11222871 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of FABP1 mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of FABP1 mRNA
CTD PMID:33246813 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fasn fatty acid synthase decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of FASN mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of FASN mRNA
CTD PMID:33246813 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fshr follicle stimulating hormone receptor decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of FSHR protein CTD PMID:30586609 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
JBrowse link
G Gck glucokinase multiple interactions
decreases expression
ISO [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of GCK mRNA
tetrachloroisophthalonitrile results in decreased expression of GCK mRNA
CTD PMID:33246813 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
JBrowse link
G Gdf9 growth differentiation factor 9 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of GDF9 protein CTD PMID:30586609 NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of GJA1 protein CTD PMID:30586609 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial multiple interactions
decreases expression
ISO [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of GPAM mRNA
tetrachloroisophthalonitrile results in decreased expression of GPAM mRNA
CTD PMID:33246813 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of HSD17B4 protein CTD PMID:30586609 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of HSD3B1 protein CTD PMID:30586609 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of IL1A mRNA CTD PMID:32289622 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of IL1B mRNA CTD PMID:32289622 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of IL6 mRNA CTD PMID:32289622 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Klf4 Kruppel like factor 4 multiple interactions
increases expression
ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of KLF4 mRNA
tetrachloroisophthalonitrile results in increased expression of KLF4 mRNA
CTD PMID:33246813 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO tetrachloroisophthalonitrile results in decreased phosphorylation of MAPK1 protein CTD PMID:28426875 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO tetrachloroisophthalonitrile results in decreased phosphorylation of MAPK3 protein CTD PMID:28426875 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mep1b meprin A subunit beta multiple interactions
increases expression
ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of MEP1B mRNA
tetrachloroisophthalonitrile results in increased expression of MEP1B mRNA
CTD PMID:33246813 NCBI chr18:12,366,126...12,392,840
Ensembl chr18:12,365,289...12,392,840
JBrowse link
G Mif macrophage migration inhibitory factor decreases expression ISO tetrachloroisophthalonitrile metabolite results in decreased expression of MIF mRNA CTD PMID:32289622 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
JBrowse link
G Mlxip MLX interacting protein multiple interactions ISO [procymidone co-treated with tetrachloroisophthalonitrile] results in increased expression of MLXIP mRNA CTD PMID:33246813 NCBI chr12:33,128,524...33,192,300
Ensembl chr12:33,128,520...33,192,374
JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases expression ISO tetrachloroisophthalonitrile metabolite results in decreased expression of MMP1 mRNA CTD PMID:32289622 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression ISO tetrachloroisophthalonitrile metabolite results in decreased expression of MMP3 mRNA CTD PMID:32289622 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of MMP9 mRNA CTD PMID:32289622 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of MTTP mRNA CTD PMID:33246813 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
G Muc1 mucin 1, cell surface associated increases expression ISO tetrachloroisophthalonitrile results in increased expression of MUC1 mRNA CTD PMID:33246813 NCBI chr 2:174,635,559...174,640,738
Ensembl chr 2:174,635,995...174,640,733
JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming increases expression
decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in increased expression of MUC2 mRNA
tetrachloroisophthalonitrile results in decreased expression of MUC2 protein
[tetrachloroisophthalonitrile co-treated with procymidone] results in decreased expression of MUC2 protein
CTD PMID:33246813 NCBI chr 1:196,796,257...196,831,740 JBrowse link
G Muc3 mucin 3, intestinal multiple interactions ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of MUC3 mRNA CTD PMID:33246813 NCBI chr12:19,527,251...19,536,924 JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO tetrachloroisophthalonitrile results in increased activity of NR1I2 protein CTD PMID:20143881 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Pklr pyruvate kinase L/R decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of PKLR mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of PKLR mRNA
CTD PMID:33246813 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of PLA2G4A mRNA CTD PMID:33246813 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of PPARA mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of PPARA mRNA
CTD PMID:33246813 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of PPARG mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of PPARG mRNA
CTD PMID:33246813 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of PTGS2 mRNA CTD PMID:32289622 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rad51 RAD51 recombinase increases expression ISO tetrachloroisophthalonitrile results in increased expression of RAD51 protein CTD PMID:30586609 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of S100A8 mRNA CTD PMID:32289622 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 decreases expression ISO tetrachloroisophthalonitrile metabolite results in decreased expression of S100A9 mRNA CTD PMID:32289622 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
decreases expression
ISO [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of SCD1 mRNA
tetrachloroisophthalonitrile results in decreased expression of SCD1 mRNA
CTD PMID:33246813 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of SLC12A2 mRNA CTD PMID:33246813 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440
JBrowse link
G Slc26a3 solute carrier family 26 member 3 multiple interactions
increases expression
ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of SLC26A3 mRNA
tetrachloroisophthalonitrile results in increased expression of SLC26A3 mRNA
CTD PMID:33246813 NCBI chr 6:48,023,892...48,064,829
Ensembl chr 6:48,023,892...48,064,772
JBrowse link
G Slc26a6 solute carrier family 26 member 6 increases expression ISO tetrachloroisophthalonitrile results in increased expression of SLC26A6 mRNA CTD PMID:33246813 NCBI chr 8:109,558,968...109,569,778
Ensembl chr 8:109,559,642...109,569,778
JBrowse link
G Slc27a2 solute carrier family 27 member 2 decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of SLC27A2 mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of SLC27A2 mRNA
CTD PMID:33246813 NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208
JBrowse link
G Slc9a3 solute carrier family 9 member A3 multiple interactions
increases expression
ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of SLC9A3 mRNA
tetrachloroisophthalonitrile results in increased expression of SLC9A3 mRNA
CTD PMID:33246813 NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity ISO tetrachloroisophthalonitrile results in decreased activity of TGFB1 protein CTD PMID:31652400 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tlr4 toll-like receptor 4 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of TLR4 mRNA CTD PMID:32289622 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of TNF mRNA CTD PMID:32289622 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      group 19733
        pseudohalo group 3489
          cyano group 3489
            nitrile 3489
              isophthalonitrile 68
                4-hydroxychlorothalonil 0
                chlorothalonil 68
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        aromatic carboxylic acid 11708
                                          benzoic acids 11681
                                            benzenedicarboxylic acid 7761
                                              isophthalic acid 124
                                                isophthalonitrile 68
                                                  4-hydroxychlorothalonil 0
                                                  chlorothalonil 68
paths to the root