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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aminopyridine
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Accession:CHEBI:38207 term browser browse the term
Definition:Compounds containing a pyridine skeleton substituted by one or more amine groups.
Synonyms:related_synonym: aminopyridines



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2,4-diaminopyridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alk ALK receptor tyrosine kinase multiple interactions ISO 2,4-diaminopyridine analog binds to and results in decreased activity of ALK protein CTD PMID:22564207 NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034
JBrowse link
4-aminopyridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1b adrenoceptor alpha 1B multiple interactions EXP 4-Aminopyridine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine] CTD PMID:18480251 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP 4-Aminopyridine results in increased expression of BAX mRNA CTD PMID:24378259 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression EXP 4-Aminopyridine results in decreased expression of BIRC2 mRNA CTD PMID:24378259 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression EXP 4-Aminopyridine results in decreased expression of BIRC3 mRNA CTD PMID:24378259 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Bmf Bcl2 modifying factor increases expression EXP 4-Aminopyridine results in increased expression of BMF mRNA CTD PMID:24378259 NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
JBrowse link
G Casp3 caspase 3 increases activity EXP 4-Aminopyridine results in increased activity of CASP3 protein CTD PMID:24378259 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity EXP 4-Aminopyridine results in increased activity of CASP7 protein CTD PMID:24378259 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp9 caspase 9 increases activity EXP 4-Aminopyridine results in increased activity of CASP9 protein CTD PMID:24378259 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cd40 CD40 molecule increases expression EXP 4-Aminopyridine results in increased expression of CD40 mRNA CTD PMID:24378259 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd40lg CD40 ligand increases expression EXP 4-Aminopyridine results in increased expression of CD40LG mRNA CTD PMID:24378259 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Ctsb cathepsin B increases expression EXP 4-Aminopyridine results in increased expression of CTSB mRNA CTD PMID:24378259 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Dpysl4 dihydropyrimidinase-like 4 increases expression EXP 4-Aminopyridine results in increased expression of DPYSL4 mRNA CTD PMID:24378259 NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914
JBrowse link
G Gad2 glutamate decarboxylase 2 increases expression
multiple interactions
EXP 4-Aminopyridine results in increased expression of GAD2 mRNA
KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of GAD2 mRNA]
CTD PMID:25917026 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
JBrowse link
G Galnt5 polypeptide N-acetylgalactosaminyltransferase 5 decreases expression EXP 4-Aminopyridine results in decreased expression of GALNT5 mRNA CTD PMID:24378259 NCBI chr 3:42,573,622...42,619,881
Ensembl chr 3:42,573,622...42,619,881
JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D multiple interactions ISO [Bicuculline co-treated with 4-Aminopyridine] results in decreased expression of GRIN2D protein CTD PMID:19911010 NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793
JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions EXP [Bicuculline co-treated with 4-Aminopyridine] affects the localization of HDAC5 protein CTD PMID:15773917 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
JBrowse link
G Jph3 junctophilin 3 increases expression EXP 4-Aminopyridine results in increased expression of JPH3 mRNA CTD PMID:24378259 NCBI chr19:49,793,967...49,855,338
Ensembl chr19:49,793,092...49,855,338
JBrowse link
G Kcna10 potassium voltage-gated channel subfamily A member 10 multiple interactions ISO 4-Aminopyridine inhibits the reaction [KCNA10 protein results in increased transport of Potassium] CTD PMID:10836990 NCBI chr 2:194,786,500...194,798,575
Ensembl chr 2:194,786,500...194,798,575
JBrowse link
G Kcnd3 potassium voltage-gated channel subfamily D member 3 increases expression
multiple interactions
EXP 4-Aminopyridine results in increased expression of KCND3 mRNA
KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of KCND3 mRNA]
CTD PMID:25917026 NCBI chr 2:192,937,950...193,155,345
Ensembl chr 2:192,937,950...193,155,345
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO 4-Aminopyridine results in decreased activity of KCNH2 protein CTD PMID:19915712 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kcnip1 potassium voltage-gated channel interacting protein 1 decreases expression
increases expression
multiple interactions
EXP 4-Aminopyridine results in decreased expression of KCNIP1 mRNA
4-Aminopyridine results in increased expression of KCNIP1 mRNA
KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased abundance of gamma-Aminobutyric Acid]; KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of GAD2 mRNA]; KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of KCND3 mRNA]
CTD PMID:24378259 PMID:25917026 NCBI chr10:18,219,519...18,588,833
Ensembl chr10:18,219,519...18,589,045
JBrowse link
G Mag myelin-associated glycoprotein decreases expression EXP 4-Aminopyridine results in decreased expression of MAG mRNA CTD PMID:24378259 NCBI chr 1:86,148,227...86,163,726
Ensembl chr 1:86,148,228...86,163,656
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases expression EXP 4-Aminopyridine results in increased expression of MAP1LC3A mRNA CTD PMID:24378259 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK1 protein; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK1 protein]
4-Aminopyridine results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein]; [4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of MAPK1 protein; ciproxifan inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein]; hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein]; typhaneoside inhibits the reaction [[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of MAPK1 protein]
CTD PMID:19911010 PMID:22759588 PMID:28132918 PMID:33621091 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK3 protein; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK3 protein]
4-Aminopyridine results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein]; [4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of MAPK3 protein; ciproxifan inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein]; hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein]; typhaneoside inhibits the reaction [[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of MAPK3 protein]
CTD PMID:19911010 PMID:22759588 PMID:28132918 PMID:33621091 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]; [Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein; KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]; STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein] CTD PMID:15773917 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319
JBrowse link
G Olr1583 olfactory receptor 1583 decreases expression EXP 4-Aminopyridine results in decreased expression of OLR1583 mRNA CTD PMID:24378259 NCBI chr13:85,680,581...85,681,522
Ensembl chr13:85,675,947...85,683,643
JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions EXP [Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]; KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]; STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]] CTD PMID:15773917 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G RGD1311517 similar to RIKEN cDNA 9430015G10 increases expression EXP 4-Aminopyridine results in increased expression of C1ORF159 mRNA CTD PMID:24378259 NCBI chr 5:166,701,485...166,719,939
Ensembl chr 5:166,701,676...166,719,955
JBrowse link
G S100a7a S100 calcium binding protein A7A decreases expression EXP 4-Aminopyridine results in decreased expression of S100A7A mRNA CTD PMID:24378259 NCBI chr 2:176,151,405...176,155,846
Ensembl chr 2:176,151,288...176,156,441
JBrowse link
G Syn1 synapsin I affects response to substance
multiple interactions
increases response to substance
increases expression
ISO
EXP
SYN1 protein affects the susceptibility to 4-Aminopyridine
[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of SYN1 protein; ciproxifan inhibits the reaction [4-Aminopyridine results in increased expression of SYN1 protein modified form]; typhaneoside inhibits the reaction [[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of SYN1 protein]
SYN1 results in increased susceptibility to 4-Aminopyridine
CTD PMID:22759588 PMID:28132918 PMID:33621091 NCBI chr  X:1,172,208...1,227,400
Ensembl chr  X:1,172,208...1,227,396
JBrowse link
G Traf2 Tnf receptor-associated factor 2 increases expression EXP 4-Aminopyridine results in increased expression of TRAF2 mRNA CTD PMID:24378259 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
JBrowse link
6-aminonicotinamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif4a1 eukaryotic translation initiation factor 4A1 multiple interactions ISO [6-Aminonicotinamide co-treated with spautin-1] results in increased degradation of EIF4A1 protein CTD PMID:30821613 NCBI chr10:54,384,345...54,389,853
Ensembl chr10:54,384,347...54,389,858
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases expression
ISO IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of FGF2 protein] CTD PMID:12898533 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO 6-Aminonicotinamide inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein] CTD PMID:25246272 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO 6-Aminonicotinamide inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 protein] CTD PMID:25246272 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of IL1B protein] CTD PMID:12898533 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO 6-Aminonicotinamide promotes the reaction [IL6 protein results in increased expression of MT1 protein]; 6-Aminonicotinamide promotes the reaction [IL6 protein results in increased expression of MT2 protein]; IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of FGF2 protein]; IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of IL1B protein]; IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of NTF3 protein]; IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of TGFB1 protein]; IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of TNF protein]
6-Aminonicotinamide results in increased expression of IL6 protein
CTD PMID:12898533 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mt1 metallothionein 1 multiple interactions
increases expression
decreases response to substance
ISO 6-Aminonicotinamide promotes the reaction [IL6 protein results in increased expression of MT1 protein]
6-Aminonicotinamide results in increased expression of MT1 protein
MT1 protein results in decreased susceptibility to 6-Aminonicotinamide
CTD PMID:11835189 PMID:12898533 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mt2A metallothionein 2A multiple interactions
increases expression
decreases response to substance
ISO 6-Aminonicotinamide promotes the reaction [IL6 protein results in increased expression of MT2 protein]
6-Aminonicotinamide results in increased expression of MT2 protein
MT2 protein results in decreased susceptibility to 6-Aminonicotinamide
CTD PMID:11835189 PMID:12898533 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mt3 metallothionein 3 increases expression ISO 6-Aminonicotinamide results in increased expression of MT3 protein CTD PMID:10785446 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
JBrowse link
G Ntf3 neurotrophin 3 increases expression
multiple interactions
ISO 6-Aminonicotinamide results in increased expression of NTF3 protein
IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of NTF3 protein]
CTD PMID:12898533 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO 6-Aminonicotinamide inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein] CTD PMID:25246272 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Sox17 SRY-box transcription factor 17 decreases localization ISO 6-Aminonicotinamide results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
ISO IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of TGFB1 protein] CTD PMID:12898533 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO 6-Aminonicotinamide results in increased expression of TNF protein
IL6 protein promotes the reaction [6-Aminonicotinamide results in increased expression of TNF protein]
CTD PMID:12898533 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
azaperone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Azaperone results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
BAY 60-6583 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2B receptor multiple interactions EXP BAY 60-6583 binds to and results in increased activity of ADORA2B protein CTD PMID:19749167 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions
increases expression
ISO 1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [[BAY 60-6583 co-treated with cobaltous chloride] results in increased expression of CXCL12 protein]; 1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [BAY 60-6583 results in increased expression of CXCL12 protein]; [BAY 60-6583 co-treated with cobaltous chloride] results in increased expression of CXCL12 protein CTD PMID:27590504 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases expression
ISO 1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [BAY 60-6583 results in increased expression of FGF2 protein]; [BAY 60-6583 co-treated with cobaltous chloride] results in increased expression of FGF2 protein CTD PMID:27590504 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO BAY 60-6583 results in increased phosphorylation of MAPK1 protein CTD PMID:27590504 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO BAY 60-6583 results in increased phosphorylation of MAPK3 protein CTD PMID:27590504 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
CHIR 99021 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadvl acyl-CoA dehydrogenase, very long chain decreases expression ISO Chir 99021 results in decreased expression of ACADVL mRNA CTD PMID:29883716 NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075
JBrowse link
G Acan aggrecan decreases expression ISO Chir 99021 results in decreased expression of ACAN mRNA CTD PMID:32220932 NCBI chr 1:132,981,034...133,044,416
Ensembl chr 1:132,981,582...133,043,627
JBrowse link
G Afp alpha-fetoprotein increases expression ISO Chir 99021 results in increased expression of AFP mRNA CTD PMID:31711903 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Chir 99021 binds to and results in increased activity of AHR protein; Chir 99021 inhibits the reaction [AHR protein results in decreased expression of VIM protein] CTD PMID:26259606 PMID:27752740 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of ALDH1A2 mRNA; [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
JBrowse link
G Apoa1 apolipoprotein A1 increases expression
multiple interactions
ISO Chir 99021 results in increased expression of APOA1 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Chir 99021 results in increased expression of APOA1 mRNA]; [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of APOA1 mRNA]
CTD PMID:31711903 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO Chir 99021 results in increased expression of BGLAP mRNA CTD PMID:32220932 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Chir 99021 affects the reaction [NAMPT protein affects the expression of CCND1 protein] CTD PMID:32005247 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdx1 caudal type homeo box 1 increases expression
multiple interactions
ISO Chir 99021 results in increased expression of CDX1 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of CDX1 mRNA]; Tretinoin inhibits the reaction [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of CDX1 mRNA]]
CTD PMID:31711903 NCBI chr18:54,472,448...54,499,799
Ensembl chr18:54,473,444...54,490,814
JBrowse link
G Ctnnb1 catenin beta 1 increases expression
affects localization
multiple interactions
ISO Chir 99021 results in increased expression of CTNNB1 protein
Chir 99021 affects the localization of CTNNB1 protein
Chir 99021 affects the reaction [NAMPT protein affects the expression of CTNNB1 protein]; Chir 99021 inhibits the reaction [celastrol results in decreased expression of CTNNB1 protein]
CTD PMID:26259606 PMID:31715269 PMID:32005247 PMID:32220932 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Chir 99021 results in increased expression of CYP1A2 mRNA CTD PMID:26259606 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
ISO Chir 99021 results in increased expression of and results in increased activity of CYP2E1 protein
Chir 99021 results in increased expression of CYP2E1 mRNA
CTD PMID:26259606 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO Chir 99021 results in increased expression of CYP3A4 mRNA CTD PMID:26259606 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Eif2b5 eukaryotic translation initiation factor 2B subunit epsilon multiple interactions ISO Chir 99021 promotes the reaction [GSK3B protein affects the phosphorylation of EIF2B5 protein] CTD PMID:29883716 NCBI chr11:80,394,433...80,404,468
Ensembl chr11:80,394,433...80,404,419
JBrowse link
G Esrra estrogen related receptor, alpha increases expression ISO Chir 99021 results in increased expression of ESRRA mRNA CTD PMID:29883716 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EYA1 mRNA; Tretinoin inhibits the reaction [[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EYA1 mRNA] CTD PMID:31711903 NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483
JBrowse link
G Fbxo32 F-box protein 32 decreases expression
multiple interactions
ISO Chir 99021 results in decreased expression of FBXO32 mRNA
Chir 99021 inhibits the reaction [Dexamethasone results in increased expression of FBXO32 mRNA]
CTD PMID:21832246 NCBI chr 7:89,731,626...89,764,761
Ensembl chr 7:89,730,232...89,765,436
JBrowse link
G Fgf8 fibroblast growth factor 8 multiple interactions
increases expression
ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of FGF8 mRNA] CTD PMID:31711903 NCBI chr 1:244,584,477...244,590,359
Ensembl chr 1:244,584,652...244,590,359
JBrowse link
G Foxa1 forkhead box A1 increases expression
multiple interactions
ISO Chir 99021 results in increased expression of FOXA1 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Chir 99021 results in increased expression of FOXA1 mRNA]; [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of FOXA1 mRNA]
CTD PMID:31711903 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
JBrowse link
G Foxc2 forkhead box C2 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXC2 mRNA; Tretinoin inhibits the reaction [[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXC2 mRNA] CTD PMID:31711903 NCBI chr19:49,186,034...49,188,736
Ensembl chr19:49,185,662...49,188,737
JBrowse link
G Gata6 GATA binding protein 6 multiple interactions
increases expression
ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Chir 99021 results in increased expression of GATA6 mRNA]; [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of GATA6 mRNA] CTD PMID:31711903 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects phosphorylation
multiple interactions
decreases activity
ISO Chir 99021 affects the phosphorylation of GSK3B protein
Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium promotes the reaction [GSK3B protein binds to TFEB protein]]; Chir 99021 promotes the reaction [GSK3B protein affects the expression of PPARGC1A protein]; Chir 99021 promotes the reaction [GSK3B protein affects the phosphorylation of EIF2B5 protein]
Chir 99021 results in decreased activity of GSK3B protein
CTD PMID:27752740 PMID:29883716 PMID:30165626 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hes5 hes family bHLH transcription factor 5 multiple interactions ISO [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of HES5 mRNA CTD PMID:20865013 NCBI chr 5:165,522,138...165,523,684
Ensembl chr 5:165,522,234...165,523,001
JBrowse link
G Hes7 hes family bHLH transcription factor 7 increases expression
multiple interactions
ISO Chir 99021 results in increased expression of HES7 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of HES7 mRNA]; Tretinoin inhibits the reaction [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of HES7 mRNA]]
CTD PMID:31711903 NCBI chr10:53,824,124...53,828,350
Ensembl chr10:53,825,574...53,828,097
JBrowse link
G Hoxb1 homeo box B1 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HOXB1 mRNA CTD PMID:31711903 NCBI chr10:81,331,507...81,332,928
Ensembl chr10:81,331,507...81,332,836
JBrowse link
G Hoxb3 homeo box B3 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HOXB3 mRNA CTD PMID:31711903 NCBI chr10:81,258,739...81,314,134
Ensembl chr10:81,299,357...81,313,107
JBrowse link
G Hoxb5 homeo box B5 multiple interactions ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide affects the reaction [Chir 99021 results in increased expression of HOXB5 mRNA]; Tretinoin affects the reaction [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide affects the reaction [Chir 99021 results in increased expression of HOXB5 mRNA]] CTD PMID:31711903 NCBI chr10:81,269,372...81,271,580
Ensembl chr10:81,269,372...81,271,580
JBrowse link
G Hoxb7 homeo box B7 increases expression
multiple interactions
ISO Chir 99021 results in increased expression of HOXB7 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of HOXB7 mRNA]
CTD PMID:31711903 NCBI chr10:81,252,616...81,256,034
Ensembl chr10:81,252,553...81,256,034
JBrowse link
G Hoxb9 homeo box B9 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818
JBrowse link
G Ihh Indian hedgehog signaling molecule multiple interactions
increases expression
ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Chir 99021 results in increased expression of IHH mRNA]; [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of IHH mRNA] CTD PMID:31711903 NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions ISO Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of LAMP1 protein] CTD PMID:30165626 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
JBrowse link
G Lgr5 leucine rich repeat containing G protein coupled receptor 5 increases expression ISO Chir 99021 results in increased expression of LGR5 mRNA CTD PMID:26259606 NCBI chr 7:51,087,059...51,221,882
Ensembl chr 7:51,088,239...51,222,446
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha multiple interactions ISO Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of MAP1LC3A protein] CTD PMID:30165626 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
JBrowse link
G Meox1 mesenchyme homeobox 1 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MEOX1 mRNA; Tretinoin inhibits the reaction [[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MEOX1 mRNA] CTD PMID:31711903 NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660
JBrowse link
G Mesp2 mesoderm posterior bHLH transcription factor 2 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MESP2 mRNA; Tretinoin inhibits the reaction [[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MESP2 mRNA] CTD PMID:31711903 NCBI chr 1:133,756,601...133,759,207
Ensembl chr 1:133,756,601...133,759,198
JBrowse link
G Mpp1 MAGUK p55 scaffold protein 1 multiple interactions
increases expression
ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Chir 99021 results in increased expression of MPP1 mRNA]; [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of MPP1 mRNA] CTD PMID:31711903
G Msgn1 mesogenin 1 increases expression
multiple interactions
ISO Chir 99021 results in increased expression of MSGN1 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of MSGN1 mRNA]; Tretinoin inhibits the reaction [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of MSGN1 mRNA]]
CTD PMID:31711903 NCBI chr 6:33,912,787...33,913,427
Ensembl chr 6:33,912,787...33,913,427
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Chir 99021 results in increased expression of MYC protein CTD PMID:25897075 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions ISO Chir 99021 affects the reaction [NAMPT protein affects the expression of CCND1 protein]; Chir 99021 affects the reaction [NAMPT protein affects the expression of CTNNB1 protein] CTD PMID:32005247 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
JBrowse link
G Nanog Nanog homeobox decreases expression ISO Chir 99021 results in decreased expression of NANOG mRNA CTD PMID:31711903 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Nes nestin multiple interactions ISO [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of NES mRNA CTD PMID:20865013 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Neurog2 neurogenin 2 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 2:216,092,641...216,095,276
Ensembl chr 2:216,093,363...216,094,154
JBrowse link
G Nodal nodal growth differentiation factor multiple interactions
increases expression
ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Chir 99021 results in increased expression of NODAL mRNA]; [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of NODAL mRNA] CTD PMID:31711903 NCBI chr20:29,368,436...29,376,837
Ensembl chr20:29,368,436...29,376,837
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Chir 99021 binds to and results in increased activity of NR1I2 protein CTD PMID:26259606 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nrf1 nuclear respiratory factor 1 decreases expression ISO Chir 99021 results in decreased expression of NRF1 mRNA CTD PMID:29883716 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
JBrowse link
G Olig3 oligodendrocyte transcription factor 3 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 1:14,081,259...14,083,336
Ensembl chr 1:14,081,328...14,082,149
JBrowse link
G Pax3 paired box 3 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of PAX3 mRNA; [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042
JBrowse link
G Pax6 paired box 6 multiple interactions
increases expression
ISO [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] promotes the reaction [Chir 99021 results in increased expression of PAX6 mRNA] CTD PMID:31711903 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
JBrowse link
G Perm1 PPARGC1 and ESRR induced regulator, muscle 1 increases expression ISO Chir 99021 results in increased expression of PERM1 mRNA CTD PMID:29883716 NCBI chr 5:166,800,030...166,805,323
Ensembl chr 5:166,800,030...166,805,323
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO Chir 99021 results in decreased expression of POU5F1 mRNA CTD PMID:31711903 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Chir 99021 results in decreased expression of PPARA mRNA CTD PMID:29883716 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta decreases expression ISO Chir 99021 results in decreased expression of PPARD mRNA CTD PMID:29883716 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression
ISO Chir 99021 promotes the reaction [GSK3B protein affects the expression of PPARGC1A protein]
Chir 99021 results in increased expression of PPARGC1A mRNA; Chir 99021 results in increased expression of PPARGC1A protein
CTD PMID:29883716 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 increases expression ISO Chir 99021 results in increased expression of RICTOR protein CTD PMID:25897075 NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO Chir 99021 results in increased expression of RUNX2 mRNA CTD PMID:32220932 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Sox17 SRY-box transcription factor 17 multiple interactions
increases expression
ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Chir 99021 results in increased expression of SOX17 mRNA]; [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of SOX17 mRNA] CTD PMID:31711903 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228
JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression
multiple interactions
ISO Chir 99021 results in decreased expression of SOX2 mRNA
[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in decreased expression of SOX2 mRNA]
CTD PMID:31711903 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression ISO Chir 99021 results in decreased expression of SOX9 mRNA CTD PMID:32220932 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
JBrowse link
G Sp7 Sp7 transcription factor increases expression
affects localization
ISO Chir 99021 results in increased expression of SP7 mRNA
Chir 99021 affects the localization of SP7 protein
CTD PMID:32220932 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SQSTM1 protein] CTD PMID:30165626 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Syp synaptophysin multiple interactions ISO [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of SYP mRNA CTD PMID:20865013 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link
G Tbx1 T-box transcription factor 1 multiple interactions
increases expression
ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of BRACHYURY mRNA]; [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of BRACHYURY mRNA CTD PMID:31711903 NCBI chr11:82,409,275...82,419,058
Ensembl chr11:82,409,275...82,418,380
JBrowse link
G Tbx6 T-box transcription factor 6 increases expression
multiple interactions
ISO Chir 99021 results in increased expression of TBX6 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of TBX6 mRNA]; Tretinoin inhibits the reaction [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of TBX6 mRNA]]
CTD PMID:31711903 NCBI chr 1:181,387,851...181,392,762
Ensembl chr 1:181,388,684...181,392,593
JBrowse link
G Tcf15 transcription factor 15 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of TCF15 mRNA; [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr 3:140,638,984...140,644,766
Ensembl chr 3:140,638,984...140,644,766
JBrowse link
G Tfeb transcription factor EB multiple interactions ISO Chir 99021 affects the reaction [1-Methyl-4-phenylpyridinium affects the localization of TFEB protein]; Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium promotes the reaction [GSK3B protein binds to TFEB protein]]; Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium promotes the reaction [YWHAQ protein binds to TFEB protein]] CTD PMID:30165626 NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions ISO [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of TUBB3 mRNA CTD PMID:20865013 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243
JBrowse link
G Uncx UNC homeobox multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNCX mRNA; Tretinoin inhibits the reaction [[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNCX mRNA] CTD PMID:31711903 NCBI chr12:15,092,779...15,097,300
Ensembl chr12:15,092,784...15,097,300
JBrowse link
G Vim vimentin multiple interactions ISO Chir 99021 inhibits the reaction [AHR protein results in decreased expression of VIM protein] CTD PMID:27752740 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Wnt3a Wnt family member 3A increases expression
multiple interactions
ISO Chir 99021 results in increased expression of WNT3A mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of WNT3A mRNA]; [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of WNT3A mRNA
CTD PMID:31711903 NCBI chr10:44,034,174...44,078,463
Ensembl chr10:44,034,194...44,078,324
JBrowse link
G Wnt5a Wnt family member 5A increases expression
multiple interactions
ISO Chir 99021 results in increased expression of WNT5A mRNA
[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of WNT5A mRNA; [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT5A mRNA
CTD PMID:31711903 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta multiple interactions ISO Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium promotes the reaction [YWHAQ protein binds to TFEB protein]] CTD PMID:30165626 NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273
JBrowse link
CHIR-98014 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nanog Nanog homeobox decreases expression ISO Chir 98014 results in decreased expression of NANOG mRNA CTD PMID:22723015 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Otx2 orthodenticle homeobox 2 decreases expression ISO Chir 98014 results in decreased expression of OTX2 mRNA CTD PMID:22723015 NCBI chr15:21,942,233...21,953,034
Ensembl chr15:21,943,191...21,953,416
JBrowse link
G Pax6 paired box 6 decreases expression ISO Chir 98014 results in decreased expression of PAX6 mRNA CTD PMID:22723015 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
JBrowse link
crizotinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity
ISO crizotinib inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; crizotinib inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; crizotinib promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]
crizotinib results in decreased activity of ABCB1 protein
CTD PMID:22233293 PMID:28369651 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases activity ISO crizotinib results in decreased activity of ABCG2 protein CTD PMID:28369651 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase decreases activity ISO crizotinib results in decreased activity of ABL1 protein CTD PMID:21812414 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO crizotinib results in increased phosphorylation of ACACA protein CTD PMID:23707608 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO crizotinib results in decreased phosphorylation of AKT1 protein
EGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of AKT1 protein]; HBEGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of AKT1 protein]; MET gene mutant form promotes the reaction [crizotinib results in decreased phosphorylation of AKT1 protein]; TGFA protein inhibits the reaction [crizotinib results in decreased phosphorylation of AKT1 protein]
CTD PMID:22553343 PMID:22729845 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alk ALK receptor tyrosine kinase decreases response to substance
affects response to substance
decreases activity
increases mutagenesis
decreases stability
decreases phosphorylation
multiple interactions
ISO ALK gene mutant form results in decreased susceptibility to crizotinib; ALK gene SNP results in decreased susceptibility to crizotinib; ALK protein mutant form results in decreased susceptibility to crizotinib
ALK protein affects the susceptibility to crizotinib
crizotinib results in decreased activity of ALK protein mutant form
crizotinib results in increased mutagenesis of ALK gene mutant form; crizotinib results in increased mutagenesis of ALK protein mutant form
crizotinib results in decreased stability of ALK protein mutant form
crizotinib results in decreased phosphorylation of ALK protein; crizotinib results in decreased phosphorylation of ALK protein mutant form
Crizotinib results in decreased activity of ALK protein; Crizotinib results in decreased activity of ALK protein mutant form
[ALK protein mutant form promotes the reaction [ALK protein binds to Adenosine Triphosphate]] which results in decreased susceptibility to crizotinib; [crizotinib results in increased mutagenesis of ALK gene mutant form] which results in decreased susceptibility to crizotinib; [crizotinib results in increased mutagenesis of ALK protein mutant form] which results in decreased susceptibility to crizotinib; [crizotinib results in increased mutagenesis of ALK protein mutant form] which results in increased activity of ALK protein; [Ethylnitrosourea results in increased mutagenesis of ALK protein] inhibits the reaction [crizotinib results in decreased phosphorylation of ALK protein]; [Ethylnitrosourea results in increased mutagenesis of ALK protein] which results in decreased susceptibility to crizotinib; ALK gene SNP inhibits the reaction [crizotinib results in decreased phosphorylation of ALK protein mutant form]; ALK protein mutant form inhibits the reaction [crizotinib binds to and results in decreased activity of ALK protein]; ALK protein mutant form inhibits the reaction [crizotinib results in decreased activity of ALK protein]; ALK protein mutant form inhibits the reaction [crizotinib results in decreased phosphorylation of ALK protein]; crizotinib inhibits the reaction [ALK protein mutant form results in increased phosphorylation of MAPK1 protein]; crizotinib inhibits the reaction [ALK protein mutant form results in increased phosphorylation of MAPK3 protein]; crizotinib inhibits the reaction [ALK protein results in increased expression of MYCN mRNA]; crizotinib inhibits the reaction [ALK protein results in increased expression of MYCN protein]; crizotinib results in decreased phosphorylation of and results in decreased activity of ALK protein mutant form
CTD PMID:20979473 PMID:21030459 PMID:21502504 PMID:21767331 PMID:21791641 More... NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression
multiple interactions
affects response to substance
ISO crizotinib results in increased expression of BCL2L11 protein
BCL2L11 protein affects the reaction [crizotinib results in increased cleavage of CASP3 protein]; MET gene mutant form promotes the reaction [crizotinib results in increased expression of BCL2L11 protein]
BCL2L11 protein affects the susceptibility to crizotinib
CTD PMID:22729845 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression
multiple interactions
ISO crizotinib results in decreased expression of BIRC2 protein
MET gene mutant form promotes the reaction [crizotinib results in increased expression of BIRC2 protein]
CTD PMID:22729845 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions
ISO crizotinib results in decreased expression of BIRC5 protein
MET gene mutant form promotes the reaction [crizotinib results in increased expression of BIRC5 protein]
CTD PMID:22729845 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C decreases activity ISO crizotinib results in decreased activity of CACNA1C protein CTD PMID:23707608 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
ISO BCL2L11 protein affects the reaction [crizotinib results in increased cleavage of CASP3 protein]; MET gene mutant form promotes the reaction [crizotinib results in increased cleavage of CASP3 protein]
[crizotinib co-treated with 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one] results in increased cleavage of CASP3 protein
crizotinib results in increased activity of CASP3 protein
CTD PMID:22729845 PMID:22789543 PMID:23707608 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity ISO crizotinib results in increased activity of CASP7 protein CTD PMID:23707608 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases cleavage ISO Crizotinib results in increased cleavage of CASP8 protein CTD PMID:31706006 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cd44 CD44 molecule (Indian blood group) decreases expression ISO crizotinib results in decreased expression of CD44 mRNA; crizotinib results in decreased expression of CD44 protein CTD PMID:22973962 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cda cytidine deaminase decreases expression
multiple interactions
ISO crizotinib results in decreased expression of CDA protein
[crizotinib results in decreased expression of CDA protein] which results in increased susceptibility to gemcitabine
CTD PMID:22973962 NCBI chr 5:150,556,615...150,583,231
Ensembl chr 5:150,556,615...150,583,231
JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein multiple interactions ISO [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of CRKL protein CTD PMID:22683780 NCBI chr11:83,528,788...83,563,214
Ensembl chr11:83,526,530...83,563,238
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO Crizotinib results in increased expression of CYP3A4 mRNA CTD PMID:23129213 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Egf epidermal growth factor multiple interactions
decreases response to substance
ISO EGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of AKT1 protein]; EGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of MAPK1 protein]; EGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of MAPK3 protein]; EGFR protein promotes the reaction [EGF protein results in decreased susceptibility to crizotinib]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in decreased susceptibility to crizotinib] CTD PMID:22553343 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor decreases response to substance
multiple interactions
ISO EGFR protein mutant form results in decreased susceptibility to crizotinib; EGFR protein results in decreased susceptibility to crizotinib
[EGFR protein results in increased phosphorylation of EGFR protein] which results in decreased susceptibility to crizotinib; EGFR protein promotes the reaction [EGF protein results in decreased susceptibility to crizotinib]; EGFR protein promotes the reaction [HBEGF protein results in decreased susceptibility to crizotinib]; EGFR protein promotes the reaction [TGFA protein results in decreased susceptibility to crizotinib]
CTD PMID:21791641 PMID:22235099 PMID:22277784 PMID:22553343 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eml4 EMAP like 4 decreases stability
multiple interactions
increases mutagenesis
ISO crizotinib results in decreased stability of EML4 protein mutant form
[crizotinib results in increased mutagenesis of EML4 gene mutant form] which results in decreased susceptibility to crizotinib
CTD PMID:21502504 PMID:22912387 NCBI chr 6:11,219,545...11,334,824
Ensembl chr 6:11,219,566...11,334,879
JBrowse link
G Epcam epithelial cell adhesion molecule decreases expression ISO crizotinib results in decreased expression of EPCAM mRNA; crizotinib results in decreased expression of EPCAM protein CTD PMID:22973962 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO crizotinib results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fads2 fatty acid desaturase 2 increases expression ISO crizotinib results in increased expression of FADS2 mRNA CTD PMID:23707608 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
JBrowse link
G Fasn fatty acid synthase increases expression ISO crizotinib results in increased expression of FASN mRNA CTD PMID:23707608 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 multiple interactions ISO [PD 173074 results in decreased activity of FGFR1 protein] inhibits the reaction [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] CTD PMID:22683780 NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases secretion ISO crizotinib results in decreased secretion of FSHB protein CTD PMID:22488744 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Gpt glutamic--pyruvic transaminase increases secretion ISO Crizotinib results in increased secretion of GPT protein CTD PMID:29655783 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions
decreases response to substance
ISO EGFR protein promotes the reaction [HBEGF protein results in decreased susceptibility to crizotinib]; Erlotinib Hydrochloride inhibits the reaction [HBEGF protein results in decreased susceptibility to crizotinib]; HBEGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of AKT1 protein]; HBEGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of MAPK1 protein]; HBEGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of MAPK3 protein] CTD PMID:22553343 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of CRKL protein; [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of MAPK1 protein; [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of MAPK3 protein; [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of STAT3 protein; [crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein; [PD 173074 results in decreased activity of FGFR1 protein] inhibits the reaction [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] CTD PMID:22683780 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO crizotinib results in increased expression of HMGCR mRNA CTD PMID:23707608 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO crizotinib results in increased expression of HMGCS1 mRNA CTD PMID:23707608 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO crizotinib results in increased expression of INSIG1 mRNA CTD PMID:23707608 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 decreases phosphorylation ISO Crizotinib results in decreased phosphorylation of IQGAP1 protein CTD PMID:33087447 NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO crizotinib results in decreased activity of KCNH2 protein CTD PMID:23707608 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases response to substance ISO KIT gene mutant form results in decreased susceptibility to crizotinib CTD PMID:22277784 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases response to substance ISO KRAS protein mutant form results in decreased susceptibility to crizotinib CTD PMID:22235099 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases activity ISO crizotinib results in decreased activity of LCK protein CTD PMID:21812414 NCBI chr 5:141,888,319...141,916,992
Ensembl chr 5:141,888,326...141,903,794
JBrowse link
G Lhb luteinizing hormone subunit beta decreases secretion ISO crizotinib results in decreased secretion of LHB protein CTD PMID:22488744 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of MAPK1 protein; [crizotinib results in decreased susceptibility to 5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one] inhibits the reaction [5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in decreased phosphorylation of MAPK1 protein]; crizotinib inhibits the reaction [ALK protein mutant form results in increased phosphorylation of MAPK1 protein]; EGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of MAPK1 protein]; HBEGF protein inhibits the reaction [crizotinib results in decreased phosphorylation of MAPK1 protein]; MET gene mutant form promotes the reaction [crizotinib results in decreased phosphorylation of MAPK1 protein]; TGFA protein inhibits the reaction [crizotinib results in decreased phosphorylation of MAPK1 protein] CTD PMID:21266357 PMID:21502504 PMID:22034911 PMID:22553343 PMID:22683780 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO [[Crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of MAPK3 protein; [Crizotinib results in decreased susceptibility to 5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one] inhibits the reaction [5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in decreased phosphorylation of MAPK3 protein]; Crizotinib inhibits the reaction [ALK protein mutant form results in increased phosphorylation of MAPK3 protein]; EGF protein inhibits the reaction [Crizotinib results in decreased phosphorylation of MAPK3 protein]; HBEGF protein inhibits the reaction [Crizotinib results in decreased phosphorylation of MAPK3 protein]; MET gene mutant form promotes the reaction [Crizotinib results in decreased phosphorylation of MAPK3 protein]; TGFA protein inhibits the reaction [Crizotinib results in decreased phosphorylation of MAPK3 protein]
crizotinib results in decreased phosphorylation of MAPK3 protein
CTD PMID:21266357 PMID:21502504 PMID:22034911 PMID:22553343 PMID:22683780 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases activity
affects response to substance
increases response to substance
increases mutagenesis
multiple interactions
decreases phosphorylation
ISO crizotinib results in decreased activity of MET protein
MET protein affects the susceptibility to Crizotinib
MET gene mutant form results in increased susceptibility to crizotinib
crizotinib results in increased mutagenesis of MET protein
[5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in increased mutagenesis of MET protein] which results in decreased susceptibility to Crizotinib; [[Crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of CRKL protein; [[Crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of MAPK1 protein; [[Crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of MAPK3 protein; [[Crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of STAT3 protein; [Crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein; [Crizotinib results in decreased susceptibility to 5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one] inhibits the reaction [5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in decreased phosphorylation of MET protein]; [Crizotinib results in increased mutagenesis of MET protein] inhibits the reaction [Crizotinib binds to and results in decreased activity of MET protein]; [PD 173074 results in decreased activity of FGFR1 protein] inhibits the reaction [[Crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein]; Crizotinib binds to and results in decreased activity of MET protein; Crizotinib inhibits the reaction [5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one binds to and results in decreased activity of MET protein]; MET gene mutant form promotes the reaction [Crizotinib results in decreased phosphorylation of AKT1 protein]; MET gene mutant form promotes the reaction [Crizotinib results in decreased phosphorylation of MAPK1 protein]; MET gene mutant form promotes the reaction [Crizotinib results in decreased phosphorylation of MAPK3 protein]; MET gene mutant form promotes the reaction [Crizotinib results in decreased phosphorylation of MET protein]; MET gene mutant form promotes the reaction [Crizotinib results in decreased phosphorylation of STAT3 protein]; MET gene mutant form promotes the reaction [Crizotinib results in increased cleavage of CASP3 protein]; MET gene mutant form promotes the reaction [Crizotinib results in increased expression of BCL2L11 protein]; MET gene mutant form promotes the reaction [Crizotinib results in increased expression of BIRC2 protein]; MET gene mutant form promotes the reaction [Crizotinib results in increased expression of BIRC5 protein]; MET gene mutant form promotes the reaction [Crizotinib results in increased expression of XIAP protein]
CTD PMID:21266357 PMID:21405128 PMID:21812414 PMID:22233293 PMID:22683780 More... NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mst1r macrophage stimulating 1 receptor decreases activity ISO crizotinib results in decreased activity of MST1R protein CTD PMID:21812414 NCBI chr 8:108,596,100...108,611,389
Ensembl chr 8:108,597,299...108,612,455
JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor multiple interactions ISO Crizotinib inhibits the reaction [ALK protein results in increased expression of MYCN mRNA]; Crizotinib inhibits the reaction [ALK protein results in increased expression of MYCN protein] CTD PMID:22286764 NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO Crizotinib results in increased cleavage of PARP1 protein
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Crizotinib results in increased cleavage of PARP1 protein]
CTD PMID:31639374 PMID:31706006 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Prom1 prominin 1 decreases expression ISO crizotinib results in decreased expression of PROM1 mRNA; crizotinib results in decreased expression of PROM1 protein CTD PMID:22973962 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
JBrowse link
G Ros1 ROS proto-oncogene 1 , receptor tyrosine kinase decreases phosphorylation ISO crizotinib results in decreased phosphorylation of ROS protein mutant form CTD PMID:22617245 NCBI chr20:31,432,636...31,583,998
Ensembl chr20:31,432,637...31,583,865
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO crizotinib results in decreased phosphorylation of RPS6 protein CTD PMID:22034911 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity ISO crizotinib results in decreased activity of SCN5A protein CTD PMID:23707608 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression ISO crizotinib results in increased expression of SREBF2 mRNA CTD PMID:23707608 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation
multiple interactions
ISO crizotinib results in decreased phosphorylation of STAT3 protein
[[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of STAT3 protein; MET gene mutant form promotes the reaction [crizotinib results in decreased phosphorylation of STAT3 protein]
CTD PMID:22034911 PMID:22553343 PMID:22683780 PMID:22729845 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tek TEK receptor tyrosine kinase decreases activity ISO crizotinib results in decreased activity of TEK protein CTD PMID:21812414 NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions
decreases response to substance
ISO EGFR protein promotes the reaction [TGFA protein results in decreased susceptibility to crizotinib]; Erlotinib Hydrochloride inhibits the reaction [TGFA protein results in decreased susceptibility to crizotinib]; TGFA protein inhibits the reaction [crizotinib results in decreased phosphorylation of AKT1 protein]; TGFA protein inhibits the reaction [crizotinib results in decreased phosphorylation of MAPK1 protein]; TGFA protein inhibits the reaction [crizotinib results in decreased phosphorylation of MAPK3 protein] CTD PMID:22553343 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Twist1 twist family bHLH transcription factor 1 decreases response to substance ISO TWIST1 protein results in decreased susceptibility to crizotinib CTD PMID:22155737 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
G Vim vimentin decreases expression ISO crizotinib results in decreased expression of VIM protein CTD PMID:22973962 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression
multiple interactions
ISO crizotinib results in decreased expression of XIAP protein
MET gene mutant form promotes the reaction [crizotinib results in increased expression of XIAP protein]
CTD PMID:22729845 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
delavirdine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO Delavirdine results in decreased activity of CYP2C19 protein CTD PMID:11225565 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
fluazinam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO fluazinam results in increased expression of BAX protein CTD PMID:21907236 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO fluazinam results in decreased expression of BCL2 protein CTD PMID:21907236 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases activity ISO fluazinam results in increased activity of CASP3 protein CTD PMID:21907236 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO fluazinam results in decreased activity of DIO1 protein CTD PMID:29228274 PMID:30561685 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO fluazinam results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO fluazinam results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
JBrowse link
G Sox17 SRY-box transcription factor 17 decreases localization ISO fluazinam results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228
JBrowse link
G Tp53 tumor protein p53 increases expression ISO fluazinam results in increased expression of TP53 protein CTD PMID:21907236 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
flunixin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity EXP flunixin results in decreased activity of PTGS1 protein CTD PMID:12967936 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
GSK343 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dicer1 dicer 1 ribonuclease III increases expression ISO GSK343 results in increased expression of DICER1 mRNA CTD PMID:25351418 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit decreases activity ISO GSK343 results in decreased activity of EZH2 protein CTD PMID:23759589 PMID:24900432 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
JBrowse link
lorlatinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alk ALK receptor tyrosine kinase multiple interactions ISO lorlatinib results in decreased phosphorylation of and results in decreased activity of ALK protein; lorlatinib results in decreased phosphorylation of and results in decreased activity of ALK protein mutant form CTD PMID:26144315 NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO lorlatinib inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein] CTD PMID:34021354 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ros1 ROS proto-oncogene 1 , receptor tyrosine kinase decreases activity
multiple interactions
ISO lorlatinib results in decreased activity of ROS1 protein mutant form
lorlatinib binds to and results in decreased activity of ROS1 protein
CTD PMID:25733882 NCBI chr20:31,432,636...31,583,998
Ensembl chr20:31,432,637...31,583,865
JBrowse link
N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO flupirtine results in decreased activity of ABCB11 protein CTD PMID:20829430 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO flupirtine results in increased expression of BCL2 protein CTD PMID:9804146 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp2 caspase 2 decreases expression ISO flupirtine results in decreased expression of CASP2 protein CTD PMID:9804146 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Tia1 TIA1 cytotoxic granule-associated RNA binding protein decreases expression ISO flupirtine results in decreased expression of TIA1 protein CTD PMID:9804146 NCBI chr 4:118,852,765...118,883,252
Ensembl chr 4:118,852,837...118,880,586
JBrowse link
palbociclib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO palbociclib results in increased expression of ABCA1 mRNA CTD PMID:22869556 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO BMS 754807 inhibits the reaction [palbociclib results in increased phosphorylation of AKT1 protein]; palbociclib promotes the reaction [idelalisib results in decreased phosphorylation of AKT1 protein] CTD PMID:23676220 PMID:24986516 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Anln anillin, actin binding protein decreases expression ISO palbociclib results in decreased expression of ANLN mRNA CTD PMID:22869556 NCBI chr 8:20,858,227...20,921,602
Ensembl chr 8:20,858,228...20,921,538
JBrowse link
G Apoe apolipoprotein E increases expression ISO palbociclib results in increased expression of APOE mRNA CTD PMID:28620137 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Asf1b anti-silencing function 1B histone chaperone decreases expression ISO palbociclib results in decreased expression of ASF1B mRNA CTD PMID:22869556 NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549
JBrowse link
G Aurka aurora kinase A decreases expression ISO palbociclib results in decreased expression of AURKA mRNA CTD PMID:22869556 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
JBrowse link
G Aurkb aurora kinase B decreases expression ISO palbociclib results in decreased expression of AURKB mRNA CTD PMID:22869556 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
G Bard1 BRCA1 associated RING domain 1 decreases expression ISO palbociclib results in decreased expression of BARD1 mRNA CTD PMID:22869556 PMID:28620137 NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO palbociclib results in decreased expression of BIRC5 mRNA CTD PMID:22869556 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bora bora, aurora kinase A activator decreases expression ISO palbociclib results in decreased expression of BORA mRNA CTD PMID:22869556 NCBI chr15:75,797,624...75,835,599
Ensembl chr15:75,797,891...75,821,322
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression ISO palbociclib results in decreased expression of BUB1 mRNA CTD PMID:22869556 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
decreases cleavage
ISO [palbociclib results in increased susceptibility to idelalisib] which results in increased cleavage of CASP3 protein; palbociclib inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; palbociclib inhibits the reaction [Carboplatin results in increased activity of CASP3 protein]; palbociclib inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; palbociclib inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; palbociclib inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; palbociclib inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]
palbociclib results in increased cleavage of CASP3 protein
[CDKN2A gene mutant form results in increased susceptibility to palbociclib] which affects the activity of CASP3 protein
palbociclib results in decreased cleavage of CASP3 protein
CTD PMID:22302033 PMID:22751436 PMID:23676220 PMID:24098593 PMID:27099147 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions ISO palbociclib inhibits the reaction [Camptothecin results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Carboplatin results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Doxorubicin results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Etoposide results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Paclitaxel results in increased activity of CASP7 protein]
[CDKN2A gene mutant form results in increased susceptibility to palbociclib] which affects the activity of CASP7 protein
CTD PMID:22302033 PMID:24098593 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO palbociclib results in increased expression of CCN1 mRNA CTD PMID:22869556 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccna2 cyclin A2 decreases expression
multiple interactions
ISO palbociclib results in decreased expression of CCNA2 mRNA; palbociclib results in decreased expression of CCNA2 protein
E2F2 protein inhibits the reaction [palbociclib results in decreased expression of CCNA2 protein]; palbociclib inhibits the reaction [Doxorubicin results in increased expression of CCNA2 protein]; palbociclib inhibits the reaction [RBL1 protein binds to CCNA2 promoter]; palbociclib promotes the reaction [RB1 protein binds to CCNA2 promoter]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of CCNA2 protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to CCNA2 promoter]]; RB1 protein affects the reaction [palbociclib results in decreased expression of CCNA2 protein]
CTD PMID:20100483 PMID:20473330 PMID:21367843 PMID:21593195 PMID:22751436 More... NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO palbociclib results in decreased expression of CCNB1 mRNA CTD PMID:22869556 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO palbociclib results in decreased expression of CCNB2 mRNA CTD PMID:22869556 PMID:28620137 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Ccnd1 cyclin D1 decreases response to substance
multiple interactions
increases expression
ISO CCND1 gene results in decreased susceptibility to palbociclib
[CDKN2A gene mutant form results in increased expression of CCND1 protein] which results in increased susceptibility to palbociclib
palbociclib results in increased expression of CCND1 protein
[BMS 754807 co-treated with palbociclib] results in increased expression of CCND1 protein; Doxorubicin inhibits the reaction [palbociclib results in increased expression of CCND1 protein]; palbociclib inhibits the reaction [[CDK4 protein binds to CCND1 protein] which results in increased phosphorylation of SHOX2 protein]; palbociclib promotes the reaction [CCND1 protein binds to CDKN1B protein binds to CDK4 protein]; palbociclib promotes the reaction [CDK4 protein binds to CCND1 protein]
CTD PMID:20473330 PMID:21278246 PMID:22094256 PMID:22751436 PMID:22869556 More... NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd2 cyclin D2 multiple interactions ISO [CDKN2A gene mutant form results in increased expression of CCND2 protein] which results in increased susceptibility to palbociclib CTD PMID:24098593 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Ccnd3 cyclin D3 multiple interactions
increases expression
ISO palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of MEF2D protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RB1 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RBL2 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of SENP3 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of ZEB1 protein]
[CDKN2A gene mutant form results in increased expression of CCND3 protein] which results in increased susceptibility to palbociclib
palbociclib results in increased expression of CCND3 protein
CTD PMID:20473330 PMID:22094256 PMID:24098593 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccne1 cyclin E1 decreases response to substance
decreases expression
increases expression
ISO CCNE1 protein results in decreased susceptibility to palbociclib
palbociclib results in decreased expression of CCNE1 protein
palbociclib results in increased expression of CCNE1 protein
CTD PMID:17537993 PMID:21278246 PMID:21880723 PMID:23708653 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccne2 cyclin E2 decreases expression ISO palbociclib analog results in decreased expression of CCNE2 mRNA; palbociclib results in decreased expression of CCNE2 mRNA CTD PMID:15542782 PMID:22869556 PMID:26318986 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Ccnf cyclin F decreases expression ISO palbociclib results in decreased expression of CCNF mRNA CTD PMID:22869556 PMID:24606660 NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
JBrowse link
G Cdc20 cell division cycle 20 decreases expression ISO palbociclib results in decreased expression of CDC20 mRNA CTD PMID:22869556 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO palbociclib results in decreased expression of CDC25A mRNA CTD PMID:22869556 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO palbociclib results in decreased expression of CDC25C mRNA CTD PMID:22869556 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone multiple interactions ISO palbociclib inhibits the reaction [CDC37 protein binds to CDK4 protein]; palbociclib inhibits the reaction [CDC37 protein binds to CDK6 protein] CTD PMID:29091774 NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809
JBrowse link
G Cdc45 cell division cycle 45 decreases expression ISO palbociclib results in decreased expression of CDC45 mRNA CTD PMID:22869556 NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619
JBrowse link
G Cdca3 cell division cycle associated 3 decreases expression ISO palbociclib results in decreased expression of CDCA3 mRNA CTD PMID:22869556 NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799
JBrowse link
G Cdca5 cell division cycle associated 5 decreases expression ISO palbociclib results in decreased expression of CDCA5 mRNA CTD PMID:22869556 NCBI chr 1:203,378,550...203,392,027
Ensembl chr 1:203,378,577...203,392,023
JBrowse link
G Cdca8 cell division cycle associated 8 decreases expression ISO palbociclib results in decreased expression of CDCA8 mRNA CTD PMID:22869556 NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629
JBrowse link
G Cdh1 cadherin 1 affects localization
multiple interactions
ISO palbociclib affects the localization of CDH1 protein
CDH1 protein affects the reaction [palbociclib results in decreased expression of FOXM1 protein]
CTD PMID:22094256 PMID:22869556 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 multiple interactions
increases expression
ISO 2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of CDH2 protein] CTD PMID:22869556 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO palbociclib analog results in decreased expression of CDK1 mRNA; palbociclib results in decreased expression of CDK1 mRNA CTD PMID:15542782 PMID:22869556 PMID:24606660 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity
multiple interactions
decreases phosphorylation
decreases expression
ISO palbociclib results in decreased activity of CDK2 protein
palbociclib results in increased phosphorylation of and results in increased expression of CDK2 protein
palbociclib results in decreased phosphorylation of CDK2 protein
palbociclib results in decreased expression of CDK2 protein
CTD PMID:17537993 PMID:20100483 PMID:20473330 PMID:21880723 PMID:22869556 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases response to substance
decreases activity
multiple interactions
increases expression
increases response to substance
ISO CDK4 protein results in decreased susceptibility to palbociclib
palbociclib results in decreased activity of CDK4 protein
[CDKN2A gene mutant form results in increased expression of CDK4 protein] which results in increased susceptibility to palbociclib
palbociclib results in increased expression of CDK4 protein
palbociclib inhibits the reaction [[CDK4 protein binds to CCND1 protein] which results in increased phosphorylation of SHOX2 protein]; palbociclib inhibits the reaction [CDC37 protein binds to CDK4 protein]; palbociclib promotes the reaction [CCND1 protein binds to CDKN1B protein binds to CDK4 protein]; palbociclib promotes the reaction [CDK4 protein binds to CCND1 protein]
CDK4 protein results in increased susceptibility to palbociclib
CTD PMID:20473330 PMID:22094256 PMID:22711607 PMID:22761470 PMID:22869556 More... NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions
increases expression
ISO palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of MEF2D protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RB1 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RBL2 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of SENP3 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of ZEB1 protein]; palbociclib inhibits the reaction [CDC37 protein binds to CDK6 protein]
palbociclib results in increased expression of CDK6 protein
[CDKN2A gene mutant form results in increased expression of CDK6 protein] which results in increased susceptibility to palbociclib
CTD PMID:20473330 PMID:22094256 PMID:22869556 PMID:23138228 PMID:24098593 More... NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdk7 cyclin-dependent kinase 7 increases expression ISO palbociclib results in increased expression of CDK7 mRNA CTD PMID:24606660 NCBI chr 2:31,840,545...31,865,447
Ensembl chr 2:31,840,558...31,865,383
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO palbociclib results in increased expression of CDKN1A protein CTD PMID:20473330 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression
decreases expression
ISO palbociclib promotes the reaction [CCND1 protein binds to CDKN1B protein binds to CDK4 protein]
palbociclib results in increased expression of CDKN1B mRNA; palbociclib results in increased expression of CDKN1B protein
palbociclib results in decreased expression of CDKN1B protein
CTD PMID:17537993 PMID:20473330 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A affects response to substance
increases response to substance
multiple interactions
decreases response to substance
ISO CDKN2A gene modified form affects the susceptibility to palbociclib; CDKN2A gene mutant form affects the susceptibility to palbociclib; CDKN2A protein affects the susceptibility to palbociclib
CDKN2A gene mutant form results in increased susceptibility to palbociclib
[CDKN2A gene mutant form results in increased expression of CCND1 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased expression of CCND2 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased expression of CCND3 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased expression of CDK4 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased expression of CDK6 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased susceptibility to palbociclib] which affects the activity of CASP3 protein; [CDKN2A gene mutant form results in increased susceptibility to palbociclib] which affects the activity of CASP7 protein; [CDKN2A gene mutant form results in increased susceptibility to palbociclib] which results in decreased phosphorylation of RB1 protein
CDKN2A protein results in decreased susceptibility to palbociclib
[CDKN2A protein co-treated with CDKN2C protein] affects the susceptibility to palbociclib
CTD PMID:20534551 PMID:21278246 PMID:22711607 PMID:24098593 PMID:24495407 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression
multiple interactions
decreases response to substance
ISO palbociclib results in increased expression of CDKN2B protein
2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of CDKN2B protein]
CDKN2B protein results in decreased susceptibility to palbociclib
CTD PMID:22711607 PMID:22869556 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C multiple interactions ISO [CDKN2A protein co-treated with CDKN2C protein] affects the susceptibility to palbociclib CTD PMID:20534551 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO palbociclib results in decreased expression of CDKN3 mRNA CTD PMID:22869556 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 decreases expression ISO palbociclib results in decreased expression of CDT1 mRNA CTD PMID:22869556 NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659
JBrowse link
G Cenpa centromere protein A decreases expression ISO palbociclib results in decreased expression of CENPA mRNA CTD PMID:22869556 NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675
JBrowse link
G Cenpe centromere protein E decreases expression ISO palbociclib results in decreased expression of CENPE mRNA CTD PMID:22869556 NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
JBrowse link
G Cenpf centromere protein F decreases expression ISO palbociclib results in decreased expression of CENPF mRNA CTD PMID:22869556 NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669
JBrowse link
G Cenpm centromere protein M decreases expression ISO palbociclib results in decreased expression of CENPM mRNA CTD PMID:22869556 NCBI chr 7:113,748,026...113,759,296
Ensembl chr 7:113,747,516...113,764,258
JBrowse link
G Cep55 centrosomal protein 55 decreases expression ISO palbociclib results in decreased expression of CEP55 mRNA CTD PMID:22869556 NCBI chr 1:235,832,823...235,848,401
Ensembl chr 1:235,832,878...235,848,394
JBrowse link
G Ckap2l cytoskeleton associated protein 2-like decreases expression ISO palbociclib results in decreased expression of CKAP2L mRNA CTD PMID:22869556 NCBI chr 3:116,497,186...116,524,302
Ensembl chr 3:116,498,022...116,524,366
JBrowse link
G Cpa4 carboxypeptidase A4 increases expression ISO palbociclib results in increased expression of CPA4 mRNA CTD PMID:22869556 NCBI chr 4:59,188,284...59,212,255
Ensembl chr 4:59,188,284...59,212,255
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
ISO 2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of CTNNB1 protein] CTD PMID:22869556 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Dennd6b DENN domain containing 6B increases expression ISO palbociclib results in increased expression of DENND6B mRNA CTD PMID:22869556 NCBI chr 7:120,261,679...120,273,667
Ensembl chr 7:120,261,679...120,273,494
JBrowse link
G Depdc1b DEP domain containing 1B decreases expression ISO palbociclib results in decreased expression of DEPDC1B mRNA CTD PMID:22869556 NCBI chr 2:39,891,163...39,963,779
Ensembl chr 2:39,891,481...39,963,779
JBrowse link
G Dlgap5 DLG associated protein 5 decreases expression ISO palbociclib results in decreased expression of DLGAP5 mRNA CTD PMID:22869556 NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518
JBrowse link
G Donson DNA replication fork stabilization factor DONSON decreases expression ISO palbociclib results in decreased expression of DONSON mRNA CTD PMID:22869556 NCBI chr11:30,911,616...30,933,150
Ensembl chr11:30,923,239...30,932,889
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO palbociclib inhibits the reaction [Doxorubicin results in increased expression of E2F1 protein]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of E2F1 protein]] CTD PMID:22751436 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G E2f2 E2F transcription factor 2 multiple interactions
decreases expression
ISO E2F2 protein inhibits the reaction [palbociclib results in decreased expression of CCNA2 protein]; E2F2 protein inhibits the reaction [palbociclib results in decreased expression of RNR2 protein]; E2F2 protein inhibits the reaction [palbociclib results in decreased phosphorylation of RB1 protein]
palbociclib results in decreased expression of E2F2 mRNA
CTD PMID:20100483 PMID:20473330 PMID:22869556 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
JBrowse link
G Eln elastin increases expression ISO palbociclib results in increased expression of ELN protein CTD PMID:21880723 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
JBrowse link
G Exo1 exonuclease 1 decreases expression ISO palbociclib results in decreased expression of EXO1 mRNA CTD PMID:22869556 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit decreases expression ISO palbociclib results in decreased expression of EZH2 mRNA; palbociclib results in decreased expression of EZH2 protein CTD PMID:20948315 PMID:22869556 PMID:24736461 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO palbociclib results in increased expression of F3 mRNA CTD PMID:22869556 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fam111a FAM111 trypsin like peptidase A decreases expression ISO palbociclib results in decreased expression of FAM111A mRNA CTD PMID:22869556 NCBI chr 1:209,640,865...209,656,551
Ensembl chr 1:209,640,953...209,656,547
JBrowse link
G Fam83d family with sequence similarity 83, member D decreases expression ISO palbociclib results in decreased expression of FAM83D mRNA CTD PMID:22869556 NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192
JBrowse link
G Fance FA complementation group E decreases expression ISO palbociclib results in decreased expression of FANCE mRNA CTD PMID:28620137 NCBI chr20:6,369,416...6,386,631
Ensembl chr20:6,375,573...6,386,631
JBrowse link
G Fanci FA complementation group I decreases expression ISO palbociclib results in decreased expression of FANCI mRNA CTD PMID:22869556 NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640
JBrowse link
G Fbxo5 F-box protein 5 decreases expression ISO palbociclib results in decreased expression of FBXO5 mRNA CTD PMID:22869556 NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437
JBrowse link
G Fen1 flap structure-specific endonuclease 1 decreases expression ISO palbociclib results in decreased expression of FEN1 mRNA CTD PMID:22869556 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases expression
affects response to substance
decreases phosphorylation
multiple interactions
ISO palbociclib results in decreased expression of FLT3 mRNA; palbociclib results in decreased expression of FLT3 protein
FLT3 protein affects the susceptibility to palbociclib
palbociclib results in decreased phosphorylation of FLT3 protein
[FLT3 protein affects the susceptibility to palbociclib] which results in decreased expression of FLT3 protein
CTD PMID:27099147 NCBI chr12:7,623,658...7,699,474
Ensembl chr12:7,623,930...7,699,474
JBrowse link
G Foxm1 forkhead box M1 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [palbociclib results in decreased expression of FOXM1 protein]; CDH1 protein affects the reaction [palbociclib results in decreased expression of FOXM1 protein]; palbociclib results in decreased expression of and results in decreased activity of FOXM1 protein
palbociclib results in decreased expression of FOXM1 mRNA
CTD PMID:22094256 PMID:22869556 NCBI chr 4:161,639,561...161,652,012
Ensembl chr 4:161,638,816...161,650,684
JBrowse link
G Gins2 GINS complex subunit 2 decreases expression ISO palbociclib results in decreased expression of GINS2 mRNA CTD PMID:22869556 NCBI chr19:48,626,770...48,639,523
Ensembl chr19:48,626,770...48,639,339
JBrowse link
G Gls glutaminase increases expression ISO palbociclib results in increased expression of GLS mRNA CTD PMID:28620137 NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900
JBrowse link
G Gmnn geminin, DNA replication inhibitor decreases expression ISO palbociclib results in decreased expression of GMNN mRNA CTD PMID:22869556 NCBI chr17:40,301,771...40,310,054
Ensembl chr17:40,301,808...40,310,054
JBrowse link
G Gpsm2 G-protein signaling modulator 2 decreases expression ISO palbociclib results in decreased expression of GPSM2 mRNA CTD PMID:22869556 NCBI chr 2:196,327,149...196,375,322
Ensembl chr 2:196,327,149...196,375,154
JBrowse link
G Gpt glutamic--pyruvic transaminase increases secretion ISO palbociclib results in increased secretion of GPT protein CTD PMID:29655783 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G H2ax H2A.X variant histone multiple interactions
decreases phosphorylation
ISO Doxorubicin inhibits the reaction [palbociclib results in decreased phosphorylation of H2AX protein]; palbociclib inhibits the reaction [Camptothecin results in increased expression of H2AX protein]; palbociclib inhibits the reaction [Carboplatin results in increased expression of H2AX protein]; palbociclib inhibits the reaction [Doxorubicin results in increased expression of H2AX protein]; palbociclib inhibits the reaction [Etoposide results in increased expression of H2AX protein]; palbociclib inhibits the reaction [Paclitaxel results in increased expression of H2AX protein]; RB1 protein affects the reaction [palbociclib results in decreased phosphorylation of H2AX protein] CTD PMID:22302033 PMID:22751436 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G H4c3 H4 clustered histone 3 decreases expression ISO palbociclib results in decreased expression of H4C3 mRNA CTD PMID:22869556
G Hjurp Holliday junction recognition protein decreases expression ISO palbociclib results in decreased expression of HJURP mRNA CTD PMID:22869556 NCBI chr 9:88,853,379...88,867,730
Ensembl chr 9:88,853,386...88,867,728
JBrowse link
G Hmgb2 high mobility group box 2 decreases expression ISO palbociclib results in decreased expression of HMGB2 mRNA CTD PMID:22869556 NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
JBrowse link
G Hmmr hyaluronan-mediated motility receptor decreases expression ISO palbociclib results in decreased expression of HMMR mRNA CTD PMID:22869556 NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO [BMS 754807 co-treated with palbociclib] results in decreased phosphorylation of IGF1R protein CTD PMID:24986516 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Il20rb interleukin 20 receptor subunit beta increases expression ISO palbociclib results in increased expression of IL20RB mRNA CTD PMID:22869556 NCBI chr 8:100,979,085...101,010,829
Ensembl chr 8:100,980,383...101,009,942
JBrowse link
G Incenp inner centromere protein decreases expression ISO palbociclib results in decreased expression of INCENP mRNA CTD PMID:22869556 NCBI chr 1:206,520,655...206,550,575
Ensembl chr 1:206,523,380...206,553,265
JBrowse link
G Kif11 kinesin family member 11 decreases expression ISO palbociclib results in decreased expression of KIF11 mRNA CTD PMID:22869556 NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
JBrowse link
G Kif14 kinesin family member 14 decreases expression ISO palbociclib results in decreased expression of KIF14 mRNA CTD PMID:22869556 NCBI chr13:47,926,975...47,990,598
Ensembl chr13:47,927,044...47,989,164
JBrowse link
G Kif15 kinesin family member 15 decreases expression ISO palbociclib results in decreased expression of KIF15 mRNA CTD PMID:22869556 NCBI chr 8:122,601,888...122,672,750
Ensembl chr 8:122,601,897...122,672,750
JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO palbociclib results in decreased expression of KIF20A mRNA CTD PMID:22869556 NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780
JBrowse link
G Kif23 kinesin family member 23 decreases expression ISO palbociclib results in decreased expression of KIF23 mRNA CTD PMID:22869556 NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072
JBrowse link
G Kif2c kinesin family member 2C decreases expression ISO palbociclib results in decreased expression of KIF2C mRNA CTD PMID:22869556 NCBI chr 5:130,637,347...130,662,680
Ensembl chr 5:130,637,347...130,662,637
JBrowse link
G Kif4a kinesin family member 4A decreases expression ISO palbociclib results in decreased expression of KIF4A mRNA CTD PMID:22869556 NCBI chr  X:65,721,724...65,824,151
Ensembl chr  X:65,721,779...65,824,139
JBrowse link
G Kifc1 kinesin family member C1 decreases expression ISO palbociclib results in decreased expression of KIFC1 mRNA CTD PMID:22869556 NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105
JBrowse link
G Knstrn kinetochore-localized astrin/SPAG5 binding protein decreases expression ISO palbociclib results in decreased expression of KNSTRN mRNA CTD PMID:22869556 NCBI chr 3:105,800,762...105,820,555
Ensembl chr 3:105,800,954...105,820,715
JBrowse link
G Kpna2 karyopherin subunit alpha 2 decreases expression ISO palbociclib results in decreased expression of KPNA2 mRNA CTD PMID:22869556 NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150
JBrowse link
G Lama3 laminin subunit alpha 3 increases expression ISO palbociclib results in increased expression of LAMA3 mRNA CTD PMID:22869556 NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353
JBrowse link
G Lamb3 laminin subunit beta 3 increases expression ISO palbociclib results in increased expression of LAMB3 mRNA CTD PMID:22869556 NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405
JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression ISO palbociclib results in increased expression of LAMC2 mRNA CTD PMID:22869556 NCBI chr13:65,284,664...65,344,200
Ensembl chr13:65,284,664...65,344,200
JBrowse link
G Lmnb1 lamin B1 decreases expression ISO palbociclib results in decreased expression of LMNB1 mRNA CTD PMID:22869556 NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502
JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor decreases expression ISO palbociclib results in decreased expression of MCM10 mRNA CTD PMID:22869556 NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 multiple interactions
decreases expression
ISO RB1 protein affects the reaction [palbociclib results in decreased expression of MCM7 protein]
palbociclib results in decreased expression of MCM7 mRNA; palbociclib results in decreased expression of MCM7 protein
CTD PMID:20473330 PMID:22869556 NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063
JBrowse link
G Mef2d myocyte enhancer factor 2D multiple interactions ISO palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of MEF2D protein] CTD PMID:22094256 NCBI chr 2:173,606,054...173,635,620
Ensembl chr 2:173,606,490...173,634,457
JBrowse link
G Melk maternal embryonic leucine zipper kinase decreases expression ISO palbociclib results in decreased expression of MELK mRNA CTD PMID:22869556 NCBI chr 5:58,540,393...58,600,937
Ensembl chr 5:58,540,449...58,600,937
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
decreases expression
ISO Doxorubicin promotes the reaction [palbociclib results in decreased expression of MKI67 protein]; RB1 protein affects the reaction [palbociclib results in decreased expression of MKI67 protein] CTD PMID:15542782 PMID:22170262 PMID:22383795 PMID:22751436 PMID:23708653 More... NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mxd4 Max dimerization protein 4 increases expression ISO palbociclib results in increased expression of MXD4 mRNA CTD PMID:22869556 NCBI chr14:76,562,105...76,576,224
Ensembl chr14:76,561,774...76,576,221
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO palbociclib results in decreased expression of MYC protein CTD PMID:27099147 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Ncapd2 non-SMC condensin I complex, subunit D2 decreases expression ISO palbociclib results in decreased expression of NCAPD2 mRNA CTD PMID:22869556 NCBI chr 4:157,968,814...157,992,314
Ensembl chr 4:157,968,815...157,992,020
JBrowse link
G Ncapg non-SMC condensin I complex, subunit G decreases expression ISO palbociclib results in decreased expression of NCAPG mRNA CTD PMID:22869556 NCBI chr14:65,404,235...65,432,902
Ensembl chr14:65,404,163...65,432,902
JBrowse link
G Ncapg2 non-SMC condensin II complex, subunit G2 decreases expression ISO palbociclib results in decreased expression of NCAPG2 mRNA CTD PMID:22869556 NCBI chr 6:137,342,449...137,418,083
Ensembl chr 6:137,342,943...137,415,159
JBrowse link
G Ndc80 NDC80 kinetochore complex component decreases expression ISO palbociclib results in decreased expression of NDC80 mRNA CTD PMID:22869556 NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924
JBrowse link
G Nek2 NIMA-related kinase 2 decreases expression ISO palbociclib results in decreased expression of NEK2 mRNA CTD PMID:22869556 NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051
JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 decreases expression ISO palbociclib results in decreased expression of NUSAP1 mRNA CTD PMID:22869556 NCBI chr 3:106,603,273...106,633,624
Ensembl chr 3:106,603,289...106,633,624
JBrowse link
G Oip5 Opa interacting protein 5 decreases expression ISO palbociclib results in decreased expression of OIP5 mRNA CTD PMID:22869556 NCBI chr 3:106,593,746...106,603,281
Ensembl chr 3:106,593,760...106,603,250
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [palbociclib results in increased susceptibility to idelalisib] which results in increased cleavage of PARP1 protein; palbociclib inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]] CTD PMID:22751436 PMID:23676220 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pbk PDZ binding kinase decreases expression ISO palbociclib results in decreased expression of PBK mRNA CTD PMID:22869556 NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014
JBrowse link
G Pclaf PCNA clamp associated factor decreases expression ISO palbociclib results in decreased expression of PCLAF mRNA CTD PMID:22869556 NCBI chr 8:66,420,673...66,432,568
Ensembl chr 8:66,420,587...66,432,994
Ensembl chr 8:66,420,587...66,432,994
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO palbociclib results in decreased expression of PCNA mRNA; palbociclib results in decreased expression of PCNA protein CTD PMID:20473330 PMID:22869556 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO palbociclib inhibits the reaction [[PDGFB protein binds to PDGFB protein] inhibits the reaction [RB1 protein binds to SP1 protein]] CTD PMID:21880723 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Phf19 PHD finger protein 19 decreases expression ISO palbociclib results in decreased expression of PHF19 mRNA CTD PMID:22869556 NCBI chr 3:18,175,281...18,197,289
Ensembl chr 3:18,175,282...18,196,405
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase decreases expression ISO palbociclib results in decreased expression of PIM1 mRNA CTD PMID:27099147 NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174
JBrowse link
G Pimreg PICALM interacting mitotic regulator decreases expression ISO palbociclib results in decreased expression of PIMREG mRNA CTD PMID:22869556 NCBI chr10:56,669,603...56,674,540
Ensembl chr10:56,669,675...56,674,791
JBrowse link
G Plk1 polo-like kinase 1 decreases expression
multiple interactions
ISO palbociclib results in decreased expression of PLK1 mRNA
palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]]
CTD PMID:20100483 PMID:22869556 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Pola2 DNA polymerase alpha 2, accessory subunit decreases expression ISO palbociclib results in decreased expression of POLA2 mRNA CTD PMID:22869556 NCBI chr 1:203,227,183...203,251,350
Ensembl chr 1:203,203,388...203,251,348
JBrowse link
G Pole2 DNA polymerase epsilon 2, accessory subunit decreases expression ISO palbociclib results in decreased expression of POLE2 mRNA CTD PMID:22869556 NCBI chr 6:87,674,702...87,712,723
Ensembl chr 6:87,674,702...87,699,305
JBrowse link
G Porcn porcupine O-acyltransferase increases expression ISO palbociclib results in increased expression of PORCN mRNA CTD PMID:22869556 NCBI chr  X:14,285,864...14,298,481
Ensembl chr  X:14,285,871...14,298,481
JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO palbociclib results in decreased expression of PRC1 mRNA CTD PMID:22869556 NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
JBrowse link
G Prim1 DNA primase subunit 1 decreases expression ISO palbociclib results in decreased expression of PRIM1 mRNA CTD PMID:22869556 NCBI chr 7:446,342...462,526
Ensembl chr 7:431,805...462,526
JBrowse link
G Prr11 proline rich 11 decreases expression ISO palbociclib results in decreased expression of PRR11 mRNA CTD PMID:22869556 NCBI chr10:71,898,858...71,943,325
Ensembl chr10:71,901,202...71,921,012
JBrowse link
G Prss23 serine protease 23 increases expression ISO palbociclib results in increased expression of PRSS23 mRNA CTD PMID:22869556 NCBI chr 1:143,402,725...143,422,182
Ensembl chr 1:143,401,396...143,422,091
JBrowse link
G Psrc1 proline and serine rich coiled-coil 1 decreases expression ISO palbociclib results in decreased expression of PSRC1 mRNA CTD PMID:22869556 NCBI chr 2:196,022,361...196,026,874
Ensembl chr 2:196,022,361...196,026,874
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin decreases expression ISO palbociclib results in decreased expression of PTTG1 mRNA CTD PMID:22869556 PMID:28620137 NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
JBrowse link
G Racgap1 Rac GTPase-activating protein 1 decreases expression ISO palbociclib results in decreased expression of RACGAP1 mRNA CTD PMID:22869556 NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831
JBrowse link
G Rad51ap1 RAD51 associated protein 1 decreases expression ISO palbociclib results in decreased expression of RAD51AP1 mRNA CTD PMID:22869556 NCBI chr 4:159,759,454...159,772,524
Ensembl chr 4:159,759,459...159,772,524
JBrowse link
G Ranbp1 RAN binding protein 1 decreases expression ISO palbociclib results in decreased expression of RANBP1 mRNA CTD PMID:28620137 NCBI chr11:82,742,603...82,750,836
Ensembl chr11:82,742,600...82,750,838
JBrowse link
G Rb1 RB transcriptional corepressor 1 affects phosphorylation
decreases expression
increases response to substance
multiple interactions
affects response to substance
decreases response to substance
affects reaction
increases phosphorylation
decreases phosphorylation
ISO palbociclib affects the phosphorylation of RB1 protein
palbociclib results in decreased expression of RB1 mRNA; palbociclib results in decreased expression of RB1 protein
RB1 protein results in increased susceptibility to palbociclib
[CDKN2A gene mutant form results in increased susceptibility to palbociclib] which results in decreased phosphorylation of RB1 protein
RB1 protein affects the susceptibility to palbociclib
BMS 754807 promotes the reaction [palbociclib results in decreased phosphorylation of RB1 protein]; E2F2 protein inhibits the reaction [palbociclib results in decreased phosphorylation of RB1 protein]; palbociclib affects the reaction [RB1 mutant form results in increased expression of RBL2 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RB1 protein]; palbociclib inhibits the reaction [[PDGFB protein binds to PDGFB protein] inhibits the reaction [RB1 protein binds to SP1 protein]]; palbociclib inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased phosphorylation of RB1 protein]; palbociclib promotes the reaction [RB1 protein binds to CCNA2 promoter]; palbociclib promotes the reaction [RB1 protein binds to SP1 protein]; palbociclib results in decreased phosphorylation of and results in decreased expression of RB1 protein; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of CCNA2 protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of E2F1 protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to CCNA2 promoter]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to RNR2 promoter]]; RB1 protein affects the reaction [palbociclib promotes the reaction [Cycloheximide results in decreased expression of RBL1 protein]]; RB1 protein affects the reaction [palbociclib results in decreased expression of CCNA2 protein]; RB1 protein affects the reaction [palbociclib results in decreased expression of MCM7 protein]; RB1 protein affects the reaction [palbociclib results in decreased expression of MKI67 protein]; RB1 protein affects the reaction [palbociclib results in decreased expression of RBL1 protein]; RB1 protein affects the reaction [palbociclib results in decreased phosphorylation of H2AX protein]; RB1 protein affects the reaction [palbociclib results in decreased phosphorylation of RB1 protein]
RB1 gene mutant form results in decreased susceptibility to palbociclib; RB1 mutant form results in decreased susceptibility to palbociclib
RB1 protein affects the reaction palbociclib
palbociclib results in increased phosphorylation of RB1 protein
CTD PMID:15542782 PMID:16690963 PMID:17537993 PMID:19435910 PMID:19874578 More... NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [palbociclib results in decreased expression of RBL1 protein]; palbociclib inhibits the reaction [RBL1 protein binds to CCNA2 promoter]; palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]; palbociclib inhibits the reaction [RBL1 protein binds to RNR2 promoter]; palbociclib promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of RBL1 protein]; palbociclib promotes the reaction [Cycloheximide results in decreased expression of RBL1 protein]; palbociclib results in decreased phosphorylation of and results in decreased expression of RBL1 protein; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to CCNA2 promoter]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to RNR2 promoter]]; RB1 protein affects the reaction [palbociclib promotes the reaction [Cycloheximide results in decreased expression of RBL1 protein]]; RB1 protein affects the reaction [palbociclib results in decreased expression of RBL1 protein]
palbociclib results in decreased expression of RBL1 mRNA; palbociclib results in decreased expression of RBL1 protein
CTD PMID:20100483 PMID:20473330 NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 multiple interactions
decreases phosphorylation
ISO palbociclib affects the reaction [RB1 mutant form results in increased expression of RBL2 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RBL2 protein]; palbociclib results in decreased phosphorylation of and results in increased expression of RBL2 protein; palbociclib results in increased expression of and results in increased stability of RBL2 protein
palbociclib results in decreased phosphorylation of RBL2 protein
CTD PMID:20100483 PMID:20473330 PMID:22094256 PMID:26174628 NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
JBrowse link
G Rdh5 retinol dehydrogenase 5 increases expression ISO palbociclib results in increased expression of RDH5 mRNA CTD PMID:22869556 NCBI chr 7:1,340,545...1,347,361 JBrowse link
G Rfc5 replication factor C subunit 5 decreases expression ISO palbociclib results in decreased expression of RFC5 mRNA CTD PMID:22869556 NCBI chr12:39,207,484...39,217,041
Ensembl chr12:39,207,484...39,217,312
JBrowse link
G Rps29 ribosomal protein S29 increases expression ISO palbociclib results in increased expression of RPS29 mRNA CTD PMID:22869556 NCBI chr 6:87,635,229...87,636,605
Ensembl chr 6:87,635,230...87,636,636
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO palbociclib promotes the reaction [BMS 754807 results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:24986516 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 decreases expression ISO palbociclib results in decreased expression of RRM1 mRNA CTD PMID:22869556 NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO palbociclib results in decreased expression of RRM2 mRNA CTD PMID:22869556 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
JBrowse link
G Sapcd2 suppressor APC domain containing 2 decreases expression ISO palbociclib results in decreased expression of SAPCD2 mRNA CTD PMID:22869556 NCBI chr 3:8,186,089...8,195,119
Ensembl chr 3:8,187,266...8,192,546
JBrowse link
G Senp3 SUMO specific peptidase 3 multiple interactions ISO palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of SENP3 protein] CTD PMID:22094256 NCBI chr10:54,390,698...54,399,590
Ensembl chr10:54,390,694...54,399,593
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO palbociclib results in increased expression of SERPINE1 mRNA CTD PMID:22869556 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Shox2 short stature homeobox 2 multiple interactions ISO palbociclib inhibits the reaction [[CDK4 protein binds to CCND1 protein] which results in increased phosphorylation of SHOX2 protein] CTD PMID:22094256 NCBI chr 2:151,217,049...151,227,180
Ensembl chr 2:151,217,552...151,227,143
JBrowse link
G Slc16a4 solute carrier family 16, member 4 increases expression ISO palbociclib results in increased expression of SLC16A4 mRNA CTD PMID:22869556 NCBI chr 2:194,911,075...194,933,162
Ensembl chr 2:194,911,236...194,933,117
JBrowse link
G Smc4 structural maintenance of chromosomes 4 decreases expression ISO palbociclib results in decreased expression of SMC4 mRNA CTD PMID:22869556 NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571
JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions
increases expression
ISO 2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of SNAI2 protein] CTD PMID:22869556 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO palbociclib inhibits the reaction [[PDGFB protein binds to PDGFB protein] inhibits the reaction [RB1 protein binds to SP1 protein]]; palbociclib promotes the reaction [RB1 protein binds to SP1 protein] CTD PMID:21880723 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Sparc secreted protein acidic and cysteine rich increases expression ISO palbociclib results in increased expression of SPARC mRNA CTD PMID:28620137 NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
JBrowse link
G Spc24 SPC24 component of NDC80 kinetochore complex decreases expression ISO palbociclib results in decreased expression of SPC24 mRNA CTD PMID:22869556 NCBI chr 8:20,300,315...20,305,354
Ensembl chr 8:20,300,319...20,305,310
JBrowse link
G Spc25 SPC25 component of NDC80 kinetochore complex decreases expression ISO palbociclib results in decreased expression of SPC25 mRNA CTD PMID:22869556 NCBI chr 3:53,930,013...53,988,940
Ensembl chr 3:53,975,704...53,988,959
JBrowse link
G Stil STIL, centriolar assembly protein decreases expression ISO palbociclib results in decreased expression of STIL mRNA CTD PMID:22869556 NCBI chr 5:128,520,837...128,573,732
Ensembl chr 5:128,520,953...128,573,730
JBrowse link
G Stmn1 stathmin 1 decreases expression ISO palbociclib results in decreased expression of STMN1 mRNA CTD PMID:22869556 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link
G Tacc3 transforming, acidic coiled-coil containing protein 3 decreases expression ISO palbociclib results in decreased expression of TACC3 mRNA CTD PMID:28620137 NCBI chr14:77,051,209...77,065,343
Ensembl chr14:77,051,215...77,065,219
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases activity ISO palbociclib results in increased activity of TGFB1 protein CTD PMID:22869556 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tk1 thymidine kinase 1 decreases expression ISO palbociclib analog results in decreased expression of TK1 mRNA; palbociclib results in decreased expression of TK1 mRNA; palbociclib results in decreased expression of TK1 protein CTD PMID:15542782 PMID:22170262 PMID:22869556 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
JBrowse link
G Tmpo thymopoietin decreases expression ISO palbociclib results in decreased expression of TMPO mRNA CTD PMID:22869556 NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727
JBrowse link
G Tmprss2 transmembrane serine protease 2 multiple interactions ISO palbociclib promotes the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA] CTD PMID:23708653 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link
G Top1 DNA topoisomerase I decreases expression ISO palbociclib results in decreased expression of TOP1 mRNA CTD PMID:24549232 NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression
multiple interactions
ISO palbociclib analog results in decreased expression of TOP2A mRNA; palbociclib results in decreased expression of TOP2A mRNA; palbociclib results in decreased expression of TOP2A protein
palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein]]
CTD PMID:15542782 PMID:20948315 PMID:22751436 PMID:22869556 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Tp53 tumor protein p53 decreases response to substance ISO TP53 protein mutant form results in decreased susceptibility to palbociclib CTD PMID:21278246 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpx2 TPX2, microtubule nucleation factor decreases expression ISO palbociclib results in decreased expression of TPX2 mRNA CTD PMID:22869556 NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468
JBrowse link
G Troap trophinin associated protein decreases expression ISO palbociclib results in decreased expression of TROAP mRNA CTD PMID:22869556 NCBI chr 7:130,233,534...130,242,369
Ensembl chr 7:130,234,544...130,242,365
JBrowse link
G Ttc14 tetratricopeptide repeat domain 14 increases expression ISO palbociclib results in increased expression of TTC14 mRNA CTD PMID:22869556 NCBI chr 2:116,653,543...116,665,072
Ensembl chr 2:116,653,595...116,664,158
JBrowse link
G Ttk Ttk protein kinase decreases expression ISO palbociclib results in decreased expression of TTK mRNA CTD PMID:22869556 NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651
JBrowse link
G Tubb4b tubulin, beta 4B class IVb decreases expression ISO palbociclib results in decreased expression of TUBB4B mRNA CTD PMID:22869556 NCBI chr 3:8,037,844...8,040,294
Ensembl chr 3:8,037,799...8,040,296
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO palbociclib results in decreased expression of TUBB mRNA CTD PMID:22869556 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
JBrowse link
G Tyms thymidylate synthetase decreases expression ISO palbociclib results in decreased expression of TYMS mRNA; palbociclib results in decreased expression of TYMS protein CTD PMID:20948315 PMID:22869556 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO palbociclib results in decreased expression of UBE2C mRNA CTD PMID:22869556 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
JBrowse link
G Ube2t ubiquitin-conjugating enzyme E2T decreases expression ISO palbociclib results in decreased expression of UBE2T mRNA CTD PMID:22869556 NCBI chr13:46,403,352...46,413,854
Ensembl chr13:46,403,375...46,414,835
JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 decreases expression ISO palbociclib results in decreased expression of UHRF1 mRNA CTD PMID:22869556 NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631
JBrowse link
G Vim vimentin increases expression ISO palbociclib results in increased expression of VIM protein CTD PMID:22869556 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 multiple interactions ISO palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of ZEB1 protein] CTD PMID:22094256 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
JBrowse link
G Zwint ZW10 interacting kinetochore protein decreases expression ISO palbociclib results in decreased expression of ZWINT mRNA CTD PMID:22869556 NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957
JBrowse link
phenazopyridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Phenazopyridine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Utrn utrophin increases expression ISO Phenazopyridine results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313
JBrowse link
picloram term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxo1 forkhead box O1 decreases expression
multiple interactions
ISO Picloram results in decreased expression of FOXO1 mRNA
arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Picloram results in decreased expression of FOXO1 mRNA]
CTD PMID:21318024 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression
multiple interactions
ISO Picloram results in decreased expression of GRIN1 mRNA
arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Picloram results in decreased expression of GRIN1 mRNA]
CTD PMID:21318024 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 multiple interactions
decreases expression
ISO arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Picloram results in decreased expression of ATP6 mRNA] CTD PMID:21318024 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I decreases expression
multiple interactions
ISO Picloram results in decreased expression of COX1 mRNA
arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Picloram results in decreased expression of COX1 mRNA]
CTD PMID:21318024 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b multiple interactions
decreases expression
ISO arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Picloram results in decreased expression of CYTB mRNA] CTD PMID:21318024 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 multiple interactions
decreases expression
ISO arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Picloram results in decreased expression of ND1 mRNA] CTD PMID:21318024 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Picloram results in increased expression of PPARGC1A mRNA CTD PMID:21318024 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions
decreases expression
ISO arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Picloram results in decreased expression of PRDX1 mRNA] CTD PMID:21318024 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856
JBrowse link
G Prdx2 peroxiredoxin 2 multiple interactions
decreases expression
ISO arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Picloram results in decreased expression of PRDX2 mRNA] CTD PMID:21318024 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions
decreases expression
ISO arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Picloram results in decreased expression of PRDX3 mRNA] CTD PMID:21318024 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111
JBrowse link
G Prdx4 peroxiredoxin 4 multiple interactions
decreases expression
ISO arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Picloram results in decreased expression of PRDX4 mRNA] CTD PMID:21318024 NCBI chr  X:40,026,762...40,044,066
Ensembl chr  X:40,026,651...40,044,066
JBrowse link
G Prdx5 peroxiredoxin 5 decreases expression
multiple interactions
ISO Picloram results in decreased expression of PRDX5 mRNA
arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Picloram results in decreased expression of PRDX5 mRNA]
CTD PMID:21318024 NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268
JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions
decreases expression
ISO arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Picloram results in decreased expression of PRDX6 mRNA] CTD PMID:21318024 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355
JBrowse link
rosiglitazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipor2 adiponectin receptor 2 increases expression
affects expression
EXP rosiglitazone increases expression of adipor2 protein in liver of OLETF rats
rosiglitazone affects expression of adipor2 mRNA and protein in NASH (rat) liver, visceral fat, and skeletal muscle
RGD PMID:30225267 PMID:20965162 RGD:21406435, RGD:25440494 NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
JBrowse link
G Fn1 fibronectin 1 decreases expression EXP rosiglitazone decreases expression of fibronectin mRNA in liver in porcine serum induced model of cirrhosis in rat RGD PMID:15980055 RGD:1625201 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
sonidegib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli1 GLI family zinc finger 1 decreases expression ISO sonidegib results in decreased expression of GLI1 mRNA CTD PMID:24973920 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
JBrowse link
G Gli2 GLI family zinc finger 2 decreases expression
decreases response to substance
multiple interactions
ISO sonidegib results in decreased expression of GLI2 mRNA
GLI2 protein results in decreased susceptibility to sonidegib
sonidegib inhibits the reaction [SUFU gene mutant form results in increased expression of GLI2 mRNA]
CTD PMID:24973920 NCBI chr13:29,946,809...30,163,901
Ensembl chr13:29,946,809...30,163,574
JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation EXP sonidegib results in increased phosphorylation of MTOR protein CTD PMID:31568847 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor decreases response to substance ISO MYCN protein results in decreased susceptibility to sonidegib CTD PMID:24973920 NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590
JBrowse link
G Smo smoothened, frizzled class receptor decreases response to substance ISO SMO protein mutant form results in decreased susceptibility to sonidegib CTD PMID:24973920 NCBI chr 4:58,344,101...58,372,828
Ensembl chr 4:58,343,529...58,373,829
JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling multiple interactions
decreases response to substance
ISO sonidegib inhibits the reaction [SUFU gene mutant form results in increased expression of GLI2 mRNA]
SUFU gene mutant form results in decreased susceptibility to sonidegib
CTD PMID:24973920 NCBI chr 1:245,257,725...245,355,576
Ensembl chr 1:245,257,768...245,355,577
JBrowse link
torasemide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases expression EXP Torsemide results in increased expression of AGT protein modified form CTD PMID:18154949 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 affects expression EXP Torsemide affects the expression of CYP11B2 protein CTD PMID:18001696 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 affects metabolic processing EXP CYP2C11 protein affects the metabolism of Torsemide CTD PMID:15890479 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing
multiple interactions
ISO CYP2C8 protein results in increased metabolism of Torsemide
Torsemide inhibits the reaction [Amiodarone results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Fluoxetine results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Isoniazid results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Nortriptyline results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Phenelzine results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Verapamil results in decreased activity of CYP2C8 protein]
CTD PMID:15304522
G Nppa natriuretic peptide A decreases expression EXP Torsemide results in decreased expression of NPPA protein CTD PMID:18154949 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions EXP Torsemide inhibits the reaction [Aldosterone binds to NR3C2 protein] CTD PMID:7954537 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Ren renin increases expression EXP Torsemide results in increased expression of REN protein CTD PMID:7954537 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Slc12a2 solute carrier family 12 member 2 decreases activity
multiple interactions
ISO Torsemide results in decreased activity of SLC12A2 protein
Torsemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]
CTD PMID:29959396 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
affects expression
EXP Torsemide results in decreased expression of TGFB1 protein
Torsemide affects the expression of TGFB1 protein
CTD PMID:18001696 PMID:18154949 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19759
      application 19468
        refrigerant 17691
          ammonia 17279
            organic amino compound 17279
              aromatic amine 13702
                aminopyridine 366
                  (8aS)-7-[(6-chloronaphthalen-2-yl)sulfonyl]-8a-(methoxymethyl)-1'-pyridin-4-yltetrahydro-5H-spiro[1,3-oxazolo[3,2-a]pyrazine-2,4'-piperidin]-5-one 0
                  1-(2-\{[(6-amino-2-methylpyridin-3-yl)methyl]amino\}ethyl)-6-chloro-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-1,4-dihydropyrazin-2-ol 0
                  1-(3-aminopropyl)-3-[3-[(5-bromo-2-pyridinyl)-[(4-chlorophenyl)methyl]amino]propyl]thiourea 0
                  1-[3-[(5-bromo-2-pyridinyl)-(phenylmethyl)amino]propyl]-3-[3-(1H-imidazol-5-yl)propyl]thiourea 0
                  1-[3-[(5-bromo-2-pyridinyl)-[(3,4-dichlorophenyl)methyl]amino]propyl]-3-[3-(1H-imidazol-5-yl)propyl]thiourea 0
                  1-[3-[(5-bromo-2-pyridinyl)-[(4-chlorophenyl)methyl]amino]propyl]-3-[3-(1H-imidazol-5-yl)propyl]thiourea 0
                  1-[4-[(5-bromo-2-pyridinyl)-[(4-chlorophenyl)methyl]amino]butyl]-3-[3-(1H-imidazol-5-yl)propyl]thiourea 0
                  1-acetyl-4-(4-\{4-[(2-ethoxyphenyl)thio]-3-nitrophenyl\}pyridin-2-yl)piperazine 0
                  1-butyl-3-(2-hydroxyethylamino)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile 0
                  2-(4-morpholinyl)-N-[1-(phenylmethyl)-2,3-dihydropyrrolo[2,3-b]quinolin-4-yl]acetamide 0
                  2-(6-methoxy-1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-[4-(piperazin-1-yl)pyridin-3-yl]-1,3-thiazole-4-carboxamide 0
                  2-[(3-pyridinylamino)methylidene]propanedinitrile 0
                  2-[[(5-chloro-2-pyridinyl)amino]methylidene]-1-cyclohexanone 0
                  2-aminonicotinic acid 0
                  3-(5-chloro-1,3-benzoxazol-2-yl)-N-(phenylmethyl)-2-pyridinamine 0
                  3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine + 55
                  3-amino-4-iodopyridine 0
                  4'-hydroxy torasemide 0
                  4-Amino-2-chloropyridine 0
                  4-METHYLPYRIDIN-2-AMINE 0
                  4-aminonicotinic acid 0
                  4-aminopyridine + 41
                  4-aminopyridine-3-methanol 0
                  4-phenyl-N-(3-pyridinyl)-2-thiazolamine 0
                  5-[(2-pyridinylamino)methyl]-8-quinolinol 0
                  5-[4-(dimethylamino)phenyl]-6-[(6-morpholin-4-ylpyridin-3-yl)ethynyl]pyrimidin-4-amine 0
                  5-aminonicotinic acid 0
                  5-nitro-N-[(4-propan-2-ylphenyl)methyl]-2-pyridinamine 0
                  6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7(8H)-one 0
                  6-aminonicotinamide 14
                  6-aminonicotinic acid + 14
                  7-ethyl-1-[(phenylmethyl)amino]-3-(1-piperidinyl)-6,8-dihydro-5H-2,7-naphthyridine-4-carbonitrile 0
                  BAY 60-6583 5
                  BKM120 0
                  CHIR 99021 71
                  GSK343 2
                  LSM-24360 0
                  LSM-24662 0
                  N'-[(4-chlorophenyl)methyl]-N,N-dimethyl-N'-(2-pyridinyl)ethane-1,2-diamine 0
                  N,4-bis(3-pyridinyl)-2-thiazolamine 0
                  N-[1-(3-methylbutyl)piperidin-4-yl]-N-\{4-[methyl(pyridin-4-yl)amino]benzyl\}-4-pentylbenzamide 0
                  N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester 4
                  N-[3-[[[3-[(5-bromo-2-pyridinyl)-[(4-chlorophenyl)methyl]amino]propylamino]-sulfanylidenemethyl]amino]propyl]acetamide 0
                  SDZ 35-682 0
                  amifampridine 0
                  aminonicotinic acid + 14
                  ampiroxicam 0
                  azaperone 1
                  butazopyridine 0
                  clonixin 0
                  delavirdine + 1
                  diaminopyridine + 6
                  enasidenib 0
                  ethyl (2R)-4-[(6-chloronaphthalen-2-yl)sulfonyl]-6-oxo-1-[(1-pyridin-4-ylpiperidin-4-yl)methyl]piperazine-2-carboxylate 0
                  fenyramidol 0
                  florpyrauxifen + 0
                  florpyrauxifen-benzyl 0
                  fluazinam 8
                  flunixin 1
                  fluroxypyr 0
                  halauxifen + 0
                  halauxifen-methyl 0
                  hydroxy torasemide 0
                  lorlatinib 3
                  netupitant + 0
                  palbociclib 176
                  pexidartinib 0
                  picloram + 13
                  picloram-methyl 0
                  rosiglitazone + 2
                  sonidegib + 6
                  torasemide + 9
                  torasemide carboxylic acid 0
                  torin 2 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19809
      composite particle 19809
        hadron 19809
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19706
                    main group molecular entity 19706
                      s-block molecular entity 19490
                        hydrogen molecular entity 19485
                          hydrides 18845
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17280
                                    ammonia 17279
                                      organic amino compound 17279
                                        aromatic amine 13702
                                          aminopyridine 366
                                            (8aS)-7-[(6-chloronaphthalen-2-yl)sulfonyl]-8a-(methoxymethyl)-1'-pyridin-4-yltetrahydro-5H-spiro[1,3-oxazolo[3,2-a]pyrazine-2,4'-piperidin]-5-one 0
                                            1-(2-\{[(6-amino-2-methylpyridin-3-yl)methyl]amino\}ethyl)-6-chloro-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-1,4-dihydropyrazin-2-ol 0
                                            1-(3-aminopropyl)-3-[3-[(5-bromo-2-pyridinyl)-[(4-chlorophenyl)methyl]amino]propyl]thiourea 0
                                            1-[3-[(5-bromo-2-pyridinyl)-(phenylmethyl)amino]propyl]-3-[3-(1H-imidazol-5-yl)propyl]thiourea 0
                                            1-[3-[(5-bromo-2-pyridinyl)-[(3,4-dichlorophenyl)methyl]amino]propyl]-3-[3-(1H-imidazol-5-yl)propyl]thiourea 0
                                            1-[3-[(5-bromo-2-pyridinyl)-[(4-chlorophenyl)methyl]amino]propyl]-3-[3-(1H-imidazol-5-yl)propyl]thiourea 0
                                            1-[4-[(5-bromo-2-pyridinyl)-[(4-chlorophenyl)methyl]amino]butyl]-3-[3-(1H-imidazol-5-yl)propyl]thiourea 0
                                            1-acetyl-4-(4-\{4-[(2-ethoxyphenyl)thio]-3-nitrophenyl\}pyridin-2-yl)piperazine 0
                                            1-butyl-3-(2-hydroxyethylamino)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile 0
                                            2-(4-morpholinyl)-N-[1-(phenylmethyl)-2,3-dihydropyrrolo[2,3-b]quinolin-4-yl]acetamide 0
                                            2-(6-methoxy-1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-[4-(piperazin-1-yl)pyridin-3-yl]-1,3-thiazole-4-carboxamide 0
                                            2-[(3-pyridinylamino)methylidene]propanedinitrile 0
                                            2-[[(5-chloro-2-pyridinyl)amino]methylidene]-1-cyclohexanone 0
                                            2-aminonicotinic acid 0
                                            3-(5-chloro-1,3-benzoxazol-2-yl)-N-(phenylmethyl)-2-pyridinamine 0
                                            3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine + 55
                                            3-amino-4-iodopyridine 0
                                            4'-hydroxy torasemide 0
                                            4-Amino-2-chloropyridine 0
                                            4-METHYLPYRIDIN-2-AMINE 0
                                            4-aminonicotinic acid 0
                                            4-aminopyridine + 41
                                            4-aminopyridine-3-methanol 0
                                            4-phenyl-N-(3-pyridinyl)-2-thiazolamine 0
                                            5-[(2-pyridinylamino)methyl]-8-quinolinol 0
                                            5-[4-(dimethylamino)phenyl]-6-[(6-morpholin-4-ylpyridin-3-yl)ethynyl]pyrimidin-4-amine 0
                                            5-aminonicotinic acid 0
                                            5-nitro-N-[(4-propan-2-ylphenyl)methyl]-2-pyridinamine 0
                                            6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7(8H)-one 0
                                            6-aminonicotinamide 14
                                            6-aminonicotinic acid + 14
                                            7-ethyl-1-[(phenylmethyl)amino]-3-(1-piperidinyl)-6,8-dihydro-5H-2,7-naphthyridine-4-carbonitrile 0
                                            BAY 60-6583 5
                                            BKM120 0
                                            CHIR 99021 71
                                            GSK343 2
                                            LSM-24360 0
                                            LSM-24662 0
                                            N'-[(4-chlorophenyl)methyl]-N,N-dimethyl-N'-(2-pyridinyl)ethane-1,2-diamine 0
                                            N,4-bis(3-pyridinyl)-2-thiazolamine 0
                                            N-[1-(3-methylbutyl)piperidin-4-yl]-N-\{4-[methyl(pyridin-4-yl)amino]benzyl\}-4-pentylbenzamide 0
                                            N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester 4
                                            N-[3-[[[3-[(5-bromo-2-pyridinyl)-[(4-chlorophenyl)methyl]amino]propylamino]-sulfanylidenemethyl]amino]propyl]acetamide 0
                                            SDZ 35-682 0
                                            amifampridine 0
                                            aminonicotinic acid + 14
                                            ampiroxicam 0
                                            azaperone 1
                                            butazopyridine 0
                                            clonixin 0
                                            delavirdine + 1
                                            diaminopyridine + 6
                                            enasidenib 0
                                            ethyl (2R)-4-[(6-chloronaphthalen-2-yl)sulfonyl]-6-oxo-1-[(1-pyridin-4-ylpiperidin-4-yl)methyl]piperazine-2-carboxylate 0
                                            fenyramidol 0
                                            florpyrauxifen + 0
                                            florpyrauxifen-benzyl 0
                                            fluazinam 8
                                            flunixin 1
                                            fluroxypyr 0
                                            halauxifen + 0
                                            halauxifen-methyl 0
                                            hydroxy torasemide 0
                                            lorlatinib 3
                                            netupitant + 0
                                            palbociclib 176
                                            pexidartinib 0
                                            picloram + 13
                                            picloram-methyl 0
                                            rosiglitazone + 2
                                            sonidegib + 6
                                            torasemide + 9
                                            torasemide carboxylic acid 0
                                            torin 2 0
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