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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydroxymethylpyridine
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Accession:CHEBI:38196 term browser browse the term
Definition:Any member of the class of pyridines carrying a hydroxymethyl substituent at unspecified position.
Synonyms:related_synonym: hydroxymethylpyridines



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4-pyridoxic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pyridoxic Acid CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avp arginine vasopressin multiple interactions EXP pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of AVP protein] CTD PMID:11102496 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Fn1 fibronectin 1 decreases expression ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid results in decreased expression of FN1 mRNA CTD PMID:18210741 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]] CTD PMID:32941855 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Il6 interleukin 6 multiple interactions ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Silicon Dioxide analog results in increased expression of IL6 protein] CTD PMID:24793913 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]] CTD PMID:24912985 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide multiple interactions EXP pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of OXT protein] CTD PMID:11102496 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
JBrowse link
G P2rx7 purinergic receptor P2X 7 multiple interactions ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate binds to and results in increased activity of P2RX7 protein]
CTD PMID:21638035 PMID:31263019 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [zinc chloride results in increased expression of PARP1 protein] CTD PMID:22253048 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]] CTD PMID:32941855 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
JBrowse link
pyridoxal 5'-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated increases abundance ISO ALPL gene mutant form results in increased abundance of Pyridoxal Phosphate CTD PMID:7550313 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Pyridoxal Phosphate results in decreased expression of BCL2 protein CTD PMID:16690808 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Ddc dopa decarboxylase affects binding
multiple interactions
ISO Chlorpyrifos binds to [DDC protein binds to Pyridoxal Phosphate]; DDC protein binds to Pyridoxal Phosphate; Diazinon binds to [DDC protein binds to Pyridoxal Phosphate]; Glyphosate binds to [DDC protein binds to Pyridoxal Phosphate]; Isoflurophate binds to [DDC protein binds to Pyridoxal Phosphate]; Malathion binds to [DDC protein binds to Pyridoxal Phosphate]; mipafox binds to [DDC protein binds to Pyridoxal Phosphate]; novichok binds to [DDC protein binds to Pyridoxal Phosphate]; O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate binds to [DDC protein binds to Pyridoxal Phosphate]; Paraoxon binds to [DDC protein binds to Pyridoxal Phosphate]; phenyl di-n-pentylphosphinate binds to [DDC protein binds to Pyridoxal Phosphate]; phenylsaligenin cyclic phosphate binds to [DDC protein binds to Pyridoxal Phosphate]; S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate binds to [DDC protein binds to Pyridoxal Phosphate]; Sarin binds to [DDC protein binds to Pyridoxal Phosphate]; Soman binds to [DDC protein binds to Pyridoxal Phosphate]; tabun binds to [DDC protein binds to Pyridoxal Phosphate]; VX binds to [DDC protein binds to Pyridoxal Phosphate]
[DDC protein binds to Pyridoxal Phosphate] which binds to and results in increased metabolism of Levodopa
CTD PMID:35151785 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP Pyridoxal Phosphate inhibits the reaction [Acetaldehyde results in increased expression of FN1 mRNA] CTD PMID:8151099 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fut8 fucosyltransferase 8 multiple interactions
decreases activity
ISO Fucose analog inhibits the reaction [Pyridoxal Phosphate results in decreased activity of FUT8 protein] CTD PMID:12770769 NCBI chr 6:95,949,246...96,176,677
Ensembl chr 6:95,949,991...96,176,677
JBrowse link
G Gad1 glutamate decarboxylase 1 affects binding
multiple interactions
decreases activity
increases activity
ISO
EXP
Chlorpyrifos binds to [GAD1 protein binds to Pyridoxal Phosphate]; Diazinon binds to [GAD1 protein binds to Pyridoxal Phosphate]; GAD1 protein binds to Pyridoxal Phosphate; Glyphosate binds to [GAD1 protein binds to Pyridoxal Phosphate]; Isoflurophate binds to [GAD1 protein binds to Pyridoxal Phosphate]; Malathion binds to [GAD1 protein binds to Pyridoxal Phosphate]; mipafox binds to [GAD1 protein binds to Pyridoxal Phosphate]; novichok binds to [GAD1 protein binds to Pyridoxal Phosphate]; O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate binds to [GAD1 protein binds to Pyridoxal Phosphate]; Paraoxon binds to [GAD1 protein binds to Pyridoxal Phosphate]; phenyl di-n-pentylphosphinate binds to [GAD1 protein binds to Pyridoxal Phosphate]; phenylsaligenin cyclic phosphate binds to [GAD1 protein binds to Pyridoxal Phosphate]; Pyridoxal Phosphate binds to GAD1 protein modified form; S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate binds to [GAD1 protein binds to Pyridoxal Phosphate]; Sarin binds to [GAD1 protein binds to Pyridoxal Phosphate]; Soman binds to [GAD1 protein binds to Pyridoxal Phosphate]; tabun binds to [GAD1 protein binds to Pyridoxal Phosphate]; VX binds to [GAD1 protein binds to Pyridoxal Phosphate]
[GAD1 protein binds to Pyridoxal Phosphate] which binds to and results in increased metabolism of Glutamic Acid
Pyridoxal Phosphate results in decreased activity of GAD1 protein
Pyridoxal Phosphate results in increased activity of GAD1 protein
CTD PMID:171340 PMID:7463050 PMID:15686475 PMID:35151785 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gad2 glutamate decarboxylase 2 affects binding
multiple interactions
ISO Chlorpyrifos binds to [GAD2 protein binds to Pyridoxal Phosphate]; Diazinon binds to [GAD2 protein binds to Pyridoxal Phosphate]; GAD2 protein binds to Pyridoxal Phosphate; Glyphosate binds to [GAD2 protein binds to Pyridoxal Phosphate]; Isoflurophate binds to [GAD2 protein binds to Pyridoxal Phosphate]; Malathion binds to [GAD2 protein binds to Pyridoxal Phosphate]; mipafox binds to [GAD2 protein binds to Pyridoxal Phosphate]; novichok binds to [GAD2 protein binds to Pyridoxal Phosphate]; O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate binds to [GAD2 protein binds to Pyridoxal Phosphate]; Paraoxon binds to [GAD2 protein binds to Pyridoxal Phosphate]; phenyl di-n-pentylphosphinate binds to [GAD2 protein binds to Pyridoxal Phosphate]; phenylsaligenin cyclic phosphate binds to [GAD2 protein binds to Pyridoxal Phosphate]; Pyridoxal Phosphate binds to GAD2 protein; Pyridoxal Phosphate binds to GAD2 protein modified form; S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate binds to [GAD2 protein binds to Pyridoxal Phosphate]; Sarin binds to [GAD2 protein binds to Pyridoxal Phosphate]; Soman binds to [GAD2 protein binds to Pyridoxal Phosphate]; tabun binds to [GAD2 protein binds to Pyridoxal Phosphate]; VX binds to [GAD2 protein binds to Pyridoxal Phosphate]
[GAD2 protein binds to Pyridoxal Phosphate] which binds to and results in increased metabolism of Glutamic Acid
CTD PMID:15686475 PMID:15690345 PMID:15836621 PMID:35151785 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
JBrowse link
G Gh1 growth hormone 1 decreases secretion EXP Pyridoxal Phosphate results in decreased secretion of GH1 protein CTD PMID:16690808 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Hdc histidine decarboxylase multiple interactions
affects binding
ISO [HDC protein binds to Pyridoxal Phosphate] which binds to and results in increased metabolism of Histidine
Chlorpyrifos binds to [HDC protein binds to Pyridoxal Phosphate]; Diazinon binds to [HDC protein binds to Pyridoxal Phosphate]; Glyphosate binds to [HDC protein binds to Pyridoxal Phosphate]; HDC protein binds to Pyridoxal Phosphate; Isoflurophate binds to [HDC protein binds to Pyridoxal Phosphate]; Malathion binds to [HDC protein binds to Pyridoxal Phosphate]; mipafox binds to [HDC protein binds to Pyridoxal Phosphate]; novichok binds to [HDC protein binds to Pyridoxal Phosphate]; O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate binds to [HDC protein binds to Pyridoxal Phosphate]; Paraoxon binds to [HDC protein binds to Pyridoxal Phosphate]; phenyl di-n-pentylphosphinate binds to [HDC protein binds to Pyridoxal Phosphate]; phenylsaligenin cyclic phosphate binds to [HDC protein binds to Pyridoxal Phosphate]; S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate binds to [HDC protein binds to Pyridoxal Phosphate]; Sarin binds to [HDC protein binds to Pyridoxal Phosphate]; Soman binds to [HDC protein binds to Pyridoxal Phosphate]; tabun binds to [HDC protein binds to Pyridoxal Phosphate]; VX binds to [HDC protein binds to Pyridoxal Phosphate]
CTD PMID:35151785 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 multiple interactions ISO Pyridoxal Phosphate binds to and results in increased activity of NRIP1 protein CTD PMID:17277785 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
JBrowse link
G Pdxk pyridoxal kinase decreases activity EXP Pyridoxal Phosphate results in decreased activity of PDXK protein CTD PMID:7463050 NCBI chr20:10,210,276...10,232,314
Ensembl chr20:10,210,289...10,232,110
JBrowse link
G Pomc proopiomelanocortin decreases secretion ISO Pyridoxal Phosphate results in decreased secretion of POMC protein CTD PMID:16690808 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Pyridoxal Phosphate inhibits the reaction [Ethanol results in decreased activity of PPARA protein] CTD PMID:11022051 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Prl prolactin decreases secretion EXP Pyridoxal Phosphate results in decreased secretion of PRL protein CTD PMID:16690808 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Srr serine racemase multiple interactions ISO Pyridoxal Phosphate inhibits the reaction [Hydroxylamine inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]] CTD PMID:27387750 NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011
JBrowse link
pyridoxamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsr glutathione-disulfide reductase decreases activity EXP Pyridoxamine results in decreased activity of GSR protein CTD PMID:24831520 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity ISO Pyridoxamine results in decreased activity of PTGS2 protein CTD PMID:20041722 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Sod2 superoxide dismutase 2 increases activity EXP Pyridoxamine results in increased activity of SOD2 protein CTD PMID:24831520 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sphk1 sphingosine kinase 1 multiple interactions EXP Pyridoxamine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] CTD PMID:21998146 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Pyridoxamine inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA] CTD PMID:15309289 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Pyridoxamine inhibits the reaction [Streptozocin results in increased expression of TNF protein] CTD PMID:15309289 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
pyridoxine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Pyridoxine results in increased expression of BAX mRNA CTD PMID:28716455 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Casp8 caspase 8 increases expression ISO Pyridoxine results in increased expression of CASP8 mRNA CTD PMID:28716455 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Nefl neurofilament light chain increases secretion EXP Pyridoxine results in increased secretion of NEFL protein CTD PMID:34677616 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO
EXP
Pyridoxine results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 multiple interactions ISO Pyridoxine affects the expression of and affects the activity of SHMT1 protein CTD PMID:17482557 NCBI chr10:45,468,698...45,490,833
Ensembl chr10:45,468,700...45,497,820
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    chemical entity 19836
      atom 19836
        nonmetal atom 19764
          nitrogen atom 18947
            nitrogen molecular entity 18947
              organonitrogen compound 18800
                organonitrogen heterocyclic compound 18134
                  pyridines 11513
                    hydroxymethylpyridine 34
                      3-hydroxy-2,4,5-tris(hydroxymethyl)pyridine 0
                      4-deoxypyridoxine 0
                      4-pyridoxic acid + 1
                      5-pyridoxic acid + 0
                      isopyridoxal 0
                      pyridoxal + 23
                      pyridoxamine + 6
                      pyridoxine + 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19722
                        carbon atom 19719
                          organic molecular entity 19719
                            organic molecule 19670
                              organic cyclic compound 19481
                                organic heterocyclic compound 18857
                                  organic heteromonocyclic compound 17808
                                    pyridines 11513
                                      hydroxymethylpyridine 34
                                        3-hydroxy-2,4,5-tris(hydroxymethyl)pyridine 0
                                        4-deoxypyridoxine 0
                                        4-pyridoxic acid + 1
                                        5-pyridoxic acid + 0
                                        isopyridoxal 0
                                        pyridoxal + 23
                                        pyridoxamine + 6
                                        pyridoxine + 5
paths to the root