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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyridone
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Accession:CHEBI:38183 term browser browse the term
Synonyms:related_synonym: pyridones



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3,5,6-trichloropyridine-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
increases expression
ISO 3,5,6-trichloro-2-pyridinol results in decreased activity of ACHE protein
3,5,6-trichloro-2-pyridinol results in increased expression of ACHE mRNA
CTD PMID:21224175 PMID:23220036 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Afp alpha-fetoprotein increases expression
affects expression
ISO 3,5,6-trichloro-2-pyridinol results in increased expression of AFP mRNA
3,5,6-trichloro-2-pyridinol affects the expression of AFP mRNA
CTD PMID:23220036 PMID:25137620 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO 3,5,6-trichloro-2-pyridinol results in decreased activity of BCHE protein CTD PMID:21224175 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA mRNA]; 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA protein] CTD PMID:32017950 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Crh corticotropin releasing hormone multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CRH mRNA CTD PMID:32518293 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CRHR1 mRNA CTD PMID:32518293 NCBI chr10:89,040,203...89,083,481
Ensembl chr10:89,040,203...89,083,481
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CYP11A1 mRNA CTD PMID:32518293 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CYP11B1 mRNA CTD PMID:32518293 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases chemical synthesis ISO CYP2C19 protein results in increased chemical synthesis of 3,5,6-trichloro-2-pyridinol CTD PMID:22281205 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases chemical synthesis ISO CYP3A4 results in increased chemical synthesis of 3,5,6-trichloro-2-pyridinol CTD PMID:20709133 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of ESR2 mRNA CTD PMID:32518293 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 protein] CTD PMID:32017950 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of FKBP5 mRNA CTD PMID:32518293 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIN2B mRNA CTD PMID:32518293 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of HTR1A mRNA CTD PMID:32518293 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of HTR2A mRNA CTD PMID:32518293 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Kdr kinase insert domain receptor increases expression ISO 3,5,6-trichloro-2-pyridinol results in increased expression of KDR mRNA CTD PMID:23220036 PMID:25137620 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Mc2r melanocortin 2 receptor multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of MC2R mRNA CTD PMID:32518293 NCBI chr18:62,001,980...62,015,567
Ensembl chr18:62,004,948...62,015,488
JBrowse link
G Myh6 myosin heavy chain 6 increases expression ISO 3,5,6-trichloro-2-pyridinol results in increased expression of MYH6 mRNA CTD PMID:23220036 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
JBrowse link
G Nanog Nanog homeobox decreases expression ISO 3,5,6-trichloro-2-pyridinol results in decreased expression of NANOG mRNA CTD PMID:23220036 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Nefm neurofilament medium chain decreases expression
increases expression
ISO 3,5,6-trichloro-2-pyridinol results in decreased expression of NEFM mRNA
3,5,6-trichloro-2-pyridinol results in increased expression of NEFM mRNA
CTD PMID:23220036 PMID:25137620 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
JBrowse link
G Nes nestin decreases expression
affects expression
increases expression
ISO 3,5,6-trichloro-2-pyridinol results in decreased expression of NES mRNA
3,5,6-trichloro-2-pyridinol affects the expression of NES mRNA
3,5,6-trichloro-2-pyridinol results in increased expression of NES mRNA
CTD PMID:23220036 PMID:25137620 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of NR3C1 mRNA CTD PMID:32518293 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NR3C2 mRNA CTD PMID:32518293 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of OXT mRNA CTD PMID:32518293 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
JBrowse link
G Oxtr oxytocin receptor multiple interactions ISO [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of OXTR mRNA CTD PMID:32518293 NCBI chr 4:145,598,549...145,614,674
Ensembl chr 4:145,599,561...145,614,674
JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases activity
increases expression
decreases expression
ISO 3,5,6-trichloro-2-pyridinol results in decreased activity of PNPLA6 protein
3,5,6-trichloro-2-pyridinol results in increased expression of PNPLA6 mRNA
3,5,6-trichloro-2-pyridinol results in decreased expression of PNPLA6 mRNA
CTD PMID:23220036 PMID:25137620 NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734
JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression ISO 3,5,6-trichloro-2-pyridinol results in increased expression of POU5F1 mRNA CTD PMID:23220036 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; [3,5,6-trichloro-2-pyridinol co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG protein CTD PMID:32017950 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
CGP 28014 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase decreases activity ISO N-(2-pyridone-6-yl)-N',N'-di-n-propylformamidine results in decreased activity of COMT protein CTD PMID:20726980 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
ciclopirox term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO ciclopirox binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO ciclopirox results in decreased expression of BIRC5 mRNA; ciclopirox results in decreased expression of BIRC5 protein CTD PMID:19589922 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO ciclopirox binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions ISO ciclopirox inhibits the reaction [Dexamethasone results in increased expression of FKBP5 mRNA] CTD PMID:19255438 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 multiple interactions
increases degradation
decreases expression
ISO FLT4 protein inhibits the reaction [ciclopirox results in decreased phosphorylation of MAPK1 protein]; FLT4 protein inhibits the reaction [ciclopirox results in decreased phosphorylation of MAPK3 protein]
ciclopirox results in increased degradation of FLT4 protein
[ciclopirox results in decreased expression of FLT4 protein] which results in decreased phosphorylation of MAPK1 protein; [ciclopirox results in decreased expression of FLT4 protein] which results in decreased phosphorylation of MAPK3 protein
CTD PMID:21217783 NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases stability
EXP
ISO
ciclopirox results in increased expression of and results in increased localization of HIF1A protein
ciclopirox results in increased stability of HIF1A protein
CTD PMID:14600837 PMID:15741220 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 decreases degradation ISO ciclopirox results in decreased degradation of HMOX1 protein CTD PMID:19384570 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO ciclopirox inhibits the reaction [Terfenadine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]]; ciclopirox promotes the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
ISO ciclopirox results in decreased phosphorylation of MAPK1 protein
FLT4 protein inhibits the reaction [ciclopirox results in decreased phosphorylation of MAPK1 protein]
[ciclopirox results in decreased expression of FLT4 protein] which results in decreased phosphorylation of MAPK1 protein; ciclopirox promotes the reaction [U 0126 results in decreased phosphorylation of MAPK1 protein]
CTD PMID:21217783 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO FLT4 protein inhibits the reaction [ciclopirox results in decreased phosphorylation of MAPK3 protein]
[Ciclopirox results in decreased expression of FLT4 protein] which results in decreased phosphorylation of MAPK3 protein; Ciclopirox promotes the reaction [U 0126 results in decreased phosphorylation of MAPK3 protein]
CTD PMID:21217783 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO ciclopirox results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity
decreases expression
ISO ciclopirox results in decreased activity of NR3C1 protein
ciclopirox results in decreased expression of NR3C1 protein
CTD PMID:19255438 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Pgr progesterone receptor multiple interactions ISO ciclopirox binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases activity ISO ciclopirox results in decreased activity of RRM2 protein CTD PMID:19589922 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
JBrowse link
deferiprone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; deferiprone inhibits the reaction [Iron results in increased phosphorylation of AKT1 protein] CTD PMID:17172471 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein] CTD PMID:33285147 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of BCL2 protein] CTD PMID:33285147 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CACNA1C protein] CTD PMID:33285147 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein] CTD PMID:33285147 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
deferiprone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
deferiprone inhibits the reaction [[Lipopolysaccharides co-treated with Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]
CTD PMID:14576080 PMID:25813056 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP
ISO
deferiprone inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; deferiprone inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]]
Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of CHUK protein]
CTD PMID:17172471 PMID:33285147 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions EXP
ISO
Deferiprone inhibits the reaction [erastin results in increased expression of FTH1 protein]
Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 protein]
CTD PMID:32937103 PMID:33285147 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Fxn frataxin increases expression ISO deferiprone results in increased expression of FXN mRNA; deferiprone results in increased expression of FXN protein CTD PMID:23418481 NCBI chr 1:221,874,007...221,897,841
Ensembl chr 1:221,872,420...221,897,540
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP deferiprone inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; deferiprone inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]] CTD PMID:17172471 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
Deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; Deferiprone inhibits the reaction [Iron results in increased phosphorylation of MAPK1 protein]
Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein]
CTD PMID:17172471 PMID:33285147 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO
deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; deferiprone inhibits the reaction [Iron results in increased phosphorylation of MAPK3 protein]
Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein]
CTD PMID:17172471 PMID:33285147 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of NFKBIA protein] CTD PMID:33285147 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein] CTD PMID:33285147 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC11A2 protein] CTD PMID:33285147 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP deferiprone inhibits the reaction [Doxorubicin results in decreased activity of SOD1 protein] CTD PMID:17007740 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Tf transferrin increases expression
decreases uptake
ISO deferiprone results in increased expression of TF mRNA; deferiprone results in increased expression of TF protein
deferiprone results in decreased uptake of TF protein
CTD PMID:9763218 PMID:10865941 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein] CTD PMID:33285147 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO deferiprone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] CTD PMID:14576080 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
GSK343 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dicer1 dicer 1 ribonuclease III increases expression ISO GSK343 results in increased expression of DICER1 mRNA CTD PMID:25351418 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit decreases activity ISO GSK343 results in decreased activity of EZH2 protein CTD PMID:23759589 PMID:24900432 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
JBrowse link
huperzine A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases transport
ISO ABCB1A gene mutant form affects the transport of and results in increased abundance of huperzine A
ABCB1 protein results in increased transport of huperzine A
Elacridar inhibits the reaction [ABCB1 protein results in increased transport of huperzine A]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of huperzine A]
CTD PMID:28587984 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Ache acetylcholinesterase decreases activity
multiple interactions
ISO
EXP
huperzine A results in decreased activity of ACHE protein
huperzine A binds to and results in decreased activity of ACHE protein
ALB protein affects the reaction [huperzine A results in decreased activity of ACHE protein]; huperzine A inhibits the reaction [ACHE protein results in increased hydrolysis of Butyrylthiocholine]
[huperzine A co-treated with tetramethylpyrazine] results in decreased activity of ACHE protein
CTD PMID:15135892 PMID:15652380 PMID:17309523 PMID:18572153 PMID:18573242 More... NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Alb albumin multiple interactions ISO ALB protein affects the reaction [huperzine A results in decreased activity of ACHE protein] CTD PMID:26902639 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing EXP CYP1A2 protein results in increased metabolism of huperzine A CTD PMID:12586202 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing EXP CYP3A2 protein results in increased metabolism of huperzine A CTD PMID:12586202 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases metabolic processing EXP CYP3A23-3A1 protein results in increased metabolism of huperzine A CTD PMID:12586202 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP huperzine A inhibits the reaction [Acetic Acid results in increased expression of IL1B protein] CTD PMID:23810507 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP huperzine A inhibits the reaction [Acetic Acid results in increased expression of RELA protein] CTD PMID:23810507 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP huperzine A inhibits the reaction [Acetic Acid results in increased expression of TNF protein] CTD PMID:23810507 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
L-mimosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arnt aryl hydrocarbon receptor nuclear translocator increases activity EXP Mimosine results in increased activity of ARNT protein CTD PMID:10559391 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Atf1 activating transcription factor 1 increases activity EXP Mimosine results in increased activity of ATF1 protein CTD PMID:10559391 NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO Mimosine affects the expression of BCL2 protein CTD PMID:18058236 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions ISO Mimosine results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:18058236 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Mimosine results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:18058236 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Mimosine results in decreased activity of TNF protein] CTD PMID:15550384 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Mimosine results in decreased expression of CCND1 CTD PMID:10530763 PMID:10995875 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Mimosine results in increased expression of CDKN1A CTD PMID:10530763 PMID:10995875 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Mimosine results in increased expression of CDKN1B CTD PMID:10530763 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases activity EXP Mimosine results in increased activity of CREB1 protein CTD PMID:10559391 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Ece1 endothelin converting enzyme 1 increases expression EXP
ISO
Mimosine results in increased expression of ECE1 mRNA; Mimosine results in increased expression of ECE1 protein CTD PMID:25469848 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
JBrowse link
G Edn1 endothelin 1 increases expression ISO
EXP
Mimosine results in increased expression of EDN1 mRNA; Mimosine results in increased expression of EDN1 protein CTD PMID:25469848 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity
increases expression
EXP
ISO
Mimosine results in increased activity of HIF1A protein
Mimosine results in increased expression of HIF1A protein
CTD PMID:10559391 PMID:24349381 PMID:25469848 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression EXP
ISO
Mimosine results in decreased expression of LHCGR mRNA CTD PMID:19293332 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
JBrowse link
G Nmbr neuromedin B receptor increases expression ISO Mimosine results in increased expression of NMBR protein CTD PMID:24349381 NCBI chr 1:9,115,033...9,146,081
Ensembl chr 1:9,134,889...9,145,462
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO
EXP
Mimosine results in increased expression of SLC2A1 mRNA CTD PMID:25469848 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation EXP Mimosine results in increased phosphorylation of STAT3 protein CTD PMID:25469848 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity
ISO
EXP
Acetylcysteine inhibits the reaction [Mimosine results in decreased activity of TNF protein]; ferrous sulfate inhibits the reaction [Mimosine results in decreased activity of TNF protein]
Acetylcysteine inhibits the reaction [Mimosine results in decreased activity of TNF protein]; CAT protein inhibits the reaction [Mimosine results in decreased activity of TNF protein]
CTD PMID:15550384 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions
increases cleavage
ISO Acetylcysteine inhibits the reaction [Mimosine results in increased cleavage of TNFRSF1A protein] CTD PMID:15550384 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
milrinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1 (class I) increases expression EXP Milrinone results in increased expression of ADH1 mRNA CTD PMID:22936366 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Akip1 A-kinase interacting protein 1 increases expression EXP Milrinone results in increased expression of AKIP1 mRNA CTD PMID:22936366 NCBI chr 1:163,734,730...163,743,648
Ensembl chr 1:163,734,798...163,743,648
JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression EXP Milrinone results in decreased expression of ANGPTL4 mRNA CTD PMID:22936366 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
JBrowse link
G Aqp7 aquaporin 7 decreases expression EXP Milrinone results in decreased expression of AQP7 mRNA CTD PMID:22936366 NCBI chr 5:56,171,649...56,186,642
Ensembl chr 5:56,172,519...56,186,642
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like decreases expression EXP Milrinone results in decreased expression of ARNTL mRNA CTD PMID:22936366 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
JBrowse link
G Aspn asporin increases expression EXP Milrinone results in increased expression of ASPN mRNA CTD PMID:22936366 NCBI chr17:15,079,910...15,104,369
Ensembl chr17:15,080,639...15,104,041
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
ISO Milrinone promotes the reaction [CFTR protein affects the secretion of Chlorides]
Milrinone results in increased activity of CFTR protein
CTD PMID:12714375 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Chtf8 chromosome transmission fidelity factor 8 increases expression EXP Milrinone results in increased expression of CHTF8 mRNA CTD PMID:22936366 NCBI chr19:34,782,005...34,792,306
Ensembl chr19:34,781,856...34,792,578
JBrowse link
G Crem cAMP responsive element modulator increases expression EXP Milrinone results in increased expression of CREM mRNA CTD PMID:22936366 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
JBrowse link
G Crp C-reactive protein decreases expression ISO Milrinone results in decreased expression of CRP protein CTD PMID:11772795 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 increases expression EXP Milrinone results in increased expression of CSRP2 mRNA CTD PMID:22936366 NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745
JBrowse link
G Cthrc1 collagen triple helix repeat containing 1 increases expression EXP Milrinone results in increased expression of CTHRC1 mRNA CTD PMID:22936366 NCBI chr 7:70,122,474...70,132,756
Ensembl chr 7:70,122,474...70,132,756
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression EXP Milrinone results in increased expression of DBP mRNA CTD PMID:22936366 NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
JBrowse link
G Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 decreases expression EXP Milrinone results in decreased expression of EIF4EBP2 mRNA CTD PMID:22936366 NCBI chr20:29,379,444...29,400,131
Ensembl chr20:29,382,668...29,399,946
JBrowse link
G Fam171a1 family with sequence similarity 171, member A1 decreases expression EXP Milrinone results in decreased expression of FAM171A1 mRNA CTD PMID:22936366 NCBI chr17:75,024,582...75,148,348
Ensembl chr17:75,024,575...75,150,255
JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Milrinone results in increased expression of FHL1 mRNA CTD PMID:22936366 NCBI chr  X:134,555,399...134,614,930
Ensembl chr  X:134,555,479...134,614,928
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression EXP Milrinone results in increased expression of GADD45G mRNA CTD PMID:22936366 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP Milrinone results in increased expression of GPNMB mRNA CTD PMID:22936366 NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase increases expression EXP Milrinone results in increased expression of HADH mRNA CTD PMID:22936366 NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353
JBrowse link
G Igkc immunoglobulin kappa constant decreases expression EXP Milrinone results in decreased expression of IGKC mRNA CTD PMID:22936366
G Il6 interleukin 6 multiple interactions ISO Milrinone promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:21088047 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lyz2 lysozyme 2 increases expression EXP Milrinone results in increased expression of LYZ2 mRNA CTD PMID:22936366 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
JBrowse link
G Msi2 musashi RNA-binding protein 2 increases expression EXP Milrinone results in increased expression of MSI2 mRNA CTD PMID:22936366 NCBI chr10:73,143,760...73,510,566
Ensembl chr10:73,147,380...73,510,157
JBrowse link
G Myh7 myosin heavy chain 7 increases expression EXP Milrinone results in increased expression of MYH7 mRNA CTD PMID:22936366 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Myl1 myosin, light chain 1 increases expression EXP Milrinone results in increased expression of MYL1 mRNA CTD PMID:22936366 NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261
JBrowse link
G Noct nocturnin increases expression EXP Milrinone results in increased expression of NOCT mRNA CTD PMID:22936366 NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO Milrinone inhibits the reaction [NOS1 gene mutant form results in decreased secretion of REN1 protein] CTD PMID:20651700 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nppa natriuretic peptide A increases expression EXP Milrinone results in increased expression of NPPA mRNA CTD PMID:22936366 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression EXP Milrinone results in increased expression of NR4A3 mRNA CTD PMID:22936366 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
JBrowse link
G Per2 period circadian regulator 2 increases expression EXP Milrinone results in increased expression of PER2 mRNA CTD PMID:22936366 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
JBrowse link
G Postn periostin increases expression EXP Milrinone results in increased expression of POSTN mRNA CTD PMID:22936366 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
JBrowse link
G Reg3b regenerating family member 3 beta increases expression EXP Milrinone results in increased expression of REG3B mRNA CTD PMID:22936366 NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015
JBrowse link
G Ren renin multiple interactions ISO Milrinone inhibits the reaction [NOS1 gene mutant form results in decreased secretion of REN1 protein] CTD PMID:20651700 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression EXP Milrinone results in increased expression of S100A4 mRNA CTD PMID:22936366 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP Milrinone results in increased expression of SPP1 mRNA CTD PMID:22936366 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Thbs4 thrombospondin 4 increases expression EXP Milrinone results in increased expression of THBS4 mRNA CTD PMID:22936366 NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Milrinone results in increased expression of TIMP1 mRNA CTD PMID:22936366 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Milrinone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:8937731 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
N-methyl-6-pyridone-3-carboxamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of N'-methyl-2-pyridone-5-carboxamide CTD PMID:20567778 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
pirfenidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases expression EXP pirfenidone results in decreased expression of ACE protein CTD PMID:28091615 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin I converting enzyme 2 increases expression EXP pirfenidone results in increased expression of ACE2 protein CTD PMID:28091615 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
ISO
EXP
pirfenidone results in decreased expression of ACTA2 mRNA; pirfenidone results in decreased expression of ACTA2 protein
pirfenidone inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]
CTD PMID:24706986 PMID:28091615 PMID:29273418 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression EXP pirfenidone results in decreased expression of AGTR1 protein CTD PMID:28091615 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO pirfenidone results in decreased expression of BIRC5 mRNA CTD PMID:30481203 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Cat catalase multiple interactions ISO
EXP
pirfenidone inhibits the reaction [Paraquat results in increased activity of CAT protein]
[Prednisolone co-treated with pirfenidone] inhibits the reaction [Paraquat results in decreased activity of CAT protein]; pirfenidone inhibits the reaction [Paraquat results in decreased activity of CAT protein]
CTD PMID:28696894 PMID:28921394 PMID:29273418 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
EXP
ISO
pirfenidone inhibits the reaction [Dimethylnitrosamine results in increased expression of COL1A1 mRNA]
pirfenidone inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]
pirfenidone results in decreased expression of COL1A1 mRNA
CTD PMID:15571005 PMID:27235791 PMID:29273418 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions ISO pirfenidone inhibits the reaction [Paraquat results in increased expression of COL4A1 mRNA] CTD PMID:29273418 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]] which results in decreased phosphorylation of PTPN3 protein; [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]] which results in increased phosphorylation of EGFR protein; lapatinib promotes the reaction [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]]; lapatinib promotes the reaction [pirfenidone inhibits the reaction [EGFR protein binds to PTPN3 protein]]; pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]; pirfenidone inhibits the reaction [EGFR protein binds to PTPN3 protein]; pirfenidone promotes the reaction [lapatinib inhibits the reaction [EGFR protein binds to MAPK12 protein]]; pirfenidone promotes the reaction [lapatinib inhibits the reaction [EGFR protein binds to PTPN3 protein]] CTD PMID:28739874 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [pirfenidone inhibits the reaction [MAPK12 protein results in increased phosphorylation of ESR1 protein]] which results in decreased susceptibility to Tamoxifen; pirfenidone inhibits the reaction [MAPK12 protein results in increased phosphorylation of ESR1 protein] CTD PMID:22399296 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO pirfenidone inhibits the reaction [Paraquat results in decreased expression of GPX1 mRNA] CTD PMID:29273418 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Hdac9 histone deacetylase 9 decreases expression ISO pirfenidone results in decreased expression of HDAC9 mRNA CTD PMID:30481203 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [pirfenidone inhibits the reaction [MAPK12 protein results in increased expression of JUN protein]] which results in decreased susceptibility to Tamoxifen; pirfenidone inhibits the reaction [MAPK12 protein results in increased expression of JUN protein] CTD PMID:22399296 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk12 mitogen-activated protein kinase 12 multiple interactions ISO [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]] which results in decreased phosphorylation of PTPN3 protein; [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]] which results in increased phosphorylation of EGFR protein; [pirfenidone inhibits the reaction [MAPK12 protein results in increased expression of JUN protein]] which results in decreased susceptibility to Tamoxifen; [pirfenidone inhibits the reaction [MAPK12 protein results in increased phosphorylation of ESR1 protein]] which results in decreased susceptibility to Tamoxifen; lapatinib promotes the reaction [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]]; pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]; pirfenidone inhibits the reaction [MAPK12 protein results in increased expression of JUN protein]; pirfenidone inhibits the reaction [MAPK12 protein results in increased phosphorylation of ESR1 protein]; pirfenidone promotes the reaction [lapatinib inhibits the reaction [EGFR protein binds to MAPK12 protein]] CTD PMID:22399296 PMID:28739874 NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664
JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases expression EXP pirfenidone results in decreased expression of MAPK14 protein CTD PMID:28091615 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP pirfenidone inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP2 mRNA]; pirfenidone inhibits the reaction [Paraquat results in increased expression of MMP2 mRNA]; pirfenidone promotes the reaction [Prednisolone inhibits the reaction [Paraquat results in increased expression of MMP2 mRNA]] CTD PMID:15571005 PMID:28696894 PMID:28921394 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO pirfenidone inhibits the reaction [Paraquat results in increased expression of NOS2 mRNA] CTD PMID:29273418 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO pirfenidone inhibits the reaction [Paraquat results in increased expression of NOX1 mRNA] CTD PMID:29273418 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO pirfenidone inhibits the reaction [Paraquat results in increased expression of NOX4 mRNA] CTD PMID:29273418 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression EXP pirfenidone results in increased expression of NR1H3 protein CTD PMID:28091615 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 multiple interactions ISO [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]] which results in decreased phosphorylation of PTPN3 protein; lapatinib promotes the reaction [pirfenidone inhibits the reaction [EGFR protein binds to PTPN3 protein]]; pirfenidone inhibits the reaction [EGFR protein binds to PTPN3 protein]; pirfenidone promotes the reaction [lapatinib inhibits the reaction [EGFR protein binds to PTPN3 protein]] CTD PMID:28739874 NCBI chr 5:71,908,520...72,027,323
Ensembl chr 5:71,911,135...72,065,443
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP pirfenidone inhibits the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 mRNA] CTD PMID:12445421 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Smad7 SMAD family member 7 multiple interactions EXP pirfenidone inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD7 mRNA] CTD PMID:12445421 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP
pirfenidone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]; pirfenidone inhibits the reaction [Paraquat results in increased expression of TGFB1 protein]
pirfenidone inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; pirfenidone inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 mRNA]; pirfenidone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]; pirfenidone promotes the reaction [Prednisolone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]]
CTD PMID:12445421 PMID:15571005 PMID:21619834 PMID:28696894 PMID:28921394 More... NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP pirfenidone inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]; pirfenidone inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA]; pirfenidone inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA]; pirfenidone promotes the reaction [Prednisolone inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA]]; pirfenidone promotes the reaction [Tacrolimus results in decreased expression of TIMP1 mRNA] CTD PMID:12445421 PMID:15571005 PMID:15854665 PMID:28696894 PMID:28921394 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [pirfenidone co-treated with Prednisolone] inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; pirfenidone inhibits the reaction [Paraquat results in increased expression of TNF mRNA] CTD PMID:28696894 PMID:28921394 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          nitrogen atom 18767
            nitrogen molecular entity 18767
              organonitrogen compound 18544
                organonitrogen heterocyclic compound 17661
                  pyridines 9156
                    pyridone 140
                      1-[1-[(2-chloro-6-fluorophenyl)methyl]-2-oxo-3-pyridinyl]-3-(phenylmethyl)urea 0
                      1-[1-[(4-fluorophenyl)methyl]-5-methyl-2-oxo-3-pyridinyl]-3-(phenylmethyl)urea 0
                      2,4-Dihydroxypyridine 0
                      2-(1-hydroxy-1-methoxy-3-methylbutyl)-6-methyl-5H-[1,3]dioxolo[4,5-c]pyridin-4-one 0
                      3,5,6-trichloropyridine-2-one 29
                      3,6-dichloropyridine-2,5-dione 0
                      3,6-dihydroxypyridine-2,5-dione 0
                      3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridone 0
                      4-(3,5-dimethylphenoxy)-5-\{[(furan-2-ylmethyl)sulfanyl]methyl\}-3-iodo-6-methylpyridin-2(1H)-one 0
                      4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid 0
                      4-pyridones + 35
                      5-(2'-carboxyethyl)-4,6-dihydroxypicolinic acid 0
                      5-(3'-carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinic acid 0
                      5-(3'-carboxy-3'-oxopropyl)-4,6-dihydroxypicolinic acid 0
                      6-chloro-3-hydroxypyridine-2,5-dione 0
                      8-epi-ilicicolin H 0
                      CGP 28014 1
                      GSK343 2
                      LLP-3 0
                      N-(2,6-dichlorobenzoyl)-4-[1,6-dimethyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl]-L-phenylalanine 0
                      N-methyl-6-pyridone-3-carboxamide + 1
                      PH 797804 0
                      SPF-32629A 0
                      SPF-32629B 0
                      acromelic acid A 0
                      aspyridone A 0
                      aspyridone B 0
                      chrysogedone A 0
                      chrysogedone B 0
                      ciclopirox + 14
                      emarginatine B 0
                      emarginatine F 0
                      eribaxaban 0
                      huperzine A 9
                      hydroxypyridone antifungal drug + 14
                      ilicicolin H + 0
                      indigoidine 0
                      militarinone A 0
                      milrinone 38
                      perampanel + 0
                      pirfenidone 26
                      piroctone + 0
                      pyridoxatin 0
                      ricinine 0
                      streptokordin 0
                      tert-butyl N-\{1-[(1S)-1-\{[(1R,2S)-1-(benzylcarbamoyl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]carbamoyl\}-2-cyclopropylethyl]-2-oxopyridin-3-yl\}carbamate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organic heteromonocyclic compound 17120
                                    pyridines 9156
                                      pyridone 140
                                        1-[1-[(2-chloro-6-fluorophenyl)methyl]-2-oxo-3-pyridinyl]-3-(phenylmethyl)urea 0
                                        1-[1-[(4-fluorophenyl)methyl]-5-methyl-2-oxo-3-pyridinyl]-3-(phenylmethyl)urea 0
                                        2,4-Dihydroxypyridine 0
                                        2-(1-hydroxy-1-methoxy-3-methylbutyl)-6-methyl-5H-[1,3]dioxolo[4,5-c]pyridin-4-one 0
                                        3,5,6-trichloropyridine-2-one 29
                                        3,6-dichloropyridine-2,5-dione 0
                                        3,6-dihydroxypyridine-2,5-dione 0
                                        3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridone 0
                                        4-(3,5-dimethylphenoxy)-5-\{[(furan-2-ylmethyl)sulfanyl]methyl\}-3-iodo-6-methylpyridin-2(1H)-one 0
                                        4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid 0
                                        4-pyridones + 35
                                        5-(2'-carboxyethyl)-4,6-dihydroxypicolinic acid 0
                                        5-(3'-carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinic acid 0
                                        5-(3'-carboxy-3'-oxopropyl)-4,6-dihydroxypicolinic acid 0
                                        6-chloro-3-hydroxypyridine-2,5-dione 0
                                        8-epi-ilicicolin H 0
                                        CGP 28014 1
                                        GSK343 2
                                        LLP-3 0
                                        N-(2,6-dichlorobenzoyl)-4-[1,6-dimethyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl]-L-phenylalanine 0
                                        N-methyl-6-pyridone-3-carboxamide + 1
                                        PH 797804 0
                                        SPF-32629A 0
                                        SPF-32629B 0
                                        acromelic acid A 0
                                        aspyridone A 0
                                        aspyridone B 0
                                        chrysogedone A 0
                                        chrysogedone B 0
                                        ciclopirox + 14
                                        emarginatine B 0
                                        emarginatine F 0
                                        eribaxaban 0
                                        huperzine A 9
                                        hydroxypyridone antifungal drug + 14
                                        ilicicolin H + 0
                                        indigoidine 0
                                        militarinone A 0
                                        milrinone 38
                                        perampanel + 0
                                        pirfenidone 26
                                        piroctone + 0
                                        pyridoxatin 0
                                        ricinine 0
                                        streptokordin 0
                                        tert-butyl N-\{1-[(1S)-1-\{[(1R,2S)-1-(benzylcarbamoyl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]carbamoyl\}-2-cyclopropylethyl]-2-oxopyridin-3-yl\}carbamate 0
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