Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyridone
go back to main search page
Accession:CHEBI:38183 term browser browse the term
Synonyms:related_synonym: pyridones


show annotations for term's descendants           Sort by:
 
3,5,6-trichloropyridine-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
increases expression
ISO 3,5,6-trichloro-2-pyridinol results in decreased activity of ACHE protein
3,5,6-trichloro-2-pyridinol results in increased expression of ACHE mRNA
CTD PMID:21224175, PMID:23220036 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Afp alpha-fetoprotein increases expression
affects expression
ISO 3,5,6-trichloro-2-pyridinol results in increased expression of AFP mRNA
3,5,6-trichloro-2-pyridinol affects the expression of AFP mRNA
CTD PMID:23220036, PMID:25137620 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO 3,5,6-trichloro-2-pyridinol results in decreased activity of BCHE protein CTD PMID:21224175 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA mRNA]; 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA protein] CTD PMID:32017950 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases chemical synthesis ISO CYP2C19 protein results in increased chemical synthesis of 3,5,6-trichloro-2-pyridinol CTD PMID:22281205 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 protein] CTD PMID:32017950 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Kdr kinase insert domain receptor increases expression ISO 3,5,6-trichloro-2-pyridinol results in increased expression of KDR mRNA CTD PMID:23220036, PMID:25137620 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Myh6 myosin heavy chain 6 increases expression ISO 3,5,6-trichloro-2-pyridinol results in increased expression of MYH6 mRNA CTD PMID:23220036 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
JBrowse link
G Nanog Nanog homeobox decreases expression ISO 3,5,6-trichloro-2-pyridinol results in decreased expression of NANOG mRNA CTD PMID:23220036 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Nefm neurofilament medium decreases expression
increases expression
ISO 3,5,6-trichloro-2-pyridinol results in decreased expression of NEFM mRNA
3,5,6-trichloro-2-pyridinol results in increased expression of NEFM mRNA
CTD PMID:23220036, PMID:25137620 NCBI chr15:44,855,307...44,860,604
Ensembl chr15:44,855,310...44,860,604
JBrowse link
G Nes nestin decreases expression
affects expression
increases expression
ISO 3,5,6-trichloro-2-pyridinol results in decreased expression of NES mRNA
3,5,6-trichloro-2-pyridinol affects the expression of NES mRNA
3,5,6-trichloro-2-pyridinol results in increased expression of NES mRNA
CTD PMID:23220036, PMID:25137620 NCBI chr 2:187,343,109...187,352,972
Ensembl chr 2:187,344,056...187,352,969
JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases activity
increases expression
decreases expression
ISO 3,5,6-trichloro-2-pyridinol results in decreased activity of PNPLA6 protein
3,5,6-trichloro-2-pyridinol results in increased expression of PNPLA6 mRNA
3,5,6-trichloro-2-pyridinol results in decreased expression of PNPLA6 mRNA
CTD PMID:23220036, PMID:25137620 NCBI chr12:2,068,749...2,098,139
Ensembl chr12:2,069,959...2,097,904
JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression ISO 3,5,6-trichloro-2-pyridinol results in increased expression of POU5F1 mRNA CTD PMID:23220036 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO 3,5,6-trichloro-2-pyridinol promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; [3,5,6-trichloro-2-pyridinol co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG protein CTD PMID:32017950 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
CGP 28014 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase decreases activity ISO N-(2-pyridone-6-yl)-N',N'-di-n-propylformamidine results in decreased activity of COMT protein CTD PMID:20726980 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
ciclopirox term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO ciclopirox binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO ciclopirox results in decreased expression of BIRC5 mRNA; ciclopirox results in decreased expression of BIRC5 protein CTD PMID:19589922 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO ciclopirox binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions ISO ciclopirox inhibits the reaction [Dexamethasone results in increased expression of FKBP5 mRNA] CTD PMID:19255438 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020
JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 multiple interactions
increases degradation
decreases expression
ISO FLT4 protein inhibits the reaction [ciclopirox results in decreased phosphorylation of MAPK1 protein]; FLT4 protein inhibits the reaction [ciclopirox results in decreased phosphorylation of MAPK3 protein]
ciclopirox results in increased degradation of FLT4 protein
[ciclopirox results in decreased expression of FLT4 protein] which results in decreased phosphorylation of MAPK1 protein; [ciclopirox results in decreased expression of FLT4 protein] which results in decreased phosphorylation of MAPK3 protein
CTD PMID:21217783 NCBI chr10:35,078,782...35,120,296
Ensembl chr10:35,078,726...35,121,599
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases stability
EXP
ISO
ciclopirox results in increased expression of and results in increased localization of HIF1A protein
ciclopirox results in increased stability of HIF1A protein
CTD PMID:14600837, PMID:15741220 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 decreases degradation ISO ciclopirox results in decreased degradation of HMOX1 protein CTD PMID:19384570 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO ciclopirox inhibits the reaction [Terfenadine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]]; ciclopirox promotes the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
ISO ciclopirox results in decreased phosphorylation of MAPK1 protein
FLT4 protein inhibits the reaction [ciclopirox results in decreased phosphorylation of MAPK1 protein]
[ciclopirox results in decreased expression of FLT4 protein] which results in decreased phosphorylation of MAPK1 protein; ciclopirox promotes the reaction [U 0126 results in decreased phosphorylation of MAPK1 protein]
CTD PMID:21217783 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO FLT4 protein inhibits the reaction [ciclopirox results in decreased phosphorylation of MAPK3 protein]
[Ciclopirox results in decreased expression of FLT4 protein] which results in decreased phosphorylation of MAPK3 protein; Ciclopirox promotes the reaction [U 0126 results in decreased phosphorylation of MAPK3 protein]
CTD PMID:21217783 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO ciclopirox results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity
decreases expression
ISO ciclopirox results in decreased activity of NR3C1 protein
ciclopirox results in decreased expression of NR3C1 protein
CTD PMID:19255438 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Pgr progesterone receptor multiple interactions ISO ciclopirox binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases activity ISO ciclopirox results in decreased activity of RRM2 protein CTD PMID:19589922 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
deferiprone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; deferiprone inhibits the reaction [Iron results in increased phosphorylation of AKT1 protein] CTD PMID:17172471 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
deferiprone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
deferiprone inhibits the reaction [[Lipopolysaccharides co-treated with Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]
CTD PMID:14576080, PMID:25813056 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP deferiprone inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; deferiprone inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]] CTD PMID:17172471 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Fxn frataxin increases expression ISO deferiprone results in increased expression of FXN mRNA; deferiprone results in increased expression of FXN protein CTD PMID:23418481 NCBI chr 1:242,123,975...242,152,834
Ensembl chr 1:242,123,975...242,152,834
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP deferiprone inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; deferiprone inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]] CTD PMID:17172471 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; Deferiprone inhibits the reaction [Iron results in increased phosphorylation of MAPK1 protein] CTD PMID:17172471 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; deferiprone inhibits the reaction [Iron results in increased phosphorylation of MAPK3 protein] CTD PMID:17172471 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP deferiprone inhibits the reaction [Doxorubicin results in decreased activity of SOD1 protein] CTD PMID:17007740 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tf transferrin increases expression
decreases uptake
ISO deferiprone results in increased expression of TF mRNA; deferiprone results in increased expression of TF protein
deferiprone results in decreased uptake of TF protein
CTD PMID:9763218, PMID:10865941 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO deferiprone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] CTD PMID:14576080 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
huperzine A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases transport
ISO ABCB1A gene mutant form affects the transport of and results in increased abundance of huperzine A
ABCB1 protein results in increased transport of huperzine A
Elacridar inhibits the reaction [ABCB1 protein results in increased transport of huperzine A]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of huperzine A]
CTD PMID:28587984 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ache acetylcholinesterase decreases activity
multiple interactions
ISO
EXP
huperzine A results in decreased activity of ACHE protein
huperzine A binds to and results in decreased activity of ACHE protein
ALB protein affects the reaction [huperzine A results in decreased activity of ACHE protein]; huperzine A inhibits the reaction [ACHE protein results in increased hydrolysis of Butyrylthiocholine]
[huperzine A co-treated with tetramethylpyrazine] results in decreased activity of ACHE protein
CTD PMID:15135892, PMID:15652380, PMID:17309523, PMID:18572153, PMID:18573242, PMID:19345205, PMID:20624417, PMID:22407886, PMID:26902639, PMID:27238725 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Alb albumin multiple interactions ISO ALB protein affects the reaction [huperzine A results in decreased activity of ACHE protein] CTD PMID:26902639 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing EXP CYP1A2 protein results in increased metabolism of huperzine A CTD PMID:12586202 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing EXP CYP3A2 protein results in increased metabolism of huperzine A CTD PMID:12586202 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases metabolic processing EXP CYP3A23-3A1 protein results in increased metabolism of huperzine A CTD PMID:12586202 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP huperzine A inhibits the reaction [Acetic Acid results in increased expression of IL1B protein] CTD PMID:23810507 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP huperzine A inhibits the reaction [Acetic Acid results in increased expression of RELA protein] CTD PMID:23810507 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP huperzine A inhibits the reaction [Acetic Acid results in increased expression of TNF protein] CTD PMID:23810507 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
L-mimosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arnt aryl hydrocarbon receptor nuclear translocator increases activity EXP Mimosine results in increased activity of ARNT protein CTD PMID:10559391 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Atf1 activating transcription factor 1 increases activity EXP Mimosine results in increased activity of ATF1 protein CTD PMID:10559391 NCBI chr 7:141,882,261...141,924,790
Ensembl chr 7:141,882,251...141,924,788
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO Mimosine affects the expression of BCL2 protein CTD PMID:18058236 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Mimosine results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:18058236 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Mimosine results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:18058236 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Mimosine results in decreased activity of TNF protein] CTD PMID:15550384 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Mimosine results in decreased expression of CCND1 CTD PMID:10530763, PMID:10995875 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Mimosine results in increased expression of CDKN1A CTD PMID:10530763, PMID:10995875 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Mimosine results in increased expression of CDKN1B CTD PMID:10530763 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases activity EXP Mimosine results in increased activity of CREB1 protein CTD PMID:10559391 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Ece1 endothelin converting enzyme 1 increases expression EXP
ISO
Mimosine results in increased expression of ECE1 mRNA; Mimosine results in increased expression of ECE1 protein CTD PMID:25469848 NCBI chr 5:156,215,469...156,318,652
Ensembl chr 5:156,215,417...156,318,671
JBrowse link
G Edn1 endothelin 1 increases expression ISO
EXP
Mimosine results in increased expression of EDN1 mRNA; Mimosine results in increased expression of EDN1 protein CTD PMID:25469848 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity
increases expression
EXP
ISO
Mimosine results in increased activity of HIF1A protein
Mimosine results in increased expression of HIF1A protein
CTD PMID:10559391, PMID:24349381, PMID:25469848 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression EXP
ISO
Mimosine results in decreased expression of LHCGR mRNA CTD PMID:19293332 NCBI chr 6:12,493,182...12,554,482
Ensembl chr 6:12,493,943...12,554,439
JBrowse link
G Nmbr neuromedin B receptor increases expression ISO Mimosine results in increased expression of NMBR protein CTD PMID:24349381 NCBI chr 1:8,933,744...8,945,850
Ensembl chr 1:8,933,831...8,944,987
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO
EXP
Mimosine results in increased expression of SLC2A1 mRNA CTD PMID:25469848 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation EXP Mimosine results in increased phosphorylation of STAT3 protein CTD PMID:25469848 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity
ISO
EXP
Acetylcysteine inhibits the reaction [Mimosine results in decreased activity of TNF protein]; ferrous sulfate inhibits the reaction [Mimosine results in decreased activity of TNF protein]
Acetylcysteine inhibits the reaction [Mimosine results in decreased activity of TNF protein]; CAT protein inhibits the reaction [Mimosine results in decreased activity of TNF protein]
CTD PMID:15550384 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions
increases cleavage
ISO Acetylcysteine inhibits the reaction [Mimosine results in increased cleavage of TNFRSF1A protein] CTD PMID:15550384 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
milrinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1 (class I) increases expression EXP Milrinone results in increased expression of ADH1 mRNA CTD PMID:22936366 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Akip1 A-kinase interacting protein 1 increases expression EXP Milrinone results in increased expression of AKIP1 mRNA CTD PMID:22936366 NCBI chr 1:174,330,628...174,339,494
Ensembl chr 1:174,330,695...174,339,494
JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression EXP Milrinone results in decreased expression of ANGPTL4 mRNA CTD PMID:22936366 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Aqp7 aquaporin 7 decreases expression EXP Milrinone results in decreased expression of AQP7 mRNA CTD PMID:22936366 NCBI chr 5:57,358,297...57,372,332
Ensembl chr 5:57,358,327...57,372,239
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like decreases expression EXP Milrinone results in decreased expression of ARNTL mRNA CTD PMID:22936366 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
JBrowse link
G Aspn asporin increases expression EXP Milrinone results in increased expression of ASPN mRNA CTD PMID:22936366 NCBI chr17:14,655,958...14,681,355
Ensembl chr17:14,656,009...14,679,409
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
ISO Milrinone promotes the reaction [CFTR protein affects the secretion of Chlorides]
Milrinone results in increased activity of CFTR protein
CTD PMID:12714375 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Chtf8 chromosome transmission fidelity factor 8 increases expression EXP Milrinone results in increased expression of CHTF8 mRNA CTD PMID:22936366 NCBI chr19:39,077,580...39,087,880
Ensembl chr19:39,077,580...39,087,880
JBrowse link
G Crem cAMP responsive element modulator increases expression EXP Milrinone results in increased expression of CREM mRNA CTD PMID:22936366 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Crp C-reactive protein decreases expression ISO Milrinone results in decreased expression of CRP protein CTD PMID:11772795 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 increases expression EXP Milrinone results in increased expression of CSRP2 mRNA CTD PMID:22936366 NCBI chr 7:53,630,675...53,649,309
Ensembl chr 7:53,630,621...53,649,310
JBrowse link
G Cthrc1 collagen triple helix repeat containing 1 increases expression EXP Milrinone results in increased expression of CTHRC1 mRNA CTD PMID:22936366 NCBI chr 7:77,966,722...77,977,004
Ensembl chr 7:77,966,722...77,977,004
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression EXP Milrinone results in increased expression of DBP mRNA CTD PMID:22936366 NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846
JBrowse link
G Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 decreases expression EXP Milrinone results in decreased expression of EIF4EBP2 mRNA CTD PMID:22936366 NCBI chr20:31,055,292...31,072,469
Ensembl chr20:31,055,789...31,072,469
JBrowse link
G Fam171a1 family with sequence similarity 171, member A1 decreases expression EXP Milrinone results in decreased expression of FAM171A1 mRNA CTD PMID:22936366 NCBI chr17:79,030,150...79,149,480
Ensembl chr17:79,031,423...79,085,076
JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Milrinone results in increased expression of FHL1 mRNA CTD PMID:22936366 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression EXP Milrinone results in increased expression of GADD45G mRNA CTD PMID:22936366 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243
JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP Milrinone results in increased expression of GPNMB mRNA CTD PMID:22936366 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase increases expression EXP Milrinone results in increased expression of HADH mRNA CTD PMID:22936366 NCBI chr 2:236,353,445...236,395,067
Ensembl chr 2:236,353,445...236,395,067
JBrowse link
G Igkc immunoglobulin kappa constant decreases expression EXP Milrinone results in decreased expression of IGKC mRNA CTD PMID:22936366
G Il6 interleukin 6 multiple interactions ISO Milrinone promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:21088047 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lyz2 lysozyme 2 increases expression EXP Milrinone results in increased expression of LYZ2 mRNA CTD PMID:22936366 NCBI chr 7:60,335,968...60,341,264
Ensembl chr 7:60,335,969...60,341,264
JBrowse link
G Msi2 musashi RNA-binding protein 2 increases expression EXP Milrinone results in increased expression of MSI2 mRNA CTD PMID:22936366 NCBI chr10:75,673,840...76,040,106
Ensembl chr10:75,681,393...76,039,964
JBrowse link
G Myh7 myosin heavy chain 7 increases expression EXP Milrinone results in increased expression of MYH7 mRNA CTD PMID:22936366 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Myl1 myosin, light chain 1 increases expression EXP Milrinone results in increased expression of MYL1 mRNA CTD PMID:22936366 NCBI chr 9:73,937,820...73,958,480
Ensembl chr 9:73,937,823...73,958,480
JBrowse link
G Noct nocturnin increases expression EXP Milrinone results in increased expression of NOCT mRNA CTD PMID:22936366 NCBI chr 2:140,286,661...140,306,869
Ensembl chr 2:140,286,661...140,306,869
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO Milrinone inhibits the reaction [NOS1 gene mutant form results in decreased secretion of REN1 protein] CTD PMID:20651700 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nppa natriuretic peptide A increases expression EXP Milrinone results in increased expression of NPPA mRNA CTD PMID:22936366 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression EXP Milrinone results in increased expression of NR4A3 mRNA CTD PMID:22936366 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Per2 period circadian regulator 2 increases expression EXP Milrinone results in increased expression of PER2 mRNA CTD PMID:22936366 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
JBrowse link
G Postn periostin increases expression EXP Milrinone results in increased expression of POSTN mRNA CTD PMID:22936366 NCBI chr 2:143,656,820...143,688,087
Ensembl chr 2:143,656,793...143,688,087
JBrowse link
G Reg3b regenerating family member 3 beta increases expression EXP Milrinone results in increased expression of REG3B mRNA CTD PMID:22936366 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G Ren renin multiple interactions ISO Milrinone inhibits the reaction [NOS1 gene mutant form results in decreased secretion of REN1 protein] CTD PMID:20651700 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression EXP Milrinone results in increased expression of S100A4 mRNA CTD PMID:22936366 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP Milrinone results in increased expression of SPP1 mRNA CTD PMID:22936366 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Thbs4 thrombospondin 4 increases expression EXP Milrinone results in increased expression of THBS4 mRNA CTD PMID:22936366 NCBI chr 2:22,343,727...22,385,855
Ensembl chr 2:22,343,727...22,385,855
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Milrinone results in increased expression of TIMP1 mRNA CTD PMID:22936366 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Milrinone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:8937731 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
N-methyl-6-pyridone-3-carboxamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of N'-methyl-2-pyridone-5-carboxamide CTD PMID:20567778 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
pirfenidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases expression EXP pirfenidone results in decreased expression of ACE protein CTD PMID:28091615 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ace2 angiotensin I converting enzyme 2 increases expression EXP pirfenidone results in increased expression of ACE2 protein CTD PMID:28091615 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
ISO
EXP
pirfenidone results in decreased expression of ACTA2 mRNA; pirfenidone results in decreased expression of ACTA2 protein
pirfenidone inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]
CTD PMID:24706986, PMID:28091615, PMID:29273418 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression EXP pirfenidone results in decreased expression of AGTR1 protein CTD PMID:28091615 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO pirfenidone results in decreased expression of BIRC5 mRNA CTD PMID:30481203 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Cat catalase multiple interactions ISO
EXP
pirfenidone inhibits the reaction [Paraquat results in increased activity of CAT protein]
[Prednisolone co-treated with pirfenidone] inhibits the reaction [Paraquat results in decreased activity of CAT protein]; pirfenidone inhibits the reaction [Paraquat results in decreased activity of CAT protein]
CTD PMID:28696894, PMID:28921394, PMID:29273418 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
EXP
ISO
pirfenidone inhibits the reaction [Dimethylnitrosamine results in increased expression of COL1A1 mRNA]
pirfenidone inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]
pirfenidone results in decreased expression of COL1A1 mRNA
CTD PMID:15571005, PMID:27235791, PMID:29273418 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions ISO pirfenidone inhibits the reaction [Paraquat results in increased expression of COL4A1 mRNA] CTD PMID:29273418 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]] which results in decreased phosphorylation of PTPN3 protein; [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]] which results in increased phosphorylation of EGFR protein; lapatinib promotes the reaction [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]]; lapatinib promotes the reaction [pirfenidone inhibits the reaction [EGFR protein binds to PTPN3 protein]]; pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]; pirfenidone inhibits the reaction [EGFR protein binds to PTPN3 protein]; pirfenidone promotes the reaction [lapatinib inhibits the reaction [EGFR protein binds to MAPK12 protein]]; pirfenidone promotes the reaction [lapatinib inhibits the reaction [EGFR protein binds to PTPN3 protein]] CTD PMID:28739874 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [pirfenidone inhibits the reaction [MAPK12 protein results in increased phosphorylation of ESR1 protein]] which results in decreased susceptibility to Tamoxifen; pirfenidone inhibits the reaction [MAPK12 protein results in increased phosphorylation of ESR1 protein] CTD PMID:22399296 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO pirfenidone inhibits the reaction [Paraquat results in decreased expression of GPX1 mRNA] CTD PMID:29273418 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Hdac9 histone deacetylase 9 decreases expression ISO pirfenidone results in decreased expression of HDAC9 mRNA CTD PMID:30481203 NCBI chr 6:53,487,367...54,358,694
Ensembl chr 6:53,488,883...54,059,119
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [pirfenidone inhibits the reaction [MAPK12 protein results in increased expression of JUN protein]] which results in decreased susceptibility to Tamoxifen; pirfenidone inhibits the reaction [MAPK12 protein results in increased expression of JUN protein] CTD PMID:22399296 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mapk12 mitogen-activated protein kinase 12 multiple interactions ISO [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]] which results in decreased phosphorylation of PTPN3 protein; [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]] which results in increased phosphorylation of EGFR protein; [pirfenidone inhibits the reaction [MAPK12 protein results in increased expression of JUN protein]] which results in decreased susceptibility to Tamoxifen; [pirfenidone inhibits the reaction [MAPK12 protein results in increased phosphorylation of ESR1 protein]] which results in decreased susceptibility to Tamoxifen; lapatinib promotes the reaction [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]]; pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]; pirfenidone inhibits the reaction [MAPK12 protein results in increased expression of JUN protein]; pirfenidone inhibits the reaction [MAPK12 protein results in increased phosphorylation of ESR1 protein]; pirfenidone promotes the reaction [lapatinib inhibits the reaction [EGFR protein binds to MAPK12 protein]] CTD PMID:22399296, PMID:28739874 NCBI chr 7:130,109,214...130,120,918
Ensembl chr 7:130,109,663...130,120,579
JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases expression EXP pirfenidone results in decreased expression of MAPK14 protein CTD PMID:28091615 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP pirfenidone inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP2 mRNA]; pirfenidone inhibits the reaction [Paraquat results in increased expression of MMP2 mRNA]; pirfenidone promotes the reaction [Prednisolone inhibits the reaction [Paraquat results in increased expression of MMP2 mRNA]] CTD PMID:15571005, PMID:28696894, PMID:28921394 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO pirfenidone inhibits the reaction [Paraquat results in increased expression of NOS2 mRNA] CTD PMID:29273418 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO pirfenidone inhibits the reaction [Paraquat results in increased expression of NOX1 mRNA] CTD PMID:29273418 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO pirfenidone inhibits the reaction [Paraquat results in increased expression of NOX4 mRNA] CTD PMID:29273418 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression EXP pirfenidone results in increased expression of NR1H3 protein CTD PMID:28091615 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 multiple interactions ISO [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]] which results in decreased phosphorylation of PTPN3 protein; lapatinib promotes the reaction [pirfenidone inhibits the reaction [EGFR protein binds to PTPN3 protein]]; pirfenidone inhibits the reaction [EGFR protein binds to PTPN3 protein]; pirfenidone promotes the reaction [lapatinib inhibits the reaction [EGFR protein binds to PTPN3 protein]] CTD PMID:28739874 NCBI chr 5:74,248,996...74,368,167
Ensembl chr 5:74,248,996...74,368,186
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP pirfenidone inhibits the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 mRNA] CTD PMID:12445421 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Smad7 SMAD family member 7 multiple interactions EXP pirfenidone inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD7 mRNA] CTD PMID:12445421 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP
pirfenidone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]; pirfenidone inhibits the reaction [Paraquat results in increased expression of TGFB1 protein]
pirfenidone inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; pirfenidone inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 mRNA]; pirfenidone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]; pirfenidone promotes the reaction [Prednisolone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]]
CTD PMID:12445421, PMID:15571005, PMID:21619834, PMID:28696894, PMID:28921394, PMID:29273418 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP pirfenidone inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]; pirfenidone inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA]; pirfenidone inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA]; pirfenidone promotes the reaction [Prednisolone inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA]]; pirfenidone promotes the reaction [Tacrolimus results in decreased expression of TIMP1 mRNA] CTD PMID:12445421, PMID:15571005, PMID:15854665, PMID:28696894, PMID:28921394 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [pirfenidone co-treated with Prednisolone] inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; pirfenidone inhibits the reaction [Paraquat results in increased expression of TNF mRNA] CTD PMID:28696894, PMID:28921394 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      atom 19814
        nonmetal atom 19690
          nitrogen atom 18565
            nitrogen molecular entity 18565
              organonitrogen compound 18338
                organonitrogen heterocyclic compound 17485
                  pyridines 8391
                    pyridone 120
                      1-[1-[(2-chloro-6-fluorophenyl)methyl]-2-oxo-3-pyridinyl]-3-(phenylmethyl)urea 0
                      1-[1-[(4-fluorophenyl)methyl]-5-methyl-2-oxo-3-pyridinyl]-3-(phenylmethyl)urea 0
                      3,5,6-trichloropyridine-2-one 14
                      3,6-dichloropyridine-2,5-dione 0
                      3,6-dihydroxypyridine-2,5-dione 0
                      3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridone 0
                      4-(3,5-dimethylphenoxy)-5-\{[(furan-2-ylmethyl)sulfanyl]methyl\}-3-iodo-6-methylpyridin-2(1H)-one 0
                      4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid 0
                      4-pyridones + 28
                      5-(2'-carboxyethyl)-4,6-dihydroxypicolinic acid 0
                      5-(3'-carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinic acid 0
                      5-(3'-carboxy-3'-oxopropyl)-4,6-dihydroxypicolinic acid 0
                      6-chloro-3-hydroxypyridine-2,5-dione 0
                      8-epi-ilicicolin H 0
                      CGP 28014 1
                      LLP-3 0
                      N-(2,6-dichlorobenzoyl)-4-[1,6-dimethyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl]-L-phenylalanine 0
                      N-methyl-6-pyridone-3-carboxamide + 1
                      PH 797804 0
                      SPF-32629A 0
                      SPF-32629B 0
                      acromelic acid A 0
                      aspyridone A 0
                      aspyridone B 0
                      chrysogedone A 0
                      chrysogedone B 0
                      ciclopirox + 14
                      emarginatine B 0
                      emarginatine F 0
                      eribaxaban 0
                      huperzine A 9
                      hydroxypyridone antifungal drug + 14
                      ilicicolin H + 0
                      indigoidine 0
                      militarinone A 0
                      milrinone 38
                      perampanel + 0
                      pirfenidone 26
                      piroctone + 0
                      pyridoxatin 0
                      ricinine 0
                      streptokordin 0
                      tert-butyl N-\{1-[(1S)-1-\{[(1R,2S)-1-(benzylcarbamoyl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]carbamoyl\}-2-cyclopropylethyl]-2-oxopyridin-3-yl\}carbamate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organic heteromonocyclic compound 16469
                                    pyridines 8391
                                      pyridone 120
                                        1-[1-[(2-chloro-6-fluorophenyl)methyl]-2-oxo-3-pyridinyl]-3-(phenylmethyl)urea 0
                                        1-[1-[(4-fluorophenyl)methyl]-5-methyl-2-oxo-3-pyridinyl]-3-(phenylmethyl)urea 0
                                        3,5,6-trichloropyridine-2-one 14
                                        3,6-dichloropyridine-2,5-dione 0
                                        3,6-dihydroxypyridine-2,5-dione 0
                                        3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridone 0
                                        4-(3,5-dimethylphenoxy)-5-\{[(furan-2-ylmethyl)sulfanyl]methyl\}-3-iodo-6-methylpyridin-2(1H)-one 0
                                        4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid 0
                                        4-pyridones + 28
                                        5-(2'-carboxyethyl)-4,6-dihydroxypicolinic acid 0
                                        5-(3'-carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinic acid 0
                                        5-(3'-carboxy-3'-oxopropyl)-4,6-dihydroxypicolinic acid 0
                                        6-chloro-3-hydroxypyridine-2,5-dione 0
                                        8-epi-ilicicolin H 0
                                        CGP 28014 1
                                        LLP-3 0
                                        N-(2,6-dichlorobenzoyl)-4-[1,6-dimethyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl]-L-phenylalanine 0
                                        N-methyl-6-pyridone-3-carboxamide + 1
                                        PH 797804 0
                                        SPF-32629A 0
                                        SPF-32629B 0
                                        acromelic acid A 0
                                        aspyridone A 0
                                        aspyridone B 0
                                        chrysogedone A 0
                                        chrysogedone B 0
                                        ciclopirox + 14
                                        emarginatine B 0
                                        emarginatine F 0
                                        eribaxaban 0
                                        huperzine A 9
                                        hydroxypyridone antifungal drug + 14
                                        ilicicolin H + 0
                                        indigoidine 0
                                        militarinone A 0
                                        milrinone 38
                                        perampanel + 0
                                        pirfenidone 26
                                        piroctone + 0
                                        pyridoxatin 0
                                        ricinine 0
                                        streptokordin 0
                                        tert-butyl N-\{1-[(1S)-1-\{[(1R,2S)-1-(benzylcarbamoyl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]carbamoyl\}-2-cyclopropylethyl]-2-oxopyridin-3-yl\}carbamate 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.