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G |
Mmp1 |
matrix metallopeptidase 1 |
decreases activity |
ISO |
3-hydroxypicolinic acid results in decreased activity of MMP1 protein |
CTD |
PMID:21189019 |
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NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases activity |
ISO |
3-hydroxypicolinic acid results in decreased activity of MMP2 protein |
CTD |
PMID:21189019 |
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NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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G |
Mmp3 |
matrix metallopeptidase 3 |
decreases activity |
ISO |
3-hydroxypicolinic acid results in decreased activity of MMP3 protein |
CTD |
PMID:21189019 |
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NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
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G |
Mmp8 |
matrix metallopeptidase 8 |
decreases activity |
ISO |
3-hydroxypicolinic acid results in decreased activity of MMP8 protein |
CTD |
PMID:21189019 |
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NCBI chr 8:5,768,808...5,777,741
Ensembl chr 8:5,768,811...5,778,702
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G |
Col2a1 |
collagen type II alpha 1 chain |
multiple interactions |
EXP |
[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pyridoxic Acid |
CTD |
PMID:24709313 |
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NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
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G |
Avp |
arginine vasopressin |
multiple interactions |
EXP |
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of AVP protein] |
CTD |
PMID:11102496 |
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NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
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G |
Fn1 |
fibronectin 1 |
decreases expression |
ISO |
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid results in decreased expression of FN1 mRNA |
CTD |
PMID:18210741 |
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NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
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G |
H2ax |
H2A.X variant histone |
multiple interactions |
ISO |
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]] |
CTD |
PMID:32941855 |
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NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Silicon Dioxide analog results in increased expression of IL6 protein] |
CTD |
PMID:24793913 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Nox1 |
NADPH oxidase 1 |
multiple interactions |
ISO |
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]] |
CTD |
PMID:24912985 |
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NCBI chr X:104,909,328...104,932,508
Ensembl chr X:104,909,326...104,932,508
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G |
Oxt |
oxytocin/neurophysin I prepropeptide |
multiple interactions |
EXP |
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of OXT protein] |
CTD |
PMID:11102496 |
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NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
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G |
P2rx7 |
purinergic receptor P2X 7 |
multiple interactions |
ISO |
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein] |
CTD |
PMID:21638035 |
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NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [zinc chloride results in increased expression of PARP1 protein] |
CTD |
PMID:22253048 |
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NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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G |
Tp53bp1 |
tumor protein p53 binding protein 1 |
multiple interactions |
ISO |
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]] |
CTD |
PMID:32941855 |
|
NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790
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G |
Mapt |
microtubule-associated protein tau |
increases response to substance increases phosphorylation |
ISO |
MAPT protein polymorphism results in increased susceptibility to piericidin A piericidin A results in increased phosphorylation of MAPT protein polymorphism |
CTD |
PMID:25437199 |
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NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases activity increases expression |
ISO |
2-hydroxypyridine results in increased activity of CYP1A1 protein 2-hydroxypyridine results in increased expression of CYP1A1 mRNA |
CTD |
PMID:11849738 PMID:12147272 |
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NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G |
Alpl |
alkaline phosphatase, biomineralization associated |
increases abundance |
ISO |
ALPL gene mutant form results in increased abundance of Pyridoxal Phosphate |
CTD |
PMID:7550313 |
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NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
EXP |
Pyridoxal Phosphate results in decreased expression of BCL2 protein |
CTD |
PMID:16690808 |
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NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
EXP |
Pyridoxal Phosphate inhibits the reaction [Acetaldehyde results in increased expression of FN1 mRNA] |
CTD |
PMID:8151099 |
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NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
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G |
Fut8 |
fucosyltransferase 8 |
multiple interactions decreases activity |
ISO |
Fucose analog inhibits the reaction [Pyridoxal Phosphate results in decreased activity of FUT8 protein] |
CTD |
PMID:12770769 |
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NCBI chr 6:100,305,957...100,537,208
Ensembl chr 6:100,337,226...100,537,224
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G |
Gad1 |
glutamate decarboxylase 1 |
affects binding decreases activity increases activity |
ISO EXP |
Pyridoxal Phosphate binds to GAD1 protein modified form Pyridoxal Phosphate results in decreased activity of GAD1 protein Pyridoxal Phosphate results in increased activity of GAD1 protein |
CTD |
PMID:171340 PMID:7463050 PMID:15686475 |
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NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
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G |
Gad2 |
glutamate decarboxylase 2 |
affects binding |
ISO |
Pyridoxal Phosphate binds to GAD2 protein; Pyridoxal Phosphate binds to GAD2 protein modified form |
CTD |
PMID:15686475 PMID:15690345 PMID:15836621 |
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NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040
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G |
Gh1 |
growth hormone 1 |
decreases secretion |
EXP |
Pyridoxal Phosphate results in decreased secretion of GH1 protein |
CTD |
PMID:16690808 |
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NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
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G |
Nrip1 |
nuclear receptor interacting protein 1 |
multiple interactions |
ISO |
Pyridoxal Phosphate binds to and results in increased activity of NRIP1 protein |
CTD |
PMID:17277785 |
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NCBI chr11:14,658,225...14,742,478
Ensembl chr11:14,658,225...14,741,563
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G |
Pomc |
proopiomelanocortin |
decreases secretion |
ISO |
Pyridoxal Phosphate results in decreased secretion of POMC protein |
CTD |
PMID:16690808 |
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NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
EXP |
Pyridoxal Phosphate inhibits the reaction [Ethanol results in decreased activity of PPARA protein] |
CTD |
PMID:11022051 |
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NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
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G |
Prl |
prolactin |
decreases secretion |
EXP |
Pyridoxal Phosphate results in decreased secretion of PRL protein |
CTD |
PMID:16690808 |
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NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
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G |
RGD1566085 |
similar to pyridoxal (pyridoxine, vitamin B6) kinase |
decreases activity |
EXP |
Pyridoxal Phosphate results in decreased activity of PDXK protein |
CTD |
PMID:7463050 |
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NCBI chr20:10,883,952...10,912,870
Ensembl chr20:10,889,573...10,912,769
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G |
Gsr |
glutathione-disulfide reductase |
decreases activity |
EXP |
Pyridoxamine results in decreased activity of GSR protein |
CTD |
PMID:24831520 |
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NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases activity |
ISO |
Pyridoxamine results in decreased activity of PTGS2 protein |
CTD |
PMID:20041722 |
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NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Sod2 |
superoxide dismutase 2 |
increases activity |
EXP |
Pyridoxamine results in increased activity of SOD2 protein |
CTD |
PMID:24831520 |
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NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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G |
Sphk1 |
sphingosine kinase 1 |
multiple interactions |
EXP |
Pyridoxamine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] |
CTD |
PMID:21998146 |
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NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
Pyridoxamine inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA] |
CTD |
PMID:15309289 |
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NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
Pyridoxamine inhibits the reaction [Streptozocin results in increased expression of TNF protein] |
CTD |
PMID:15309289 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
Pyridoxine results in increased expression of BAX mRNA |
CTD |
PMID:28716455 |
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NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Casp8 |
caspase 8 |
increases expression |
ISO |
Pyridoxine results in increased expression of CASP8 mRNA |
CTD |
PMID:28716455 |
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NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
ISO EXP |
Pyridoxine results in increased expression of PPARGC1A mRNA |
CTD |
PMID:23056435 |
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NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
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G |
Shmt1 |
serine hydroxymethyltransferase 1 |
multiple interactions |
ISO |
Pyridoxine affects the expression of and affects the activity of SHMT1 protein |
CTD |
PMID:17482557 |
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NCBI chr10:47,030,813...47,059,216
Ensembl chr10:47,031,050...47,059,216
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
[Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of AKT1 protein; AKT1 protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of GSK3B protein] |
CTD |
PMID:17098228 |
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NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Cd14 |
CD14 molecule |
multiple interactions |
ISO |
[Zinc co-treated with pyrithione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of CD14 protein]]; pyrithione promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of CD14 protein]] |
CTD |
PMID:20089671 |
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NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
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G |
Cd86 |
CD86 molecule |
multiple interactions |
ISO |
pyrithione inhibits the reaction [Lipopolysaccharides results in increased expression of CD86] |
CTD |
PMID:17126599 |
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NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
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G |
Csnk2a1 |
casein kinase 2 alpha 1 |
multiple interactions |
ISO |
2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]]; [Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein] |
CTD |
PMID:22317921 |
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NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862
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G |
Ctnnb1 |
catenin beta 1 |
multiple interactions |
EXP |
[Zinc co-treated with pyrithione] results in increased cleavage of CTNNB1 protein |
CTD |
PMID:17098228 |
|
NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions |
EXP |
[Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of GSK3B protein; AKT1 protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of GSK3B protein]; GSK3B protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein] |
CTD |
PMID:17098228 |
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NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
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G |
Hgf |
hepatocyte growth factor |
multiple interactions |
ISO |
[Zinc co-treated with pyrithione] promotes the reaction [HGF protein results in increased expression of PCNA mRNA] |
CTD |
PMID:22374166 |
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NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
pyrithione analog results in increased expression of HMOX1 mRNA |
CTD |
PMID:23085594 |
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NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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G |
Itgam |
integrin subunit alpha M |
multiple interactions |
ISO |
[Zinc co-treated with pyrithione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of ITGAM protein]]; pyrithione promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of ITGAM protein]] |
CTD |
PMID:20089671 |
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NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:20201035 |
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NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:20201035 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mapt |
microtubule-associated protein tau |
multiple interactions |
EXP |
[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein; GSK3B protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein] |
CTD |
PMID:17098228 |
|
NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
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G |
Mt1 |
metallothionein 1 |
increases expression |
ISO |
pyrithione analog results in increased expression of MT1 mRNA |
CTD |
PMID:23085594 |
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NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
[Zinc co-treated with pyrithione] promotes the reaction [HGF protein results in increased expression of PCNA mRNA] |
CTD |
PMID:22374166 |
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NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
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G |
Ptpn1 |
protein tyrosine phosphatase, non-receptor type 1 |
multiple interactions |
ISO |
[Zinc co-treated with pyrithione] results in decreased activity of PTPN1 protein |
CTD |
PMID:22374166 |
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NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
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G |
Slc39a7 |
solute carrier family 39 member 7 |
multiple interactions |
ISO |
2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]]; [Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein] |
CTD |
PMID:22317921 |
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NCBI chr20:3,819,416...3,822,788
Ensembl chr20:3,819,414...3,822,778
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