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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:triamino-1,3,5-triazine
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Accession:CHEBI:38175 term browser browse the term
Synonyms:related_synonym: triamino-1,3,5-triazines


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cyromazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lep leptin multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lepr leptin receptor multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in decreased expression of LEPR mRNA CTD PMID:29321614 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Nmb neuromedin B multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in decreased expression of NMB mRNA CTD PMID:29321614 NCBI chr 1:142,721,263...142,724,646
Ensembl chr 1:142,721,002...142,724,511
JBrowse link
G Nmbr neuromedin B receptor multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of NMBR mRNA CTD PMID:29321614 NCBI chr 1:8,933,744...8,945,850
Ensembl chr 1:8,933,831...8,944,987
JBrowse link
G Npy1r neuropeptide Y receptor Y1 multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of NPY1R mRNA CTD PMID:29321614 NCBI chr16:24,779,480...24,789,131
Ensembl chr16:24,779,477...24,788,740
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO cyromazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
melamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP melamine results in increased expression of A2M CTD PMID:23052191 NCBI chr 4:154,309,426...154,359,138 JBrowse link
G Alb albumin multiple interactions EXP [melamine co-treated with cyanuric acid] results in increased expression of ALB protein CTD PMID:22610612 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases expression
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of BAD protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of BAD protein]; TGFB1 protein affects the reaction [melamine results in increased expression of BAD protein] CTD PMID:22915474 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of BAX protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of BAX protein]; TGFB1 protein affects the reaction [melamine results in increased expression of BAX protein] CTD PMID:22915474 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO melamine results in decreased expression of BCL2 protein CTD PMID:22915474 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO melamine results in decreased expression of BCL2L1 protein CTD PMID:22915474 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased cleavage of CASP3 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased cleavage of CASP3 protein]; TGFB1 protein affects the reaction [melamine results in increased cleavage of CASP3 protein] CTD PMID:22915474 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased cleavage of CASP9 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased cleavage of CASP9 protein]; TGFB1 protein affects the reaction [melamine results in increased cleavage of CASP9 protein] CTD PMID:22915474 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of CCL2 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [melamine results in increased expression of CCL2 mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [melamine results in increased expression of CCL2 mRNA]; SN50 peptide inhibits the reaction [melamine results in increased expression of CCL2 mRNA] CTD PMID:22915474 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression EXP melamine results in increased expression of CD44 CTD PMID:23052191 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Clu clusterin multiple interactions
increases expression
EXP [cyanuric acid co-treated with melamine] results in increased expression of CLU mRNA; [melamine co-treated with cyanuric acid] results in increased expression of CLU mRNA; [melamine co-treated with cyanuric acid] results in increased expression of CLU protein
melamine results in increased expression of CLU
CTD PMID:21784140 PMID:22610612 PMID:23022069 PMID:23052191 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity ISO melamine results in increased activity of CYP19A1 protein CTD PMID:32113805 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Fn1 fibronectin 1 multiple interactions
increases expression
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of FN1 mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of FN1 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of FN1 mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of FN1 protein]; TGFB1 protein affects the reaction [melamine results in increased expression of FN1 mRNA]; TGFB1 protein affects the reaction [melamine results in increased expression of FN1 protein]
melamine results in increased expression of FN1 mRNA; melamine results in increased expression of FN1 protein
CTD PMID:22915474 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP melamine results in increased expression of GPNMB CTD PMID:23052191 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression EXP melamine results in decreased expression of GRIN1 protein CTD PMID:28206646 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B decreases expression EXP melamine results in decreased expression of GRIN2B protein CTD PMID:28206646 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression
multiple interactions
EXP melamine results in increased expression of HAVCR1
[cyanuric acid co-treated with melamine] results in increased expression of HAVCR1 mRNA; [melamine co-treated with cyanuric acid] results in increased expression of HAVCR1 mRNA; [melamine co-treated with cyanuric acid] results in increased expression of HAVCR1 protein
CTD PMID:21784140 PMID:22610612 PMID:23022069 PMID:23052191 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of IL6 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [melamine results in increased expression of IL6 mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [melamine results in increased expression of IL6 mRNA]; SN50 peptide inhibits the reaction [melamine results in increased expression of IL6 mRNA] CTD PMID:22915474 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lcn2 lipocalin 2 multiple interactions
increases expression
EXP [cyanuric acid co-treated with melamine] results in increased expression of LCN2 mRNA; [melamine co-treated with cyanuric acid] results in increased expression of LCN2 mRNA
melamine results in increased expression of LCN2
CTD PMID:21784140 PMID:23022069 PMID:23052191 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO melamine results in increased phosphorylation of MAPK1 protein CTD PMID:22915474 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO melamine results in increased phosphorylation of MAPK3 protein CTD PMID:22915474 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation ISO melamine results in increased phosphorylation of NFKBIA protein CTD PMID:22915474 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation ISO melamine results in increased phosphorylation of RELA protein CTD PMID:22915474 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP [cyanuric acid co-treated with melamine] results in increased expression of SPP1 mRNA; [melamine co-treated with cyanuric acid] results in increased expression of SPP1 mRNA; [melamine co-treated with cyanuric acid] results in increased expression of SPP1 protein CTD PMID:21784140 PMID:22610612 PMID:23022069 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tff3 trefoil factor 3 decreases expression EXP melamine results in decreased expression of TFF3 CTD PMID:23052191 NCBI chr20:9,850,800...9,855,481
Ensembl chr20:9,850,803...9,855,481
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of TGFB1 mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of TGFB1 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of TGFB1 mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of TGFB1 protein]; SN50 peptide inhibits the reaction [melamine results in increased expression of TGFB1 mRNA]; SN50 peptide inhibits the reaction [melamine results in increased expression of TGFB1 protein]; TGFB1 protein affects the reaction [melamine results in increased cleavage of CASP3 protein]; TGFB1 protein affects the reaction [melamine results in increased cleavage of CASP9 protein]; TGFB1 protein affects the reaction [melamine results in increased expression of BAD protein]; TGFB1 protein affects the reaction [melamine results in increased expression of BAX protein]; TGFB1 protein affects the reaction [melamine results in increased expression of FN1 mRNA]; TGFB1 protein affects the reaction [melamine results in increased expression of FN1 protein]
melamine results in increased expression of TGFB1 mRNA; melamine results in increased expression of TGFB1 protein
CTD PMID:22915474 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [cyanuric acid co-treated with melamine] results in increased expression of TIMP1 mRNA; [melamine co-treated with cyanuric acid] results in increased expression of TIMP1 mRNA CTD PMID:21784140 PMID:23022069 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A increases expression EXP melamine results in increased expression of TNFRSF12A CTD PMID:23052191 NCBI chr10:12,995,904...12,997,930
Ensembl chr10:12,995,904...12,997,930
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
increases expression
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of VCAM1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [melamine results in increased expression of VCAM1 mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of VCAM1 mRNA]; SB 203580 inhibits the reaction [melamine results in increased expression of VCAM1 mRNA]; SN50 peptide inhibits the reaction [melamine results in increased expression of VCAM1 mRNA] CTD PMID:22915474 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    chemical entity 19853
      atom 19851
        nonmetal atom 19733
          nitrogen atom 18620
            nitrogen molecular entity 18620
              organonitrogen compound 18395
                organonitrogen heterocyclic compound 17564
                  triazines 4150
                    1,3,5-triazines 4090
                      triamino-1,3,5-triazine 35
                        5-[(4,6-diamino-1,3,5-triazin-2-yl)amino]-4-hydroxy-3-[(2-sulfophenyl)diazenyl]naphthalene-2,7-disulfonic acid 0
                        ZSTK-474 0
                        almitrine + 0
                        cyromazine 6
                        hexamethylmelamine 0
                        melamine + 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      carbon group element atom 19650
                        carbon atom 19639
                          organic molecular entity 19639
                            organic molecule 19568
                              organic cyclic compound 19378
                                organic heterocyclic compound 18495
                                  heteroarene 16534
                                    azaarene 5359
                                      triazines 4150
                                        1,3,5-triazines 4090
                                          triamino-1,3,5-triazine 35
                                            5-[(4,6-diamino-1,3,5-triazin-2-yl)amino]-4-hydroxy-3-[(2-sulfophenyl)diazenyl]naphthalene-2,7-disulfonic acid 0
                                            ZSTK-474 0
                                            almitrine + 0
                                            cyromazine 6
                                            hexamethylmelamine 0
                                            melamine + 29
paths to the root