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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:physcion
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Accession:CHEBI:38167 term browser browse the term
Definition:A dihydroxyanthraquinone that is 9,10-anthraquinone bearing hydroxy substituents at positions 1 and 8, a methoxy group at position 3, and a methyl group at position 6. It has been widely isolated and characterised from both terrestrial and marine sources.
Synonyms:exact_synonym: 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione
 related_synonym: 1,8-Dihydroxy-3-methoxy-6-methylanthraquinone;   1,8-dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione;   1,8-dihydroxy-3-methyl-6-methoxyanthraquinone;   Emodin monomethyl ether;   Formula=C16H12O5;   InChI=1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3;   InChIKey=FFWOKTFYGVYKIR-UHFFFAOYSA-N;   Parienin;   Physcione;   Rheochrysidin;   SMILES=C12=C(C=C(C=C2C(C=3C=C(C=C(C3C1=O)O)OC)=O)C)O;   parietin
 alt_id: CHEBI:68791
 xref: Beilstein:1915778;   CAS:521-61-9;   KEGG:C17045
 xref_mesh: MESH:C008905
 xref: PMID:16272711;   PMID:17091434;   PMID:17125234;   PMID:17397111;   PMID:17917292;   PMID:17949858;   PMID:17978503;   PMID:17978527;   PMID:18556196;   PMID:18612943;   PMID:19402184;   PMID:19463000;   PMID:19505563;   PMID:20024894;   PMID:20205209;   PMID:20392467;   PMID:20532365;   PMID:21106380;   PMID:21117944;   PMID:21253951;   PMID:21273951;   PMID:21725807;   PMID:21765390;   PMID:21840387;   PMID:22850859;   PMID:23993502;   PMID:24071573;   PMID:25574462;   PMID:25860944;   PMID:26144377;   PMID:26707141;   PMID:26836455;   PMID:27231648;   PMID:27352350;   PMID:27490539;   PMID:27548142;   PMID:27657824;   PMID:27694907;   PMID:27904770;   Reaxys:1915778



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physcion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 increases expression ISO physcione results in increased expression of ABCB11 mRNA; physcione results in increased expression of ABCB11 protein CTD PMID:28161596 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
JBrowse link
G Abcb4 ATP-binding cassette, sub-family B member 4 decreases expression ISO physcione results in decreased expression of ABCB4 mRNA CTD PMID:28161596 NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 decreases expression ISO physcione results in decreased expression of ABCC2 mRNA; physcione results in decreased expression of ABCC2 protein CTD PMID:28161596 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 decreases expression ISO physcione results in decreased expression of ABCC3 mRNA; physcione results in decreased expression of ABCC3 protein CTD PMID:28161596 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
JBrowse link
G Bax BCL2-associated X protein increases expression
decreases expression
ISO physcione results in increased expression of BAX protein
physcione results in decreased expression of BAX protein
CTD PMID:22285236 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO physcione results in decreased activity of CYP1A2 protein CTD PMID:27633141 PMID:33438235 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 increases hydroxylation ISO CYP21A2 protein results in increased hydroxylation of physcione CTD PMID:29667811 NCBI chr17:35,020,322...35,023,400
Ensembl chr17:35,020,322...35,023,535
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO physcione results in decreased expression of CYP27A1 mRNA CTD PMID:28161596 NCBI chr 1:74,752,311...74,777,056
Ensembl chr 1:74,752,733...74,777,051
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases hydroxylation ISO CYP2B6 protein results in increased hydroxylation of physcione CTD PMID:29667811 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 increases hydroxylation ISO CYP2C19 protein results in increased hydroxylation of physcione CTD PMID:29667811 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
JBrowse link
G Cyp8b1 cytochrome P450, family 8, subfamily b, polypeptide 1 decreases expression ISO physcione results in decreased expression of CYP8B1 mRNA; physcione results in decreased expression of CYP8B1 protein CTD PMID:28161596 NCBI chr 9:121,743,422...121,745,371
Ensembl chr 9:121,743,422...121,745,371
JBrowse link
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 decreases expression ISO physcione results in decreased expression of SLC10A1 mRNA; physcione results in decreased expression of SLC10A1 protein CTD PMID:28161596 NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of physcione CTD PMID:24854283 NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22188
    role 22173
      application 21755
        anti-inflammatory agent 17219
          physcion 13
            physcion 8-gentiobioside 0
            torososide B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22188
    subatomic particle 22180
      composite particle 22180
        hadron 22180
          baryon 22180
            nucleon 22180
              atomic nucleus 22180
                atom 22180
                  main group element atom 22114
                    p-block element atom 22114
                      carbon group element atom 21915
                        carbon atom 21840
                          organic molecular entity 21840
                            organic group 20283
                              organic divalent group 20165
                                organodiyl group 20165
                                  carbonyl group 20159
                                    carbonyl compound 20159
                                      ketone 17963
                                        cyclic ketone 16397
                                          quinone 8760
                                            acenoquinone 7821
                                              anthraquinone 517
                                                hydroxyanthraquinones 506
                                                  dihydroxyanthraquinone 354
                                                    physcion 13
                                                      physcion 8-gentiobioside 0
                                                      torososide B 0
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