CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: physcion
Accession: CHEBI:38167
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Definition: A dihydroxyanthraquinone that is 9,10-anthraquinone bearing hydroxy substituents at positions 1 and 8, a methoxy group at position 3, and a methyl group at position 6. It has been widely isolated and characterised from both terrestrial and marine sources.
Synonyms: exact_synonym: 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione
related_synonym: 1,8-Dihydroxy-3-methoxy-6-methylanthraquinone; 1,8-dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione; 1,8-dihydroxy-3-methyl-6-methoxyanthraquinone; Emodin monomethyl ether; Formula=C16H12O5; InChI=1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3; InChIKey=FFWOKTFYGVYKIR-UHFFFAOYSA-N; Parienin; Physcione; Rheochrysidin; SMILES=C12=C(C=C(C=C2C(C=3C=C(C=C(C3C1=O)O)OC)=O)C)O; parietin
alt_id: CHEBI:68791
xref: Beilstein:1915778; CAS:521-61-9; KEGG:C17045
xref_mesh: MESH:C008905
xref: PMID:16272711; PMID:17091434; PMID:17125234; PMID:17397111; PMID:17917292; PMID:17949858; PMID:17978503; PMID:17978527; PMID:18556196; PMID:18612943; PMID:19402184; PMID:19463000; PMID:19505563; PMID:20024894; PMID:20205209; PMID:20392467; PMID:20532365; PMID:21106380; PMID:21117944; PMID:21253951; PMID:21273951; PMID:21725807; PMID:21765390; PMID:21840387; PMID:22850859; PMID:23993502; PMID:24071573; PMID:25574462; PMID:25860944; PMID:26144377; PMID:26707141; PMID:26836455; PMID:27231648; PMID:27352350; PMID:27490539; PMID:27548142; PMID:27657824; PMID:27694907; PMID:27904770; Reaxys:1915778
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Abcb11
ATP-binding cassette, sub-family B member 11
increases expression
ISO
physcione results in increased expression of ABCB11 mRNA; physcione results in increased expression of ABCB11 protein
CTD
PMID:28161596
NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
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Abcb4
ATP-binding cassette, sub-family B member 4
decreases expression
ISO
physcione results in decreased expression of ABCB4 mRNA
CTD
PMID:28161596
NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
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Abcc2
ATP-binding cassette, sub-family member 2
decreases expression
ISO
physcione results in decreased expression of ABCC2 mRNA; physcione results in decreased expression of ABCC2 protein
CTD
PMID:28161596
NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
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Abcc3
ATP-binding cassette, sub-family C member 3
decreases expression
ISO
physcione results in decreased expression of ABCC3 mRNA; physcione results in decreased expression of ABCC3 protein
CTD
PMID:28161596
NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
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Bax
BCL2-associated X protein
increases expression decreases expression
ISO
physcione results in increased expression of BAX protein physcione results in decreased expression of BAX protein
CTD
PMID:22285236
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases activity
ISO
physcione results in decreased activity of CYP1A2 protein
CTD
PMID:27633141 PMID:33438235
NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
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Cyp21a1
cytochrome P450, family 21, subfamily a, polypeptide 1
increases hydroxylation
ISO
CYP21A2 protein results in increased hydroxylation of physcione
CTD
PMID:29667811
NCBI chr17:35,020,322...35,023,400
Ensembl chr17:35,020,322...35,023,535
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Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
decreases expression
ISO
physcione results in decreased expression of CYP27A1 mRNA
CTD
PMID:28161596
NCBI chr 1:74,752,311...74,777,056
Ensembl chr 1:74,752,733...74,777,051
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Cyp2b10
cytochrome P450, family 2, subfamily b, polypeptide 10
increases hydroxylation
ISO
CYP2B6 protein results in increased hydroxylation of physcione
CTD
PMID:29667811
NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
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Cyp2c38
cytochrome P450, family 2, subfamily c, polypeptide 38
increases hydroxylation
ISO
CYP2C19 protein results in increased hydroxylation of physcione
CTD
PMID:29667811
NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
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Cyp8b1
cytochrome P450, family 8, subfamily b, polypeptide 1
decreases expression
ISO
physcione results in decreased expression of CYP8B1 mRNA; physcione results in decreased expression of CYP8B1 protein
CTD
PMID:28161596
NCBI chr 9:121,743,422...121,745,371
Ensembl chr 9:121,743,422...121,745,371
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Slc10a1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
decreases expression
ISO
physcione results in decreased expression of SLC10A1 mRNA; physcione results in decreased expression of SLC10A1 protein
CTD
PMID:28161596
NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479
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Ugt1a9
UDP glucuronosyltransferase 1 family, polypeptide A9
increases glucuronidation
ISO
UGT1A9 protein results in increased glucuronidation of physcione
CTD
PMID:24854283
NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719
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