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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:physcion
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Accession:CHEBI:38167 term browser browse the term
Definition:A dihydroxyanthraquinone that is 9,10-anthraquinone bearing hydroxy substituents at positions 1 and 8, a methoxy group at position 3, and a methyl group at position 6. It has been widely isolated and characterised from both terrestrial and marine sources.
Synonyms:exact_synonym: 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione
 related_synonym: 1,8-Dihydroxy-3-methoxy-6-methylanthraquinone;   1,8-dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione;   1,8-dihydroxy-3-methyl-6-methoxyanthraquinone;   Emodin monomethyl ether;   Formula=C16H12O5;   InChI=1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3;   InChIKey=FFWOKTFYGVYKIR-UHFFFAOYSA-N;   Parienin;   Physcione;   Rheochrysidin;   SMILES=C12=C(C=C(C=C2C(C=3C=C(C=C(C3C1=O)O)OC)=O)C)O;   parietin
 alt_id: CHEBI:68791
 xref: Beilstein:1915778;   CAS:521-61-9;   KEGG:C17045
 xref_mesh: MESH:C008905
 xref: PMID:16272711;   PMID:17091434;   PMID:17125234;   PMID:17397111;   PMID:17917292;   PMID:17949858;   PMID:17978503;   PMID:17978527;   PMID:18556196;   PMID:18612943;   PMID:19402184;   PMID:19463000;   PMID:19505563;   PMID:20024894;   PMID:20205209;   PMID:20392467;   PMID:20532365;   PMID:21106380;   PMID:21117944;   PMID:21253951;   PMID:21273951;   PMID:21725807;   PMID:21765390;   PMID:21840387;   PMID:22850859;   PMID:23993502;   PMID:24071573;   PMID:25574462;   PMID:25860944;   PMID:26144377;   PMID:26707141;   PMID:26836455;   PMID:27231648;   PMID:27352350;   PMID:27490539;   PMID:27548142;   PMID:27657824;   PMID:27694907;   PMID:27904770;   Reaxys:1915778


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physcion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 increases expression EXP physcione results in increased expression of ABCB11 mRNA; physcione results in increased expression of ABCB11 protein CTD PMID:28161596 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression EXP physcione results in decreased expression of ABCB4 mRNA CTD PMID:28161596 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression EXP physcione results in decreased expression of ABCC2 mRNA; physcione results in decreased expression of ABCC2 protein CTD PMID:28161596 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases expression EXP physcione results in decreased expression of ABCC3 mRNA; physcione results in decreased expression of ABCC3 protein CTD PMID:28161596 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
decreases expression
ISO physcione results in increased expression of BAX protein
physcione results in decreased expression of BAX protein
CTD PMID:22285236 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO physcione results in decreased activity of CYP1A2 protein CTD PMID:27633141 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression EXP physcione results in decreased expression of CYP27A1 mRNA CTD PMID:28161596 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases hydroxylation ISO CYP2B6 protein results in increased hydroxylation of physcione CTD PMID:29667811 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases hydroxylation ISO CYP2C19 protein results in increased hydroxylation of physcione CTD PMID:29667811 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases hydroxylation ISO CYP3A4 protein results in increased hydroxylation of physcione CTD PMID:29667811 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP physcione results in decreased expression of CYP8B1 mRNA; physcione results in decreased expression of CYP8B1 protein CTD PMID:28161596 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP physcione results in decreased expression of SLC10A1 mRNA; physcione results in decreased expression of SLC10A1 protein CTD PMID:28161596 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases activity ISO physcione results in decreased activity of SULT1A1 protein CTD PMID:27633141 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of physcione CTD PMID:24854283 NCBI chr 9:88,696,981...88,808,465 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        anti-inflammatory agent 15831
          physcion 14
            physcion 8-gentiobioside 0
            torososide B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      ketone 16923
                                        cyclic ketone 15391
                                          quinone 8379
                                            acenoquinone 7512
                                              anthraquinone 475
                                                hydroxyanthraquinones 465
                                                  dihydroxyanthraquinone 321
                                                    physcion 14
                                                      physcion 8-gentiobioside 0
                                                      torososide B 0
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