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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:physcion
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Accession:CHEBI:38167 term browser browse the term
Definition:A dihydroxyanthraquinone that is 9,10-anthraquinone bearing hydroxy substituents at positions 1 and 8, a methoxy group at position 3, and a methyl group at position 6. It has been widely isolated and characterised from both terrestrial and marine sources.
Synonyms:exact_synonym: 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione
 related_synonym: 1,8-Dihydroxy-3-methoxy-6-methylanthraquinone;   1,8-dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione;   1,8-dihydroxy-3-methyl-6-methoxyanthraquinone;   Emodin monomethyl ether;   Formula=C16H12O5;   InChI=1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3;   InChIKey=FFWOKTFYGVYKIR-UHFFFAOYSA-N;   Parienin;   Physcione;   Rheochrysidin;   SMILES=C12=C(C=C(C=C2C(C=3C=C(C=C(C3C1=O)O)OC)=O)C)O;   parietin
 alt_id: CHEBI:68791
 xref: Beilstein:1915778;   CAS:521-61-9;   KEGG:C17045
 xref_mesh: MESH:C008905
 xref: PMID:16272711;   PMID:17091434;   PMID:17125234;   PMID:17397111;   PMID:17917292;   PMID:17949858;   PMID:17978503;   PMID:17978527;   PMID:18556196;   PMID:18612943;   PMID:19402184;   PMID:19463000;   PMID:19505563;   PMID:20024894;   PMID:20205209;   PMID:20392467;   PMID:20532365;   PMID:21106380;   PMID:21117944;   PMID:21253951;   PMID:21273951;   PMID:21725807;   PMID:21765390;   PMID:21840387;   PMID:22850859;   PMID:23993502;   PMID:24071573;   PMID:25574462;   PMID:25860944;   PMID:26144377;   PMID:26707141;   PMID:26836455;   PMID:27231648;   PMID:27352350;   PMID:27490539;   PMID:27548142;   PMID:27657824;   PMID:27694907;   PMID:27904770;   Reaxys:1915778


show annotations for term's descendants           Sort by:
physcion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 increases expression EXP physcione results in increased expression of ABCB11 mRNA; physcione results in increased expression of ABCB11 protein CTD PMID:28161596 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression EXP physcione results in decreased expression of ABCB4 mRNA CTD PMID:28161596 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression EXP physcione results in decreased expression of ABCC2 mRNA; physcione results in decreased expression of ABCC2 protein CTD PMID:28161596 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases expression EXP physcione results in decreased expression of ABCC3 mRNA; physcione results in decreased expression of ABCC3 protein CTD PMID:28161596 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
decreases expression		 ISO physcione results in increased expression of BAX protein
physcione results in decreased expression of BAX protein		 CTD PMID:22285236 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO physcione results in decreased activity of CYP1A2 protein CTD PMID:27633141 PMID:33438235 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression EXP physcione results in decreased expression of CYP27A1 mRNA CTD PMID:28161596 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases hydroxylation ISO CYP2B6 protein results in increased hydroxylation of physcione CTD PMID:29667811 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases hydroxylation ISO CYP2C19 protein results in increased hydroxylation of physcione CTD PMID:29667811 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases hydroxylation ISO CYP3A4 protein results in increased hydroxylation of physcione CTD PMID:29667811 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP physcione results in decreased expression of CYP8B1 mRNA; physcione results in decreased expression of CYP8B1 protein CTD PMID:28161596 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP physcione results in decreased expression of SLC10A1 mRNA; physcione results in decreased expression of SLC10A1 protein CTD PMID:28161596 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases activity ISO physcione results in decreased activity of SULT1A1 protein CTD PMID:27633141 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of physcione CTD PMID:24854283 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19896
      application 19732
        anti-inflammatory agent 16521
          physcion 14
            physcion 8-gentiobioside 0
            torososide B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19867
                    p-block element atom 19867
                      carbon group element atom 19812
                        carbon atom 19807
                          organic molecular entity 19807
                            organic group 18971
                              organic divalent group 18952
                                organodiyl group 18952
                                  carbonyl group 18905
                                    carbonyl compound 18905
                                      ketone 17193
                                        cyclic ketone 15708
                                          quinone 8574
                                            acenoquinone 7642
                                              anthraquinone 514
                                                hydroxyanthraquinones 503
                                                  dihydroxyanthraquinone 343
                                                    physcion 14
                                                      physcion 8-gentiobioside 0
                                                      torososide B 0
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