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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:organic heterooctacyclic compound
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Accession:CHEBI:38165 term browser browse the term
Synonyms:related_synonym: organic heterooctacyclic compounds


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KT 5720 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO KT 5720 inhibits the reaction [Capsaicin results in increased expression of ABCA1 protein] CTD PMID:21908651 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO KT 5720 results in decreased activity of ABCB1 protein CTD PMID:15725475 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO
EXP
KT 5720 inhibits the reaction [Bucladesine affects the localization of ABCC2 protein]; KT 5720 inhibits the reaction [Bucladesine results in increased expression of ABCC2 mRNA]; KT 5720 inhibits the reaction [Bucladesine results in increased expression of ABCC2 protein]
KT 5720 inhibits the reaction [Bucladesine affects the localization of ABCC2 protein]; KT 5720 inhibits the reaction [Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein]
CTD PMID:26049102 PMID:29052767 PMID:31300867 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions ISO KT 5720 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium] CTD PMID:15365637 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP KT 5720 inhibits the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein] CTD PMID:31300867 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO KT 5720 inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]] CTD PMID:24254769 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO KT 5720 inhibits the reaction [Bucladesine results in increased expression of ATF2 protein modified form] CTD PMID:26049102 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP KT 5720 inhibits the reaction [NPPA protein results in increased secretion of CALCA protein] CTD PMID:17522345 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Cartpt CART prepropeptide multiple interactions EXP KT 5720 inhibits the reaction [CARTPT protein results in increased phosphorylation of GRIN1 protein] CTD PMID:19632277 NCBI chr 2:30,125,249...30,127,408
Ensembl chr 2:30,125,249...30,127,269
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
KT 5720 inhibits the reaction [cilostazol results in increased activity of CASP3 protein]; KT 5720 inhibits the reaction [Colforsin results in increased activity of CASP3 protein]
KT 5720 inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased cleavage of CASP3 protein]
KT 5720 inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]
CTD PMID:20131233 PMID:21873648 PMID:32115946 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO KT 5720 affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]; KT 5720 promotes the reaction [Acetylcholine binds to CHRM1 protein]; KT 5720 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]; Staurosporine affects the reaction [KT 5720 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]] CTD PMID:10860942 PMID:16439611 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO KT 5720 promotes the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:10860942 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 affects binding EXP KT 5720 binds to CHRM3 protein CTD PMID:12435818 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Cidec cell death-inducing DFFA-like effector c multiple interactions ISO KT 5720 inhibits the reaction [Isoproterenol results in increased expression of CIDEC protein] CTD PMID:21097823 NCBI chr 4:145,377,482...145,390,497
Ensembl chr 4:145,377,431...145,390,497
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 multiple interactions ISO KT 5720 inhibits the reaction [cilostazol results in increased phosphorylation of CSNK2A1 protein] CTD PMID:24254769 NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO KT 5720 inhibits the reaction [cilostazol affects the expression of EP300 protein] CTD PMID:24254769 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions EXP KT 5720 inhibits the reaction [Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]] CTD PMID:15264218 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions EXP KT 5720 inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein] CTD PMID:22645130 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP KT 5720 inhibits the reaction [CARTPT protein results in increased phosphorylation of GRIN1 protein] CTD PMID:19632277 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO KT 5720 inhibits the reaction [Bucladesine results in increased expression of GSTA1 mRNA] CTD PMID:26049102 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions ISO KT 5720 inhibits the reaction [Bucladesine results in increased expression of GSTA2 mRNA] CTD PMID:26049102 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta4 glutathione S-transferase alpha 4 multiple interactions ISO KT 5720 inhibits the reaction [Bucladesine results in increased expression of GSTA4 mRNA] CTD PMID:26049102 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP
ISO
KT 5720 inhibits the reaction [Nitroprusside results in increased expression of HMOX1 protein]
Dinoprostone inhibits the reaction [KT 5720 promotes the reaction [Lipopolysaccharides results in increased activity of HMOX1 protein]]; KT 5720 inhibits the reaction [Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; KT 5720 promotes the reaction [Lipopolysaccharides results in increased activity of HMOX1 protein]; KT 5720 promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]
CTD PMID:16439612 PMID:24003391 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO KT 5720 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]] CTD PMID:8904084 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO KT 5720 inhibits the reaction [2-(2-fluorobenzamido)benzoate ethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]] CTD PMID:21457779 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO KT 5720 inhibits the reaction [Bucladesine results in increased expression of JUN protein modified form]; KT 5720 inhibits the reaction [Bucladesine results in increased expression of JUN protein] CTD PMID:26049102 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Lrp1 LDL receptor related protein 1 multiple interactions ISO KT 5720 inhibits the reaction [Capsaicin results in decreased expression of LRP1 protein] CTD PMID:21908651 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO KT 5720 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK1 protein]] CTD PMID:11675405 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO KT 5720 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK3 protein]] CTD PMID:11675405 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP KT 5720 inhibits the reaction [Mevinphos results in increased expression of NOS1 protein] CTD PMID:17438462 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP KT 5720 inhibits the reaction [NPPA protein results in increased secretion of CALCA protein] CTD PMID:17522345 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nucb2 nucleobindin 2 multiple interactions EXP KT 5720 inhibits the reaction [NUCB2 protein results in increased import of Calcium] CTD PMID:17627999 NCBI chr 1:185,106,773...185,143,278
Ensembl chr 1:185,104,656...185,143,272
JBrowse link
G Pla2g6 phospholipase A2 group VI multiple interactions EXP KT 5720 inhibits the reaction [UCN protein results in decreased expression of PLA2G6 protein] CTD PMID:17885217 NCBI chr 7:120,519,479...120,559,716
Ensembl chr 7:120,519,467...120,559,347
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP KT 5720 inhibits the reaction [Bucladesine results in increased activity of PRKACA protein]; KT 5720 inhibits the reaction [Taurolithocholic Acid results in increased activity of PRKACA protein] CTD PMID:31300867 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [KT 5720 co-treated with Dinoprostone] inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; KT 5720 affects the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:24003391 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO KT 5720 inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; KT 5720 inhibits the reaction [cilostazol results in increased phosphorylation of SIRT1 protein] CTD PMID:24254769 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions EXP KT 5720 inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein] CTD PMID:22645130 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO KT 5720 inhibits the reaction [isoeugenol results in increased expression of SOCS3 mRNA] CTD PMID:21969073 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Th tyrosine hydroxylase decreases expression
multiple interactions
EXP KT 5720 results in decreased expression of TH mRNA
KT 5720 inhibits the reaction [Colforsin results in increased expression of TH mRNA]; KT 5720 inhibits the reaction [HU 211 results in decreased expression of TH mRNA]
CTD PMID:18992715 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO KT 5720 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of TNF mRNA]]; KT 5720 inhibits the reaction [Terbutaline results in decreased expression of TNF mRNA] CTD PMID:11675405 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions EXP KT 5720 inhibits the reaction [modafinil results in increased expression of TNFSF11 mRNA] CTD PMID:29649498 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Ucn urocortin multiple interactions EXP KT 5720 inhibits the reaction [UCN protein results in decreased expression of PLA2G6 protein] CTD PMID:17885217 NCBI chr 6:26,602,144...26,602,974
Ensembl chr 6:26,602,144...26,602,974
JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions ISO KT 5720 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein] CTD PMID:21969073 NCBI chr 1:85,380,088...85,382,565
Ensembl chr 1:85,380,088...85,382,569
JBrowse link
KT 5823 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO KT 5823 inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; KT 5823 inhibits the reaction [Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arhgef17 Rho guanine nucleotide exchange factor 17 multiple interactions ISO KT 5823 inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP promotes the reaction [PRKG1 protein binds to and results in increased phosphorylation of ARHGEF17 protein]] CTD PMID:23195829 Ensembl chr 1:165,911,718...165,967,069 JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP
ISO
KT 5823 inhibits the reaction [BDNF protein results in decreased susceptibility to 3-nitropropionic acid]
KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in decreased expression of BDNF protein]]
CTD PMID:19428112 PMID:22850435 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Casp3 caspase 3 multiple interactions ISO KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [TNF protein results in increased activity of CASP3 protein]] CTD PMID:9388267 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO KT 5823 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein] CTD PMID:10860942 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO KT 5823 promotes the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:10860942 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO KT 5823 inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; KT 5823 inhibits the reaction [Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crebbp CREB binding protein multiple interactions ISO KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in decreased expression of CREBBP protein]] CTD PMID:22850435 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP KT 5823 inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]; KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]; KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:12184995 PMID:16389725 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Edn3 endothelin 3 multiple interactions EXP KT 5823 inhibits the reaction [EDN3 protein results in decreased secretion of Norepinephrine] CTD PMID:12184995 NCBI chr 3:172,856,730...172,879,276
Ensembl chr 3:172,856,733...172,880,450
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO KT 5823 inhibits the reaction [bisphenol A promotes the reaction [FOS protein binds to GPER1 promoter]] CTD PMID:23274518 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions EXP KT 5823 inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein] CTD PMID:17110411 PMID:17290048 NCBI chr15:44,441,856...44,446,064
Ensembl chr15:44,442,555...44,442,875
Ensembl chr15:44,442,555...44,442,875
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions ISO KT 5823 inhibits the reaction [bisphenol A promotes the reaction [FOS protein binds to GPER1 promoter]]; KT 5823 inhibits the reaction [bisphenol A results in increased expression of GPER1 mRNA]; KT 5823 inhibits the reaction [bisphenol A results in increased expression of GPER1 protein] CTD PMID:23274518 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity ISO KT 5823 results in decreased activity of GSK3B protein CTD PMID:12534346 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO KT 5823 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]] CTD PMID:8904084 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]
KT 5823 affects the reaction [heat stable toxin (E coli) results in decreased phosphorylation of MAPK1 protein]
KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK1 protein]]
CTD PMID:16389725 PMID:17828804 PMID:22850435 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO
KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]
KT 5823 affects the reaction [heat stable toxin (E coli) results in decreased phosphorylation of MAPK3 protein]
KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK3 protein]]
CTD PMID:16389725 PMID:17828804 PMID:22850435 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 decreases activity ISO KT 5823 results in decreased activity of MAPKAPK5 protein CTD PMID:12534346 NCBI chr12:40,510,378...40,529,332
Ensembl chr12:40,510,378...40,529,338
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO KT 5823 affects the reaction [heat stable toxin (E coli) results in decreased phosphorylation of MYC protein] CTD PMID:17828804 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO KT 5823 inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 mRNA]; KT 5823 inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein] CTD PMID:27774770 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO KT 5823 inhibits the reaction [Dipyridamole results in increased secretion of PLAT protein] CTD PMID:15733978 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions ISO KT 5823 inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP promotes the reaction [PRKG1 protein binds to and results in increased phosphorylation of ARHGEF17 protein]]; KT 5823 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of RHOA protein] CTD PMID:23195829 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO KT 5823 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of RHOA protein] CTD PMID:23195829 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP KT 5823 inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; KT 5823 inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]] CTD PMID:20453393 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [TNF protein results in increased activity of CASP3 protein]] CTD PMID:9388267 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions ISO
EXP
KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog results in increased phosphorylation of TRPC6 protein]; KT 5823 inhibits the reaction [8-bromocyclic GMP results in increased phosphorylation of TRPC6 protein]
KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein]]; KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog results in increased phosphorylation of TRPC6 protein]
CTD PMID:20177073 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link
G Txn1 thioredoxin 1 multiple interactions EXP KT 5823 inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in decreased expression of TXN1 protein]] CTD PMID:20453393 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
KT 5926 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lcp1 lymphocyte cytosolic protein 1 multiple interactions ISO KT 5926 inhibits the reaction [calyculin A results in increased phosphorylation of LCP1 protein]; KT 5926 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of LCP1 protein] CTD PMID:14769871 NCBI chr15:57,170,566...57,277,811
Ensembl chr15:57,221,292...57,277,811
JBrowse link
midostaurin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO midostaurin results in decreased activity of ABCB1 protein CTD PMID:11836167 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Agt angiotensinogen multiple interactions EXP midostaurin inhibits the reaction [AGT protein results in increased abundance of Epoprostenol] CTD PMID:14613874 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions
decreases activity
ISO midostaurin inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Daunorubicin]; midostaurin inhibits the reaction [AKR1C3 protein results in increased metabolism of Daunorubicin]
midostaurin results in decreased activity of AKR1C3 protein
CTD PMID:33025066 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Casp3 caspase 3 multiple interactions ISO midostaurin promotes the reaction [Loratadine results in increased activity of CASP3 protein]; midostaurin promotes the reaction [Terfenadine results in increased activity of CASP3 protein] CTD PMID:20570632 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Egf epidermal growth factor multiple interactions ISO midostaurin inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]] CTD PMID:15542774 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases activity ISO midostaurin results in decreased activity of FGFR3 protein CTD PMID:16091734 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases response to substance
decreases activity
ISO FLT3 protein results in decreased susceptibility to midostaurin
midostaurin results in decreased activity of FLT3 protein
CTD PMID:21980431 NCBI chr12:9,360,439...9,437,004
Ensembl chr12:9,360,672...9,436,570
JBrowse link
G Gypa glycophorin A decreases expression ISO midostaurin results in decreased expression of GYPA protein CTD PMID:19573588 NCBI chr19:31,115,545...31,131,079 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO midostaurin inhibits the reaction [KIT protein polymorphism results in increased expression of HMOX1 protein] CTD PMID:17420286 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO midostaurin results in increased expression of and results in increased localization of ITGB3 protein CTD PMID:19573588 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO midostaurin inhibits the reaction [KIT protein polymorphism results in increased expression of HMOX1 protein] CTD PMID:17420286 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO midostaurin affects the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein] CTD PMID:15542774 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO midostaurin affects the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein] CTD PMID:15542774 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mpl MPL proto-oncogene, thrombopoietin receptor increases expression ISO midostaurin results in increased expression of MPL protein CTD PMID:19573588 NCBI chr 5:137,268,412...137,282,032
Ensembl chr 5:137,269,480...137,281,298
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP midostaurin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:14613874 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO midostaurin affects the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]; midostaurin inhibits the reaction [EGF protein inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]] CTD PMID:15542774 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
staurosporine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Staurosporine results in decreased activity of ABCB11 protein CTD PMID:20829430 PMID:23956101 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Ache acetylcholinesterase multiple interactions
increases expression
increases activity
ISO ACHE protein affects the susceptibility to [Staurosporine results in increased activity of CASP9 protein]
Staurosporine results in increased expression of ACHE protein alternative form
Staurosporine results in increased activity of ACHE protein
CTD PMID:20338155 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Adm adrenomedullin decreases expression ISO Staurosporine results in decreased expression of ADM mRNA CTD PMID:19253104 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]
Staurosporine results in increased phosphorylation of AKT1 protein
Staurosporine promotes the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]
CTD PMID:11306697 PMID:15177934 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Staurosporine inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; Staurosporine promotes the reaction [PSEN2 protein mutant form results in increased expression of APP protein] CTD PMID:12556443 PMID:18001288 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Ar androgen receptor multiple interactions ISO Staurosporine binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atg12 autophagy related 12 affects response to substance ISO ATG12 protein affects the susceptibility to Staurosporine CTD PMID:16497721 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Atg7 autophagy related 7 affects response to substance ISO ATG7 protein affects the susceptibility to Staurosporine CTD PMID:16497721 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 decreases expression EXP Staurosporine results in decreased expression of ATP2A2 mRNA CTD PMID:10625299 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Bag3 BAG cochaperone 3 decreases response to substance
decreases expression
multiple interactions
ISO BAG3 protein results in decreased susceptibility to Staurosporine
Staurosporine results in decreased expression of BAG3 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Staurosporine results in increased degradation of BAG3 protein]; Staurosporine results in increased degradation of and results in increased ubiquitination of BAG3 protein
CTD PMID:19352495 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Bag4 BAG cochaperone 4 decreases expression ISO Staurosporine results in decreased expression of BAG4 protein CTD PMID:19352495 NCBI chr16:71,057,709...71,075,874
Ensembl chr16:71,058,022...71,075,320
JBrowse link
G Bag6 BAG cochaperone 6 decreases expression ISO Staurosporine results in decreased expression of BAG6 protein CTD PMID:19352495 NCBI chr20:5,124,512...5,138,084
Ensembl chr20:5,125,349...5,138,084
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects localization
affects expression
increases expression
ISO
EXP
Staurosporine affects the folding of and results in increased activity of BAX protein; Staurosporine promotes the reaction [BID protein binds to BAX protein]; Staurosporine results in increased activity of and results in increased expression of BAX protein
Staurosporine affects the localization of BAX protein
Staurosporine affects the expression of BAX mRNA
Tacrine inhibits the reaction [Staurosporine results in increased expression of BAX protein]
CTD PMID:11296547 PMID:12579951 PMID:15961378 PMID:16007140 PMID:19552762 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Staurosporine inhibits the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein] CTD PMID:15907805 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases response to substance
increases expression
affects expression
ISO
EXP
BCL2L1 protein results in decreased susceptibility to Staurosporine
Staurosporine results in increased expression of BCL2L1 protein alternative form
Staurosporine affects the expression of BCL2L1 mRNA
BCL2L1 gene mutant form results in decreased susceptibility to Staurosporine
CTD PMID:10679475 PMID:10970895 PMID:11296547 PMID:11468182 PMID:21256112 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Becn1 beclin 1 multiple interactions
decreases response to substance
ISO 3-methyladenine inhibits the reaction [BECN1 protein results in decreased susceptibility to Staurosporine] CTD PMID:16497721 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bid BH3 interacting domain death agonist increases expression
multiple interactions
ISO Staurosporine results in increased expression of BID protein
Staurosporine promotes the reaction [BID protein binds to BAX protein]
CTD PMID:19552762 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases response to substance ISO BIRC3 protein results in decreased susceptibility to Staurosporine CTD PMID:16144937 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Staurosporine results in decreased expression of BIRC5 protein CTD PMID:16225760 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B affects expression ISO Staurosporine affects the expression of BUB1B mRNA CTD PMID:15721199 NCBI chr 3:110,367,949...110,420,471
Ensembl chr 3:110,367,939...110,420,458
JBrowse link
G Casp1 caspase 1 multiple interactions
increases activity
affects localization
ISO Nicotine affects the reaction [Staurosporine affects the localization of CASP1 protein]; Nicotine inhibits the reaction [Staurosporine results in increased activity of CASP1 protein] CTD PMID:16927020 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp2 caspase 2 increases cleavage ISO Staurosporine results in increased cleavage of CASP2 protein CTD PMID:10663630 PMID:26124276 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases cleavage
increases secretion
increases activity
ISO
EXP
Acetaminophen promotes the reaction [Staurosporine results in increased activity of CASP3 protein]; DOCK1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; ELMO1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; EOMES protein inhibits the reaction [Staurosporine results in increased expression of CASP3 protein modified form]; ginkgolide B inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]; Lithium Chloride inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; Memantine inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]]; PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]; quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]; Rifampin inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]; Staurosporine results in increased cleavage of and results in increased activity of CASP3 protein; Thiopental inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; Valproic Acid inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]
Staurosporine results in increased secretion of CASP3 protein
3-methyladenine promotes the reaction [Staurosporine results in increased cleavage of CASP3 protein]; EGF protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; HR protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; Ibuprofen inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; IGF1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; nimesulide inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; Sirolimus inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]
HR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]; Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPTAN1 protein]; TRP53 protein affects the reaction [HR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]]; VASP mutant form promotes the reaction [Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPTAN1 protein]]
CTD PMID:10663630 PMID:11296547 PMID:12556443 PMID:12871656 PMID:15909127 PMID:16007152 PMID:16225760 PMID:16402917 PMID:16497721 PMID:17045724 PMID:17051331 PMID:17245372 PMID:17996985 PMID:18178165 PMID:18182247 PMID:18218830 PMID:18832097 PMID:19101580 PMID:19352495 PMID:19406941 PMID:20302886 PMID:20886113 PMID:21534955 PMID:21864672 PMID:24132472 PMID:24260418 PMID:24912781 PMID:25586182 PMID:26124276 PMID:26775663 PMID:26963176 PMID:27392949 PMID:27539959 PMID:28450277 PMID:28747609 PMID:28975372 PMID:29140133 PMID:29410032 PMID:29458164 PMID:30660566 PMID:30905860 PMID:31758921 PMID:31926150 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 increases cleavage ISO Staurosporine results in increased cleavage of CASP6 protein CTD PMID:26124276 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp7 caspase 7 multiple interactions
increases expression
increases cleavage
increases activity
EXP
ISO
EGF protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]; IGF1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]
Staurosporine results in increased expression of CASP7 protein modified form
Staurosporine results in increased cleavage of CASP7 protein
DOCK1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]; ELMO1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]; EOMES protein inhibits the reaction [Staurosporine results in increased expression of CASP7 protein modified form]
CTD PMID:16402917 PMID:18832097 PMID:19352495 PMID:19406941 PMID:21864672 PMID:24912781 PMID:25586182 PMID:26124276 PMID:27539959 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
increases activity
ISO benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Staurosporine results in increased cleavage of CASP8 protein]; Staurosporine results in increased cleavage of and results in increased activity of CASP8 protein
Staurosporine results in increased activity of CASP8 protein
CTD PMID:16007152 PMID:19352495 PMID:24658017 PMID:29458164 PMID:31926150 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
increases activity
ISO
EXP
ACHE protein affects the susceptibility to [Staurosporine results in increased activity of CASP9 protein]; Staurosporine results in increased cleavage of and results in increased activity of CASP9 protein
Staurosporine results in increased cleavage of CASP9 protein
3-methyladenine promotes the reaction [Staurosporine results in increased cleavage of CASP9 protein]; Sirolimus inhibits the reaction [Staurosporine results in increased cleavage of CASP9 protein]
CTD PMID:16007152 PMID:16497721 PMID:19352495 PMID:20338155 PMID:26124276 PMID:29458164 PMID:31730886 PMID:31926150 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 multiple interactions EXP Staurosporine inhibits the reaction [[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of and affects the localization of CCR5 protein] CTD PMID:12594210 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
JBrowse link
G Cd28 Cd28 molecule multiple interactions ISO Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD28 protein] CTD PMID:11465111 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDKN1A protein] CTD PMID:15978937 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO Staurosporine inhibits the reaction [Tretinoin results in increased phosphorylation of CDKN1B protein] CTD PMID:16618747 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions
affects binding
ISO Staurosporine affects the reaction [KT 5720 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]]; Staurosporine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]; Staurosporine promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]
Staurosporine binds to CHRM1 protein
CTD PMID:10860942 PMID:16439611 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO Staurosporine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:10860942 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 affects binding EXP Staurosporine binds to CHRM3 protein CTD PMID:12435818 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Staurosporine inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crh corticotropin releasing hormone multiple interactions EXP Staurosporine inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]] CTD PMID:2153673 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO CSF2 protein affects the susceptibility to [Nitroblue Tetrazolium co-treated with Staurosporine] CTD PMID:8471626 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csn2 casein beta multiple interactions ISO Staurosporine inhibits the reaction [[INS1 protein co-treated with PRL protein] results in increased expression of CSN2 mRNA] CTD PMID:7648427 NCBI chr14:21,972,274...21,979,511
Ensembl chr14:21,972,274...21,979,510
JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 affects expression ISO Staurosporine affects the expression of CSNK2A2 mRNA CTD PMID:15721199 NCBI chr19:9,972,537...10,012,043
Ensembl chr19:9,972,537...10,012,043
JBrowse link
G Ctnnb1 catenin beta 1 increases phosphorylation EXP Staurosporine results in increased phosphorylation of CTNNB1 protein CTD PMID:19741129 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 multiple interactions EXP Staurosporine inhibits the reaction [[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of and affects the localization of CCR5 protein]; Staurosporine inhibits the reaction [[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of CXCR4 protein] CTD PMID:12594210 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions EXP Staurosporine inhibits the reaction [[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of CXCR4 protein] CTD PMID:12594210 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of NOX2 protein] CTD PMID:29183754 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP
Staurosporine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Staurosporine inhibits the reaction [benz(a)anthracene results in increased activity of CYP1A1 protein]; Staurosporine inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Staurosporine inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]
CTD PMID:1312672 PMID:7587946 PMID:9395520 PMID:10696073 PMID:15947024 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
EXP Staurosporine inhibits the reaction [INS1 protein results in decreased expression of CYP2E1 mRNA]
Staurosporine results in increased expression of CYP2E1 mRNA
CTD PMID:11306697 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Staurosporine results in increased expression of DDIT3 mRNA CTD PMID:32870474 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dedd death effector domain-containing affects expression ISO Staurosporine affects the expression of DEDD mRNA CTD PMID:15721199 NCBI chr13:89,706,932...89,721,825
Ensembl chr13:89,718,066...89,721,454
JBrowse link
G Dock1 dedicator of cyto-kinesis 1 multiple interactions ISO DOCK1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; DOCK1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein] CTD PMID:25586182 NCBI chr 1:206,900,617...207,414,852
Ensembl chr 1:206,900,617...207,414,843
JBrowse link
G Edf1 endothelial differentiation-related factor 1 multiple interactions
decreases expression
EXP Staurosporine inhibits the reaction [MBF1 protein results in increased secretion of NPPA protein]
Staurosporine results in decreased expression of MBF1 protein
CTD PMID:12729799 NCBI chr 3:2,781,169...2,785,474
Ensembl chr 3:2,781,169...2,785,474
JBrowse link
G Edn1 endothelin 1 decreases activity EXP Staurosporine results in decreased activity of EDN1 protein CTD PMID:15464066 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP Staurosporine inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]; Staurosporine inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein] CTD PMID:20561571 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Egf epidermal growth factor multiple interactions ISO
EXP
Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]]; Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein]]; Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein]]; Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]]
EGF protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; EGF protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]
CTD PMID:15542774 PMID:19406941 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] CTD PMID:15177934 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 decreases activity ISO Staurosporine results in decreased activity of EIF2AK2 protein CTD PMID:12890478 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Staurosporine results in increased phosphorylation of EIF2S1 protein CTD PMID:21090173 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Elmo1 engulfment and cell motility 1 multiple interactions ISO ELMO1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; ELMO1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein] CTD PMID:25586182 NCBI chr17:46,352,102...46,888,788
Ensembl chr17:46,353,330...46,794,845
JBrowse link
G Eomes eomesodermin multiple interactions ISO EOMES protein inhibits the reaction [Staurosporine results in increased cleavage of PARP1 protein]; EOMES protein inhibits the reaction [Staurosporine results in increased expression of CASP3 protein modified form]; EOMES protein inhibits the reaction [Staurosporine results in increased expression of CASP7 protein modified form] CTD PMID:27539959 NCBI chr 8:127,144,367...127,152,618
Ensembl chr 8:127,144,903...127,151,493
JBrowse link
G Epo erythropoietin decreases response to substance
multiple interactions
EXP EPO protein results in decreased susceptibility to Staurosporine
tin mesoporphyrin inhibits the reaction [EPO protein results in decreased susceptibility to Staurosporine]
CTD PMID:15816862 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease affects expression ISO Staurosporine affects the expression of ERCC5 mRNA CTD PMID:15721199 NCBI chr 9:50,928,847...50,970,962
Ensembl chr 9:50,925,619...50,970,955
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Staurosporine binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Staurosporine binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Staurosporine inhibits the reaction [Asbestos, Crocidolite results in increased expression of F3 mRNA] CTD PMID:15371228 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fermt2 FERM domain containing kindlin 2 affects expression ISO Staurosporine affects the expression of FERMT2 mRNA CTD PMID:15721199 NCBI chr15:19,807,806...19,876,557
Ensembl chr15:19,807,808...19,876,408
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP Staurosporine inhibits the reaction [Acetaldehyde results in increased expression of FN1 mRNA] CTD PMID:7945571 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Staurosporine inhibits the reaction [Acetaldehyde results in increased expression of FOS mRNA]; Staurosporine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA] CTD PMID:7945571 PMID:9417049 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO Staurosporine promotes the reaction [MYC protein binds to GCLC promoter] CTD PMID:17628013 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO Staurosporine promotes the reaction [MYC protein binds to GCLM promoter] CTD PMID:17628013 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein] CTD PMID:21879721 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Grp gastrin releasing peptide multiple interactions ISO Staurosporine promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates] CTD PMID:18313772 NCBI chr18:61,563,458...61,576,818
Ensembl chr18:61,563,053...61,576,818
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions EXP Staurosporine inhibits the reaction [benz(a)anthracene results in increased activity of GSTA2 protein] CTD PMID:7587946 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO Staurosporine inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; Staurosporine inhibits the reaction [Smoke analog results in increased expression of HMOX1 protein]; Staurosporine inhibits the reaction [VEGFA protein results in increased expression of HMOX1 protein]
Staurosporine results in increased expression of HMOX1 protein
SOD2 mutant form inhibits the reaction [Staurosporine results in increased expression of HMOX1 protein]
CTD PMID:12788823 PMID:18048804 PMID:24740755 PMID:28108387 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hr HR, lysine demethylase and nuclear receptor corepressor multiple interactions
affects response to substance
ISO
EXP
HR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]; TRP53 protein affects the reaction [HR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]]
HR protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; HR protein inhibits the reaction [Staurosporine results in increased expression of TP53 protein]
HR protein affects the susceptibility to Staurosporine
CTD PMID:20886113 NCBI chr15:52,241,801...52,261,276
Ensembl chr15:52,241,801...52,261,276
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
affects activity
EXP IGF1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; IGF1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]
Staurosporine affects the activity of IGF1 protein
CTD PMID:11548882 PMID:19406941 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il33 interleukin 33 multiple interactions
increases expression
ISO N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Staurosporine results in increased expression of IL33 protein] CTD PMID:25747661 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Il4 interleukin 4 multiple interactions EXP Staurosporine inhibits the reaction [IL4 protein promotes the reaction [Ionomycin results in increased expression of TNFRSF4 protein]]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [IL4 protein results in increased expression of TNFRSF4 protein]] CTD PMID:9766631 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 decreases activity ISO Staurosporine results in decreased activity of IL5 protein CTD PMID:12562334 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Ins2 insulin 2 multiple interactions EXP Staurosporine inhibits the reaction [INS protein results in increased uptake of cobaltous chloride] CTD PMID:14622148 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Itgal integrin subunit alpha L multiple interactions ISO Staurosporine inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAL mRNA]; Staurosporine inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAL protein]; Staurosporine inhibits the reaction [TNF protein results in increased expression of ITGAL mRNA]; Staurosporine inhibits the reaction [TNF protein results in increased expression of ITGAL protein] CTD PMID:10198263 NCBI chr 1:198,744,053...198,781,745
Ensembl chr 1:198,744,050...198,781,750
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Staurosporine inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGAM protein] CTD PMID:18500357 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein] CTD PMID:16393473 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation
EXP Staurosporine inhibits the reaction [Acetaldehyde results in increased expression of JUN mRNA]
Staurosporine results in increased phosphorylation of JUN protein
CTD PMID:7945571 PMID:9751194 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kng2 kininogen 2 decreases activity EXP Staurosporine results in decreased activity of KNG1 CTD PMID:1334751 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Lmna lamin A/C increases cleavage ISO Staurosporine results in increased cleavage of LMNA protein CTD PMID:26124276 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein]]; Staurosporine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Staurosporine promotes the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein]
Staurosporine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]
Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of MAPK1 protein]
CTD PMID:11035063 PMID:15177934 PMID:15542774 PMID:16251475 PMID:17003101 PMID:19699794 PMID:21879721 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein]]; Staurosporine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Staurosporine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Staurosporine promotes the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein]
Staurosporine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]
Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of MAPK3 protein]
CTD PMID:11035063 PMID:15177934 PMID:15542774 PMID:16251475 PMID:17003101 PMID:19699794 PMID:21879721 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO
EXP
Staurosporine inhibits the reaction [oxophenylarsine results in increased phosphorylation of MAPT protein] CTD PMID:10737602 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mark1 microtubule affinity regulating kinase 1 multiple interactions ISO Staurosporine inhibits the reaction [oxophenylarsine results in increased activity of MARK1 protein] CTD PMID:10737602 NCBI chr13:102,808,254...102,942,863
Ensembl chr13:102,808,253...102,942,863
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases cleavage
decreases response to substance
ISO Staurosporine results in increased cleavage of MCL1 protein
MCL1 results in decreased susceptibility to Staurosporine
CTD PMID:15217956 PMID:16007152 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]] CTD PMID:15542774 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Staurosporine inhibits the reaction [Homocysteine results in increased activity of MMP9 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased expression of MMP9 protein] CTD PMID:16251475 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO Staurosporine inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; Staurosporine inhibits the reaction [Zinc Sulfate results in increased expression of MT1 mRNA] CTD PMID:15142038 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases response to substance
ISO MYC protein inhibits the reaction [Staurosporine results in increased abundance of Reactive Oxygen Species]; Staurosporine promotes the reaction [MYC protein binds to GCLC promoter]; Staurosporine promotes the reaction [MYC protein binds to GCLM promoter]
MYC protein results in decreased susceptibility to Staurosporine
CTD PMID:17628013 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nefl neurofilament light chain multiple interactions EXP Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFL protein] CTD PMID:21879721 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
JBrowse link
G Nefm neurofilament medium chain multiple interactions EXP Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFM protein] CTD PMID:21879721 NCBI chr15:44,855,307...44,860,604
Ensembl chr15:44,855,310...44,860,604
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
decreases expression
ISO Staurosporine inhibits the reaction [Ethanol affects the localization of NFE2L2 protein]; Staurosporine inhibits the reaction [sulforaphane results in increased expression of NFE2L2 protein]
Staurosporine results in decreased expression of NFE2L2 protein modified form
CTD PMID:22530035 PMID:30703377 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Staurosporine inhibits the reaction [bisphenol A results in increased expression of NFKB1 protein] CTD PMID:20499049 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Ngf nerve growth factor multiple interactions ISO
EXP
Staurosporine inhibits the reaction [NGF results in increased susceptibility to Capsaicin]
Staurosporine inhibits the reaction [NGF protein results in increased uptake of Calcium]
CTD PMID:1374475 PMID:12815188 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Staurosporine inhibits the reaction [ginsenoside Rg3 results in increased expression of NOS2 protein] CTD PMID:14534150 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP Staurosporine inhibits the reaction [MBF1 protein results in increased secretion of NPPA protein] CTD PMID:12729799 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP
ISO
Staurosporine inhibits the reaction [benz(a)anthracene results in increased activity of NQO1 protein]
Staurosporine inhibits the reaction [Smoke analog results in increased expression of NQO1 protein]
CTD PMID:7587946 PMID:28108387 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Ntf3 neurotrophin 3 multiple interactions EXP Staurosporine inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Staurosporine inhibits the reaction [imetit results in increased expression of NTF3 protein]; Staurosporine inhibits the reaction [methylhistaprodifen results in increased expression of NTF3 protein]; Staurosporine inhibits the reaction [Neurotransmitter Agents results in increased expression of NTF3 protein] CTD PMID:19854260 PMID:21276809 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886
JBrowse link
G Nts neurotensin multiple interactions
increases activity
ISO Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein]; Staurosporine promotes the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]; Tetradecanoylphorbol Acetate inhibits the reaction [Staurosporine results in increased activity of NTS protein] CTD PMID:15177934 PMID:18313772 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases expression
increases cleavage
ISO
EXP
SOD2 mutant form inhibits the reaction [Staurosporine results in increased cleavage of PARP1 protein]; Staurosporine affects the reaction [sodium arsenite results in increased cleavage of PARP1 protein]
Staurosporine results in increased expression of PARP1 protein modified form
EOMES protein inhibits the reaction [Staurosporine results in increased cleavage of PARP1 protein]
CTD PMID:10704466 PMID:11035063 PMID:18451153 PMID:21447800 PMID:22639866 PMID:24464939 PMID:24740755 PMID:27539959 PMID:30660566 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Staurosporine binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [Hydrogen Peroxide co-treated with Staurosporine] results in increased acetylation of PPARGC1A protein; resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in increased acetylation of PPARGC1A protein] CTD PMID:23293585 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta affects localization EXP Staurosporine affects the localization of PPP2R2B protein CTD PMID:18940801 NCBI chr18:36,985,709...37,421,383
Ensembl chr18:36,985,714...37,245,809
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha decreases response to substance
increases cleavage
ISO PPP3CA protein results in decreased susceptibility to Staurosporine
Staurosporine results in increased cleavage of PPP3CA protein
CTD PMID:10679475 PMID:10898953 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO Staurosporine inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein] CTD PMID:11796722 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO
EXP
Staurosporine affects the localization of and affects the activity of PRKCA protein
[linsidomine co-treated with Staurosporine] results in decreased expression of PRKCA protein; Staurosporine inhibits the reaction [Heptachlor affects the localization of PRKCA protein]; Staurosporine inhibits the reaction [linsidomine results in increased phosphorylation of PRKCA protein]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]
CTD PMID:11994256 PMID:14678745 PMID:16225760 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO
EXP
Staurosporine inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]
Staurosporine inhibits the reaction [Heptachlor affects the localization of PRKCD protein]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein]
CTD PMID:14678745 PMID:17171638 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prl prolactin multiple interactions ISO Staurosporine inhibits the reaction [[INS1 protein co-treated with PRL protein] results in increased expression of CSN2 mRNA] CTD PMID:7648427 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Psen2 presenilin 2 multiple interactions ISO pifithrin inhibits the reaction [PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]]; PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]; Staurosporine promotes the reaction [PSEN2 protein mutant form results in increased expression of APP protein] CTD PMID:12556443 NCBI chr13:98,513,600...98,539,347
Ensembl chr13:98,513,570...98,530,724
JBrowse link
G Ptger3 prostaglandin E receptor 3 multiple interactions
decreases phosphorylation
EXP Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PTGER3 protein alternative form]
Staurosporine results in decreased phosphorylation of PTGER3 protein alternative form
CTD PMID:15937517 NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698
JBrowse link
G Ptges3 prostaglandin E synthase 3 increases cleavage ISO Staurosporine results in increased cleavage of PTGES3 protein CTD PMID:26124276 NCBI chr 7:2,479,267...2,497,024
Ensembl chr 7:2,479,311...2,497,013
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Staurosporine inhibits the reaction [Nicotine results in increased expression of PTGS2] CTD PMID:17003101 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Staurosporine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]; Staurosporine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
Staurosporine inhibits the reaction [bisphenol A results in increased expression of RELA protein]
CTD PMID:20499049 PMID:24021941 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ret ret proto-oncogene decreases expression EXP Staurosporine results in decreased expression of RET protein CTD PMID:17555550 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372
JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B multiple interactions ISO [Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SDHB protein; resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SDHB protein] CTD PMID:23293585 NCBI chr 5:159,484,378...159,505,063
Ensembl chr 5:159,484,370...159,505,064
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO [Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SIRT1 protein; resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SIRT1 protein] CTD PMID:23293585 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions
decreases phosphorylation
ISO [Staurosporine results in decreased phosphorylation of SLC11A2 protein] which results in decreased uptake of Iron CTD PMID:27681840 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Slc12a5 solute carrier family 12 member 5 increases activity
multiple interactions
ISO Staurosporine results in increased activity of SLC12A5 protein
Staurosporine inhibits the reaction [SLC12A5 protein results in increased import of Thallium]
CTD PMID:20086212 NCBI chr 3:161,433,303...161,465,078
Ensembl chr 3:161,425,988...161,462,879
JBrowse link
G Slc1a1 solute carrier family 1 member 1 multiple interactions
decreases activity
EXP Staurosporine inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]; Staurosporine inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]
Staurosporine results in decreased activity of SLC1A1 protein
CTD PMID:17382927 PMID:22511482 PMID:23262392 PMID:23602688 PMID:24355585 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions EXP Staurosporine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC1A2 protein] CTD PMID:26988466 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc22a25 solute carrier family 22, member 25 multiple interactions ISO Staurosporine inhibits the reaction [Phorbol 12,13-Dibutyrate affects the localization of SLC22A9 protein]; Staurosporine inhibits the reaction [Phorbol 12,13-Dibutyrate results in decreased activity of SLC22A9 protein] CTD PMID:17341544 NCBI chr 1:224,596,886...224,698,512
Ensembl chr 1:224,596,887...224,698,514
JBrowse link
G Slc30a1 solute carrier family 30 member 1 multiple interactions ISO Staurosporine inhibits the reaction [Zinc Sulfate results in increased expression of SLC30A1 mRNA] CTD PMID:15142038 NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683
JBrowse link
G Slc5a6 solute carrier family 5 member 6 multiple interactions ISO Staurosporine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] CTD PMID:15561972 NCBI chr 6:26,685,823...26,697,110
Ensembl chr 6:26,686,033...26,697,116
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
increases activity
ISO SNCA protein affects the reaction [Staurosporine results in increased activity of SLC6A3 protein] CTD PMID:19032594 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slc6a4 solute carrier family 6 member 4 increases activity ISO staurosporine increases activity of SLC6A4 protein in placental choriocarcinoma cells RGD PMID:7615516 RGD:38500207 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Snca synuclein alpha multiple interactions ISO [Staurosporine co-treated with Rotenone] promotes the reaction [SNCA protein binds to SNCA protein]; SNCA protein affects the reaction [Staurosporine results in increased activity of SLC6A3 protein] CTD PMID:19032594 PMID:19114014 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SOD2 protein; resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SOD2 protein]; SOD2 mutant form inhibits the reaction [Staurosporine results in increased cleavage of PARP1 protein]; SOD2 mutant form inhibits the reaction [Staurosporine results in increased expression of HMOX1 protein] CTD PMID:23293585 PMID:24740755 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 multiple interactions
increases cleavage
ISO Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPTAN1 protein]; VASP mutant form promotes the reaction [Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPTAN1 protein]]
Staurosporine results in increased cleavage of SPTAN1 protein
CTD PMID:18182247 PMID:21683092 PMID:26124276 NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] CTD PMID:18448488 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein multiple interactions ISO Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of SYNCRIP protein] CTD PMID:19331829 NCBI chr 8:96,100,692...96,266,342
Ensembl chr 8:96,105,025...96,266,342
JBrowse link
G Tert telomerase reverse transcriptase decreases activity ISO Staurosporine results in decreased activity of TERT protein CTD PMID:9434777 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Staurosporine binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Staurosporine binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP Staurosporine inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein] CTD PMID:16716901 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Staurosporine inhibits the reaction [TNF protein results in increased expression of ITGAL mRNA]; Staurosporine inhibits the reaction [TNF protein results in increased expression of ITGAL protein] CTD PMID:10198263 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf4 TNF receptor superfamily member 4 multiple interactions
increases expression
EXP Staurosporine inhibits the reaction [IL4 protein promotes the reaction [Ionomycin results in increased expression of TNFRSF4 protein]]; Staurosporine inhibits the reaction [Ionomycin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFRSF4 protein]]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [IL4 protein results in increased expression of TNFRSF4 protein]]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFRSF4 protein]; Staurosporine promotes the reaction [Mercuric Chloride results in increased expression of TNFRSF4 protein]
Staurosporine results in increased expression of TNFRSF4 protein
CTD PMID:9766631 NCBI chr 5:173,447,784...173,450,474
Ensembl chr 5:173,447,784...173,450,474
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO
EXP
Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]]; Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]]; Staurosporine promotes the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]
TRP53 protein affects the reaction [HR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]]
HR protein inhibits the reaction [Staurosporine results in increased expression of TP53 protein]
CTD PMID:15542774 PMID:20886113 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions ISO VASP mutant form promotes the reaction [Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPTAN1 protein]] CTD PMID:18182247 NCBI chr 1:80,170,608...80,185,882
Ensembl chr 1:80,170,619...80,185,882
JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions EXP 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Staurosporine promotes the reaction [VDAC1 protein binds to VDAC1 protein]]; Staurosporine promotes the reaction [VDAC1 protein binds to VDAC1 protein] CTD PMID:20937774 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
JBrowse link
G Vdr vitamin D receptor increases cleavage ISO Staurosporine results in increased cleavage of VDR protein CTD PMID:18832097 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Staurosporine inhibits the reaction [VEGFA protein results in increased abundance of phosphatidylbutanol]; Staurosporine inhibits the reaction [VEGFA protein results in increased expression of HMOX1 protein] CTD PMID:12788823 PMID:14704231 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin multiple interactions EXP Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of VIM protein] CTD PMID:21879721 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Wt1 WT1 transcription factor increases expression ISO Staurosporine results in increased expression of WT1 protein CTD PMID:12914969 NCBI chr 3:95,133,221...95,180,574
Ensembl chr 3:95,133,713...95,180,564
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19786
    chemical entity 19786
      atom 19784
        nonmetal atom 19666
          carbon atom 19586
            organic molecular entity 19586
              heteroorganic entity 19226
                organic heterocyclic compound 18574
                  organic heteropolycyclic compound 18065
                    organic heterooctacyclic compound 194
                      7-oxo-3,8,9-trihydroxy staurosporine 0
                      7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine 0
                      K-252a + 43
                      KT 5720 43
                      KT 5823 27
                      KT 5926 1
                      TTT-3002 0
                      linkable staurosporine analogue 0
                      midostaurin 16
                      staurosporine + 155
                      terpendole K 0
                      terpendole L 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19596
                        carbon atom 19586
                          organic molecular entity 19586
                            organic molecule 19519
                              organic cyclic compound 19349
                                organic heterocyclic compound 18574
                                  organic heteropolycyclic compound 18065
                                    organic heterooctacyclic compound 194
                                      7-oxo-3,8,9-trihydroxy staurosporine 0
                                      7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine 0
                                      K-252a + 43
                                      KT 5720 43
                                      KT 5823 27
                                      KT 5926 1
                                      TTT-3002 0
                                      linkable staurosporine analogue 0
                                      midostaurin 16
                                      staurosporine + 155
                                      terpendole K 0
                                      terpendole L 0
paths to the root