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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:19-oxo steroid
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Accession:CHEBI:38149 term browser browse the term
Synonyms:related_synonym: 19-oxo steroids


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andrastin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf2 colony stimulating factor 2 multiple interactions ISO andrastin A results in increased expression of and results in increased secretion of CSF2 protein CTD PMID:28535995 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO andrastin A results in increased expression of and results in increased secretion of TGFB1 protein CTD PMID:28535995 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO andrastin A results in increased expression of and results in increased secretion of TNF protein CTD PMID:28535995 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
hellebrigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO hellebrigenin results in decreased phosphorylation of and results in decreased expression of AKT1 protein CTD PMID:24954031 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atm ATM serine/threonine kinase increases phosphorylation ISO hellebrigenin results in increased phosphorylation of ATM protein CTD PMID:24954031 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization ISO hellebrigenin affects the localization of BAX protein CTD PMID:24954031 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO hellebrigenin results in increased expression of CCNB1 protein CTD PMID:24954031 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdc25c cell division cycle 25C decreases phosphorylation ISO hellebrigenin results in decreased phosphorylation of CDC25C protein CTD PMID:24954031 NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases phosphorylation ISO hellebrigenin results in increased phosphorylation of CDK1 protein CTD PMID:24954031 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation ISO hellebrigenin results in increased phosphorylation of CHEK2 protein CTD PMID:24954031 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases activity ISO hellebrigenin results in increased activity of PARP1 protein CTD PMID:24954031 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
helveticoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rorc RAR-related orphan receptor C increases expression ISO helveticoside results in increased expression of RORC mRNA CTD PMID:29981919 NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
strophanthidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport ISO ABCB1 protein results in increased transport of Strophanthidin CTD PMID:26708294 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 increases expression
multiple interactions 		ISO Strophanthidin results in increased expression of G6PC1 mRNA
Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter] 		CTD PMID:29981919 NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO Strophanthidin results in increased expression of and results in increased secretion of IL17A protein CTD PMID:29981919 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il17f interleukin 17F multiple interactions ISO Strophanthidin results in increased expression of and results in increased secretion of IL17F protein CTD PMID:29981919 NCBI chr 9:30,686,532...30,697,918
Ensembl chr 9:23,190,100...23,201,482 		JBrowse link
G Npas2 neuronal PAS domain protein 2 increases expression
multiple interactions 		ISO Strophanthidin results in increased expression of NPAS2 mRNA
Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter] 		CTD PMID:29981919 NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320 		JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions
increases expression 		ISO RORC protein promotes the reaction [Strophanthidin results in increased expression of RORC mRNA]; Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]; Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter] CTD PMID:29981919 NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    chemical entity 20854
      group 20798
        inorganic group 20297
          oxo group 19435
            organic oxo compound 19435
              carbonyl compound 19435
                ketone 17451
                  oxo steroid 10638
                    19-oxo steroid 17
                      (2S,4aR,4bR,6aS,12bS,12cS,14aS)-4a-demethylpaspaline-4a-carboxylic acid 0
                      19-oxo-5alpha-dihydrotestosterone 0
                      3,17-dioxoandrost-4-en-19-al 0
                      3-deacetylated andrastin A 0
                      3beta-[(O-beta-D-glucopyranosyl-(1->3)-4,6-dideoxy-2-O-methyl-beta-D-gulopyranosyl)]-5beta,14beta-dihydroxy-19-oxocard-20(22)enolide 0
                      Atlantinone B 0
                      Botrysphin D 0
                      Botrysphin F 0
                      Drechmerin B 0
                      Drechmerin C 0
                      Lolicine B 0
                      Lolicine-B 11-O-propionate 0
                      Paspaline B 0
                      Terpendole G 0
                      adonitoxigenin + 0
                      andrastin A 3
                      bryotoxin A 0
                      cannogenin + 0
                      convallatoxin 0
                      erysimoside 0
                      hellebrigenin + 8
                      strophanthidin + 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbonyl compound 19435
                                    ketone 17451
                                      oxo steroid 10638
                                        19-oxo steroid 17
                                          (2S,4aR,4bR,6aS,12bS,12cS,14aS)-4a-demethylpaspaline-4a-carboxylic acid 0
                                          19-oxo-5alpha-dihydrotestosterone 0
                                          3,17-dioxoandrost-4-en-19-al 0
                                          3-deacetylated andrastin A 0
                                          3beta-[(O-beta-D-glucopyranosyl-(1->3)-4,6-dideoxy-2-O-methyl-beta-D-gulopyranosyl)]-5beta,14beta-dihydroxy-19-oxocard-20(22)enolide 0
                                          Atlantinone B 0
                                          Botrysphin D 0
                                          Botrysphin F 0
                                          Drechmerin B 0
                                          Drechmerin C 0
                                          Lolicine B 0
                                          Lolicine-B 11-O-propionate 0
                                          Paspaline B 0
                                          Terpendole G 0
                                          adonitoxigenin + 0
                                          andrastin A 3
                                          bryotoxin A 0
                                          cannogenin + 0
                                          convallatoxin 0
                                          erysimoside 0
                                          hellebrigenin + 8
                                          strophanthidin + 6
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