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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dialdehyde
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Accession:CHEBI:38124 term browser browse the term
Definition:Any aldehyde with two aldehyde groups.
Synonyms:related_synonym: bialdehyde;   bialdehydes;   dialdehydes


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fumaraldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP 1-phenylimidazole inhibits the reaction [[[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde]; [[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde; [CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde CTD PMID:21842885 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases secretion ISO FGF1 protein results in decreased secretion of malealdehyde CTD PMID:16222742 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Txn1 thioredoxin 1 decreases activity ISO malealdehyde results in decreased activity of TXN1 protein CTD PMID:27402187 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
glutaraldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 increases expression ISO Glutaral results in increased expression of ATF4 mRNA CTD PMID:28236482 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Casp8 caspase 8 decreases expression ISO Glutaral results in decreased expression of CASP8 mRNA CTD PMID:28236482 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Glutaral results in increased expression of CCL4 mRNA CTD PMID:20713136 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Cd86 CD86 molecule increases expression ISO Glutaral results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity ISO Glutaral results in decreased activity of G6PD protein CTD PMID:19490936 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression EXP Glutaral results in decreased expression of GJA1 protein CTD PMID:19932693 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
multiple interactions
ISO Glutaral results in decreased activity of GSR protein
Idarubicin promotes the reaction [Glutaral results in decreased activity of GSR protein]
CTD PMID:19490936 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Il1r2 interleukin 1 receptor type 2 increases expression ISO Glutaral results in increased expression of IL1R2 mRNA CTD PMID:20713136 NCBI chr 9:46,840,646...46,881,241
Ensembl chr 9:46,840,992...46,881,264
JBrowse link
G Il6 interleukin 6 affects expression ISO Glutaral affects the expression of IL6 mRNA CTD PMID:20200221 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Glutaral results in increased expression of PMAIP1 mRNA CTD PMID:20713136 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Tnf tumor necrosis factor affects expression
increases expression
ISO Glutaral affects the expression of TNF mRNA
Glutaral results in increased expression of TNF mRNA
CTD PMID:20200221, PMID:28236482 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO Glutaral results in decreased expression of TP53 mRNA CTD PMID:28236482 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
glyoxal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases degradation
ISO Glyoxal inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]
Glyoxal results in increased degradation of ABCA1 protein
Glyoxal inhibits the reaction [ABCA1 protein binds to APOA1 protein]
CTD PMID:15983222 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases reduction ISO AKR1B1 protein results in increased reduction of Glyoxal CTD PMID:10510318 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of Glyoxal CTD PMID:18845131 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases activity
increases expression
ISO Glyoxal results in increased activity of AKR1C2 promoter
Glyoxal results in increased expression of AKR1C2 mRNA
CTD PMID:21195160, PMID:25724174 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions EXP [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal CTD PMID:21334317 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO Glyoxal inhibits the reaction [ABCA1 protein binds to APOA1 protein] CTD PMID:15983222 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Glyoxal results in increased expression of ATF3 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Camp cathelicidin antimicrobial peptide multiple interactions
increases expression
EXP Glyoxal promotes the reaction [Capsaicin results in increased expression of CAMP protein]
Glyoxal results in increased expression of CAMP protein
CTD PMID:29496360 NCBI chr 8:117,930,557...117,932,371
Ensembl chr 8:117,930,546...117,932,518
JBrowse link
G Cat catalase decreases response to substance EXP CAT protein results in decreased susceptibility to Glyoxal CTD PMID:21334317 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO Glyoxal results in decreased expression of COL1A1 mRNA CTD PMID:28760545 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Ctss cathepsin S decreases activity ISO Glyoxal results in decreased activity of CTSS protein CTD PMID:16671891 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
JBrowse link
G Defb2 defensin beta 2 multiple interactions
increases expression
EXP Glyoxal promotes the reaction [Capsaicin results in increased expression of DEFB2 protein]
Glyoxal results in increased expression of DEFB2 protein
CTD PMID:29496360 NCBI chr16:75,227,468...75,241,303
Ensembl chr16:75,227,468...75,241,303
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Glyoxal results in increased expression of DNAJB4 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Glyoxal results in increased expression of GCLM mRNA CTD PMID:27965148 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Glyoxal results in increased expression of HMOX1 mRNA CTD PMID:23445166, PMID:25724174 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO Glyoxal results in increased expression of HSPH1 mRNA CTD PMID:23999411 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Ifng interferon gamma multiple interactions EXP [Capsaicin results in increased susceptibility to Glyoxal] which results in increased expression of IFNG mRNA CTD PMID:29496360 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il18 interleukin 18 increases expression ISO Glyoxal results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il6 interleukin 6 affects expression ISO Glyoxal analog affects the expression of IL6 mRNA CTD PMID:20200221 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Glyoxal promotes the reaction [MAPT protein binds to MAPT protein] CTD PMID:17082178 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Capsaicin results in increased susceptibility to Glyoxal] which results in increased expression of TNF mRNA CTD PMID:29496360 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Glyoxal results in increased expression of TXNRD1 mRNA CTD PMID:23445166 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
malonaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO iron(II)-ascorbic acid complex promotes the reaction [Malondialdehyde results in increased expression of ABCA1 protein] CTD PMID:17070507 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO [ABCB1A mutant form co-treated with triptolide] results in increased abundance of Malondialdehyde CTD PMID:26134275 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression EXP Malondialdehyde results in increased expression of ACTA2 protein CTD PMID:7593635 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Agt angiotensinogen increases abundance
multiple interactions
affects binding
EXP
ISO
AGT protein results in increased abundance of Malondialdehyde
AGT protein modified form results in increased abundance of Malondialdehyde
FNDC5 protein inhibits the reaction [AGT protein modified form results in increased abundance of Malondialdehyde]
Malondialdehyde binds to AGT protein modified form
Atorvastatin inhibits the reaction [AGT protein results in increased abundance of Malondialdehyde]; isorhapontigenin inhibits the reaction [AGT protein results in increased abundance of Malondialdehyde]
CTD PMID:15607907, PMID:19451411, PMID:26111765, PMID:30354818, PMID:30703374 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Alb albumin multiple interactions ISO ALB protein affects the reaction [[Iron co-treated with Bicarbonates] results in increased abundance of Malondialdehyde]; ALB protein inhibits the reaction [[Iron co-treated with Phosphates] results in increased abundance of Malondialdehyde] CTD PMID:16027354 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases metabolic processing
increases oxidation
ISO ALDH1A1 protein results in increased metabolism of Malondialdehyde
ALDH1A1 protein results in increased oxidation of Malondialdehyde
CTD PMID:21256123, PMID:22339434 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member increases oxidation ISO ALDH2 protein results in increased oxidation of Malondialdehyde CTD PMID:22339434 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases metabolic processing ISO ALDH3A1 protein results in increased metabolism of Malondialdehyde CTD PMID:21256123 NCBI chr10:47,490,168...47,499,855
Ensembl chr10:47,490,153...47,499,876
JBrowse link
G Aldh3b1 aldehyde dehydrogenase 3 family, member B1 affects binding ISO Malondialdehyde binds to ALDH3B1 protein CTD PMID:20699116 NCBI chr 1:219,145,457...219,181,536
Ensembl chr 1:219,145,459...219,186,860
JBrowse link
G Apc APC regulator of WNT signaling pathway affects abundance
multiple interactions
ISO APC protein affects the abundance of Malondialdehyde
bis(2-guanidinoethyl)disulfide inhibits the reaction [APC protein affects the abundance of Malondialdehyde]; FeCl tetrakis-2-(triethyleneglycolmonomethylether)pyridylporphyrin inhibits the reaction [APC protein affects the abundance of Malondialdehyde]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [APC protein affects the abundance of Malondialdehyde]
CTD PMID:15063141 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases abundance
ISO vitexin inhibits the reaction [APP protein modified form results in increased abundance of Malondialdehyde] CTD PMID:29545167 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Atp7b ATPase copper transporting beta increases abundance EXP ATP7B gene mutant form results in increased abundance of Malondialdehyde CTD PMID:17303181 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Cat catalase decreases abundance
multiple interactions
EXP CAT protein modified form results in decreased abundance of Malondialdehyde
[SOD1 protein modified form co-treated with CAT protein modified form] results in decreased abundance of Malondialdehyde
CTD PMID:21600015 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO iron(II)-ascorbic acid complex promotes the reaction [Malondialdehyde results in increased expression of CD36 protein] CTD PMID:17070507 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO Malondialdehyde results in decreased expression of COL1A1 mRNA CTD PMID:28760545 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression
multiple interactions
EXP Malondialdehyde results in increased expression of COL1A2 mRNA
MAPK8 protein promotes the reaction [Malondialdehyde results in increased expression of COL1A2 mRNA]
CTD PMID:11295527 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Cp ceruloplasmin affects abundance ISO CP protein affects the abundance of Malondialdehyde CTD PMID:12572680 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Cybb cytochrome b-245 beta chain increases abundance ISO CYBB protein results in increased abundance of Malondialdehyde CTD PMID:19417757 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases expression EXP Malondialdehyde results in decreased expression of EEF2 protein CTD PMID:16469450 NCBI chr 7:11,401,501...11,406,771
Ensembl chr 7:11,401,501...11,406,771
JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 multiple interactions ISO [lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased abundance of Malondialdehyde CTD PMID:25411909 NCBI chr12:12,749,026...12,782,078
Ensembl chr12:12,748,785...12,782,146
JBrowse link
G Epo erythropoietin decreases abundance ISO EPO protein results in decreased abundance of Malondialdehyde CTD PMID:22013135 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Fndc5 fibronectin type III domain containing 5 multiple interactions ISO FNDC5 protein inhibits the reaction [AGT protein modified form results in increased abundance of Malondialdehyde] CTD PMID:30703374 NCBI chr 5:147,323,240...147,330,266
Ensembl chr 5:147,323,240...147,330,266
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO FOXO3 protein inhibits the reaction [SRT1720 inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Malondialdehyde]] CTD PMID:24633890 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit affects abundance ISO GCLM gene polymorphism affects the abundance of Malondialdehyde CTD PMID:25728017 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide decreases abundance EXP GHRL results in decreased abundance of Malondialdehyde CTD PMID:16868036 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
JBrowse link
G Gjb1 gap junction protein, beta 1 decreases abundance ISO GJB1 protein results in decreased abundance of Malondialdehyde CTD PMID:27859493 NCBI chr  X:71,272,030...71,279,973
Ensembl chr  X:71,272,042...71,279,977
JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects abundance ISO GSTT1 gene polymorphism affects the abundance of Malondialdehyde CTD PMID:25728017 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) decreases activity ISO Malondialdehyde results in decreased activity of H6PD protein CTD PMID:20211231 NCBI chr 5:166,994,683...167,030,441
Ensembl chr 5:166,998,881...167,030,441
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in increased abundance of Malondialdehyde]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in increased abundance of Malondialdehyde]] CTD PMID:15602829 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Trichloroethylene co-treated with Malondialdehyde analog] results in increased expression of IFNG protein CTD PMID:18267128 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases abundance ISO IL1RN protein results in decreased abundance of Malondialdehyde CTD PMID:18474811 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Trichloroethylene co-treated with Malondialdehyde analog] results in increased expression of IL2 protein CTD PMID:18267128 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Kl Klotho multiple interactions
increases abundance
ISO Amino Acids inhibits the reaction [KL gene mutant form results in increased abundance of Malondialdehyde]; H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in increased abundance of Malondialdehyde]] CTD PMID:25309793 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP MAPK8 protein promotes the reaction [Malondialdehyde results in increased expression of COL1A2 mRNA] CTD PMID:11295527 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Malondialdehyde promotes the reaction [MAPT protein binds to MAPT protein] CTD PMID:17082178 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mical2 microtubule associated monooxygenase, calponin and LIM domain containing 2 multiple interactions ISO MICAL2 mRNA promotes the reaction [Carbon Tetrachloride results in increased abundance of Malondialdehyde] CTD PMID:32659284 NCBI chr 1:177,048,607...177,173,729
Ensembl chr 1:177,048,655...177,173,995
JBrowse link
G Mir141 microRNA 141 increases abundance ISO MIR141 mRNA results in increased abundance of Malondialdehyde CTD PMID:26548909 NCBI chr 4:157,236,346...157,236,439
Ensembl chr 4:157,236,346...157,236,439
JBrowse link
G Mir3545 microRNA 3545 multiple interactions ISO MIR203 mRNA inhibits the reaction [Carbon Tetrachloride results in increased abundance of Malondialdehyde] CTD PMID:32659284 NCBI chr 6:136,704,947...136,705,061
Ensembl chr 6:136,704,947...136,705,061
JBrowse link
G Myb MYB proto-oncogene, transcription factor increases expression EXP Malondialdehyde results in increased expression of MYB protein CTD PMID:7593635 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO NFE2L2 protein inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Malondialdehyde] CTD PMID:24633890 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO Malondialdehyde results in decreased expression of NOS2 protein CTD PMID:20940037 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO PON1 protein inhibits the reaction [Carbon Tetrachloride results in increased abundance of Malondialdehyde] CTD PMID:20079818 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Pon3 paraoxonase 3 multiple interactions ISO PON3 protein inhibits the reaction [Carbon Tetrachloride results in increased abundance of Malondialdehyde] CTD PMID:20079818 NCBI chr 4:30,311,981...30,338,679
Ensembl chr 4:30,311,982...30,338,679
JBrowse link
G Pten phosphatase and tensin homolog increases abundance ISO PTEN mutant form results in increased abundance of Malondialdehyde CTD PMID:26548909 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions ISO SHC1 protein promotes the reaction [Carbon Tetrachloride results in increased abundance of Malondialdehyde] CTD PMID:32659284 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO SIRT1 protein inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Malondialdehyde] CTD PMID:24633890 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases abundance
EXP [SOD1 protein modified form co-treated with CAT protein modified form] results in decreased abundance of Malondialdehyde
SOD1 protein modified form results in decreased abundance of Malondialdehyde
CTD PMID:21600015 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases abundance
ISO delphinidin inhibits the reaction [TGFB1 results in increased abundance of Malondialdehyde] CTD PMID:30365941 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases abundance
ISO Acetylcysteine inhibits the reaction [TNF results in increased abundance of Malondialdehyde] CTD PMID:17026986 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases mutagenesis ISO Malondialdehyde results in increased mutagenesis of TP53 gene CTD PMID:30658077 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
phthalaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase affects expression ISO o-Phthalaldehyde affects the expression of AICDA mRNA CTD PMID:22302311 NCBI chr 4:155,359,909...155,371,104
Ensembl chr 4:155,359,921...155,369,671
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 affects expression ISO o-Phthalaldehyde affects the expression of AKR1C18 mRNA CTD PMID:22302311 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Ccl6 chemokine (C-C motif) ligand 6 affects expression ISO o-Phthalaldehyde affects the expression of CCL6 mRNA CTD PMID:22302311 NCBI chr10:70,798,118...70,802,750
Ensembl chr10:70,797,124...70,802,782
JBrowse link
G Ccna2 cyclin A2 affects expression ISO o-Phthalaldehyde affects the expression of CCNA2 mRNA CTD PMID:22302311 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 affects expression ISO o-Phthalaldehyde affects the expression of CCNB1 mRNA CTD PMID:22302311 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccne2 cyclin E2 affects expression ISO o-Phthalaldehyde affects the expression of CCNE2 mRNA CTD PMID:22302311 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Ccr4 C-C motif chemokine receptor 4 affects expression ISO o-Phthalaldehyde affects the expression of CCR4 mRNA CTD PMID:22302311 NCBI chr 8:122,530,152...122,535,959
Ensembl chr 8:122,530,624...122,532,070
JBrowse link
G Cd207 CD207 molecule affects expression ISO o-Phthalaldehyde affects the expression of CD207 mRNA CTD PMID:22302311 NCBI chr 4:115,333,124...115,355,034
Ensembl chr 4:115,348,491...115,354,795
JBrowse link
G Cd5l Cd5 molecule-like affects expression ISO o-Phthalaldehyde affects the expression of CD5L mRNA CTD PMID:22302311 NCBI chr 2:186,685,104...186,696,117
Ensembl chr 2:186,685,104...186,696,117
JBrowse link
G Cd83 CD83 molecule affects expression ISO o-Phthalaldehyde affects the expression of CD83 mRNA CTD PMID:22302311 NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790
JBrowse link
G Cdc20 cell division cycle 20 affects expression ISO o-Phthalaldehyde affects the expression of CDC20 mRNA CTD PMID:22302311 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Cdc25c cell division cycle 25C affects expression ISO o-Phthalaldehyde affects the expression of CDC25C mRNA CTD PMID:22302311 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects expression ISO o-Phthalaldehyde affects the expression of CDK1 mRNA CTD PMID:22302311 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Clec7a C-type lectin domain containing 7A affects expression ISO o-Phthalaldehyde affects the expression of CLEC7A mRNA CTD PMID:22302311 NCBI chr 4:163,216,152...163,227,367
Ensembl chr 4:163,216,163...163,227,334
JBrowse link
G Col8a1 collagen type VIII alpha 1 chain affects expression ISO o-Phthalaldehyde affects the expression of COL8A1 mRNA CTD PMID:22302311 NCBI chr11:44,877,690...45,006,203
Ensembl chr11:44,877,859...45,007,891
JBrowse link
G Cphx1 cytoplasmic polyadenylated homeobox 1 affects expression ISO o-Phthalaldehyde affects the expression of CPHX1 mRNA CTD PMID:22302311 NCBI chr16:3,787,141...3,796,715
Ensembl chr16:3,786,686...3,796,047
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 affects expression ISO o-Phthalaldehyde affects the expression of CTLA4 mRNA CTD PMID:22302311 NCBI chr 9:67,699,397...67,706,068
Ensembl chr 9:67,699,379...67,706,065
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO o-Phthalaldehyde results in decreased expression of CYP1A1 mRNA CTD PMID:20112102 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression ISO o-Phthalaldehyde results in decreased expression of CYP2E1 mRNA CTD PMID:20112102 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO o-Phthalaldehyde results in decreased activity of DIO1 protein CTD PMID:30561685 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO o-Phthalaldehyde results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO o-Phthalaldehyde results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO o-Phthalaldehyde affects the expression of E2F1 mRNA CTD PMID:22302311 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Fabp7 fatty acid binding protein 7 affects expression ISO o-Phthalaldehyde affects the expression of FABP7 mRNA CTD PMID:22302311 NCBI chr20:40,769,624...40,773,156
Ensembl chr20:40,769,586...40,773,349
JBrowse link
G Fxyd4 FXYD domain-containing ion transport regulator 4 affects expression ISO o-Phthalaldehyde affects the expression of FXYD4 mRNA CTD PMID:22302311 NCBI chr 4:149,984,206...149,988,744
Ensembl chr 4:149,984,206...149,988,295
JBrowse link
G Gzmb granzyme B affects expression ISO o-Phthalaldehyde affects the expression of GZMB mRNA CTD PMID:22302311 NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316
JBrowse link
G Ifng interferon gamma increases expression ISO o-Phthalaldehyde results in increased expression of IFNG mRNA CTD PMID:21785612 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 increases expression ISO o-Phthalaldehyde results in increased expression of IL10 mRNA CTD PMID:21785612 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B affects expression ISO o-Phthalaldehyde affects the expression of IL12B mRNA CTD PMID:22302311 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il13 interleukin 13 increases expression ISO o-Phthalaldehyde results in increased expression of IL13 mRNA CTD PMID:21785612 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il1b interleukin 1 beta increases expression ISO o-Phthalaldehyde results in increased expression of IL1B mRNA CTD PMID:21785612 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il21 interleukin 21 affects expression ISO o-Phthalaldehyde affects the expression of IL21 mRNA CTD PMID:22302311 NCBI chr 2:123,965,021...123,972,356
Ensembl chr 2:123,965,021...123,972,356
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha affects expression ISO o-Phthalaldehyde affects the expression of IL2RA mRNA CTD PMID:22302311 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il4 interleukin 4 affects expression
increases expression
ISO o-Phthalaldehyde affects the expression of IL4 mRNA
o-Phthalaldehyde results in increased expression of IL4 mRNA; o-Phthalaldehyde results in increased expression of IL4 protein
CTD PMID:19110043, PMID:20176622, PMID:21785612, PMID:22302311 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 increases expression ISO o-Phthalaldehyde results in increased expression of IL5 mRNA CTD PMID:19110043, PMID:21785612 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Itgav integrin subunit alpha V affects expression ISO o-Phthalaldehyde affects the expression of ITGAV mRNA CTD PMID:22302311 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Lgals7 galectin 7 affects expression ISO o-Phthalaldehyde affects the expression of LGALS7 mRNA CTD PMID:22302311 NCBI chr 1:87,044,823...87,047,223
Ensembl chr 1:87,045,335...87,047,223
JBrowse link
G Mki67 marker of proliferation Ki-67 affects expression ISO o-Phthalaldehyde affects the expression of MKI67 mRNA CTD PMID:22302311 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Nts neurotensin affects expression ISO o-Phthalaldehyde affects the expression of NTS mRNA CTD PMID:22302311 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
JBrowse link
G Thbs1 thrombospondin 1 affects expression ISO o-Phthalaldehyde affects the expression of THBS1 mRNA CTD PMID:22302311 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Thbs4 thrombospondin 4 affects expression ISO o-Phthalaldehyde affects the expression of THBS4 mRNA CTD PMID:22302311 NCBI chr 2:22,343,727...22,385,855
Ensembl chr 2:22,343,727...22,385,855
JBrowse link
G Timd2 T-cell immunoglobulin and mucin domain containing 2 affects expression ISO o-Phthalaldehyde affects the expression of TIMD2 mRNA CTD PMID:22302311 NCBI chr10:31,755,473...31,796,423
Ensembl chr10:31,755,510...31,790,263
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 affects expression ISO o-Phthalaldehyde affects the expression of TIMP1 mRNA CTD PMID:22302311 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor increases expression ISO o-Phthalaldehyde results in increased expression of TNF mRNA CTD PMID:21785612 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpm6 transient receptor potential cation channel, subfamily M, member 6 affects expression ISO o-Phthalaldehyde affects the expression of TRPM6 mRNA CTD PMID:22302311 NCBI chr 1:234,478,908...234,631,264
Ensembl chr 1:234,479,289...234,596,971
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        solvent 16459
          formic acid 7881
            formyl group 7847
              aldehyde 7847
                dialdehyde 117
                  (6E)-8-oxogeranial 0
                  2,5-diformylfuran 0
                  2,6,10-trimethyldodeca-2,4,6,8,10-pentaenedial 0
                  2,6-dimethyldeca-2,4,6,8-tetraenedial 0
                  2,6-dimethylocta-2,4,6-trienedial 0
                  4,4'-diapolycopenedial 0
                  4,9-dimethyldodeca-2,4,6,8,10-pentaenedial 0
                  4-methyl-1,4-dihydropyridine-3,5-dicarbaldehyde 0
                  4-methylocta-2,4,6-trienedial 0
                  aflatoxin B1 dialdehyde 0
                  aflatoxin B1 dialdehyde(1-) 0
                  bixin dialdehyde 0
                  botrydial 0
                  but-2-enedial + 3
                  crocetin dialdehyde 0
                  dolichodial 0
                  glutaraldehyde 12
                  glyoxal + 22
                  iridodial + 0
                  malonaldehyde 50
                  oleocanthal 0
                  oleuropein (dialdehyde form) 0
                  phthalaldehyde 45
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            formyl group 7847
                                              aldehyde 7847
                                                dialdehyde 117
                                                  (6E)-8-oxogeranial 0
                                                  2,5-diformylfuran 0
                                                  2,6,10-trimethyldodeca-2,4,6,8,10-pentaenedial 0
                                                  2,6-dimethyldeca-2,4,6,8-tetraenedial 0
                                                  2,6-dimethylocta-2,4,6-trienedial 0
                                                  4,4'-diapolycopenedial 0
                                                  4,9-dimethyldodeca-2,4,6,8,10-pentaenedial 0
                                                  4-methyl-1,4-dihydropyridine-3,5-dicarbaldehyde 0
                                                  4-methylocta-2,4,6-trienedial 0
                                                  aflatoxin B1 dialdehyde 0
                                                  aflatoxin B1 dialdehyde(1-) 0
                                                  bixin dialdehyde 0
                                                  botrydial 0
                                                  but-2-enedial + 3
                                                  crocetin dialdehyde 0
                                                  dolichodial 0
                                                  glutaraldehyde 12
                                                  glyoxal + 22
                                                  iridodial + 0
                                                  malonaldehyde 50
                                                  oleocanthal 0
                                                  oleuropein (dialdehyde form) 0
                                                  phthalaldehyde 45
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.