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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gitoxigenin
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Accession:CHEBI:38105 term browser browse the term
Definition:A 16beta-hydroxy steroid that has formula C23H34O5.
Synonyms:exact_synonym: 3beta,14,16beta-trihydroxy-5beta-card-20(22)-enolide
 related_synonym: 16beta-Hydroxydigitoxigenin;   Formula=C23H34O5;   InChI=1S/C23H34O5/c1-21-7-5-15(24)10-14(21)3-4-17-16(21)6-8-22(2)20(13-9-19(26)28-12-13)18(25)11-23(17,22)27/h9,14-18,20,24-25,27H,3-8,10-12H2,1-2H3/t14-,15+,16+,17-,18+,20+,21+,22-,23+/m1/s1;   InChIKey=PVAMXWLZJKTXFW-VQMOFDJESA-N;   SMILES=[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@]([H])([C@@H](O)C[C@]34O)C3=CC(=O)OC3)[C@@]1(C)CC[C@H](O)C2
 xref: Beilstein:96483;   CAS:545-26-6


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oleandrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 decreases activity EXP oleandrin results in decreased activity of ATP1A1 protein CTD PMID:28438630 NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,508...104,384,547 		JBrowse link
G CASP3 caspase 3 decreases cleavage EXP oleandrin results in decreased cleavage of CASP3 protein CTD PMID:28438630 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5052
    chemical entity 5080
      molecular entity 5051
        polyatomic entity 5032
          heteroatomic molecular entity 5001
            hydroxides 4835
              organic hydroxy compound 4767
                hydroxy steroid 75
                  16-hydroxy steroid 2
                    16beta-hydroxy steroid 2
                      gitoxigenin 2
                        (1R,5R,6S,11S,12R,14R)-22-[(1S)-1-Hydroxyethyl]-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-diene-9,12-diol 0
                        Abikoviromycin 0
                        Awajanomycin 0
                        Batrachotoxinin A 0
                        Kobutimycin A 0
                        Kobutimycin B 0
                        LSM-1903 0
                        Latumcidin 0
                        Nocarditriene 0
                        digitalin 0
                        gitoxigenin 3-acetate 0
                        gitoxin + 0
                        oleandrigenin + 2
                        strospeside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 5052
    subatomic particle 5043
      composite particle 5043
        hadron 5071
          baryon 5043
            nucleon 5043
              atomic nucleus 5043
                atom 5043
                  main group element atom 5013
                    p-block element atom 5010
                      carbon group element atom 4927
                        carbon atom 4954
                          organic molecular entity 4926
                            heteroorganic entity 4768
                              organochalcogen compound 4730
                                organooxygen compound 4692
                                  ester 533
                                    carboxylic ester 496
                                      lactone 373
                                        steroid lactone 2
                                          cardanolide 2
                                            5beta-cardanolide 2
                                              gitoxigenin 2
                                                (1R,5R,6S,11S,12R,14R)-22-[(1S)-1-Hydroxyethyl]-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-diene-9,12-diol 0
                                                Abikoviromycin 0
                                                Awajanomycin 0
                                                Batrachotoxinin A 0
                                                Kobutimycin A 0
                                                Kobutimycin B 0
                                                LSM-1903 0
                                                Latumcidin 0
                                                Nocarditriene 0
                                                digitalin 0
                                                gitoxigenin 3-acetate 0
                                                gitoxin + 0
                                                oleandrigenin + 2
                                                strospeside 0
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