CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: gitoxigenin
Accession: CHEBI:38105
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Definition: A 16beta-hydroxy steroid that has formula C23H34O5.
Synonyms: exact_synonym: 3beta,14,16beta-trihydroxy-5beta-card-20(22)-enolide
related_synonym: 16beta-Hydroxydigitoxigenin; Formula=C23H34O5; InChI=1S/C23H34O5/c1-21-7-5-15(24)10-14(21)3-4-17-16(21)6-8-22(2)20(13-9-19(26)28-12-13)18(25)11-23(17,22)27/h9,14-18,20,24-25,27H,3-8,10-12H2,1-2H3/t14-,15+,16+,17-,18+,20+,21+,22-,23+/m1/s1; InChIKey=PVAMXWLZJKTXFW-VQMOFDJESA-N; SMILES=[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@]([H])([C@@H](O)C[C@]34O)C3=CC(=O)OC3)[C@@]1(C)CC[C@H](O)C2
xref: Beilstein:96483; CAS:545-26-6
G
Casp3
caspase 3
increases activity
ISO
oleandrin results in increased activity of CASP3 protein
CTD
PMID:24172227
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Casp8
caspase 8
increases activity
ISO
oleandrin results in increased activity of CASP8 protein
CTD
PMID:24172227
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
G
Cxcr1
C-X-C motif chemokine receptor 1
increases expression
ISO
oleandrin results in increased expression of CXCR1 mRNA; oleandrin results in increased expression of CXCR1 protein
CTD
PMID:24172227
NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274
G
Cxcr2
C-X-C motif chemokine receptor 2
increases expression
ISO
oleandrin results in increased expression of CXCR2 mRNA; oleandrin results in increased expression of CXCR2 protein
CTD
PMID:24172227
NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
G
Cxcr4
C-X-C motif chemokine receptor 4
increases expression
ISO
oleandrin results in increased expression of CXCR4 mRNA
CTD
PMID:24172227
NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
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