CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: gitoxigenin
Accession: CHEBI:38105
browse the term
Definition: A 16beta-hydroxy steroid that has formula C23H34O5.
Synonyms: exact_synonym: 3beta,14,16beta-trihydroxy-5beta-card-20(22)-enolide
related_synonym: 16beta-Hydroxydigitoxigenin; Formula=C23H34O5; InChI=1S/C23H34O5/c1-21-7-5-15(24)10-14(21)3-4-17-16(21)6-8-22(2)20(13-9-19(26)28-12-13)18(25)11-23(17,22)27/h9,14-18,20,24-25,27H,3-8,10-12H2,1-2H3/t14-,15+,16+,17-,18+,20+,21+,22-,23+/m1/s1; InChIKey=PVAMXWLZJKTXFW-VQMOFDJESA-N; SMILES=[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@]([H])([C@@H](O)C[C@]34O)C3=CC(=O)OC3)[C@@]1(C)CC[C@H](O)C2
xref: Beilstein:96483; CAS:545-26-6
G
Casp3
caspase 3
increases activity
ISO
oleandrin results in increased activity of CASP3 protein
CTD
PMID:24172227
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp8
caspase 8
increases activity
ISO
oleandrin results in increased activity of CASP8 protein
CTD
PMID:24172227
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
G
Cxcr1
C-X-C motif chemokine receptor 1
increases expression
ISO
oleandrin results in increased expression of CXCR1 mRNA; oleandrin results in increased expression of CXCR1 protein
CTD
PMID:24172227
NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084
G
Cxcr2
C-X-C motif chemokine receptor 2
increases expression
ISO
oleandrin results in increased expression of CXCR2 mRNA; oleandrin results in increased expression of CXCR2 protein
CTD
PMID:24172227
NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
G
Cxcr4
C-X-C motif chemokine receptor 4
increases expression
ISO
oleandrin results in increased expression of CXCR4 mRNA
CTD
PMID:24172227
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19811
chemical entity
19840
molecular entity
19809
polyatomic entity
19767
heteroatomic molecular entity
19723
hydroxides
19300
organic hydroxy compound
18928
hydroxy steroid
14419
16-hydroxy steroid
158
16beta-hydroxy steroid
9
gitoxigenin
5
(1R,5R,6S,11S,12R,14R)-22-[(1S)-1-Hydroxyethyl]-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-diene-9,12-diol
0
Abikoviromycin
0
Awajanomycin
0
Batrachotoxinin A
0
Kobutimycin A
0
Kobutimycin B
0
LSM-1903
0
Latumcidin
0
Nocarditriene
0
digitalin
0
gitoxigenin 3-acetate
0
gitoxin +
0
oleandrigenin +
5
strospeside
0
Path 2
CHEBI ontology
19811
subatomic particle
19809
composite particle
19809
hadron
19840
baryon
19809
nucleon
19809
atomic nucleus
19809
atom
19809
main group element atom
19759
p-block element atom
19759
carbon group element atom
19708
carbon atom
19734
organic molecular entity
19705
heteroorganic entity
19459
organochalcogen compound
19222
organooxygen compound
19137
ester
17247
carboxylic ester
16563
lactone
12512
steroid lactone
465
cardanolide
49
5beta-cardanolide
49
gitoxigenin
5
(1R,5R,6S,11S,12R,14R)-22-[(1S)-1-Hydroxyethyl]-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-diene-9,12-diol
0
Abikoviromycin
0
Awajanomycin
0
Batrachotoxinin A
0
Kobutimycin A
0
Kobutimycin B
0
LSM-1903
0
Latumcidin
0
Nocarditriene
0
digitalin
0
gitoxigenin 3-acetate
0
gitoxin +
0
oleandrigenin +
5
strospeside
0