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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gitoxigenin
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Accession:CHEBI:38105 term browser browse the term
Definition:A 16beta-hydroxy steroid that has formula C23H34O5.
Synonyms:exact_synonym: 3beta,14,16beta-trihydroxy-5beta-card-20(22)-enolide
 related_synonym: 16beta-Hydroxydigitoxigenin;   Formula=C23H34O5;   InChI=1S/C23H34O5/c1-21-7-5-15(24)10-14(21)3-4-17-16(21)6-8-22(2)20(13-9-19(26)28-12-13)18(25)11-23(17,22)27/h9,14-18,20,24-25,27H,3-8,10-12H2,1-2H3/t14-,15+,16+,17-,18+,20+,21+,22-,23+/m1/s1;   InChIKey=PVAMXWLZJKTXFW-VQMOFDJESA-N;   SMILES=[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@]([H])([C@@H](O)C[C@]34O)C3=CC(=O)OC3)[C@@]1(C)CC[C@H](O)C2
 xref: Beilstein:96483;   CAS:545-26-6

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oleandrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO oleandrin results in increased activity of CASP3 protein CTD PMID:24172227 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 increases activity ISO oleandrin results in increased activity of CASP8 protein CTD PMID:24172227 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases expression ISO oleandrin results in increased expression of CXCR1 mRNA; oleandrin results in increased expression of CXCR1 protein CTD PMID:24172227 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 increases expression ISO oleandrin results in increased expression of CXCR2 mRNA; oleandrin results in increased expression of CXCR2 protein CTD PMID:24172227 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO oleandrin results in increased expression of CXCR4 mRNA CTD PMID:24172227 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19841
      molecular entity 19839
        polyatomic entity 19754
          heteroatomic molecular entity 19681
            hydroxides 19113
              organic hydroxy compound 18674
                hydroxy steroid 12393
                  16-hydroxy steroid 162
                    16beta-hydroxy steroid 9
                      gitoxigenin 5
                        LSM-1903 0
                        digitalin 0
                        gitoxigenin 3-acetate 0
                        gitoxin + 0
                        oleandrigenin + 5
                        strospeside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic ester 14370
                                        lactone 5993
                                          steroid lactone 405
                                            cardanolide 41
                                              5beta-cardanolide 41
                                                gitoxigenin 5
                                                  LSM-1903 0
                                                  digitalin 0
                                                  gitoxigenin 3-acetate 0
                                                  gitoxin + 0
                                                  oleandrigenin + 5
                                                  strospeside 0
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