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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:thiadiazoles
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Accession:CHEBI:38099 term browser browse the term
Synonyms:xref_mesh: MESH:D013830

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thiadiazoles term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipa lipase A, lysosomal acid type multiple interactions ISO Thiadiazoles analog results in increased carbamoylation of and results in decreased activity of LIPA protein CTD PMID:20557099 NCBI chr 1:252,816,536...252,959,348
Ensembl chr 1:252,816,527...252,849,904 		JBrowse link
(S)-timolol (anhydrous) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO Timolol binds to and results in decreased activity of ADRB1 protein; Timolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP] CTD PMID:11436944 PMID:15060759 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO [Timolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; Timolol binds to and results in decreased activity of ADRB2 protein CTD PMID:11436944 PMID:17925438 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834 		JBrowse link
G Aoc1 amine oxidase, copper containing 1 multiple interactions EXP Timolol inhibits the reaction [Epinephrine results in increased activity of AOC1 protein] CTD PMID:2860926 NCBI chr 4:78,496,043...78,515,582
Ensembl chr 4:78,496,043...78,515,584 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects response to substance ISO CYP2D6 gene SNP affects the susceptibility to Timolol CTD PMID:19284319 PMID:20925579 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP		 [Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; [Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased phosphorylation of MAPK1 protein]; Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Gadolinium inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; W 7 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]		 CTD PMID:11914123 PMID:18977218 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP		 [Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; [Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased phosphorylation of MAPK3 protein]; Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Gadolinium inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; W 7 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]		 CTD PMID:11914123 PMID:18977218 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Rgs3 regulator of G-protein signaling 3 multiple interactions ISO RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18977218 NCBI chr 5:78,429,017...78,567,281
Ensembl chr 5:78,428,669...78,567,288 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 multiple interactions ISO RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18977218 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108 		JBrowse link
acetazolamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Acetazolamide results in increased expression of ABCA1 mRNA CTD PMID:19274763 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Akap17a A-kinase anchoring protein 17A increases expression ISO Acetazolamide results in increased expression of AKAP17B mRNA CTD PMID:19274763 NCBI chr12:18,527,116...18,531,780
Ensembl chr12:18,526,422...18,531,161 		JBrowse link
G Akap9 A-kinase anchoring protein 9 increases expression ISO Acetazolamide results in increased expression of AKAP9 mRNA CTD PMID:19274763 NCBI chr 4:27,195,346...27,331,582
Ensembl chr 4:27,195,346...27,331,582 		JBrowse link
G Ammecr1l AMMECR1 like increases expression ISO Acetazolamide results in increased expression of AMMECR1L mRNA CTD PMID:19274763 NCBI chr18:24,539,530...24,563,576
Ensembl chr18:24,540,659...24,563,576 		JBrowse link
G Anp32a acidic nuclear phosphoprotein 32 family member A increases expression ISO Acetazolamide results in increased expression of ANP32A mRNA CTD PMID:19274763 NCBI chr 8:67,295,578...67,333,075
Ensembl chr 8:67,295,727...67,333,247 		JBrowse link
G Aqp1 aquaporin 1 decreases expression ISO Acetazolamide results in decreased expression of AQP1 protein CTD PMID:17219999 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360 		JBrowse link
G Arhgap45 Rho GTPase activating protein 45 affects expression ISO Acetazolamide affects the expression of ARHGAP45 mRNA CTD PMID:25811541 NCBI chr 7:12,541,032...12,741,314
Ensembl chr 7:12,541,061...12,741,296 		JBrowse link
G Arid2 AT-rich interaction domain 2 increases expression ISO Acetazolamide results in increased expression of ARID2 mRNA CTD PMID:19274763 NCBI chr 7:137,680,564...137,798,329
Ensembl chr 7:137,680,530...137,795,655 		JBrowse link
G Brd4 bromodomain containing 4 increases expression ISO Acetazolamide results in increased expression of BRD4 mRNA CTD PMID:19274763 NCBI chr 7:14,222,101...14,303,055
Ensembl chr 7:14,222,101...14,303,055 		JBrowse link
G Ca12 carbonic anhydrase 12 decreases activity
multiple interactions		 ISO Acetazolamide results in decreased activity of CA12 protein
Acetazolamide binds to and results in decreased activity of CA12 protein		 CTD PMID:21851094 PMID:28251759 NCBI chr 8:72,405,770...72,461,425
Ensembl chr 8:72,405,748...72,460,240 		JBrowse link
G Ca13 carbonic anhydrase 13 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA13 protein CTD PMID:28251759 NCBI chr 2:88,282,961...88,314,254
Ensembl chr 2:88,282,961...88,314,254 		JBrowse link
G Ca14 carbonic anhydrase 14 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA14 protein CTD PMID:28251759 NCBI chr 2:198,010,142...198,017,635
Ensembl chr 2:198,010,349...198,016,898 		JBrowse link
G Ca3 carbonic anhydrase 3 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410 		JBrowse link
G Ca4 carbonic anhydrase 4 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA4 protein CTD PMID:28251759 NCBI chr10:72,272,286...72,281,069
Ensembl chr10:72,272,248...72,281,067 		JBrowse link
G Ca5a carbonic anhydrase 5A multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA5A protein CTD PMID:28251759 NCBI chr19:54,731,829...54,761,697
Ensembl chr19:54,731,859...54,761,670 		JBrowse link
G Ca5b carbonic anhydrase 5B multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA5B protein CTD PMID:28251759 NCBI chr  X:32,232,106...32,291,124
Ensembl chr  X:32,232,142...32,292,072 		JBrowse link
G Ca6 carbonic anhydrase 6 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA6 protein CTD PMID:28251759 NCBI chr 5:167,226,246...167,244,786
Ensembl chr 5:167,226,246...167,244,786 		JBrowse link
G Ca9 carbonic anhydrase 9 decreases activity
multiple interactions		 ISO Acetazolamide results in decreased activity of CA9 protein
Acetazolamide binds to and results in decreased activity of CA9 protein		 CTD PMID:21851094 PMID:28251759 NCBI chr 5:59,008,277...59,015,535
Ensembl chr 5:59,008,933...59,015,528 		JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions
decreases activity		 ISO Acetazolamide binds to and results in decreased activity of CA1 protein; Indomethacin inhibits the reaction [Acetazolamide results in decreased activity of CA1 protein] CTD PMID:11430635 PMID:17826101 PMID:19231207 PMID:28117934 PMID:28251759 PMID:29131470 PMID:29283199 PMID:29457667 PMID:29975450 PMID:29992664 PMID:30291660 PMID:30368973 PMID:30431690 PMID:30537031 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions
decreases activity		 ISO Acetazolamide binds to and results in decreased activity of CA2 protein; Indomethacin inhibits the reaction [Acetazolamide results in decreased activity of CA2 protein] CTD PMID:11430635 PMID:16858005 PMID:17826101 PMID:19231207 PMID:21851094 PMID:28117934 PMID:28251759 PMID:29131470 PMID:29283199 PMID:29457667 PMID:29975450 PMID:29992664 PMID:30291660 PMID:30368973 PMID:30431690 PMID:30537031 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029 		JBrowse link
G Car7 carbonic anhydrase 7 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA7 protein CTD PMID:28251759 NCBI chr19:636,545...645,935
Ensembl chr19:636,545...645,937 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Acetazolamide promotes the reaction [bleomycetin results in increased activity of CASP3 protein] CTD PMID:21040473 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cbx3 chromobox 3 increases expression ISO Acetazolamide results in increased expression of CBX3 mRNA CTD PMID:19274763 NCBI chr 4:81,243,809...81,257,898
Ensembl chr 4:81,244,469...81,257,897 		JBrowse link
G Ccnd2 cyclin D2 increases expression ISO Acetazolamide results in increased expression of CCND2 mRNA CTD PMID:19274763 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207 		JBrowse link
G Cd47 Cd47 molecule increases expression ISO Acetazolamide results in increased expression of CD47 mRNA CTD PMID:19274763 NCBI chr11:53,511,485...53,575,754
Ensembl chr11:53,514,595...53,575,175 		JBrowse link
G Cirbp cold inducible RNA binding protein increases expression ISO Acetazolamide results in increased expression of CIRBP mRNA CTD PMID:19274763 NCBI chr 7:12,400,066...12,405,054
Ensembl chr 7:12,401,207...12,405,022 		JBrowse link
G Clcn3 chloride voltage-gated channel 3 increases expression ISO Acetazolamide results in increased expression of CLCN3 mRNA CTD PMID:19274763 NCBI chr16:32,448,821...32,520,649
Ensembl chr16:32,449,116...32,519,148 		JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked increases expression ISO Acetazolamide results in increased expression of DDX3X mRNA CTD PMID:19274763 NCBI chr  X:10,400,363...10,414,010
Ensembl chr  X:10,400,366...10,413,995 		JBrowse link
G Ddx6 DEAD-box helicase 6 increases expression ISO Acetazolamide results in increased expression of DDX6 mRNA CTD PMID:19274763 NCBI chr 8:48,924,768...48,961,394
Ensembl chr 8:48,925,604...48,958,026 		JBrowse link
G Dsc2 desmocollin 2 increases expression ISO Acetazolamide results in increased expression of DSC2 mRNA CTD PMID:19274763 NCBI chr18:11,826,705...11,858,801
Ensembl chr18:11,826,706...11,858,754 		JBrowse link
G Glg1 golgi glycoprotein 1 increases expression ISO Acetazolamide results in increased expression of GLG1 mRNA CTD PMID:19274763 NCBI chr19:42,983,879...43,088,074
Ensembl chr19:42,983,869...43,090,841 		JBrowse link
G Glul glutamate-ammonia ligase increases expression ISO Acetazolamide results in increased expression of GLUL mRNA CTD PMID:19274763 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229 		JBrowse link
G Htra1 HtrA serine peptidase 1 increases expression ISO Acetazolamide results in increased expression of HTRA1 mRNA CTD PMID:19274763 NCBI chr 1:201,499,067...201,548,508
Ensembl chr 1:201,499,028...201,548,513 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor increases expression ISO Acetazolamide results in increased expression of IGF1R mRNA CTD PMID:19274763 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516 		JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 increases expression ISO Acetazolamide results in increased expression of ITPR2 mRNA CTD PMID:19274763 NCBI chr 4:180,423,452...180,800,088
Ensembl chr 4:180,538,389...180,722,358 		JBrowse link
G LOC102546572 zinc finger protein 709-like increases expression ISO Acetazolamide results in increased expression of ZFP617 mRNA CTD PMID:19274763 NCBI chr 7:15,015,985...15,038,622 JBrowse link
G Mab21l2 mab-21 like 2 decreases expression ISO Acetazolamide results in decreased expression of MAB21L2 mRNA CTD PMID:19274763 NCBI chr 2:185,849,749...185,852,833
Ensembl chr 2:185,850,232...185,852,759 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression ISO Acetazolamide results in increased expression of MAP3K1 mRNA CTD PMID:19274763 NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207 		JBrowse link
G Mt1 metallothionein 1 decreases expression ISO Acetazolamide results in decreased expression of MT1 mRNA CTD PMID:19274763 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Naa15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit increases expression ISO Acetazolamide results in increased expression of NAA15 mRNA CTD PMID:19274763 NCBI chr 2:140,471,437...140,534,259
Ensembl chr 2:140,471,690...140,534,259 		JBrowse link
G Ndrg1 N-myc downstream regulated 1 increases expression ISO Acetazolamide results in increased expression of NDRG1 mRNA CTD PMID:19274763 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714 		JBrowse link
G Nrip1 nuclear receptor interacting protein 1 increases expression ISO Acetazolamide results in increased expression of NRIP1 mRNA CTD PMID:19274763 NCBI chr11:14,658,225...14,742,478
Ensembl chr11:14,658,225...14,741,563 		JBrowse link
G Peg3 paternally expressed 3 increases expression ISO Acetazolamide results in increased expression of PEG3 mRNA CTD PMID:19274763 NCBI chr 1:70,210,810...70,237,450
Ensembl chr 1:70,222,964...70,237,443 		JBrowse link
G Pou2f1 POU class 2 homeobox 1 increases expression ISO Acetazolamide results in increased expression of POU2F1 mRNA CTD PMID:19274763 NCBI chr13:84,075,316...84,217,368
Ensembl chr13:84,083,632...84,217,366 		JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B increases expression ISO Acetazolamide results in increased expression of PPM1B mRNA CTD PMID:19274763 NCBI chr 6:8,219,385...8,280,127
Ensembl chr 6:8,218,696...8,280,124 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha increases expression ISO Acetazolamide results in increased expression of PPP3CA mRNA CTD PMID:19274763 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854 		JBrowse link
G Rbm39 RNA binding motif protein 39 increases expression ISO Acetazolamide results in increased expression of RBM39 mRNA CTD PMID:19274763 NCBI chr 3:151,691,498...151,724,723
Ensembl chr 3:151,691,514...151,724,654
Ensembl chr 3:151,691,514...151,724,654 		JBrowse link
G Rbmx RNA binding motif protein, X-linked increases expression ISO Acetazolamide results in increased expression of RBMX mRNA CTD PMID:19274763 NCBI chr  X:159,881,835...159,891,405
Ensembl chr  X:159,884,885...159,891,326 		JBrowse link
G Satb1 SATB homeobox 1 increases expression ISO Acetazolamide results in increased expression of SATB1 mRNA CTD PMID:19274763 NCBI chr 9:2,181,135...2,277,949
Ensembl chr 9:2,190,915...2,274,629 		JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO Acetazolamide results in increased expression of SC5D mRNA CTD PMID:19274763 NCBI chr 8:46,525,406...46,537,014
Ensembl chr 8:46,525,400...46,537,050 		JBrowse link
G Schip1 schwannomin interacting protein 1 increases expression ISO Acetazolamide results in increased expression of SCHIP1 mRNA CTD PMID:19274763 NCBI chr 2:172,312,290...173,087,236
Ensembl chr 2:172,312,298...172,459,165 		JBrowse link
G Sdc4 syndecan 4 increases expression ISO Acetazolamide results in increased expression of SDC4 mRNA CTD PMID:19274763 NCBI chr 3:160,872,503...160,891,190
Ensembl chr 3:160,872,503...160,891,190 		JBrowse link
G Sema4b semaphorin 4B increases expression ISO Acetazolamide results in increased expression of SEMA4B mRNA CTD PMID:19274763 NCBI chr 1:141,986,145...142,014,400
Ensembl chr 1:141,986,145...142,014,398 		JBrowse link
G Sf3b1 splicing factor 3b, subunit 1 increases expression ISO Acetazolamide results in increased expression of SF3B1 mRNA CTD PMID:19274763 NCBI chr 9:61,594,620...61,634,510
Ensembl chr 9:61,594,620...61,634,510 		JBrowse link
G Sfmbt2 Scm-like with four mbt domains 2 increases expression ISO Acetazolamide results in increased expression of SFMBT2 mRNA CTD PMID:19274763 NCBI chr17:71,719,012...71,904,303
Ensembl chr17:71,723,620...71,897,972 		JBrowse link
G Shox2 short stature homeobox 2 increases expression ISO Acetazolamide results in increased expression of SHOX2 mRNA CTD PMID:19274763 NCBI chr 2:164,118,175...164,126,783
Ensembl chr 2:164,118,191...164,126,783 		JBrowse link
G Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 increases expression ISO Acetazolamide results in increased expression of SMARCC1 mRNA CTD PMID:19274763 NCBI chr 8:118,206,678...118,326,264
Ensembl chr 8:118,206,698...118,325,537 		JBrowse link
G Stx3 syntaxin 3 increases expression ISO Acetazolamide results in increased expression of STX3 mRNA CTD PMID:19274763 NCBI chr 1:228,137,781...228,195,004
Ensembl chr 1:228,149,867...228,194,977 		JBrowse link
G Styx serine/threonine/tyrosine interacting protein increases expression ISO Acetazolamide results in increased expression of STYX mRNA CTD PMID:19274763 NCBI chr15:19,690,079...19,720,683
Ensembl chr15:19,690,194...19,717,774 		JBrowse link
G Tia1 TIA1 cytotoxic granule-associated RNA binding protein increases expression ISO Acetazolamide results in increased expression of TIA1 mRNA CTD PMID:19274763 NCBI chr 4:118,207,845...118,238,246
Ensembl chr 4:118,207,862...118,235,218 		JBrowse link
G Tmem30b transmembrane protein 30B increases expression ISO Acetazolamide results in increased expression of TMEM30B mRNA CTD PMID:19274763 NCBI chr 6:96,439,607...96,442,682
Ensembl chr 6:96,439,607...96,442,682 		JBrowse link
G Trim25 tripartite motif-containing 25 increases expression ISO Acetazolamide results in increased expression of TRIM25 mRNA CTD PMID:19274763 NCBI chr10:76,343,847...76,362,159
Ensembl chr10:76,343,847...76,362,145 		JBrowse link
G Umod uromodulin increases expression ISO Acetazolamide results in increased expression of UMOD protein CTD PMID:2655449 NCBI chr 1:189,186,027...189,199,939
Ensembl chr 1:189,186,026...189,199,376 		JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 increases expression ISO Acetazolamide results in increased expression of WNK1 mRNA CTD PMID:19274763 NCBI chr 4:152,452,211...152,578,469
Ensembl chr 4:152,452,848...152,578,446 		JBrowse link
G Zfp322a zinc finger protein 322a increases expression ISO Acetazolamide results in increased expression of ZFP322A mRNA CTD PMID:19274763 NCBI chr17:44,025,036...44,040,900
Ensembl chr17:44,025,267...44,039,284 		JBrowse link
cefazolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase decreases activity ISO Cefazolin results in decreased activity of DHFR protein CTD PMID:25418905 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases expression		 ISO Cefazolin results in increased expression of and results in decreased activity of GSR protein
Cefazolin results in increased expression of GSR mRNA		 CTD PMID:32196862 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G RT1-DOa RT1 class II, locus DOa affects expression ISO Cefazolin affects the expression of HLA-DOA mRNA CTD PMID:25811541 NCBI chr20:3,889,106...3,892,360
Ensembl chr20:3,889,370...3,892,449 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases uptake ISO SLC22A8 protein results in increased uptake of Cefazolin CTD PMID:16098483 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482 		JBrowse link
G Slc25a20 solute carrier family 25 member 20 multiple interactions EXP Cefazolin binds to and results in decreased activity of SLC25A20 protein; Cefazolin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine] CTD PMID:18452908 NCBI chr 8:117,455,308...117,476,762
Ensembl chr 8:117,455,262...117,476,734 		JBrowse link
flufenacet term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO FOE 5043 results in increased activity of NFE2L2 protein CTD PMID:20143881 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
affects activity		 ISO FOE 5043 results in increased activity of NR1I2 protein
FOE 5043 affects the activity of NR1I2 protein		 CTD PMID:20143881 PMID:23611293 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Tspo translocator protein affects activity EXP FOE 5043 affects the activity of TSPO protein CTD PMID:23611293 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609 		JBrowse link
Methazolamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ca3 carbonic anhydrase 3 multiple interactions ISO Methazolamide binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410 		JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions ISO Methazolamide binds to and results in decreased activity of CA1 protein CTD PMID:17826101 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity
multiple interactions		 ISO Methazolamide results in decreased activity of CA2 protein
Methazolamide binds to and results in decreased activity of CA2 protein		 CTD PMID:16858005 PMID:17826101 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029 		JBrowse link
G Clu clusterin affects expression ISO Methazolamide affects the expression of CLU protein CTD PMID:12388792 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857 		JBrowse link
G Gal galanin and GMAP prepropeptide affects expression ISO Methazolamide affects the expression of GAL protein CTD PMID:12388792 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925 		JBrowse link
G Gap43 growth associated protein 43 affects expression ISO Methazolamide affects the expression of GAP43 protein CTD PMID:12388792 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914 		JBrowse link
G Ret ret proto-oncogene affects expression ISO Methazolamide affects the expression of RET protein CTD PMID:12388792 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 affects expression ISO Methazolamide affects the expression of TIMP1 protein CTD PMID:12388792 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384 		JBrowse link
methidathion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO [enilconazole co-treated with methidathion] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [enilconazole co-treated with methidathion] results in increased activity of NR1I2 protein CTD PMID:25028461 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ca3 carbonic anhydrase 3 multiple interactions ISO Methazolamide binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410 		JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions ISO Methazolamide binds to and results in decreased activity of CA1 protein CTD PMID:17826101 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions
decreases activity		 ISO Methazolamide binds to and results in decreased activity of CA2 protein
Methazolamide results in decreased activity of CA2 protein		 CTD PMID:16858005 PMID:17826101 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029 		JBrowse link
G Clu clusterin affects expression ISO Methazolamide affects the expression of CLU protein CTD PMID:12388792 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857 		JBrowse link
G Gal galanin and GMAP prepropeptide affects expression ISO Methazolamide affects the expression of GAL protein CTD PMID:12388792 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925 		JBrowse link
G Gap43 growth associated protein 43 affects expression ISO Methazolamide affects the expression of GAP43 protein CTD PMID:12388792 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914 		JBrowse link
G Ret ret proto-oncogene affects expression ISO Methazolamide affects the expression of RET protein CTD PMID:12388792 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 affects expression ISO Methazolamide affects the expression of TIMP1 protein CTD PMID:12388792 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384 		JBrowse link
xanomeline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm1 cholinergic receptor, muscarinic 1 increases response to substance
multiple interactions		 ISO
EXP		 CHRM1 gene results in increased susceptibility to xanomeline; CHRM1 results in increased susceptibility to xanomeline
xanomeline binds to and results in increased activity of [CHRM1 protein binds to CHRM4 protein]		 CTD PMID:19111716 PMID:19996296 PMID:21211109 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 affects binding
multiple interactions
increases response to substance		 ISO
EXP		 xanomeline binds to CHRM4 protein
xanomeline binds to and results in increased activity of [CHRM1 protein binds to CHRM4 protein]
[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [xanomeline binds to CHRM4 protein]
CHRM4 gene results in increased susceptibility to xanomeline; CHRM4 results in increased susceptibility to xanomeline		 CTD PMID:16709648 PMID:19111716 PMID:19996296 PMID:21211109 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006 		JBrowse link
G Egr1 early growth response 1 increases expression EXP xanomeline results in increased expression of EGR1 mRNA CTD PMID:11313039 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP xanomeline results in increased expression of FOS mRNA CTD PMID:11313039 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    chemical entity 19761
      atom 19759
        nonmetal atom 19641
          carbon atom 19559
            organic molecular entity 19559
              heteroorganic entity 19195
                organic heterocyclic compound 18510
                  organic heteromonocyclic compound 16986
                    thiadiazoles 92
                      (2R,3R,4S,5R)-5-(3,4-dichlorophenyl)-5'-methyl-1',3'-dioxo-4-\{[4-(1,2,3-thiadiazol-4-yl)phenyl]carbamoyl\}-1',3',4,5-tetrahydro-3H-spiro[furan-2,2'-indene]-3-carboxylic acid 0
                      (R)-1-amino-1-[5-(dimethylamino)-1,3,4-thiadiazol-2-yl]methanesulfonamide 0
                      1,2,3-Thiadiazole, 5-methyl- 0
                      1-(5-amino-1,3,4-thiadiazol-2-yl)-1,1-difluoromethanesulfonamide 0
                      1-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-3-[1,1,1-trifluoro-2-(trifluoromethyl)butan-2-yl]urea 0
                      1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-3-[1,1,1-trifluoro-2-(trifluoromethyl)butan-2-yl]urea 0
                      1-butyl-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-4-hydroxy-2-oxoquinoline-3-carboxamide 0
                      2,3,4,5,6-pentafluoro-N-methyl-N(alpha)-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)carbamoyl]-L-phenylalaninamide 0
                      2-(acetylamino)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-3-ium 0
                      2-amino-5-ethyl-1,3,4-thiadiazole 0
                      3-(4-methyl-1,2,3-thiadiazolyl)-6-trichloromethyl[1,2,4]triazolo[3,4-b][1,3,4]thiadizole 0
                      5-(2-phenylethyl)-1,3,4-thiadiazol-2-amine 0
                      5-\{[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino\}-1,3,4-thiadiazole-2-sulfonamide 0
                      5-amino-1,3,4-thiadiazole-2-sulfonamide 0
                      5-methoxy-1,3,4-thiadiazol-2(3H)-one + 2
                      ICPD-26 0
                      ICPD-47 0
                      Methazolamide 8
                      N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide 8
                      N-(4-methyl-5-thiadiazolyl)carbamic acid 2-methylpropyl ester 0
                      N-methyl-N(alpha)-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)carbamoyl]-L-phenylalaninamide 0
                      acetazolamide + 65
                      benzyl \{(1R)-3-oxo-1-phenyl-3-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)amino]propyl\}carbamate 0
                      butazolamide 0
                      cefazedone 0
                      cefazolin 5
                      cefclidin 0
                      cefluprenam 0
                      cefozopran 0
                      ceftaroline + 0
                      ceftaroline fosamil + 0
                      ceftezole 0
                      ceftobiprole 0
                      ceftolozane 0
                      etridiazole 0
                      flufenacet 3
                      halicin 0
                      sulfamethizole 0
                      sulfametrole 0
                      thiadiazole + 75
                      thiadiazole antifungal agent + 0
                      thiadiazolecarboxylic acid + 0
                      tiadinil 0
                      timolol + 8
                      xanomeline 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic molecule 19493
                              organic cyclic compound 19318
                                organic heterocyclic compound 18510
                                  organic heteromonocyclic compound 16986
                                    thiadiazoles 92
                                      (2R,3R,4S,5R)-5-(3,4-dichlorophenyl)-5'-methyl-1',3'-dioxo-4-\{[4-(1,2,3-thiadiazol-4-yl)phenyl]carbamoyl\}-1',3',4,5-tetrahydro-3H-spiro[furan-2,2'-indene]-3-carboxylic acid 0
                                      (R)-1-amino-1-[5-(dimethylamino)-1,3,4-thiadiazol-2-yl]methanesulfonamide 0
                                      1,2,3-Thiadiazole, 5-methyl- 0
                                      1-(5-amino-1,3,4-thiadiazol-2-yl)-1,1-difluoromethanesulfonamide 0
                                      1-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-3-[1,1,1-trifluoro-2-(trifluoromethyl)butan-2-yl]urea 0
                                      1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-3-[1,1,1-trifluoro-2-(trifluoromethyl)butan-2-yl]urea 0
                                      1-butyl-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-4-hydroxy-2-oxoquinoline-3-carboxamide 0
                                      2,3,4,5,6-pentafluoro-N-methyl-N(alpha)-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)carbamoyl]-L-phenylalaninamide 0
                                      2-(acetylamino)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-3-ium 0
                                      2-amino-5-ethyl-1,3,4-thiadiazole 0
                                      3-(4-methyl-1,2,3-thiadiazolyl)-6-trichloromethyl[1,2,4]triazolo[3,4-b][1,3,4]thiadizole 0
                                      5-(2-phenylethyl)-1,3,4-thiadiazol-2-amine 0
                                      5-\{[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino\}-1,3,4-thiadiazole-2-sulfonamide 0
                                      5-amino-1,3,4-thiadiazole-2-sulfonamide 0
                                      5-methoxy-1,3,4-thiadiazol-2(3H)-one + 2
                                      ICPD-26 0
                                      ICPD-47 0
                                      Methazolamide 8
                                      N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide 8
                                      N-(4-methyl-5-thiadiazolyl)carbamic acid 2-methylpropyl ester 0
                                      N-methyl-N(alpha)-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)carbamoyl]-L-phenylalaninamide 0
                                      acetazolamide + 65
                                      benzyl \{(1R)-3-oxo-1-phenyl-3-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)amino]propyl\}carbamate 0
                                      butazolamide 0
                                      cefazedone 0
                                      cefazolin 5
                                      cefclidin 0
                                      cefluprenam 0
                                      cefozopran 0
                                      ceftaroline + 0
                                      ceftaroline fosamil + 0
                                      ceftezole 0
                                      ceftobiprole 0
                                      ceftolozane 0
                                      etridiazole 0
                                      flufenacet 3
                                      halicin 0
                                      sulfamethizole 0
                                      sulfametrole 0
                                      thiadiazole + 75
                                      thiadiazole antifungal agent + 0
                                      thiadiazolecarboxylic acid + 0
                                      tiadinil 0
                                      timolol + 8
                                      xanomeline 4
paths to the root