CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Lipa
lipase A, lysosomal acid type
multiple interactions
ISO
Thiadiazoles analog results in increased carbamoylation of and results in decreased activity of LIPA protein
CTD
PMID:20557099
NCBI chr 1:232,024,351...232,167,329
Ensembl chr 1:232,024,356...232,057,633
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Adrb1
adrenoceptor beta 1
multiple interactions
ISO
Timolol binds to and results in decreased activity of ADRB1 protein; Timolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]
CTD
PMID:11436944 PMID:15060759
NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
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Adrb2
adrenoceptor beta 2
multiple interactions
ISO
[Timolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; Timolol binds to and results in decreased activity of ADRB2 protein
CTD
PMID:11436944 PMID:17925438
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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Aoc1
amine oxidase, copper containing 1
multiple interactions
EXP
Timolol inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]
CTD
PMID:2860926
NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
affects response to substance
ISO
CYP2D6 gene SNP affects the susceptibility to Timolol
CTD
PMID:19284319 PMID:20925579
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO EXP
[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein] 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; [Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased phosphorylation of MAPK1 protein]; Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Gadolinium inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; W 7 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]
CTD
PMID:11914123 PMID:18977218
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO EXP
[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein] 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; [Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased phosphorylation of MAPK3 protein]; Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Gadolinium inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; W 7 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]
CTD
PMID:11914123 PMID:18977218
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Rgs3
regulator of G-protein signaling 3
multiple interactions
ISO
RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD
PMID:18977218
NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894
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Rgs4
regulator of G-protein signaling 4
multiple interactions
ISO
RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD
PMID:18977218
NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
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Abca1
ATP binding cassette subfamily A member 1
increases expression
ISO
Acetazolamide results in increased expression of ABCA1 mRNA
CTD
PMID:19274763
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Akap17a
A-kinase anchoring protein 17A
increases expression
ISO
Acetazolamide results in increased expression of AKAP17B mRNA
CTD
PMID:19274763
NCBI chr12:16,310,427...16,315,166
Ensembl chr12:16,310,437...16,314,479
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Akap9
A-kinase anchoring protein 9
increases expression
ISO
Acetazolamide results in increased expression of AKAP9 mRNA
CTD
PMID:19274763
NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606
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Ammecr1l
AMMECR1 like
increases expression
ISO
Acetazolamide results in increased expression of AMMECR1L mRNA
CTD
PMID:19274763
NCBI chr18:23,386,114...23,411,177
Ensembl chr18:23,386,903...23,410,920
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Anp32a
acidic nuclear phosphoprotein 32 family member A
increases expression
ISO
Acetazolamide results in increased expression of ANP32A mRNA
CTD
PMID:19274763
Ensembl chr 8:62,827,456...62,865,443
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Aqp1
aquaporin 1
decreases expression
ISO
Acetazolamide results in decreased expression of AQP1 protein
CTD
PMID:17219999
NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
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Arhgap45
Rho GTPase activating protein 45
affects expression
ISO
Acetazolamide affects the expression of ARHGAP45 mRNA
CTD
PMID:25811541
NCBI chr 7:9,674,873...9,690,286
Ensembl chr 7:9,674,897...9,690,268
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Arid2
AT-rich interaction domain 2
increases expression
ISO
Acetazolamide results in increased expression of ARID2 mRNA
CTD
PMID:19274763
NCBI chr 7:127,447,192...127,565,987
Ensembl chr 7:127,447,278...127,563,512
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Brd4
bromodomain containing 4
increases expression
ISO
Acetazolamide results in increased expression of BRD4 mRNA
CTD
PMID:19274763
NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539
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Car1
carbonic anhydrase 1
multiple interactions decreases activity
ISO
Acetazolamide binds to and results in decreased activity of CA1 protein; Indomethacin inhibits the reaction [Acetazolamide results in decreased activity of CA1 protein]
CTD
PMID:11430635 PMID:17826101 PMID:19231207 PMID:28117934 PMID:28251759 PMID:29131470 PMID:29283199 PMID:29457667 PMID:29975450 PMID:29992664 PMID:30291660 PMID:30368973 PMID:30431690 PMID:30537031 More...
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
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Car12
carbonic anhydrase 12
decreases activity multiple interactions
ISO
Acetazolamide results in decreased activity of CA12 protein Acetazolamide binds to and results in decreased activity of CA12 protein
CTD
PMID:21851094 PMID:28251759
NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440
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Car13
carbonic anhydrase 13
multiple interactions
ISO
Acetazolamide binds to and results in decreased activity of CA13 protein
CTD
PMID:28251759
NCBI chr 2:86,928,401...86,959,525
Ensembl chr 2:86,928,383...86,959,525
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Car14
carbonic anhydrase 14
multiple interactions
ISO
Acetazolamide binds to and results in decreased activity of CA14 protein
CTD
PMID:28251759
NCBI chr 2:183,442,263...183,449,207
Ensembl chr 2:183,441,667...183,449,693
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Car2
carbonic anhydrase 2
multiple interactions decreases activity
ISO
Acetazolamide binds to and results in decreased activity of CA2 protein; Indomethacin inhibits the reaction [Acetazolamide results in decreased activity of CA2 protein]
CTD
PMID:11430635 PMID:16858005 PMID:17826101 PMID:19231207 PMID:21851094 PMID:28117934 PMID:28251759 PMID:29131470 PMID:29283199 PMID:29457667 PMID:29975450 PMID:29992664 PMID:30291660 PMID:30368973 PMID:30431690 PMID:30537031 More...
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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Car3
carbonic anhydrase 3
multiple interactions
ISO
Acetazolamide binds to and results in decreased activity of CA3 protein
CTD
PMID:17826101
NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
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Car4
carbonic anhydrase 4
multiple interactions
ISO
Acetazolamide binds to and results in decreased activity of CA4 protein
CTD
PMID:28251759
NCBI chr10:69,827,945...69,836,501
Ensembl chr10:69,827,945...69,836,501
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Car5a
carbonic anhydrase 5A
multiple interactions
ISO
Acetazolamide binds to and results in decreased activity of CA5A protein
CTD
PMID:28251759
NCBI chr19:49,973,092...50,002,948
Ensembl chr19:49,973,107...50,002,906
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Car5b
carbonic anhydrase 5B
multiple interactions
ISO
Acetazolamide binds to and results in decreased activity of CA5B protein
CTD
PMID:28251759
NCBI chr X:30,474,697...30,534,797
Ensembl chr X:30,474,784...30,533,837
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Car6
carbonic anhydrase 6
multiple interactions
ISO
Acetazolamide binds to and results in decreased activity of CA6 protein
CTD
PMID:28251759
NCBI chr 5:160,658,104...160,676,644
Ensembl chr 5:160,658,105...160,676,644
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Car7
carbonic anhydrase 7
multiple interactions
ISO
Acetazolamide binds to and results in decreased activity of CA7 protein
CTD
PMID:28251759
NCBI chr19:429,063...438,478
Ensembl chr19:429,075...438,467
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Car9
carbonic anhydrase 9
decreases activity multiple interactions
ISO
Acetazolamide results in decreased activity of CA9 protein Acetazolamide binds to and results in decreased activity of CA9 protein
CTD
PMID:21851094 PMID:28251759
NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
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Casp3
caspase 3
multiple interactions
ISO
Acetazolamide promotes the reaction [bleomycetin results in increased activity of CASP3 protein]
CTD
PMID:21040473
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cbx3
chromobox 3
increases expression
ISO
Acetazolamide results in increased expression of CBX3 mRNA
CTD
PMID:19274763
NCBI chr 4:80,545,450...80,559,284
Ensembl chr 4:80,546,010...80,559,283
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Ccnd2
cyclin D2
increases expression
ISO
Acetazolamide results in increased expression of CCND2 mRNA
CTD
PMID:19274763
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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Cd47
Cd47 molecule
increases expression
ISO
Acetazolamide results in increased expression of CD47 mRNA
CTD
PMID:19274763
NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
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Cirbp
cold inducible RNA binding protein
increases expression
ISO
Acetazolamide results in increased expression of CIRBP mRNA
CTD
PMID:19274763
NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818
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Clcn3
chloride voltage-gated channel 3
increases expression
ISO
Acetazolamide results in increased expression of CLCN3 mRNA
CTD
PMID:19274763
NCBI chr16:29,127,419...29,200,133
Ensembl chr16:29,127,419...29,200,119
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Ddx3x
DEAD-box helicase 3, X-linked
increases expression
ISO
Acetazolamide results in increased expression of DDX3X mRNA
CTD
PMID:19274763
NCBI chr X:9,479,532...9,493,455
Ensembl chr X:9,479,532...9,493,168
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Ddx6
DEAD-box helicase 6
increases expression
ISO
Acetazolamide results in increased expression of DDX6 mRNA
CTD
PMID:19274763
NCBI chr 8:44,931,127...44,967,773
Ensembl chr 8:44,931,974...44,964,405
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Dsc2
desmocollin 2
increases expression
ISO
Acetazolamide results in increased expression of DSC2 mRNA
CTD
PMID:19274763
NCBI chr18:11,450,392...11,482,476
Ensembl chr18:11,450,390...11,482,392
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Glg1
golgi glycoprotein 1
increases expression
ISO
Acetazolamide results in increased expression of GLG1 mRNA
CTD
PMID:19274763
NCBI chr19:39,124,892...39,224,178
Ensembl chr19:39,124,641...39,224,178
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Glul
glutamate-ammonia ligase
increases expression
ISO
Acetazolamide results in increased expression of GLUL mRNA
CTD
PMID:19274763
NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
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Htra1
HtrA serine peptidase 1
increases expression
ISO
Acetazolamide results in increased expression of HTRA1 mRNA
CTD
PMID:19274763
NCBI chr 1:185,497,815...185,547,380
Ensembl chr 1:185,497,735...185,547,379
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Igf1r
insulin-like growth factor 1 receptor
increases expression
ISO
Acetazolamide results in increased expression of IGF1R mRNA
CTD
PMID:19274763
NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
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Itpr2
inositol 1,4,5-trisphosphate receptor, type 2
increases expression
ISO
Acetazolamide results in increased expression of ITPR2 mRNA
CTD
PMID:19274763
NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164
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LOC102546572
zinc finger protein 709-like
increases expression
ISO
Acetazolamide results in increased expression of ZFP617 mRNA
CTD
PMID:19274763
NCBI chr 7:11,846,077...11,868,732
Ensembl chr 7:11,845,560...11,868,717
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Mab21l2
mab-21 like 2
decreases expression
ISO
Acetazolamide results in decreased expression of MAB21L2 mRNA
CTD
PMID:19274763
NCBI chr 2:171,946,573...171,949,655
Ensembl chr 2:171,946,573...171,949,655
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Map3k1
mitogen-activated protein kinase kinase kinase 1
increases expression
ISO
Acetazolamide results in increased expression of MAP3K1 mRNA
CTD
PMID:19274763
NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
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Mt1
metallothionein 1
decreases expression
ISO
Acetazolamide results in decreased expression of MT1 mRNA
CTD
PMID:19274763
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
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Naa15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
increases expression
ISO
Acetazolamide results in increased expression of NAA15 mRNA
CTD
PMID:19274763
NCBI chr 2:135,458,018...135,520,756
Ensembl chr 2:135,457,948...135,520,756
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Ndrg1
N-myc downstream regulated 1
increases expression
ISO
Acetazolamide results in increased expression of NDRG1 mRNA
CTD
PMID:19274763
NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
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Nrip1
nuclear receptor interacting protein 1
increases expression
ISO
Acetazolamide results in increased expression of NRIP1 mRNA
CTD
PMID:19274763
NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
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Peg3
paternally expressed 3
increases expression
ISO
Acetazolamide results in increased expression of PEG3 mRNA
CTD
PMID:19274763
NCBI chr 1:67,097,874...67,124,692
Ensembl chr 1:67,097,904...67,124,671
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Pou2f1
POU class 2 homeobox 1
increases expression
ISO
Acetazolamide results in increased expression of POU2F1 mRNA
CTD
PMID:19274763
NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363
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Ppm1b
protein phosphatase, Mg2+/Mn2+ dependent, 1B
increases expression
ISO
Acetazolamide results in increased expression of PPM1B mRNA
CTD
PMID:19274763
NCBI chr 6:9,646,695...9,707,471
Ensembl chr 6:9,655,765...9,707,974
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Ppp3ca
protein phosphatase 3 catalytic subunit alpha
increases expression
ISO
Acetazolamide results in increased expression of PPP3CA mRNA
CTD
PMID:19274763
NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
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Rbm39
RNA binding motif protein 39
increases expression
ISO
Acetazolamide results in increased expression of RBM39 mRNA
CTD
PMID:19274763
NCBI chr 3:144,662,998...144,696,222
Ensembl chr 3:144,663,001...144,696,213
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Rbmx
RNA binding motif protein, X-linked
increases expression
ISO
Acetazolamide results in increased expression of RBMX mRNA
CTD
PMID:19274763
NCBI chr X:135,305,237...135,314,806
Ensembl chr X:135,305,325...135,314,743
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Satb1
SATB homeobox 1
increases expression
ISO
Acetazolamide results in increased expression of SATB1 mRNA
CTD
PMID:19274763
NCBI chr 9:4,677,817...4,773,061
Ensembl chr 9:4,680,920...4,753,251
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Sc5d
sterol-C5-desaturase
increases expression
ISO
Acetazolamide results in increased expression of SC5D mRNA
CTD
PMID:19274763
NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
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Schip1
schwannomin interacting protein 1
increases expression
ISO
Acetazolamide results in increased expression of SCHIP1 mRNA
CTD
PMID:19274763
NCBI chr 2:152,127,171...152,888,587
Ensembl chr 2:152,126,953...152,888,585
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Sdc4
syndecan 4
increases expression
ISO
Acetazolamide results in increased expression of SDC4 mRNA
CTD
PMID:19274763
NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580
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Sema4b
semaphorin 4B
increases expression
ISO
Acetazolamide results in increased expression of SEMA4B mRNA
CTD
PMID:19274763
NCBI chr 1:134,136,646...134,177,777
Ensembl chr 1:134,149,536...134,177,775
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Sf3b1
splicing factor 3b, subunit 1
increases expression
ISO
Acetazolamide results in increased expression of SF3B1 mRNA
CTD
PMID:19274763
NCBI chr 9:56,492,403...56,532,300
Ensembl chr 9:56,492,403...56,532,300
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Sfmbt2
Scm-like with four mbt domains 2
increases expression
ISO
Acetazolamide results in increased expression of SFMBT2 mRNA
CTD
PMID:19274763
NCBI chr17:67,934,296...68,128,905
Ensembl chr17:67,935,904...68,128,781
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Shox2
short stature homeobox 2
increases expression
ISO
Acetazolamide results in increased expression of SHOX2 mRNA
CTD
PMID:19274763
NCBI chr 2:151,217,049...151,227,180
Ensembl chr 2:151,217,552...151,227,143
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Smarcc1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
increases expression
ISO
Acetazolamide results in increased expression of SMARCC1 mRNA
CTD
PMID:19274763
NCBI chr 8:110,111,097...110,214,727
Ensembl chr 8:110,111,122...110,214,720
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Stx3
syntaxin 3
increases expression
ISO
Acetazolamide results in increased expression of STX3 mRNA
CTD
PMID:19274763
NCBI chr 1:208,617,018...208,686,240
Ensembl chr 1:208,639,115...208,685,805
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Styx
serine/threonine/tyrosine interacting protein
increases expression
ISO
Acetazolamide results in increased expression of STYX mRNA
CTD
PMID:19274763
NCBI chr15:18,565,214...18,595,797
Ensembl chr15:18,564,633...18,593,524
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Tia1
TIA1 cytotoxic granule-associated RNA binding protein
increases expression
ISO
Acetazolamide results in increased expression of TIA1 mRNA
CTD
PMID:19274763
NCBI chr 4:118,852,765...118,883,252
Ensembl chr 4:118,852,837...118,880,586
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Tmem30b
transmembrane protein 30B
increases expression
ISO
Acetazolamide results in increased expression of TMEM30B mRNA
CTD
PMID:19274763
NCBI chr 6:92,251,626...92,254,702
Ensembl chr 6:92,249,790...92,254,842
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Trim25
tripartite motif-containing 25
increases expression
ISO
Acetazolamide results in increased expression of TRIM25 mRNA
CTD
PMID:19274763
NCBI chr10:73,812,818...73,831,271
Ensembl chr10:73,812,818...73,831,257
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Umod
uromodulin
increases expression
ISO
Acetazolamide results in increased expression of UMOD protein
CTD
PMID:2655449
NCBI chr 1:173,816,341...173,829,681
Ensembl chr 1:173,816,339...173,830,302
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Wnk1
WNK lysine deficient protein kinase 1
increases expression
ISO
Acetazolamide results in increased expression of WNK1 mRNA
CTD
PMID:19274763
NCBI chr 4:153,128,334...153,253,905
Ensembl chr 4:153,128,334...153,253,905
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Zfp322a
zinc finger protein 322a
increases expression
ISO
Acetazolamide results in increased expression of ZFP322A mRNA
CTD
PMID:19274763
NCBI chr17:41,773,789...41,789,654
Ensembl chr17:41,773,782...41,790,078
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Dhfr
dihydrofolate reductase
decreases activity
ISO
Cefazolin results in decreased activity of DHFR protein
CTD
PMID:25418905
NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
G
Gsr
glutathione-disulfide reductase
multiple interactions increases expression
ISO
Cefazolin results in increased expression of and results in decreased activity of GSR protein Cefazolin results in increased expression of GSR mRNA
CTD
PMID:32196862
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
RT1-DOa
RT1 class II, locus DOa
affects expression
ISO
Cefazolin affects the expression of HLA-DOA mRNA
CTD
PMID:25811541
NCBI chr20:4,753,587...4,756,590
Ensembl chr20:4,753,598...4,756,577
G
RT1-M3-1
RT1 class Ib, locus M3, gene 1
affects expression
ISO
Cefazolin affects the expression of HLA-G mRNA
CTD
PMID:25811541
NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
G
Slc22a8
solute carrier family 22 member 8
increases uptake
ISO
SLC22A8 protein results in increased uptake of Cefazolin
CTD
PMID:16098483
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
G
Slc25a20
solute carrier family 25 member 20
multiple interactions
EXP
Cefazolin binds to and results in decreased activity of SLC25A20 protein; Cefazolin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine]
CTD
PMID:18452908
NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512
G
Nfe2l2
NFE2 like bZIP transcription factor 2
increases activity
ISO
FOE 5043 results in increased activity of NFE2L2 protein
CTD
PMID:20143881
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity affects activity
ISO
FOE 5043 results in increased activity of NR1I2 protein FOE 5043 affects the activity of NR1I2 protein
CTD
PMID:20143881 PMID:23611293
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Tspo
translocator protein
affects activity
EXP
FOE 5043 affects the activity of TSPO protein
CTD
PMID:23611293
NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
G
Car1
carbonic anhydrase 1
multiple interactions
ISO
Methazolamide binds to and results in decreased activity of CA1 protein
CTD
PMID:17826101
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
G
Car2
carbonic anhydrase 2
decreases activity multiple interactions
ISO
Methazolamide results in decreased activity of CA2 protein Methazolamide binds to and results in decreased activity of CA2 protein
CTD
PMID:16858005 PMID:17826101
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
G
Car3
carbonic anhydrase 3
multiple interactions
ISO
Methazolamide binds to and results in decreased activity of CA3 protein
CTD
PMID:17826101
NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
G
Clu
clusterin
affects expression
ISO
Methazolamide affects the expression of CLU protein
CTD
PMID:12388792
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
G
Gal
galanin and GMAP prepropeptide
affects expression
ISO
Methazolamide affects the expression of GAL protein
CTD
PMID:12388792
NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
G
Gap43
growth associated protein 43
affects expression
ISO
Methazolamide affects the expression of GAP43 protein
CTD
PMID:12388792
NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
G
Ret
ret proto-oncogene
affects expression
ISO
Methazolamide affects the expression of RET protein
CTD
PMID:12388792
NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
G
Timp1
TIMP metallopeptidase inhibitor 1
affects expression
ISO
Methazolamide affects the expression of TIMP1 protein
CTD
PMID:12388792
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
[enilconazole co-treated with methidathion] results in increased expression of CYP3A4 mRNA
CTD
PMID:25028461
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
[enilconazole co-treated with methidathion] results in increased activity of NR1I2 protein
CTD
PMID:25028461
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Car1
carbonic anhydrase 1
multiple interactions
ISO
Methazolamide binds to and results in decreased activity of CA1 protein
CTD
PMID:17826101
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
G
Car2
carbonic anhydrase 2
multiple interactions decreases activity
ISO
Methazolamide binds to and results in decreased activity of CA2 protein Methazolamide results in decreased activity of CA2 protein
CTD
PMID:16858005 PMID:17826101
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
G
Car3
carbonic anhydrase 3
multiple interactions
ISO
Methazolamide binds to and results in decreased activity of CA3 protein
CTD
PMID:17826101
NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
G
Clu
clusterin
affects expression
ISO
Methazolamide affects the expression of CLU protein
CTD
PMID:12388792
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
G
Gal
galanin and GMAP prepropeptide
affects expression
ISO
Methazolamide affects the expression of GAL protein
CTD
PMID:12388792
NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
G
Gap43
growth associated protein 43
affects expression
ISO
Methazolamide affects the expression of GAP43 protein
CTD
PMID:12388792
NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
G
Ret
ret proto-oncogene
affects expression
ISO
Methazolamide affects the expression of RET protein
CTD
PMID:12388792
NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
G
Timp1
TIMP metallopeptidase inhibitor 1
affects expression
ISO
Methazolamide affects the expression of TIMP1 protein
CTD
PMID:12388792
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
G
Chrm1
cholinergic receptor, muscarinic 1
increases response to substance multiple interactions
ISO EXP
CHRM1 gene results in increased susceptibility to xanomeline; CHRM1 results in increased susceptibility to xanomeline xanomeline binds to and results in increased activity of [CHRM1 protein binds to CHRM4 protein]
CTD
PMID:19111716 PMID:19996296 PMID:21211109
NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
G
Chrm4
cholinergic receptor, muscarinic 4
affects binding multiple interactions increases response to substance
ISO EXP
xanomeline binds to CHRM4 protein xanomeline binds to and results in increased activity of [CHRM1 protein binds to CHRM4 protein] [WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [xanomeline binds to CHRM4 protein] CHRM4 gene results in increased susceptibility to xanomeline; CHRM4 results in increased susceptibility to xanomeline
CTD
PMID:16709648 PMID:19111716 PMID:19996296 PMID:21211109
NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
G
Egr1
early growth response 1
increases expression
EXP
xanomeline results in increased expression of EGR1 mRNA
CTD
PMID:11313039
NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
EXP
xanomeline results in increased expression of FOS mRNA
CTD
PMID:11313039
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
20083
chemical entity
20082
atom
20081
nonmetal atom
19971
carbon atom
19902
organic molecular entity
19902
heteroorganic entity
19585
organic heterocyclic compound
18824
organic heteromonocyclic compound
17173
thiadiazoles
93
(2R,3R,4S,5R)-5-(3,4-dichlorophenyl)-5'-methyl-1',3'-dioxo-4-\{[4-(1,2,3-thiadiazol-4-yl)phenyl]carbamoyl\}-1',3',4,5-tetrahydro-3H-spiro[furan-2,2'-indene]-3-carboxylic acid
0
(R)-1-amino-1-[5-(dimethylamino)-1,3,4-thiadiazol-2-yl]methanesulfonamide
0
1,2,3-Thiadiazole, 5-methyl-
0
1-(5-amino-1,3,4-thiadiazol-2-yl)-1,1-difluoromethanesulfonamide
0
1-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-3-[1,1,1-trifluoro-2-(trifluoromethyl)butan-2-yl]urea
0
1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-3-[1,1,1-trifluoro-2-(trifluoromethyl)butan-2-yl]urea
0
1-butyl-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-4-hydroxy-2-oxoquinoline-3-carboxamide
0
2,3,4,5,6-pentafluoro-N-methyl-N(alpha)-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)carbamoyl]-L-phenylalaninamide
0
2-(acetylamino)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-3-ium
0
2-amino-5-ethyl-1,3,4-thiadiazole
0
3-(4-methyl-1,2,3-thiadiazolyl)-6-trichloromethyl[1,2,4]triazolo[3,4-b][1,3,4]thiadizole
0
5-(2-phenylethyl)-1,3,4-thiadiazol-2-amine
0
5-\{[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino\}-1,3,4-thiadiazole-2-sulfonamide
0
5-amino-1,3,4-thiadiazole-2-sulfonamide
0
5-methoxy-1,3,4-thiadiazol-2(3H)-one +
2
ICPD-26
0
ICPD-47
0
Methazolamide
8
N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide
8
N-(4-methyl-5-thiadiazolyl)carbamic acid 2-methylpropyl ester
0
N-methyl-N(alpha)-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)carbamoyl]-L-phenylalaninamide
0
acetazolamide +
65
benzyl \{(1R)-3-oxo-1-phenyl-3-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)amino]propyl\}carbamate
0
butazolamide
0
cefazedone
0
cefazolin
6
cefclidin
0
cefluprenam
0
cefozopran
0
ceftaroline +
0
ceftaroline fosamil +
0
ceftezole
0
ceftobiprole
0
ceftolozane
0
etridiazole
0
flufenacet
3
halicin
0
sulfamethizole
0
sulfametrole
0
thiadiazole +
75
thiadiazole antifungal agent +
0
thiadiazolecarboxylic acid +
0
tiadinil
0
timolol +
8
xanomeline
4
Path 2
CHEBI ontology
20083
subatomic particle
20081
composite particle
20081
hadron
20081
baryon
20081
nucleon
20081
atomic nucleus
20081
atom
20081
main group element atom
19982
p-block element atom
19982
carbon group element atom
19909
carbon atom
19902
organic molecular entity
19902
organic molecule
19849
organic cyclic compound
19604
organic heterocyclic compound
18824
organic heteromonocyclic compound
17173
thiadiazoles
93
(2R,3R,4S,5R)-5-(3,4-dichlorophenyl)-5'-methyl-1',3'-dioxo-4-\{[4-(1,2,3-thiadiazol-4-yl)phenyl]carbamoyl\}-1',3',4,5-tetrahydro-3H-spiro[furan-2,2'-indene]-3-carboxylic acid
0
(R)-1-amino-1-[5-(dimethylamino)-1,3,4-thiadiazol-2-yl]methanesulfonamide
0
1,2,3-Thiadiazole, 5-methyl-
0
1-(5-amino-1,3,4-thiadiazol-2-yl)-1,1-difluoromethanesulfonamide
0
1-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-3-[1,1,1-trifluoro-2-(trifluoromethyl)butan-2-yl]urea
0
1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-3-[1,1,1-trifluoro-2-(trifluoromethyl)butan-2-yl]urea
0
1-butyl-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-4-hydroxy-2-oxoquinoline-3-carboxamide
0
2,3,4,5,6-pentafluoro-N-methyl-N(alpha)-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)carbamoyl]-L-phenylalaninamide
0
2-(acetylamino)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-3-ium
0
2-amino-5-ethyl-1,3,4-thiadiazole
0
3-(4-methyl-1,2,3-thiadiazolyl)-6-trichloromethyl[1,2,4]triazolo[3,4-b][1,3,4]thiadizole
0
5-(2-phenylethyl)-1,3,4-thiadiazol-2-amine
0
5-\{[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino\}-1,3,4-thiadiazole-2-sulfonamide
0
5-amino-1,3,4-thiadiazole-2-sulfonamide
0
5-methoxy-1,3,4-thiadiazol-2(3H)-one +
2
ICPD-26
0
ICPD-47
0
Methazolamide
8
N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide
8
N-(4-methyl-5-thiadiazolyl)carbamic acid 2-methylpropyl ester
0
N-methyl-N(alpha)-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)carbamoyl]-L-phenylalaninamide
0
acetazolamide +
65
benzyl \{(1R)-3-oxo-1-phenyl-3-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)amino]propyl\}carbamate
0
butazolamide
0
cefazedone
0
cefazolin
6
cefclidin
0
cefluprenam
0
cefozopran
0
ceftaroline +
0
ceftaroline fosamil +
0
ceftezole
0
ceftobiprole
0
ceftolozane
0
etridiazole
0
flufenacet
3
halicin
0
sulfamethizole
0
sulfametrole
0
thiadiazole +
75
thiadiazole antifungal agent +
0
thiadiazolecarboxylic acid +
0
tiadinil
0
timolol +
8
xanomeline
4