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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:15-hydroxy steroid
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Accession:CHEBI:38089 term browser browse the term
Definition:A hydroxy steroid carrying a hydroxy group at position 15.
Synonyms:related_synonym: 15-hydroxy steroids


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15alpha-hydroxytestosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO [[ABCC1 gene mutant form results in increased susceptibility to Testosterone deficiency] which results in decreased hydroxylation of Testosterone] which results in decreased chemical synthesis of 15-hydroxytestosterone CTD PMID:22522787 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
andrastin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf2 colony stimulating factor 2 multiple interactions ISO andrastin A results in increased expression of and results in increased secretion of CSF2 protein CTD PMID:28535995 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO andrastin A results in increased expression of and results in increased secretion of TGFB1 protein CTD PMID:28535995 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO andrastin A results in increased expression of and results in increased secretion of TNF protein CTD PMID:28535995 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
digitonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh5 cadherin 5 multiple interactions ISO Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein] CTD PMID:31404653 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368 		JBrowse link
G Etv2 ETS variant transcription factor 2 multiple interactions ISO Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] CTD PMID:31404653 NCBI chr 1:85,890,562...85,894,025
Ensembl chr 1:85,890,559...85,893,431 		JBrowse link
G Gata2 GATA binding protein 2 multiple interactions ISO Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] CTD PMID:31404653 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO Digitonin results in decreased expression of HIF1A protein CTD PMID:34717917 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Digitonin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Spn sialophorin multiple interactions ISO Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] CTD PMID:31404653 NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    chemical entity 20088
      molecular entity 20058
        polyatomic entity 20018
          heteroatomic molecular entity 19924
            hydroxides 19454
              organic hydroxy compound 19017
                hydroxy steroid 14111
                  15-hydroxy steroid 10
                    15alpha-hydroxy steroid + 1
                    15beta-hydroxy steroid + 6
                    andrastin A 3
                    andrastin B + 3
                    andrastin C + 3
                    andrastin D + 0
                    andrastin E 0
                    andrastin F 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic polycyclic compound 17201
                                  steroid 14380
                                    hydroxy steroid 14111
                                      15-hydroxy steroid 10
                                        15alpha-hydroxy steroid + 1
                                        15beta-hydroxy steroid + 6
                                        andrastin A 3
                                        andrastin B + 3
                                        andrastin C + 3
                                        andrastin D + 0
                                        andrastin E 0
                                        andrastin F 0
paths to the root