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ONTOLOGY REPORT - ANNOTATIONS


Term:2-benzofuran-1(3H)-one
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Accession:CHEBI:38085 term browser browse the term
Definition:A gamma-lactone that is 1,3-dihydro-2-benzofuran in which the hydrogens at position 1 are replaced by an oxo group.
Synonyms:related_synonym: 1(3H)-isobenzofuranone;   1-Phthalanone;   2-Hydroxymethylbenzoic acid, gamma-lactone;   3-oxo-1,3-dihydro-isobenzofuran;   Formula=C8H6O2;   InChI=1S/C8H6O2/c9-8-7-4-2-1-3-6(7)5-10-8/h1-4H,5H2;   InChIKey=WNZQDUSMALZDQF-UHFFFAOYSA-N;   Phthalolactone;   SMILES=O=C1OCc2ccccc12;   isobenzofuranone;   phthalide
 xref: CAS:87-41-2 "ChemIDplus";   CAS:87-41-2 "NIST Chemistry WebBook";   HMDB:HMDB0032469;   PMID:23462848 "Europe PMC";   Reaxys:114632 "Reaxys";   Wikipedia:Phthalide


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(Z)-3-butylidenephthalide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Aifm1 apoptosis inducing factor, mitochondria associated 1 JBrowse link X 135,304,063 135,343,062 RGD:6480464
G Anxa5 annexin A5 JBrowse link 2 123,162,477 123,194,730 RGD:6480464
G Arhgap1 Rho GTPase activating protein 1 JBrowse link 3 80,555,196 80,576,881 RGD:6480464
G Arhgdia Rho GDP dissociation inhibitor alpha JBrowse link 10 109,754,012 109,757,506 RGD:6480464
G Atp5f1a ATP synthase F1 subunit alpha JBrowse link 18 74,156,553 74,164,490 RGD:6480464
G Atp5f1b ATP synthase F1 subunit beta JBrowse link 7 2,504,708 2,511,748 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bik BCL2-interacting killer JBrowse link 7 124,390,924 124,410,449 RGD:6480464
G C1qbp complement C1q binding protein JBrowse link 10 57,613,876 57,618,527 RGD:6480464
G Calr calreticulin JBrowse link 19 25,956,771 25,961,666 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Ccne1 cyclin E1 JBrowse link 1 94,485,830 94,495,112 RGD:6480464
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6480464
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6480464
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6480464
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:6480464
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 JBrowse link 8 85,838,594 85,841,816 RGD:6480464
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 JBrowse link 3 176,657,104 176,666,282 RGD:6480464
G Eef2 eukaryotic translation elongation factor 2 JBrowse link 7 11,401,501 11,406,771 RGD:6480464
G Eif4a1 eukaryotic translation initiation factor 4A1 JBrowse link 10 56,271,257 56,276,764 RGD:6480464
G Elavl1 ELAV like RNA binding protein 1 JBrowse link 12 2,461,502 2,502,432 RGD:6480464
G Eno1 enolase 1 JBrowse link 5 167,288,223 167,299,610 RGD:6480464
G Ern1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 10 94,588,555 94,682,072 RGD:6480464
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6480464
G Fus FUS RNA binding protein JBrowse link 1 199,412,805 199,426,705 RGD:6480464
G Got1 glutamic-oxaloacetic transaminase 1 JBrowse link 1 263,246,248 263,269,762 RGD:6480464
G Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 JBrowse link 3 62,481,222 62,491,356 RGD:6480464
G Hnrnpd heterogeneous nuclear ribonucleoprotein D JBrowse link 14 11,256,163 11,274,684 RGD:6480464
G Hnrnpf heterogeneous nuclear ribonucleoprotein F JBrowse link 4 149,957,143 149,978,896 RGD:6480464
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:6480464
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:6480464
G Ldha lactate dehydrogenase A JBrowse link 1 102,900,288 102,909,713 RGD:6480464
G Mif macrophage migration inhibitory factor JBrowse link 20 13,715,219 13,732,980 RGD:6480464
G Mki67 marker of proliferation Ki-67 JBrowse link 1 207,993,895 208,020,454 RGD:6480464
G Ncl nucleolin JBrowse link 9 93,369,119 93,377,643 RGD:6480464
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 JBrowse link 10 81,657,152 81,666,542 RGD:6480464
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:6480464
G Pgk1 phosphoglycerate kinase 1 JBrowse link X 77,263,399 77,279,373 RGD:6480464
G Phb prohibitin JBrowse link 10 83,476,107 83,488,878 RGD:6480464
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha JBrowse link 1 60,717,386 60,736,629 RGD:6480464
G Prps1 phosphoribosyl pyrophosphate synthetase 1 JBrowse link X 111,798,233 111,820,270 RGD:6480464
G Psma1 proteasome 20S subunit alpha 1 JBrowse link 1 183,733,567 183,744,586 RGD:6480464
G Psmd11 proteasome 26S subunit, non-ATPase 11 JBrowse link 10 67,810,655 67,857,562 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Rpsa ribosomal protein SA JBrowse link 8 128,806,053 128,809,987 RGD:6480464
G Sf3b3 splicing factor 3b, subunit 3 JBrowse link 19 43,392,071 43,429,582 RGD:6480464
G Sfn stratifin JBrowse link 5 151,823,422 151,824,937 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Tpt1 tumor protein, translationally-controlled 1 JBrowse link 15 57,891,680 57,894,504 RGD:6480464
G Tufm Tu translation elongation factor, mitochondrial JBrowse link 1 197,903,582 197,907,189 RGD:6480464
G Was WASP actin nucleation promoting factor JBrowse link X 15,155,246 15,164,099 RGD:6480464
G Ybx1 Y box binding protein 1 JBrowse link 5 138,319,754 138,336,721 RGD:6480464
bromosulfophthalein term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb4 ATP binding cassette subfamily B member 4 JBrowse link 4 22,133,984 22,192,687 RGD:6480464
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Cck cholecystokinin JBrowse link 8 130,120,525 130,127,515 RGD:6480464
G Gsta1 glutathione S-transferase alpha 1 JBrowse link 9 27,366,404 27,381,004 RGD:6480464
G Gsta3 glutathione S-transferase alpha 3 JBrowse link 9 27,357,490 27,417,023 RGD:6480464
G Gstm2 glutathione S-transferase mu 2 JBrowse link 2 210,778,041 210,782,807 RGD:6480464
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6480464
G Keap1 Kelch-like ECH-associated protein 1 JBrowse link 8 22,250,518 22,259,868 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Slc10a1 solute carrier family 10 member 1 JBrowse link 6 104,617,730 104,631,355 RGD:6480464
G Slc16a2 solute carrier family 16 member 2 JBrowse link X 74,578,600 74,706,068 RGD:6480464
G Slc19a1 solute carrier family 19 member 1 JBrowse link 20 12,334,675 12,354,517 RGD:6480464
G Slc22a6 solute carrier family 22 member 6 JBrowse link 1 224,824,809 224,833,284 RGD:6480464
G Slc22a7 solute carrier family 22 member 7 JBrowse link 9 16,925,321 16,931,119 RGD:6480464
G Slc22a8 solute carrier family 22 member 8 JBrowse link 1 224,799,444 224,818,482 RGD:6480464
G Slc46a1 solute carrier family 46 member 1 JBrowse link 10 65,728,508 65,741,708 RGD:6480464
G Slco1b2 solute carrier organic anion transporter family, member 1B2 JBrowse link 4 175,814,118 175,881,775 RGD:6480464
G Slco2b1 solute carrier organic anion transporter family, member 2b1 JBrowse link 1 164,623,313 164,671,612 RGD:6480464
phenolphthalein term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1c1 aldo-keto reductase family 1, member C1 JBrowse link 17 69,441,253 69,460,334 RGD:6480464
G Akr1c2 aldo-keto reductase family 1, member C2 JBrowse link 17 69,388,337 69,435,160 RGD:6480464
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 13 89,585,072 89,591,278 RGD:6480464
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:6480464
G Shbg sex hormone binding globulin JBrowse link 10 56,219,861 56,237,354 RGD:6480464
G Tyms thymidylate synthetase JBrowse link 9 121,918,875 121,931,564 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    chemical entity 19667
      group 19582
        inorganic group 19022
          oxo group 18222
            organic oxo compound 18222
              carbonyl compound 18222
                carboxylic ester 13934
                  lactone 5859
                    gamma-lactone 1192
                      2-benzofuran-1(3H)-one 91
                        (Z)-3-butylidene-7-hydroxyphthalide 0
                        (Z)-3-butylidenephthalide 61
                        4,5,6,7-tetrachloro-2-benzofuran-1(3H)-one 0
                        bromosulfophthalein 20
                        bromosulfophthalein sodium 0
                        phenolphthalein 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic ester 13934
                                        lactone 5859
                                          gamma-lactone 1192
                                            2-benzofuran-1(3H)-one 91
                                              (Z)-3-butylidene-7-hydroxyphthalide 0
                                              (Z)-3-butylidenephthalide 61
                                              4,5,6,7-tetrachloro-2-benzofuran-1(3H)-one 0
                                              bromosulfophthalein 20
                                              bromosulfophthalein sodium 0
                                              phenolphthalein 10
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.