|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
[butylidenephthalide co-treated with ligustilide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; butylidenephthalide inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] |
CTD |
PMID:29191726 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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|
G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
increases expression |
EXP ISO |
butylidenephthalide results in increased expression of AIFM1 protein |
CTD |
PMID:16987298 PMID:23770345 |
|
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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|
G |
Anxa5 |
annexin A5 |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of ANXA5 protein |
CTD |
PMID:23770345 |
|
NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
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|
G |
Arhgap1 |
Rho GTPase activating protein 1 |
increases expression |
ISO |
butylidenephthalide results in increased expression of ARHGAP1 protein |
CTD |
PMID:23770345 |
|
NCBI chr 3:77,621,377...77,643,400
Ensembl chr 3:77,620,655...77,643,396
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|
G |
Arhgdia |
Rho GDP dissociation inhibitor alpha |
increases expression |
ISO |
butylidenephthalide results in increased expression of ARHGDIA protein |
CTD |
PMID:23770345 |
|
NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023
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|
G |
Atp5f1a |
ATP synthase F1 subunit alpha |
increases expression |
ISO |
butylidenephthalide results in increased expression of ATP5F1A protein |
CTD |
PMID:23770345 |
|
NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
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|
G |
Atp5f1b |
ATP synthase F1 subunit beta |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of ATP5F1B protein |
CTD |
PMID:23770345 |
|
NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
EXP ISO |
butylidenephthalide results in increased expression of BAX protein |
CTD |
PMID:16987298 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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|
G |
Bik |
BCL2-interacting killer |
increases expression |
ISO |
butylidenephthalide results in increased expression of BIK protein |
CTD |
PMID:23770345 |
|
NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296
|
|
G |
C1qbp |
complement C1q binding protein |
increases expression |
ISO |
butylidenephthalide results in increased expression of C1QBP protein |
CTD |
PMID:23770345 |
|
NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649
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|
G |
Calr |
calreticulin |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of CALR protein |
CTD |
PMID:23770345 |
|
NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
|
|
G |
Casp3 |
caspase 3 |
increases cleavage |
ISO EXP |
butylidenephthalide results in increased cleavage of CASP3 protein |
CTD |
PMID:16987298 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp8 |
caspase 8 |
increases cleavage |
ISO EXP |
butylidenephthalide results in increased cleavage of CASP8 protein |
CTD |
PMID:16987298 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
|
|
G |
Casp9 |
caspase 9 |
increases cleavage |
EXP ISO |
butylidenephthalide results in increased cleavage of CASP9 protein |
CTD |
PMID:16987298 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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|
G |
Ccnd1 |
cyclin D1 |
decreases expression |
EXP ISO |
butylidenephthalide results in decreased expression of CCND1 protein |
CTD |
PMID:16987298 PMID:23770345 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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|
G |
Ccne1 |
cyclin E1 |
decreases expression |
ISO EXP |
butylidenephthalide results in decreased expression of CCNE1 protein |
CTD |
PMID:16987298 |
|
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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|
G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
EXP ISO |
butylidenephthalide results in decreased expression of CDK2 protein |
CTD |
PMID:16987298 PMID:23770345 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
|
|
G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
EXP ISO |
butylidenephthalide results in decreased expression of CDK4 protein |
CTD |
PMID:16987298 |
|
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
|
|
G |
Cdk6 |
cyclin-dependent kinase 6 |
decreases expression |
EXP ISO |
butylidenephthalide results in decreased expression of CDK6 protein |
CTD |
PMID:16987298 |
|
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
decreases expression increases expression |
EXP ISO |
butylidenephthalide results in decreased expression of CDKN1A protein butylidenephthalide results in increased expression of CDKN1A protein |
CTD |
PMID:16987298 PMID:23770345 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
EXP |
butylidenephthalide results in increased expression of CDKN1B protein |
CTD |
PMID:16987298 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
|
|
G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
increases expression |
ISO |
butylidenephthalide results in increased expression of CDKN2A protein |
CTD |
PMID:16987298 PMID:23770345 |
|
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
|
|
G |
Cycs |
cytochrome c, somatic |
increases expression |
ISO |
butylidenephthalide results in increased expression of CYCS protein |
CTD |
PMID:23770345 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases expression |
ISO |
butylidenephthalide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] butylidenephthalide results in increased expression of CYP1A1 mRNA |
CTD |
PMID:29191726 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
|
|
G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
butylidenephthalide results in increased expression of DDIT3 protein |
CTD |
PMID:23770345 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
|
|
G |
Eef1a1 |
eukaryotic translation elongation factor 1 alpha 1 |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of EEF1A1 protein |
CTD |
PMID:23770345 |
|
NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839
|
|
G |
Eef1a2 |
eukaryotic translation elongation factor 1 alpha 2 |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of EEF1A2 protein |
CTD |
PMID:23770345 |
|
NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071
|
|
G |
Eef2 |
eukaryotic translation elongation factor 2 |
increases expression |
ISO |
butylidenephthalide results in increased expression of EEF2 protein |
CTD |
PMID:23770345 |
|
NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183
|
|
G |
Eif4a1 |
eukaryotic translation initiation factor 4A1 |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of EIF4A1 protein |
CTD |
PMID:23770345 |
|
NCBI chr10:54,384,345...54,389,855
Ensembl chr10:54,384,347...54,389,858
|
|
G |
Elavl1 |
ELAV like RNA binding protein 1 |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of ELAVL1 protein |
CTD |
PMID:23770345 |
|
NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784
|
|
G |
Eno1 |
enolase 1 |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of ENO1 protein |
CTD |
PMID:23770345 |
|
NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
|
|
G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
increases expression |
ISO |
butylidenephthalide results in increased expression of ERN1 protein |
CTD |
PMID:23770345 |
|
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
|
|
G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
butylidenephthalide results in increased expression of FAS protein |
CTD |
PMID:16987298 PMID:23770345 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
|
|
G |
Fus |
Fus RNA binding protein |
increases expression |
ISO |
butylidenephthalide results in increased expression of FUS protein |
CTD |
PMID:23770345 |
|
NCBI chr 1:182,576,479...182,590,417
Ensembl chr 1:182,576,545...182,590,414
|
|
G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
increases expression |
ISO |
butylidenephthalide results in increased expression of GOT1 protein |
CTD |
PMID:23770345 |
|
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
|
|
G |
Hnrnpa3 |
heterogeneous nuclear ribonucleoprotein A3 |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of HNRNPA3 protein |
CTD |
PMID:23770345 |
|
NCBI chr 3:60,578,574...60,588,755
Ensembl chr 3:60,578,673...60,588,306
|
|
G |
Hnrnpd |
heterogeneous nuclear ribonucleoprotein D |
increases expression |
ISO |
butylidenephthalide results in increased expression of HNRNPD protein |
CTD |
PMID:23770345 |
|
NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786
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|
G |
Hnrnpf |
heterogeneous nuclear ribonucleoprotein F |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of HNRNPF protein |
CTD |
PMID:23770345 |
|
NCBI chr 4:151,083,262...151,104,464
Ensembl chr 4:151,083,062...151,109,038
|
|
G |
Hsp90ab1 |
heat shock protein 90 alpha family class B member 1 |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of HSP90AB1 protein |
CTD |
PMID:23770345 |
|
NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
|
|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
ISO |
butylidenephthalide results in increased expression of HSPA5 protein |
CTD |
PMID:23770345 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
|
|
G |
Ldha |
lactate dehydrogenase A |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of LDHA protein |
CTD |
PMID:23770345 |
|
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
|
|
G |
Mif |
macrophage migration inhibitory factor |
increases expression |
ISO |
butylidenephthalide results in increased expression of MIF protein |
CTD |
PMID:23770345 |
|
NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
|
|
G |
Mki67 |
marker of proliferation Ki-67 |
decreases expression |
ISO EXP |
butylidenephthalide results in decreased expression of MKI67 protein |
CTD |
PMID:16987298 |
|
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
|
|
G |
Ncl |
nucleolin |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of NCL protein |
CTD |
PMID:23770345 |
|
NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136
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|
G |
Nme1 |
NME/NM23 nucleoside diphosphate kinase 1 |
increases expression |
ISO |
butylidenephthalide results in increased expression of NME1 protein |
CTD |
PMID:23770345 |
|
NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408
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|
G |
Pcna |
proliferating cell nuclear antigen |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of PCNA protein |
CTD |
PMID:23770345 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
|
|
G |
Pgk1 |
phosphoglycerate kinase 1 |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of PGK1 protein |
CTD |
PMID:23770345 |
|
NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418
|
|
G |
Phb1 |
prohibitin 1 |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of PHB1 protein |
CTD |
PMID:23770345 |
|
NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
|
|
G |
Ppp2r1a |
protein phosphatase 2 scaffold subunit A alpha |
increases expression |
ISO |
butylidenephthalide results in increased expression of PPP2R1A protein |
CTD |
PMID:23770345 |
|
NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129
|
|
G |
Prps1 |
phosphoribosyl pyrophosphate synthetase 1 |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of PRPS1 protein |
CTD |
PMID:23770345 |
|
NCBI chr X:104,132,139...104,154,191
Ensembl chr X:104,132,141...104,154,187
|
|
G |
Psma1 |
proteasome 20S subunit alpha 1 |
increases expression |
ISO |
butylidenephthalide results in increased expression of PSMA1 protein |
CTD |
PMID:23770345 |
|
NCBI chr 1:168,442,421...168,453,440
Ensembl chr 1:168,440,936...168,453,472
|
|
G |
Psmd11 |
proteasome 26S subunit, non-ATPase 11 |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of PSMD11 protein |
CTD |
PMID:23770345 |
|
NCBI chr10:65,433,853...65,479,774
Ensembl chr10:65,433,853...65,479,766
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|
G |
Rb1 |
RB transcriptional corepressor 1 |
decreases phosphorylation |
ISO EXP |
butylidenephthalide results in decreased phosphorylation of RB1 protein |
CTD |
PMID:16987298 |
|
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
|
|
G |
Rpsa |
ribosomal protein SA |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of RPSA protein |
CTD |
PMID:23770345 |
|
NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247
|
|
G |
Sf3b3 |
splicing factor 3b, subunit 3 |
increases expression |
ISO |
butylidenephthalide results in increased expression of SF3B3 protein |
CTD |
PMID:23770345 |
|
NCBI chr19:38,782,749...38,820,271
Ensembl chr19:38,783,040...38,820,245
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|
G |
Sfn |
stratifin |
increases expression |
ISO |
butylidenephthalide results in increased expression of SFN protein |
CTD |
PMID:23770345 |
|
NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314
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|
G |
Tp53 |
tumor protein p53 |
increases expression increases phosphorylation |
ISO |
butylidenephthalide results in increased expression of TP53 protein butylidenephthalide results in increased phosphorylation of TP53 protein |
CTD |
PMID:16987298 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
G |
Tpt1 |
tumor protein, translationally-controlled 1 |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of TPT1 protein |
CTD |
PMID:23770345 |
|
NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625
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|
G |
Tufm |
Tu translation elongation factor, mitochondrial |
increases expression |
ISO |
butylidenephthalide results in increased expression of TUFM protein |
CTD |
PMID:23770345 |
|
NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395
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|
G |
Was |
WASP actin nucleation promoting factor |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of WAS protein |
CTD |
PMID:23770345 |
|
NCBI chr X:14,405,105...14,413,850
Ensembl chr X:14,405,124...14,413,849
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|
G |
Ybx1 |
Y box binding protein 1 |
decreases expression |
ISO |
butylidenephthalide results in decreased expression of YBX1 protein |
CTD |
PMID:23770345 |
|
NCBI chr 5:132,882,137...132,898,885
Ensembl chr 5:132,882,145...132,898,862
|
|
|
G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
affects transport |
EXP |
ABCB4 protein affects the transport of Sulfobromophthalein |
CTD |
PMID:15304119 |
|
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
|
|
G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
affects export |
ISO |
ABCC2 protein affects the export of Sulfobromophthalein |
CTD |
PMID:16046661 |
|
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
|
|
G |
Cck |
cholecystokinin |
multiple interactions |
ISO |
Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of CCK protein modified form] |
CTD |
PMID:25106415 |
|
NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
|
|
G |
Gsta1 |
glutathione S-transferase alpha 1 |
multiple interactions affects binding |
ISO EXP |
Sulfobromophthalein binds to and affects the folding of and affects the activity of GSTA1 protein Sulfobromophthalein binds to [GSTA1 protein co-treated with GSTA1 protein]; Sulfobromophthalein binds to [GSTA3 protein co-treated with GSTA1 protein] Sulfobromophthalein binds to GSTA1 protein |
CTD |
PMID:3783048 PMID:9826190 PMID:15147239 |
|
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
|
|
G |
Gsta3 |
glutathione S-transferase alpha 3 |
multiple interactions decreases activity |
EXP |
Sulfobromophthalein binds to [GSTA3 protein co-treated with GSTA1 protein] Sulfobromophthalein results in decreased activity of GSTA3 protein |
CTD |
PMID:3783048 PMID:8968379 |
|
NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
|
|
G |
Gstm2 |
glutathione S-transferase mu 2 |
decreases activity |
EXP |
Sulfobromophthalein results in decreased activity of GSTM2 protein |
CTD |
PMID:8968379 |
|
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
|
|
G |
Hgf |
hepatocyte growth factor |
multiple interactions |
EXP |
Sulfobromophthalein inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide] |
CTD |
PMID:18031729 |
|
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
|
|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
Sulfobromophthalein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] |
CTD |
PMID:11907163 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
|
|
G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
Sulfobromophthalein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] |
CTD |
PMID:11907163 |
|
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
|
|
G |
Keap1 |
Kelch-like ECH-associated protein 1 |
decreases glutathionylation decreases transport |
ISO |
KEAP1 protein results in decreased glutathionylation of Sulfobromophthalein KEAP1 protein results in decreased transport of Sulfobromophthalein |
CTD |
PMID:19246623 |
|
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
affects abundance increases transport increases glutathionylation |
ISO |
NFE2L2 protein affects the abundance of Sulfobromophthalein NFE2L2 protein results in increased transport of Sulfobromophthalein NFE2L2 protein results in increased glutathionylation of Sulfobromophthalein |
CTD |
PMID:19246623 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Slc10a1 |
solute carrier family 10 member 1 |
multiple interactions |
ISO |
Sulfobromophthalein inhibits the reaction [SLC10A1 protein results in increased uptake of Taurocholic Acid] |
CTD |
PMID:25106415 |
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NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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Slc16a2 |
solute carrier family 16 member 2 |
multiple interactions |
ISO |
Sulfobromophthalein inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine] |
CTD |
PMID:28119167 |
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NCBI chr X:68,725,365...68,848,572
Ensembl chr X:68,723,261...68,848,771
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Slc19a1 |
solute carrier family 19 member 1 |
multiple interactions decreases activity |
EXP |
Sulfobromophthalein inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate] Sulfobromophthalein results in decreased activity of SLC19A1 protein |
CTD |
PMID:14612385 |
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NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972
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Slc22a25 |
solute carrier family 22, member 25 |
multiple interactions |
EXP |
Sulfobromophthalein inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate] |
CTD |
PMID:16079298 |
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NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
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Slc22a6 |
solute carrier family 22 member 6 |
multiple interactions |
ISO |
Sulfobromophthalein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] |
CTD |
PMID:11602689 |
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NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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Slc22a7 |
solute carrier family 22 member 7 |
multiple interactions |
ISO |
Sulfobromophthalein inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates] |
CTD |
PMID:12065749 |
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NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
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Slc22a8 |
solute carrier family 22 member 8 |
multiple interactions |
EXP |
Sulfobromophthalein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate] |
CTD |
PMID:10224140 |
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NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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Slc46a1 |
solute carrier family 46 member 1 |
multiple interactions decreases activity |
ISO EXP |
Sulfobromophthalein inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid] Sulfobromophthalein results in decreased activity of SLC46A1 protein |
CTD |
PMID:17475902 PMID:18174275 |
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NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848
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Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
multiple interactions |
ISO |
Sulfobromophthalein inhibits the reaction [SLCO1A2 protein results in increased uptake of Quercetin] |
CTD |
PMID:24947867 |
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NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
affects import increases import increases response to substance increases uptake multiple interactions |
ISO |
SLCO1B3 protein affects the import of Sulfobromophthalein SLCO1B3 protein results in increased import of Sulfobromophthalein SLCO1B3 protein results in increased susceptibility to Sulfobromophthalein SLCO1B3 protein results in increased uptake of Sulfobromophthalein Apigenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Budesonide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Clarithromycin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Cyclosporine inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; glimepiride affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; kaempferol inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; naringenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; naringin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Nateglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Pioglitazone affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Pravastatin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Quercetin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Rutin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased import of cyanoginosin LR]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of (5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of CCK protein modified form] |
CTD |
PMID:16046661 PMID:17369605 PMID:20171238 PMID:21430235 PMID:21661758 PMID:22394605 PMID:23121773 PMID:25106415 PMID:26134461 More...
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NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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Slco2b1 |
solute carrier organic anion transporter family, member 2b1 |
decreases activity increases uptake affects import multiple interactions |
ISO |
Sulfobromophthalein results in decreased activity of SLCO2B1 protein SLCO2B1 protein results in increased uptake of Sulfobromophthalein SLCO2B1 protein affects the import of Sulfobromophthalein Budesonide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Cyclosporine inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; glimepiride inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Nateglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Pioglitazone affects the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Pravastatin inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Rifampin inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased import of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin] |
CTD |
PMID:16046661 PMID:21430235 PMID:23121773 PMID:25106415 PMID:27450509 PMID:31364238 More...
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NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
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Akr1c1 |
aldo-keto reductase family 1, member C1 |
decreases activity multiple interactions |
ISO |
Phenolphthalein results in decreased activity of AKR1C1 protein Phenolphthalein inhibits the reaction [AKR1C1 protein affects the susceptibility to Oxaliplatin] |
CTD |
PMID:12604236 PMID:23933386 |
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NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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Akr1c2 |
aldo-keto reductase family 1, member C2 |
decreases activity |
ISO |
Phenolphthalein results in decreased activity of AKR1C2 protein |
CTD |
PMID:12604236 |
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NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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Akr1c3 |
aldo-keto reductase family 1, member C3 |
decreases activity multiple interactions |
ISO |
Phenolphthalein results in decreased activity of AKR1C3 protein Phenolphthalein inhibits the reaction [AKR1C3 protein affects the susceptibility to oxaliplatin] |
CTD |
PMID:12604236 PMID:23933386 |
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NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Esr1 |
estrogen receptor 1 |
affects binding multiple interactions increases activity |
ISO |
Phenolphthalein binds to ESR1 protein Phenolphthalein binds to and results in decreased activity of ESR1 protein Phenolphthalein results in increased activity of ESR1 protein |
CTD |
PMID:12598185 PMID:25012808 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
Phenolphthalein inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] |
CTD |
PMID:23769903 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
Phenolphthalein binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:20869355 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions |
ISO |
Phenolphthalein binds to and results in decreased activity of NR1I3 protein alternative form; Phenolphthalein binds to and results in increased activity of NR1I3 protein alternative form |
CTD |
PMID:20869355 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Por |
cytochrome p450 oxidoreductase |
multiple interactions |
ISO |
Phenolphthalein inhibits the reaction [POR protein affects the reaction [Benzo(a)pyrene results in increased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]] |
CTD |
PMID:28111842 |
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NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Shbg |
sex hormone binding globulin |
affects binding |
ISO |
Phenolphthalein binds to SHBG protein |
CTD |
PMID:25349334 |
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NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
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Tyms |
thymidylate synthetase |
decreases activity |
ISO |
Phenolphthalein results in decreased activity of TYMS protein |
CTD |
PMID:21696158 |
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NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
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