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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-benzofuran-1(3H)-one
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Accession:CHEBI:38085 term browser browse the term
Definition:A gamma-lactone that is 1,3-dihydro-2-benzofuran in which the hydrogens at position 1 are replaced by an oxo group.
Synonyms:related_synonym: 1(3H)-isobenzofuranone;   1-Phthalanone;   2-Hydroxymethylbenzoic acid, gamma-lactone;   3-oxo-1,3-dihydro-isobenzofuran;   Formula=C8H6O2;   InChI=1S/C8H6O2/c9-8-7-4-2-1-3-6(7)5-10-8/h1-4H,5H2;   InChIKey=WNZQDUSMALZDQF-UHFFFAOYSA-N;   Phthalolactone;   SMILES=O=C1OCc2ccccc12;   isobenzofuranone;   phthalide
 xref: CAS:87-41-2;   HMDB:HMDB0032469;   PMID:23462848;   Reaxys:114632;   Wikipedia:Phthalide



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(Z)-3-butylidenephthalide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO [butylidenephthalide co-treated with ligustilide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; butylidenephthalide inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:29191726 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression EXP
ISO
butylidenephthalide results in increased expression of AIFM1 protein CTD PMID:16987298 PMID:23770345 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Anxa5 annexin A5 decreases expression ISO butylidenephthalide results in decreased expression of ANXA5 protein CTD PMID:23770345 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
JBrowse link
G Arhgap1 Rho GTPase activating protein 1 increases expression ISO butylidenephthalide results in increased expression of ARHGAP1 protein CTD PMID:23770345 NCBI chr 3:77,621,377...77,643,400
Ensembl chr 3:77,620,655...77,643,396
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression ISO butylidenephthalide results in increased expression of ARHGDIA protein CTD PMID:23770345 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression ISO butylidenephthalide results in increased expression of ATP5F1A protein CTD PMID:23770345 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression ISO butylidenephthalide results in decreased expression of ATP5F1B protein CTD PMID:23770345 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP
ISO
butylidenephthalide results in increased expression of BAX protein CTD PMID:16987298 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bik BCL2-interacting killer increases expression ISO butylidenephthalide results in increased expression of BIK protein CTD PMID:23770345 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296
JBrowse link
G C1qbp complement C1q binding protein increases expression ISO butylidenephthalide results in increased expression of C1QBP protein CTD PMID:23770345 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649
JBrowse link
G Calr calreticulin decreases expression ISO butylidenephthalide results in decreased expression of CALR protein CTD PMID:23770345 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Casp3 caspase 3 increases cleavage ISO
EXP
butylidenephthalide results in increased cleavage of CASP3 protein CTD PMID:16987298 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage ISO
EXP
butylidenephthalide results in increased cleavage of CASP8 protein CTD PMID:16987298 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases cleavage EXP
ISO
butylidenephthalide results in increased cleavage of CASP9 protein CTD PMID:16987298 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP
ISO
butylidenephthalide results in decreased expression of CCND1 protein CTD PMID:16987298 PMID:23770345 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO
EXP
butylidenephthalide results in decreased expression of CCNE1 protein CTD PMID:16987298 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression EXP
ISO
butylidenephthalide results in decreased expression of CDK2 protein CTD PMID:16987298 PMID:23770345 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression EXP
ISO
butylidenephthalide results in decreased expression of CDK4 protein CTD PMID:16987298 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression EXP
ISO
butylidenephthalide results in decreased expression of CDK6 protein CTD PMID:16987298 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
increases expression
EXP
ISO
butylidenephthalide results in decreased expression of CDKN1A protein
butylidenephthalide results in increased expression of CDKN1A protein
CTD PMID:16987298 PMID:23770345 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP butylidenephthalide results in increased expression of CDKN1B protein CTD PMID:16987298 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO butylidenephthalide results in increased expression of CDKN2A protein CTD PMID:16987298 PMID:23770345 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO butylidenephthalide results in increased expression of CYCS protein CTD PMID:23770345 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO butylidenephthalide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
butylidenephthalide results in increased expression of CYP1A1 mRNA
CTD PMID:29191726 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO butylidenephthalide results in increased expression of DDIT3 protein CTD PMID:23770345 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 decreases expression ISO butylidenephthalide results in decreased expression of EEF1A1 protein CTD PMID:23770345 NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839
JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 decreases expression ISO butylidenephthalide results in decreased expression of EEF1A2 protein CTD PMID:23770345 NCBI chr 3:168,265,893...168,275,071 JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases expression ISO butylidenephthalide results in increased expression of EEF2 protein CTD PMID:23770345 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183
JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 decreases expression ISO butylidenephthalide results in decreased expression of EIF4A1 protein CTD PMID:23770345 NCBI chr10:54,384,345...54,389,853
Ensembl chr10:54,384,347...54,389,858
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 decreases expression ISO butylidenephthalide results in decreased expression of ELAVL1 protein CTD PMID:23770345 NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784
JBrowse link
G Eno1 enolase 1 decreases expression ISO butylidenephthalide results in decreased expression of ENO1 protein CTD PMID:23770345 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO butylidenephthalide results in increased expression of ERN1 protein CTD PMID:23770345 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO butylidenephthalide results in increased expression of FAS protein CTD PMID:16987298 PMID:23770345 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fus FUS RNA binding protein increases expression ISO butylidenephthalide results in increased expression of FUS protein CTD PMID:23770345 NCBI chr 1:182,576,479...182,590,417
Ensembl chr 1:182,576,545...182,590,414
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression ISO butylidenephthalide results in increased expression of GOT1 protein CTD PMID:23770345 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 decreases expression ISO butylidenephthalide results in decreased expression of HNRNPA3 protein CTD PMID:23770345 NCBI chr 3:60,578,574...60,588,755
Ensembl chr 3:60,578,673...60,588,306
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D increases expression ISO butylidenephthalide results in increased expression of HNRNPD protein CTD PMID:23770345 NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786
JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F decreases expression ISO butylidenephthalide results in decreased expression of HNRNPF protein CTD PMID:23770345 NCBI chr 4:151,083,262...151,104,464
Ensembl chr 4:151,083,062...151,109,038
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression ISO butylidenephthalide results in decreased expression of HSP90AB1 protein CTD PMID:23770345 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO butylidenephthalide results in increased expression of HSPA5 protein CTD PMID:23770345 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO butylidenephthalide results in decreased expression of LDHA protein CTD PMID:23770345 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G Mif macrophage migration inhibitory factor increases expression ISO butylidenephthalide results in increased expression of MIF protein CTD PMID:23770345 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO
EXP
butylidenephthalide results in decreased expression of MKI67 protein CTD PMID:16987298 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Ncl nucleolin decreases expression ISO butylidenephthalide results in decreased expression of NCL protein CTD PMID:23770345 NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136
JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 increases expression ISO butylidenephthalide results in increased expression of NME1 protein CTD PMID:23770345 NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO butylidenephthalide results in decreased expression of PCNA protein CTD PMID:23770345 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pgk1 phosphoglycerate kinase 1 decreases expression ISO butylidenephthalide results in decreased expression of PGK1 protein CTD PMID:23770345 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418
JBrowse link
G Phb1 prohibitin 1 decreases expression ISO butylidenephthalide results in decreased expression of PHB protein CTD PMID:23770345 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha increases expression ISO butylidenephthalide results in increased expression of PPP2R1A protein CTD PMID:23770345 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129
JBrowse link
G Prps1 phosphoribosyl pyrophosphate synthetase 1 decreases expression ISO butylidenephthalide results in decreased expression of PRPS1 protein CTD PMID:23770345 NCBI chr  X:104,132,139...104,154,191
Ensembl chr  X:104,132,141...104,154,187
JBrowse link
G Psma1 proteasome 20S subunit alpha 1 increases expression ISO butylidenephthalide results in increased expression of PSMA1 protein CTD PMID:23770345 NCBI chr 1:168,442,421...168,453,440
Ensembl chr 1:168,440,936...168,453,472
JBrowse link
G Psmd11 proteasome 26S subunit, non-ATPase 11 decreases expression ISO butylidenephthalide results in decreased expression of PSMD11 protein CTD PMID:23770345 NCBI chr10:65,433,853...65,479,774
Ensembl chr10:65,433,853...65,479,766
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO
EXP
butylidenephthalide results in decreased phosphorylation of RB1 protein CTD PMID:16987298 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rpsa ribosomal protein SA decreases expression ISO butylidenephthalide results in decreased expression of RPSA protein CTD PMID:23770345 NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247
JBrowse link
G Sf3b3 splicing factor 3b, subunit 3 increases expression ISO butylidenephthalide results in increased expression of SF3B3 protein CTD PMID:23770345 NCBI chr19:38,782,749...38,820,271
Ensembl chr19:38,783,040...38,820,245
JBrowse link
G Sfn stratifin increases expression ISO butylidenephthalide results in increased expression of SFN protein CTD PMID:23770345 Ensembl chr 5:145,826,201...145,831,314 JBrowse link
G Tp53 tumor protein p53 increases expression
increases phosphorylation
ISO butylidenephthalide results in increased expression of TP53 protein
butylidenephthalide results in increased phosphorylation of TP53 protein
CTD PMID:16987298 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 decreases expression ISO butylidenephthalide results in decreased expression of TPT1 protein CTD PMID:23770345 NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625
JBrowse link
G Tufm Tu translation elongation factor, mitochondrial increases expression ISO butylidenephthalide results in increased expression of TUFM protein CTD PMID:23770345 NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395
JBrowse link
G Was WASP actin nucleation promoting factor decreases expression ISO butylidenephthalide results in decreased expression of WAS protein CTD PMID:23770345 NCBI chr  X:14,405,096...14,413,850
Ensembl chr  X:14,405,124...14,413,849
JBrowse link
G Ybx1 Y box binding protein 1 decreases expression ISO butylidenephthalide results in decreased expression of YBX1 protein CTD PMID:23770345 NCBI chr 5:132,882,137...132,899,108
Ensembl chr 5:132,882,145...132,898,862
JBrowse link
bromosulfophthalein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 affects transport EXP ABCB4 protein affects the transport of Sulfobromophthalein CTD PMID:15304119 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export ISO ABCC2 protein affects the export of Sulfobromophthalein CTD PMID:16046661 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Cck cholecystokinin multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of CCK protein modified form] CTD PMID:25106415 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions
affects binding
ISO
EXP
Sulfobromophthalein binds to and affects the folding of and affects the activity of GSTA1 protein
Sulfobromophthalein binds to [GSTA1 protein co-treated with GSTA1 protein]; Sulfobromophthalein binds to [GSTA3 protein co-treated with GSTA1 protein]
Sulfobromophthalein binds to GSTA1 protein
CTD PMID:3783048 PMID:9826190 PMID:15147239 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 multiple interactions
decreases activity
EXP Sulfobromophthalein binds to [GSTA3 protein co-treated with GSTA1 protein]
Sulfobromophthalein results in decreased activity of GSTA3 protein
CTD PMID:3783048 PMID:8968379 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases activity EXP Sulfobromophthalein results in decreased activity of GSTM2 protein CTD PMID:8968379 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Hgf hepatocyte growth factor multiple interactions EXP Sulfobromophthalein inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:18031729 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Ifng interferon gamma multiple interactions ISO Sulfobromophthalein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Sulfobromophthalein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases glutathionylation
decreases transport
ISO KEAP1 protein results in decreased glutathionylation of Sulfobromophthalein
KEAP1 protein results in decreased transport of Sulfobromophthalein
CTD PMID:19246623 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects abundance
increases transport
increases glutathionylation
ISO NFE2L2 protein affects the abundance of Sulfobromophthalein
NFE2L2 protein results in increased transport of Sulfobromophthalein
NFE2L2 protein results in increased glutathionylation of Sulfobromophthalein
CTD PMID:19246623 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC10A1 protein results in increased uptake of Taurocholic Acid] CTD PMID:25106415 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc16a2 solute carrier family 16 member 2 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine] CTD PMID:28119167 NCBI chr  X:68,725,365...68,848,572
Ensembl chr  X:68,723,261...68,848,771
JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions
decreases activity
EXP Sulfobromophthalein inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]
Sulfobromophthalein results in decreased activity of SLC19A1 protein
CTD PMID:14612385 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:11602689 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates] CTD PMID:12065749 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP Sulfobromophthalein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate] CTD PMID:10224140 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc46a1 solute carrier family 46 member 1 multiple interactions
decreases activity
ISO
EXP
Sulfobromophthalein inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]
Sulfobromophthalein results in decreased activity of SLC46A1 protein
CTD PMID:17475902 PMID:18174275 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLCO1A2 protein results in increased uptake of Quercetin] CTD PMID:24947867 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 affects import
increases import
increases response to substance
increases uptake
multiple interactions
ISO SLCO1B3 protein affects the import of Sulfobromophthalein
SLCO1B3 protein results in increased import of Sulfobromophthalein
SLCO1B3 protein results in increased susceptibility to Sulfobromophthalein
SLCO1B3 protein results in increased uptake of Sulfobromophthalein
Apigenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Budesonide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Clarithromycin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Cyclosporine inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; glimepiride affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; kaempferol inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; naringenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; naringin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Nateglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Pioglitazone affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Pravastatin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Quercetin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Rutin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased import of cyanoginosin LR]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of (5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of CCK protein modified form]
CTD PMID:16046661 PMID:17369605 PMID:20171238 PMID:21430235 PMID:21661758 More... NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 affects import
decreases activity
multiple interactions
increases uptake
ISO SLCO2B1 protein affects the import of Sulfobromophthalein
Sulfobromophthalein results in decreased activity of SLCO2B1 protein
Budesonide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Cyclosporine inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; glimepiride inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Nateglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Pioglitazone affects the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Pravastatin inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Rifampin inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased import of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]
CTD PMID:16046661 PMID:21430235 PMID:23121773 PMID:25106415 PMID:27450509 More... NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
JBrowse link
phenolphthalein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity
multiple interactions
ISO Phenolphthalein results in decreased activity of AKR1C1 protein
Phenolphthalein inhibits the reaction [AKR1C1 protein affects the susceptibility to Oxaliplatin]
CTD PMID:12604236 PMID:23933386 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Phenolphthalein results in decreased activity of AKR1C2 protein CTD PMID:12604236 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity
multiple interactions
ISO Phenolphthalein results in decreased activity of AKR1C3 protein
Phenolphthalein inhibits the reaction [AKR1C3 protein affects the susceptibility to oxaliplatin]
CTD PMID:12604236 PMID:23933386 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions
increases activity
ISO Phenolphthalein binds to ESR1 protein
Phenolphthalein binds to and results in decreased activity of ESR1 protein
Phenolphthalein results in increased activity of ESR1 protein
CTD PMID:12598185 PMID:25012808 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Phenolphthalein inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Phenolphthalein binds to and results in increased activity of NR1I2 protein CTD PMID:20869355 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Phenolphthalein binds to and results in decreased activity of NR1I3 protein alternative form; Phenolphthalein binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO Phenolphthalein inhibits the reaction [POR protein affects the reaction [Benzo(a)pyrene results in increased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]] CTD PMID:28111842 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Phenolphthalein binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
JBrowse link
G Tyms thymidylate synthetase decreases activity ISO Phenolphthalein results in decreased activity of TYMS protein CTD PMID:21696158 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    chemical entity 19795
      group 19717
        inorganic group 19241
          oxo group 18646
            organic oxo compound 18646
              carbonyl compound 18646
                carboxylic ester 15881
                  lactone 11255
                    gamma-lactone 6752
                      2-benzofuran-1(3H)-one 92
                        (Z)-3-butylidene-7-hydroxyphthalide 0
                        (Z)-3-butylidenephthalide 61
                        4,5,6,7-tetrachloro-2-benzofuran-1(3H)-one 0
                        4-farnesyl-3,5-dihydroxy-6-methylphthalide 0
                        bromosulfophthalein 21
                        bromosulfophthalein sodium 0
                        phenolphthalein 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic group 18713
                              organic divalent group 18697
                                organodiyl group 18697
                                  carbonyl group 18646
                                    carbonyl compound 18646
                                      carboxylic ester 15881
                                        lactone 11255
                                          gamma-lactone 6752
                                            2-benzofuran-1(3H)-one 92
                                              (Z)-3-butylidene-7-hydroxyphthalide 0
                                              (Z)-3-butylidenephthalide 61
                                              4,5,6,7-tetrachloro-2-benzofuran-1(3H)-one 0
                                              4-farnesyl-3,5-dihydroxy-6-methylphthalide 0
                                              bromosulfophthalein 21
                                              bromosulfophthalein sodium 0
                                              phenolphthalein 10
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