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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulfoximide
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Accession:CHEBI:38084 term browser browse the term
Definition:Compounds having the structure RS(=O)=NR.
Synonyms:related_synonym: sulfoximides;   sulfoximines



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methionine sulfoximine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Methionine Sulfoximine results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Methionine Sulfoximine results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Methionine Sulfoximine results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Methionine Sulfoximine results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Methionine Sulfoximine results in increased expression of GFAP protein CTD PMID:2565645 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Glul glutamate-ammonia ligase decreases activity
multiple interactions
EXP Methionine Sulfoximine results in decreased activity of GLUL protein
[Methionine Sulfoximine results in decreased activity of GLUL protein] which results in increased abundance of Ammonia
CTD PMID:19619585 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Methionine Sulfoximine results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Methionine Sulfoximine results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
S-butyl-DL-homocysteine (S,R)-sulfoximine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects localization
multiple interactions
ISO Buthionine Sulfoximine affects the localization of ABCC1 protein mutant form
[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [ABCC1 results in decreased susceptibility to arsenite]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [ABCC1 results in decreased susceptibility to monomethylarsonous acid analog]; Buthionine Sulfoximine analog inhibits the reaction [Acetylcysteine promotes the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin]]; Buthionine Sulfoximine inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; Buthionine Sulfoximine inhibits the reaction [ABCC1 results in decreased susceptibility to arsenite]; Buthionine Sulfoximine inhibits the reaction [ABCC1 results in decreased susceptibility to methylarsine analog]
CTD PMID:15180633 PMID:15473893 PMID:15581632 PMID:21918036 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Acin1 apoptotic chromatin condensation inducer 1 increases expression EXP Buthionine Sulfoximine results in increased expression of ACIN1 protein CTD PMID:23736079 NCBI chr15:28,102,112...28,147,001
Ensembl chr15:28,102,112...28,147,001
JBrowse link
G Aco2 aconitase 2 decreases activity ISO Buthionine Sulfoximine results in decreased activity of ACO2 protein CTD PMID:18552690 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
JBrowse link
G Actb actin, beta decreases expression ISO Buthionine Sulfoximine results in decreased expression of ACTB mRNA CTD PMID:15878706 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Add3 adducin 3 increases expression ISO Buthionine Sulfoximine results in increased expression of ADD3 mRNA CTD PMID:15878706 NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) multiple interactions EXP Buthionine Sulfoximine promotes the reaction [Ethanol results in increased expression of ADH1 mRNA] CTD PMID:20705415 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 increases expression ISO Buthionine Sulfoximine results in increased expression of AIMP1 mRNA CTD PMID:15878706 NCBI chr 2:221,151,907...221,175,458
Ensembl chr 2:221,151,904...221,175,728
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Buthionine Sulfoximine promotes the reaction [Cadmium results in increased phosphorylation of AKT1 protein] CTD PMID:24449419 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alad aminolevulinate dehydratase decreases activity EXP Buthionine Sulfoximine results in decreased activity of ALAD protein CTD PMID:21620807 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [1,2,4-trichlorobenzene results in increased activity of ALAS1 protein] CTD PMID:11996131 NCBI chr 8:106,876,514...106,889,852
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Alb albumin multiple interactions EXP [Aflatoxin B1 co-treated with Buthionine Sulfoximine] results in increased expression of ALB mRNA CTD PMID:23288050 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Buthionine Sulfoximine results in increased expression of ALDOA mRNA; Buthionine Sulfoximine results in increased expression of ALDOA protein CTD PMID:11841787 PMID:23736079 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor multiple interactions EXP [Aflatoxin B1 co-treated with Buthionine Sulfoximine] results in increased expression of AMBP mRNA CTD PMID:23288050 NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression EXP Buthionine Sulfoximine results in increased expression of APEX1 protein CTD PMID:23736079 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Apoh apolipoprotein H multiple interactions EXP [Aflatoxin B1 co-treated with Buthionine Sulfoximine] results in increased expression of APOH mRNA CTD PMID:23288050 NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator decreases expression ISO Buthionine Sulfoximine results in decreased expression of ARNT protein CTD PMID:16880289 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 decreases expression ISO Buthionine Sulfoximine results in decreased expression of ATP2A2 protein CTD PMID:18552690 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta increases expression ISO Buthionine Sulfoximine results in increased expression of ATP5B mRNA CTD PMID:15878706 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
JBrowse link
G Atxn1 ataxin 1 affects localization
multiple interactions
ISO Buthionine Sulfoximine affects the localization of ATXN1 protein mutant form
Buthionine Sulfoximine promotes the reaction [Hydrogen Peroxide affects the localization of ATXN1 protein mutant form]; Buthionine Sulfoximine promotes the reaction [tert-Butylhydroperoxide affects the localization of ATXN1 protein mutant form]
CTD PMID:12893416 NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360
JBrowse link
G Axl Axl receptor tyrosine kinase increases expression ISO Buthionine Sulfoximine results in increased expression of AXL mRNA CTD PMID:15878706 NCBI chr 1:81,265,656...81,296,278
Ensembl chr 1:81,265,088...81,296,265
JBrowse link
G Azin1 antizyme inhibitor 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of AZIN1 mRNA CTD PMID:15878706 NCBI chr 7:69,654,773...69,681,578
Ensembl chr 7:69,654,663...69,681,578
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Buthionine Sulfoximine results in increased expression of BAX protein
[Cadmium Chloride co-treated with Buthionine Sulfoximine] results in decreased expression of BAX protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Buthionine Sulfoximine] results in decreased expression of BAX protein]
CTD PMID:11341981 PMID:18552690 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
Buthionine Sulfoximine results in decreased expression of BCL2 mRNA; Buthionine Sulfoximine results in decreased expression of BCL2 protein
Buthionine Sulfoximine promotes the reaction [cyanoginosin LR results in decreased expression of BCL2 protein]
[Cadmium Chloride co-treated with Buthionine Sulfoximine] results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Buthionine Sulfoximine] results in increased expression of BCL2 protein]
Sodium Selenite promotes the reaction [Buthionine Sulfoximine results in decreased expression of BCL2 mRNA]
CTD PMID:11341981 PMID:17989939 PMID:18552690 PMID:25410294 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bmp1 bone morphogenetic protein 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of BMP1 mRNA CTD PMID:15878706 NCBI chr15:45,551,603...45,595,862
Ensembl chr15:45,551,603...45,595,776
JBrowse link
G Calr calreticulin increases expression EXP Buthionine Sulfoximine results in increased expression of CALR protein CTD PMID:23736079 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
ISO
EXP
4-amylcinnamoylanthranilic acid inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP3 protein]; Sodium Selenite promotes the reaction [Buthionine Sulfoximine results in increased expression of CASP3 mRNA]
[O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate co-treated with Buthionine Sulfoximine] results in increased cleavage of CASP3 protein; Buthionine Sulfoximine promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased activity of CASP3 protein]
[Buthionine Sulfoximine co-treated with Arsenic Trioxide] results in increased activity of CASP3 protein; [monomethylarsonic acid co-treated with Buthionine Sulfoximine] results in increased activity of CASP3 protein; Buthionine Sulfoximine inhibits the reaction [Cacodylic Acid results in increased activity of CASP3 protein]; Buthionine Sulfoximine promotes the reaction [Vitamin K 3 results in increased activity of CASP3 protein]
CTD PMID:10673743 PMID:15276415 PMID:15963344 PMID:16310883 PMID:17200146 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp4 caspase 4 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased activity of CASP4 protein] CTD PMID:25341683 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate affects the cleavage of CASP7 protein] CTD PMID:20962031 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Buthionine Sulfoximine co-treated with arsenic trioxide] results in increased cleavage of CASP8 protein; pyrazolanthrone inhibits the reaction [[Buthionine Sulfoximine co-treated with arsenic trioxide] results in increased cleavage of CASP8 protein] CTD PMID:17145888 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO 4-amylcinnamoylanthranilic acid inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP9 protein]; Glutathione inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP9 protein] CTD PMID:33309544 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP
ISO
Buthionine Sulfoximine results in decreased activity of CAT protein
Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of CAT protein]; CAT inhibits the reaction [Buthionine Sulfoximine results in decreased abundance of Glutathione]; CAT inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]; CAT inhibits the reaction [Buthionine Sulfoximine results in increased uptake of malondialdehyde-low density lipoprotein, human]; CD36 mRNA promotes the reaction [CAT inhibits the reaction [Buthionine Sulfoximine results in increased uptake of malondialdehyde-low density lipoprotein, human]]; Plant Extracts inhibits the reaction [Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of CAT protein]]
CTD PMID:21620807 PMID:21772021 PMID:26187465 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of CCL11 mRNA CTD PMID:22407903 PMID:27421576 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
[Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of CCL2 mRNA
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CCL2 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CCL2 mRNA]
CTD PMID:22407903 PMID:26177832 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [TNF protein results in increased expression of CCL5 protein]; SB 203580 inhibits the reaction [Buthionine Sulfoximine promotes the reaction [TNF protein results in increased expression of CCL5 protein]] CTD PMID:11167962 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of CCND1 protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein] CTD PMID:17602960 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd163 CD163 molecule multiple interactions EXP [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD163 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD163 mRNA] CTD PMID:26177832 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions
ISO Buthionine Sulfoximine results in increased expression of CD36 protein
[pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of CD36 mRNA; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]; CAT inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]; CD36 mRNA promotes the reaction [Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased uptake of malondialdehyde-low density lipoprotein, human]]; CD36 mRNA promotes the reaction [Buthionine Sulfoximine results in increased uptake of malondialdehyde-low density lipoprotein, human]; CD36 mRNA promotes the reaction [CAT inhibits the reaction [Buthionine Sulfoximine results in increased uptake of malondialdehyde-low density lipoprotein, human]]; PPARG mRNA promotes the reaction [Tamoxifen inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]]; Tamoxifen inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]
CTD PMID:26187465 PMID:27358406 PMID:28263783 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cd59 CD59 molecule increases mutagenesis ISO Buthionine Sulfoximine results in increased mutagenesis of CD59 gene CTD PMID:15033018 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
JBrowse link
G Cd68 Cd68 molecule multiple interactions EXP [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD68 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD68 mRNA] CTD PMID:26177832 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
JBrowse link
G Cd86 CD86 molecule increases expression ISO Buthionine Sulfoximine results in increased expression of CD86 protein CTD PMID:20457211 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of CDKN1A protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1A protein] CTD PMID:17602960 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of CDKN1B protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1B protein] CTD PMID:17602960 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [potassium chromate(VI) results in increased expression of CHEK2 protein modified form] CTD PMID:25977998 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Cherp calcium homeostasis endoplasmic reticulum protein increases expression EXP Buthionine Sulfoximine results in increased expression of CHERP protein CTD PMID:23736079 NCBI chr16:17,367,455...17,380,507
Ensembl chr16:17,367,455...17,380,507
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of COL1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of COL1A1 protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 protein] CTD PMID:17602960 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO Buthionine Sulfoximine promotes the reaction [CYP2E1 protein results in increased expression of COL1A2 mRNA] CTD PMID:10498651 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Col5a3 collagen type V alpha 3 chain decreases expression ISO Buthionine Sulfoximine results in decreased expression of COL5A3 mRNA CTD PMID:15878706 NCBI chr 8:19,304,564...19,349,809
Ensembl chr 8:19,304,571...19,349,853
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 increases expression ISO Buthionine Sulfoximine results in increased expression of COX4I1 mRNA CTD PMID:15878706 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921
JBrowse link
G Cse1l chromosome segregation 1 like increases expression EXP Buthionine Sulfoximine results in increased expression of CSE1L protein CTD PMID:23736079 NCBI chr 3:155,641,104...155,678,866
Ensembl chr 3:155,641,166...155,678,865
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CXCL1 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CXCL1 mRNA] CTD PMID:26177832 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Buthionine Sulfoximine results in decreased expression of CXCL12 mRNA CTD PMID:15878706 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO
EXP
[Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA; [pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA; Alprostadil inhibits the reaction [[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA]
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CXCL2 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CXCL2 mRNA]
CTD PMID:23986454 PMID:26177832 PMID:27421576 PMID:28263783 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Tobacco Smoke Pollution results in increased secretion of and results in increased expression of CXCL1 protein] CTD PMID:26149495 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Buthionine Sulfoximine results in decreased expression of CXCR4 mRNA CTD PMID:15878706 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases activity
ISO
EXP
Buthionine Sulfoximine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Buthionine Sulfoximine inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Buthionine Sulfoximine promotes the reaction [sodium arsenite inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]; Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of CYP1A1 mRNA]
Buthionine Sulfoximine results in decreased activity of CYP1A1 protein
Buthionine Sulfoximine results in increased activity of CYP1A1 protein
[Buthionine Sulfoximine co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; [Buthionine Sulfoximine co-treated with Cadmium Chloride] results in increased expression of CYP1A1 mRNA; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of CYP1A1 mRNA; Buthionine Sulfoximine inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Buthionine Sulfoximine promotes the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Buthionine Sulfoximine promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]]; Buthionine Sulfoximine promotes the reaction [chromium trioxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]]; Buthionine Sulfoximine promotes the reaction [chromium trioxide results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; Buthionine Sulfoximine promotes the reaction [Lead inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; Buthionine Sulfoximine promotes the reaction [Lead results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; Buthionine Sulfoximine promotes the reaction [sodium arsenite promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]]; Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Buthionine Sulfoximine inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Buthionine Sulfoximine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:9756946 PMID:16274885 PMID:16906435 PMID:18078826 PMID:19033395 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases response to substance
multiple interactions
ISO CYP2E1 protein results in increased susceptibility to Buthionine Sulfoximine; CYP2E1 results in increased susceptibility to Buthionine Sulfoximine
Buthionine Sulfoximine promotes the reaction [[CYP2E1 protein co-treated with Vitamin K 3] results in increased expression of KLF6 protein]; Buthionine Sulfoximine promotes the reaction [CYP2E1 protein results in increased expression of COL1A2 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin promotes the reaction [CYP2E1 protein results in increased susceptibility to Buthionine Sulfoximine]; Zinc Sulfate inhibits the reaction [CYP2E1 results in increased susceptibility to Buthionine Sulfoximine]
CTD PMID:10498651 PMID:12086689 PMID:12566070 PMID:22486562 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [CYP3A4 protein co-treated with Buthionine Sulfoximine] results in decreased abundance of Glutathione; Buthionine Sulfoximine promotes the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione]; neferine promotes the reaction [[CYP3A4 protein co-treated with Buthionine Sulfoximine] results in decreased abundance of Glutathione] CTD PMID:25451576 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dab1 DAB adaptor protein 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of DAB1 mRNA CTD PMID:15878706 NCBI chr 5:118,392,953...119,513,625
Ensembl chr 5:119,140,533...119,510,552
JBrowse link
G Dars1 aspartyl-tRNA synthetase 1 increases expression EXP Buthionine Sulfoximine results in increased expression of DARS protein CTD PMID:23736079 NCBI chr13:39,857,936...39,913,055
Ensembl chr13:39,857,936...39,913,116
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of DDIT3 protein] CTD PMID:17171638 PMID:25341683 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 decreases expression EXP Buthionine Sulfoximine results in decreased expression of DGAT2 mRNA CTD PMID:20482862 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428
JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Colforsin results in increased activity of DIO2 protein] CTD PMID:18420745 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
JBrowse link
G Dio3 iodothyronine deiodinase 3 increases activity EXP Buthionine Sulfoximine results in increased activity of DIO3 protein CTD PMID:18420745 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
JBrowse link
G Dld dihydrolipoamide dehydrogenase increases expression EXP Buthionine Sulfoximine results in increased expression of DLD protein CTD PMID:23736079 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression ISO Buthionine Sulfoximine results in increased expression of ECH1 mRNA CTD PMID:15878706 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 increases expression ISO Buthionine Sulfoximine results in increased expression of EEF1A1 mRNA CTD PMID:15878706 NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839
JBrowse link
G Eef1b2 eukaryotic translation elongation factor 1 beta 2 increases expression ISO Buthionine Sulfoximine results in increased expression of EEF1B2 mRNA CTD PMID:15878706 NCBI chr 9:64,580,009...64,582,737
Ensembl chr 9:64,579,893...64,582,737
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of EGR1 mRNA] CTD PMID:19010381 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif1a eukaryotic translation initiation factor 1A decreases expression ISO Buthionine Sulfoximine results in decreased expression of EIF1A mRNA CTD PMID:15878706 NCBI chr18:39,325,695...39,338,043
Ensembl chr18:39,325,202...39,338,696
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein] CTD PMID:25341683 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2b4 eukaryotic translation initiation factor 2B subunit delta decreases expression ISO Buthionine Sulfoximine results in decreased expression of EIF2B4 mRNA CTD PMID:15878706 NCBI chr 6:25,183,177...25,188,832
Ensembl chr 6:25,183,186...25,188,829
JBrowse link
G Eif3g eukaryotic translation initiation factor 3, subunit G decreases expression ISO Buthionine Sulfoximine results in decreased expression of EIF3G mRNA CTD PMID:15878706 NCBI chr 8:19,429,728...19,433,760
Ensembl chr 8:19,429,643...19,433,808
JBrowse link
G Esyt1 extended synaptotagmin 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of ESYT1 mRNA CTD PMID:15878706 NCBI chr 7:928,848...946,199
Ensembl chr 7:928,848...946,199
JBrowse link
G Etf1 eukaryotic translation termination factor 1 increases expression ISO Buthionine Sulfoximine results in increased expression of ETF1 mRNA CTD PMID:15707499 NCBI chr18:26,502,413...26,530,753
Ensembl chr18:26,504,080...26,530,810
JBrowse link
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit decreases expression ISO Buthionine Sulfoximine results in decreased expression of EZH1 mRNA CTD PMID:15878706 NCBI chr10:86,126,023...86,162,001
Ensembl chr10:86,126,015...86,161,921
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Copper deficiency results in increased expression of FAS mRNA] CTD PMID:9227460 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FASL mRNA CTD PMID:23986454 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 increases expression EXP Buthionine Sulfoximine results in increased expression of FKBP5 protein CTD PMID:23736079 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 increases expression ISO Buthionine Sulfoximine results in increased expression of FLT1 mRNA CTD PMID:15878706 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [FMO3 protein results in increased susceptibility to Thiourea] CTD PMID:12093470 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein] CTD PMID:19524604 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO
EXP
Buthionine Sulfoximine inhibits the reaction [Sodium Selenite results in increased expression of FOS mRNA]; Buthionine Sulfoximine promotes the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]; Glucosamine analog inhibits the reaction [Buthionine Sulfoximine results in increased expression of FOS mRNA] CTD PMID:7743507 PMID:15520183 PMID:18449455 PMID:21825963 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions ISO
EXP
Buthionine Sulfoximine promotes the reaction [Asbestos, Crocidolite results in increased expression of FOSL1 mRNA]
Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of FOSL1 mRNA]
CTD PMID:15520183 PMID:19010381 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO
EXP
[Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FOXP3 mRNA
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of FOXP3 mRNA
CTD PMID:23986454 PMID:26177832 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions
increases expression
ISO Buthionine Sulfoximine promotes the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of FTH1 mRNA]
Buthionine Sulfoximine results in increased expression of FTH1 mRNA
CTD PMID:15878706 PMID:16631525 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression EXP Buthionine Sulfoximine results in increased expression of G6PD mRNA CTD PMID:12717738 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions
increases expression
ISO [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone binds to GAPDH protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone results in decreased activity of GAPDH protein]
Buthionine Sulfoximine results in increased expression of GAPDH mRNA
CTD PMID:15878706 PMID:21827172 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gata3 GATA binding protein 3 multiple interactions
decreases expression
ISO
EXP
[Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of GATA3 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of GATA3 mRNA
Buthionine Sulfoximine results in decreased expression of GATA3 mRNA
CTD PMID:22407903 PMID:23986454 PMID:26177832 PMID:27421576 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Gc GC, vitamin D binding protein multiple interactions EXP [Aflatoxin B1 co-treated with Buthionine Sulfoximine] results in increased expression of GC mRNA CTD PMID:23288050 NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
increases expression
multiple interactions
decreases activity
ISO
EXP
Buthionine Sulfoximine results in increased activity of GCLC protein
Buthionine Sulfoximine results in increased expression of GCLC mRNA
[Buthionine Sulfoximine results in decreased activity of GCLC protein] inhibits the reaction [indenoindole results in increased abundance of Glutathione]; [Buthionine Sulfoximine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione; [Thiabendazole co-treated with Buthionine Sulfoximine] results in increased activity of GCLC protein; Buthionine Sulfoximine inhibits the reaction [GCLC protein results in decreased susceptibility to naphthalene]; Buthionine Sulfoximine inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]; Buthionine Sulfoximine inhibits the reaction [naphthalene results in increased activity of GCLC protein]; Buthionine Sulfoximine promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of GCLC mRNA]
Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione]; Buthionine Sulfoximine inhibits the reaction [GCLC results in decreased susceptibility to Cadmium Chloride]
[Buthionine Sulfoximine co-treated with Carmustine] results in decreased activity of GCLC protein; [Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of GCLC protein; Buthionine Sulfoximine inhibits the reaction [decamethrin results in increased expression of GCLC mRNA]; Buthionine Sulfoximine inhibits the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine]; Buthionine Sulfoximine inhibits the reaction [Microcystins analog results in increased expression of GCLC mRNA]
CTD PMID:7955076 PMID:10900227 PMID:10915739 PMID:10978506 PMID:11019651 More... NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions
EXP
ISO
Buthionine Sulfoximine results in increased expression of GCLM mRNA
Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione]
[Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]
CTD PMID:10978506 PMID:17724089 PMID:19010381 PMID:22864849 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gdi2 GDP dissociation inhibitor 2 decreases expression ISO Buthionine Sulfoximine results in decreased expression of GDI2 mRNA CTD PMID:15878706 NCBI chr17:66,649,616...66,676,299
Ensembl chr17:66,649,619...66,676,366
JBrowse link
G Gmfb glia maturation factor, beta increases response to substance ISO GMFB protein results in increased susceptibility to Buthionine Sulfoximine CTD PMID:12791701 NCBI chr15:20,069,923...20,081,005
Ensembl chr15:20,067,263...20,080,331
JBrowse link
G Gpi glucose-6-phosphate isomerase increases expression ISO Buthionine Sulfoximine results in increased expression of GPI1 mRNA CTD PMID:15878706 NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO
[allyl sulfide co-treated with dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate] inhibits the reaction [[Carbon Tetrachloride co-treated with Buthionine Sulfoximine] results in increased activity of GPT protein]; [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of GPT protein; [Carbon Tetrachloride co-treated with Buthionine Sulfoximine] results in increased expression of and results in increased activity of GPT protein; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of GPT protein]; Ursodeoxycholic Acid inhibits the reaction [[Carbon Tetrachloride co-treated with Buthionine Sulfoximine] results in increased activity of GPT protein]
[Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of GPT protein; [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of GPT protein; Buthionine Sulfoximine promotes the reaction [[Atorvastatin co-treated with Ciprofloxacin] results in increased expression of GPT protein]
CTD PMID:15950962 PMID:26177832 PMID:27421576 PMID:29679711 PMID:30853469 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 affects activity
multiple interactions
ISO
EXP
Buthionine Sulfoximine affects the activity of GPX1 protein
Buthionine Sulfoximine promotes the reaction [Microcystins analog results in increased expression of GPX1 mRNA]
Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of GPX1 mRNA]
CTD PMID:15707499 PMID:24964298 PMID:25341683 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression ISO Buthionine Sulfoximine results in increased expression of GPX2 mRNA CTD PMID:15878706 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO Buthionine Sulfoximine results in increased expression of GPX3 mRNA CTD PMID:15878706 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Acrolein results in decreased expression of GPX4 mRNA] CTD PMID:33421550 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Grb2 growth factor receptor bound protein 2 decreases expression ISO Buthionine Sulfoximine results in decreased expression of GRB2 mRNA CTD PMID:15878706 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation ISO Buthionine Sulfoximine results in decreased phosphorylation of GSK3B protein CTD PMID:18552690 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsn gelsolin increases expression ISO Buthionine Sulfoximine results in increased expression of GSN mRNA CTD PMID:15878706 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO
EXP
Buthionine Sulfoximine inhibits the reaction [schizandrin B results in increased activity of GSR protein]; Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of GSR protein]; Plant Extracts inhibits the reaction [Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of GSR protein]]
[Buthionine Sulfoximine co-treated with Carmustine] results in decreased activity of GSR protein; [Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of GSR protein; [cyanoginosin LR co-treated with Buthionine Sulfoximine] results in increased activity of GSR protein; Buthionine Sulfoximine inhibits the reaction [Microcystins analog results in decreased expression of GSR mRNA]; Buthionine Sulfoximine inhibits the reaction [schizandrin B results in increased activity of GSR protein]; Buthionine Sulfoximine promotes the reaction [Arsenic Trioxide results in increased expression of GSR mRNA]
CTD PMID:12967637 PMID:16288907 PMID:17119269 PMID:21772021 PMID:24634002 More... NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gss glutathione synthetase decreases activity
increases expression
EXP Buthionine Sulfoximine results in decreased activity of GSS protein
Buthionine Sulfoximine results in increased expression of GSS mRNA
CTD PMID:10904027 PMID:10978506 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions EXP Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of GSTA1 mRNA] CTD PMID:9152014 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression ISO Buthionine Sulfoximine results in increased expression of GSTM1 mRNA CTD PMID:15878706 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO Buthionine Sulfoximine results in increased expression of GSTM2 mRNA CTD PMID:15878706 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO
EXP
Buthionine Sulfoximine inhibits the reaction [GSTP1 results in decreased susceptibility to Benzo(a)pyrene]
Buthionine Sulfoximine inhibits the reaction [Microcystins analog results in increased expression of GSTP1 mRNA]
CTD PMID:19330882 PMID:24964298 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase increases expression ISO Buthionine Sulfoximine results in increased expression of HADH mRNA CTD PMID:15878706 NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353
JBrowse link
G Hbs1l HBS1-like translational GTPase decreases expression ISO Buthionine Sulfoximine results in decreased expression of HBS1L mRNA CTD PMID:15878706 NCBI chr 1:16,092,529...16,170,082
Ensembl chr 1:16,092,547...16,170,074
JBrowse link
G Hdgf heparin binding growth factor increases expression ISO Buthionine Sulfoximine results in increased expression of HDGF mRNA CTD PMID:15878706 NCBI chr 2:173,370,147...173,379,756
Ensembl chr 2:173,370,465...173,379,747
JBrowse link
G Hgf hepatocyte growth factor increases expression EXP Buthionine Sulfoximine results in increased expression of HGF protein CTD PMID:9763232 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases activity
ISO
EXP
Buthionine Sulfoximine promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of HIF1A protein]
Buthionine Sulfoximine results in increased activity of HIF1A protein
CTD PMID:11641398 PMID:11841787 PMID:17658243 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO
EXP
[Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of HMGB1 protein
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein]
CTD PMID:23986454 PMID:26177832 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hmgb2 high mobility group box 2 increases expression ISO Buthionine Sulfoximine results in increased expression of HMGB2 mRNA CTD PMID:15707499 NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
1-aminobenzotriazole inhibits the reaction [[Acetaminophen co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; 1-aminobenzotriazole inhibits the reaction [[Butylated Hydroxyanisole co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; 1-aminobenzotriazole inhibits the reaction [[Diclofenac co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; 1-aminobenzotriazole inhibits the reaction [[Ticlopidine co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]; [2-tert-butylhydroquinone co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA; [Buthionine Sulfoximine co-treated with Ascorbic Acid] promotes the reaction [Copper Sulfate results in increased expression of HMOX1 mRNA]; [Buthionine Sulfoximine co-treated with Dehydroascorbic Acid] promotes the reaction [cupric oxide results in increased expression of HMOX1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA; [monocrystalline iron oxide nanoparticle co-treated with Buthionine Sulfoximine co-treated with Dehydroascorbic Acid] results in increased expression of HMOX1 mRNA; [monocrystalline iron oxide nanoparticle co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA; Buthionine Sulfoximine promotes the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Acetaminophen results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Butylated Hydroxyanisole results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; Buthionine Sulfoximine promotes the reaction [Copper Sulfate results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [cupric oxide results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Potassium Dichromate results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Ticlopidine results in increased expression of HMOX1 mRNA]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]
Buthionine Sulfoximine results in increased expression of HMOX1 protein
Buthionine Sulfoximine results in increased expression of HMOX1 mRNA; Buthionine Sulfoximine results in increased expression of HMOX1 protein
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of HMOX1 mRNA; Buthionine Sulfoximine inhibits the reaction [decamethrin results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]
[6-formylindolo(3,2-b)carbazole co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA; [Buthionine Sulfoximine co-treated with Gefitinib] results in increased expression of HMOX1 mRNA; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA; [Pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA; Buthionine Sulfoximine promotes the reaction [[Cadmium Chloride co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [[chromium trioxide co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [[sodium arsenite co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [chromium trioxide results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 protein]; Buthionine Sulfoximine promotes the reaction [Lead results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of HMOX1 protein]
CTD PMID:7626009 PMID:9152014 PMID:11841787 PMID:12763371 PMID:16274885 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hmox2 heme oxygenase 2 affects response to substance ISO HMOX2 affects the susceptibility to Buthionine Sulfoximine CTD PMID:16181104 NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148
JBrowse link
G Hnrnpm heterogeneous nuclear ribonucleoprotein M increases expression EXP Buthionine Sulfoximine results in increased expression of HNRNPM protein CTD PMID:23736079 NCBI chr 7:14,438,703...14,476,781
Ensembl chr 7:14,438,688...14,476,762
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Buthionine Sulfoximine results in increased expression of HSP90AA1 protein CTD PMID:23736079 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression ISO Buthionine Sulfoximine results in increased expression of HSP90AB1 mRNA CTD PMID:15707499 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression EXP Buthionine Sulfoximine results in increased expression of HSPA4 protein CTD PMID:23736079 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of HSPA5 protein] CTD PMID:25341683 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO
EXP
Buthionine Sulfoximine results in increased expression of HSPA8 mRNA CTD PMID:7626009 PMID:15707499 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression
ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Buthionine Sulfoximine results in increased expression of ICAM1 protein]]; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Buthionine Sulfoximine inhibits the reaction [cinnamaldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Tetradecanoylphorbol Acetate promotes the reaction [Buthionine Sulfoximine results in increased expression of ICAM1 protein]
[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of ICAM1 mRNA
CTD PMID:11164475 PMID:20116392 PMID:20351055 PMID:29154782 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [INS1 protein results in decreased expression of IGFBP1 mRNA] CTD PMID:17213664 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Il10 interleukin 10 multiple interactions ISO
EXP
Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]; Buthionine Sulfoximine promotes the reaction [methyldithiocarbamate promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]]
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL10 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL10 mRNA]
CTD PMID:19339665 PMID:26177832 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein]; Buthionine Sulfoximine inhibits the reaction [methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]] CTD PMID:12688424 PMID:19339665 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il17a interleukin 17A multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL17A protein CTD PMID:23986454 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of IL1A mRNA; LY6G protein affects the reaction [[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of IL1A mRNA] CTD PMID:29154782 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
EXP
ISO
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL1B mRNA; Acetylcysteine inhibits the reaction [[Buthionine Sulfoximine co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased secretion of IL1B protein]; Buthionine Sulfoximine promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL1B mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL1B protein; Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Buthionine Sulfoximine promotes the reaction [hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; Buthionine Sulfoximine promotes the reaction [Tobacco Smoke Pollution results in increased secretion of and results in increased expression of IL1B protein]
CTD PMID:11970852 PMID:12433058 PMID:23986454 PMID:26149495 PMID:26177832 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL23A mRNA CTD PMID:23986454 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of IL4 protein; Buthionine Sulfoximine promotes the reaction [Methimazole results in increased expression of IL4 protein] CTD PMID:22407903 PMID:27421576 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 increases secretion
multiple interactions
EXP
ISO
Buthionine Sulfoximine results in increased secretion of IL6 protein
[Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of IL6 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL6 mRNA; [Pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of IL6 mRNA; Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Buthionine Sulfoximine inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Buthionine Sulfoximine inhibits the reaction [methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL6 mRNA; Acetylcysteine inhibits the reaction [[Buthionine Sulfoximine co-treated with Lipopolysaccharides] results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased secretion of IL6 protein]; Buthionine Sulfoximine promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL6 mRNA]
CTD PMID:11970852 PMID:12433058 PMID:15601679 PMID:19339665 PMID:23986454 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jak1 Janus kinase 1 increases expression ISO Buthionine Sulfoximine results in increased expression of JAK1 mRNA CTD PMID:15878706 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
JBrowse link
G Jak2 Janus kinase 2 decreases expression ISO Buthionine Sulfoximine results in decreased expression of JAK2 mRNA CTD PMID:15878706 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
decreases activity
ISO
EXP
Buthionine Sulfoximine inhibits the reaction [Sodium Selenite results in increased expression of JUN mRNA]; Buthionine Sulfoximine promotes the reaction [Asbestos, Crocidolite results in increased expression of JUN mRNA]; Buthionine Sulfoximine promotes the reaction [Trioxsalen analog results in decreased activity of JUN protein]; Glucosamine analog inhibits the reaction [Buthionine Sulfoximine results in increased expression of JUN mRNA]
Buthionine Sulfoximine inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]
Buthionine Sulfoximine results in decreased activity of JUN protein
CTD PMID:7626009 PMID:7743507 PMID:11341981 PMID:11841787 PMID:11849044 More... NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Asbestos, Crocidolite results in increased expression of JUNB mRNA] CTD PMID:15520183 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Kcna4 potassium voltage-gated channel subfamily A member 4 multiple interactions EXP [Carmustine co-treated with Buthionine Sulfoximine] results in decreased expression of KCNA4 protein CTD PMID:16288907 NCBI chr 3:93,756,399...93,778,004
Ensembl chr 3:93,756,446...93,769,162
JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 multiple interactions EXP [Carmustine co-treated with Buthionine Sulfoximine] results in decreased expression of KCND2 mRNA; [Carmustine co-treated with Buthionine Sulfoximine] results in decreased expression of KCND2 protein CTD PMID:16288907 NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein]; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil]; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide]; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione] CTD PMID:19608619 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Klf4 Kruppel like factor 4 multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [KLF4 results in decreased susceptibility to Cisplatin] CTD PMID:21833590 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
JBrowse link
G Klf6 Kruppel-like factor 6 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [[CYP2E1 protein co-treated with Vitamin K 3] results in increased expression of KLF6 protein] CTD PMID:22486562 NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
JBrowse link
G Kpnb1 karyopherin subunit beta 1 increases expression EXP Buthionine Sulfoximine results in increased expression of KPNB1 protein CTD PMID:23736079 NCBI chr10:82,145,662...82,174,437
Ensembl chr10:82,145,420...82,174,605
JBrowse link
G Lcn2 lipocalin 2 increases expression
multiple interactions
EXP
ISO
Buthionine Sulfoximine results in increased expression of LCN2 mRNA
[Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of LCN2 mRNA; [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of LCN2 mRNA; [zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of LCN2 mRNA; LY6G protein affects the reaction [[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of LCN2 mRNA]
Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of LCN2 mRNA]
CTD PMID:23939143 PMID:29154782 PMID:29679711 PMID:30853469 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of LEF1 protein CTD PMID:27421576 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
JBrowse link
G Lrpprc leucine-rich pentatricopeptide repeat containing increases expression EXP Buthionine Sulfoximine results in increased expression of LRPPRC protein CTD PMID:23736079 NCBI chr 6:9,859,867...9,942,294
Ensembl chr 6:9,859,867...9,942,293
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased phosphorylation of MAPK1 protein; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; Buthionine Sulfoximine promotes the reaction [chromium hexavalent ion results in increased activity of MAPK1 protein]; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased phosphorylation of MAPK1 protein]
[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased phosphorylation of MAPK1 protein; [ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in decreased phosphorylation of MAPK1 protein; Buthionine Sulfoximine promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK1 protein]
CTD PMID:8616849 PMID:17191120 PMID:21971136 PMID:24401988 PMID:26177832 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk11 mitogen-activated protein kinase 11 decreases expression
multiple interactions
ISO Buthionine Sulfoximine results in decreased expression of MAPK11 mRNA
Sodium Selenite inhibits the reaction [Buthionine Sulfoximine results in decreased expression of MAPK11 mRNA]
CTD PMID:17989939 NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation ISO Buthionine Sulfoximine results in increased phosphorylation of MAPK14 protein CTD PMID:17191120 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased phosphorylation of MAPK3 protein; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; Buthionine Sulfoximine promotes the reaction [chromium hexavalent ion results in increased activity of MAPK3 protein]; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased phosphorylation of MAPK3 protein]
[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased phosphorylation of MAPK3 protein; [ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in decreased phosphorylation of MAPK3 protein; Buthionine Sulfoximine promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK3 protein]
CTD PMID:8616849 PMID:17191120 PMID:21971136 PMID:24401988 PMID:26177832 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [antimony trioxide co-treated with Buthionine Sulfoximine] results in decreased expression of MAPK8 protein; Buthionine Sulfoximine promotes the reaction [antimony trioxide results in increased activity of MAPK8 protein]; Buthionine Sulfoximine promotes the reaction [arsenic trioxide results in increased activity of MAPK8 protein] CTD PMID:14701702 PMID:16112521 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases phosphorylation ISO Buthionine Sulfoximine results in decreased phosphorylation of MAPK9 protein CTD PMID:17191120 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mars1 methionyl-tRNA synthetase 1 increases expression EXP Buthionine Sulfoximine results in increased expression of MARS1 protein CTD PMID:23736079 NCBI chr 7:63,121,142...63,138,550
Ensembl chr 7:63,121,142...63,138,495
JBrowse link
G Mb myoglobin multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased secretion of MB protein CTD PMID:29679711 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
JBrowse link
G Mef2a myocyte enhancer factor 2a increases expression ISO Buthionine Sulfoximine results in increased expression of MEF2A mRNA CTD PMID:15878706 NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions
decreases activity
ISO Buthionine Sulfoximine inhibits the reaction [MGMT protein results in increased susceptibility to Mitomycin]
Buthionine Sulfoximine results in decreased activity of MGMT protein
CTD PMID:16039682 PMID:16950796 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Mir101-2 microRNA 101-2 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR101B mRNA CTD PMID:27421576 NCBI chr 1:226,860,371...226,860,467
Ensembl chr 1:226,860,371...226,860,467
JBrowse link
G Mir106b microRNA 106b multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR106B mRNA CTD PMID:27421576 NCBI chr12:17,043,344...17,043,425
Ensembl chr12:17,043,344...17,043,425
JBrowse link
G Mir127 microRNA 127 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR127 mRNA CTD PMID:27421576 NCBI chr 6:128,546,215...128,546,311
Ensembl chr 6:128,546,215...128,546,311
JBrowse link
G Mir133b microRNA 133b multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of MIR133B mRNA; [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR133B mRNA; [Pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of MIR133B mRNA CTD PMID:28263783 PMID:29679711 PMID:30853469 NCBI chr 9:23,098,134...23,098,217
Ensembl chr 9:23,098,134...23,098,217
JBrowse link
G Mir136 microRNA 136 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR136 mRNA CTD PMID:27421576 NCBI chr 6:128,549,096...128,549,177
Ensembl chr 6:128,549,096...128,549,177
JBrowse link
G Mir137 microRNA 137 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR137 mRNA CTD PMID:27421576 NCBI chr 2:206,480,881...206,480,982
Ensembl chr 2:206,480,884...206,480,985
JBrowse link
G Mir138-1 microRNA 138-1 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR138-1 mRNA CTD PMID:27421576 NCBI chr 8:122,300,966...122,301,064
Ensembl chr 8:122,300,966...122,301,064
JBrowse link
G Mir141 microRNA 141 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR141 mRNA CTD PMID:27421576 NCBI chr 4:157,523,239...157,523,332
Ensembl chr 4:157,523,239...157,523,332
JBrowse link
G Mir148b microRNA 148b multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR148B mRNA CTD PMID:27421576 NCBI chr 7:134,421,398...134,421,494
Ensembl chr 7:134,421,398...134,421,494
JBrowse link
G Mir151 microRNA 151 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR151 mRNA CTD PMID:27421576 NCBI chr 7:105,172,377...105,172,473 JBrowse link
G Mir184 microRNA 184 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR184 mRNA CTD PMID:27421576 NCBI chr 8:90,343,134...90,343,210
Ensembl chr 8:90,343,134...90,343,210
JBrowse link
G Mir187 microRNA 187 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR187 mRNA; [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR187 mRNA CTD PMID:27421576 NCBI chr18:15,731,194...15,731,297
Ensembl chr18:15,731,194...15,731,297
JBrowse link
G Mir188 microRNA 188 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR188 mRNA CTD PMID:27421576 NCBI chr  X:15,247,715...15,247,794
Ensembl chr  X:15,247,715...15,247,794
JBrowse link
G Mir190 microRNA 190 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR190A mRNA CTD PMID:27421576 NCBI chr 8:67,850,987...67,851,071 JBrowse link
G Mir19a microRNA 19a multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR19A mRNA CTD PMID:27421576 NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993
JBrowse link
G Mir200a microRNA 200a multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR200A mRNA CTD PMID:27421576 NCBI chr 5:166,648,494...166,648,582 JBrowse link
G Mir206 microRNA 206 multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of MIR206 mRNA; [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR206 mRNA; [Pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of MIR206 mRNA CTD PMID:28263783 PMID:29679711 PMID:30853469 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332
JBrowse link
G Mir20b microRNA 20b multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR20B mRNA CTD PMID:27421576 NCBI chr  X:132,422,211...132,422,282
Ensembl chr  X:132,422,211...132,422,282
JBrowse link
G Mir210 microRNA 210 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR210 mRNA CTD PMID:27421576 NCBI chr 1:196,326,343...196,326,452 JBrowse link
G Mir211 microRNA 211 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR211 mRNA CTD PMID:27421576 NCBI chr 1:117,777,539...117,777,644
Ensembl chr 1:117,777,539...117,777,644
JBrowse link
G Mir224 microRNA 224 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR224 mRNA CTD PMID:27421576 NCBI chr  X:150,065,088...150,065,169
Ensembl chr  X:150,065,088...150,065,169
JBrowse link
G Mir290 microRNA 290 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR292 mRNA CTD PMID:27421576 NCBI chr 1:65,964,648...65,964,728
Ensembl chr 1:65,964,648...65,964,728
JBrowse link
G Mir29b1 microRNA 29b-1 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR29B-1 mRNA CTD PMID:27421576 NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067
JBrowse link
G Mir322 microRNA 322 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR322 mRNA; [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR322 mRNA CTD PMID:27421576 NCBI chr  X:132,806,594...132,806,688 JBrowse link
G Mir324 microRNA 324 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR324 mRNA CTD PMID:27421576 NCBI chr10:54,734,680...54,734,762
Ensembl chr10:54,734,678...54,734,766
JBrowse link
G Mir328 microRNA 328 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR328 mRNA CTD PMID:27421576 NCBI chr19:33,184,766...33,184,849
Ensembl chr19:33,184,766...33,184,849
JBrowse link
G Mir337 microRNA 337 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR337 mRNA CTD PMID:27421576 NCBI chr 6:128,538,903...128,538,999
Ensembl chr 6:128,538,902...128,538,998
JBrowse link
G Mir339 microRNA 339 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR339 mRNA CTD PMID:27421576 NCBI chr12:15,277,546...15,277,641
Ensembl chr12:15,277,546...15,277,641
JBrowse link
G Mir34b microRNA 34b multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR34B mRNA CTD PMID:27421576 NCBI chr 8:51,410,244...51,410,327
Ensembl chr 8:51,410,244...51,410,327
JBrowse link
G Mir361 microRNA 361 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR361 mRNA CTD PMID:27421576 NCBI chr  X:78,246,206...78,246,275
Ensembl chr  X:78,246,206...78,246,275
JBrowse link
G Mir375 microRNA 375 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR375 mRNA CTD PMID:27421576 NCBI chr 9:76,457,911...76,457,985
Ensembl chr 9:76,457,911...76,457,985
JBrowse link
G Mir410 microRNA 410 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR410 mRNA CTD PMID:27421576 NCBI chr 6:128,758,358...128,758,433
Ensembl chr 6:128,758,354...128,758,434
JBrowse link
G Mir449a microRNA 449a multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR449A mRNA; [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR449A mRNA CTD PMID:27421576 NCBI chr 2:44,670,714...44,670,804
Ensembl chr 2:44,670,714...44,670,804
JBrowse link
G Mir450a1 microRNA 450a-1 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR450A1 mRNA CTD PMID:27421576 NCBI chr  X:132,801,380...132,801,470 JBrowse link
G Mir455 microRNA 455 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR455 mRNA CTD PMID:27421576 NCBI chr 5:76,689,313...76,689,390
Ensembl chr 5:76,689,313...76,689,390
JBrowse link
G Mir671 microRNA 671 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR671 mRNA CTD PMID:27421576 NCBI chr 4:10,580,747...10,580,827
Ensembl chr 4:10,580,738...10,580,835
JBrowse link
G Mir99a microRNA 99a multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR99A mRNA CTD PMID:27421576 NCBI chr11:16,200,443...16,200,523
Ensembl chr11:16,200,443...16,200,523
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [Buthionine Sulfoximine co-treated with SOD2 protein] results in increased expression of MMP1 mRNA; Deferoxamine inhibits the reaction [[Buthionine Sulfoximine co-treated with SOD2 protein] results in increased expression of MMP1 mRNA] CTD PMID:10464329 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of MPO protein CTD PMID:26177832 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mrps7 mitochondrial ribosomal protein S7 increases expression ISO Buthionine Sulfoximine results in increased expression of MRPS7 mRNA CTD PMID:15878706 NCBI chr10:100,843,691...100,846,838
Ensembl chr10:100,843,356...100,847,129
JBrowse link
G Mt1 metallothionein 1 multiple interactions
increases expression
increases activity
ISO
EXP
Buthionine Sulfoximine promotes the reaction [Copper results in increased activity of MT1 promoter]; Buthionine Sulfoximine promotes the reaction [Paraquat results in increased expression of MT1 mRNA]; Dactinomycin inhibits the reaction [Buthionine Sulfoximine promotes the reaction [Paraquat results in increased expression of MT1 mRNA]]
Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of MT1A mRNA]
Buthionine Sulfoximine results in increased expression of MT1A mRNA
Buthionine Sulfoximine results in increased activity of MT1 promoter
CTD PMID:7626009 PMID:8966720 PMID:9152014 PMID:14576086 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [Buthionine Sulfoximine co-treated with Gefitinib] results in increased expression of MT2 mRNA CTD PMID:32741899 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions
decreases response to substance
ISO MTF1 results in decreased susceptibility to [Buthionine Sulfoximine co-treated with cadmium sulfate]
MTF1 results in decreased susceptibility to Buthionine Sulfoximine
CTD PMID:16221973 NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]] CTD PMID:26989453 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822
JBrowse link
G Nars1 asparaginyl-tRNA synthetase 1 increases expression EXP Buthionine Sulfoximine results in increased expression of NARS1 protein CTD PMID:23736079 NCBI chr18:57,989,308...58,005,639
Ensembl chr18:57,989,308...58,005,622
JBrowse link
G Ndn necdin, MAGE family member increases expression ISO Buthionine Sulfoximine results in increased expression of NDN mRNA CTD PMID:15878706 NCBI chr 1:115,849,168...115,850,767
Ensembl chr 1:115,849,105...115,850,767
JBrowse link
G Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 increases expression ISO Buthionine Sulfoximine results in increased expression of NDUFA13 mRNA CTD PMID:15878706 NCBI chr16:19,526,633...19,533,567
Ensembl chr16:19,526,565...19,535,726
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
affects expression
increases expression
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which affects the localization of NFE2L2 protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which affects the localization of NFE2L2 protein; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein]; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil]; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide]; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione]; Buthionine Sulfoximine promotes the reaction [1,2-dihydroxynaphthalene analog results in increased activity of NFE2L2 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased phosphorylation of NFE2L2 protein]
Buthionine Sulfoximine inhibits the reaction [decamethrin results in increased expression of and affects the localization of NFE2L2 protein]; Buthionine Sulfoximine inhibits the reaction [decamethrin results in increased expression of NFE2L2 mRNA]; Buthionine Sulfoximine promotes the reaction [arsenic trioxide results in increased expression of and affects the localization of NFE2L2 protein]
Buthionine Sulfoximine affects the expression of NFE2L2 protein
Buthionine Sulfoximine results in increased expression of NFE2L2 mRNA
[6-formylindolo(3,2-b)carbazole co-treated with Buthionine Sulfoximine] results in increased expression of NFE2L2 mRNA; Buthionine Sulfoximine affects the localization of and results in increased activity of NFE2L2 protein; Buthionine Sulfoximine affects the reaction [[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to Acrolein]; Buthionine Sulfoximine affects the reaction [[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to Chlorambucil]; Buthionine Sulfoximine inhibits the reaction [Hypochlorous Acid results in increased expression of NFE2L2 mRNA]; Buthionine Sulfoximine inhibits the reaction [NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to Acrolein]]; Buthionine Sulfoximine inhibits the reaction [NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to Chlorambucil]]; Buthionine Sulfoximine inhibits the reaction [NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to cumene hydroperoxide]]
CTD PMID:17980396 PMID:18785192 PMID:19303893 PMID:19608619 PMID:20932822 More... NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:11970852 PMID:12433058 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases expression
EXP
ISO
Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
NGF protein affects the reaction [Buthionine Sulfoximine results in increased expression of NFKBIA mRNA]
CTD PMID:11970852 PMID:12433058 PMID:23472850 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ngf nerve growth factor multiple interactions
affects response to substance
increases expression
ISO Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of NGF mRNA]; NGF protein affects the reaction [Buthionine Sulfoximine results in increased expression of NFKBIA mRNA]; NGF protein affects the reaction [Buthionine Sulfoximine results in increased expression of TXN1 mRNA]; NGF protein affects the reaction [Buthionine Sulfoximine results in increased phosphorylation of and results in increased activity of NTRK1 protein]
NGF protein affects the susceptibility to Buthionine Sulfoximine
CTD PMID:23472850 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO
EXP
[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of NLRP3 mRNA
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of NLRP3 mRNA
CTD PMID:23986454 PMID:26177832 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
EXP
ISO
[Carmustine co-treated with Buthionine Sulfoximine] inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Buthionine Sulfoximine inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; Buthionine Sulfoximine promotes the reaction [Carmustine inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]]; Buthionine Sulfoximine promotes the reaction [Potassium Cyanide results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Buthionine Sulfoximine]
Buthionine Sulfoximine results in increased expression of NOS2 mRNA
[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in increased expression of NOS2 mRNA; Acetylcysteine inhibits the reaction [[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in increased expression of NOS2 mRNA]
Buthionine Sulfoximine promotes the reaction [Trioxsalen analog results in decreased expression of NOS2 mRNA]
CTD PMID:7532384 PMID:9826428 PMID:16259964 PMID:16933320 PMID:23939143 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of NPC1 mRNA CTD PMID:15878706 NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,379,482...3,425,049
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
multiple interactions
EXP
ISO
Buthionine Sulfoximine results in increased activity of NQO1 protein
Buthionine Sulfoximine results in increased expression of NQO1 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of NQO1 mRNA]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA]
[Buthionine Sulfoximine co-treated with chromium trioxide] results in increased activity of NQO1 protein; [Buthionine Sulfoximine co-treated with chromium trioxide] results in increased expression of NQO1 mRNA; [Tetrachlorodibenzodioxin co-treated with chromium trioxide co-treated with Buthionine Sulfoximine] results in increased expression of NQO1 mRNA; Buthionine Sulfoximine inhibits the reaction [chromium trioxide inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]]; Buthionine Sulfoximine inhibits the reaction [sodium arsenite promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]]; Buthionine Sulfoximine inhibits the reaction [sodium arsenite results in increased activity of NQO1 protein]; Buthionine Sulfoximine promotes the reaction [[Benzene co-treated with Toluene] results in increased activity of NQO1 protein]; Buthionine Sulfoximine promotes the reaction [Arsenic Trioxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]]; Buthionine Sulfoximine promotes the reaction [Benzene results in increased activity of NQO1 protein]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased activity of NQO1 protein]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of NQO1 mRNA]; Buthionine Sulfoximine promotes the reaction [Copper results in increased expression of NQO1 mRNA]; Buthionine Sulfoximine promotes the reaction [Copper results in increased expression of NQO1 protein]; Buthionine Sulfoximine promotes the reaction [Lead results in increased expression of NQO1 mRNA]; Buthionine Sulfoximine promotes the reaction [Lead results in increased expression of NQO1 protein]; Buthionine Sulfoximine promotes the reaction [Mercury results in increased expression of NQO1 mRNA]; Buthionine Sulfoximine promotes the reaction [Mercury results in increased expression of NQO1 protein]; Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of NQO1 mRNA]
[Buthionine Sulfoximine co-treated with Endosulfan] results in increased expression of NQO1 mRNA; Buthionine Sulfoximine promotes the reaction [Methylcholanthrene results in increased activity of NQO1 protein]; Methylcholanthrene promotes the reaction [Buthionine Sulfoximine results in increased activity of NQO1 protein]
CTD PMID:16274885 PMID:16906435 PMID:18752316 PMID:20079720 PMID:21971136 More... NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 increases expression ISO Buthionine Sulfoximine results in increased expression of NR2F2 mRNA CTD PMID:15878706 NCBI chr 1:124,008,282...124,022,521
Ensembl chr 1:124,009,181...124,022,031
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 multiple interactions ISO Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased phosphorylation of and results in increased activity of NTRK1 protein]; Buthionine Sulfoximine results in increased phosphorylation of and results in increased activity of NTRK1 protein; NGF protein affects the reaction [Buthionine Sulfoximine results in increased phosphorylation of and results in increased activity of NTRK1 protein] CTD PMID:23472850 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator decreases expression ISO Buthionine Sulfoximine results in decreased expression of NUPR1 mRNA CTD PMID:15878706 NCBI chr 1:181,213,292...181,215,327 JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression EXP Buthionine Sulfoximine results in increased expression of ODC1 protein CTD PMID:9763232 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions
affects response to substance
ISO Buthionine Sulfoximine affects the reaction [OGG1 protein affects the expression of SOD2 mRNA]
OGG1 protein affects the susceptibility to Buthionine Sulfoximine
CTD PMID:32585298 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Orm1 orosomucoid 1 increases expression EXP Buthionine Sulfoximine results in increased expression of ORM1 mRNA; Buthionine Sulfoximine results in increased expression of ORM1 protein CTD PMID:11841787 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of P4HA1 mRNA CTD PMID:15878706 NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate affects the cleavage of PARP1 protein]; Buthionine Sulfoximine promotes the reaction [wedelolactone results in increased cleavage of PARP1 protein] CTD PMID:20962031 PMID:22733624 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression
multiple interactions
EXP Buthionine Sulfoximine results in increased expression of PCK1 mRNA
SB 203580 inhibits the reaction [Buthionine Sulfoximine results in increased expression of PCK1 mRNA]
CTD PMID:16960379 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP
ISO
Buthionine Sulfoximine results in increased expression of PCNA protein
Buthionine Sulfoximine results in increased expression of PCNA mRNA
CTD PMID:9763232 PMID:15707499 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB mRNA]]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB protein]] CTD PMID:23392711 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 increases expression EXP Buthionine Sulfoximine results in increased expression of PDIA3 protein CTD PMID:23736079 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Curcumin results in increased phosphorylation of PDK1 protein] CTD PMID:17171638 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
JBrowse link
G Pfas phosphoribosylformylglycinamidine synthase increases expression EXP Buthionine Sulfoximine results in increased expression of PFAS protein CTD PMID:23736079 NCBI chr10:53,690,301...53,711,811
Ensembl chr10:53,691,626...53,708,420
JBrowse link
G Phtf1 putative homeodomain transcription factor 1 increases expression ISO Buthionine Sulfoximine results in increased expression of PHTF1 mRNA CTD PMID:15878706 NCBI chr 2:191,470,849...191,537,399
Ensembl chr 2:191,473,130...191,512,078
JBrowse link
G Plxna3 plexin A3 decreases expression ISO Buthionine Sulfoximine results in decreased expression of PLXNA3 mRNA CTD PMID:15878706 NCBI chr  X:152,115,699...152,131,608
Ensembl chr  X:152,115,819...152,131,603
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
ISO
EXP
PPARG mRNA promotes the reaction [Tamoxifen inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]]; S-ethyl glutathione inhibits the reaction [Buthionine Sulfoximine results in increased expression of PPARG mRNA]
Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of PPARG mRNA]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of PPARG protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of PPARG mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of PPARG protein]
CTD PMID:17602960 PMID:21520053 PMID:27358406 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppm1g protein phosphatase, Mg2+/Mn2+ dependent, 1G decreases expression ISO Buthionine Sulfoximine results in decreased expression of PPM1G mRNA CTD PMID:15878706 NCBI chr 6:25,153,556...25,173,763
Ensembl chr 6:25,153,556...25,173,761
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha increases expression ISO Buthionine Sulfoximine results in increased expression of PPP3CA mRNA CTD PMID:15878706 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit decreases expression ISO Buthionine Sulfoximine results in decreased expression of PPP5C mRNA CTD PMID:15878706 NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression
affects expression
ISO Buthionine Sulfoximine results in increased expression of PRDX1 mRNA
Buthionine Sulfoximine affects the expression of PRDX1 mRNA
CTD PMID:9506838 PMID:15707499 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856
JBrowse link
G Prim2 DNA primase subunit 2 decreases expression ISO Buthionine Sulfoximine results in decreased expression of PRIM2 mRNA CTD PMID:15878706 NCBI chr 9:35,692,376...35,904,521
Ensembl chr 9:35,692,376...35,903,030
JBrowse link
G Prkca protein kinase C, alpha decreases activity EXP Buthionine Sulfoximine results in decreased activity of PRKCA protein CTD PMID:11118818 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcb protein kinase C, beta decreases activity EXP Buthionine Sulfoximine results in decreased activity of PRKCB protein CTD PMID:11118818 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO
EXP
Buthionine Sulfoximine promotes the reaction [Curcumin results in increased phosphorylation of PRKCD protein]
Buthionine Sulfoximine results in increased expression of and results in increased activity of PRKCD protein; Cycloheximide inhibits the reaction [Buthionine Sulfoximine results in increased expression of PRKCD protein]
CTD PMID:11118818 PMID:17171638 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions EXP Buthionine Sulfoximine results in increased expression of and results in increased activity of PRKCE protein; Cycloheximide inhibits the reaction [Buthionine Sulfoximine results in increased expression of PRKCE protein] CTD PMID:11118818 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
JBrowse link
G Prpf19 pre-mRNA processing factor 19 increases expression EXP Buthionine Sulfoximine results in increased expression of PRPF19 protein CTD PMID:23736079 NCBI chr 1:207,541,582...207,552,664
Ensembl chr 1:207,541,595...207,552,662
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased degradation of and results in decreased expression of PTEN protein]; Buthionine Sulfoximine promotes the reaction [Cadmium results in increased degradation of and results in decreased expression of PTEN protein] CTD PMID:24449419 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of PTGS2 mRNA] CTD PMID:23376440 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2 protein tyrosine kinase 2 increases expression ISO Buthionine Sulfoximine results in increased expression of PTK2 mRNA CTD PMID:15878706 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 increases oxidation EXP Buthionine Sulfoximine results in increased oxidation of PTPN1 protein CTD PMID:20482862 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin increases expression ISO Buthionine Sulfoximine results in increased expression of PTTG1 mRNA CTD PMID:15878706 NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
JBrowse link
G Rbbp6 RB binding protein 6, ubiquitin ligase decreases expression ISO Buthionine Sulfoximine results in decreased expression of RBBP6 mRNA CTD PMID:15878706 NCBI chr 1:177,503,988...177,537,397
Ensembl chr 1:177,503,313...177,535,678
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides affects the localization of REL protein] CTD PMID:11970852 PMID:12433058 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
ISO
EXP
[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [cinnamaldehyde results in increased glutathionylation of RELA protein]; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; Buthionine Sulfoximine inhibits the reaction [carnosol results in increased glutathionylation of RELA protein]; Buthionine Sulfoximine inhibits the reaction [cinnamaldehyde inhibits the reaction [TNF protein affects the localization of RELA protein]]
Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]
Buthionine Sulfoximine promotes the reaction [Sodium Selenite results in increased expression of RELA mRNA]
Buthionine Sulfoximine results in increased expression of RELA mRNA
CTD PMID:11970852 PMID:12433058 PMID:18449455 PMID:20116392 PMID:20351055 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides affects the localization of RELB protein] CTD PMID:11970852 PMID:12433058 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507
JBrowse link
G Rorc RAR-related orphan receptor C increases expression EXP Buthionine Sulfoximine results in increased expression of RORC mRNA CTD PMID:26177832 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
JBrowse link
G Rpl10a ribosomal protein L10A increases expression ISO Buthionine Sulfoximine results in increased expression of RPL10A mRNA CTD PMID:15878706 NCBI chr20:6,388,800...6,391,358
Ensembl chr20:6,385,823...6,391,357
JBrowse link
G Rpl12 ribosomal protein L12 increases expression ISO Buthionine Sulfoximine results in increased expression of RPL12 mRNA CTD PMID:15878706 NCBI chr 3:16,264,269...16,266,645
Ensembl chr 3:16,264,251...16,266,642
JBrowse link
G Rpl3 ribosomal protein L3 decreases expression ISO Buthionine Sulfoximine results in decreased expression of RPL3 mRNA CTD PMID:15878706 NCBI chr 7:111,622,257...111,627,639
Ensembl chr 7:111,621,610...111,636,468
JBrowse link
G Rpl6 ribosomal protein L6 increases expression ISO Buthionine Sulfoximine results in increased expression of RPL6 mRNA CTD PMID:15707499 NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921
JBrowse link
G Rpl8 ribosomal protein L8 increases expression ISO Buthionine Sulfoximine results in increased expression of RPL8 mRNA CTD PMID:15878706 NCBI chr 7:108,626,194...108,628,485
Ensembl chr 7:108,622,324...108,628,482
JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 increases expression ISO Buthionine Sulfoximine results in increased expression of RPLP0 mRNA CTD PMID:15878706 NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632
JBrowse link
G Rplp1 ribosomal protein lateral stalk subunit P1 increases expression ISO Buthionine Sulfoximine results in increased expression of RPLP1 mRNA CTD PMID:15878706 NCBI chr 8:62,394,008...62,395,341
Ensembl chr 8:62,393,177...62,395,339
JBrowse link
G Rps12 ribosomal protein S12 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS12 mRNA CTD PMID:15878706 NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014
JBrowse link
G Rps14 ribosomal protein S14 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS14 mRNA CTD PMID:15878706 NCBI chr18:54,227,854...54,232,638
Ensembl chr18:54,227,854...54,233,166
JBrowse link
G Rps15 ribosomal protein S15 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS15 mRNA CTD PMID:15878706 NCBI chr 7:9,416,003...9,417,442
Ensembl chr 7:9,416,004...9,417,450
JBrowse link
G Rps20 ribosomal protein S20 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS20 mRNA CTD PMID:15878706 NCBI chr 5:16,819,313...16,820,475
Ensembl chr 5:16,819,304...16,820,475
JBrowse link
G Rps26 ribosomal protein S26 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS26 mRNA CTD PMID:15878706 NCBI chr 7:1,057,332...1,058,882 JBrowse link
G Rps6 ribosomal protein S6 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS6 mRNA CTD PMID:15878706 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Rps7 ribosomal protein S7 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS7 mRNA CTD PMID:15878706 NCBI chr 6:45,266,200...45,271,064 JBrowse link
G Rps8 ribosomal protein S8 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS8 mRNA CTD PMID:15878706 NCBI chr 5:130,630,362...130,632,932
Ensembl chr 5:130,629,716...130,633,268
JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO
EXP
[Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A8 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A8 mRNA; [Pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of S100A8 mRNA
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A8 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A8 mRNA]
CTD PMID:23986454 PMID:26177832 PMID:28263783 PMID:30853469 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO
EXP
[Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A9 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A9 mRNA; [Pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of S100A9 mRNA; [zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of S100A9 mRNA
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A9 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A9 mRNA]
CTD PMID:23986454 PMID:26177832 PMID:28263783 PMID:29154782 PMID:30853469 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Scarna15 small Cajal body-specific RNA 15 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR1839 mRNA CTD PMID:27421576 NCBI chr 1:135,484,620...135,484,683 JBrowse link
G Sele selectin E multiple interactions ISO [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of SELE mRNA] CTD PMID:21971136 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Selenow selenoprotein W decreases expression
multiple interactions
ISO Buthionine Sulfoximine results in decreased expression of SELENOW mRNA
[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased expression of SELENOW mRNA
CTD PMID:15823556 NCBI chr 1:76,599,441...76,604,514
Ensembl chr 1:76,598,779...76,604,724
Ensembl chr 1:76,598,779...76,604,724
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N decreases expression ISO Buthionine Sulfoximine results in decreased expression of SERPINA3N mRNA CTD PMID:15707499 NCBI chr 6:123,323,632...123,331,166 JBrowse link
G Serpine1 serpin family E member 1 increases expression EXP Buthionine Sulfoximine results in increased expression of SERPINE1 mRNA CTD PMID:23939143 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sesn2 sestrin 2 increases expression ISO Buthionine Sulfoximine results in increased expression of SESN2 protein CTD PMID:31323261 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 decreases expression ISO Buthionine Sulfoximine results in decreased expression of SHANK3 mRNA CTD PMID:15878706 NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374
JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 decreases expression ISO Buthionine Sulfoximine results in decreased expression of SIAH2 mRNA CTD PMID:15878706 NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950
JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions ISO [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [SLC31A1 protein results in increased import of Copper]; Buthionine Sulfoximine inhibits the reaction [SLC31A1 protein results in increased import of Copper]; glutathione diethyl ester inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [SLC31A1 protein results in increased import of Copper]] CTD PMID:23426973 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228
JBrowse link
G Snca synuclein alpha increases expression ISO Buthionine Sulfoximine results in increased expression of SNCA protein CTD PMID:15114628 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Snta1 syntrophin, alpha 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of SNTA1 mRNA CTD PMID:15878706 NCBI chr 3:142,876,285...142,906,737
Ensembl chr 3:142,876,296...142,906,709
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO Buthionine Sulfoximine results in increased expression of SOD1 mRNA CTD PMID:15707499 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases response to substance
ISO [Buthionine Sulfoximine co-treated with SOD2 protein] results in increased expression of MMP1 mRNA; Deferoxamine inhibits the reaction [[Buthionine Sulfoximine co-treated with SOD2 protein] results in increased expression of MMP1 mRNA]
Buthionine Sulfoximine affects the reaction [OGG1 protein affects the expression of SOD2 mRNA]
SOD2 protein results in increased susceptibility to Buthionine Sulfoximine
CTD PMID:8877099 PMID:10464329 PMID:15130278 PMID:32585298 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sord sorbitol dehydrogenase multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased secretion of SORD protein] CTD PMID:12763371 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133
JBrowse link
G Sox4 SRY-box transcription factor 4 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of SOX4 mRNA; [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of SOX4 protein CTD PMID:27421576 NCBI chr17:35,667,809...35,672,515
Ensembl chr17:35,667,537...35,673,665
JBrowse link
G Sp1 Sp1 transcription factor increases activity
multiple interactions
ISO Buthionine Sulfoximine results in increased activity of SP1 protein
mithramycin A inhibits the reaction [Buthionine Sulfoximine results in increased activity of SP1 protein]
CTD PMID:11261509 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Sp3 Sp3 transcription factor multiple interactions
increases activity
ISO mithramycin A inhibits the reaction [Buthionine Sulfoximine results in increased activity of SP3 protein] CTD PMID:11261509 NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of SPP1 mRNA CTD PMID:15707499 PMID:15878706 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP Buthionine Sulfoximine results in decreased expression of SREBF1 mRNA CTD PMID:20482862 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [Metformin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of SREBF2 protein]]; Buthionine Sulfoximine promotes the reaction [Hydrogen Peroxide results in increased cleavage of SREBF2 protein] CTD PMID:29499335 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Buthionine Sulfoximine results in increased expression of SRXN1 protein CTD PMID:27358234 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases activity
increases expression
EXP Buthionine Sulfoximine results in increased activity of STAT3 protein
Buthionine Sulfoximine results in increased expression of STAT3 mRNA
CTD PMID:11841787 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Syn1 synapsin I increases expression ISO Buthionine Sulfoximine results in increased expression of SYN1 mRNA CTD PMID:15878706 NCBI chr  X:1,172,208...1,227,400
Ensembl chr  X:1,172,208...1,227,396
JBrowse link
G Tbca tubulin folding cofactor A increases expression ISO Buthionine Sulfoximine results in increased expression of TBCA mRNA CTD PMID:15878706 NCBI chr 2:26,011,714...26,065,909
Ensembl chr 2:26,011,795...26,065,907
JBrowse link
G Tbx21 T-box transcription factor 21 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TBX21 mRNA CTD PMID:23986454 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR1 protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR1 protein] CTD PMID:17602960 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR2 mRNA]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR2 protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR2 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR2 protein] CTD PMID:17602960 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP Buthionine Sulfoximine results in decreased expression of THRSP mRNA CTD PMID:20482862 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Tinf2 TERF1 interacting nuclear factor 2 increases expression ISO Buthionine Sulfoximine results in increased expression of TINF2 mRNA CTD PMID:15878706 NCBI chr15:29,170,663...29,178,015
Ensembl chr15:29,170,652...29,176,984
JBrowse link
G Tle5 TLE family member 5, transcriptional modulator increases expression ISO Buthionine Sulfoximine results in increased expression of TLE5 mRNA CTD PMID:15878706 NCBI chr 7:8,143,357...8,150,295
Ensembl chr 7:8,143,357...8,150,113
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of TLR2 mRNA CTD PMID:23986454 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO
EXP
[Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR4 mRNA
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of TLR4 protein; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of TLR4 protein]
CTD PMID:23986454 PMID:26177832 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr9 toll-like receptor 9 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR9 mRNA CTD PMID:23986454 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
JBrowse link
G Tmsb10 thymosin, beta 10 increases expression ISO Buthionine Sulfoximine results in increased expression of TMSB10 mRNA CTD PMID:15707499 NCBI chr 4:105,009,959...105,011,095
Ensembl chr 4:105,009,212...105,011,028
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased susceptibility to TNF protein]; [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which co-treated with arsenite] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased susceptibility to TNF protein; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased secretion of TNF protein]; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Buthionine Sulfoximine inhibits the reaction [cinnamaldehyde inhibits the reaction [TNF protein affects the localization of RELA protein]]; Buthionine Sulfoximine inhibits the reaction [cinnamaldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Buthionine Sulfoximine promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Buthionine Sulfoximine promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Buthionine Sulfoximine promotes the reaction [TNF protein results in increased expression of CCL5 protein]; SB 203580 inhibits the reaction [Buthionine Sulfoximine promotes the reaction [TNF protein results in increased expression of CCL5 protein]]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA]
[pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of TNF mRNA; Buthionine Sulfoximine inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of TNF mRNA; [Carmustine co-treated with Buthionine Sulfoximine] inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Acetylcysteine inhibits the reaction [[Buthionine Sulfoximine co-treated with Lipopolysaccharides] results in increased secretion of TNF protein]; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased secretion of TNF protein]; Buthionine Sulfoximine inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; Buthionine Sulfoximine promotes the reaction [Carmustine inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]]; Buthionine Sulfoximine promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Buthionine Sulfoximine]
CTD PMID:7532384 PMID:11167962 PMID:11970852 PMID:12433058 PMID:15601679 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Top2b DNA topoisomerase II beta decreases expression ISO Buthionine Sulfoximine results in decreased expression of TOP2B mRNA CTD PMID:15707499 NCBI chr15:9,051,661...9,111,220
Ensembl chr15:9,051,341...9,112,085
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO
EXP
[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [Benzo(a)pyrene results in increased activity of TP53 protein]
[cyanoginosin LR co-treated with Buthionine Sulfoximine] results in increased expression of TP53 protein
Buthionine Sulfoximine results in increased expression of TRP53 protein
CTD PMID:12807757 PMID:18552690 PMID:25410294 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression EXP Buthionine Sulfoximine results in increased expression of TPI1 protein CTD PMID:23736079 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
JBrowse link
G Trap1 TNF receptor-associated protein 1 increases expression EXP Buthionine Sulfoximine results in increased expression of TRAP1 protein CTD PMID:23736079 NCBI chr10:11,464,882...11,498,931
Ensembl chr10:11,464,821...11,498,981
JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 multiple interactions ISO 4-amylcinnamoylanthranilic acid inhibits the reaction [[Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein]; [Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein; Glutathione inhibits the reaction [[Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein] CTD PMID:33309544 NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 multiple interactions EXP [Gadolinium results in decreased activity of TRPV4 protein] which results in decreased susceptibility to Buthionine Sulfoximine; [Ruthenium Red results in decreased activity of TRPV4 protein] which results in decreased susceptibility to Buthionine Sulfoximine CTD PMID:20064552 NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517
JBrowse link
G Txn1 thioredoxin 1 increases expression
multiple interactions
ISO Buthionine Sulfoximine results in increased expression of TXN1 mRNA
NGF protein affects the reaction [Buthionine Sulfoximine results in increased expression of TXN1 mRNA]
CTD PMID:23472850 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions
increases response to substance
increases expression
ISO
EXP
Buthionine Sulfoximine inhibits the reaction [sulforaphane results in increased expression of TXNRD1 mRNA]; Buthionine Sulfoximine promotes the reaction [Sodium Selenite results in increased activity of TXNRD1 protein]
TXNRD1 gene mutant form results in increased susceptibility to Buthionine Sulfoximine
Buthionine Sulfoximine results in increased expression of TXNRD1 mRNA
[Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of TXNRD1 protein
CTD PMID:12663510 PMID:16288907 PMID:19010381 PMID:24853413 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G U2af2 U2 small nuclear RNA auxiliary factor 2 increases expression EXP Buthionine Sulfoximine results in increased expression of U2AF2 protein CTD PMID:23736079 NCBI chr 1:68,760,911...68,779,730
Ensembl chr 1:68,760,924...68,778,492
JBrowse link
G Ubc ubiquitin C increases expression ISO Buthionine Sulfoximine results in increased expression of UBC mRNA CTD PMID:15878706 NCBI chr12:31,238,889...31,243,924
Ensembl chr12:31,239,152...31,243,925
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which co-treated with arsenite] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:16271621 PMID:21971136 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of VEGFA mRNA] CTD PMID:11641398 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vps26c VPS26 endosomal protein sorting factor C decreases expression ISO Buthionine Sulfoximine results in decreased expression of VPS26C mRNA CTD PMID:15878706 NCBI chr11:33,813,467...33,841,883
Ensembl chr11:33,792,389...33,841,447
JBrowse link
G Xirp1 xin actin-binding repeat containing 1 multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of XIRP1 mRNA CTD PMID:29679711 NCBI chr 8:119,744,778...119,757,547
Ensembl chr 8:119,747,419...119,757,349
JBrowse link
G Zfp422 zinc finger protein 422 decreases expression ISO Buthionine Sulfoximine results in decreased expression of ZFP422 mRNA CTD PMID:15878706 NCBI chr 4:149,885,805...149,893,287
Ensembl chr 4:149,885,600...149,893,257
JBrowse link
sulfoxaflor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity
multiple interactions
EXP sulfoxaflor results in decreased activity of CAT protein
Resveratrol affects the reaction [sulfoxaflor results in decreased activity of CAT protein]
CTD PMID:33733559 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cd3e CD3e molecule increases expression
multiple interactions
EXP sulfoxaflor results in increased expression of CD3E mRNA
Resveratrol inhibits the reaction [sulfoxaflor results in increased expression of CD3E mRNA]
CTD PMID:33733559 NCBI chr 8:45,303,848...45,315,297
Ensembl chr 8:45,303,852...45,315,022
JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit multiple interactions EXP sulfoxaflor binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein] CTD PMID:22461452 NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840
JBrowse link
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit multiple interactions EXP sulfoxaflor binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein] CTD PMID:22461452 NCBI chr10:54,501,096...54,516,418
Ensembl chr10:54,501,093...54,516,345
JBrowse link
G Chrnd cholinergic receptor nicotinic delta subunit multiple interactions EXP sulfoxaflor binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein] CTD PMID:22461452 NCBI chr 9:87,862,417...87,870,833
Ensembl chr 9:87,862,407...87,870,833
JBrowse link
G Chrng cholinergic receptor nicotinic gamma subunit multiple interactions EXP sulfoxaflor binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein] CTD PMID:22461452 NCBI chr 9:87,878,085...87,884,193 JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression
multiple interactions
EXP
ISO
sulfoxaflor results in increased expression of CYP2B1 mRNA
sulfoxaflor results in increased expression of CYP2B10 mRNA
NR1I2 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP2B10 mRNA]
CTD PMID:23607986 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP sulfoxaflor results in increased expression of CYP3A23-3A1 mRNA CTD PMID:23607986 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Ifng interferon gamma multiple interactions
increases expression
EXP Resveratrol inhibits the reaction [sulfoxaflor results in increased expression of IFNG protein] CTD PMID:33733559 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions
EXP sulfoxaflor results in increased expression of IL10 protein
Resveratrol inhibits the reaction [sulfoxaflor results in increased expression of IL10 protein]
CTD PMID:33733559 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
EXP sulfoxaflor results in increased expression of IL1B protein
Resveratrol inhibits the reaction [sulfoxaflor results in increased expression of IL1B protein]
CTD PMID:33733559 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
EXP sulfoxaflor results in increased expression of IL6 protein
Resveratrol affects the reaction [sulfoxaflor results in increased expression of IL6 protein]
CTD PMID:33733559 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgam integrin subunit alpha M increases expression
multiple interactions
EXP sulfoxaflor results in increased expression of ITGAM mRNA
Resveratrol affects the reaction [sulfoxaflor results in increased expression of ITGAM mRNA]
CTD PMID:33733559 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases response to substance
ISO NR1I2 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP2B10 mRNA]; NR1I2 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP3A11 mRNA]
NR1I2 protein results in increased susceptibility to sulfoxaflor
CTD PMID:23607986 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases response to substance
ISO NR1I3 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP3A11 mRNA]
NR1I3 protein results in increased susceptibility to sulfoxaflor
CTD PMID:23607986 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
EXP sulfoxaflor results in increased expression of TNF protein
Resveratrol inhibits the reaction [sulfoxaflor results in increased expression of TNF protein]
CTD PMID:33733559 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          sulfur atom 16418
            sulfur molecular entity 16418
              organosulfur compound 15318
                sulfoximide 331
                  2-amino-4-(S-butylsulfonimidoyl)butanoic acid + 315
                  3-methyl-1-(methylsulfonimidoyl)-3-pentanamine 0
                  N-acetyl-L-methionine sulfoximine 0
                  S,S-dimethyl-N-phenylsulfoximide 0
                  [methyl(oxido)\{1-[6-(trifluoromethyl)pyridin-3-yl]ethyl\}-lambda(6)-sulfanylidene]cyanamide + 16
                  methionine sulfoximine + 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            heteroorganic entity 19278
                              organochalcogen compound 19052
                                organosulfur compound 15318
                                  sulfoximide 331
                                    2-amino-4-(S-butylsulfonimidoyl)butanoic acid + 315
                                    3-methyl-1-(methylsulfonimidoyl)-3-pentanamine 0
                                    N-acetyl-L-methionine sulfoximine 0
                                    S,S-dimethyl-N-phenylsulfoximide 0
                                    [methyl(oxido)\{1-[6-(trifluoromethyl)pyridin-3-yl]ethyl\}-lambda(6)-sulfanylidene]cyanamide + 16
                                    methionine sulfoximine + 8
paths to the root