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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:anti-arrhythmia drug
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Accession:CHEBI:38070 term browser browse the term
Definition:A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
Synonyms:related_synonym: anti-arrhythmia agent;   antiarrhythmic agent


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adenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYL9 myosin light chain 9 decreases phosphorylation
multiple interactions
EXP Adenosine results in decreased phosphorylation of MYL9 protein
8-phenyltheophylline inhibits the reaction [Adenosine results in decreased phosphorylation of MYL9 protein]
CTD PMID:10942722 NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,296
JBrowse link
ATP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator multiple interactions
increases expression
EXP tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased expression of BCL2 protein] CTD PMID:17997382 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G CASP8 caspase 8 increases activity
multiple interactions
EXP Adenosine Triphosphate results in increased activity of CASP8 protein
tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased activity of CASP8 protein]
CTD PMID:17997382 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,470
JBrowse link
G CYCS cytochrome c, somatic affects localization
multiple interactions
EXP Adenosine Triphosphate affects the localization of CYCS protein
[Calcium co-treated with Phosphates co-treated with Adenosine Triphosphate] affects the localization of CYCS protein; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate affects the localization of CYCS protein]
CTD PMID:16489745 PMID:17997382 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G MYL9 myosin light chain 9 decreases phosphorylation
multiple interactions
EXP Adenosine Triphosphate results in decreased phosphorylation of MYL9 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [calyculin A results in increased phosphorylation of MYL9 protein]]; Adenosine Triphosphate promotes the reaction [calyculin A results in increased phosphorylation of MYL9 protein]
CTD PMID:10942722 NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,296
JBrowse link
G TNF tumor necrosis factor increases expression
multiple interactions
EXP Adenosine Triphosphate results in increased expression of TNF protein
tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased expression of TNF protein]
CTD PMID:17997382 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
digoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 decreases activity EXP Digoxin results in decreased activity of ATP1A1 protein CTD PMID:28438630 NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,506...104,384,606
JBrowse link
glyburide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 multiple interactions EXP Glyburide inhibits the reaction [Carvedilol results in decreased expression of EDN1 protein] CTD PMID:18840580 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
hydroxytyrosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP 3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein] CTD PMID:21798251 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP 3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein] CTD PMID:21798251 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
losartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen affects activity EXP Losartan affects the activity of AGT protein CTD PMID:21127344 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
ouabain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 decreases activity EXP Ouabain results in decreased activity of ATP1A1 protein CTD PMID:28438630 NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,506...104,384,606
JBrowse link
G CASP3 caspase 3 decreases cleavage EXP Ouabain results in decreased cleavage of CASP3 protein CTD PMID:28438630 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
verapamil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions EXP Verapamil inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines] CTD PMID:21056966 NCBI chr 9:93,171,371...93,262,124 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 876
    role 856
      application 494
        pharmaceutical 435
          drug 435
            cardiovascular drug 69
              anti-arrhythmia drug 12
                (2R,3S,2'R)-nadolol + 0
                (S)-timolol (anhydrous) + 0
                (S)-timolol hemihydrate 0
                (S)-timolol maleate 0
                2-(4-hydroxyphenyl)ethanol + 2
                3'''-O-acetyldigitoxin 0
                N-acetylprocainamide 0
                acebutolol 0
                acebutolol hydrochloride 0
                acetylstrophanthidin 0
                adenosine + 5
                alprenolol + 0
                atenolol + 0
                atropine + 0
                beclomethasone dipropionate 0
                bepridil + 0
                bevantolol + 0
                bevantolol hydrochloride + 0
                bisoprolol + 0
                bretylium + 0
                bretylium tosylate 0
                carteolol 0
                carteolol hydrochloride 0
                cinalukast 0
                clidinium + 0
                clidinium bromide 0
                deslanoside 0
                devapamil 0
                digoxin + 1
                disopyramide + 0
                dofetilide 0
                dronedarone 0
                encainide + 0
                encainide hydrochloride 0
                enprofylline + 0
                esmolol + 0
                esmolol hydrochloride 0
                ethylisopropylamiloride 0
                felodipine 0
                flecainide 0
                flecainide acetate 0
                glyburide 1
                levosimendan 0
                lidocaine + 0
                lidocaine hydrochloride + 0
                lidocaine hydrochloride monohydrate 0
                losartan + 1
                magnesium sulfate + 0
                metipranolol 0
                metipranolol hydrochloride 0
                mexiletine + 0
                mexiletine hydrochloride 0
                montelukast + 0
                moricizine + 0
                moricizine hydrochloride 0
                nadolol 0
                norverapamil 0
                ouabain 2
                pilsicainide 0
                practolol 0
                procainamide + 0
                procainamide hydrochloride 0
                propafenone 0
                propafenone hydrochloride 0
                propranolol + 0
                quinidine + 0
                ranolazine 0
                sotalol 0
                sotalol hydrochloride 0
                tedisamil 0
                tocainide 0
                trans-piceid 0
                verapamil 1
paths to the root