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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:anti-arrhythmia drug
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Accession:CHEBI:38070 term browser browse the term
Definition:A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
Synonyms:related_synonym: anti-arrhythmia agent;   antiarrhythmic agent


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(S)-timolol (anhydrous) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenergic receptor, beta 1 multiple interactions ISO Timolol binds to and results in decreased activity of ADRB1 protein; Timolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP] CTD PMID:11436944, PMID:15060759 NCBI chr19:56,722,117...56,725,150
Ensembl chr19:56,722,199...56,733,113
JBrowse link
G Adrb2 adrenergic receptor, beta 2 multiple interactions ISO [Timolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; Timolol binds to and results in decreased activity of ADRB2 protein CTD PMID:11436944, PMID:17925438 NCBI chr18:62,177,713...62,179,981
Ensembl chr18:62,177,816...62,179,959
JBrowse link
G Aoc1 amine oxidase, copper-containing 1 multiple interactions ISO Timolol inhibits the reaction [Epinephrine results in increased activity of AOC1 protein] CTD PMID:2860926 NCBI chr 6:48,895,255...48,909,188
Ensembl chr 6:48,872,896...48,909,188
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 affects response to substance ISO CYP2D6 gene SNP affects the susceptibility to Timolol CTD PMID:19284319, PMID:20925579 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO [Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; [Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased phosphorylation of MAPK1 protein]; Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Gadolinium inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; W 7 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]
CTD PMID:11914123, PMID:18977218 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO [Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; [Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased phosphorylation of MAPK3 protein]; Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Gadolinium inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; W 7 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]
CTD PMID:11914123, PMID:18977218 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Rgs3 regulator of G-protein signaling 3 multiple interactions ISO RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18977218 NCBI chr 4:62,559,835...62,703,019
Ensembl chr 4:62,559,847...62,704,001
JBrowse link
G Rgs4 regulator of G-protein signaling 4 multiple interactions ISO RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18977218 NCBI chr 1:169,741,477...169,747,642
Ensembl chr 1:169,741,477...169,747,642
JBrowse link
2-(4-hydroxyphenyl)ethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6pc glucose-6-phosphatase, catalytic multiple interactions ISO 4-hydroxyphenylethanol inhibits the reaction [Streptozocin results in increased activity of G6PC protein] CTD PMID:25641191 NCBI chr11:101,367,716...101,377,903
Ensembl chr11:101,367,561...101,377,903
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked multiple interactions ISO 4-hydroxyphenylethanol inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] CTD PMID:25641191 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP 4-hydroxyphenylethanol inhibits the reaction [[Lipids results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone] CTD PMID:18081942 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
3'-phospho-5'-adenylyl sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) multiple interactions ISO [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone] CTD PMID:20545351 NCBI chr 8:67,494,875...67,502,644
Ensembl chr 8:67,494,858...67,502,584
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO [NQO1 protein co-treated with NADP co-treated with Phosphoadenosine Phosphosulfate co-treated with SULT1A1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone CTD PMID:20545351 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G P2ry1 purinergic receptor P2Y, G-protein coupled 1 decreases activity ISO Phosphoadenosine Phosphosulfate results in decreased activity of P2RY1 protein CTD PMID:22273509 NCBI chr 3:61,002,785...61,008,982
Ensembl chr 3:61,002,795...61,008,982
JBrowse link
G Sult1a1 sulfotransferase family 1A, phenol-preferring, member 1 multiple interactions
increases sulfation
ISO 2,2',3,4,4',5',6-heptabromodiphenyl ether inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; [NQO1 protein co-treated with NADP co-treated with Phosphoadenosine Phosphosulfate co-treated with SULT1A1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; Halogenated Diphenyl Ethers analog inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; pentabrominated diphenyl ether 100 inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; Pentachlorophenol inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; tetrabromobisphenol A inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; tribromodiphenyl ether 28 inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]
SULT1A1 protein results in increased sulfation of Phosphoadenosine Phosphosulfate
CTD PMID:11425650, PMID:16601080, PMID:20545351 NCBI chr 7:126,672,865...126,690,443
Ensembl chr 7:126,672,865...126,676,432
JBrowse link
G Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 multiple interactions ISO [Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol; Celecoxib affects the reaction [[Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol]; SULT2A1 protein affects the metabolism of [Phosphoadenosine Phosphosulfate co-treated with Ethinyl Estradiol] CTD PMID:15483193 NCBI chr 7:13,796,246...13,837,410
Ensembl chr 7:13,796,246...13,837,409
JBrowse link
3-iodobenzyl-5'-N-methylcarboxamidoadenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora3 adenosine A3 receptor multiple interactions ISO
EXP
2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]
[N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Dizocilpine Maleate; [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Scopolamine; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein
CTD PMID:12672554, PMID:15452191, PMID:19966059 NCBI chr 3:105,904,421...105,908,928
Ensembl chr 3:105,870,858...105,908,926
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO Pertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in increased phosphorylation of AKT1 protein] CTD PMID:16116186 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression
decreases response to substance
ISO N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of BIRC3 mRNA
BIRC3 protein results in decreased susceptibility to N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine
CTD PMID:16088125 NCBI chr 9:7,847,468...7,873,205
Ensembl chr 9:7,848,699...7,873,186
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases response to substance ISO BIRC5 protein results in decreased susceptibility to N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine CTD PMID:16088125 NCBI chr11:117,849,237...117,855,743
Ensembl chr11:117,849,251...117,855,743
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA] CTD PMID:15452191 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Il12a interleukin 12a multiple interactions ISO N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]; Pertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]; wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]] CTD PMID:16116186 NCBI chr 3:68,690,644...68,698,550
Ensembl chr 3:68,690,644...68,698,547
JBrowse link
G Il12b interleukin 12b multiple interactions ISO N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]; Pertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]; wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]] CTD PMID:16116186 NCBI chr11:44,400,063...44,414,677
Ensembl chr11:44,400,063...44,414,033
JBrowse link
G Naip2 NLR family, apoptosis inhibitory protein 2 decreases response to substance
decreases expression
ISO NAIP protein results in decreased susceptibility to N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine
N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of NAIP mRNA
CTD PMID:16088125 NCBI chr13:100,144,063...100,202,122
Ensembl chr13:100,144,063...100,202,092
JBrowse link
G Nppa natriuretic peptide type A multiple interactions ISO 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:15452191, PMID:19966059 NCBI chr 4:148,000,722...148,002,074
Ensembl chr 4:148,000,722...148,002,079
JBrowse link
G Rgs2 regulator of G-protein signaling 2 multiple interactions ISO N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA] CTD PMID:15452191 NCBI chr 1:143,999,338...144,004,149
Ensembl chr 1:143,999,338...144,004,161
JBrowse link
G Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 multiple interactions ISO N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein] CTD PMID:15452191 NCBI chr 4:133,369,711...133,423,702
Ensembl chr 4:133,369,706...133,423,702
JBrowse link
5'-S-methyl-5'-thioadenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a1 collagen, type I, alpha 1 decreases expression ISO 5'-methylthioadenosine results in decreased expression of COL1A1 mRNA CTD PMID:15983038 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Col1a2 collagen, type I, alpha 2 decreases expression ISO 5'-methylthioadenosine results in decreased expression of COL1A2 mRNA CTD PMID:15983038 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions
increases abundance
EXP Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 5'-methylthioadenosine] CTD PMID:27469509 NCBI chr 7:80,094,845...80,118,608
Ensembl chr 7:80,094,846...80,115,392
JBrowse link
G Ifng interferon gamma multiple interactions EXP 5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IFNG mRNA] CTD PMID:17080400 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP 5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA] CTD PMID:17080400 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il2 interleukin 2 multiple interactions EXP 5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL2 mRNA] CTD PMID:17080400 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il6 interleukin 6 multiple interactions EXP 5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA] CTD PMID:17080400 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Ltb lymphotoxin B multiple interactions EXP 5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of LTB mRNA] CTD PMID:17080400 NCBI chr17:35,194,507...35,196,305
Ensembl chr17:35,194,439...35,196,320
JBrowse link
acebutolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenergic receptor, beta 1 multiple interactions
increases activity
ISO [Acebutolol co-treated with ADRB1] results in increased abundance of Cyclic AMP; CGP 20712A inhibits the reaction [[Acebutolol co-treated with ADRB1] results in increased abundance of Cyclic AMP]; CGP 20712A inhibits the reaction [Acebutolol results in increased activity of ADRB1 protein] CTD PMID:12761341 NCBI chr19:56,722,117...56,725,150
Ensembl chr19:56,722,199...56,733,113
JBrowse link
G Adrb2 adrenergic receptor, beta 2 multiple interactions ISO [Acebutolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr18:62,177,713...62,179,981
Ensembl chr18:62,177,816...62,179,959
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO Acebutolol results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO [Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein CTD PMID:17925438 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO [Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Ren1 renin 1 structural decreases activity ISO Acebutolol results in decreased activity of REN protein CTD PMID:6110712, PMID:6118215 NCBI chr 1:133,350,674...133,360,320
Ensembl chr 1:133,350,510...133,360,325
JBrowse link
acetoacetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 affects binding ISO acetoacetyl CoA binds to HSD17B2 protein CTD PMID:25526675 NCBI chr 8:117,700,982...117,759,030
Ensembl chr 8:117,701,904...117,759,027
JBrowse link
acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acly ATP citrate lyase increases abundance EXP ACLY protein results in increased abundance of Acetyl Coenzyme A CTD PMID:28077572 NCBI chr11:100,476,352...100,528,000
Ensembl chr11:100,476,353...100,528,000
JBrowse link
G App amyloid beta (A4) precursor protein affects localization
increases secretion
multiple interactions
EXP
ISO
APP protein affects the localization of Acetyl Coenzyme A
Acetyl Coenzyme A results in increased secretion of APP protein modified form
Acetyl Coenzyme A inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified form]
IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A]
CTD PMID:16122837, PMID:22906069 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Crat carnitine acetyltransferase decreases activity ISO Acetyl Coenzyme A deficiency results in decreased activity of CRAT protein CTD PMID:8075222 NCBI chr 2:30,400,476...30,416,017
Ensembl chr 2:30,400,471...30,415,813
JBrowse link
G Ercc6 excision repair cross-complementing rodent repair deficiency, complementation group 6 decreases abundance
multiple interactions
ISO ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A
3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]
CTD PMID:25440059 NCBI chr14:32,513,291...32,580,990
Ensembl chr14:32,513,521...32,580,990
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A] CTD PMID:16122837 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Kat2b K(lysine) acetyltransferase 2B affects binding EXP Acetyl Coenzyme A binds to KAT2B protein CTD PMID:28077572 NCBI chr17:53,566,774...53,672,721
Ensembl chr17:53,566,861...53,672,720
JBrowse link
G Metrnl meteorin, glial cell differentiation regulator-like multiple interactions EXP METRNL protein inhibits the reaction [Dietary Fats results in decreased abundance of Acetyl Coenzyme A] CTD PMID:30213948 NCBI chr11:121,702,427...121,717,389
Ensembl chr11:121,701,544...121,716,306
JBrowse link
G Nat1 N-acetyl transferase 1 multiple interactions
affects binding
ISO [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; Acetyl Coenzyme A inhibits the reaction [Cyanamide results in decreased activity of NAT1 protein]; Acetyl Coenzyme A inhibits the reaction [Iodoacetamide results in decreased activity of NAT1 protein]
Acetyl Coenzyme A binds to NAT1 protein
CTD PMID:20545351, PMID:22835378 NCBI chr 8:67,490,968...67,492,531
Ensembl chr 8:67,480,921...67,492,104
JBrowse link
G Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) multiple interactions ISO [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone] CTD PMID:20545351 NCBI chr 8:67,494,875...67,502,644
Ensembl chr 8:67,494,858...67,502,584
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone CTD PMID:20545351 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
acryloyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Echs1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial increases abundance ISO ECHS1 gene mutant form results in increased abundance of acryloyl-coenzyme A CTD PMID:25125611 NCBI chr 7:140,105,710...140,116,421
Ensembl chr 7:140,105,710...140,116,476
JBrowse link
G Hibch 3-hydroxyisobutyryl-Coenzyme A hydrolase increases abundance ISO HIBCH gene mutant form results in increased abundance of acryloyl-coenzyme A CTD PMID:25125611 NCBI chr 1:52,845,038...52,920,986
Ensembl chr 1:52,844,929...52,920,986
JBrowse link
acteoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor decreases localization
multiple interactions
ISO acteoside results in decreased localization of AHR protein
acteoside promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein]
CTD PMID:21756928 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator increases localization ISO acteoside results in increased localization of ARNT protein CTD PMID:21756928 NCBI chr 3:95,434,367...95,497,240
Ensembl chr 3:95,434,388...95,497,240
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 decreases secretion
multiple interactions
decreases expression
ISO acteoside results in decreased secretion of CCL2 protein
acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]
acteoside results in decreased expression of CCL2 mRNA
CTD PMID:21756928, PMID:21967610 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO acteoside results in decreased expression of CCND1 protein CTD PMID:17634406 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO acteoside results in decreased expression of CCND2 protein CTD PMID:17634406 NCBI chr 6:127,125,162...127,152,188
Ensembl chr 6:127,125,162...127,152,193
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO acteoside results in decreased expression of CCND3 protein CTD PMID:17634406 NCBI chr17:47,505,051...47,599,689
Ensembl chr17:47,505,051...47,599,691
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO acteoside results in decreased expression of CCNE1 protein CTD PMID:17634406 NCBI chr 7:38,097,984...38,107,490
Ensembl chr 7:38,097,984...38,107,534
JBrowse link
G Cdk2 cyclin-dependent kinase 2 multiple interactions ISO acteoside results in decreased expression of and results in decreased activity of CDK2 protein CTD PMID:17634406 NCBI chr10:128,697,938...128,705,051
Ensembl chr10:128,697,939...128,705,031
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases activity
ISO acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]
acteoside results in decreased activity of CDK4 protein
CTD PMID:17634406 NCBI chr10:127,063,535...127,067,288
Ensembl chr10:127,063,534...127,067,920
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]; acteoside results in decreased expression of and results in decreased activity of CDK6 protein CTD PMID:17634406 NCBI chr 5:3,341,004...3,531,008
Ensembl chr 5:3,341,485...3,531,008
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions
increases expression
ISO acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]
acteoside results in increased expression of CDKN1A mRNA; acteoside results in increased expression of CDKN1A protein
CTD PMID:17634406 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression
ISO acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]
acteoside results in increased expression of CDKN1B mRNA; acteoside results in increased expression of CDKN1B protein
CTD PMID:17634406 NCBI chr 6:134,920,401...134,925,525
Ensembl chr 6:134,920,401...134,925,513
JBrowse link
G Cxcl10 chemokine (C-X-C motif) ligand 10 decreases secretion
decreases expression
multiple interactions
ISO acteoside results in decreased secretion of CXCL10 protein
acteoside results in decreased expression of CXCL10 mRNA
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [PD168393 results in increased secretion of CXCL10 protein]; acteoside promotes the reaction [leptomycin B results in decreased secretion of CXCL10 protein]
CTD PMID:21756928, PMID:21967610 NCBI chr 5:92,346,638...92,348,889
Ensembl chr 5:92,346,638...92,348,889
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions
decreases expression
decreases secretion
ISO [acteoside co-treated with TGFA protein] results in increased expression of CXCL8 mRNA; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]; acteoside inhibits the reaction [leptomycin B results in increased secretion of CXCL8 protein]; acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL8 mRNA]
acteoside results in decreased expression of CXCL8 mRNA
acteoside results in decreased secretion of CXCL8 protein
CTD PMID:21371465, PMID:21756928, PMID:21967610, PMID:23527233 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO acteoside results in increased expression of CYP1A1 mRNA CTD PMID:21756928 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO acteoside inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein] CTD PMID:14672760 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein] CTD PMID:17634406 NCBI chr 2:154,559,400...154,569,892
Ensembl chr 2:154,559,407...154,569,892
JBrowse link
G Egfr epidermal growth factor receptor decreases phosphorylation
multiple interactions
ISO acteoside results in decreased phosphorylation of EGFR protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein]
CTD PMID:21756928, PMID:21967610 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO acteoside results in decreased expression of ICAM1 mRNA CTD PMID:21371465 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
ISO acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]
acteoside results in decreased expression of IFNG mRNA
CTD PMID:21371465, PMID:21756928 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]
acteoside results in decreased expression of IL6 mRNA
CTD PMID:21756928 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Itgb2 integrin beta 2 multiple interactions ISO acteoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]; acteoside inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein] CTD PMID:16393473 NCBI chr10:77,530,329...77,565,708
Ensembl chr10:77,530,252...77,565,708
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
decreases phosphorylation
ISO acteoside results in increased phosphorylation of MAPK1 protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]
acteoside results in decreased phosphorylation of MAPK1 protein
CTD PMID:21756928, PMID:23527233 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation
multiple interactions
increases phosphorylation
ISO acteoside results in decreased phosphorylation of MAPK3 protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]
acteoside results in increased phosphorylation of MAPK3 protein
CTD PMID:21756928, PMID:23527233 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Nox1 NADPH oxidase 1 decreases activity ISO acteoside results in decreased activity of NOX1 protein CTD PMID:16393473 NCBI chr  X:134,086,421...134,137,711
Ensembl chr  X:134,086,421...134,221,956
JBrowse link
G Ptgds prostaglandin D2 synthase (brain) affects binding ISO acteoside binds to PTGDS protein CTD PMID:26456343 NCBI chr 2:25,466,709...25,470,110
Ensembl chr 2:25,466,709...25,470,046
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [acteoside co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTGS2 mRNA CTD PMID:21756928 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases phosphorylation
ISO [acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein] CTD PMID:17634406 NCBI chr14:73,192,858...73,325,951
Ensembl chr14:73,183,673...73,325,822
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) decreases phosphorylation
multiple interactions
increases phosphorylation
ISO acteoside results in decreased phosphorylation of RELA protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
acteoside results in increased phosphorylation of RELA protein
CTD PMID:21756928, PMID:23527233 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Smad2 SMAD family member 2 increases phosphorylation ISO acteoside results in increased phosphorylation of SMAD2 protein CTD PMID:17634406 NCBI chr18:76,241,090...76,311,748
Ensembl chr18:76,241,580...76,310,963
JBrowse link
G Smad3 SMAD family member 3 increases phosphorylation ISO acteoside results in increased phosphorylation of SMAD3 protein CTD PMID:17634406 NCBI chr 9:63,646,766...63,757,994
Ensembl chr 9:63,646,767...63,757,994
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial decreases expression ISO acteoside results in decreased expression of SOD2 mRNA CTD PMID:21371465 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO [acteoside co-treated with TGFA protein] results in increased expression of CXCL8 mRNA; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein] CTD PMID:21756928, PMID:21967610 NCBI chr 6:86,195,038...86,275,744
Ensembl chr 6:86,195,223...86,275,719
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO acteoside results in increased expression of TGFB1 mRNA CTD PMID:17634406 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein] CTD PMID:21756928 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO acteoside results in decreased expression of VCAM1 mRNA CTD PMID:21371465 NCBI chr 3:116,110,020...116,129,688
Ensembl chr 3:116,109,949...116,129,688
JBrowse link
adenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase decreases metabolic processing
increases metabolic processing
ISO ADA alternative form results in decreased metabolism of Adenosine
ADA protein results in increased metabolism of Adenosine
CTD PMID:16221767 NCBI chr 2:163,726,571...163,750,239
Ensembl chr 2:163,726,584...163,750,239
JBrowse link
G Adora1 adenosine A1 receptor multiple interactions
affects binding
ISO Adenosine analog binds to and affects the activity of ADORA1 protein; Adenosine analog binds to and results in decreased activity of ADORA1 protein; PD 81723 affects the reaction [Adenosine analog binds to and affects the activity of ADORA1 protein]; VUF 5455 affects the reaction [Adenosine analog binds to and affects the activity of ADORA1 protein]
[lead acetate results in increased expression of ADORA1 protein] which results in increased abundance of Adenosine; Adenosine analog binds to and results in increased activity of ADORA1 protein
Adenosine binds to ADORA1 protein
CTD PMID:10649980, PMID:11520205, PMID:18404447, PMID:20571079, PMID:20932874 NCBI chr 1:134,199,215...134,235,457
Ensembl chr 1:134,199,223...134,235,431
JBrowse link
G Adora2a adenosine A2a receptor multiple interactions
affects binding
ISO Adenosine analog binds to and results in decreased activity of ADORA2A protein; Adenosine promotes the reaction [Lipopolysaccharides results in increased expression of ADORA2A mRNA]
Adenosine binds to ADORA2A protein
CTD PMID:18404447, PMID:20067761 NCBI chr10:75,316,877...75,334,792
Ensembl chr10:75,316,877...75,334,784
JBrowse link
G Adora2b adenosine A2b receptor affects response to substance EXP ADORA2B protein affects the susceptibility to Adenosine CTD PMID:16920807 NCBI chr11:62,248,984...62,266,452
Ensembl chr11:62,248,984...62,266,453
JBrowse link
G Adora3 adenosine A3 receptor multiple interactions
affects binding
increases expression
ISO Adenosine analog binds to and affects the activity of ADORA3 protein; Adenosine analog binds to and results in decreased activity of ADORA3 protein; Adenosine analog binds to and results in increased activity of ADORA3 protein; PD 81723 affects the reaction [Adenosine analog binds to and affects the activity of ADORA3 protein]; VUF 5455 affects the reaction [Adenosine analog binds to and affects the activity of ADORA3 protein]
Adenosine binds to ADORA3 protein
Adenosine results in increased expression of ADORA3 mRNA
CTD PMID:11520205, PMID:18404447, PMID:20067761, PMID:20571079 NCBI chr 3:105,904,421...105,908,928
Ensembl chr 3:105,870,858...105,908,926
JBrowse link
G Alpi alkaline phosphatase, intestinal multiple interactions ISO Adenosine inhibits the reaction [Methotrexate results in increased activity of ALPI protein] CTD PMID:16598758 NCBI chr 1:87,098,002...87,101,606
Ensembl chr 1:87,098,002...87,101,606
JBrowse link
G Ampd2 adenosine monophosphate deaminase 2 multiple interactions ISO [tofacitinib results in decreased expression of AMPD2 protein] which affects the abundance of Adenosine CTD PMID:25496463 NCBI chr 3:108,074,059...108,086,687
Ensembl chr 3:108,074,062...108,086,651
JBrowse link
G Bax BCL2-associated X protein increases localization
multiple interactions
ISO Adenosine results in increased localization of BAX protein
Thymidine inhibits the reaction [Adenosine results in increased localization of BAX protein]
CTD PMID:11570579 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression
multiple interactions
ISO Adenosine results in decreased expression of BCL2L1 mRNA; Adenosine results in decreased expression of BCL2L1 protein
Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 mRNA]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 protein]
CTD PMID:20063052 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO Adenosine results in decreased expression of BIRC2 mRNA; Adenosine results in decreased expression of BIRC2 protein CTD PMID:20063052 NCBI chr 9:7,818,226...7,837,131
Ensembl chr 9:7,818,227...7,837,064
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO Adenosine results in decreased expression of BIRC3 mRNA CTD PMID:20063052 NCBI chr 9:7,847,468...7,873,205
Ensembl chr 9:7,848,699...7,873,186
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP3 protein]; Thymidine inhibits the reaction [Adenosine results in increased activity of CASP3 protein] CTD PMID:11570579, PMID:16469385, PMID:17303086, PMID:20063052 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
ISO Adenosine results in increased activity of CASP8 protein
Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP8 protein]
CTD PMID:16469385, PMID:17303086 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO Adenosine results in increased activity of CASP9 protein
Thymidine inhibits the reaction [Adenosine results in increased activity of CASP9 protein]
CTD PMID:11570579, PMID:16469385 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cd14 CD14 antigen increases expression ISO Adenosine results in increased expression of CD14 mRNA CTD PMID:21538184 NCBI chr18:36,725,064...36,726,815
Ensembl chr18:36,725,067...36,726,798
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression
multiple interactions
ISO Adenosine results in decreased expression of CFLAR mRNA; Adenosine results in decreased expression of CFLAR mRNA alternative form; Adenosine results in decreased expression of CFLAR protein
Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA alternative form]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR protein]
CTD PMID:17303086 NCBI chr 1:58,711,311...58,758,884
Ensembl chr 1:58,711,508...58,758,884
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator increases activity
multiple interactions
ISO Adenosine results in increased activity of CFTR protein
[Isoproterenol co-treated with Adenosine] results in increased activity of CFTR protein
CTD PMID:15039139 NCBI chr 6:18,170,687...18,322,770
Ensembl chr 6:18,170,687...18,322,768
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; [Adenosine co-treated with Homocysteine] results in decreased expression of CXCL8 mRNA CTD PMID:24224954 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases expression
multiple interactions
ISO Adenosine results in increased expression of DIABLO mRNA; Adenosine results in increased expression of DIABLO protein
Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO mRNA]; Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO protein]
CTD PMID:20063052 NCBI chr 5:123,511,330...123,524,164
Ensembl chr 5:123,509,765...123,524,176
JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases expression
multiple interactions
ISO Adenosine results in decreased expression of DPP4 mRNA; Adenosine results in decreased expression of DPP4 protein
[Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 mRNA; [Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 protein; [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 mRNA; [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 protein
CTD PMID:16611738 NCBI chr 2:62,330,073...62,412,315
Ensembl chr 2:62,330,073...62,412,231
JBrowse link
G Fadd Fas (TNFRSF6)-associated via death domain decreases expression
multiple interactions
ISO Adenosine results in decreased expression of FADD mRNA
Dipyridamole inhibits the reaction [Adenosine results in decreased expression of FADD mRNA]
CTD PMID:17303086 NCBI chr 7:144,578,323...144,582,441
Ensembl chr 7:144,577,318...144,582,463
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) increases expression
multiple interactions
ISO
EXP
Adenosine results in increased expression of FASLG protein
[Adenosine co-treated with Coformycin] results in decreased expression of FASL mRNA
CTD PMID:11992407, PMID:16419169 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Gzmb granzyme B multiple interactions EXP [Adenosine co-treated with Coformycin] results in decreased expression of GZMB mRNA CTD PMID:11992407 NCBI chr14:56,258,836...56,262,334
Ensembl chr14:56,258,838...56,262,260
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit increases expression ISO Adenosine results in increased expression of HIF1A mRNA CTD PMID:20067761 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions
increases abundance
EXP Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Adenosine] CTD PMID:27469509 NCBI chr 7:80,094,845...80,118,608
Ensembl chr 7:80,094,846...80,115,392
JBrowse link
G Ifng interferon gamma multiple interactions EXP [Adenosine co-treated with Coformycin] results in decreased expression of IFNG protein CTD PMID:11992407 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
EXP Adenosine promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
Adenosine results in increased expression of IL10 mRNA; Adenosine results in increased expression of IL10 protein
CTD PMID:11023991 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il12b interleukin 12b decreases expression
multiple interactions
EXP Adenosine results in decreased expression of IL12B protein
Adenosine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]
CTD PMID:11023991 NCBI chr11:44,400,063...44,414,677
Ensembl chr11:44,400,063...44,414,033
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Adenosine inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Adenosine inhibits the reaction [IL1B protein results in increased expression of IL1R1]; Adenosine inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Adenosine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein] CTD PMID:24878381 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il1r1 interleukin 1 receptor, type I multiple interactions ISO Adenosine inhibits the reaction [IL1B protein results in increased expression of IL1R1] CTD PMID:24878381 NCBI chr 1:40,222,480...40,316,201
Ensembl chr 1:40,225,080...40,317,257
JBrowse link
G Il2 interleukin 2 multiple interactions EXP [Adenosine co-treated with Coformycin] results in decreased expression of IL2 protein CTD PMID:11992407 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Ly96 lymphocyte antigen 96 increases expression ISO Adenosine results in increased expression of LY96 mRNA CTD PMID:21538184 NCBI chr 1:16,688,456...16,709,605
Ensembl chr 1:16,688,051...16,709,611
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO [Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 mRNA; [Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 protein CTD PMID:16611738 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO Adenosine results in decreased phosphorylation of MAPK3 protein
[Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 mRNA; [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 protein
CTD PMID:16611738 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Myc myelocytomatosis oncogene decreases expression
multiple interactions
ISO Adenosine results in decreased expression of MYC protein
Thymidine inhibits the reaction [Adenosine results in decreased expression of MYC protein]; Uridine inhibits the reaction [Adenosine results in decreased expression of MYC protein]
CTD PMID:9808420 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Adenosine co-treated with Homocysteine] results in decreased expression of NFKBIA mRNA CTD PMID:24224954 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nos2 nitric oxide synthase 2, inducible decreases stability
multiple interactions
ISO Adenosine results in decreased stability of NOS2 mRNA
Adenosine inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Adenosine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]
CTD PMID:24878381 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nt5e 5' nucleotidase, ecto multiple interactions EXP [alpha,beta-methyleneadenosine 5'-diphosphate results in decreased activity of NT5E protein] inhibits the reaction [Oxygen deficiency results in increased abundance of Adenosine] CTD PMID:23437309 NCBI chr 9:88,327,609...88,372,089
Ensembl chr 9:88,327,197...88,372,092
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression ISO Adenosine results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
JBrowse link
G Prf1 perforin 1 (pore forming protein) multiple interactions EXP [Adenosine co-treated with Coformycin] results in decreased expression of PRF1 mRNA CTD PMID:11992407 NCBI chr10:61,297,751...61,304,684
Ensembl chr10:61,297,833...61,304,680
JBrowse link
G Ptgdr prostaglandin D receptor multiple interactions EXP [Prostaglandin D2 results in increased activity of PTGDR protein] which results in increased metabolism of Adenosine; [Prostaglandin D2 results in increased activity of PTGDR protein] which results in increased secretion of Adenosine CTD PMID:11562489 NCBI chr14:44,851,235...44,859,375
Ensembl chr14:44,851,235...44,859,375
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein affects the localization of RELA protein modified form]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of RELA protein] CTD PMID:24224954 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Ren1 renin 1 structural decreases secretion ISO Adenosine results in decreased secretion of REN protein CTD PMID:3044993 NCBI chr 1:133,350,674...133,360,320
Ensembl chr 1:133,350,510...133,360,325
JBrowse link
G Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 multiple interactions ISO [Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein CTD PMID:24224954 NCBI chr13:34,002,225...34,035,170
Ensembl chr13:34,002,363...34,037,147
JBrowse link
G Slc28a1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 affects transport
multiple interactions
ISO SLC28A1 protein affects the transport of Adenosine
Adenosine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]
CTD PMID:9124315 NCBI chr 7:81,113,269...81,170,416
Ensembl chr 7:81,114,799...81,170,416
JBrowse link
G Slc28a2 solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 increases transport ISO SLC28A2 protein results in increased transport of Adenosine CTD PMID:10087507 NCBI chr 2:122,426,357...122,461,152
Ensembl chr 2:122,426,477...122,461,137
JBrowse link
G Slc29a1 solute carrier family 29 (nucleoside transporters), member 1 multiple interactions
increases uptake
affects abundance
EXP
ISO
4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]; 4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; [4-nitrobenzylthioinosine results in decreased activity of SLC29A1 protein] inhibits the reaction [Oxygen deficiency results in increased abundance of Adenosine]; [SLC29A1 co-treated with Oxygen deficiency] affects the abundance of Adenosine; Dipyridamole inhibits the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Dipyridamole promotes the reaction [[SLC29A1 co-treated with Oxygen deficiency] affects the abundance of Adenosine]
SLC29A1 protein alternative form results in increased uptake of Adenosine; SLC29A1 protein results in increased uptake of Adenosine
cilostazol inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; draflazine inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Ethanol promotes the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]; Ethanol promotes the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Ticagrelor inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]
Adenosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]
SLC29A1 affects the abundance of Adenosine
CTD PMID:9353301, PMID:9396714, PMID:11179696, PMID:21283641, PMID:21872611, PMID:23437309, PMID:28041785 NCBI chr17:45,585,200...45,599,618
Ensembl chr17:45,585,200...45,599,606
JBrowse link
G Slc29a2 solute carrier family 29 (nucleoside transporters), member 2 increases uptake ISO SLC29A2 protein results in increased uptake of Adenosine CTD PMID:9396714 NCBI chr19:5,019,057...5,031,972
Ensembl chr19:5,023,860...5,031,972
JBrowse link
G Slc29a3 solute carrier family 29 (nucleoside transporters), member 3 affects transport ISO SLC29A3 protein affects the transport of Adenosine CTD PMID:19164483 NCBI chr10:60,712,072...60,752,849
Ensembl chr10:60,712,072...60,752,794
JBrowse link
G Slc5a5 solute carrier family 5 (sodium iodide symporter), member 5 increases expression ISO Adenosine results in increased expression of SLC5A5 mRNA; Adenosine results in increased expression of SLC5A5 protein CTD PMID:16954431 NCBI chr 8:70,882,885...70,892,785
Ensembl chr 8:70,882,889...70,892,757
JBrowse link
G Tlr4 toll-like receptor 4 increases expression
affects localization
multiple interactions
ISO Adenosine results in increased expression of TLR4 mRNA
Adenosine affects the localization of TLR4 protein
Adenosine promotes the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of TLR4 protein]
CTD PMID:21538184 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine inhibits the reaction [Adenosine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]; [Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein affects the localization of RELA protein modified form]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of RELA protein]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; [Adenosine co-treated with Homocysteine] results in increased susceptibility to TNF protein; Adenosine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF mRNA]; Adenosine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]; ZM 241385 inhibits the reaction [Adenosine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]
Adenosine results in decreased expression of TNF protein
CTD PMID:11023991, PMID:21538184, PMID:24224954 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 multiple interactions ISO [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; [Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 mRNA; [Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 protein CTD PMID:24224954 NCBI chr10:19,000,910...19,015,410
Ensembl chr10:19,000,910...19,015,657
JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 multiple interactions EXP [Adenosine co-treated with Coformycin] results in decreased expression of TNFSF10 mRNA CTD PMID:11992407 NCBI chr 3:27,317,077...27,339,665
Ensembl chr 3:27,317,028...27,342,427
JBrowse link
G Upp1 uridine phosphorylase 1 increases metabolic processing EXP UPP1 protein results in increased metabolism of Adenosine CTD PMID:15772079 NCBI chr11:9,118,008...9,136,170
Ensembl chr11:9,118,103...9,136,170
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
increases secretion
ISO Adenosine promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]
Adenosine results in increased expression of VEGFA mRNA
Adenosine results in increased secretion of VEGFA protein
CTD PMID:20067761 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
adenosine 3',5'-bismonophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sult1a1 sulfotransferase family 1A, phenol-preferring, member 1 multiple interactions ISO Glutathione Disulfide affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]; Glutathione Disulfide affects the reaction [Polychlorinated Biphenyls analog affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]]; Polychlorinated Biphenyls analog affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein] CTD PMID:21130751 NCBI chr 7:126,672,865...126,690,443
Ensembl chr 7:126,672,865...126,676,432
JBrowse link
G Sult1e1 sulfotransferase family 1E, member 1 multiple interactions ISO [2,2',4,4'-tetrabromodiphenyl ether metabolite co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein; [Estradiol co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein; [tetrabromobisphenol A co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein; Estradiol inhibits the reaction [[tetrabromobisphenol A co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein]; tetrabromobisphenol A inhibits the reaction [[Estradiol co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein] CTD PMID:23959441 NCBI chr 5:87,575,968...87,591,611
Ensembl chr 5:87,575,969...87,591,594
JBrowse link
G Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 affects binding
multiple interactions
ISO adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein
Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]; Dehydroepiandrosterone inhibits the reaction [Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]]
CTD PMID:24059442 NCBI chr 7:13,796,246...13,837,410
Ensembl chr 7:13,796,246...13,837,409
JBrowse link
adenosine 5'-(hexahydrogen pentaphosphate) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nudt10 nudix (nucleoside diphosphate linked moiety X)-type motif 10 multiple interactions ISO [NUDT11 protein results in increased metabolism of diadenosine 5',5''''-P1,P6-hexaphosphate] which results in increased chemical synthesis of adenosine 5'-pentaphosphate CTD PMID:12121577 NCBI chr  X:6,168,696...6,173,009
Ensembl chr  X:6,168,696...6,173,015
Ensembl chr  X:6,168,696...6,173,015
JBrowse link
adenosine 5'-[gamma-thio]triphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd80 CD80 antigen increases expression EXP adenosine 5'-O-(3-thiotriphosphate) results in increased expression of CD80 protein CTD PMID:15944274 NCBI chr16:38,457,430...38,495,958
Ensembl chr16:38,455,561...38,496,335
JBrowse link
G Cd86 CD86 antigen increases expression EXP adenosine 5'-O-(3-thiotriphosphate) results in increased expression of CD86 protein CTD PMID:15944274 NCBI chr16:36,568,956...36,666,158
Ensembl chr16:36,603,869...36,666,081
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO [adenosine 5'-O-(3-thiotriphosphate) binds to and results in increased activity of P2RY11 protein] which results in increased expression of CXCL8 protein CTD PMID:19815812 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Il10 interleukin 10 decreases expression EXP adenosine 5'-O-(3-thiotriphosphate) results in decreased expression of IL10 protein CTD PMID:15944274 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il12b interleukin 12b increases expression EXP adenosine 5'-O-(3-thiotriphosphate) results in increased expression of IL12B protein CTD PMID:15944274 NCBI chr11:44,400,063...44,414,677
Ensembl chr11:44,400,063...44,414,033
JBrowse link
G Il1b interleukin 1 beta increases expression EXP adenosine 5'-O-(3-thiotriphosphate) results in increased expression of IL1B protein CTD PMID:15944274 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 affects response to substance EXP P2RX7 protein affects the susceptibility to adenosine 5'-O-(3-thiotriphosphate) CTD PMID:12873706 NCBI chr 5:122,643,927...122,692,336
Ensembl chr 5:122,643,911...122,691,432
JBrowse link
G Ptgdr prostaglandin D receptor multiple interactions ISO adenosine 5'-O-(3-thiotriphosphate) inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] CTD PMID:9579725 NCBI chr14:44,851,235...44,859,375
Ensembl chr14:44,851,235...44,859,375
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity
multiple interactions
ISO adenosine 5'-O-(3-thiotriphosphate) results in increased activity of TRPV1 protein
Capsaicin promotes the reaction [adenosine 5'-O-(3-thiotriphosphate) results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [adenosine 5'-O-(3-thiotriphosphate) results in increased activity of TRPV1 protein]
CTD PMID:11140687 NCBI chr11:73,234,149...73,261,322
Ensembl chr11:73,234,292...73,261,242
JBrowse link
adenosine 5'-monophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 multiple interactions EXP Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]] CTD PMID:11390963 NCBI chr 6:142,587,862...142,702,766
Ensembl chr 6:142,587,862...142,702,315
JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 multiple interactions ISO [4-dimethylaminocinnamaldehyde co-treated with Adenosine Monophosphate] binds to ALDH1A1 protein CTD PMID:10609638 NCBI chr19:20,492,583...20,643,463
Ensembl chr19:20,492,715...20,643,465
JBrowse link
G Ercc6 excision repair cross-complementing rodent repair deficiency, complementation group 6 increases abundance EXP ERCC6 gene mutant form results in increased abundance of Adenosine Monophosphate CTD PMID:25440059 NCBI chr14:32,513,291...32,580,990
Ensembl chr14:32,513,521...32,580,990
JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 multiple interactions EXP Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]] CTD PMID:11390963 NCBI chr 7:46,097,123...46,100,952
Ensembl chr 7:46,093,953...46,100,764
JBrowse link
G Nudt10 nudix (nucleoside diphosphate linked moiety X)-type motif 10 multiple interactions ISO [NUDT11 protein results in increased metabolism of diadenosine 5',5''''-P1,P6-hexaphosphate] which results in increased chemical synthesis of Adenosine Monophosphate; [NUDT11 protein results in increased metabolism of P(1),P(5)-di(adenosine-5'-)pentaphosphate] which results in increased chemical synthesis of Adenosine Monophosphate CTD PMID:12121577 NCBI chr  X:6,168,696...6,173,009
Ensembl chr  X:6,168,696...6,173,015
Ensembl chr  X:6,168,696...6,173,015
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression ISO Adenosine Monophosphate results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
JBrowse link
G Trp73 transformation related protein 73 affects abundance EXP TP73 protein affects the abundance of Adenosine Monophosphate CTD PMID:25554796 NCBI chr 4:154,056,249...154,139,875
Ensembl chr 4:154,056,253...154,140,208
Ensembl chr 4:154,056,253...154,140,208
JBrowse link
ADP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 multiple interactions
affects binding
ISO estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein mutant form]; estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein]; Vanadates promotes the reaction [Adenosine Diphosphate binds to ABCC1 protein]
Adenosine Diphosphate binds to ABCC1 protein; Adenosine Diphosphate binds to ABCC1 protein mutant form
CTD PMID:18336795 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions ISO Adenosine Diphosphate affects the folding of [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:1848756 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Ak1 adenylate kinase 1 increases abundance EXP AK1 protein results in increased abundance of Adenosine Diphosphate CTD PMID:11390963 NCBI chr 2:32,621,758...32,635,058
Ensembl chr 2:32,621,758...32,635,058
JBrowse link
G Alb albumin decreases secretion
multiple interactions
ISO Adenosine Diphosphate results in decreased secretion of ALB protein
Aspirin inhibits the reaction [Adenosine Diphosphate results in decreased secretion of ALB protein]
CTD PMID:17303692 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
G Axl AXL receptor tyrosine kinase decreases response to substance ISO AXL protein results in decreased susceptibility to Adenosine Diphosphate CTD PMID:15733062 NCBI chr 7:25,756,500...25,788,924
Ensembl chr 7:25,757,273...25,788,705
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Adenosine Diphosphate results in increased glutathionylation of PTPN1 protein] CTD PMID:16781456 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cd40lg CD40 ligand increases expression
multiple interactions
ISO
EXP
Adenosine Diphosphate results in increased expression of CD40LG protein
clopidogrel inhibits the reaction [Adenosine Diphosphate results in increased expression of CD40LG protein]
CTD PMID:11297035, PMID:17043144 NCBI chr  X:57,212,143...57,224,042
Ensembl chr  X:57,212,143...57,224,042
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions ISO Adenosine Diphosphate binds to and results in decreased activity of CFTR protein; P(1),P(5)-di(adenosine-5'-)pentaphosphate inhibits the reaction [Adenosine Diphosphate binds to and results in decreased activity of CFTR protein] CTD PMID:15684079 NCBI chr 6:18,170,687...18,322,770
Ensembl chr 6:18,170,687...18,322,768
JBrowse link
G Chordc1 cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 multiple interactions EXP Adenosine Diphosphate binds to and affects the folding of CHORDC1 protein; Adenosine Diphosphate promotes the reaction [CHORDC1 protein binds to CHORDC1 protein]; Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to CHORDC1 protein] CTD PMID:23184943 NCBI chr 9:18,292,267...18,314,000
Ensembl chr 9:18,292,125...18,317,442
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 multiple interactions ISO CYP2C19 gene affects the susceptibility to [Adenosine Diphosphate co-treated with clopidogrel]; CYP2C19 gene SNP affects the reaction [Adenosine Diphosphate results in increased expression of SELP protein]; CYP2C19 gene SNP affects the susceptibility to [Adenosine Diphosphate co-treated with Arachidonic Acid] CTD PMID:16772608, PMID:18004210, PMID:18394438 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Dtymk deoxythymidylate kinase multiple interactions ISO DTYMK protein binds to [N1-(4-bis(pivaloyloxymethyl)phosphinylbuten-2-yl)thymine co-treated with Adenosine Diphosphate] CTD PMID:21128666 NCBI chr 1:93,792,576...93,802,068
Ensembl chr 1:93,792,576...93,801,934
JBrowse link
G Epha4 Eph receptor A4 increases phosphorylation
multiple interactions
ISO Adenosine Diphosphate results in increased phosphorylation of EPHA4 protein
Benzoic Acid analog inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of EPHA4 protein]
CTD PMID:22273509 NCBI chr 1:77,367,182...77,515,107
Ensembl chr 1:77,367,185...77,515,088
JBrowse link
G Ern1 endoplasmic reticulum (ER) to nucleus signalling 1 multiple interactions
decreases activity
EXP Adenosine Diphosphate inhibits the reaction [ERN1 protein binds to ERN1 protein]
Adenosine Diphosphate results in decreased activity of ERN1 protein
CTD PMID:25164867 NCBI chr11:106,397,620...106,487,796
Ensembl chr11:106,394,650...106,487,852
JBrowse link
G F2 coagulation factor II increases abundance
multiple interactions
ISO F2 protein results in increased abundance of Adenosine Diphosphate
Quercetin inhibits the reaction [F2 protein results in increased abundance of Adenosine Diphosphate]; resveratrol inhibits the reaction [F2 protein results in increased abundance of Adenosine Diphosphate]
CTD PMID:15342215 NCBI chr 2:91,612,397...91,636,457
Ensembl chr 2:91,625,320...91,636,414
JBrowse link
G Fga fibrinogen alpha chain multiple interactions
increases secretion
ISO Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGA protein] CTD PMID:17303692 NCBI chr 3:83,026,153...83,033,627
Ensembl chr 3:83,026,076...83,033,627
JBrowse link
G Fgb fibrinogen beta chain decreases secretion
multiple interactions
ISO Adenosine Diphosphate results in decreased secretion of FGB protein
Aspirin inhibits the reaction [Adenosine Diphosphate results in decreased secretion of FGB protein]
CTD PMID:17303692 NCBI chr 3:83,042,246...83,049,863
Ensembl chr 3:83,040,141...83,049,863
JBrowse link
G Fgg fibrinogen gamma chain increases secretion
multiple interactions
ISO Adenosine Diphosphate results in increased secretion of FGG protein
Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGG protein]
CTD PMID:17303692 NCBI chr 3:83,007,724...83,015,056
Ensembl chr 3:83,007,724...83,015,049
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO Adenosine Diphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog] CTD PMID:15788719 NCBI chr 6:125,161,852...125,166,467
Ensembl chr 6:125,161,715...125,166,467
JBrowse link
G Gas6 growth arrest specific 6 increases response to substance ISO GAS6 protein results in increased susceptibility to Adenosine Diphosphate CTD PMID:15733062 NCBI chr 8:13,465,374...13,494,535
Ensembl chr 8:13,465,374...13,494,490
JBrowse link
G Hras Harvey rat sarcoma virus oncogene multiple interactions ISO Adenosine Diphosphate binds to and affects the folding of HRAS protein CTD PMID:16388579 NCBI chr 7:141,189,934...141,194,019
Ensembl chr 7:141,189,105...141,194,005
JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 multiple interactions EXP Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]; Calcium promotes the reaction [Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]] CTD PMID:23184943 NCBI chr12:110,691,036...110,696,395
Ensembl chr12:110,690,605...110,702,728
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions
increases abundance
EXP Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Adenosine Diphosphate] CTD PMID:27469509 NCBI chr 7:80,094,845...80,118,608
Ensembl chr 7:80,094,846...80,115,392
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
EXP Adenosine Diphosphate results in increased expression of IL6 protein
MRS 2211 inhibits the reaction [Adenosine Diphosphate results in increased expression of IL6 protein]
CTD PMID:24849676 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Itga2 integrin alpha 2 multiple interactions ISO ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Adenosine Diphosphate] CTD PMID:16214444 NCBI chr13:114,833,081...114,932,100
Ensembl chr13:114,833,081...114,932,100
JBrowse link
G Itga2b integrin alpha 2b multiple interactions ISO cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]] CTD PMID:18404433 NCBI chr11:102,453,297...102,469,883
Ensembl chr11:102,453,297...102,470,122
JBrowse link
G Itgb1bp2 integrin beta 1 binding protein 2 multiple interactions EXP Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to CHORDC1 protein]; Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]; Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to ITGB1BP2 protein]; Calcium promotes the reaction [Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]] CTD PMID:23184943 NCBI chr  X:101,449,088...101,466,122
Ensembl chr  X:101,449,088...101,453,541
JBrowse link
G Itgb3 integrin beta 3 multiple interactions ISO cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]] CTD PMID:18404433 NCBI chr11:104,608,000...104,670,476
Ensembl chr11:104,608,000...104,670,476
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation ISO Adenosine Diphosphate results in increased phosphorylation of MAPK1 protein CTD PMID:15034929 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation ISO Adenosine Diphosphate results in increased phosphorylation of MAPK3 protein CTD PMID:15034929 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Dicumarol inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of MAPK8 protein] CTD PMID:24466103 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Dicumarol inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of MAPK9 protein] CTD PMID:24466103 NCBI chr11:49,846,728...49,886,421
Ensembl chr11:49,846,751...49,886,421
JBrowse link
G Mertk MER proto-oncogene tyrosine kinase increases response to substance ISO MERTK protein results in increased susceptibility to Adenosine Diphosphate CTD PMID:15733062 NCBI chr 2:128,698,915...128,803,162
Ensembl chr 2:128,698,956...128,802,894
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Adenosine Diphosphate] CTD PMID:11498454 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nt5e 5' nucleotidase, ecto decreases activity ISO Adenosine Diphosphate analog results in decreased activity of NT5E protein CTD PMID:18404487 NCBI chr 9:88,327,609...88,372,089
Ensembl chr 9:88,327,197...88,372,092
JBrowse link
G P2ry12 purinergic receptor P2Y, G-protein coupled 12 affects response to substance
increases response to substance
multiple interactions
ISO
EXP
P2RY12 gene polymorphism affects the susceptibility to Adenosine Diphosphate; P2RY12 protein affects the susceptibility to Adenosine Diphosphate
P2RY12 protein results in increased susceptibility to Adenosine Diphosphate
Epinephrine inhibits the reaction [P2RY12 gene mutant form results in decreased susceptibility to Adenosine Diphosphate]
P2RY12 protein affects the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]
CTD PMID:11196645, PMID:11413167, PMID:18404433, PMID:23849096 NCBI chr 3:59,216,271...59,262,985
Ensembl chr 3:59,216,272...59,262,871
JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide increases secretion
multiple interactions
ISO Adenosine Diphosphate results in increased secretion of PDGFB protein
Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of PDGFB protein]
CTD PMID:17303692 NCBI chr15:79,995,865...80,024,614
Ensembl chr15:79,995,874...80,014,977
JBrowse link
G Pf4 platelet factor 4 increases secretion ISO Adenosine Diphosphate results in increased secretion of PF4 protein CTD PMID:19428933 NCBI chr 5:90,772,435...90,773,383
Ensembl chr 5:90,772,435...90,773,383
JBrowse link
G Pfkm phosphofructokinase, muscle multiple interactions ISO Adenosine Diphosphate inhibits the reaction [resveratrol results in decreased activity of PFKM protein] CTD PMID:23454376 NCBI chr15:98,092,589...98,132,447
Ensembl chr15:98,092,589...98,132,451
JBrowse link
G Pgp phosphoglycolate phosphatase decreases phosphorylation EXP PGP protein results in decreased phosphorylation of Adenosine Diphosphate CTD PMID:24338473 NCBI chr17:24,470,426...24,473,110
Ensembl chr17:24,470,392...24,473,110
JBrowse link
G Ppbp pro-platelet basic protein increases secretion ISO Adenosine Diphosphate results in increased secretion of PPBP protein CTD PMID:19428933 NCBI chr 5:90,768,518...90,770,063
Ensembl chr 5:90,768,518...90,770,063
JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit multiple interactions ISO Adenosine Diphosphate binds to and affects the folding of PPP5C protein CTD PMID:23184943 NCBI chr 7:17,004,640...17,027,914
Ensembl chr 7:17,004,640...17,027,924
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 increases glutathionylation
multiple interactions
ISO Adenosine Diphosphate results in increased glutathionylation of PTPN1 protein
CAT protein inhibits the reaction [Adenosine Diphosphate results in increased glutathionylation of PTPN1 protein]
CTD PMID:16781456 NCBI chr 2:167,930,750...167,979,385
Ensembl chr 2:167,932,057...167,979,385
JBrowse link
G Selp selectin, platelet multiple interactions
increases expression
ISO cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]; CYP2C19 gene SNP affects the reaction [Adenosine Diphosphate results in increased expression of SELP protein]; Heparin promotes the reaction [Adenosine Diphosphate affects the localization of SELP protein]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]]; P2RY12 protein affects the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]; Quercetin inhibits the reaction [Adenosine Diphosphate results in increased expression of SELP protein] CTD PMID:9740346, PMID:18394438, PMID:18404433, PMID:23249183 NCBI chr 1:164,115,264...164,150,026
Ensembl chr 1:164,115,264...164,150,026
JBrowse link
G Sirt3 sirtuin 3 decreases abundance EXP SIRT3 protein results in decreased abundance of Adenosine Diphosphate CTD PMID:23166782 NCBI chr 7:140,863,663...140,882,309
Ensembl chr 7:140,863,666...140,882,309
JBrowse link
G Taldo1 transaldolase 1 increases abundance EXP TALDO1 gene mutant form results in increased abundance of Adenosine Diphosphate CTD PMID:19436114 NCBI chr 7:141,392,160...141,402,976
Ensembl chr 7:141,392,199...141,402,968
JBrowse link
G Thbs1 thrombospondin 1 increases secretion ISO Adenosine Diphosphate results in increased secretion of THBS1 protein CTD PMID:17303692 NCBI chr 2:118,111,876...118,127,133
Ensembl chr 2:118,111,876...118,127,133
JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase 3 increases response to substance ISO TYRO3 protein results in increased susceptibility to Adenosine Diphosphate CTD PMID:15733062 NCBI chr 2:119,797,740...119,818,104
Ensembl chr 2:119,797,733...119,818,104
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions
increases phosphorylation
ISO N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of VASP protein] CTD PMID:25329809 NCBI chr 7:19,256,929...19,271,854
Ensembl chr 7:19,256,929...19,271,817
JBrowse link
ADP-D-ribose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adprh ADP-ribosylarginine hydrolase increases hydrolysis ISO ADPRH protein results in increased hydrolysis of Adenosine Diphosphate Ribose metabolite CTD PMID:21498885 NCBI chr16:38,445,399...38,452,689
Ensembl chr16:38,444,030...38,452,703
JBrowse link
G Adprs ADP-ribosylserine hydrolase increases hydrolysis
multiple interactions
ISO ADPRS protein results in increased hydrolysis of Adenosine Diphosphate Ribose metabolite
Adenosine Diphosphate Ribose inhibits the reaction [ADPRS protein results in increased hydrolysis of O-Acetyl-ADP-Ribose]
CTD PMID:21498885 NCBI chr 4:126,316,351...126,321,703
Ensembl chr 4:126,316,047...126,321,703
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions EXP NOS1 protein affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased ribosylation of Adenosine Diphosphate Ribose] CTD PMID:10318960 NCBI chr 5:117,866,839...117,958,840
Ensembl chr 5:117,781,032...117,958,840
JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 multiple interactions
increases activity
ISO
EXP
Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]; Clotrimazole inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]; Flufenamic Acid inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]
Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein
2-aminoethoxydiphenyl borate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Copper Sulfate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; ferrous chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; lead nitrate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Mercuric Chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Miconazole inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Selenium Oxides inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]
TRPM2 protein promotes the reaction [Adenosine Diphosphate Ribose results in increased uptake of Calcium]
CTD PMID:18204483, PMID:20878536, PMID:21900507, PMID:22750002 NCBI chr10:77,907,722...77,969,909
Ensembl chr10:77,907,722...77,970,563
JBrowse link
alprenolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenergic receptor, beta 1 multiple interactions
increases phosphorylation
increases activity
ISO [Alprenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Alprenolol binds to and results in decreased activity of ADRB1 protein; Alprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Alprenolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; Alprenolol promotes the reaction [ADRB1 protein binds to ARRB1 protein]; Alprenolol promotes the reaction [ADRB1 protein binds to ARRB2 protein]; Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; CGP 20712A affects the reaction [Alprenolol results in increased activity of ADRB1 protein]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]
[Alprenolol results in increased phosphorylation of ADRB1 protein] which results in increased phosphorylation of EGFR protein; Alprenolol results in increased phosphorylation of ADRB1 protein
CTD PMID:12761341, PMID:14730417, PMID:15060759, PMID:18787115 NCBI chr19:56,722,117...56,725,150
Ensembl chr19:56,722,199...56,733,113
JBrowse link
G Adrb2 adrenergic receptor, beta 2 multiple interactions ISO
EXP
[Alprenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Alprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Alprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Alprenolol co-treated with ADRB2 protein] results in increased expression of GNAS protein; Alprenolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]
Alprenolol inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]; Alprenolol inhibits the reaction [ADRB2 results in increased expression of GRK2 protein]
CTD PMID:10455254, PMID:12198331, PMID:14730417, PMID:17925438 NCBI chr18:62,177,713...62,179,981
Ensembl chr18:62,177,816...62,179,959
JBrowse link
G Adrb3 adrenergic receptor, beta 3 multiple interactions ISO [Alprenolol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Alprenolol binds to and results in increased activity of ADRB3 protein; Alprenolol inhibits the reaction [cyanopindolol binds to ADRB3 protein] CTD PMID:14730417 NCBI chr 8:27,225,776...27,230,845
Ensembl chr 8:27,225,776...27,250,616
JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions ISO [Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR125A mRNA; [Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR125B-1 mRNA; [Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR150 mRNA; [Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR214 mRNA; Alprenolol promotes the reaction [ADRB1 protein binds to ARRB1 protein]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]] CTD PMID:18787115, PMID:24334028 NCBI chr 7:99,535,147...99,606,772
Ensembl chr 7:99,535,466...99,606,771
JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions ISO Alprenolol promotes the reaction [ADRB1 protein binds to ARRB2 protein]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]] CTD PMID:18787115 NCBI chr11:70,432,485...70,440,828
Ensembl chr11:70,432,635...70,440,828
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation
ISO AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]
[Alprenolol results in increased phosphorylation of ADRB1 protein] which results in increased phosphorylation of EGFR protein
CTD PMID:18787115 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus multiple interactions ISO [Alprenolol co-treated with ADRB2 protein] results in increased expression of GNAS protein CTD PMID:10455254 NCBI chr 2:174,284,320...174,346,744
Ensembl chr 2:174,284,320...174,346,744
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 multiple interactions EXP Alprenolol inhibits the reaction [ADRB2 results in increased expression of GRK2 protein] CTD PMID:12198331 NCBI chr19:4,285,999...4,306,222
Ensembl chr19:4,286,001...4,306,222
JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]] CTD PMID:18787115 NCBI chr18:36,504,927...36,515,805
Ensembl chr18:36,504,927...36,515,805
JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A multiple interactions EXP [Alprenolol co-treated with Cocaine] affects the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] CTD PMID:8392199 NCBI chr14:74,640,874...74,706,859
Ensembl chr14:74,640,840...74,709,494
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
[Alprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]
Erlotinib Hydrochloride inhibits the reaction [Alprenolol results in increased phosphorylation of MAPK1 protein]
CTD PMID:17925438, PMID:18787115 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
[Alprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]
Erlotinib Hydrochloride inhibits the reaction [Alprenolol results in increased phosphorylation of MAPK3 protein]
CTD PMID:17925438, PMID:18787115 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mir125a microRNA 125a increases expression
multiple interactions
EXP
ISO
Alprenolol results in increased expression of MIR125A mRNA
[Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR125A mRNA
CTD PMID:24334028 NCBI chr17:17,830,812...17,830,879
Ensembl chr17:17,830,812...17,830,879
JBrowse link
G Mir125b-1 microRNA 125b-1 increases expression
multiple interactions
EXP
ISO
Alprenolol results in increased expression of MIR125B-1 mRNA
[Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR125B-1 mRNA
CTD PMID:24334028 NCBI chr 9:41,581,926...41,582,002
Ensembl chr 9:41,581,926...41,582,002
JBrowse link
G Mir150 microRNA 150 multiple interactions
increases expression
ISO
EXP
[Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR150 mRNA
Alprenolol results in increased expression of MIR150 mRNA
CTD PMID:24334028 NCBI chr 7:45,121,757...45,121,821
Ensembl chr 7:45,121,757...45,121,821
JBrowse link
G Mir214 microRNA 214 increases expression
multiple interactions
EXP
ISO
Alprenolol results in increased expression of MIR214 mRNA
[Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR214 mRNA
CTD PMID:24334028 NCBI chr 1:162,223,368...162,223,477
Ensembl chr 1:162,223,368...162,223,477
JBrowse link
G Nppa natriuretic peptide type A increases expression EXP Alprenolol results in increased expression of NPPA mRNA CTD PMID:12721106 NCBI chr 4:148,000,722...148,002,074
Ensembl chr 4:148,000,722...148,002,079
JBrowse link
G Odc1 ornithine decarboxylase, structural 1 multiple interactions EXP Alprenolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein] CTD PMID:10353628 NCBI chr12:17,544,808...17,551,502
Ensembl chr12:17,544,794...17,551,505
JBrowse link
G Ren1 renin 1 structural multiple interactions
decreases expression
ISO Alprenolol inhibits the reaction [Hydralazine results in increased expression of REN protein]
Alprenolol results in decreased expression of REN protein
CTD PMID:923630 NCBI chr 1:133,350,674...133,360,320
Ensembl chr 1:133,350,510...133,360,325
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Alprenolol inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,584,189...12,628,489
Ensembl chr17:12,584,132...12,628,488
JBrowse link
AMP-PNP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions ISO Adenylyl Imidodiphosphate affects the folding of [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:1848756 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator affects activity ISO Adenylyl Imidodiphosphate affects the activity of CFTR protein CTD PMID:15657297 NCBI chr 6:18,170,687...18,322,770
Ensembl chr 6:18,170,687...18,322,768
JBrowse link
G Ptgdr prostaglandin D receptor multiple interactions ISO Adenylyl Imidodiphosphate inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] CTD PMID:9579725 NCBI chr14:44,851,235...44,859,375
Ensembl chr14:44,851,235...44,859,375
JBrowse link
arachidonoyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO arachidonyl-coenzyme A binds to and results in increased activity of PPARA protein CTD PMID:11139385 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
atenolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 multiple interactions
decreases activity
ISO Atenolol inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atenolol results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616
JBrowse link
G Adra2a adrenergic receptor, alpha 2a affects response to substance ISO ADRA2A gene SNP affects the susceptibility to Atenolol CTD PMID:15614026 NCBI chr19:54,045,259...54,048,982
Ensembl chr19:54,044,151...54,048,982
JBrowse link
G Adrb1 adrenergic receptor, beta 1 decreases activity
multiple interactions
affects binding
affects response to substance
decreases expression
ISO Atenolol results in decreased activity of ADRB1 protein
Atenolol binds to and results in decreased activity of ADRB1 protein; Atenolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Atenolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]
Atenolol binds to ADRB1 protein
[Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; [Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased susceptibility to Nicotine; [Atenolol co-treated with ADRB1] results in increased abundance of Cyclic AMP; Atenolol binds to and results in decreased activity of ADRB1 protein; Atenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [CGP 12177 results in increased activity of ADRB1 protein]; Atenolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Atenolol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]
ADRB1 protein polymorphism affects the susceptibility to Atenolol
Atenolol results in decreased expression of ADRB1 mRNA
CTD PMID:1389726, PMID:2462161, PMID:2897299, PMID:8102213, PMID:8386603, PMID:9593075, PMID:10372227, PMID:10894789, PMID:11425575, PMID:11483288, PMID:12022239, PMID:12761341, PMID:14730417, PMID:15060759, PMID:17003101, PMID:17369603, PMID:17628611, PMID:22192668 NCBI chr19:56,722,117...56,725,150
Ensembl chr19:56,722,199...56,733,113
JBrowse link
G Adrb2 adrenergic receptor, beta 2 increases expression
affects binding
multiple interactions
ISO Atenolol results in increased expression of ADRB2 protein
Atenolol binds to ADRB2 protein
Atenolol binds to and results in decreased activity of ADRB2 protein; Atenolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Atenolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]
[Atenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Atenolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; Atenolol binds to and results in decreased activity of ADRB2 protein; Atenolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]; Atenolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Atenolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; Atenolol inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; Atenolol inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]
CTD PMID:2462161, PMID:6093157, PMID:9593075, PMID:11425575, PMID:11483288, PMID:12920204, PMID:14730417, PMID:17925438 NCBI chr18:62,177,713...62,179,981
Ensembl chr18:62,177,816...62,179,959
JBrowse link
G Adrb3 adrenergic receptor, beta 3 multiple interactions ISO Atenolol inhibits the reaction [cyanopindolol binds to ADRB3 protein] CTD PMID:14730417 NCBI chr 8:27,225,776...27,230,845
Ensembl chr 8:27,225,776...27,250,616
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) affects response to substance
decreases expression
ISO AGT gene SNP affects the susceptibility to Atenolol
Atenolol results in decreased expression of AGT protein
CTD PMID:14639093, PMID:14700505 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Apoa1 apolipoprotein A-I decreases expression ISO Atenolol results in decreased expression of APOA1 protein CTD PMID:2193493 NCBI chr 9:46,228,630...46,230,469
Ensembl chr 9:46,228,580...46,230,466
JBrowse link
G Apoa2 apolipoprotein A-II decreases expression ISO Atenolol results in decreased expression of APOA2 protein CTD PMID:2193493 NCBI chr 1:171,221,564...171,226,379
Ensembl chr 1:171,225,054...171,226,379
JBrowse link
G Apob apolipoprotein B increases expression ISO Atenolol results in increased expression of APOB; Atenolol results in increased expression of APOB protein CTD PMID:1928808, PMID:2193493 NCBI chr12:7,977,629...8,016,839
Ensembl chr12:7,977,648...8,016,835
JBrowse link
G Atf1 activating transcription factor 1 multiple interactions ISO Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of ATF1 protein] CTD PMID:16671086 NCBI chr15:100,227,859...100,261,248
Ensembl chr15:100,227,819...100,261,244
JBrowse link
G B2m beta-2 microglobulin decreases expression ISO Atenolol results in decreased expression of B2M protein CTD PMID:2656332 NCBI chr 2:122,147,687...122,153,082
Ensembl chr 2:122,147,686...122,153,083
JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 affects response to substance ISO BDKRB2 exon polymorphism affects the susceptibility to Atenolol CTD PMID:12640257 NCBI chr12:105,563,172...105,595,244
Ensembl chr12:105,563,226...105,595,237
JBrowse link
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit increases response to substance ISO CACNA1C gene polymorphism results in increased susceptibility to Atenolol CTD PMID:20031608 NCBI chr 6:118,587,240...119,197,384
Ensembl chr 6:118,587,240...119,196,890
Ensembl chr 6:118,587,240...119,196,890
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Atenolol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein] CTD PMID:10728402 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cat catalase multiple interactions ISO Atenolol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Atenolol promotes the reaction [Quercetin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]]; Atenolol promotes the reaction [Thyroxine results in decreased expression of CAT protein]; Quercetin promotes the reaction [Atenolol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]] CTD PMID:2575990, PMID:22391854 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions EXP Atenolol inhibits the reaction [Isoproterenol results in increased expression of CDK1 mRNA] CTD PMID:9593584 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938
JBrowse link
G Clec2h C-type lectin domain family 2, member h increases expression ISO Atenolol results in increased expression of CLEC2B mRNA CTD PMID:19915711 NCBI chr 6:128,662,385...128,677,374
Ensembl chr 6:128,662,385...128,677,374
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of CREB1 protein] CTD PMID:16671086 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Edn1 endothelin 1 affects response to substance ISO EDN1 gene polymorphism affects the susceptibility to Atenolol CTD PMID:15188945 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of EGFR protein] CTD PMID:16671086 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) multiple interactions ISO Atenolol inhibits the reaction [Epinephrine results in increased expression of FAS protein] CTD PMID:10728402 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) multiple interactions ISO Atenolol inhibits the reaction [Epinephrine results in increased expression of FASLG protein] CTD PMID:10728402 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fkbp1b FK506 binding protein 1b multiple interactions ISO Atenolol promotes the reaction [FKBP1B protein binds to RYR2 protein] CTD PMID:12743001 NCBI chr12:4,833,176...4,841,573
Ensembl chr12:4,833,174...4,841,591
JBrowse link
G Fkbp5 FK506 binding protein 5 decreases expression ISO Atenolol results in decreased expression of FKBP5 mRNA CTD PMID:19915711 NCBI chr17:28,398,753...28,486,149
Ensembl chr17:28,399,094...28,517,527
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked multiple interactions ISO Atenolol inhibits the reaction [Dopamine results in increased activity of G6PD protein]; Atenolol inhibits the reaction [Isoproterenol results in increased activity of G6PD protein] CTD PMID:1978808 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression ISO Atenolol results in increased expression of GJA1 protein CTD PMID:16448880 NCBI chr10:56,377,300...56,390,419
Ensembl chr10:56,377,330...56,402,513
JBrowse link
G Gja4 gap junction protein, alpha 4 increases expression ISO Atenolol results in increased expression of GJA4 protein CTD PMID:16448880 NCBI chr 4:127,311,420...127,314,039
Ensembl chr 4:127,311,421...127,314,039
JBrowse link
G Gm26079 predicted gene, 26079 increases expression ISO Atenolol results in increased expression of SNORA49 mRNA CTD PMID:19915711 NCBI chr 5:110,692,049...110,692,181
Ensembl chr 5:110,692,049...110,692,181
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 decreases expression EXP Atenolol results in decreased expression of GRK2 mRNA; Atenolol results in decreased expression of GRK2 protein CTD PMID:9788834 NCBI chr19:4,285,999...4,306,222
Ensembl chr19:4,286,001...4,306,222
JBrowse link
G Ins2 insulin II multiple interactions ISO Atenolol inhibits the reaction [Terbutaline results in increased expression of INS protein] CTD PMID:12795776 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381
JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 affects response to substance ISO KCNJ2 gene affects the susceptibility to Atenolol CTD PMID:15028050 NCBI chr11:111,066,164...111,076,825
Ensembl chr11:111,066,164...111,076,821
JBrowse link
G Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 affects response to substance ISO KCNQ1 gene affects the susceptibility to Atenolol CTD PMID:15028050 NCBI chr 7:143,106,877...143,427,050
Ensembl chr 7:143,106,362...143,427,042
JBrowse link
G Lipc lipase, hepatic multiple interactions ISO LIPC gene SNP affects the susceptibility to and affects the metabolism of Atenolol CTD PMID:23536766 NCBI chr 9:70,798,128...70,952,221
Ensembl chr 9:70,798,128...70,952,226
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK1 protein] CTD PMID:16671086, PMID:17003101, PMID:17925438 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK3 protein] CTD PMID:16671086, PMID:17003101, PMID:17925438 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP Atenolol inhibits the reaction [carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [carvedilol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Atenolol inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Dopamine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:19439816 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nppa natriuretic peptide type A decreases expression ISO Atenolol results in decreased expression of NPPA protein CTD PMID:12866806 NCBI chr 4:148,000,722...148,002,074
Ensembl chr 4:148,000,722...148,002,079
JBrowse link
G Nppb natriuretic peptide type B multiple interactions
decreases expression
increases expression
ISO [Atenolol co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Atenolol co-treated with Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA
Atenolol results in decreased expression of NPPB mRNA
Atenolol results in increased expression of NPPB protein
CTD PMID:15969258, PMID:18192850 NCBI chr 4:147,985,786...147,987,205
Ensembl chr 4:147,985,788...147,987,205
JBrowse link
G Pla2g4c phospholipase A2, group IVC (cytosolic, calcium-independent) multiple interactions ISO PLA2G4C gene SNP affects the susceptibility to and affects the metabolism of Atenolol CTD PMID:23536766 NCBI chr 7:13,311,507...13,360,674
Ensembl chr 7:13,324,655...13,360,672
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein] CTD PMID:17003101 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 multiple interactions ISO Atenolol inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein] CTD PMID:17623046 NCBI chr 7:47,077,795...47,134,026
Ensembl chr 7:47,077,795...47,133,684
JBrowse link
G Ren1 renin 1 structural multiple interactions
decreases expression
decreases activity
ISO [aliskiren co-treated with Atenolol] results in decreased activity of REN protein; [Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein
Atenolol results in decreased expression of REN protein
Atenolol inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of REN protein]; Atenolol inhibits the reaction [2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein]
Atenolol results in decreased activity of REN protein
CTD PMID:3142437, PMID:3333524, PMID:9300315, PMID:14639093, PMID:18957387 NCBI chr 1:133,350,674...133,360,320
Ensembl chr 1:133,350,510...133,360,325
JBrowse link
G Ryr2 ryanodine receptor 2, cardiac increases activity
multiple interactions
ISO Atenolol results in increased activity of RYR2 protein
Atenolol promotes the reaction [FKBP1B protein binds to RYR2 protein]
CTD PMID:12743001 NCBI chr13:11,553,099...12,106,945
Ensembl chr13:11,553,102...12,106,945
JBrowse link
G Slc19a1 solute carrier family 19 (folate transporter), member 1 decreases expression ISO Atenolol results in decreased expression of SLC19A1 mRNA CTD PMID:19616087 NCBI chr10:77,032,269...77,050,432
Ensembl chr10:77,032,241...77,061,002
JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 multiple interactions ISO Atenolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr17:12,648,874...12,675,838
Ensembl chr17:12,648,869...12,675,829
JBrowse link
G Slc6a8 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 decreases expression ISO Atenolol results in decreased expression of SLC6A8 mRNA CTD PMID:19915711 NCBI chr  X:73,673,133...73,682,502
Ensembl chr  X:73,673,150...73,682,502
JBrowse link
G Slco4c1 solute carrier organic anion transporter family, member 4C1 increases expression ISO Atenolol results in increased expression of SLCO4C1 mRNA CTD PMID:19915711 NCBI chr 1:96,816,270...96,872,193
Ensembl chr 1:96,816,270...96,872,171
JBrowse link
G Snrpn small nuclear ribonucleoprotein N increases expression ISO Atenolol results in increased expression of SNRPN mRNA CTD PMID:19915711 NCBI chr 7:59,982,495...60,450,177
Ensembl chr 7:59,982,495...60,140,219
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]
Atenolol promotes the reaction [Thyroxine results in decreased expression of SOD1 protein]
CTD PMID:2575990, PMID:11163531 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]
Atenolol inhibits the reaction [Thyroxine results in increased expression of SOD2 protein]
CTD PMID:2575990, PMID:11163531 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 decreases response to substance EXP TRPA1 gene mutant form results in decreased susceptibility to Atenolol CTD PMID:29627347 NCBI chr 1:14,872,644...14,918,862
Ensembl chr 1:14,872,648...14,918,862
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Atenolol results in increased expression of TXN mRNA CTD PMID:19915711 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
ATP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8b ATP-binding cassette, sub-family A (ABC1), member 8b multiple interactions ISO Adenosine Triphosphate affects the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:12379217 NCBI chr11:109,932,206...109,996,274
Ensembl chr11:109,932,190...109,995,845
JBrowse link
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 multiple interactions ISO Adenosine Triphosphate promotes the reaction [ABCB11 protein results in increased uptake of fexofenadine] CTD PMID:18245269 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A multiple interactions
increases hydrolysis
ISO [Cobalt results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate; [Magnesium results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate; [Manganese results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate; ABCB1 protein binds to and results in increased hydrolysis of Adenosine Triphosphate; aurapten promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; crizotinib promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram affects the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; lapatinib promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; nobiletin promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]
[Rifampin metabolite results in decreased activity of ABCB1A protein] which results in decreased abundance of Adenosine Triphosphate
CTD PMID:2900677, PMID:14978246, PMID:18829547, PMID:18955043, PMID:22233293, PMID:23685082 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 multiple interactions
affects activity
increases hydrolysis
affects binding
ISO
EXP
[Adenosine Triphosphate affects the activity of ABCC1 protein] which results in increased transport of Acetaminophen metabolite; ABCC1 protein binds to and results in increased degradation of Adenosine Triphosphate; ABCC1 protein binds to and results in increased hydrolysis of Adenosine Triphosphate; ABCC1 protein mutant form binds to and results in increased hydrolysis of Adenosine Triphosphate; Adenosine Triphosphate binds to and affects the folding of ABCC1 protein; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of estradiol-17 beta-glucuronide]; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Leukotriene C4]; daidzein promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; hesperetin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; naringenin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; nobiletin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Quercetin affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Resveratrol promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Silymarin inhibits the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
Daunorubicin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Vanadates inhibits the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
Adenosine Triphosphate binds to ABCC1 protein
CTD PMID:10856430, PMID:11278000, PMID:14978246, PMID:15245331, PMID:15355964, PMID:15459206, PMID:15737336, PMID:15838832, PMID:16156793, PMID:18336795, PMID:18955043, PMID:32472168 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 multiple interactions
affects activity
affects metabolic processing
ISO
EXP
Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased secretion of Fluo-3]; Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased transport of temocaprilat]
Adenosine Triphosphate affects the activity of ABCC2 protein
[Adenosine Triphosphate affects the activity of ABCC2 protein] which results in increased transport of Acetaminophen metabolite; [Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; Adenosine Triphosphate affects the reaction [ABCC2 protein results in increased transport of Mercury]; verlukast inhibits the reaction [[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide]
ABCC2 protein affects the metabolism of Adenosine Triphosphate
Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased transport of S-1,2-dichlorovinyl-N-acetylcysteine]
CTD PMID:9067317, PMID:9794919, PMID:20060011, PMID:22027652, PMID:24039982, PMID:32003934, PMID:32472168 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 multiple interactions EXP Adenosine Triphosphate promotes the reaction [ABCC3 protein affects the transport of fexofenadine] CTD PMID:18245269 NCBI chr11:94,343,295...94,393,017
Ensembl chr11:94,343,295...94,392,997
JBrowse link
G Abcc4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 multiple interactions
affects activity
increases hydrolysis
ISO [Adenosine Triphosphate affects the activity of ABCC4 protein] which results in increased transport of Acetaminophen metabolite; ABCC4 protein binds to and results in increased hydrolysis of Adenosine Triphosphate; daidzein promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram inhibits the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; hesperetin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; naringenin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Quercetin affects the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Quercetin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]]; Resveratrol promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Silymarin inhibits the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Silymarin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]] CTD PMID:14978246, PMID:16156793, PMID:32472168 NCBI chr14:118,482,692...118,707,856
Ensembl chr14:118,482,692...118,706,219
JBrowse link
G Abcc6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 affects binding ISO Adenosine Triphosphate binds to ABCC6 protein CTD PMID:11880368 NCBI chr 7:45,974,110...46,030,491
Ensembl chr 7:45,967,555...46,030,302
JBrowse link
G Abcc8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 multiple interactions ISO Adenosine Triphosphate deficiency inhibits the reaction [Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]] CTD PMID:19095654 NCBI chr 7:46,104,523...46,180,039
Ensembl chr 7:46,104,523...46,180,033
JBrowse link
G Abcc9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 multiple interactions ISO
EXP
Adenosine Triphosphate results in decreased activity of [KCNJ8 protein binds to ABCC9 protein]
Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]]
CTD PMID:11390963, PMID:28842488 NCBI chr 6:142,587,862...142,702,766
Ensembl chr 6:142,587,862...142,702,315
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) increases hydrolysis
multiple interactions
ISO ABCG2 protein results in increased hydrolysis of Adenosine Triphosphate
[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate; Lapatinib promotes the reaction [ABCG2 protein results in increased hydrolysis of Adenosine Triphosphate]; Sulfasalazine inhibits the reaction [[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate]
CTD PMID:18829547, PMID:32003934 NCBI chr 6:58,584,491...58,692,451
Ensembl chr 6:58,584,523...58,695,676
JBrowse link
G Abl1 c-abl oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein; sorafenib inhibits the reaction [[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein] CTD PMID:19366808 NCBI chr 2:31,688,244...31,807,093
Ensembl chr 2:31,688,376...31,804,227
JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 increases secretion ISO ADCYAP1 protein results in increased secretion of Adenosine Triphosphate CTD PMID:18563302 NCBI chr17:93,198,245...93,206,541
Ensembl chr17:93,199,017...93,206,537
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression
multiple interactions
ISO Adenosine Triphosphate results in decreased expression of AGTR1A mRNA
Adenosine Triphosphate results in decreased expression of and results in decreased activity of AGTR1A protein; ARRB2 protein affects the reaction [Adenosine Triphosphate results in decreased activity of AGTR1A protein]; CABIN1 protein inhibits the reaction [Adenosine Triphosphate results in decreased expression of and results in decreased activity of AGTR1A protein]; Cyclosporine inhibits the reaction [Adenosine Triphosphate results in decreased expression of AGTR1A mRNA]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Adenosine Triphosphate results in decreased expression of AGTR1A mRNA]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Adenosine Triphosphate results in decreased expression of AGTR1A protein]
CTD PMID:21464294 NCBI chr13:30,336,356...30,382,867
Ensembl chr13:30,336,441...30,382,867
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions ISO Adenosine Triphosphate affects the folding of [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:1848756 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 decreases activity
multiple interactions
ISO Adenosine Triphosphate results in decreased activity of AKT1 protein
Alcohols inhibits the reaction [Adenosine Triphosphate results in decreased activity of AKT1 protein]
CTD PMID:24300283 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Aldh5a1 aldhehyde dehydrogenase family 5, subfamily A1 increases abundance EXP ALDH5A1 gene mutant form results in increased abundance of Adenosine Triphosphate CTD PMID:29031482 NCBI chr13:24,907,579...24,937,661
Ensembl chr13:24,907,579...24,937,661
JBrowse link
G Alk anaplastic lymphoma kinase affects binding
multiple interactions
ISO ALK protein binds to Adenosine Triphosphate
[ALK protein mutant form promotes the reaction [ALK protein binds to Adenosine Triphosphate]] which results in decreased susceptibility to crizotinib; ALK protein mutant form promotes the reaction [ALK protein binds to Adenosine Triphosphate]
CTD PMID:22072639 NCBI chr17:71,868,988...72,604,702
Ensembl chr17:71,868,972...72,604,627
JBrowse link
G Alpl alkaline phosphatase, liver/bone/kidney multiple interactions
increases response to substance
EXP ALPL gene mutant form promotes the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]
ALPL gene mutant form results in increased susceptibility to Adenosine Triphosphate
CTD PMID:27466191 NCBI chr 4:137,741,731...137,796,384
Ensembl chr 4:137,741,733...137,796,384
JBrowse link
G Anxa1 annexin A1 multiple interactions ISO [Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein; arsenite affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein]; Cadmium affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein]; chromium hexavalent ion affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein]; Lead affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein] CTD PMID:20655937 NCBI chr19:20,373,434...20,390,671
Ensembl chr19:20,373,428...20,390,944
JBrowse link
G App amyloid beta (A4) precursor protein multiple interactions
increases secretion
ISO Adenosine Triphosphate inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified form]; Adenosine Triphosphate inhibits the reaction [Rotenone results in decreased secretion of APP protein modified form]; Rotenone inhibits the reaction [Adenosine Triphosphate results in increased secretion of APP protein modified form]; Sodium Azide inhibits the reaction [Adenosine Triphosphate results in increased secretion of APP protein modified form] CTD PMID:22906069 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions ISO Adenosine Triphosphate promotes the reaction [RELA protein binds to ARRB2 protein]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to ARRB2 protein]]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]]; ARRB2 protein affects the reaction [Adenosine Triphosphate results in decreased activity of AGTR1A protein] CTD PMID:21464294 NCBI chr11:70,432,485...70,440,828
Ensembl chr11:70,432,635...70,440,828
JBrowse link
G Asic1 acid-sensing (proton-gated) ion channel 1 multiple interactions ISO [Acids binds to and affects the activity of ASIC1 protein] which results in increased secretion of Adenosine Triphosphate CTD PMID:19860742 NCBI chr15:99,670,197...99,701,130
Ensembl chr15:99,670,368...99,701,130
JBrowse link
G Asic2 acid-sensing (proton-gated) ion channel 2 multiple interactions ISO [Acids binds to and affects the activity of ASIC2 protein] which results in increased secretion of Adenosine Triphosphate CTD PMID:19860742 NCBI chr11:80,880,163...81,968,396
Ensembl chr11:80,880,169...81,968,457
JBrowse link
G Asic3 acid-sensing (proton-gated) ion channel 3 multiple interactions ISO [Acids binds to and affects the activity of ASIC3 protein] which results in increased secretion of Adenosine Triphosphate CTD PMID:19860742 NCBI chr 5:24,413,451...24,417,840
Ensembl chr 5:24,413,392...24,417,835
JBrowse link
G Atp7a ATPase, Cu++ transporting, alpha polypeptide multiple interactions ISO [Copper co-treated with Adenosine Triphosphate] results in increased phosphorylation of ATP7A protein CTD PMID:20964302 NCBI chr  X:106,027,224...106,128,161
Ensembl chr  X:106,027,276...106,124,926
JBrowse link
G Atp7b ATPase, Cu++ transporting, beta polypeptide multiple interactions
increases phosphorylation
ISO [Copper co-treated with Adenosine Triphosphate] results in increased phosphorylation of ATP7B protein
Adenosine Triphosphate results in increased phosphorylation of ATP7B protein
CTD PMID:19405516, PMID:20964302 NCBI chr 8:21,992,783...22,060,074
Ensembl chr 8:21,992,785...22,060,305
JBrowse link
G Atp8b1 ATPase, class I, type 8B, member 1 increases hydrolysis ISO ATP8B1 protein results in increased hydrolysis of Adenosine Triphosphate CTD PMID:11584374 NCBI chr18:64,528,979...64,661,272
Ensembl chr18:64,528,967...64,661,267
JBrowse link
G Avp arginine vasopressin multiple interactions
increases secretion
ISO Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of AVP protein]; bisindolylmaleimide I inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; Dactinomycin inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of AVP protein] CTD PMID:11102496 NCBI chr 2:130,580,620...130,582,588
Ensembl chr 2:130,580,620...130,582,554
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO [Adenosine Triphosphate binds to P2RY11 protein] which results in decreased expression of BCL2 protein CTD PMID:21503959 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcr BCR activator of RhoGEF and GTPase multiple interactions ISO [BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein; sorafenib inhibits the reaction [[BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein] CTD PMID:19366808 NCBI chr10:75,060,560...75,184,923
Ensembl chr10:75,060,592...75,184,921
JBrowse link
G Cabin1 calcineurin binding protein 1 multiple interactions ISO CABIN1 protein inhibits the reaction [Adenosine Triphosphate results in decreased expression of and results in decreased activity of AGTR1A protein] CTD PMID:21464294 NCBI chr10:75,646,110...75,764,357
Ensembl chr10:75,646,112...75,764,341
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha increases secretion
multiple interactions
ISO Adenosine Triphosphate results in increased secretion of CALCA protein
Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]]; Suramin inhibits the reaction [Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]]
CTD PMID:12044622 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Casp1 caspase 1 increases activity
multiple interactions
ISO
EXP
Adenosine Triphosphate results in increased activity of CASP1 mRNA; Adenosine Triphosphate results in increased activity of CASP1 protein
[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of CASP1 mRNA; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased secretion of and results in increased activity of CASP1 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein; fraxinellone inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein]; KN 62 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of CASP1 mRNA]; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased secretion of and results in increased activity of CASP1 protein]
[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [PML protein binds to CASP1 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein; Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP1 protein]; Arsenic Trioxide inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]
CTD PMID:18604214, PMID:19130485, PMID:21832250, PMID:23430110, PMID:24149798, PMID:25288807, PMID:25448682, PMID:26431797, PMID:26586371 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
ISO Adenosine Triphosphate results in increased expression of CASP3
Suramin inhibits the reaction [Adenosine Triphosphate results in increased expression of CASP3]
CTD PMID:19448140 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp4 caspase 4, apoptosis-related cysteine peptidase multiple interactions ISO
EXP
[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of CASP4 mRNA; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased secretion of and results in increased activity of CASP4 protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of CASP4 mRNA]; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased secretion of and results in increased activity of CASP4 protein]
Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP4 protein]
CTD PMID:24149798, PMID:25288807 NCBI chr 9:5,308,849...5,336,791
Ensembl chr 9:5,308,828...5,336,783
JBrowse link
G Cat catalase increases expression ISO Adenosine Triphosphate results in increased expression of CAT mRNA CTD PMID:22129738 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 increases secretion
multiple interactions
EXP Adenosine Triphosphate results in increased secretion of CCL3 protein
azetidine inhibits the reaction [Adenosine Triphosphate results in increased secretion of CCL3 protein]
CTD PMID:26522449 NCBI chr11:83,647,843...83,649,378
Ensembl chr11:83,647,844...83,649,355
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions ISO 3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [Adenosine Triphosphate promotes the reaction [CFTR protein results in increased export of Chlorides]]; [Phosphatidylinositol 4,5-Diphosphate co-treated with Adenosine Triphosphate] results in increased activity of CFTR protein; Adenosine Triphosphate affects the reaction [Curcumin results in increased activity of CFTR protein mutant form]; Adenosine Triphosphate binds to and results in increased activity of CFTR protein; Adenosine Triphosphate promotes the reaction [CFTR protein results in increased export of Chlorides] CTD PMID:14710196, PMID:15623556, PMID:17178710, PMID:20675434 NCBI chr 6:18,170,687...18,322,770
Ensembl chr 6:18,170,687...18,322,768
JBrowse link
G Chordc1 cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 multiple interactions ISO
EXP
Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to PPP5C protein]; Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to SUGT1 protein]
Adenosine Triphosphate binds to and affects the folding of CHORDC1 protein; Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to CHORDC1 protein]; Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to HSP90AA1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to CHORDC1 protein]
CTD PMID:23184943 NCBI chr 9:18,292,267...18,314,000
Ensembl chr 9:18,292,125...18,317,442
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate CTD PMID:14975680 NCBI chr16:18,406,882...18,426,716
Ensembl chr16:18,406,886...18,426,852
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions ISO [Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate; Carnitine promotes the reaction [[Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate] CTD PMID:21816645 NCBI chr 4:107,903,982...107,923,589
Ensembl chr 4:107,903,981...107,923,610
JBrowse link
G Crkl v-crk avian sarcoma virus CT10 oncogene homolog-like multiple interactions ISO [ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein; [BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein; sorafenib inhibits the reaction [[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein]; sorafenib inhibits the reaction [[BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein] CTD PMID:19366808 NCBI chr16:17,451,985...17,487,440
Ensembl chr16:17,451,987...17,487,434
JBrowse link
G Csnk2a1 casein kinase 2, alpha 1 polypeptide multiple interactions
affects binding
ISO 5-(3-chlorophenylamino)benzo(c)(2,6)naphthyridine-8-carboxylic acid inhibits the reaction [Adenosine Triphosphate binds to [CSNK2A1 protein binds to CSNK2A1 protein binds to CSNK2B protein binds to CSNK2B protein]] CTD PMID:21174434 NCBI chr 2:152,226,535...152,281,856
Ensembl chr 2:152,226,839...152,281,852
JBrowse link
G Csnk2b casein kinase 2, beta polypeptide multiple interactions
affects binding
ISO 5-(3-chlorophenylamino)benzo(c)(2,6)naphthyridine-8-carboxylic acid inhibits the reaction [Adenosine Triphosphate binds to [CSNK2A1 protein binds to CSNK2A1 protein binds to CSNK2B protein binds to CSNK2B protein]] CTD PMID:21174434 NCBI chr17:35,116,195...35,122,053
Ensembl chr17:35,116,196...35,122,053
JBrowse link
G Cstb cystatin B multiple interactions EXP Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP1 protein]; Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP4 protein] CTD PMID:25288807 NCBI chr10:78,425,670...78,427,622
Ensembl chr10:78,425,669...78,427,622
JBrowse link
G Ctsb cathepsin B increases activity
multiple interactions
EXP Adenosine Triphosphate results in increased activity of CTSB protein
azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of CTSB protein]
CTD PMID:26522449 NCBI chr14:63,122,462...63,145,923
Ensembl chr14:63,122,462...63,145,923
JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 increases secretion
multiple interactions
EXP Adenosine Triphosphate results in increased secretion of CXCL2 protein
azetidine inhibits the reaction [Adenosine Triphosphate results in increased secretion of CXCL2 protein]
CTD PMID:26522449 NCBI chr 5:90,903,899...90,905,938
Ensembl chr 5:90,903,871...90,905,938
JBrowse link
G Dmd dystrophin, muscular dystrophy increases secretion
multiple interactions
EXP DMD gene mutant form results in increased secretion of Adenosine Triphosphate
Nifedipine inhibits the reaction [DMD gene mutant form results in increased secretion of Adenosine Triphosphate]
CTD PMID:24349043 NCBI chr  X:82,814,664...85,205,050
Ensembl chr  X:82,948,870...85,206,141
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation
ISO sodium arsenite promotes the reaction [Adenosine Triphosphate results in increased phosphorylation of EGFR protein] CTD PMID:26104857 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO Iodoacetates inhibits the reaction [Adenosine Triphosphate results in increased expression of EGR1 mRNA]; Potassium Cyanide inhibits the reaction [Adenosine Triphosphate results in increased expression of EGR1 mRNA]; Sodium Azide inhibits the reaction [Adenosine Triphosphate results in increased expression of EGR1 mRNA] CTD PMID:10723097 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 multiple interactions ISO Adenosine Triphosphate promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein] CTD PMID:26072274 NCBI chr15:54,838,901...54,952,789
Ensembl chr15:54,838,901...54,952,892
JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 decreases activity ISO Adenosine Triphosphate results in decreased activity of ENPP7 protein CTD PMID:12885774 NCBI chr11:118,988,181...118,993,221
Ensembl chr11:118,988,188...118,993,221
JBrowse link
G Ercc6 excision repair cross-complementing rodent repair deficiency, complementation group 6 decreases abundance
multiple interactions
EXP ERCC6 gene mutant form results in decreased abundance of Adenosine Triphosphate
nicotinamide-beta-riboside inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Adenosine Triphosphate]
CTD PMID:25440059 NCBI chr14:32,513,291...32,580,990
Ensembl chr14:32,513,521...32,580,990
JBrowse link
G F2 coagulation factor II multiple interactions
increases transport
increases abundance
increases secretion
ISO
EXP
calmidazolium affects the reaction [F2 protein results in increased secretion of Adenosine Triphosphate]; Fendiline affects the reaction [F2 protein results in increased secretion of Adenosine Triphosphate]; Quercetin inhibits the reaction [F2 protein results in increased abundance of Adenosine Triphosphate]; resveratrol inhibits the reaction [F2 protein results in increased abundance of Adenosine Triphosphate]
STXBP2 protein affects the reaction [F2 protein results in increased transport of Adenosine Triphosphate]
CTD PMID:2030746, PMID:15342215, PMID:30696774 NCBI chr 2:91,612,397...91,636,457
Ensembl chr 2:91,625,320...91,636,414
JBrowse link
G Fasn fatty acid synthase multiple interactions
decreases abundance
ISO FASN protein promotes the reaction [rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]]; Protein Kinase Inhibitors inhibits the reaction [FASN protein results in decreased abundance of Adenosine Triphosphate] CTD PMID:26670611 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression
multiple interactions
ISO
EXP
Adenosine Triphosphate results in increased expression of FOS mRNA
ALPL gene mutant form promotes the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]
[Phenylephrine co-treated with Adenosine Triphosphate] results in increased expression of FOS mRNA; Glucose affects the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]; Iodoacetates inhibits the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]; Potassium Cyanide inhibits the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]; Sodium Azide inhibits the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]
CTD PMID:10723097, PMID:19463813, PMID:27466191 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Fscn1 fascin actin-bundling protein 1 increases expression
multiple interactions
ISO
EXP
Adenosine Triphosphate results in increased expression of FSCN1 mRNA
Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of FSCN1 mRNA]
CTD PMID:29733962 NCBI chr 5:142,960,355...142,973,189
Ensembl chr 5:142,960,343...142,973,185
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO Adenosine Triphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog] CTD PMID:15788719 NCBI chr 6:125,161,852...125,166,467
Ensembl chr 6:125,161,715...125,166,467
JBrowse link
G Gh growth hormone multiple interactions
increases secretion
ISO NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]; oxophenylarsine inhibits the reaction [NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]]
oxophenylarsine inhibits the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]; Phosphatidylinositol 4,5-Diphosphate affects the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]
CTD PMID:12471042 NCBI chr11:106,300,261...106,303,703
Ensembl chr11:106,300,271...106,301,865
JBrowse link
G Gja1 gap junction protein, alpha 1 increases export ISO GJA1 protein mutant form results in increased export of Adenosine Triphosphate; GJA1 protein results in increased export of Adenosine Triphosphate CTD PMID:17687502 NCBI chr10:56,377,300...56,390,419
Ensembl chr10:56,377,330...56,402,513
JBrowse link
G Gm40318 predicted gene, 40318 increases expression ISO Adenosine Triphosphate results in increased expression of S100P mRNA CTD PMID:29733962 NCBI chr 5:36,762,504...36,767,419
Ensembl chr 5:36,762,617...36,766,695
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO [GSTP1 protein co-treated with Glutathione] inhibits the reaction [[Adenosine Triphosphate results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct]; [GSTP1 protein co-treated with Glutathione] inhibits the reaction [Adenosine Triphosphate results in increased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine] CTD PMID:11196146 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO Adenosine Triphosphate inhibits the reaction [protoporphyrin IX results in decreased activity of HIF1A protein] CTD PMID:23624237 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hmgb1 high mobility group box 1 affects chemical synthesis
multiple interactions
EXP HMGB1 protein affects the chemical synthesis of Adenosine Triphosphate
Adenosine Triphosphate promotes the reaction [fullerene C60 results in increased secretion of HMGB1 protein]; Adenosine Triphosphate promotes the reaction [graphene oxide results in increased secretion of HMGB1 protein]; Adenosine Triphosphate promotes the reaction [Nanotubes, Carbon results in increased secretion of HMGB1 protein]
CTD PMID:21641551, PMID:31504961 NCBI chr 5:149,046,702...149,053,057
Ensembl chr 5:149,046,702...149,184,489
JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 multiple interactions EXP Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to HSP90AA1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]; Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]] CTD PMID:23184943 NCBI chr12:110,691,036...110,696,395
Ensembl chr12:110,690,605...110,702,728
JBrowse link
G Hspa5 heat shock protein 5 multiple interactions ISO [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 mRNA; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 mRNA]; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 protein] CTD PMID:24149798 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Hspb1 heat shock protein 1 affects chemical synthesis EXP HSPB1 protein affects the chemical synthesis of Adenosine Triphosphate CTD PMID:21641551 NCBI chr 5:135,887,919...135,889,563
Ensembl chr 5:135,887,919...135,889,563
JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) multiple interactions
increases expression
ISO bisindolylmaleimide I inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]; chelerythrine inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]; Neomycin inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]; Resveratrol inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]; tricyclodecane-9-yl-xanthogenate inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein] CTD PMID:16178011 NCBI chr 1:55,077,833...55,088,243
Ensembl chr 1:55,077,835...55,088,243
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Adenosine Triphosphate inhibits the reaction [Fructose results in increased expression of ICAM1 protein] CTD PMID:18508964 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Ifng interferon gamma multiple interactions EXP Adenosine Triphosphate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone] CTD PMID:14623498 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il12b interleukin 12b multiple interactions ISO Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:17707769 NCBI chr11:44,400,063...44,414,677
Ensembl chr11:44,400,063...44,414,033
JBrowse link
G Il18 interleukin 18 multiple interactions
increases secretion
ISO
EXP
[Adenosine Triphosphate co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL18 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein; resveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA]; resveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]
Adenosine Triphosphate results in increased secretion of IL18 protein
3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL18 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA; Acetylcysteine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]; diphenyleneiodonium inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]
CTD PMID:17404311, PMID:24149798, PMID:26431797, PMID:27311643 NCBI chr 9:50,554,700...50,581,841
Ensembl chr 9:50,554,827...50,581,840
JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP (N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1A protein]; (N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1A protein; Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein] CTD PMID:26068648 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
decreases abundance
ISO
EXP
Enzyme Inhibitors inhibits the reaction [IL1B protein results in decreased abundance of Adenosine Triphosphate]; IL1B protein inhibits the reaction [Adenosine Triphosphate results in increased secretion of INS1 protein]; Quercetin inhibits the reaction [IL1B protein inhibits the reaction [Adenosine Triphosphate results in increased secretion of INS1 protein]]
Adenosine Triphosphate results in increased secretion of IL1B protein
(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; (N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL1B protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased activity of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein; Acetylcysteine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL1B protein]; Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Adenosine Triphosphate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]; Adenosine Triphosphate promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Adenosine Triphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Arsenic Trioxide inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; diphenyleneiodonium inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL1B protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]; Okadaic Acid inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; PML protein promotes the reaction [[resiquimod co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]; zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]]
[Adenosine Triphosphate co-treated with K-12 lipopolysaccharide] results in increased secretion of IL1B protein modified form; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein; [Tetradecanoylphorbol Acetate co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein; Adenosine Triphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein; Apigenin inhibits the reaction [Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein]; flavone analog inhibits the reaction [Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein]; KN 62 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein]; MitoTEMPO inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA]; Resveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone analog inhibits the reaction [Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein]
CTD PMID:10365824, PMID:14623498, PMID:17404311, PMID:18604214, PMID:19130485, PMID:22221676, PMID:23430110, PMID:24149798, PMID:24158569, PMID:24685903, PMID:26068648, PMID:26086368, PMID:26431797, PMID:26586371, PMID:26968431, PMID:27311643, PMID:29960001 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO
EXP
Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; NF157 compound inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]; sodium arsenite promotes the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]; Suramin inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]
Adenosine Triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]; coomassie Brilliant Blue inhibits the reaction [Adenosine Triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]]; resveratrol inhibits the reaction [Adenosine Triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]]; SB 203580 inhibits the reaction [Adenosine Triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]]
azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]; MRS 2211 inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]
CTD PMID:17707769, PMID:24793913, PMID:24849676, PMID:25348860, PMID:26104857, PMID:26522449 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Ins1 insulin I multiple interactions EXP Adenosine Triphosphate inhibits the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:10535451 NCBI chr19:52,264,297...52,265,015
Ensembl chr19:52,264,297...52,265,476
JBrowse link
G Ins2 insulin II multiple interactions ISO [ammonium ferrous sulfate results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate; [chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate; INS protein inhibits the reaction [Acetaminophen results in decreased abundance of Adenosine Triphosphate]; Mannose inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate]; Phloretin inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate] CTD PMID:17965850, PMID:26739624 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381
JBrowse link
G Itgb1bp2 integrin beta 1 binding protein 2 multiple interactions ISO
EXP
Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to PPP5C protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]; Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]]
Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to CHORDC1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to ITGB1BP2 protein]; Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]]
CTD PMID:23184943 NCBI chr  X:101,449,088...101,466,122
Ensembl chr  X:101,449,088...101,453,541
JBrowse link
G Jun jun proto-oncogene multiple interactions ISO [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of JUN protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of JUN protein] CTD PMID:24149798 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Adenosine Triphosphate deficiency results in decreased activity of KCNH2 protein CTD PMID:12531891 NCBI chr 5:24,319,589...24,351,684
Ensembl chr 5:24,319,589...24,351,604
JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 multiple interactions
decreases response to substance
EXP Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]]
KCNJ11 protein mutant form results in decreased susceptibility to Adenosine Triphosphate
CTD PMID:11390963, PMID:28842488 NCBI chr 7:46,097,123...46,100,952
Ensembl chr 7:46,093,953...46,100,764
JBrowse link
G Kcnj15 potassium inwardly-rectifying channel, subfamily J, member 15 increases activity ISO Adenosine Triphosphate results in increased activity of KCNJ15 protein CTD PMID:15328350 NCBI chr16:95,257,558...95,300,260
Ensembl chr16:95,257,558...95,300,260
JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 decreases response to substance
multiple interactions
ISO KCNJ8 protein mutant form results in decreased susceptibility to Adenosine Triphosphate
Adenosine Triphosphate results in decreased activity of [KCNJ8 protein binds to ABCC9 protein]
CTD PMID:28842488 NCBI chr 6:142,564,837...142,571,614
Ensembl chr 6:142,564,837...142,571,614
JBrowse link
G Khk ketohexokinase multiple interactions ISO KHK protein promotes the reaction [Fructose results in decreased abundance of Adenosine Triphosphate] CTD PMID:19158351 NCBI chr 5:30,921,436...30,931,248
Ensembl chr 5:30,921,431...30,931,248
JBrowse link
G Kif5a kinesin family member 5A multiple interactions
increases hydrolysis
ISO Adenosine Triphosphate inhibits the reaction [zinc chloride results in decreased activity of KIF5A protein]; Cadmium Chloride inhibits the reaction [KIF5A protein results in increased hydrolysis of Adenosine Triphosphate]; Egtazic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [KIF5A protein results in increased hydrolysis of Adenosine Triphosphate]] CTD PMID:24239783, PMID:28122263 NCBI chr10:127,225,695...127,266,348
Ensembl chr10:127,225,696...127,263,348
JBrowse link
G Lep leptin multiple interactions ISO [[Glucose co-treated with INS1 protein] results in increased abundance of Adenosine Triphosphate] which results in increased secretion of LEP protein; [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein CTD PMID:10780946 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877
JBrowse link
G Lipe lipase, hormone sensitive increases activity ISO Adenosine Triphosphate results in increased activity of LIPE protein CTD PMID:7155675 NCBI chr 7:25,379,527...25,398,486
Ensembl chr 7:25,379,527...25,398,710
JBrowse link
G Lpl lipoprotein lipase affects response to substance ISO LPL protein affects the susceptibility to Adenosine Triphosphate CTD PMID:11786490 NCBI chr 8:68,880,555...68,906,932
Ensembl chr 8:68,880,491...68,907,448
JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 affects binding EXP Adenosine Triphosphate binds to MAP2K1 protein CTD PMID:17693661 NCBI chr 9:64,185,769...64,253,605
Ensembl chr 9:64,185,770...64,253,631
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
increases activity
ISO
EXP
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein]; [Alcohols co-treated with Adenosine Triphosphate] results in increased activity of MAPK1 protein; Alcohols inhibits the reaction [Adenosine Triphosphate results in increased activity of MAPK1 protein]; sodium arsenite promotes the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein]
azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein]
CTD PMID:12513686, PMID:15034929, PMID:21503959, PMID:24300283, PMID:26104857, PMID:26522449, PMID:30502331 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
increases activity
ISO
EXP
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein]; [Alcohols co-treated with Adenosine Triphosphate] results in increased activity of MAPK3 protein; Alcohols inhibits the reaction [Adenosine Triphosphate results in increased activity of MAPK3 protein]; sodium arsenite promotes the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein]
azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein]
CTD PMID:12513686, PMID:15034929, PMID:21503959, PMID:24300283, PMID:26104857, PMID:26522449, PMID:30502331 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO [annonacin results in decreased abundance of Adenosine Triphosphate] which affects the localization of MAPT protein CTD PMID:17634376 NCBI chr11:104,229,409...104,332,090
Ensembl chr11:104,231,390...104,332,090
JBrowse link
G Metrnl meteorin, glial cell differentiation regulator-like multiple interactions EXP METRNL protein inhibits the reaction [Dietary Fats results in decreased abundance of Adenosine Triphosphate] CTD PMID:30213948 NCBI chr11:121,702,427...121,717,389
Ensembl chr11:121,701,544...121,716,306
JBrowse link
G Mfn2 mitofusin 2 decreases response to substance
multiple interactions
increases chemical synthesis
EXP
ISO
MFN2 results in decreased susceptibility to Adenosine Triphosphate deficiency
MFN2 protein inhibits the reaction [TNF protein results in decreased chemical synthesis of Adenosine Triphosphate]
MFN2 protein results in increased chemical synthesis of Adenosine Triphosphate
MFN2 protein inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased chemical synthesis of Adenosine Triphosphate]
CTD PMID:22292091, PMID:24898700, PMID:25416777 NCBI chr 4:147,873,586...147,904,909
Ensembl chr 4:147,873,599...147,904,704
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases activity
increases secretion
ISO
EXP
1,10-phenanthroline inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]; SB 3CT compound inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]; wortmannin inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]
azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of MMP9 protein]
Adenosine Triphosphate results in increased secretion of MMP9 protein
CTD PMID:20195827, PMID:26522449 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G mt-Atp6 ATP synthase 6, mitochondrial affects abundance ISO ATP6 protein affects the abundance of Adenosine Triphosphate CTD PMID:18273840 NCBI chr MT:7,927...8,607
Ensembl chr MT:7,927...8,607
JBrowse link
G mt-Co3 cytochrome c oxidase III, mitochondrial increases abundance ISO COX3 protein results in increased abundance of Adenosine Triphosphate CTD PMID:17428446 NCBI chr MT:8,607...9,390
Ensembl chr MT:8,607...9,390
JBrowse link
G Mvd mevalonate (diphospho) decarboxylase increases hydrolysis ISO MVD protein results in increased hydrolysis of Adenosine Triphosphate CTD PMID:9392419 NCBI chr 8:122,433,596...122,443,422
Ensembl chr 8:122,433,601...122,443,422
JBrowse link
G Mvk mevalonate kinase multiple interactions
increases hydrolysis
ISO 3,3-dimethylallyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; dolichol monophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; Farnesol inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; farnesyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; geranyl diphosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; geranylgeranyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; isopentenyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate] CTD PMID:9392419 NCBI chr 5:114,444,264...114,460,591
Ensembl chr 5:114,444,269...114,460,591
JBrowse link
G Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta increases abundance ISO MYH7 gene mutant form results in increased abundance of Adenosine Triphosphate CTD PMID:29741611 NCBI chr14:54,970,684...54,994,626
Ensembl chr14:54,970,684...54,994,626
JBrowse link
G Nadsyn1 NAD synthetase 1 multiple interactions ISO [Ammonium Chloride co-treated with nicotinic acid adenine dinucleotide co-treated with Adenosine Triphosphate] results in increased activity of NADSYN1 protein; [NADSYN1 protein co-treated with Ammonium Chloride co-treated with nicotinic acid adenine dinucleotide co-treated with Adenosine Triphosphate] results in increased chemical synthesis of NAD CTD PMID:12547821 NCBI chr 7:143,795,589...143,822,862
Ensembl chr 7:143,795,584...143,822,849
JBrowse link
G Ncs1 neuronal calcium sensor 1 multiple interactions
increases response to substance
ISO NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]; oxophenylarsine inhibits the reaction [NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]]
NCS1 protein results in increased susceptibility to Adenosine Triphosphate
CTD PMID:12471042 NCBI chr 2:31,245,708...31,295,989
Ensembl chr 2:31,245,823...31,295,989
JBrowse link
G Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 affects localization
multiple interactions
ISO
EXP
Adenosine Triphosphate affects the localization of NFATC1 protein
azetidine analog inhibits the reaction [Adenosine Triphosphate affects the localization of NFATC1 protein]
CTD PMID:21464294, PMID:26522449 NCBI chr18:80,606,205...80,713,071
Ensembl chr18:80,606,205...80,713,071
JBrowse link
G Nfatc3 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 affects localization ISO Adenosine Triphosphate affects the localization of NFATC3 protein CTD PMID:21464294 NCBI chr 8:106,058,818...106,130,537
Ensembl chr 8:106,058,840...106,130,537
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]]
[Adenosine Triphosphate co-treated with Lipopolysaccharides] affects the localization of NFKBIA protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] affects the localization of NFKBIA protein]
CTD PMID:21464294, PMID:24149798 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Ngf nerve growth factor multiple interactions ISO [NGF protein co-treated with Adenosine Triphosphate] results in increased uptake of Calcium CTD PMID:1374475 NCBI chr 3:102,469,919...102,521,013
Ensembl chr 3:102,469,919...102,521,013
JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A multiple interactions ISO [Lipopolysaccharides co-treated with Adenosine Triphosphate co-treated with resveratrol] results in increased expression of NLRP1 mRNA CTD PMID:24149798 NCBI chr11:71,091,197...71,144,969
Ensembl chr11:71,092,236...71,144,704
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO
EXP
[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased activity of NLRP3 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate co-treated with resveratrol] results in increased expression of NLRP3 mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein; KN 62 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]
[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PML protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]]
CTD PMID:18604214, PMID:23430110, PMID:24149798, PMID:26086368, PMID:26586371 NCBI chr11:59,541,569...59,566,955
Ensembl chr11:59,541,568...59,566,956
JBrowse link
G Nolc1 nucleolar and coiled-body phosphoprotein 1 multiple interactions ISO Adenosine Triphosphate affects the reaction [Doxorubicin binds to NOLC1 protein] CTD PMID:17129415 NCBI chr19:46,075,847...46,085,543
Ensembl chr19:46,075,863...46,085,530
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
increases expression
ISO
EXP
NOS2 protein affects the reaction [Adenosine Triphosphate results in increased metabolism of RELA protein]
azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of NOS2 protein]
[Adenosine Triphosphate results in increased expression of NOS2 protein] promotes the reaction [NOS2 protein binds to RELA protein]; Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]]; Cyclosporine inhibits the reaction [[Adenosine Triphosphate results in increased expression of NOS2 protein] promotes the reaction [NOS2 protein binds to RELA protein]]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Adenosine Triphosphate results in increased expression of NOS2 protein]; NOS2 protein affects the reaction [Adenosine Triphosphate results in increased abundance of Nitric Oxide]
CTD PMID:21464294, PMID:26522449 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions ISO Adenosine Triphosphate affects the reaction [Alcohols affects the phosphorylation of NOS3 protein]; Adenosine Triphosphate inhibits the reaction [Alcohols results in decreased expression of NOS3 protein] CTD PMID:24300283 NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474
JBrowse link
G Npy neuropeptide Y affects response to substance ISO NPY protein affects the susceptibility to Adenosine Triphosphate CTD PMID:15003356 NCBI chr 6:49,822,710...49,829,507
Ensembl chr 6:49,822,710...49,829,507
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO Adenosine Triphosphate results in increased expression of NR4A1 mRNA CTD PMID:10723097 NCBI chr15:101,253,902...101,274,795
Ensembl chr15:101,254,269...101,274,795
JBrowse link
G Oas1g 2'-5' oligoadenylate synthetase 1G multiple interactions ISO [OAS1 protein results in increased metabolism of Adenosine Triphosphate] which results in increased chemical synthesis of 2',5'-oligoadenylate CTD PMID:15732009 NCBI chr 5:120,876,142...120,887,613
Ensembl chr 5:120,876,142...120,887,613
JBrowse link
G Oxt oxytocin multiple interactions
increases secretion
ISO Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of OXT protein] CTD PMID:11102496 NCBI chr 2:130,574,519...130,577,054
Ensembl chr 2:130,576,173...130,577,054
JBrowse link
G P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1 multiple interactions ISO geldanamycin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1]; herbimycin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1]; monorden promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1] CTD PMID:11930156 NCBI chr11:72,999,056...73,015,200
Ensembl chr11:72,999,103...73,015,200
JBrowse link
G P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 multiple interactions
increases activity
affects response to substance
ISO
EXP
1-amino-4-(3-(4,6-dichloro(1,3,5)triazine-2-ylamino)phenylamino)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; Acetylcysteine inhibits the reaction [Rotenone promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; Cadmium Chloride affects the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; cobaltous chloride affects the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Copper promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; cupric chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Mercuric Chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Mercury promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; methyl methanethiosulfonate inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; methyl methanethiosulfonate inhibits the reaction [Mercury promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; myxothiazol promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; nickel chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; palladium chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Rotenone promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; zinc chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Zinc promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]
P2RX2 protein affects the susceptibility to Adenosine Triphosphate
CTD PMID:15081800, PMID:16190872, PMID:19793987, PMID:21207957 NCBI chr 5:110,339,812...110,343,320
Ensembl chr 5:110,339,812...110,343,212
JBrowse link
G P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 multiple interactions
affects activity
ISO Eugenol inhibits the reaction [P2RX3 protein affects the activity of Adenosine Triphosphate] CTD PMID:19967073 NCBI chr 2:84,996,549...85,037,108
Ensembl chr 2:84,998,583...85,037,462
JBrowse link
G P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 multiple interactions
increases activity
ISO
EXP
[Cadmium co-treated with Zinc] promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; [Mercury co-treated with Copper] inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Cadmium promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Cobalt promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Copper inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Copper inhibits the reaction [Zinc promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]]; Mercury inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Zinc promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]
5-(3-bromophenyl)-1,3-dihydro-2H-benzofuro(3,2-e)-1,4-diazepin-2-one inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; [ginsenoside M1 co-treated with Adenosine Triphosphate] results in increased activity of P2RX4 protein; [Resveratrol co-treated with Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX4 mRNA; [Resveratrol co-treated with Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX4 protein; ginsenoside M1 promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; ginsenoside Rb1 promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; ginsenoside Rd promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Ivermectin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]
CTD PMID:10737610, PMID:15629187, PMID:19793987, PMID:21638035, PMID:24149798, PMID:30545933 NCBI chr 5:122,707,518...122,729,739
Ensembl chr 5:122,707,544...122,729,738
JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 multiple interactions
increases expression
decreases response to substance
increases response to substance
increases activity
ISO
EXP
[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 mRNA; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 protein; AZ10606120 inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]; P2RX7 protein affects the reaction [Adenosine Triphosphate results in increased secretion of SELL protein]; P2RX7 protein affects the reaction [Adenosine Triphosphate results in increased transport of Barium]; Resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 mRNA]; Resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 protein]
Adenosine Triphosphate results in increased expression of P2RX7 protein
P2RX7 gene mutant form results in decreased susceptibility to Adenosine Triphosphate
P2RX7 protein results in increased susceptibility to Adenosine Triphosphate
3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]; azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of P2RX7 protein]; coomassie Brilliant Blue inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]
CTD PMID:11003599, PMID:17728465, PMID:19023039, PMID:21638035, PMID:23565201, PMID:24101734, PMID:24149798, PMID:26522449, PMID:27466191, PMID:30545933, PMID:31504961 NCBI chr 5:122,643,927...122,692,336
Ensembl chr 5:122,643,911...122,691,432
JBrowse link
G P2ry1 purinergic receptor P2Y, G-protein coupled 1 multiple interactions
affects activity
ISO
EXP
[Adenosine Triphosphate binds to and results in increased activity of P2RY1 protein] which results in increased abundance of Calcium; Adenosine Triphosphate binds to and results in increased activity of P2RY1 protein; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [P2RY1 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]]; P2RY1 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]; Trichloroethylene inhibits the reaction [[Adenosine Triphosphate binds to and results in increased activity of P2RY1 protein] which results in increased abundance of Calcium]
[N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate binds to and results in decreased activity of P2RY1 protein] inhibits the reaction [Adenosine Triphosphate results in increased uptake of Calcium]
Adenosine Triphosphate affects the activity of P2RY1 protein
CTD PMID:12694404, PMID:15243297, PMID:16973929, PMID:22129738 NCBI chr 3:61,002,785...61,008,982
Ensembl chr 3:61,002,795...61,008,982
JBrowse link
G P2ry13 purinergic receptor P2Y, G-protein coupled 13 multiple interactions ISO MRS 2211 inhibits the reaction [P2RY13 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]]; P2RY13 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide] CTD PMID:22129738 NCBI chr 3:59,207,892...59,210,882
Ensembl chr 3:59,207,892...59,210,882
JBrowse link
G P2ry2 purinergic receptor P2Y, G-protein coupled 2 multiple interactions
affects activity
increases activity
ISO
EXP
[Adenosine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Calcium
[Adenosine Triphosphate results in increased activity of P2RY2 protein] which results in increased uptake of Calcium
Adenosine Triphosphate affects the activity of P2RY2 protein
CTD PMID:11527950, PMID:15243297, PMID:17003265 NCBI chr 7:100,996,568...101,012,053
Ensembl chr 7:100,996,568...101,012,866
JBrowse link
G P2ry4 pyrimidinergic receptor P2Y, G-protein coupled, 4 multiple interactions ISO [Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium; Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein; Trichloroethylene inhibits the reaction [[Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium] CTD PMID:12694404 NCBI chr  X:100,588,358...100,594,927
Ensembl chr  X:100,590,154...100,594,869
JBrowse link
G P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 multiple interactions ISO N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea inhibits the reaction [P2RY6 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]]; P2RY6 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide] CTD PMID:22129738 NCBI chr 7:100,937,630...100,975,498
Ensembl chr 7:100,937,630...100,974,649
JBrowse link
G Panx1 pannexin 1 decreases activity
multiple interactions
increases export
ISO
EXP
Adenosine Triphosphate results in decreased activity of PANX1 protein
Carbenoxolone inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate]; Probenecid inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate]
CTD PMID:19023039, PMID:19213873 NCBI chr 9:15,005,785...15,045,478
Ensembl chr 9:15,002,128...15,045,478
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases expression
ISO
EXP
PARP1 mutant form inhibits the reaction [Cadmium results in decreased abundance of Adenosine Triphosphate]
PARP1 protein affects the reaction [pyrithione zinc results in decreased abundance of Adenosine Triphosphate]; PARP1 protein affects the reaction [Zinc results in decreased abundance of Adenosine Triphosphate]
Adenosine Triphosphate results in increased expression of PARP1 protein
CTD PMID:17728843, PMID:19809895, PMID:21767558, PMID:22253048 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 multiple interactions
affects response to substance
EXP [PDK1 protein affects the susceptibility to Adenosine Triphosphate] which affects the abundance of Calcium; Adenosine Triphosphate promotes the reaction [PDK1 protein affects the abundance of Calcium]; tubacin affects the reaction [[PDK1 protein affects the susceptibility to Adenosine Triphosphate] which affects the abundance of Calcium] CTD PMID:28887310 NCBI chr 2:71,873,215...71,903,858
Ensembl chr 2:71,873,224...71,903,858
JBrowse link
G Pfkm phosphofructokinase, muscle multiple interactions ISO Adenosine Triphosphate promotes the reaction [resveratrol results in decreased activity of PFKM protein] CTD PMID:23454376 NCBI chr15:98,092,589...98,132,447
Ensembl chr15:98,092,589...98,132,451
JBrowse link
G Pgp phosphoglycolate phosphatase decreases phosphorylation EXP PGP protein results in decreased phosphorylation of Adenosine Triphosphate CTD PMID:24338473 NCBI chr17:24,470,426...24,473,110
Ensembl chr17:24,470,392...24,473,110
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha multiple interactions
affects binding
ISO 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine inhibits the reaction [Adenosine Triphosphate binds to PIK3CA protein]; Adenosine Triphosphate inhibits the reaction [resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]] CTD PMID:17550345, PMID:18754654 NCBI chr 3:32,397,065...32,466,112
Ensembl chr 3:32,397,671...32,468,486
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO Adenosine Triphosphate inhibits the reaction [resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]] CTD PMID:17550345 NCBI chr13:101,680,761...101,768,217
Ensembl chr13:101,680,563...101,768,217
JBrowse link
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) increases activity EXP Adenosine Triphosphate results in increased activity of PLA2G4A protein CTD PMID:10535451 NCBI chr 1:149,829,618...149,961,290
Ensembl chr 1:149,829,618...149,961,290
JBrowse link
G Plau plasminogen activator, urokinase increases secretion EXP Adenosine Triphosphate results in increased secretion of PLAU protein CTD PMID:20177776 NCBI chr14:20,836,662...20,843,388
Ensembl chr14:20,836,660...20,843,385
JBrowse link
G Plpp3 phospholipid phosphatase 3 decreases chemical synthesis EXP PLPP3 gene mutant form results in decreased chemical synthesis of Adenosine Triphosphate CTD PMID:28982073 NCBI chr 4:105,157,347...105,232,767
Ensembl chr 4:105,157,347...105,232,764
JBrowse link
G Pml promyelocytic leukemia multiple interactions EXP [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PML protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [PML protein binds to CASP1 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of PML protein; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased abundance of Reactive Oxygen Species]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; PML protein promotes the reaction [[resiquimod co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein] CTD PMID:23430110 NCBI chr 9:58,217,179...58,249,796
Ensembl chr 9:58,218,076...58,249,786
JBrowse link
G Pmvk phosphomevalonate kinase increases hydrolysis ISO PMVK protein results in increased hydrolysis of Adenosine Triphosphate CTD PMID:9392419 NCBI chr 3:89,454,541...89,469,014
Ensembl chr 3:89,454,541...89,469,013
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [Fenofibrate results in increased activity of PPARA protein] which results in decreased abundance of Adenosine Triphosphate CTD PMID:19593819 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
decreases abundance
ISO FASN protein promotes the reaction [rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]]; rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]; UCP1 protein promotes the reaction [PPARG protein mutant form results in decreased abundance of Adenosine Triphosphate]; UCP1 protein promotes the reaction [rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]]
PPARG protein mutant form results in decreased abundance of Adenosine Triphosphate; PPARG protein results in decreased abundance of Adenosine Triphosphate
CTD PMID:26670611 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit multiple interactions ISO Adenosine Triphosphate binds to and affects the folding of PPP5C protein; Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to PPP5C protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to PPP5C protein] CTD PMID:23184943 NCBI chr 7:17,004,640...17,027,914
Ensembl chr 7:17,004,640...17,027,924
JBrowse link
G Prdx2 peroxiredoxin 2 increases expression ISO Adenosine Triphosphate results in increased expression of PRDX2 protein modified form CTD PMID:16178011 NCBI chr 8:84,969,622...84,974,811
Ensembl chr 8:84,969,587...84,974,834
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO [[Adenosine Triphosphate co-treated with PRKCA protein] results in increased phosphorylation of RALBP1 protein] which results in increased transport of Doxorubicin CTD PMID:16087181 NCBI chr11:107,933,387...108,343,888
Ensembl chr11:107,933,387...108,343,928
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of PTGS2 protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of PTGS2 protein] CTD PMID:24149798 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO
EXP
[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in decreased expression of PYCARD mRNA; resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in decreased expression of PYCARD mRNA]
[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]]; PYCARD gene mutant form inhibits the reaction [Adenosine Triphosphate results in increased abundance of G(M3) Ganglioside]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]
CTD PMID:18604214, PMID:23430110, PMID:24149798, PMID:24475307 NCBI chr 7:127,991,373...127,993,867
Ensembl chr 7:127,989,708...127,993,867
JBrowse link
G Ralbp1 ralA binding protein 1 multiple interactions ISO [[Adenosine Triphosphate co-treated with PRKCA protein] results in increased phosphorylation of RALBP1 protein] which results in increased transport of Doxorubicin; Adenosine Triphosphate promotes the reaction [RALBP1 protein affects the transport of Leukotriene C4] CTD PMID:15386349, PMID:16087181 NCBI chr17:65,848,415...65,885,755
Ensembl chr17:65,848,418...65,885,798
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO [Adenosine Triphosphate results in increased expression of NOS2 protein] promotes the reaction [NOS2 protein binds to RELA protein]; Adenosine Triphosphate promotes the reaction [RELA protein binds to ARRB2 protein]; Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]; Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to ARRB2 protein]]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]]; Cyclosporine inhibits the reaction [[Adenosine Triphosphate results in increased expression of NOS2 protein] promotes the reaction [NOS2 protein binds to RELA protein]]
[Adenosine Triphosphate co-treated with Lipopolysaccharides] affects the localization of RELA protein; NOS2 protein affects the reaction [Adenosine Triphosphate results in increased metabolism of RELA protein]; resveratrol promotes the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] affects the localization of RELA protein]; S-Nitrosoglutathione promotes the reaction [Adenosine Triphosphate results in increased metabolism of RELA protein]
CTD PMID:21464294, PMID:24149798 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rhof ras homolog family member F (in filopodia) increases expression
multiple interactions
ISO
EXP
Adenosine Triphosphate results in increased expression of RHOF mRNA
Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of RHOF mRNA]
CTD PMID:29733962 NCBI chr 5:123,118,180...123,141,808
Ensembl chr 5:123,103,044...123,132,692
JBrowse link
G S100a10 S100 calcium binding protein A10 (calpactin) increases expression ISO Adenosine Triphosphate results in increased expression of S100A10 mRNA CTD PMID:29733962 NCBI chr 3:93,555,117...93,564,645
Ensembl chr 3:93,555,080...93,564,643
JBrowse link
G S100a11 S100 calcium binding protein A11 increases expression ISO Adenosine Triphosphate results in increased expression of S100A11 mRNA CTD PMID:29733962 NCBI chr 3:93,520,496...93,526,288
Ensembl chr 3:93,520,488...93,526,287
JBrowse link
G S100a4 S100 calcium binding protein A4 multiple interactions
increases expression
EXP
ISO
Adenosine Triphosphate results in increased expression of and results in increased secretion of S100A4 protein; Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of S100A4 protein]
Adenosine Triphosphate results in increased expression of S100A4 mRNA
CTD PMID:29733962 NCBI chr 3:90,603,770...90,606,045
Ensembl chr 3:90,603,771...90,606,045
JBrowse link
G S100a6 S100 calcium binding protein A6 (calcyclin) increases expression ISO Adenosine Triphosphate results in increased expression of S100A6 mRNA CTD PMID:29733962 NCBI chr 3:90,612,894...90,614,414
Ensembl chr 3:90,612,882...90,624,181
JBrowse link
G Sell selectin, lymphocyte multiple interactions ISO P2RX7 protein affects the reaction [Adenosine Triphosphate results in increased secretion of SELL protein] CTD PMID:11003599 NCBI chr 1:164,061,987...164,082,930
Ensembl chr 1:164,061,982...164,084,181
JBrowse link
G Sftpa1 surfactant associated protein A1 multiple interactions ISO [SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]; Ozone inhibits the reaction [[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]; Ozone inhibits the reaction [SFTPA1 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]] CTD PMID:15065867 NCBI chr14:41,131,788...41,136,373
Ensembl chr14:41,131,782...41,136,452
JBrowse link
G Sftpb surfactant associated protein B increases secretion
multiple interactions
EXP
ISO
Adenosine Triphosphate results in increased secretion of SFTPB protein
Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPB protein]
CTD PMID:11704537, PMID:14565945 NCBI chr 6:72,304,610...72,314,373
Ensembl chr 6:72,304,610...72,314,371
JBrowse link
G Sftpc surfactant associated protein C increases secretion
multiple interactions
ISO
EXP
Adenosine Triphosphate results in increased secretion of SFTPC protein
Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPC protein]
CTD PMID:11704537, PMID:14565945 NCBI chr14:70,520,941...70,524,081
Ensembl chr14:70,520,949...70,524,081
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO [SIRT1 protein results in decreased expression of UCP2 mRNA] promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate]; SIRT1 protein promotes the reaction [[Glucose results in increased abundance of Adenosine Triphosphate] which results in increased expression of INS1 protein]; SIRT1 protein promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate] CTD PMID:16366736 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704
JBrowse link
G Sirt3 sirtuin 3 multiple interactions EXP SIRT3 protein inhibits the reaction [Metformin results in decreased abundance of Adenosine Triphosphate] CTD PMID:23166782 NCBI chr 7:140,863,663...140,882,309
Ensembl chr 7:140,863,666...140,882,309
JBrowse link
G Slc25a14 solute carrier family 25 (mitochondrial carrier, brain), member 14 decreases chemical synthesis ISO SLC25A14 protein results in decreased chemical synthesis of Adenosine Triphosphate CTD PMID:20600837 NCBI chr  X:48,623,418...48,662,298
Ensembl chr  X:48,623,413...48,662,294
JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 decreases stability ISO Adenosine Triphosphate results in decreased stability of SLC2A1 protein CTD PMID:11420438 NCBI chr 4:119,108,745...119,137,330
Ensembl chr 4:119,108,711...119,137,983
JBrowse link
G Slc46a1 solute carrier family 46, member 1 multiple interactions ISO [SLC46A1 protein results in increased susceptibility to N-((5-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)propyl)thiophen-2-yl)carbonyl)glutamic acid] which results in decreased chemical synthesis of Adenosine Triphosphate CTD PMID:21879757 NCBI chr11:78,465,701...78,471,945
Ensembl chr11:78,465,697...78,472,059
JBrowse link
G Slc5a5 solute carrier family 5 (sodium iodide symporter), member 5 multiple interactions ISO Adenosine Triphosphate inhibits the reaction [TSHB protein results in increased expression of SLC5A5 protein] CTD PMID:16439463 NCBI chr 8:70,882,885...70,892,785
Ensembl chr 8:70,882,889...70,892,757
JBrowse link
G Snca synuclein, alpha multiple interactions
decreases abundance
ISO GW8510 inhibits the reaction [SNCA protein results in decreased abundance of Adenosine Triphosphate]; SB 216763 inhibits the reaction [SNCA protein results in decreased abundance of Adenosine Triphosphate] CTD PMID:24989254 NCBI chr 6:60,731,573...60,829,855
Ensembl chr 6:60,731,575...60,829,855
JBrowse link
G Sod1 superoxide dismutase 1, soluble increases expression ISO Adenosine Triphosphate results in increased expression of SOD1 protein CTD PMID:16178011, PMID:22129738 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial affects chemical synthesis
decreases abundance
multiple interactions
EXP SOD2 protein affects the chemical synthesis of Adenosine Triphosphate
SOD2 gene mutant form results in decreased abundance of Adenosine Triphosphate
MK-886 promotes the reaction [SOD2 gene mutant form results in decreased abundance of Adenosine Triphosphate]
CTD PMID:20638473, PMID:25362851 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Stxbp2 syntaxin binding protein 2 multiple interactions EXP STXBP2 protein affects the reaction [F2 protein results in increased transport of Adenosine Triphosphate] CTD PMID:30696774 NCBI chr 8:3,630,960...3,643,998
Ensembl chr 8:3,630,955...3,643,644
JBrowse link
G Sugt1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) multiple interactions ISO Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to SUGT1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]; Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]] CTD PMID:23184943 NCBI chr14:79,587,660...79,630,797
Ensembl chr14:79,587,691...79,635,196
JBrowse link
G Syn2 synapsin II multiple interactions EXP SYN2 mutant form inhibits the reaction [Adenosine Triphosphate results in increased abundance of Calcium] CTD PMID:18701217 NCBI chr 6:115,134,902...115,282,626
Ensembl chr 6:115,134,902...115,282,006
JBrowse link
G Tac1 tachykinin 1 increases secretion
multiple interactions
ISO Adenosine Triphosphate results in increased secretion of TAC1 protein
Iloprost promotes the reaction [Adenosine Triphosphate results in increased secretion of TAC1 protein]
CTD PMID:16039053 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834
JBrowse link
G Taldo1 transaldolase 1 increases abundance EXP TALDO1 gene mutant form results in increased abundance of Adenosine Triphosphate CTD PMID:19436114 NCBI chr 7:141,392,160...141,402,976
Ensembl chr 7:141,392,199...141,402,968
JBrowse link
G Tas2r115 taste receptor, type 2, member 115 increases activity EXP Adenosine Triphosphate results in increased activity of TAS2R115 protein CTD PMID:29347925 NCBI chr 6:132,737,054...132,737,986
Ensembl chr 6:132,737,003...132,738,035
JBrowse link
G Tas2r131 taste receptor, type 2, member 131 increases activity EXP Adenosine Triphosphate results in increased activity of TAS2R131 protein CTD PMID:29347925 NCBI chr 6:132,956,912...132,957,844
Ensembl chr 6:132,956,884...132,957,919
JBrowse link
G Tas2r143 taste receptor, type 2, member 143 increases activity EXP Adenosine Triphosphate results in increased activity of TAS2R143 protein CTD PMID:29347925 NCBI chr 6:42,400,238...42,401,119
Ensembl chr 6:42,400,238...42,401,119
JBrowse link
G Timm17a translocase of inner mitochondrial membrane 17a multiple interactions
decreases expression
ISO 1,10-phenanthroline inhibits the reaction [Adenosine Triphosphate results in decreased expression of TIMM17A protein] CTD PMID:24315374 NCBI chr 1:135,301,535...135,313,737
Ensembl chr 1:135,295,213...135,313,778
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 decreases secretion
multiple interactions
EXP Adenosine Triphosphate results in decreased secretion of TIMP1 protein
azetidine analog inhibits the reaction [Adenosine Triphosphate results in decreased secretion of TIMP1 protein]
CTD PMID:26522449 NCBI chr  X:20,870,166...20,874,737
Ensembl chr  X:20,870,166...20,874,735
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases chemical synthesis
EXP
ISO
[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of TNF protein; Adenosine Triphosphate deficiency inhibits the reaction [TNF protein results in increased transport of Chlorides]; Adenosine Triphosphate deficiency inhibits the reaction [TNF protein results in increased transport of Potassium]; Adenosine Triphosphate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]; azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased secretion of TNF protein]
TNF protein promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased chemical synthesis of Adenosine Triphosphate]
TNF protein results in decreased chemical synthesis of Adenosine Triphosphate
[Asbestos, Amosite co-treated with TNF protein] results in increased metabolism of Adenosine Triphosphate; Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; MFN2 protein inhibits the reaction [TNF protein results in decreased chemical synthesis of Adenosine Triphosphate]; Rosiglitazone inhibits the reaction [TNF protein results in decreased chemical synthesis of Adenosine Triphosphate]; Vitamin K 3 promotes the reaction [[Asbestos, Amosite co-treated with TNF protein] results in increased metabolism of Adenosine Triphosphate]
CTD PMID:8817062, PMID:10783394, PMID:14623498, PMID:17707769, PMID:23430110, PMID:24898700, PMID:26522449 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 increases abundance EXP TNFSF11 protein results in increased abundance of Adenosine Triphosphate CTD PMID:26287518 NCBI chr14:78,277,446...78,308,043
Ensembl chr14:78,277,445...78,308,043
JBrowse link
G Top2a topoisomerase (DNA) II alpha multiple interactions
increases hydrolysis
ISO Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]; copper-thiosemicarbazone complex analog inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]; Dithiothreitol inhibits the reaction [Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]]; Emodin inhibits the reaction [TOP2A results in increased hydrolysis of Adenosine Triphosphate]; Etoposide metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]; Thiosemicarbazones analog inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]
TOP2A protein results in increased hydrolysis of Adenosine Triphosphate; TOP2A results in increased hydrolysis of Adenosine Triphosphate
CTD PMID:20855424, PMID:26982206, PMID:27533850, PMID:29272108 NCBI chr11:98,992,947...99,024,199
Ensembl chr11:98,992,943...99,024,189
JBrowse link
G Top2b topoisomerase (DNA) II beta multiple interactions
increases hydrolysis
ISO cannabidiol hydroxyquinone inhibits the reaction [TOP2B protein results in increased hydrolysis of Adenosine Triphosphate]; Cannabidiol metabolite inhibits the reaction [TOP2B protein results in increased hydrolysis of Adenosine Triphosphate] CTD PMID:29272108 NCBI chr14:16,365,206...16,430,787
Ensembl chr14:16,365,179...16,435,462
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO TP53 protein inhibits the reaction [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] CTD PMID:21042727 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 decreases activity EXP
ISO
Adenosine Triphosphate results in decreased activity of TRPM4 protein CTD PMID:16966582, PMID:17188667 NCBI chr 7:45,303,155...45,334,071
Ensembl chr 7:45,302,632...45,333,780
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO [Capsaicin binds to and affects the activity of TRPV1 protein] which results in increased secretion of Adenosine Triphosphate CTD PMID:19860742 NCBI chr11:73,234,149...73,261,322
Ensembl chr11:73,234,292...73,261,242
JBrowse link
G Tshb thyroid stimulating hormone, beta subunit multiple interactions ISO Adenosine Triphosphate inhibits the reaction [TSHB protein results in increased expression of SLC5A5 protein] CTD PMID:16439463 NCBI chr 3:102,777,398...102,789,082
Ensembl chr 3:102,775,465...102,782,718
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Adenosine Triphosphate results in increased expression of TXN protein CTD PMID:22129738 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
G Txnip thioredoxin interacting protein increases activity ISO Adenosine Triphosphate results in increased activity of TXNIP mRNA CTD PMID:21832250 NCBI chr 3:96,557,957...96,561,857
Ensembl chr 3:96,557,957...96,561,883
JBrowse link
G Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) multiple interactions
decreases abundance
ISO
EXP
Adenosine Triphosphate inhibits the reaction [UCP1 protein results in increased transport of Protons]
UCP1 results in decreased abundance of Adenosine Triphosphate
UCP1 protein promotes the reaction [PPARG protein mutant form results in decreased abundance of Adenosine Triphosphate]; UCP1 protein promotes the reaction [rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]]
CTD PMID:12734183, PMID:26670611 NCBI chr 8:83,290,348...83,298,456
Ensembl chr 8:83,290,352...83,298,452
JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) multiple interactions ISO Adenosine Triphosphate inhibits the reaction [UCP2 protein results in increased transport of Protons]
[SIRT1 protein results in decreased expression of UCP2 mRNA] promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate]
CTD PMID:12734183, PMID:16366736 NCBI chr 7:100,493,337...100,499,629
Ensembl chr 7:100,493,337...100,502,020
JBrowse link
G Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) multiple interactions ISO Adenosine Triphosphate inhibits the reaction [UCP3 protein results in increased transport of Protons] CTD PMID:12734183 NCBI chr 7:100,472,991...100,486,432
Ensembl chr 7:100,472,990...100,486,432
JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions ISO VDAC1 mutant form inhibits the reaction [chromium hexavalent ion results in decreased abundance of Adenosine Triphosphate] CTD PMID:22858589 NCBI chr11:52,360,851...52,389,397
Ensembl chr11:52,360,860...52,389,397
JBrowse link
atropine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 multiple interactions
decreases activity
ISO Atropine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atropine results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616
JBrowse link
G Abl1 c-abl oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA CTD PMID:17390078 NCBI chr 2:31,688,244...31,807,093
Ensembl chr 2:31,688,376...31,804,227
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO
EXP
Atropine inhibits the reaction [[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine]; Atropine inhibits the reaction [Carbachol results in increased metabolism of and results in increased secretion of ACHE protein]; Atropine inhibits the reaction [Paraoxon results in increased expression of ACHE protein]
[Atropine co-treated with Obidoxime Chloride] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; [tariquidar co-treated with asoxime chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with cucurbit(7)uril] co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]
CTD PMID:2241428, PMID:10421444, PMID:17963125, PMID:20105433, PMID:21600273, PMID:21787676, PMID:22783142, PMID:23047022, PMID:24881594, PMID:26751814, PMID:31794810 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Adcy5 adenylate cyclase 5 increases response to substance EXP ADCY5 protein results in increased susceptibility to Atropine CTD PMID:12869393 NCBI chr16:35,154,494...35,305,743
Ensembl chr16:35,154,877...35,305,738
JBrowse link
G Aqp5 aquaporin 5 multiple interactions EXP Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein] CTD PMID:26208470 NCBI chr15:99,591,028...99,594,829
Ensembl chr15:99,590,782...99,594,829
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the expression of BAX mRNA] CTD PMID:21971501 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcar1 breast cancer anti-estrogen resistance 1 multiple interactions ISO Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]] CTD PMID:10537051 NCBI chr 8:111,710,474...111,743,849
Ensembl chr 8:111,710,474...111,743,809
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO [Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein
[BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX
CTD PMID:17963125, PMID:22981459 NCBI chr 3:73,635,805...73,708,436
Ensembl chr 3:73,635,808...73,708,415
JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 multiple interactions EXP BDKRB2 affects the susceptibility to [Propranolol co-treated with Atropine] CTD PMID:10614985 NCBI chr12:105,563,172...105,595,244
Ensembl chr12:105,563,226...105,595,237
JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of BMP6 mRNA] CTD PMID:18472332 NCBI chr13:38,345,716...38,500,314
Ensembl chr13:38,345,107...38,500,302
JBrowse link
G Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit multiple interactions ISO Atropine inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]] CTD PMID:12663092 NCBI chr 1:154,390,806...154,884,785
Ensembl chr 1:154,390,731...154,884,501
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha affects activity ISO Atropine affects the activity of CALCA protein CTD PMID:7906887, PMID:10075105 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Casp3 caspase 3 increases expression ISO Atropine results in increased expression of CASP3 mRNA CTD PMID:19815060 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 multiple interactions EXP [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 protein] CTD PMID:22245128 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518
JBrowse link
G Ccna1 cyclin A1 increases expression
multiple interactions
ISO Atropine results in increased expression of CCNA1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNA1 mRNA
CTD PMID:17390078 NCBI chr 3:55,045,469...55,057,634
Ensembl chr 3:55,045,469...55,055,501
JBrowse link
G Ccnd3 cyclin D3 multiple interactions ISO [Parathion co-treated with Atropine] results in increased expression of CCND3 mRNA CTD PMID:17390078 NCBI chr17:47,505,051...47,599,689
Ensembl chr17:47,505,051...47,599,691
JBrowse link
G Ccne1 cyclin E1 increases expression
multiple interactions
ISO Atropine results in increased expression of CCNE1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA
CTD PMID:17390078 NCBI chr 7:38,097,984...38,107,490
Ensembl chr 7:38,097,984...38,107,534
JBrowse link
G Ccne2 cyclin E2 multiple interactions
increases expression
ISO [Parathion co-treated with Atropine] results in increased expression of CCNE2 mRNA
Atropine results in increased expression of CCNE2 mRNA
CTD PMID:17390078 NCBI chr 4:11,190,433...11,204,779
Ensembl chr 4:11,191,351...11,204,779
JBrowse link
G Cd40 CD40 antigen multiple interactions ISO Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein] CTD PMID:16879495 NCBI chr 2:165,055,614...165,071,654
Ensembl chr 2:165,055,627...165,072,948
JBrowse link
G Cdc20 cell division cycle 20 multiple interactions
increases expression
ISO [Parathion co-treated with Atropine] results in increased expression of CDC20 mRNA
Atropine results in increased expression of CDC20 mRNA
CTD PMID:17390078 NCBI chr 4:118,432,901...118,437,343
Ensembl chr 4:118,432,901...118,437,352
JBrowse link
G Cdc6 cell division cycle 6 multiple interactions ISO [Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA CTD PMID:17390078 NCBI chr11:98,907,709...98,923,942
Ensembl chr11:98,907,801...98,923,940
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
increases expression
ISO [Parathion co-treated with Atropine] results in increased expression of CDK1 mRNA
Atropine results in increased expression of CDK1 mRNA
CTD PMID:17390078 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] CTD PMID:9311626 NCBI chr 8:93,166,072...93,197,804
Ensembl chr 8:93,166,068...93,197,838
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1, CNS multiple interactions
decreases activity
EXP
ISO
Atropine binds to and results in decreased activity of CHRM1 protein; Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
Atropine results in decreased activity of CHRM1 protein
Atropine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]
CTD PMID:16439611, PMID:18316702, PMID:31830555 NCBI chr19:8,664,005...8,683,606
Ensembl chr19:8,663,789...8,683,587
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2, cardiac multiple interactions ISO Atropine binds to and results in decreased activity of CHRM2 protein CTD PMID:15140916 NCBI chr 6:36,387,991...36,528,638
Ensembl chr 6:36,388,084...36,528,414
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3, cardiac multiple interactions
decreases activity
ISO Atropine binds to and results in decreased activity of CHRM3 protein; Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]
Atropine results in decreased activity of CHRM3 protein
CTD PMID:15140916, PMID:20708676, PMID:31830555 NCBI chr13:9,875,486...10,361,062
Ensembl chr13:9,875,486...10,360,847
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions
affects binding
ISO [WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Atropine binds to CHRM4 protein] CTD PMID:16709648 NCBI chr 2:91,922,189...91,929,835
Ensembl chr 2:91,927,249...91,928,688
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 multiple interactions ISO Atropine inhibits the reaction [Acetylcholine results in increased activity of CHRM5 protein] CTD PMID:31323226 NCBI chr 2:112,478,733...112,536,361
Ensembl chr 2:112,479,171...112,480,769
JBrowse link
G Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 multiple interactions
affects binding
ISO Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]]
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
CTD PMID:15733544, PMID:21791372 NCBI chr 2:181,022,311...181,043,579
Ensembl chr 2:181,018,380...181,043,546
JBrowse link
G Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) affects binding
multiple interactions
ISO Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:15733544, PMID:21791372 NCBI chr 3:89,753,448...89,764,632
Ensembl chr 3:89,746,195...89,764,632
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein] CTD PMID:21971501 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Crh corticotropin releasing hormone multiple interactions ISO Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]
[Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH protein
CTD PMID:12039681, PMID:12906840 NCBI chr 3:19,693,401...19,695,396
Ensembl chr 3:19,693,401...19,695,396
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein mutant form]; Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein] CTD PMID:17390078 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Cxcl3 chemokine (C-X-C motif) ligand 3 multiple interactions EXP [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 protein] CTD PMID:22245128 NCBI chr 5:90,786,101...90,788,093
Ensembl chr 5:90,786,103...90,789,600
JBrowse link
G Dvl2 dishevelled segment polarity protein 2 multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of DVL2 protein] CTD PMID:17390078 NCBI chr11:70,000,592...70,010,109
Ensembl chr11:70,000,595...70,012,301
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO EDN1 protein results in decreased activity of [Atropine co-treated with Histamine] CTD PMID:12906840 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of EGFR protein] CTD PMID:17390078 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA] CTD PMID:7968354 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Egr2 early growth response 2 multiple interactions ISO Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA] CTD PMID:7968354 NCBI chr10:67,534,469...67,542,188
Ensembl chr10:67,535,475...67,542,188
JBrowse link
G Ezr ezrin multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of EZR protein] CTD PMID:17390078 NCBI chr17:6,738,131...6,782,780
Ensembl chr17:6,738,041...6,782,784
JBrowse link
G F2 coagulation factor II multiple interactions EXP [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in decreased expression of F2 mRNA; [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased activity of F2 protein CTD PMID:30515700 NCBI chr 2:91,612,397...91,636,457
Ensembl chr 2:91,625,320...91,636,414
JBrowse link
G F2r coagulation factor II (thrombin) receptor multiple interactions EXP [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased expression of F2R protein CTD PMID:30515700 NCBI chr13:95,601,780...95,618,466
Ensembl chr13:95,601,803...95,618,487
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression
multiple interactions
ISO Atropine results in increased expression of FOS protein
Atropine inhibits the reaction [Paraoxon results in increased expression of FOS mRNA]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased expression of FOS protein]; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]
CTD PMID:7968354, PMID:8281324, PMID:21787676, PMID:21971501 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Ghrl ghrelin multiple interactions ISO Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein] CTD PMID:16959836 NCBI chr 6:113,716,119...113,719,911
Ensembl chr 6:113,716,119...113,719,880
JBrowse link
G Glra1 glycine receptor, alpha 1 subunit multiple interactions ISO Atropine binds to and results in decreased activity of GLRA1 protein CTD PMID:15081878 NCBI chr11:55,514,239...55,608,198
Ensembl chr11:55,514,238...55,608,198
JBrowse link
G Grm4 glutamate receptor, metabotropic 4 multiple interactions ISO Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr17:27,422,387...27,513,826
Ensembl chr17:27,422,387...27,521,403
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 protein] CTD PMID:22245128 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B protein] CTD PMID:22245128 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 mRNA]; [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 protein] CTD PMID:22245128 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Jun jun proto-oncogene multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of JUN protein] CTD PMID:21971501 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Junb jun B proto-oncogene multiple interactions ISO Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] CTD PMID:7968354 NCBI chr 8:84,976,909...84,978,748
Ensembl chr 8:84,974,484...84,978,718
Ensembl chr 8:84,974,484...84,978,718
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr 2:55,411,798...55,598,145
Ensembl chr 2:55,435,970...55,598,145
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of KIT protein] CTD PMID:17390078 NCBI chr 5:75,574,987...75,656,722
Ensembl chr 5:75,574,916...75,656,722
JBrowse link
G Ltf lactotransferrin multiple interactions ISO Atropine inhibits the reaction [methylcholine results in increased secretion of LTF protein] CTD PMID:11112886 NCBI chr 9:111,019,292...111,042,766
Ensembl chr 9:111,019,271...111,042,767
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK1 protein] CTD PMID:21971501 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK14 protein] CTD PMID:21971501 NCBI chr17:28,691,342...28,748,405
Ensembl chr17:28,691,329...28,748,406
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK3 protein] CTD PMID:21971501 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK8 protein] CTD PMID:21971501 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 multiple interactions
increases expression
ISO [Parathion co-treated with Atropine] results in increased expression of MCM4 mRNA
Atropine results in increased expression of MCM4 mRNA
CTD PMID:17390078 NCBI chr16:15,623,897...15,637,400
Ensembl chr16:15,623,897...15,637,400
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 increases expression
multiple interactions
ISO Atropine results in increased expression of MCM6 mRNA
[Parathion co-treated with Atropine] results in increased expression of MCM6 mRNA
CTD PMID:17390078 NCBI chr 1:128,331,575...128,359,705
Ensembl chr 1:128,331,590...128,359,664
JBrowse link
G Nefh neurofilament, heavy polypeptide affects expression ISO Atropine affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr11:4,938,754...4,948,064
Ensembl chr11:4,938,754...4,948,064
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression ISO Atropine results in increased expression of NLRP3 mRNA CTD PMID:28138970 NCBI chr11:59,541,569...59,566,955
Ensembl chr11:59,541,568...59,566,956
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Atropine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Atropine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] CTD PMID:15610444, PMID:16944022 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Notch4 notch 4 multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of NOTCH4 protein] CTD PMID:17390078 NCBI chr17:34,564,286...34,588,543
Ensembl chr17:34,564,268...34,588,503
JBrowse link
G Nppa natriuretic peptide type A affects activity ISO Atropine affects the activity of NPPA protein modified form CTD PMID:1363893 NCBI chr 4:148,000,722...148,002,074
Ensembl chr 4:148,000,722...148,002,079
JBrowse link
G Oprl1 opioid receptor-like 1 multiple interactions ISO Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] CTD PMID:12007927 NCBI chr 2:181,715,000...181,720,985
Ensembl chr 2:181,715,016...181,720,985
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Atropine inhibits the reaction [Malathion results in increased expression of PCNA]; Atropine inhibits the reaction [Parathion results in increased expression of PCNA] CTD PMID:12762645 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Pnoc prepronociceptin multiple interactions ISO Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] CTD PMID:12007927 NCBI chr14:65,400,673...65,425,564
Ensembl chr14:65,400,673...65,425,472
JBrowse link
G Pomc pro-opiomelanocortin-alpha multiple interactions ISO Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein] CTD PMID:7588217 NCBI chr12:3,954,945...3,960,643
Ensembl chr12:3,954,951...3,960,642
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [Atropine co-treated with Glucose] binds to PPARA protein; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Atropine affects the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA] CTD PMID:15104355, PMID:15610444, PMID:16259740, PMID:16804302 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Ptk2 PTK2 protein tyrosine kinase 2 multiple interactions ISO Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]] CTD PMID:10537051 NCBI chr15:73,205,102...73,423,820
Ensembl chr15:73,205,102...73,423,280
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G Pxn paxillin multiple interactions ISO Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]] CTD PMID:10537051 NCBI chr 5:115,491,970...115,555,987
Ensembl chr 5:115,506,676...115,555,987
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G Rac3 Rac family small GTPase 3 multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of RAC3 protein] CTD PMID:17390078 NCBI chr11:120,721,468...120,723,969
Ensembl chr11:120,721,470...120,723,969
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G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of RELA protein] CTD PMID:21971501 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
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G Rhoa ras homolog family member A multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of RHOA protein] CTD PMID:17390078 NCBI chr 9:108,306,160...108,337,943
Ensembl chr 9:108,306,129...108,337,934
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G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 multiple interactions ISO Atropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091, PMID:21641380 NCBI chr17:12,648,874...12,675,838
Ensembl chr17:12,648,869...12,675,829
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G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Atropine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:16263091, PMID:21599003, PMID:23770354 NCBI chr17:12,584,189...12,628,489
Ensembl chr17:12,584,132...12,628,488
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G Slc22a3 solute carrier family 22 (organic cation transporter), member 3 increases uptake
multiple interactions
ISO SLC22A3 protein results in increased uptake of Atropine
Atropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]
CTD PMID:16263091 NCBI chr17:12,419,972...12,507,704
Ensembl chr17:12,418,960...12,507,704
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G Slc22a4 solute carrier family 22 (organic cation transporter), member 4 multiple interactions ISO Atropine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] CTD PMID:21641380 NCBI chr11:53,983,115...54,030,040
Ensembl chr11:53,983,123...54,028,090
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G Slc47a1 solute carrier family 47, member 1 multiple interactions ISO Atropine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr11:61,343,400...61,378,842
Ensembl chr11:61,343,401...61,378,345
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G Slc47a2 solute carrier family 47, member 2 multiple interactions ISO Atropine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr11:61,301,627...61,342,860
Ensembl chr11:61,301,631...61,342,860
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G Socs3 suppressor of cytokine signaling 3 multiple interactions EXP [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of SOCS3 mRNA] CTD PMID:22245128 NCBI chr11:117,966,079...117,970,336
Ensembl chr11:117,966,079...117,970,047
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G Spn sialophorin increases response to substance EXP SPN protein results in increased susceptibility to Atropine CTD PMID:18711009 NCBI chr 7:127,123,637...127,145,552
Ensembl chr 7:127,132,232...127,137,823
JBrowse link
G Tat tyrosine aminotransferase multiple interactions ISO [Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein] CTD PMID:7761789 NCBI chr 8:109,986,078...109,999,804
Ensembl chr 8:109,990,437...109,999,803
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] CTD PMID:18472332 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF protein] CTD PMID:22245128 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007