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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:anti-arrhythmia drug
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Accession:CHEBI:38070 term browser browse the term
Definition:A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
Synonyms:related_synonym: anti-arrhythmia agent;   antiarrhythmic agent


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(S)-timolol (anhydrous) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 multiple interactions EXP Timolol binds to and results in decreased activity of ADRB1 protein; Timolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP] CTD PMID:11436944 PMID:15060759 NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904
JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions EXP [Timolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; Timolol binds to and results in decreased activity of ADRB2 protein CTD PMID:11436944 PMID:17925438 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,825,245...148,828,687
JBrowse link
G AOC1 amine oxidase copper containing 1 multiple interactions ISO Timolol inhibits the reaction [Epinephrine results in increased activity of AOC1 protein] CTD PMID:2860926 NCBI chr 7:150,824,875...150,861,504
Ensembl chr 7:150,824,627...150,861,504
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 affects response to substance EXP CYP2D6 gene SNP affects the susceptibility to Timolol CTD PMID:19284319 PMID:20925579 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP
ISO
[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; [Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased phosphorylation of MAPK1 protein]; Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Gadolinium inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; W 7 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]
CTD PMID:11914123 PMID:18977218 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP
ISO
[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; [Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased phosphorylation of MAPK3 protein]; Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Gadolinium inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; W 7 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]
CTD PMID:11914123 PMID:18977218 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G RGS3 regulator of G protein signaling 3 multiple interactions EXP RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18977218 NCBI chr 9:113,444,730...113,597,743
Ensembl chr 9:113,444,731...113,597,743
JBrowse link
G RGS4 regulator of G protein signaling 4 multiple interactions EXP RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18977218 NCBI chr 1:163,068,871...163,076,802
Ensembl chr 1:163,068,775...163,076,802
JBrowse link
2-(4-hydroxyphenyl)ethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6PC1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO 4-hydroxyphenylethanol inhibits the reaction [Streptozocin results in increased activity of G6PC protein] CTD PMID:25641191 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions ISO 4-hydroxyphenylethanol inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] CTD PMID:25641191 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 4-hydroxyphenylethanol inhibits the reaction [[Lipids results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone] CTD PMID:18081942 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
3'-phospho-5'-adenylyl sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NAT2 N-acetyltransferase 2 multiple interactions EXP [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone] CTD PMID:20545351 NCBI chr 8:18,386,585...18,401,219
Ensembl chr 8:18,391,282...18,401,218
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [NQO1 protein co-treated with NADP co-treated with Phosphoadenosine Phosphosulfate co-treated with SULT1A1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone CTD PMID:20545351 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G P2RY1 purinergic receptor P2Y1 decreases activity EXP Phosphoadenosine Phosphosulfate results in decreased activity of P2RY1 protein CTD PMID:22273509 NCBI chr 3:152,835,131...152,841,439
Ensembl chr 3:152,835,131...152,841,439
JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 multiple interactions
increases sulfation
EXP 2,2',3,4,4',5',6-heptabromodiphenyl ether inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; [NQO1 protein co-treated with NADP co-treated with Phosphoadenosine Phosphosulfate co-treated with SULT1A1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; Halogenated Diphenyl Ethers analog inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; pentabrominated diphenyl ether 100 inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; Pentachlorophenol inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; tetrabromobisphenol A inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; tribromodiphenyl ether 28 inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]
SULT1A1 protein results in increased sulfation of Phosphoadenosine Phosphosulfate
CTD PMID:11425650 PMID:16601080 PMID:20545351 NCBI chr16:28,605,587...28,623,395
Ensembl chr16:28,605,196...28,623,625
JBrowse link
G SULT1A2 sulfotransferase family 1A member 2 multiple interactions EXP [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone] CTD PMID:20545351 NCBI chr16:28,591,943...28,597,070
Ensembl chr16:28,591,943...28,597,050
JBrowse link
G SULT1A3 sulfotransferase family 1A member 3 increases sulfation EXP SULT1A3 protein results in increased sulfation of Phosphoadenosine Phosphosulfate CTD PMID:11425650 NCBI chr16:30,199,255...30,204,310
Ensembl chr16:30,199,228...30,204,310
JBrowse link
G SULT2A1 sulfotransferase family 2A member 1 multiple interactions EXP [Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol; Celecoxib affects the reaction [[Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol]; SULT2A1 protein affects the metabolism of [Phosphoadenosine Phosphosulfate co-treated with Ethinyl Estradiol] CTD PMID:15483193 NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315
JBrowse link
3-iodobenzyl-5'-N-methylcarboxamidoadenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA3 adenosine A3 receptor multiple interactions ISO 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]
[N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Dizocilpine Maleate; [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Scopolamine; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein
CTD PMID:12672554 PMID:15452191 PMID:19966059 NCBI chr 1:111,499,429...111,503,633
Ensembl chr 1:111,499,429...111,503,633
Ensembl chr 1:111,499,429...111,503,633
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP Pertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in increased phosphorylation of AKT1 protein] CTD PMID:16116186 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 decreases expression
decreases response to substance
EXP N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of BIRC3 mRNA
BIRC3 protein results in decreased susceptibility to N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine
CTD PMID:16088125 NCBI chr11:102,317,373...102,339,403
Ensembl chr11:102,317,450...102,339,403
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 decreases response to substance EXP BIRC5 protein results in decreased susceptibility to N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine CTD PMID:16088125 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA] CTD PMID:15452191 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G IL12A interleukin 12A multiple interactions EXP N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]; Pertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]; wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]] CTD PMID:16116186 NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019
JBrowse link
G IL12B interleukin 12B multiple interactions EXP N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]; Pertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]; wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]] CTD PMID:16116186 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
JBrowse link
G NAIP NLR family apoptosis inhibitory protein decreases expression
decreases response to substance
EXP N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of NAIP mRNA
NAIP protein results in decreased susceptibility to N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine
CTD PMID:16088125 NCBI chr 5:70,968,166...71,025,339
Ensembl chr 5:70,968,483...71,025,114
Ensembl chr 5:70,968,483...71,025,114
JBrowse link
G NPPA natriuretic peptide A multiple interactions ISO 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:15452191 PMID:19966059 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G RGS2 regulator of G protein signaling 2 multiple interactions ISO N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA] CTD PMID:15452191 NCBI chr 1:192,809,039...192,812,275
Ensembl chr 1:192,809,039...192,812,275
JBrowse link
G SLC9A1 solute carrier family 9 member A1 multiple interactions ISO N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein] CTD PMID:15452191 NCBI chr 1:27,098,809...27,155,125
Ensembl chr 1:27,098,809...27,166,981
JBrowse link
5'-S-methyl-5'-thioadenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COL1A1 collagen type I alpha 1 chain decreases expression EXP 5'-methylthioadenosine results in decreased expression of COL1A1 mRNA CTD PMID:15983038 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,183,289...50,201,632
Ensembl chr17:50,183,289...50,201,632
JBrowse link
G COL1A2 collagen type I alpha 2 chain decreases expression EXP 5'-methylthioadenosine results in decreased expression of COL1A2 mRNA CTD PMID:15983038 NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 5'-methylthioadenosine] CTD PMID:27469509 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,504
Ensembl chr15:90,083,045...90,102,504
JBrowse link
G IFNG interferon gamma multiple interactions ISO 5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IFNG mRNA] CTD PMID:17080400 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO 5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA] CTD PMID:17080400 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 multiple interactions ISO 5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL2 mRNA] CTD PMID:17080400 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL6 interleukin 6 multiple interactions ISO 5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA] CTD PMID:17080400 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G LTB lymphotoxin beta multiple interactions ISO 5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of LTB mRNA] CTD PMID:17080400 NCBI chr 6:31,580,558...31,582,425
Ensembl chr 6:31,580,525...31,582,522
JBrowse link
acebutolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 multiple interactions
increases activity
EXP [Acebutolol co-treated with ADRB1] results in increased abundance of Cyclic AMP; CGP 20712A inhibits the reaction [[Acebutolol co-treated with ADRB1] results in increased abundance of Cyclic AMP]; CGP 20712A inhibits the reaction [Acebutolol results in increased activity of ADRB1 protein] CTD PMID:12761341 NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904
JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions EXP [Acebutolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,825,245...148,828,687
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Acebutolol results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP [Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein CTD PMID:17925438 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP [Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G REN renin decreases activity EXP
ISO
Acebutolol results in decreased activity of REN protein CTD PMID:6110712 PMID:6118215 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324
JBrowse link
acetoacetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSD17B2 hydroxysteroid 17-beta dehydrogenase 2 affects binding EXP acetoacetyl CoA binds to HSD17B2 protein CTD PMID:25526675 NCBI chr16:82,035,253...82,098,534
Ensembl chr16:82,035,004...82,098,534
JBrowse link
acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACLY ATP citrate lyase increases abundance ISO ACLY protein results in increased abundance of Acetyl Coenzyme A CTD PMID:28077572 NCBI chr17:41,866,916...41,930,542
Ensembl chr17:41,866,917...41,930,542
JBrowse link
G APP amyloid beta precursor protein affects localization
increases secretion
multiple interactions
ISO
EXP
APP protein affects the localization of Acetyl Coenzyme A
Acetyl Coenzyme A results in increased secretion of APP protein modified form
Acetyl Coenzyme A inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified form]
IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A]
CTD PMID:16122837 PMID:22906069 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G CRAT carnitine O-acetyltransferase decreases activity ISO Acetyl Coenzyme A deficiency results in decreased activity of CRAT protein CTD PMID:8075222 NCBI chr 9:129,094,794...129,110,793
Ensembl chr 9:129,094,794...129,111,189
JBrowse link
G ERCC6 ERCC excision repair 6, chromatin remodeling factor decreases abundance
multiple interactions
EXP ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A
3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]
CTD PMID:25440059 NCBI chr10:49,434,881...49,539,538
Ensembl chr10:49,454,470...49,539,538
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A] CTD PMID:16122837 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G KAT2B lysine acetyltransferase 2B affects binding ISO Acetyl Coenzyme A binds to KAT2B protein CTD PMID:28077572 NCBI chr 3:20,040,407...20,154,404
Ensembl chr 3:20,040,446...20,154,404
JBrowse link
G METRNL meteorin like, glial cell differentiation regulator multiple interactions ISO METRNL protein inhibits the reaction [Dietary Fats results in decreased abundance of Acetyl Coenzyme A] CTD PMID:30213948 NCBI chr17:83,079,609...83,095,122
Ensembl chr17:83,079,609...83,095,122
JBrowse link
G NAT1 N-acetyltransferase 1 multiple interactions
affects binding
EXP [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; Acetyl Coenzyme A inhibits the reaction [Cyanamide results in decreased activity of NAT1 protein]; Acetyl Coenzyme A inhibits the reaction [Iodoacetamide results in decreased activity of NAT1 protein]
Acetyl Coenzyme A binds to NAT1 protein
CTD PMID:20545351 PMID:22835378 NCBI chr 8:18,170,419...18,223,689
Ensembl chr 8:18,170,477...18,223,689
JBrowse link
G NAT2 N-acetyltransferase 2 multiple interactions EXP [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone] CTD PMID:20545351 NCBI chr 8:18,386,585...18,401,219
Ensembl chr 8:18,391,282...18,401,218
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone CTD PMID:20545351 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G SULT1A2 sulfotransferase family 1A member 2 multiple interactions EXP [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone] CTD PMID:20545351 NCBI chr16:28,591,943...28,597,070
Ensembl chr16:28,591,943...28,597,050
JBrowse link
acryloyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ECHS1 enoyl-CoA hydratase, short chain 1 increases abundance EXP ECHS1 gene mutant form results in increased abundance of acryloyl-coenzyme A CTD PMID:25125611 NCBI chr10:133,362,480...133,373,396
Ensembl chr10:133,362,485...133,373,354
JBrowse link
G HIBCH 3-hydroxyisobutyryl-CoA hydrolase increases abundance EXP HIBCH gene mutant form results in increased abundance of acryloyl-coenzyme A CTD PMID:25125611 NCBI chr 2:190,203,920...190,319,826
Ensembl chr 2:190,189,735...190,344,193
JBrowse link
acteoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions
decreases localization
EXP acteoside promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein]
acteoside results in decreased localization of AHR protein
CTD PMID:21756928 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G ARNT aryl hydrocarbon receptor nuclear translocator increases localization EXP acteoside results in increased localization of ARNT protein CTD PMID:21756928 NCBI chr 1:150,809,713...150,876,737
Ensembl chr 1:150,809,713...150,876,708
JBrowse link
G CCL2 C-C motif chemokine ligand 2 decreases secretion
multiple interactions
decreases expression
EXP acteoside results in decreased secretion of CCL2 protein
acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]
acteoside results in decreased expression of CCL2 mRNA
CTD PMID:21756928 PMID:21967610 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCND1 cyclin D1 decreases expression EXP acteoside results in decreased expression of CCND1 protein CTD PMID:17634406 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCND2 cyclin D2 decreases expression EXP acteoside results in decreased expression of CCND2 protein CTD PMID:17634406 NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353
Ensembl chr12:4,269,771...4,305,353
JBrowse link
G CCND3 cyclin D3 decreases expression EXP acteoside results in decreased expression of CCND3 protein CTD PMID:17634406 NCBI chr 6:41,934,933...42,048,894
Ensembl chr 6:41,934,933...42,050,357
Ensembl chr 6:41,934,933...42,050,357
JBrowse link
G CCNE1 cyclin E1 decreases expression EXP acteoside results in decreased expression of CCNE1 protein CTD PMID:17634406 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CDK2 cyclin dependent kinase 2 multiple interactions EXP acteoside results in decreased expression of and results in decreased activity of CDK2 protein CTD PMID:17634406 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G CDK4 cyclin dependent kinase 4 decreases activity
multiple interactions
EXP acteoside results in decreased activity of CDK4 protein
acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]
CTD PMID:17634406 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDK6 cyclin dependent kinase 6 multiple interactions EXP acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]; acteoside results in decreased expression of and results in decreased activity of CDK6 protein CTD PMID:17634406 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,594
Ensembl chr 7:92,604,921...92,836,594
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression
multiple interactions
EXP acteoside results in increased expression of CDKN1A mRNA; acteoside results in increased expression of CDKN1A protein
acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]
CTD PMID:17634406 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression
multiple interactions
EXP acteoside results in increased expression of CDKN1B mRNA; acteoside results in increased expression of CDKN1B protein
acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]
CTD PMID:17634406 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,715,058...12,722,369
JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 decreases secretion
decreases expression
multiple interactions
EXP acteoside results in decreased secretion of CXCL10 protein
acteoside results in decreased expression of CXCL10 mRNA
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [PD168393 results in increased secretion of CXCL10 protein]; acteoside promotes the reaction [leptomycin B results in decreased secretion of CXCL10 protein]
CTD PMID:21756928 PMID:21967610 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 decreases expression
decreases secretion
multiple interactions
EXP acteoside results in decreased expression of CXCL8 mRNA
acteoside results in decreased secretion of CXCL8 protein
[acteoside co-treated with TGFA protein] results in increased expression of CXCL8 mRNA; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]; acteoside inhibits the reaction [leptomycin B results in increased secretion of CXCL8 protein]; acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL8 mRNA]
CTD PMID:21371465 PMID:21756928 PMID:21967610 PMID:23527233 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression EXP acteoside results in increased expression of CYP1A1 mRNA CTD PMID:21756928 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions ISO acteoside inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein] CTD PMID:14672760 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G E2F1 E2F transcription factor 1 multiple interactions EXP [acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein] CTD PMID:17634406 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions
decreases phosphorylation
EXP acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein]
acteoside results in decreased phosphorylation of EGFR protein
CTD PMID:21756928 PMID:21967610 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G ICAM1 intercellular adhesion molecule 1 decreases expression EXP acteoside results in decreased expression of ICAM1 mRNA CTD PMID:21371465 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IFNG interferon gamma decreases expression
multiple interactions
EXP acteoside results in decreased expression of IFNG mRNA
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]
CTD PMID:21371465 PMID:21756928 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL6 interleukin 6 decreases expression
multiple interactions
EXP acteoside results in decreased expression of IL6 mRNA
acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]
CTD PMID:21756928 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ITGB2 integrin subunit beta 2 multiple interactions EXP acteoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]; acteoside inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein] CTD PMID:16393473 NCBI chr21:44,885,949...44,928,815
Ensembl chr21:44,885,953...44,931,989
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
EXP acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]
acteoside results in decreased phosphorylation of MAPK1 protein
acteoside results in increased phosphorylation of MAPK1 protein
CTD PMID:21756928 PMID:23527233 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation
multiple interactions
increases phosphorylation
EXP acteoside results in decreased phosphorylation of MAPK3 protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]
acteoside results in increased phosphorylation of MAPK3 protein
CTD PMID:21756928 PMID:23527233 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G NOX1 NADPH oxidase 1 decreases activity EXP acteoside results in decreased activity of NOX1 protein CTD PMID:16393473 NCBI chr  X:100,843,324...100,874,359
Ensembl chr  X:100,843,324...100,874,359
JBrowse link
G PTGDS prostaglandin D2 synthase affects binding EXP acteoside binds to PTGDS protein CTD PMID:26456343 NCBI chr 9:136,977,504...136,981,742
Ensembl chr 9:136,975,092...136,981,742
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [acteoside co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTGS2 mRNA CTD PMID:21756928 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RB1 RB transcriptional corepressor 1 decreases phosphorylation
multiple interactions
EXP acteoside results in decreased phosphorylation of RB1 protein
[acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein]
CTD PMID:17634406 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
decreases phosphorylation
increases phosphorylation
EXP acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
acteoside results in decreased phosphorylation of RELA protein
acteoside results in increased phosphorylation of RELA protein
CTD PMID:21756928 PMID:23527233 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G SMAD2 SMAD family member 2 increases phosphorylation EXP acteoside results in increased phosphorylation of SMAD2 protein CTD PMID:17634406 NCBI chr18:47,808,957...47,931,188
Ensembl chr18:47,808,957...47,931,146
JBrowse link
G SMAD3 SMAD family member 3 increases phosphorylation EXP acteoside results in increased phosphorylation of SMAD3 protein CTD PMID:17634406 NCBI chr15:67,065,602...67,195,195
Ensembl chr15:67,063,763...67,195,169
JBrowse link
G SOD2 superoxide dismutase 2 decreases expression EXP acteoside results in decreased expression of SOD2 mRNA CTD PMID:21371465 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G TGFA transforming growth factor alpha multiple interactions EXP [acteoside co-treated with TGFA protein] results in increased expression of CXCL8 mRNA; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein] CTD PMID:21756928 PMID:21967610 NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193
JBrowse link
G TGFB1 transforming growth factor beta 1 increases expression EXP acteoside results in increased expression of TGFB1 mRNA CTD PMID:17634406 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein] CTD PMID:21756928 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 decreases expression EXP acteoside results in decreased expression of VCAM1 mRNA CTD PMID:21371465 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045
JBrowse link
adenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase decreases metabolic processing
increases metabolic processing
EXP ADA alternative form results in decreased metabolism of Adenosine
ADA protein results in increased metabolism of Adenosine
CTD PMID:16221767 NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,619,522...44,652,233
JBrowse link
G ADORA1 adenosine A1 receptor multiple interactions
affects binding
EXP
ISO
Adenosine analog binds to and affects the activity of ADORA1 protein; Adenosine analog binds to and results in decreased activity of ADORA1 protein; PD 81723 affects the reaction [Adenosine analog binds to and affects the activity of ADORA1 protein]; VUF 5455 affects the reaction [Adenosine analog binds to and affects the activity of ADORA1 protein]
[lead acetate results in increased expression of ADORA1 protein] which results in increased abundance of Adenosine; Adenosine analog binds to and results in increased activity of ADORA1 protein
Adenosine binds to ADORA1 protein
CTD PMID:10649980 PMID:11520205 PMID:18404447 PMID:20571079 PMID:20932874 NCBI chr 1:203,127,705...203,167,405
Ensembl chr 1:203,090,654...203,167,405
JBrowse link
G ADORA2A adenosine A2a receptor multiple interactions
affects binding
EXP Adenosine analog binds to and results in decreased activity of ADORA2A protein; Adenosine promotes the reaction [Lipopolysaccharides results in increased expression of ADORA2A mRNA]
Adenosine binds to ADORA2A protein
CTD PMID:18404447 PMID:20067761 NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357
JBrowse link
G ADORA2B adenosine A2b receptor affects response to substance ISO ADORA2B protein affects the susceptibility to Adenosine CTD PMID:16920807 NCBI chr17:15,927,782...15,975,746
Ensembl chr17:15,944,917...15,975,746
JBrowse link
G ADORA3 adenosine A3 receptor multiple interactions
increases expression
affects binding
EXP Adenosine analog binds to and affects the activity of ADORA3 protein; Adenosine analog binds to and results in decreased activity of ADORA3 protein; Adenosine analog binds to and results in increased activity of ADORA3 protein; PD 81723 affects the reaction [Adenosine analog binds to and affects the activity of ADORA3 protein]; VUF 5455 affects the reaction [Adenosine analog binds to and affects the activity of ADORA3 protein]
Adenosine results in increased expression of ADORA3 mRNA
Adenosine binds to ADORA3 protein
CTD PMID:11520205 PMID:18404447 PMID:20067761 PMID:20571079 NCBI chr 1:111,499,429...111,503,633
Ensembl chr 1:111,499,429...111,503,633
Ensembl chr 1:111,499,429...111,503,633
JBrowse link
G ALPI alkaline phosphatase, intestinal multiple interactions EXP Adenosine inhibits the reaction [Methotrexate results in increased activity of ALPI protein] CTD PMID:16598758 NCBI chr 2:232,456,153...232,460,753
Ensembl chr 2:232,456,125...232,460,753
JBrowse link
G AMPD2 adenosine monophosphate deaminase 2 multiple interactions EXP [tofacitinib results in decreased expression of AMPD2 protein] which affects the abundance of Adenosine CTD PMID:25496463 NCBI chr 1:109,619,837...109,632,055
Ensembl chr 1:109,616,104...109,632,053
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases localization
multiple interactions
EXP Adenosine results in increased localization of BAX protein
Thymidine inhibits the reaction [Adenosine results in increased localization of BAX protein]
CTD PMID:11570579 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2L1 BCL2 like 1 decreases expression
multiple interactions
EXP Adenosine results in decreased expression of BCL2L1 mRNA; Adenosine results in decreased expression of BCL2L1 protein
Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 mRNA]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 protein]
CTD PMID:20063052 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 decreases expression EXP Adenosine results in decreased expression of BIRC2 mRNA; Adenosine results in decreased expression of BIRC2 protein CTD PMID:20063052 NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670
JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 decreases expression EXP Adenosine results in decreased expression of BIRC3 mRNA CTD PMID:20063052 NCBI chr11:102,317,373...102,339,403
Ensembl chr11:102,317,450...102,339,403
JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
EXP
ISO
Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP3 protein]; Thymidine inhibits the reaction [Adenosine results in increased activity of CASP3 protein] CTD PMID:11570579 PMID:16469385 PMID:17303086 PMID:20063052 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 increases activity
multiple interactions
EXP
ISO
Adenosine results in increased activity of CASP8 protein
Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP8 protein]
CTD PMID:16469385 PMID:17303086 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 increases activity
multiple interactions
EXP
ISO
Adenosine results in increased activity of CASP9 protein
Thymidine inhibits the reaction [Adenosine results in increased activity of CASP9 protein]
CTD PMID:11570579 PMID:16469385 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CD14 CD14 molecule increases expression EXP Adenosine results in increased expression of CD14 mRNA CTD PMID:21538184 NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,701
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator decreases expression
multiple interactions
EXP Adenosine results in decreased expression of CFLAR mRNA; Adenosine results in decreased expression of CFLAR mRNA alternative form; Adenosine results in decreased expression of CFLAR protein
Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA alternative form]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR protein]
CTD PMID:17303086 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687
JBrowse link
G CFTR CF transmembrane conductance regulator increases activity
multiple interactions
EXP Adenosine results in increased activity of CFTR protein
[Isoproterenol co-treated with Adenosine] results in increased activity of CFTR protein
CTD PMID:15039139 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; [Adenosine co-treated with Homocysteine] results in decreased expression of CXCL8 mRNA CTD PMID:24224954 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G DIABLO diablo IAP-binding mitochondrial protein increases expression
multiple interactions
EXP Adenosine results in increased expression of DIABLO mRNA; Adenosine results in increased expression of DIABLO protein
Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO mRNA]; Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO protein]
CTD PMID:20063052 NCBI chr12:122,207,662...122,227,456
Ensembl chr12:122,207,663...122,227,456
Ensembl chr12:122,207,663...122,227,456
JBrowse link
G DPP4 dipeptidyl peptidase 4 decreases expression
multiple interactions
EXP Adenosine results in decreased expression of DPP4 mRNA; Adenosine results in decreased expression of DPP4 protein
[Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 mRNA; [Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 protein; [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 mRNA; [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 protein
CTD PMID:16611738 NCBI chr 2:161,992,245...162,074,215
Ensembl chr 2:161,992,245...162,074,215
JBrowse link
G FADD Fas associated via death domain decreases expression
multiple interactions
EXP Adenosine results in decreased expression of FADD mRNA
Dipyridamole inhibits the reaction [Adenosine results in decreased expression of FADD mRNA]
CTD PMID:17303086 NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,163...70,207,390
Ensembl chr11:70,203,163...70,207,390
JBrowse link
G FASLG Fas ligand increases expression
multiple interactions
EXP
ISO
Adenosine results in increased expression of FASLG protein
[Adenosine co-treated with Coformycin] results in decreased expression of FASL mRNA
CTD PMID:11992407 PMID:16419169 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G GZMB granzyme B multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of GZMB mRNA CTD PMID:11992407 NCBI chr14:24,630,954...24,634,190
Ensembl chr14:24,630,954...24,634,267
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha increases expression EXP Adenosine results in increased expression of HIF1A mRNA CTD PMID:20067761 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Adenosine] CTD PMID:27469509 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,504
Ensembl chr15:90,083,045...90,102,504
JBrowse link
G IFNG interferon gamma multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of IFNG protein CTD PMID:11992407 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL10 interleukin 10 multiple interactions
increases expression
ISO Adenosine promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
Adenosine results in increased expression of IL10 mRNA; Adenosine results in increased expression of IL10 protein
CTD PMID:11023991 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL12B interleukin 12B decreases expression
multiple interactions
ISO Adenosine results in decreased expression of IL12B protein
Adenosine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]
CTD PMID:11023991 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO Adenosine inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Adenosine inhibits the reaction [IL1B protein results in increased expression of IL1R1]; Adenosine inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Adenosine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein] CTD PMID:24878381 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL1R1 interleukin 1 receptor type 1 multiple interactions ISO Adenosine inhibits the reaction [IL1B protein results in increased expression of IL1R1] CTD PMID:24878381 NCBI chr 2:102,069,638...102,179,874
Ensembl chr 2:102,064,544...102,179,874
JBrowse link
G IL2 interleukin 2 multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of IL2 protein CTD PMID:11992407 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G LY96 lymphocyte antigen 96 increases expression EXP Adenosine results in increased expression of LY96 mRNA CTD PMID:21538184 NCBI chr 8:73,991,275...74,099,807
Ensembl chr 8:73,991,392...74,029,079
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
decreases phosphorylation
EXP [Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 mRNA; [Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 protein CTD PMID:16611738 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation
multiple interactions
EXP Adenosine results in decreased phosphorylation of MAPK3 protein
[Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 mRNA; [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 protein
CTD PMID:16611738 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions
EXP Adenosine results in decreased expression of MYC protein
Thymidine inhibits the reaction [Adenosine results in decreased expression of MYC protein]; Uridine inhibits the reaction [Adenosine results in decreased expression of MYC protein]
CTD PMID:9808420 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Adenosine co-treated with Homocysteine] results in decreased expression of NFKBIA mRNA CTD PMID:24224954 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NOS2 nitric oxide synthase 2 decreases stability
multiple interactions
ISO Adenosine results in decreased stability of NOS2 mRNA
Adenosine inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Adenosine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]
CTD PMID:24878381 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NT5E 5'-nucleotidase ecto multiple interactions ISO [alpha,beta-methyleneadenosine 5'-diphosphate results in decreased activity of NT5E protein] inhibits the reaction [Oxygen deficiency results in increased abundance of Adenosine] CTD PMID:23437309 NCBI chr 6:85,450,083...85,495,784
Ensembl chr 6:85,449,584...85,495,791
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha increases expression EXP Adenosine results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PRF1 perforin 1 multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of PRF1 mRNA CTD PMID:11992407 NCBI chr10:70,597,348...70,602,741
Ensembl chr10:70,597,348...70,602,759
JBrowse link
G PTGDR prostaglandin D2 receptor multiple interactions ISO [Prostaglandin D2 results in increased activity of PTGDR protein] which results in increased metabolism of Adenosine; [Prostaglandin D2 results in increased activity of PTGDR protein] which results in increased secretion of Adenosine CTD PMID:11562489 NCBI chr14:52,267,256...52,276,724
Ensembl chr14:52,267,698...52,276,724
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein affects the localization of RELA protein modified form]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of RELA protein] CTD PMID:24224954 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G REN renin decreases secretion ISO Adenosine results in decreased secretion of REN protein CTD PMID:3044993 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324
JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 multiple interactions EXP [Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein CTD PMID:24224954 NCBI chr 6:3,063,967...3,115,187
Ensembl chr 6:3,063,991...3,115,187
JBrowse link
G SLC28A1 solute carrier family 28 member 1 affects transport
multiple interactions
EXP SLC28A1 protein affects the transport of Adenosine
Adenosine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]
CTD PMID:9124315 NCBI chr15:84,884,350...84,975,649
Ensembl chr15:84,884,654...84,945,798
JBrowse link
G SLC28A2 solute carrier family 28 member 2 increases transport EXP SLC28A2 protein results in increased transport of Adenosine CTD PMID:10087507 NCBI chr15:45,252,234...45,277,846
Ensembl chr15:45,252,234...45,277,846
JBrowse link
G SLC29A1 solute carrier family 29 member 1 (Augustine blood group) multiple interactions
increases uptake
affects abundance
ISO
EXP
4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]; 4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; [4-nitrobenzylthioinosine results in decreased activity of SLC29A1 protein] inhibits the reaction [Oxygen deficiency results in increased abundance of Adenosine]; [SLC29A1 co-treated with Oxygen deficiency] affects the abundance of Adenosine; Dipyridamole inhibits the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Dipyridamole promotes the reaction [[SLC29A1 co-treated with Oxygen deficiency] affects the abundance of Adenosine]
SLC29A1 protein alternative form results in increased uptake of Adenosine; SLC29A1 protein results in increased uptake of Adenosine
Cilostazol inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; draflazine inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Ethanol promotes the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]; Ethanol promotes the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Ticagrelor inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]
Adenosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]
SLC29A1 affects the abundance of Adenosine
CTD PMID:9353301 PMID:9396714 PMID:11179696 PMID:21283641 PMID:21872611 PMID:23437309 PMID:28041785 NCBI chr 6:44,219,587...44,234,144
Ensembl chr 6:44,219,553...44,234,142
Ensembl chr 6:44,219,553...44,234,142
JBrowse link
G SLC29A2 solute carrier family 29 member 2 increases uptake EXP SLC29A2 protein results in increased uptake of Adenosine CTD PMID:9396714 NCBI chr11:66,362,521...66,372,476
Ensembl chr11:66,362,521...66,372,214
JBrowse link
G SLC29A3 solute carrier family 29 member 3 affects transport EXP SLC29A3 protein affects the transport of Adenosine CTD PMID:19164483 NCBI chr10:71,319,259...71,363,387
Ensembl chr10:71,319,259...71,381,423
JBrowse link
G SLC5A5 solute carrier family 5 member 5 increases expression ISO Adenosine results in increased expression of SLC5A5 mRNA; Adenosine results in increased expression of SLC5A5 protein CTD PMID:16954431 NCBI chr19:17,871,394...17,895,175
Ensembl chr19:17,871,945...17,895,174
JBrowse link
G TLR4 toll like receptor 4 increases expression
affects localization
multiple interactions
EXP Adenosine results in increased expression of TLR4 mRNA
Adenosine affects the localization of TLR4 protein
Adenosine promotes the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of TLR4 protein]
CTD PMID:21538184 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine inhibits the reaction [Adenosine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]; [Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein affects the localization of RELA protein modified form]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of RELA protein]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; [Adenosine co-treated with Homocysteine] results in increased susceptibility to TNF protein; Adenosine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF mRNA]; Adenosine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]; ZM 241385 inhibits the reaction [Adenosine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]
Adenosine results in decreased expression of TNF protein
CTD PMID:11023991 PMID:21538184 PMID:24224954 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFAIP3 TNF alpha induced protein 3 multiple interactions EXP [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; [Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 mRNA; [Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 protein CTD PMID:24224954 NCBI chr 6:137,866,317...137,883,312
Ensembl chr 6:137,867,214...137,883,312
JBrowse link
G TNFSF10 TNF superfamily member 10 multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of TNFSF10 mRNA CTD PMID:11992407 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475
JBrowse link
G UPP1 uridine phosphorylase 1 increases metabolic processing ISO UPP1 protein results in increased metabolism of Adenosine CTD PMID:15772079 NCBI chr 7:48,088,308...48,108,736
Ensembl chr 7:48,088,628...48,108,736
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions
increases expression
increases secretion
EXP Adenosine promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]
Adenosine results in increased expression of VEGFA mRNA
Adenosine results in increased secretion of VEGFA protein
CTD PMID:20067761 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
adenosine 3',5'-bismonophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SULT1A1 sulfotransferase family 1A member 1 multiple interactions ISO Glutathione Disulfide affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]; Glutathione Disulfide affects the reaction [Polychlorinated Biphenyls analog affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]]; Polychlorinated Biphenyls analog affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein] CTD PMID:21130751 NCBI chr16:28,605,587...28,623,395
Ensembl chr16:28,605,196...28,623,625
JBrowse link
G SULT1E1 sulfotransferase family 1E member 1 multiple interactions EXP [2,2',4,4'-tetrabromodiphenyl ether metabolite co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein; [Estradiol co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein; [tetrabromobisphenol A co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein; Estradiol inhibits the reaction [[tetrabromobisphenol A co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein]; tetrabromobisphenol A inhibits the reaction [[Estradiol co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein] CTD PMID:23959441 NCBI chr 4:69,841,212...69,860,151
Ensembl chr 4:69,841,212...69,860,145
JBrowse link
G SULT2A1 sulfotransferase family 2A member 1 affects binding
multiple interactions
EXP adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein
Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]; Dehydroepiandrosterone inhibits the reaction [Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]]
CTD PMID:24059442 NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315
JBrowse link
adenosine 5'-(hexahydrogen pentaphosphate) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NUDT10 nudix hydrolase 10 multiple interactions EXP [NUDT10 protein results in increased metabolism of diadenosine 5',5''''-P1,P6-hexaphosphate] which results in increased chemical synthesis of adenosine 5'-pentaphosphate CTD PMID:12121577 NCBI chr  X:51,332,231...51,337,525
Ensembl chr  X:51,332,231...51,337,525
JBrowse link
G NUDT11 nudix hydrolase 11 multiple interactions EXP [NUDT11 protein results in increased metabolism of diadenosine 5',5''''-P1,P6-hexaphosphate] which results in increased chemical synthesis of adenosine 5'-pentaphosphate CTD PMID:12121577 NCBI chr  X:51,490,011...51,496,592
Ensembl chr  X:51,490,011...51,496,592
JBrowse link
adenosine 5'-[gamma-thio]triphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD80 CD80 molecule increases expression ISO adenosine 5'-O-(3-thiotriphosphate) results in increased expression of CD80 protein CTD PMID:15944274 NCBI chr 3:119,524,293...119,559,614
Ensembl chr 3:119,524,293...119,559,614
JBrowse link
G CD86 CD86 molecule increases expression ISO adenosine 5'-O-(3-thiotriphosphate) results in increased expression of CD86 protein CTD PMID:15944274 NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP [adenosine 5'-O-(3-thiotriphosphate) binds to and results in increased activity of P2RY11 protein] which results in increased expression of CXCL8 protein CTD PMID:19815812 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G IL10 interleukin 10 decreases expression ISO adenosine 5'-O-(3-thiotriphosphate) results in decreased expression of IL10 protein CTD PMID:15944274 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL12B interleukin 12B increases expression ISO adenosine 5'-O-(3-thiotriphosphate) results in increased expression of IL12B protein CTD PMID:15944274 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
JBrowse link
G IL1B interleukin 1 beta increases expression ISO adenosine 5'-O-(3-thiotriphosphate) results in increased expression of IL1B protein CTD PMID:15944274 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G P2RX7 purinergic receptor P2X 7 affects response to substance ISO P2RX7 protein affects the susceptibility to adenosine 5'-O-(3-thiotriphosphate) CTD PMID:12873706 NCBI chr12:121,132,819...121,188,032
Ensembl chr12:121,132,819...121,188,032
JBrowse link
G P2RY11 purinergic receptor P2Y11 multiple interactions EXP [adenosine 5'-O-(3-thiotriphosphate) binds to and results in increased activity of P2RY11 protein] which results in increased expression of CXCL8 protein; adenosine 5'-O-(3-thiotriphosphate) binds to and results in increased activity of P2RY11 protein CTD PMID:19815812 NCBI chr19:10,111,693...10,115,372
Ensembl chr19:10,111,693...10,115,372
JBrowse link
G PTGDR prostaglandin D2 receptor multiple interactions EXP adenosine 5'-O-(3-thiotriphosphate) inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] CTD PMID:9579725 NCBI chr14:52,267,256...52,276,724
Ensembl chr14:52,267,698...52,276,724
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 increases activity
multiple interactions
ISO adenosine 5'-O-(3-thiotriphosphate) results in increased activity of TRPV1 protein
Capsaicin promotes the reaction [adenosine 5'-O-(3-thiotriphosphate) results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [adenosine 5'-O-(3-thiotriphosphate) results in increased activity of TRPV1 protein]
CTD PMID:11140687 NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411
JBrowse link
adenosine 5'-monophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC9 ATP binding cassette subfamily C member 9 multiple interactions ISO Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]] CTD PMID:11390963 NCBI chr12:21,797,389...21,941,863
Ensembl chr12:21,797,401...21,942,529
JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 multiple interactions EXP [4-dimethylaminocinnamaldehyde co-treated with Adenosine Monophosphate] binds to ALDH1A1 protein CTD PMID:10609638 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442
JBrowse link
G ERCC6 ERCC excision repair 6, chromatin remodeling factor increases abundance ISO ERCC6 gene mutant form results in increased abundance of Adenosine Monophosphate CTD PMID:25440059 NCBI chr10:49,434,881...49,539,538
Ensembl chr10:49,454,470...49,539,538
JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 multiple interactions ISO Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]] CTD PMID:11390963 NCBI chr11:17,385,246...17,389,346
Ensembl chr11:17,385,859...17,389,331
JBrowse link
G NUDT10 nudix hydrolase 10 multiple interactions EXP [NUDT10 protein results in increased metabolism of diadenosine 5',5''''-P1,P6-hexaphosphate] which results in increased chemical synthesis of Adenosine Monophosphate; [NUDT10 protein results in increased metabolism of P(1),P(5)-di(adenosine-5'-)pentaphosphate] which results in increased chemical synthesis of Adenosine Monophosphate CTD PMID:12121577 NCBI chr  X:51,332,231...51,337,525
Ensembl chr  X:51,332,231...51,337,525
JBrowse link
G NUDT11 nudix hydrolase 11 multiple interactions EXP [NUDT11 protein results in increased metabolism of diadenosine 5',5''''-P1,P6-hexaphosphate] which results in increased chemical synthesis of Adenosine Monophosphate; [NUDT11 protein results in increased metabolism of P(1),P(5)-di(adenosine-5'-)pentaphosphate] which results in increased chemical synthesis of Adenosine Monophosphate CTD PMID:12121577 NCBI chr  X:51,490,011...51,496,592
Ensembl chr  X:51,490,011...51,496,592
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha increases expression EXP Adenosine Monophosphate results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G TP73 tumor protein p73 affects abundance ISO TP73 protein affects the abundance of Adenosine Monophosphate CTD PMID:25554796 NCBI chr 1:3,652,516...3,736,201
Ensembl chr 1:3,652,516...3,736,201
JBrowse link
ADP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 multiple interactions
affects binding
EXP estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein mutant form]; estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein]; Vanadates promotes the reaction [Adenosine Diphosphate binds to ABCC1 protein]
Adenosine Diphosphate binds to ABCC1 protein; Adenosine Diphosphate binds to ABCC1 protein mutant form
CTD PMID:18336795 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions ISO Adenosine Diphosphate affects the folding of [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:1848756 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AK1 adenylate kinase 1 increases abundance ISO AK1 protein results in increased abundance of Adenosine Diphosphate CTD PMID:11390963 NCBI chr 9:127,866,480...127,885,542
Ensembl chr 9:127,866,486...127,877,675
JBrowse link
G ALB albumin decreases secretion
multiple interactions
EXP Adenosine Diphosphate results in decreased secretion of ALB protein
Aspirin inhibits the reaction [Adenosine Diphosphate results in decreased secretion of ALB protein]
CTD PMID:17303692 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G AXL AXL receptor tyrosine kinase decreases response to substance EXP AXL protein results in decreased susceptibility to Adenosine Diphosphate CTD PMID:15733062 NCBI chr19:41,219,223...41,261,766
Ensembl chr19:41,219,223...41,261,766
JBrowse link
G CAT catalase multiple interactions ISO CAT protein inhibits the reaction [Adenosine Diphosphate results in increased glutathionylation of PTPN1 protein] CTD PMID:16781456 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CD40LG CD40 ligand increases expression
multiple interactions
EXP
ISO
Adenosine Diphosphate results in increased expression of CD40LG protein
clopidogrel inhibits the reaction [Adenosine Diphosphate results in increased expression of CD40LG protein]
CTD PMID:11297035 PMID:17043144 NCBI chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390
JBrowse link
G CFTR CF transmembrane conductance regulator multiple interactions EXP Adenosine Diphosphate binds to and results in decreased activity of CFTR protein; P(1),P(5)-di(adenosine-5'-)pentaphosphate inhibits the reaction [Adenosine Diphosphate binds to and results in decreased activity of CFTR protein] CTD PMID:15684079 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G CHORDC1 cysteine and histidine rich domain containing 1 multiple interactions ISO Adenosine Diphosphate binds to and affects the folding of CHORDC1 protein; Adenosine Diphosphate promotes the reaction [CHORDC1 protein binds to CHORDC1 protein]; Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to CHORDC1 protein] CTD PMID:23184943 NCBI chr11:90,200,429...90,223,082
Ensembl chr11:90,200,429...90,223,077
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 multiple interactions EXP CYP2C19 gene affects the susceptibility to [Adenosine Diphosphate co-treated with clopidogrel]; CYP2C19 gene SNP affects the reaction [Adenosine Diphosphate results in increased expression of SELP protein]; CYP2C19 gene SNP affects the susceptibility to [Adenosine Diphosphate co-treated with Arachidonic Acid] CTD PMID:16772608 PMID:18004210 PMID:18394438 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G DTYMK deoxythymidylate kinase multiple interactions EXP DTYMK protein binds to [N1-(4-bis(pivaloyloxymethyl)phosphinylbuten-2-yl)thymine co-treated with Adenosine Diphosphate] CTD PMID:21128666 NCBI chr 2:241,675,747...241,686,815
Ensembl chr 2:241,675,747...241,686,944
JBrowse link
G EPHA4 EPH receptor A4 increases phosphorylation
multiple interactions
EXP Adenosine Diphosphate results in increased phosphorylation of EPHA4 protein
Benzoic Acid analog inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of EPHA4 protein]
CTD PMID:22273509 NCBI chr 2:221,418,027...221,574,202
Ensembl chr 2:221,418,027...221,574,202
JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
decreases activity
ISO Adenosine Diphosphate inhibits the reaction [ERN1 protein binds to ERN1 protein]
Adenosine Diphosphate results in decreased activity of ERN1 protein
CTD PMID:25164867 NCBI chr17:64,039,142...64,132,469
Ensembl chr17:64,039,142...64,130,819
JBrowse link
G F2 coagulation factor II, thrombin increases abundance
multiple interactions
EXP F2 protein results in increased abundance of Adenosine Diphosphate
Quercetin inhibits the reaction [F2 protein results in increased abundance of Adenosine Diphosphate]; resveratrol inhibits the reaction [F2 protein results in increased abundance of Adenosine Diphosphate]
CTD PMID:15342215 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506
Ensembl chr11:46,719,196...46,739,506
JBrowse link
G FGA fibrinogen alpha chain multiple interactions
increases secretion
EXP Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGA protein] CTD PMID:17303692 NCBI chr 4:154,583,126...154,590,742
Ensembl chr 4:154,583,128...154,590,745
JBrowse link
G FGB fibrinogen beta chain decreases secretion
multiple interactions
EXP Adenosine Diphosphate results in decreased secretion of FGB protein
Aspirin inhibits the reaction [Adenosine Diphosphate results in decreased secretion of FGB protein]
CTD PMID:17303692 NCBI chr 4:154,562,980...154,572,807
Ensembl chr 4:154,563,011...154,572,807
Ensembl chr 4:154,563,011...154,572,807
JBrowse link
G FGG fibrinogen gamma chain increases secretion
multiple interactions
EXP Adenosine Diphosphate results in increased secretion of FGG protein
Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGG protein]
CTD PMID:17303692 NCBI chr 4:154,604,136...154,612,656
Ensembl chr 4:154,604,134...154,612,967
JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP Adenosine Diphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog] CTD PMID:15788719 NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374
JBrowse link
G GAS6 growth arrest specific 6 increases response to substance EXP GAS6 protein results in increased susceptibility to Adenosine Diphosphate CTD PMID:15733062 NCBI chr13:113,820,549...113,864,076
Ensembl chr13:113,820,549...113,864,076
JBrowse link
G HRAS HRas proto-oncogene, GTPase multiple interactions EXP Adenosine Diphosphate binds to and affects the folding of HRAS protein CTD PMID:16388579 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,287
JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]; Calcium promotes the reaction [Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]] CTD PMID:23184943 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,738...102,139,699
Ensembl chr14:102,080,738...102,139,699
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions
ISO IDH2 protein mutant form results in increased abundance of Adenosine Diphosphate
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Adenosine Diphosphate]
CTD PMID:27469509 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,504
Ensembl chr15:90,083,045...90,102,504
JBrowse link
G IL6 interleukin 6 increases expression
multiple interactions
ISO Adenosine Diphosphate results in increased expression of IL6 protein
MRS 2211 inhibits the reaction [Adenosine Diphosphate results in increased expression of IL6 protein]
CTD PMID:24849676 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ITGA2 integrin subunit alpha 2 multiple interactions EXP ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Adenosine Diphosphate] CTD PMID:16214444 NCBI chr 5:52,989,352...53,094,779
Ensembl chr 5:52,989,340...53,094,779
JBrowse link
G ITGA2B integrin subunit alpha 2b multiple interactions EXP cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]] CTD PMID:18404433 NCBI chr17:44,372,181...44,389,649
Ensembl chr17:44,372,180...44,389,649
JBrowse link
G ITGB1BP2 integrin subunit beta 1 binding protein 2 multiple interactions ISO Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to CHORDC1 protein]; Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]; Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to ITGB1BP2 protein]; Calcium promotes the reaction [Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]] CTD PMID:23184943 NCBI chr  X:71,301,750...71,305,371
Ensembl chr  X:71,301,750...71,305,371
JBrowse link
G ITGB3 integrin subunit beta 3 multiple interactions EXP cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]] CTD PMID:18404433 NCBI chr17:47,253,827...47,313,743
Ensembl chr17:47,253,846...47,313,735
Ensembl chr17:47,253,846...47,313,735
Ensembl chr17:47,253,846...47,313,735
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation EXP Adenosine Diphosphate results in increased phosphorylation of MAPK1 protein CTD PMID:15034929 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation EXP Adenosine Diphosphate results in increased phosphorylation of MAPK3 protein CTD PMID:15034929 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP Dicumarol inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of MAPK8 protein] CTD PMID:24466103 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP Dicumarol inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of MAPK9 protein] CTD PMID:24466103 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099
JBrowse link
G MERTK MER proto-oncogene, tyrosine kinase increases response to substance EXP MERTK protein results in increased susceptibility to Adenosine Diphosphate CTD PMID:15733062 NCBI chr 2:111,898,607...112,029,561
Ensembl chr 2:111,898,607...112,029,561
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Adenosine Diphosphate] CTD PMID:11498454 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NT5E 5'-nucleotidase ecto decreases activity EXP Adenosine Diphosphate analog results in decreased activity of NT5E protein CTD PMID:18404487 NCBI chr 6:85,450,083...85,495,784
Ensembl chr 6:85,449,584...85,495,791
JBrowse link
G P2RY12 purinergic receptor P2Y12 affects response to substance
increases response to substance
multiple interactions
EXP
ISO
P2RY12 gene polymorphism affects the susceptibility to Adenosine Diphosphate; P2RY12 protein affects the susceptibility to Adenosine Diphosphate
P2RY12 protein results in increased susceptibility to Adenosine Diphosphate
Epinephrine inhibits the reaction [P2RY12 gene mutant form results in decreased susceptibility to Adenosine Diphosphate]
P2RY12 protein affects the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]
CTD PMID:11196645 PMID:11413167 PMID:18404433 PMID:23849096 NCBI chr 3:151,336,843...151,384,753
Ensembl chr 3:151,337,380...151,384,812
Ensembl chr 3:151,337,380...151,384,812
JBrowse link
G PDGFB platelet derived growth factor subunit B increases secretion
multiple interactions
EXP Adenosine Diphosphate results in increased secretion of PDGFB protein
Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of PDGFB protein]
CTD PMID:17303692 NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982
JBrowse link
G PF4 platelet factor 4 increases secretion EXP Adenosine Diphosphate results in increased secretion of PF4 protein CTD PMID:19428933 NCBI chr 4:73,980,811...73,982,124
Ensembl chr 4:73,980,811...73,982,027
JBrowse link
G PFKM phosphofructokinase, muscle multiple interactions EXP Adenosine Diphosphate inhibits the reaction [resveratrol results in decreased activity of PFKM protein] CTD PMID:23454376 NCBI chr12:48,105,353...48,146,404
Ensembl chr12:48,105,139...48,146,404
JBrowse link
G PGP phosphoglycolate phosphatase decreases phosphorylation ISO PGP protein results in decreased phosphorylation of Adenosine Diphosphate CTD PMID:24338473 NCBI chr16:2,211,593...2,214,840
Ensembl chr16:2,211,593...2,214,840
JBrowse link
G PPBP pro-platelet basic protein increases secretion EXP Adenosine Diphosphate results in increased secretion of PPBP protein CTD PMID:19428933 NCBI chr 4:73,986,439...73,988,190
Ensembl chr 4:73,986,439...73,988,190
JBrowse link
G PPP5C protein phosphatase 5 catalytic subunit multiple interactions EXP Adenosine Diphosphate binds to and affects the folding of PPP5C protein CTD PMID:23184943 NCBI chr19:46,347,069...46,390,975
Ensembl chr19:46,347,087...46,392,981
JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 increases glutathionylation
multiple interactions
ISO Adenosine Diphosphate results in increased glutathionylation of PTPN1 protein
CAT protein inhibits the reaction [Adenosine Diphosphate results in increased glutathionylation of PTPN1 protein]
CTD PMID:16781456 NCBI chr20:50,510,383...50,585,241
Ensembl chr20:50,510,321...50,585,241
JBrowse link
G SELP selectin P multiple interactions
increases expression
EXP cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]; CYP2C19 gene SNP affects the reaction [Adenosine Diphosphate results in increased expression of SELP protein]; Heparin promotes the reaction [Adenosine Diphosphate affects the localization of SELP protein]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]]; P2RY12 protein affects the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]; Quercetin inhibits the reaction [Adenosine Diphosphate results in increased expression of SELP protein] CTD PMID:9740346 PMID:18394438 PMID:18404433 PMID:23249183 NCBI chr 1:169,588,849...169,630,125
Ensembl chr 1:169,588,849...169,630,193
JBrowse link
G SIRT3 sirtuin 3 decreases abundance ISO SIRT3 protein results in decreased abundance of Adenosine Diphosphate CTD PMID:23166782 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931
JBrowse link
G TALDO1 transaldolase 1 increases abundance ISO TALDO1 gene mutant form results in increased abundance of Adenosine Diphosphate CTD PMID:19436114 NCBI chr11:747,464...765,012
Ensembl chr11:747,415...765,012
JBrowse link
G THBS1 thrombospondin 1 increases secretion EXP Adenosine Diphosphate results in increased secretion of THBS1 protein CTD PMID:17303692 NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466
JBrowse link
G TYRO3 TYRO3 protein tyrosine kinase increases response to substance EXP TYRO3 protein results in increased susceptibility to Adenosine Diphosphate CTD PMID:15733062 NCBI chr15:41,559,212...41,583,589
Ensembl chr15:41,557,675...41,583,589
JBrowse link
G VASP vasodilator stimulated phosphoprotein multiple interactions
increases phosphorylation
EXP N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of VASP protein] CTD PMID:25329809 NCBI chr19:45,507,459...45,526,989
Ensembl chr19:45,506,579...45,526,983
JBrowse link
ADP-D-ribose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADPRH ADP-ribosylarginine hydrolase increases hydrolysis EXP ADPRH protein results in increased hydrolysis of Adenosine Diphosphate Ribose metabolite CTD PMID:21498885 NCBI chr 3:119,579,492...119,589,945
Ensembl chr 3:119,579,268...119,589,945
JBrowse link
G ADPRS ADP-ribosylserine hydrolase increases hydrolysis
multiple interactions
EXP ADPRS protein results in increased hydrolysis of Adenosine Diphosphate Ribose metabolite
Adenosine Diphosphate Ribose inhibits the reaction [ADPRS protein results in increased hydrolysis of O-Acetyl-ADP-Ribose]
CTD PMID:21498885 NCBI chr 1:36,088,885...36,093,932
Ensembl chr 1:36,088,892...36,093,932
JBrowse link
G NOS1 nitric oxide synthase 1 multiple interactions ISO NOS1 protein affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased ribosylation of Adenosine Diphosphate Ribose] CTD PMID:10318960 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170
JBrowse link
G TRPM2 transient receptor potential cation channel subfamily M member 2 multiple interactions
increases activity
ISO
EXP
Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]; Clotrimazole inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]; Flufenamic Acid inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]
Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein
2-aminoethoxydiphenyl borate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Copper Sulfate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; ferrous chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; lead nitrate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Mercuric Chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Miconazole inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Selenium Oxides inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]
TRPM2 protein promotes the reaction [Adenosine Diphosphate Ribose results in increased uptake of Calcium]
CTD PMID:18204483 PMID:20878536 PMID:21900507 PMID:22750002 NCBI chr21:44,350,112...44,442,807
Ensembl chr21:44,350,163...44,443,081
JBrowse link
alprenolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 multiple interactions
increases phosphorylation
increases activity
EXP [Alprenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Alprenolol binds to and results in decreased activity of ADRB1 protein; Alprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Alprenolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; Alprenolol promotes the reaction [ADRB1 protein binds to ARRB1 protein]; Alprenolol promotes the reaction [ADRB1 protein binds to ARRB2 protein]; Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; CGP 20712A affects the reaction [Alprenolol results in increased activity of ADRB1 protein]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]
[Alprenolol results in increased phosphorylation of ADRB1 protein] which results in increased phosphorylation of EGFR protein; Alprenolol results in increased phosphorylation of ADRB1 protein
CTD PMID:12761341 PMID:14730417 PMID:15060759 PMID:18787115 NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904
JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions EXP
ISO
[Alprenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Alprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Alprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Alprenolol co-treated with ADRB2 protein] results in increased expression of GNAS protein; Alprenolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]
Alprenolol inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]; Alprenolol inhibits the reaction [ADRB2 results in increased expression of GRK2 protein]
CTD PMID:10455254 PMID:12198331 PMID:14730417 PMID:17925438 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,825,245...148,828,687
JBrowse link
G ADRB3 adrenoceptor beta 3 multiple interactions EXP [Alprenolol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Alprenolol binds to and results in increased activity of ADRB3 protein; Alprenolol inhibits the reaction [cyanopindolol binds to ADRB3 protein] CTD PMID:14730417 NCBI chr 8:37,962,990...37,966,599
Ensembl chr 8:37,962,990...37,966,599
JBrowse link
G ARRB1 arrestin beta 1 multiple interactions EXP [Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR125A mRNA; [Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR125B-1 mRNA; [Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR150 mRNA; [Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR214 mRNA; Alprenolol promotes the reaction [ADRB1 protein binds to ARRB1 protein]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]] CTD PMID:18787115 PMID:24334028 NCBI chr11:75,260,122...75,351,662
Ensembl chr11:75,260,122...75,351,705
JBrowse link
G ARRB2 arrestin beta 2 multiple interactions EXP Alprenolol promotes the reaction [ADRB1 protein binds to ARRB2 protein]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]] CTD PMID:18787115 NCBI chr17:4,710,619...4,721,500
Ensembl chr17:4,710,596...4,721,499
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions
increases phosphorylation
EXP AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]
[Alprenolol results in increased phosphorylation of ADRB1 protein] which results in increased phosphorylation of EGFR protein
CTD PMID:18787115 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G GNAS GNAS complex locus multiple interactions EXP [Alprenolol co-treated with ADRB2 protein] results in increased expression of GNAS protein CTD PMID:10455254 NCBI chr20:58,839,681...58,911,192
Ensembl chr20:58,839,718...58,911,192
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 multiple interactions ISO Alprenolol inhibits the reaction [ADRB2 results in increased expression of GRK2 protein] CTD PMID:12198331 NCBI chr11:67,266,420...67,286,556
Ensembl chr11:67,266,473...67,286,556
JBrowse link
G HBEGF heparin binding EGF like growth factor multiple interactions EXP HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]] CTD PMID:18787115 NCBI chr 5:140,332,843...140,346,603
Ensembl chr 5:140,332,843...140,346,603
JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A multiple interactions ISO [Alprenolol co-treated with Cocaine] affects the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] CTD PMID:8392199 NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,550...46,897,076
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
[Alprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]
Erlotinib Hydrochloride inhibits the reaction [Alprenolol results in increased phosphorylation of MAPK1 protein]
CTD PMID:17925438 PMID:18787115 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
[Alprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]
Erlotinib Hydrochloride inhibits the reaction [Alprenolol results in increased phosphorylation of MAPK3 protein]
CTD PMID:17925438 PMID:18787115 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MIR125A microRNA 125a multiple interactions
increases expression
EXP
ISO
[Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR125A mRNA
Alprenolol results in increased expression of MIR125A mRNA
CTD PMID:24334028 NCBI chr19:51,693,254...51,693,339
Ensembl chr19:51,693,254...51,693,339
JBrowse link
G MIR125B1 microRNA 125b-1 multiple interactions
increases expression
EXP
ISO
[Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR125B-1 mRNA
Alprenolol results in increased expression of MIR125B-1 mRNA
CTD PMID:24334028 NCBI chr11:122,099,757...122,099,844
Ensembl chr11:122,099,757...122,099,844
JBrowse link
G MIR150 microRNA 150 multiple interactions
increases expression
EXP
ISO
[Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR150 mRNA
Alprenolol results in increased expression of MIR150 mRNA
CTD PMID:24334028 NCBI chr19:49,500,785...49,500,868
Ensembl chr19:49,500,785...49,500,868
JBrowse link
G MIR214 microRNA 214 multiple interactions
increases expression
EXP
ISO
[Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR214 mRNA
Alprenolol results in increased expression of MIR214 mRNA
CTD PMID:24334028 NCBI chr 1:172,138,798...172,138,907
Ensembl chr 1:172,138,798...172,138,907
JBrowse link
G NPPA natriuretic peptide A increases expression ISO Alprenolol results in increased expression of NPPA mRNA CTD PMID:12721106 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G ODC1 ornithine decarboxylase 1 multiple interactions ISO Alprenolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein] CTD PMID:10353628 NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327
JBrowse link
G REN renin multiple interactions
decreases expression
EXP Alprenolol inhibits the reaction [Hydralazine results in increased expression of REN protein]
Alprenolol results in decreased expression of REN protein
CTD PMID:923630 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Alprenolol inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
AMP-PNP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions ISO Adenylyl Imidodiphosphate affects the folding of [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:1848756 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G CFTR CF transmembrane conductance regulator affects activity EXP Adenylyl Imidodiphosphate affects the activity of CFTR protein CTD PMID:15657297 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G PTGDR prostaglandin D2 receptor multiple interactions EXP Adenylyl Imidodiphosphate inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] CTD PMID:9579725 NCBI chr14:52,267,256...52,276,724
Ensembl chr14:52,267,698...52,276,724
JBrowse link
arachidonoyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARA peroxisome proliferator activated receptor alpha multiple interactions EXP arachidonyl-coenzyme A binds to and results in increased activity of PPARA protein CTD PMID:11139385 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
atenolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
EXP Atenolol inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atenolol results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ADRA2A adrenoceptor alpha 2A affects response to substance EXP ADRA2A gene SNP affects the susceptibility to Atenolol CTD PMID:15614026 NCBI chr10:111,077,029...111,080,907
Ensembl chr10:111,077,029...111,080,907
JBrowse link
G ADRB1 adrenoceptor beta 1 decreases activity
multiple interactions
affects binding
affects response to substance
decreases expression
EXP
ISO
Atenolol results in decreased activity of ADRB1 protein
Atenolol binds to and results in decreased activity of ADRB1 protein; Atenolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Atenolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]
Atenolol binds to ADRB1 protein
[Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; [Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased susceptibility to Nicotine; [Atenolol co-treated with ADRB1] results in increased abundance of Cyclic AMP; Atenolol binds to and results in decreased activity of ADRB1 protein; Atenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [CGP 12177 results in increased activity of ADRB1 protein]; Atenolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Atenolol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]
ADRB1 protein polymorphism affects the susceptibility to Atenolol
Atenolol results in decreased expression of ADRB1 mRNA
CTD PMID:1389726 PMID:2462161 PMID:2897299 PMID:8102213 PMID:8386603 PMID:9593075 PMID:10372227 PMID:10894789 PMID:11425575 PMID:11483288 PMID:12022239 PMID:12761341 PMID:14730417 PMID:15060759 PMID:17003101 PMID:17369603 PMID:17628611 PMID:22192668 NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904
JBrowse link
G ADRB2 adrenoceptor beta 2 increases expression
affects binding
multiple interactions
EXP
ISO
Atenolol results in increased expression of ADRB2 protein
Atenolol binds to ADRB2 protein
Atenolol binds to and results in decreased activity of ADRB2 protein; Atenolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Atenolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]
[Atenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Atenolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; Atenolol binds to and results in decreased activity of ADRB2 protein; Atenolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]; Atenolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Atenolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; Atenolol inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; Atenolol inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]
CTD PMID:2462161 PMID:6093157 PMID:9593075 PMID:11425575 PMID:11483288 PMID:12920204 PMID:14730417 PMID:17925438 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,825,245...148,828,687
JBrowse link
G ADRB3 adrenoceptor beta 3 multiple interactions EXP Atenolol inhibits the reaction [cyanopindolol binds to ADRB3 protein] CTD PMID:14730417 NCBI chr 8:37,962,990...37,966,599
Ensembl chr 8:37,962,990...37,966,599
JBrowse link
G AGT angiotensinogen affects response to substance
decreases expression
EXP AGT gene SNP affects the susceptibility to Atenolol
Atenolol results in decreased expression of AGT protein
CTD PMID:14639093 PMID:14700505 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G AMY2B amylase alpha 2B multiple interactions ISO Atenolol inhibits the reaction [Apomorphine results in increased secretion of and results in increased activity of AMY1A protein]; Atenolol inhibits the reaction [Cisplatin results in increased secretion of and results in increased activity of AMY1A protein]; Atenolol inhibits the reaction [Isoproterenol results in increased secretion of and results in increased activity of AMY1A protein]; Atenolol inhibits the reaction [Lithium Chloride results in increased secretion of and results in increased activity of AMY1A protein] CTD PMID:21173550 NCBI chr 1:103,554,644...103,579,534
Ensembl chr 1:103,553,815...103,579,534
JBrowse link
G APOA1 apolipoprotein A1 decreases expression EXP Atenolol results in decreased expression of APOA1 protein CTD PMID:2193493 NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622
Ensembl chr11:116,835,751...116,837,622
JBrowse link
G APOA2 apolipoprotein A2 decreases expression EXP Atenolol results in decreased expression of APOA2 protein CTD PMID:2193493 NCBI chr 1:161,222,292...161,223,628
Ensembl chr 1:161,222,292...161,223,631
JBrowse link
G APOB apolipoprotein B increases expression EXP Atenolol results in increased expression of APOB; Atenolol results in increased expression of APOB protein CTD PMID:1928808 PMID:2193493 NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073
JBrowse link
G ATF1 activating transcription factor 1 multiple interactions EXP Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of ATF1 protein] CTD PMID:16671086 NCBI chr12:50,763,682...50,821,162
Ensembl chr12:50,763,710...50,821,162
JBrowse link
G B2M beta-2-microglobulin decreases expression EXP Atenolol results in decreased expression of B2M protein CTD PMID:2656332 NCBI chr15:44,711,492...44,718,145
Ensembl chr15:44,711,487...44,718,877
JBrowse link
G BDKRB2 bradykinin receptor B2 affects response to substance EXP BDKRB2 exon polymorphism affects the susceptibility to Atenolol CTD PMID:12640257 NCBI chr14:96,204,839...96,244,164
Ensembl chr14:96,204,679...96,244,166
JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C increases response to substance EXP CACNA1C gene polymorphism results in increased susceptibility to Atenolol CTD PMID:20031608 NCBI chr12:1,969,552...2,697,950
Ensembl chr12:1,970,786...2,697,950
JBrowse link
G CASP3 caspase 3 multiple interactions EXP Atenolol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein] CTD PMID:10728402 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CAT catalase multiple interactions ISO Atenolol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Atenolol promotes the reaction [Quercetin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]]; Atenolol promotes the reaction [Thyroxine results in decreased expression of CAT protein]; Quercetin promotes the reaction [Atenolol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]] CTD PMID:2575990 PMID:22391854 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CDK1 cyclin dependent kinase 1 multiple interactions ISO Atenolol inhibits the reaction [Isoproterenol results in increased expression of CDK1 mRNA] CTD PMID:9593584 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CLEC2B C-type lectin domain family 2 member B increases expression EXP Atenolol results in increased expression of CLEC2B mRNA CTD PMID:19915711 NCBI chr12:9,852,369...9,869,354
Ensembl chr12:9,852,984...9,870,136
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions EXP Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of CREB1 protein] CTD PMID:16671086 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G EDN1 endothelin 1 affects response to substance EXP EDN1 gene polymorphism affects the susceptibility to Atenolol CTD PMID:15188945 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions EXP Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of EGFR protein] CTD PMID:16671086 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G FAS Fas cell surface death receptor multiple interactions EXP Atenolol inhibits the reaction [Epinephrine results in increased expression of FAS protein] CTD PMID:10728402 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FASLG Fas ligand multiple interactions EXP Atenolol inhibits the reaction [Epinephrine results in increased expression of FASLG protein] CTD PMID:10728402 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FKBP1B FKBP prolyl isomerase 1B multiple interactions EXP Atenolol promotes the reaction [FKBP1B protein binds to RYR2 protein] CTD PMID:12743001 NCBI chr 2:24,033,205...24,067,743
Ensembl chr 2:24,049,701...24,063,681
JBrowse link
G FKBP5 FKBP prolyl isomerase 5 decreases expression EXP Atenolol results in decreased expression of FKBP5 mRNA CTD PMID:19915711 NCBI chr 6:35,573,590...35,728,583
Ensembl chr 6:35,573,585...35,728,583
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions ISO Atenolol inhibits the reaction [Dopamine results in increased activity of G6PD protein]; Atenolol inhibits the reaction [Isoproterenol results in increased activity of G6PD protein] CTD PMID:1978808 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GJA1 gap junction protein alpha 1 increases expression ISO Atenolol results in increased expression of GJA1 protein CTD PMID:16448880 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G GJA4 gap junction protein alpha 4 increases expression ISO Atenolol results in increased expression of GJA4 protein CTD PMID:16448880 NCBI chr 1:34,792,958...34,795,747
Ensembl chr 1:34,792,999...34,795,747
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 decreases expression ISO Atenolol results in decreased expression of GRK2 mRNA; Atenolol results in decreased expression of GRK2 protein CTD PMID:9788834 NCBI chr11:67,266,420...67,286,556
Ensembl chr11:67,266,473...67,286,556
JBrowse link
G INS insulin multiple interactions EXP Atenolol inhibits the reaction [Terbutaline results in increased expression of INS protein] CTD PMID:12795776 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,341
Ensembl chr11:2,159,779...2,161,341
JBrowse link
G KCNJ2 potassium inwardly rectifying channel subfamily J member 2 affects response to substance EXP KCNJ2 gene affects the susceptibility to Atenolol CTD PMID:15028050 NCBI chr17:70,169,532...70,180,044
Ensembl chr17:70,168,673...70,180,044
Ensembl chr17:70,168,673...70,180,044
JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 affects response to substance EXP KCNQ1 gene affects the susceptibility to Atenolol CTD PMID:15028050 NCBI chr11:2,445,008...2,849,110
Ensembl chr11:2,444,684...2,849,105
Ensembl chr11:2,444,684...2,849,105
JBrowse link
G LIPC lipase C, hepatic type multiple interactions EXP LIPC gene SNP affects the susceptibility to and affects the metabolism of Atenolol CTD PMID:23536766 NCBI chr15:58,410,457...58,569,844
Ensembl chr15:58,410,569...58,569,844
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK1 protein] CTD PMID:16671086 PMID:17003101 PMID:17925438 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK3 protein] CTD PMID:16671086 PMID:17003101 PMID:17925438 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Atenolol inhibits the reaction [carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [carvedilol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Atenolol inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Dopamine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:19439816 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NPPA natriuretic peptide A decreases expression EXP Atenolol results in decreased expression of NPPA protein CTD PMID:12866806 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G NPPB natriuretic peptide B multiple interactions
decreases expression
increases expression
ISO
EXP
[Atenolol co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Atenolol co-treated with Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA
Atenolol results in decreased expression of NPPB mRNA
Atenolol results in increased expression of NPPB protein
CTD PMID:15969258 PMID:18192850 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945
JBrowse link
G PLA2G4C phospholipase A2 group IVC multiple interactions EXP PLA2G4C gene SNP affects the susceptibility to and affects the metabolism of Atenolol CTD PMID:23536766 NCBI chr19:48,047,846...48,111,383
Ensembl chr19:48,047,843...48,110,817
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein] CTD PMID:17003101 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G PTPN5 protein tyrosine phosphatase non-receptor type 5 multiple interactions ISO Atenolol inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein] CTD PMID:17623046 NCBI chr11:18,727,928...18,792,721
Ensembl chr11:18,727,928...18,792,721
JBrowse link
G REN renin multiple interactions
decreases expression
decreases activity
EXP
ISO
[aliskiren co-treated with Atenolol] results in decreased activity of REN protein; [Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein
Atenolol results in decreased expression of REN protein
Atenolol inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of REN protein]; Atenolol inhibits the reaction [2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein]
Atenolol results in decreased activity of REN protein
CTD PMID:3142437 PMID:3333524 PMID:9300315 PMID:14639093 PMID:18957387 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324
JBrowse link
G RYR2 ryanodine receptor 2 increases activity
multiple interactions
EXP Atenolol results in increased activity of RYR2 protein
Atenolol promotes the reaction [FKBP1B protein binds to RYR2 protein]
CTD PMID:12743001 NCBI chr 1:237,042,184...237,833,988
Ensembl chr 1:237,042,184...237,833,988
JBrowse link
G SLC19A1 solute carrier family 19 member 1 decreases expression EXP Atenolol results in decreased expression of SLC19A1 mRNA CTD PMID:19616087 NCBI chr21:45,502,517...45,563,140
Ensembl chr21:45,493,572...45,573,365
JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions EXP Atenolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 6:160,121,808...160,160,590
Ensembl chr 6:160,121,815...160,158,718
JBrowse link
G SLC6A8 solute carrier family 6 member 8 decreases expression EXP Atenolol results in decreased expression of SLC6A8 mRNA CTD PMID:19915711 NCBI chr  X:153,687,926...153,696,593
Ensembl chr  X:153,687,926...153,696,588
JBrowse link
G SLCO4C1 solute carrier organic anion transporter family member 4C1 increases expression EXP Atenolol results in increased expression of SLCO4C1 mRNA CTD PMID:19915711 NCBI chr 5:102,233,986...102,296,516
Ensembl chr 5:102,233,986...102,296,284
JBrowse link
G SNORA49 small nucleolar RNA, H/ACA box 49 increases expression EXP Atenolol results in increased expression of SNORA49 mRNA CTD PMID:19915711 NCBI chr12:132,031,224...132,031,360
Ensembl chr12:132,031,224...132,031,359
JBrowse link
G SNRPN small nuclear ribonucleoprotein polypeptide N increases expression EXP Atenolol results in increased expression of SNRPN mRNA CTD PMID:19915711 NCBI chr15:24,823,637...24,978,723
Ensembl chr15:24,823,637...24,978,723
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP
ISO
Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]
Atenolol promotes the reaction [Thyroxine results in decreased expression of SOD1 protein]
CTD PMID:2575990 PMID:11163531 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions EXP
ISO
Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]
Atenolol inhibits the reaction [Thyroxine results in increased expression of SOD2 protein]
CTD PMID:2575990 PMID:11163531 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 decreases response to substance ISO TRPA1 gene mutant form results in decreased susceptibility to Atenolol CTD PMID:29627347 NCBI chr 8:72,021,250...72,094,885
Ensembl chr 8:72,019,917...72,075,584
JBrowse link
G TXN thioredoxin increases expression EXP Atenolol results in increased expression of TXN mRNA CTD PMID:19915711 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
JBrowse link
ATP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA8 ATP binding cassette subfamily A member 8 multiple interactions EXP Adenosine Triphosphate affects the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:12379217 NCBI chr17:68,867,285...68,955,415
Ensembl chr17:68,867,289...68,955,392
JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
increases hydrolysis
EXP
ISO
[Cobalt results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate; [Magnesium results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate; [Manganese results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate; ABCB1 protein binds to and results in increased hydrolysis of Adenosine Triphosphate; aurapten promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; crizotinib promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram affects the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; lapatinib promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; nobiletin promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]
[Rifampin metabolite results in decreased activity of ABCB1A protein] which results in decreased abundance of Adenosine Triphosphate
CTD PMID:2900677 PMID:14978246 PMID:18829547 PMID:18955043 PMID:22233293 PMID:23685082 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCB11 ATP binding cassette subfamily B member 11 multiple interactions EXP
ISO
Adenosine Triphosphate promotes the reaction [ABCB11 protein results in increased uptake of fexofenadine] CTD PMID:18245269 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 multiple interactions
affects activity
increases hydrolysis
affects binding
EXP
ISO
[Adenosine Triphosphate affects the activity of ABCC1 protein] which results in increased transport of Acetaminophen metabolite; ABCC1 protein binds to and results in increased degradation of Adenosine Triphosphate; ABCC1 protein binds to and results in increased hydrolysis of Adenosine Triphosphate; ABCC1 protein mutant form binds to and results in increased hydrolysis of Adenosine Triphosphate; Adenosine Triphosphate binds to and affects the folding of ABCC1 protein; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of estradiol-17 beta-glucuronide]; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Leukotriene C4]; daidzein promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; hesperetin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; naringenin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; nobiletin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Quercetin affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Resveratrol promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Silymarin inhibits the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
Daunorubicin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Vanadates inhibits the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
Adenosine Triphosphate binds to ABCC1 protein
CTD PMID:10856430 PMID:11278000 PMID:14978246 PMID:15245331 PMID:15355964 PMID:15459206 PMID:15737336 PMID:15838832 PMID:16156793 PMID:18336795 PMID:18955043 PMID:32472168 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 multiple interactions
affects activity
affects metabolic processing
ISO
EXP
Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased secretion of Fluo-3]; Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased transport of temocaprilat]
Adenosine Triphosphate affects the activity of ABCC2 protein
[Adenosine Triphosphate affects the activity of ABCC2 protein] which results in increased transport of Acetaminophen metabolite; [Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; Adenosine Triphosphate affects the reaction [ABCC2 protein results in increased transport of Mercury]; verlukast inhibits the reaction [[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide]
ABCC2 protein affects the metabolism of Adenosine Triphosphate
Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased transport of S-1,2-dichlorovinyl-N-acetylcysteine]
CTD PMID:9067317 PMID:9794919 PMID:20060011 PMID:22027652 PMID:24039982 PMID:32003934 PMID:32472168 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 multiple interactions ISO Adenosine Triphosphate promotes the reaction [ABCC3 protein affects the transport of fexofenadine] CTD PMID:18245269 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253
JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 multiple interactions
affects activity
increases hydrolysis
EXP [Adenosine Triphosphate affects the activity of ABCC4 protein] which results in increased transport of Acetaminophen metabolite; ABCC4 protein binds to and results in increased hydrolysis of Adenosine Triphosphate; daidzein promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram inhibits the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; hesperetin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; naringenin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Quercetin affects the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Quercetin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]]; Resveratrol promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Silymarin inhibits the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Silymarin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]] CTD PMID:14978246 PMID:16156793 PMID:32472168 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
JBrowse link
G ABCC6 ATP binding cassette subfamily C member 6 affects binding EXP Adenosine Triphosphate binds to ABCC6 protein CTD PMID:11880368 NCBI chr16:16,149,565...16,223,617
Ensembl chr16:16,148,928...16,223,522
JBrowse link
G ABCC8 ATP binding cassette subfamily C member 8 multiple interactions ISO Adenosine Triphosphate deficiency inhibits the reaction [Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]] CTD PMID:19095654 NCBI chr11:17,392,498...17,476,849
Ensembl chr11:17,392,498...17,476,879
JBrowse link
G ABCC9 ATP binding cassette subfamily C member 9 multiple interactions ISO Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]]
Adenosine Triphosphate results in decreased activity of [KCNJ8 protein binds to ABCC9 protein]
CTD PMID:11390963 PMID:28842488 NCBI chr12:21,797,389...21,941,863
Ensembl chr12:21,797,401...21,942,529
JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) increases hydrolysis
multiple interactions
EXP ABCG2 protein results in increased hydrolysis of Adenosine Triphosphate
[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate; Lapatinib promotes the reaction [ABCG2 protein results in increased hydrolysis of Adenosine Triphosphate]; Sulfasalazine inhibits the reaction [[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate]
CTD PMID:18829547 PMID:32003934 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628
JBrowse link
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions EXP [ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein; sorafenib inhibits the reaction [[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein] CTD PMID:19366808 NCBI chr 9:130,713,881...130,887,675
Ensembl chr 9:130,713,016...130,887,675
JBrowse link
G ADCYAP1 adenylate cyclase activating polypeptide 1 increases secretion ISO ADCYAP1 protein results in increased secretion of Adenosine Triphosphate CTD PMID:18563302 NCBI chr18:904,384...912,172
Ensembl chr18:904,871...912,172
JBrowse link
G AGTR1 angiotensin II receptor type 1 multiple interactions
decreases expression
ISO Adenosine Triphosphate results in decreased expression of and results in decreased activity of AGTR1A protein; ARRB2 protein affects the reaction [Adenosine Triphosphate results in decreased activity of AGTR1A protein]; CABIN1 protein inhibits the reaction [Adenosine Triphosphate results in decreased expression of and results in decreased activity of AGTR1A protein]; Cyclosporine inhibits the reaction [Adenosine Triphosphate results in decreased expression of AGTR1A mRNA]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Adenosine Triphosphate results in decreased expression of AGTR1A mRNA]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Adenosine Triphosphate results in decreased expression of AGTR1A protein] CTD PMID:21464294 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions ISO Adenosine Triphosphate affects the folding of [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:1848756 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases activity
multiple interactions
EXP Adenosine Triphosphate results in decreased activity of AKT1 protein
Alcohols inhibits the reaction [Adenosine Triphosphate results in decreased activity of AKT1 protein]
CTD PMID:24300283 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALDH5A1 aldehyde dehydrogenase 5 family member A1 increases abundance ISO ALDH5A1 gene mutant form results in increased abundance of Adenosine Triphosphate CTD PMID:29031482 NCBI chr 6:24,494,969...24,537,207
Ensembl chr 6:24,494,867...24,537,207
JBrowse link
G ALK ALK receptor tyrosine kinase affects binding
multiple interactions
EXP ALK protein binds to Adenosine Triphosphate
[ALK protein mutant form promotes the reaction [ALK protein binds to Adenosine Triphosphate]] which results in decreased susceptibility to crizotinib; ALK protein mutant form promotes the reaction [ALK protein binds to Adenosine Triphosphate]
CTD PMID:22072639 NCBI chr 2:29,190,992...29,921,589
Ensembl chr 2:29,192,774...29,921,586
JBrowse link
G ALPL alkaline phosphatase, biomineralization associated increases response to substance
multiple interactions
ISO ALPL gene mutant form results in increased susceptibility to Adenosine Triphosphate
ALPL gene mutant form promotes the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]
CTD PMID:27466191 NCBI chr 1:21,508,984...21,578,412
Ensembl chr 1:21,509,397...21,578,410
JBrowse link
G ANXA1 annexin A1 multiple interactions ISO [Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein; arsenite affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein]; Cadmium affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein]; chromium hexavalent ion affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein]; Lead affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein] CTD PMID:20655937 NCBI chr 9:73,151,865...73,170,393
Ensembl chr 9:73,151,865...73,170,393
JBrowse link
G APP amyloid beta precursor protein increases secretion
multiple interactions
EXP Adenosine Triphosphate results in increased secretion of APP protein modified form
Adenosine Triphosphate inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified form]; Adenosine Triphosphate inhibits the reaction [Rotenone results in decreased secretion of APP protein modified form]; Rotenone inhibits the reaction [Adenosine Triphosphate results in increased secretion of APP protein modified form]; Sodium Azide inhibits the reaction [Adenosine Triphosphate results in increased secretion of APP protein modified form]
CTD PMID:22906069 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G ARRB2 arrestin beta 2 multiple interactions ISO Adenosine Triphosphate promotes the reaction [RELA protein binds to ARRB2 protein]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to ARRB2 protein]]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]]; ARRB2 protein affects the reaction [Adenosine Triphosphate results in decreased activity of AGTR1A protein] CTD PMID:21464294 NCBI chr17:4,710,619...4,721,500
Ensembl chr17:4,710,596...4,721,499
JBrowse link
G ASIC1 acid sensing ion channel subunit 1 multiple interactions ISO [Acids binds to and affects the activity of ASIC1 protein] which results in increased secretion of Adenosine Triphosphate CTD PMID:19860742 NCBI chr12:50,057,596...50,083,622
Ensembl chr12:50,057,548...50,083,611
JBrowse link
G ASIC2 acid sensing ion channel subunit 2 multiple interactions ISO [Acids binds to and affects the activity of ASIC2 protein] which results in increased secretion of Adenosine Triphosphate CTD PMID:19860742 NCBI chr17:33,013,087...34,156,768
Ensembl chr17:33,013,087...34,174,964
JBrowse link
G ASIC3 acid sensing ion channel subunit 3 multiple interactions ISO [Acids binds to and affects the activity of ASIC3 protein] which results in increased secretion of Adenosine Triphosphate CTD PMID:19860742 NCBI chr 7:151,048,292...151,052,756
Ensembl chr 7:151,048,292...151,052,756
JBrowse link
G ATP7A ATPase copper transporting alpha multiple interactions EXP [Copper co-treated with Adenosine Triphosphate] results in increased phosphorylation of ATP7A protein CTD PMID:20964302 NCBI chr  X:77,910,693...78,050,395
Ensembl chr  X:77,910,656...78,050,395
JBrowse link
G ATP7B ATPase copper transporting beta multiple interactions
increases phosphorylation
EXP [Copper co-treated with Adenosine Triphosphate] results in increased phosphorylation of ATP7B protein
Adenosine Triphosphate results in increased phosphorylation of ATP7B protein
CTD PMID:19405516 PMID:20964302 NCBI chr13:51,932,669...52,012,130
Ensembl chr13:51,930,436...52,012,125
JBrowse link
G ATP8B1 ATPase phospholipid transporting 8B1 increases hydrolysis ISO ATP8B1 protein results in increased hydrolysis of Adenosine Triphosphate CTD PMID:11584374 NCBI chr18:57,646,426...57,803,822
Ensembl chr18:57,646,426...57,803,315
JBrowse link
G AVP arginine vasopressin multiple interactions
increases secretion
ISO Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of AVP protein]; bisindolylmaleimide I inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; Dactinomycin inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of AVP protein] CTD PMID:11102496 NCBI chr20:3,082,556...3,093,521
Ensembl chr20:3,082,556...3,084,724
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP [Adenosine Triphosphate binds to P2RY11 protein] which results in decreased expression of BCL2 protein CTD PMID:21503959 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCR BCR activator of RhoGEF and GTPase multiple interactions EXP [BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein; sorafenib inhibits the reaction [[BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein] CTD PMID:19366808 NCBI chr22:23,180,509...23,318,037
Ensembl chr22:23,179,704...23,318,037
JBrowse link
G CABIN1 calcineurin binding protein 1 multiple interactions ISO CABIN1 protein inhibits the reaction [Adenosine Triphosphate results in decreased expression of and results in decreased activity of AGTR1A protein] CTD PMID:21464294 NCBI chr22:24,011,192...24,178,628
Ensembl chr22:24,011,192...24,178,628
JBrowse link
G CALCA calcitonin related polypeptide alpha increases secretion
multiple interactions
ISO Adenosine Triphosphate results in increased secretion of CALCA protein
Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]]; Suramin inhibits the reaction [Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]]
CTD PMID:12044622 NCBI chr11:14,966,668...14,972,361
Ensembl chr11:14,966,668...14,972,354
JBrowse link
G CASP1 caspase 1 increases activity
multiple interactions
ISO
EXP
Adenosine Triphosphate results in increased activity of CASP1 mRNA; Adenosine Triphosphate results in increased activity of CASP1 protein
[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of CASP1 mRNA; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased secretion of and results in increased activity of CASP1 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein; fraxinellone inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein]; KN 62 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; Resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of CASP1 mRNA]; Resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased secretion of and results in increased activity of CASP1 protein]
[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [PML protein binds to CASP1 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein; Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP1 protein]; arsenic trioxide inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]
CTD PMID:18604214 PMID:19130485 PMID:21832250 PMID:23430110 PMID:24149798 PMID:25288807 PMID:25448682 PMID:26431797 PMID:26586371 NCBI chr11:105,025,443...105,035,591
Ensembl chr11:105,025,443...105,035,250
JBrowse link
G CASP3 caspase 3 increases expression
multiple interactions
EXP Adenosine Triphosphate results in increased expression of CASP3
Suramin inhibits the reaction [Adenosine Triphosphate results in increased expression of CASP3]
CTD PMID:19448140 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP4 caspase 4 multiple interactions EXP
ISO
[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of CASP4 mRNA; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased secretion of and results in increased activity of CASP4 protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of CASP4 mRNA]; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased secretion of and results in increased activity of CASP4 protein]
Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP4 protein]
CTD PMID:24149798 PMID:25288807 NCBI chr11:104,942,866...104,968,596
Ensembl chr11:104,942,866...104,969,366
JBrowse link
G CAT catalase increases expression EXP Adenosine Triphosphate results in increased expression of CAT mRNA CTD PMID:22129738 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL3 C-C motif chemokine ligand 3 increases secretion
multiple interactions
ISO Adenosine Triphosphate results in increased secretion of CCL3 protein
azetidine inhibits the reaction [Adenosine Triphosphate results in increased secretion of CCL3 protein]
CTD PMID:26522449 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169
JBrowse link
G CFTR CF transmembrane conductance regulator multiple interactions EXP 3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [Adenosine Triphosphate promotes the reaction [CFTR protein results in increased export of Chlorides]]; [Phosphatidylinositol 4,5-Diphosphate co-treated with Adenosine Triphosphate] results in increased activity of CFTR protein; Adenosine Triphosphate affects the reaction [Curcumin results in increased activity of CFTR protein mutant form]; Adenosine Triphosphate binds to and results in increased activity of CFTR protein; Adenosine Triphosphate promotes the reaction [CFTR protein results in increased export of Chlorides] CTD PMID:14710196 PMID:15623556 PMID:17178710 PMID:20675434 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G CHORDC1 cysteine and histidine rich domain containing 1 multiple interactions EXP
ISO
Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to PPP5C protein]; Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to SUGT1 protein]
Adenosine Triphosphate binds to and affects the folding of CHORDC1 protein; Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to CHORDC1 protein]; Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to HSP90AA1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to CHORDC1 protein]
CTD PMID:23184943 NCBI chr11:90,200,429...90,223,082
Ensembl chr11:90,200,429...90,223,077
JBrowse link
G COMT catechol-O-methyltransferase multiple interactions EXP [Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate CTD PMID:14975680 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,733...19,969,975
Ensembl chr22:19,941,733...19,969,975
JBrowse link
G CPT2 carnitine palmitoyltransferase 2 multiple interactions EXP [Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate; Carnitine promotes the reaction [[Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate] CTD PMID:21816645 NCBI chr 1:53,196,824...53,214,197
Ensembl chr 1:53,196,792...53,214,197
JBrowse link
G CRKL CRK like proto-oncogene, adaptor protein multiple interactions EXP [ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein; [BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein; sorafenib inhibits the reaction [[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein]; sorafenib inhibits the reaction [[BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein] CTD PMID:19366808 NCBI chr22:20,917,407...20,953,747
Ensembl chr22:20,917,407...20,953,747
JBrowse link
G CSNK2A1 casein kinase 2 alpha 1 multiple interactions
affects binding
EXP 5-(3-chlorophenylamino)benzo(c)(2,6)naphthyridine-8-carboxylic acid inhibits the reaction [Adenosine Triphosphate binds to [CSNK2A1 protein binds to CSNK2A1 protein binds to CSNK2B protein binds to CSNK2B protein]] CTD PMID:21174434 NCBI chr20:472,498...543,790
Ensembl chr20:472,498...543,835
JBrowse link
G CSNK2B casein kinase 2 beta multiple interactions
affects binding
EXP 5-(3-chlorophenylamino)benzo(c)(2,6)naphthyridine-8-carboxylic acid inhibits the reaction [Adenosine Triphosphate binds to [CSNK2A1 protein binds to CSNK2A1 protein binds to CSNK2B protein binds to CSNK2B protein]] CTD PMID:21174434 NCBI chr 6:31,666,080...31,670,067
Ensembl chr 6:31,665,236...31,670,343
Ensembl chr 6:31,665,236...31,670,343
JBrowse link
G CSTB cystatin B multiple interactions ISO Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP1 protein]; Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP4 protein] CTD PMID:25288807 NCBI chr21:43,773,950...43,776,308
Ensembl chr21:43,772,511...43,776,330
Ensembl chr21:43,772,511...43,776,330
Ensembl chr21:43,772,511...43,776,330
JBrowse link
G CTSB cathepsin B increases activity
multiple interactions
ISO Adenosine Triphosphate results in increased activity of CTSB protein
azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of CTSB protein]
CTD PMID:26522449 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,448
JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 increases secretion
multiple interactions
ISO Adenosine Triphosphate results in increased secretion of CXCL2 protein
azetidine inhibits the reaction [Adenosine Triphosphate results in increased secretion of CXCL2 protein]
CTD PMID:26522449 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
JBrowse link
G DMD dystrophin increases secretion
multiple interactions
ISO DMD gene mutant form results in increased secretion of Adenosine Triphosphate
Nifedipine inhibits the reaction [DMD gene mutant form results in increased secretion of Adenosine Triphosphate]
CTD PMID:24349043 NCBI chr  X:31,119,219...33,339,460
Ensembl chr  X:31,097,677...33,339,441
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions
increases phosphorylation
EXP sodium arsenite promotes the reaction [Adenosine Triphosphate results in increased phosphorylation of EGFR protein] CTD PMID:26104857 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EGR1 early growth response 1 multiple interactions
increases expression
ISO Iodoacetates inhibits the reaction [Adenosine Triphosphate results in increased expression of EGR1 mRNA]; Potassium Cyanide inhibits the reaction [Adenosine Triphosphate results in increased expression of EGR1 mRNA]; Sodium Azide inhibits the reaction [Adenosine Triphosphate results in increased expression of EGR1 mRNA] CTD PMID:10723097 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 multiple interactions EXP Adenosine Triphosphate promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein] CTD PMID:26072274 NCBI chr 8:119,557,085...119,673,404
Ensembl chr 8:119,557,086...119,673,453
JBrowse link
G ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 decreases activity EXP Adenosine Triphosphate results in decreased activity of ENPP7 protein CTD PMID:12885774 NCBI chr17:79,730,919...79,742,926
Ensembl chr17:79,730,943...79,742,219
JBrowse link
G ERCC6 ERCC excision repair 6, chromatin remodeling factor decreases abundance
multiple interactions
ISO ERCC6 gene mutant form results in decreased abundance of Adenosine Triphosphate
nicotinamide-beta-riboside inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Adenosine Triphosphate]
CTD PMID:25440059 NCBI chr10:49,434,881...49,539,538
Ensembl chr10:49,454,470...49,539,538
JBrowse link
G F2 coagulation factor II, thrombin multiple interactions
increases transport
increases abundance
increases secretion
EXP
ISO
calmidazolium affects the reaction [F2 protein results in increased secretion of Adenosine Triphosphate]; Fendiline affects the reaction [F2 protein results in increased secretion of Adenosine Triphosphate]; Quercetin inhibits the reaction [F2 protein results in increased abundance of Adenosine Triphosphate]; resveratrol inhibits the reaction [F2 protein results in increased abundance of Adenosine Triphosphate]
STXBP2 protein affects the reaction [F2 protein results in increased transport of Adenosine Triphosphate]
CTD PMID:2030746 PMID:15342215 PMID:30696774 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506
Ensembl chr11:46,719,196...46,739,506
JBrowse link
G FASN fatty acid synthase multiple interactions
decreases abundance
EXP FASN protein promotes the reaction [rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]]; Protein Kinase Inhibitors inhibits the reaction [FASN protein results in decreased abundance of Adenosine Triphosphate] CTD PMID:26670611 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Adenosine Triphosphate results in increased expression of FOS mRNA
ALPL gene mutant form promotes the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]
[Phenylephrine co-treated with Adenosine Triphosphate] results in increased expression of FOS mRNA; Glucose affects the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]; Iodoacetates inhibits the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]; Potassium Cyanide inhibits the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]; Sodium Azide inhibits the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]
CTD PMID:10723097 PMID:19463813 PMID:27466191 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FSCN1 fascin actin-bundling protein 1 multiple interactions
increases expression
EXP
ISO
Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of FSCN1 mRNA] CTD PMID:29733962 NCBI chr 7:5,592,816...5,606,655
Ensembl chr 7:5,592,816...5,606,655
JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP Adenosine Triphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog] CTD PMID:15788719 NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374
JBrowse link
G GH1 growth hormone 1 increases secretion
multiple interactions
EXP
ISO
Adenosine Triphosphate results in increased secretion of GH1 protein
NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]; oxophenylarsine inhibits the reaction [NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]]
oxophenylarsine inhibits the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]; Phosphatidylinositol 4,5-Diphosphate affects the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]
CTD PMID:12471042 NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839
JBrowse link
G GJA1 gap junction protein alpha 1 increases export EXP GJA1 protein mutant form results in increased export of Adenosine Triphosphate; GJA1 protein results in increased export of Adenosine Triphosphate CTD PMID:17687502 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions EXP [GSTP1 protein co-treated with Glutathione] inhibits the reaction [[Adenosine Triphosphate results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct]; [GSTP1 protein co-treated with Glutathione] inhibits the reaction [Adenosine Triphosphate results in increased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine] CTD PMID:11196146 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP Adenosine Triphosphate inhibits the reaction [protoporphyrin IX results in decreased activity of HIF1A protein] CTD PMID:23624237 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HMGB1 high mobility group box 1 affects chemical synthesis
multiple interactions
ISO HMGB1 protein affects the chemical synthesis of Adenosine Triphosphate
Adenosine Triphosphate promotes the reaction [fullerene C60 results in increased secretion of HMGB1 protein]; Adenosine Triphosphate promotes the reaction [graphene oxide results in increased secretion of HMGB1 protein]; Adenosine Triphosphate promotes the reaction [Nanotubes, Carbon results in increased secretion of HMGB1 protein]
CTD PMID:21641551 PMID:31504961 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to HSP90AA1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]; Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]] CTD PMID:23184943 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,738...102,139,699
Ensembl chr14:102,080,738...102,139,699
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 mRNA; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 mRNA]; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 protein] CTD PMID:24149798 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
JBrowse link
G HSPB1 heat shock protein family B (small) member 1 affects chemical synthesis ISO HSPB1 protein affects the chemical synthesis of Adenosine Triphosphate CTD PMID:21641551 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 multiple interactions
increases expression
ISO bisindolylmaleimide I inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]; chelerythrine inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]; Neomycin inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]; resveratrol inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]; tricyclodecane-9-yl-xanthogenate inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein] CTD PMID:16178011 NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP Adenosine Triphosphate inhibits the reaction [Fructose results in increased expression of ICAM1 protein] CTD PMID:18508964 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IFNG interferon gamma multiple interactions ISO Adenosine Triphosphate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone] CTD PMID:14623498 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL12B interleukin 12B multiple interactions EXP Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:17707769 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
JBrowse link
G IL18 interleukin 18 multiple interactions
increases secretion
EXP
ISO
[Adenosine Triphosphate co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL18 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein; Resveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA]; Resveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]
Adenosine Triphosphate results in increased secretion of IL18 protein
3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL18 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA; Acetylcysteine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]; diphenyleneiodonium inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]
CTD PMID:17404311 PMID:24149798 PMID:26431797 PMID:27311643 NCBI chr11:112,143,251...112,164,104
Ensembl chr11:112,143,253...112,164,096
JBrowse link
G IL1A interleukin 1 alpha multiple interactions ISO (N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1A protein]; (N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1A protein; Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein] CTD PMID:26068648 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1B interleukin 1 beta multiple interactions
increases secretion
decreases abundance
ISO
EXP
Enzyme Inhibitors inhibits the reaction [IL1B protein results in decreased abundance of Adenosine Triphosphate]; IL1B protein inhibits the reaction [Adenosine Triphosphate results in increased secretion of INS1 protein]; Quercetin inhibits the reaction [IL1B protein inhibits the reaction [Adenosine Triphosphate results in increased secretion of INS1 protein]]
Adenosine Triphosphate results in increased secretion of IL1B protein
(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; (N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL1B protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased activity of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein; Acetylcysteine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL1B protein]; Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Adenosine Triphosphate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]; Adenosine Triphosphate promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Adenosine Triphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Arsenic Trioxide inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; diphenyleneiodonium inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL1B protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]; Okadaic Acid inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; PML protein promotes the reaction [[resiquimod co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]; zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]]
[Adenosine Triphosphate co-treated with K-12 lipopolysaccharide] results in increased secretion of IL1B protein modified form; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein; [Tetradecanoylphorbol Acetate co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein; Adenosine Triphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein; Apigenin inhibits the reaction [Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein]; flavone analog inhibits the reaction [Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein]; KN 62 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein]; MitoTEMPO inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA]; Resveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone analog inhibits the reaction [Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein]
CTD PMID:10365824 PMID:14623498 PMID:17404311 PMID:18604214 PMID:19130485 PMID:22221676 PMID:23430110 PMID:24149798 PMID:24158569 PMID:24685903 PMID:26068648 PMID:26086368 PMID:26431797 PMID:26586371 PMID:26968431 PMID:27311643 PMID:29960001 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions
increases expression
EXP
ISO
Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; NF157 compound inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]; sodium arsenite promotes the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]; Suramin inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]
Adenosine Triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]; coomassie Brilliant Blue inhibits the reaction [Adenosine Triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]]; resveratrol inhibits the reaction [Adenosine Triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]]; SB 203580 inhibits the reaction [Adenosine Triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]]
azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]; MRS 2211 inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]
CTD PMID:17707769 PMID:24793913 PMID:24849676 PMID:25348860 PMID:26104857 PMID:26522449 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INS insulin multiple interactions EXP [ammonium ferrous sulfate results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate; [chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate; INS protein inhibits the reaction [Acetaminophen results in decreased abundance of Adenosine Triphosphate]; Mannose inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate]; Phloretin inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate] CTD PMID:17965850 PMID:26739624 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,341
Ensembl chr11:2,159,779...2,161,341
JBrowse link
G ITGB1BP2 integrin subunit beta 1 binding protein 2 multiple interactions EXP
ISO
Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to PPP5C protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]; Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]]
Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to CHORDC1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to ITGB1BP2 protein]; Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]]
CTD PMID:23184943 NCBI chr  X:71,301,750...71,305,371
Ensembl chr  X:71,301,750...71,305,371
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of JUN protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of JUN protein] CTD PMID:24149798 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity EXP Adenosine Triphosphate deficiency results in decreased activity of KCNH2 protein CTD PMID:12531891 NCBI chr 7:150,944,956...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 multiple interactions
decreases response to substance
ISO Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]]
KCNJ11 protein mutant form results in decreased susceptibility to Adenosine Triphosphate
CTD PMID:11390963 PMID:28842488 NCBI chr11:17,385,246...17,389,346
Ensembl chr11:17,385,859...17,389,331
JBrowse link
G KCNJ15 potassium inwardly rectifying channel subfamily J member 15 increases activity EXP Adenosine Triphosphate results in increased activity of KCNJ15 protein CTD PMID:15328350 NCBI chr21:38,229,926...38,307,357
Ensembl chr21:38,155,549...38,307,357
JBrowse link
G KCNJ8 potassium inwardly rectifying channel subfamily J member 8 multiple interactions
decreases response to substance
ISO Adenosine Triphosphate results in decreased activity of [KCNJ8 protein binds to ABCC9 protein]
KCNJ8 protein mutant form results in decreased susceptibility to Adenosine Triphosphate
CTD PMID:28842488 NCBI chr12:21,764,955...21,775,593
Ensembl chr12:21,764,955...21,775,600
JBrowse link
G KHK ketohexokinase multiple interactions EXP KHK protein promotes the reaction [Fructose results in decreased abundance of Adenosine Triphosphate] CTD PMID:19158351 NCBI chr 2:27,086,760...27,100,762
Ensembl chr 2:27,086,747...27,100,762
JBrowse link
G KIF5A kinesin family member 5A multiple interactions
increases hydrolysis
EXP Adenosine Triphosphate inhibits the reaction [zinc chloride results in decreased activity of KIF5A protein]; Cadmium Chloride inhibits the reaction [KIF5A protein results in increased hydrolysis of Adenosine Triphosphate]; Egtazic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [KIF5A protein results in increased hydrolysis of Adenosine Triphosphate]] CTD PMID:24239783 PMID:28122263 NCBI chr12:57,550,039...57,586,633
Ensembl chr12:57,546,026...57,586,633
Ensembl chr12:57,546,026...57,586,633
JBrowse link
G LEP leptin multiple interactions ISO [[Glucose co-treated with INS1 protein] results in increased abundance of Adenosine Triphosphate] which results in increased secretion of LEP protein; [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein CTD PMID:10780946 NCBI chr 7:128,241,201...128,257,629
Ensembl chr 7:128,241,278...128,257,629
JBrowse link
G LIPE lipase E, hormone sensitive type increases activity EXP Adenosine Triphosphate results in increased activity of LIPE protein CTD PMID:7155675 NCBI chr19:42,401,512...42,427,421
Ensembl chr19:42,401,514...42,427,388
JBrowse link
G LPL lipoprotein lipase affects response to substance EXP LPL protein affects the susceptibility to Adenosine Triphosphate CTD PMID:11786490 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259
JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 affects binding ISO Adenosine Triphosphate binds to MAP2K1 protein CTD PMID:17693661 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,817...66,492,312
Ensembl chr15:66,386,817...66,492,312
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
increases activity
EXP
ISO
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein]; [Alcohols co-treated with Adenosine Triphosphate] results in increased activity of MAPK1 protein; Alcohols inhibits the reaction [Adenosine Triphosphate results in increased activity of MAPK1 protein]; sodium arsenite promotes the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein]
azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein]
CTD PMID:12513686 PMID:15034929 PMID:21503959 PMID:24300283 PMID:26104857 PMID:26522449 PMID:30502331 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
increases activity
EXP
ISO
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein]; [Alcohols co-treated with Adenosine Triphosphate] results in increased activity of MAPK3 protein; Alcohols inhibits the reaction [Adenosine Triphosphate results in increased activity of MAPK3 protein]; sodium arsenite promotes the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein]
azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein]
CTD PMID:12513686 PMID:15034929 PMID:21503959 PMID:24300283 PMID:26104857 PMID:26522449 PMID:30502331 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPT microtubule associated protein tau multiple interactions ISO [annonacin results in decreased abundance of Adenosine Triphosphate] which affects the localization of MAPT protein CTD PMID:17634376 NCBI chr17:45,894,538...46,028,334
Ensembl chr17:45,894,551...46,028,334
Ensembl chr17:45,894,551...46,028,334
JBrowse link
G METRNL meteorin like, glial cell differentiation regulator multiple interactions ISO METRNL protein inhibits the reaction [Dietary Fats results in decreased abundance of Adenosine Triphosphate] CTD PMID:30213948 NCBI chr17:83,079,609...83,095,122
Ensembl chr17:83,079,609...83,095,122
JBrowse link
G MFN2 mitofusin 2 decreases response to substance
multiple interactions
increases chemical synthesis
ISO
EXP
MFN2 results in decreased susceptibility to Adenosine Triphosphate deficiency
MFN2 protein inhibits the reaction [TNF protein results in decreased chemical synthesis of Adenosine Triphosphate]
MFN2 protein results in increased chemical synthesis of Adenosine Triphosphate
MFN2 protein inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased chemical synthesis of Adenosine Triphosphate]
CTD PMID:22292091 PMID:24898700 PMID:25416777 NCBI chr 1:11,980,215...12,013,508
Ensembl chr 1:11,980,181...12,015,211
Ensembl chr 1:11,980,181...12,015,211
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
increases activity
increases secretion
ISO 1,10-phenanthroline inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]; SB 3CT compound inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]; wortmannin inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]
azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of MMP9 protein]
Adenosine Triphosphate results in increased secretion of MMP9 protein
CTD PMID:20195827 PMID:26522449 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MT-ATP6 mitochondrially encoded ATP synthase membrane subunit 6 affects abundance ISO ATP6 protein affects the abundance of Adenosine Triphosphate CTD PMID:18273840 NCBI chr MT:8,527...9,207
Ensembl chr MT:8,527...9,207
JBrowse link
G MT-CO3 mitochondrially encoded cytochrome c oxidase III increases abundance EXP COX3 protein results in increased abundance of Adenosine Triphosphate CTD PMID:17428446 NCBI chr MT:9,207...9,990
Ensembl chr MT:9,207...9,990
JBrowse link
G MVD mevalonate diphosphate decarboxylase increases hydrolysis EXP MVD protein results in increased hydrolysis of Adenosine Triphosphate CTD PMID:9392419 NCBI chr16:88,651,935...88,663,153
Ensembl chr16:88,651,935...88,663,161
JBrowse link
G MVK mevalonate kinase increases hydrolysis
multiple interactions
EXP MVK protein results in increased hydrolysis of Adenosine Triphosphate
3,3-dimethylallyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; dolichol monophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; Farnesol inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; farnesyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; geranyl diphosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; geranylgeranyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; isopentenyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]
CTD PMID:9392419 NCBI chr12:109,573,461...109,598,125
Ensembl chr12:109,573,255...109,598,125
JBrowse link
G MYH7 myosin heavy chain 7 increases abundance EXP MYH7 gene mutant form results in increased abundance of Adenosine Triphosphate CTD PMID:29741611 NCBI chr14:23,412,740...23,435,677
Ensembl chr14:23,412,740...23,435,660
JBrowse link
G NADSYN1 NAD synthetase 1 multiple interactions EXP [Ammonium Chloride co-treated with nicotinic acid adenine dinucleotide co-treated with Adenosine Triphosphate] results in increased activity of NADSYN1 protein; [NADSYN1 protein co-treated with Ammonium Chloride co-treated with nicotinic acid adenine dinucleotide co-treated with Adenosine Triphosphate] results in increased chemical synthesis of NAD CTD PMID:12547821 NCBI chr11:71,453,203...71,501,816
Ensembl chr11:71,453,109...71,524,107
JBrowse link
G NCS1 neuronal calcium sensor 1 multiple interactions
increases response to substance
ISO NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]; oxophenylarsine inhibits the reaction [NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]]
NCS1 protein results in increased susceptibility to Adenosine Triphosphate
CTD PMID:12471042 NCBI chr 9:130,172,404...130,237,303
Ensembl chr 9:130,172,404...130,237,303
JBrowse link
G NFATC1 nuclear factor of activated T cells 1 affects localization
multiple interactions
ISO Adenosine Triphosphate affects the localization of NFATC1 protein
azetidine analog inhibits the reaction [Adenosine Triphosphate affects the localization of NFATC1 protein]
CTD PMID:21464294 PMID:26522449 NCBI chr18:79,395,930...79,529,323
Ensembl chr18:79,395,856...79,529,325
JBrowse link
G NFATC3 nuclear factor of activated T cells 3 affects localization ISO Adenosine Triphosphate affects the localization of NFATC3 protein CTD PMID:21464294 NCBI chr16:68,085,370...68,229,259
Ensembl chr16:68,084,751...68,229,259
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO
EXP
Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]]
[Adenosine Triphosphate co-treated with Lipopolysaccharides] affects the localization of NFKBIA protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] affects the localization of NFKBIA protein]
CTD PMID:21464294 PMID:24149798 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NGF nerve growth factor multiple interactions ISO [NGF protein co-treated with Adenosine Triphosphate] results in increased uptake of Calcium CTD PMID:1374475 NCBI chr 1:115,285,915...115,338,253
Ensembl chr 1:115,285,917...115,338,256
Ensembl chr 1:115,285,917...115,338,256
Ensembl chr 1:115,285,917...115,338,256
JBrowse link
G NLRP1 NLR family pyrin domain containing 1 multiple interactions EXP [Lipopolysaccharides co-treated with Adenosine Triphosphate co-treated with resveratrol] results in increased expression of NLRP1 mRNA CTD PMID:24149798 NCBI chr17:5,501,396...5,584,509
Ensembl chr17:5,499,427...5,619,424
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions EXP
ISO
[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased activity of NLRP3 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate co-treated with resveratrol] results in increased expression of NLRP3 mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein; KN 62 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]
[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PML protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]]
CTD PMID:18604214 PMID:23430110 PMID:24149798 PMID:26086368 PMID:26586371 NCBI chr 1:247,416,163...247,448,823
Ensembl chr 1:247,416,156...247,449,108
JBrowse link
G NOLC1 nucleolar and coiled-body phosphoprotein 1 multiple interactions EXP Adenosine Triphosphate affects the reaction [Doxorubicin binds to NOLC1 protein] CTD PMID:17129415 NCBI chr10:102,152,370...102,163,870
Ensembl chr10:102,152,176...102,163,871
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
increases expression
EXP
ISO
NOS2 protein affects the reaction [Adenosine Triphosphate results in increased metabolism of RELA protein]
azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of NOS2 protein]
[Adenosine Triphosphate results in increased expression of NOS2 protein] promotes the reaction [NOS2 protein binds to RELA protein]; Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]]; Cyclosporine inhibits the reaction [[Adenosine Triphosphate results in increased expression of NOS2 protein] promotes the reaction [NOS2 protein binds to RELA protein]]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Adenosine Triphosphate results in increased expression of NOS2 protein]; NOS2 protein affects the reaction [Adenosine Triphosphate results in increased abundance of Nitric Oxide]
CTD PMID:21464294 PMID:26522449 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions EXP Adenosine Triphosphate affects the reaction [Alcohols affects the phosphorylation of NOS3 protein]; Adenosine Triphosphate inhibits the reaction [Alcohols results in decreased expression of NOS3 protein] CTD PMID:24300283 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G NPY neuropeptide Y affects response to substance EXP NPY protein affects the susceptibility to Adenosine Triphosphate CTD PMID:15003356 NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862
JBrowse link
G NR4A1 nuclear receptor subfamily 4 group A member 1 increases expression ISO Adenosine Triphosphate results in increased expression of NR4A1 mRNA CTD PMID:10723097 NCBI chr12:52,022,832...52,059,507
Ensembl chr12:52,022,832...52,059,507
JBrowse link
G OAS1 2'-5'-oligoadenylate synthetase 1 multiple interactions EXP [OAS1 protein results in increased metabolism of Adenosine Triphosphate] which results in increased chemical synthesis of 2',5'-oligoadenylate CTD PMID:15732009 NCBI chr12:112,906,956...112,933,219
Ensembl chr12:112,906,783...112,933,222
JBrowse link
G OXT oxytocin/neurophysin I prepropeptide multiple interactions
increases secretion
ISO Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of OXT protein] CTD PMID:11102496 NCBI chr20:3,068,871...3,072,517
Ensembl chr20:3,071,620...3,072,517
JBrowse link
G P2RX1 purinergic receptor P2X 1 multiple interactions ISO geldanamycin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1]; herbimycin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1]; monorden promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1] CTD PMID:11930156 NCBI chr17:3,896,591...3,916,506
Ensembl chr17:3,896,592...3,916,476
JBrowse link
G P2RX2 purinergic receptor P2X 2 multiple interactions
increases activity
affects response to substance
ISO 1-amino-4-(3-(4,6-dichloro(1,3,5)triazine-2-ylamino)phenylamino)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; Acetylcysteine inhibits the reaction [Rotenone promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; Cadmium Chloride affects the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; cobaltous chloride affects the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Copper promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; cupric chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Mercuric Chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Mercury promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; methyl methanethiosulfonate inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; methyl methanethiosulfonate inhibits the reaction [Mercury promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; myxothiazol promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; nickel chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; palladium chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Rotenone promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; zinc chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Zinc promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]
P2RX2 protein affects the susceptibility to Adenosine Triphosphate
CTD PMID:15081800 PMID:16190872 PMID:19793987 PMID:21207957 NCBI chr12:132,618,776...132,623,736
Ensembl chr12:132,618,776...132,622,388
JBrowse link
G P2RX3 purinergic receptor P2X 3 multiple interactions
affects activity
ISO Eugenol inhibits the reaction [P2RX3 protein affects the activity of Adenosine Triphosphate] CTD PMID:19967073 NCBI chr11:57,335,943...57,372,399
Ensembl chr11:57,338,352...57,372,396
JBrowse link
G P2RX4 purinergic receptor P2X 4 multiple interactions
increases activity
ISO
EXP
[Cadmium co-treated with Zinc] promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; [Mercury co-treated with Copper] inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Cadmium promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Cobalt promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Copper inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Copper inhibits the reaction [Zinc promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]]; Mercury inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Zinc promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]
5-(3-bromophenyl)-1,3-dihydro-2H-benzofuro(3,2-e)-1,4-diazepin-2-one inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; [ginsenoside M1 co-treated with Adenosine Triphosphate] results in increased activity of P2RX4 protein; [Resveratrol co-treated with Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX4 mRNA; [Resveratrol co-treated with Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX4 protein; ginsenoside M1 promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; ginsenoside Rb1 promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; ginsenoside Rd promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Ivermectin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]
CTD PMID:10737610 PMID:15629187 PMID:19793987 PMID:21638035 PMID:24149798 PMID:30545933 NCBI chr12:121,210,096...121,234,106
Ensembl chr12:121,209,861...121,234,106
Ensembl chr12:121,209,861...121,234,106
JBrowse link
G P2RX7 purinergic receptor P2X 7 multiple interactions
increases expression
decreases response to substance
increases response to substance
increases activity
EXP
ISO
[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 mRNA; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 protein; AZ10606120 inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]; P2RX7 protein affects the reaction [Adenosine Triphosphate results in increased secretion of SELL protein]; P2RX7 protein affects the reaction [Adenosine Triphosphate results in increased transport of Barium]; Resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 mRNA]; Resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 protein]
Adenosine Triphosphate results in increased expression of P2RX7 protein
P2RX7 gene mutant form results in decreased susceptibility to Adenosine Triphosphate
P2RX7 protein results in increased susceptibility to Adenosine Triphosphate
3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]; azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of P2RX7 protein]; coomassie Brilliant Blue inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]
CTD PMID:11003599 PMID:17728465 PMID:19023039 PMID:21638035 PMID:23565201 PMID:24101734 PMID:24149798 PMID:26522449 PMID:27466191 PMID:30545933 PMID:31504961 NCBI chr12:121,132,819...121,188,032
Ensembl chr12:121,132,819...121,188,032
JBrowse link
G P2RY1 purinergic receptor P2Y1 multiple interactions
affects activity
EXP
ISO
[Adenosine Triphosphate binds to and results in increased activity of P2RY1 protein] which results in increased abundance of Calcium; Adenosine Triphosphate binds to and results in increased activity of P2RY1 protein; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [P2RY1 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]]; P2RY1 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]; Trichloroethylene inhibits the reaction [[Adenosine Triphosphate binds to and results in increased activity of P2RY1 protein] which results in increased abundance of Calcium]
[N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate binds to and results in decreased activity of P2RY1 protein] inhibits the reaction [Adenosine Triphosphate results in increased uptake of Calcium]
Adenosine Triphosphate affects the activity of P2RY1 protein
CTD PMID:12694404 PMID:15243297 PMID:16973929 PMID:22129738 NCBI chr 3:152,835,131...152,841,439
Ensembl chr 3:152,835,131...152,841,439
JBrowse link
G P2RY11 purinergic receptor P2Y11 affects binding
multiple interactions
EXP Adenosine Triphosphate binds to P2RY11 protein
[Adenosine Triphosphate binds to P2RY11 protein] which results in decreased expression of BCL2 protein; [Adenosine Triphosphate binds to P2RY11 protein] which results in increased susceptibility to Cisplatin
CTD PMID:21503959 NCBI chr19:10,111,693...10,115,372
Ensembl chr19:10,111,693...10,115,372
JBrowse link
G P2RY13 purinergic receptor P2Y13 multiple interactions EXP MRS 2211 inhibits the reaction [P2RY13 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]]; P2RY13 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide] CTD PMID:22129738 NCBI chr 3:151,326,312...151,329,549
Ensembl chr 3:151,326,312...151,329,549
JBrowse link
G P2RY2 purinergic receptor P2Y2 multiple interactions
affects activity
increases activity
EXP
ISO
[Adenosine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Calcium
[Adenosine Triphosphate results in increased activity of P2RY2 protein] which results in increased uptake of Calcium
Adenosine Triphosphate affects the activity of P2RY2 protein
CTD PMID:11527950 PMID:15243297 PMID:17003265 NCBI chr11:73,200,416...73,246,743
Ensembl chr11:73,218,281...73,242,427
Ensembl chr11:73,218,281...73,242,427
JBrowse link
G P2RY4 pyrimidinergic receptor P2Y4 multiple interactions EXP [Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium; Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein; Trichloroethylene inhibits the reaction [[Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium] CTD PMID:12694404 NCBI chr  X:70,258,166...70,260,204
Ensembl chr  X:70,258,170...70,259,764
JBrowse link
G P2RY6 pyrimidinergic receptor P2Y6 multiple interactions EXP N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea inhibits the reaction [P2RY6 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]]; P2RY6 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide] CTD PMID:22129738 NCBI chr11:73,264,503...73,298,625
Ensembl chr11:73,264,505...73,298,625
Ensembl chr11:73,264,505...73,298,625
JBrowse link
G PANX1 pannexin 1 decreases activity
multiple interactions
increases export
EXP
ISO
Adenosine Triphosphate results in decreased activity of PANX1 protein
Carbenoxolone inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate]; Probenecid inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate]
CTD PMID:19023039 PMID:19213873 NCBI chr11:94,128,841...94,185,596
Ensembl chr11:94,128,841...94,181,968
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases expression
EXP
ISO
PARP1 mutant form inhibits the reaction [Cadmium results in decreased abundance of Adenosine Triphosphate]
PARP1 protein affects the reaction [pyrithione zinc results in decreased abundance of Adenosine Triphosphate]; PARP1 protein affects the reaction [Zinc results in decreased abundance of Adenosine Triphosphate]
Adenosine Triphosphate results in increased expression of PARP1 protein
CTD PMID:17728843 PMID:19809895 PMID:21767558 PMID:22253048 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PDK1 pyruvate dehydrogenase kinase 1 affects response to substance
multiple interactions
ISO PDK1 protein affects the susceptibility to Adenosine Triphosphate
[PDK1 protein affects the susceptibility to Adenosine Triphosphate] which affects the abundance of Calcium; Adenosine Triphosphate promotes the reaction [PDK1 protein affects the abundance of Calcium]; tubacin affects the reaction [[PDK1 protein affects the susceptibility to Adenosine Triphosphate] which affects the abundance of Calcium]
CTD PMID:28887310 NCBI chr 2:172,555,373...172,672,698
Ensembl chr 2:172,555,373...172,608,669
JBrowse link
G PFKM phosphofructokinase, muscle multiple interactions EXP Adenosine Triphosphate promotes the reaction [resveratrol results in decreased activity of PFKM protein] CTD PMID:23454376 NCBI chr12:48,105,353...48,146,404
Ensembl chr12:48,105,139...48,146,404
JBrowse link
G PGP phosphoglycolate phosphatase decreases phosphorylation ISO PGP protein results in decreased phosphorylation of Adenosine Triphosphate CTD PMID:24338473 NCBI chr16:2,211,593...2,214,840
Ensembl chr16:2,211,593...2,214,840
JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha multiple interactions
affects binding
EXP 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine inhibits the reaction [Adenosine Triphosphate binds to PIK3CA protein]; Adenosine Triphosphate inhibits the reaction [resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]] CTD PMID:17550345 PMID:18754654 NCBI chr 3:179,148,114...179,240,093
Ensembl chr 3:179,148,114...179,240,093
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP Adenosine Triphosphate inhibits the reaction [resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]] CTD PMID:17550345 NCBI chr 5:68,215,737...68,301,821
Ensembl chr 5:68,215,756...68,301,821
JBrowse link
G PLA2G4A phospholipase A2 group IVA increases activity ISO Adenosine Triphosphate results in increased activity of PLA2G4A protein CTD PMID:10535451 NCBI chr 1:186,828,949...186,988,981
Ensembl chr 1:186,828,949...186,988,981
JBrowse link
G PLAU plasminogen activator, urokinase increases secretion ISO Adenosine Triphosphate results in increased secretion of PLAU protein CTD PMID:20177776 NCBI chr10:73,909,182...73,917,497
Ensembl chr10:73,909,177...73,917,496
JBrowse link
G PLPP3 phospholipid phosphatase 3 decreases chemical synthesis ISO PLPP3 gene mutant form results in decreased chemical synthesis of Adenosine Triphosphate CTD PMID:28982073 NCBI chr 1:56,494,761...56,579,563
Ensembl chr 1:56,494,761...56,645,301
JBrowse link
G PML PML nuclear body scaffold multiple interactions ISO [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PML protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [PML protein binds to CASP1 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of PML protein; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased abundance of Reactive Oxygen Species]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; PML protein promotes the reaction [[resiquimod co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein] CTD PMID:23430110 NCBI chr15:73,994,716...74,047,827
Ensembl chr15:73,994,673...74,047,827
JBrowse link
G PMVK phosphomevalonate kinase increases hydrolysis EXP PMVK protein results in increased hydrolysis of Adenosine Triphosphate CTD PMID:9392419 NCBI chr 1:154,924,740...154,942,658
Ensembl chr 1:154,924,740...154,936,719
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO [Fenofibrate results in increased activity of PPARA protein] which results in decreased abundance of Adenosine Triphosphate CTD PMID:19593819 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
decreases abundance
EXP FASN protein promotes the reaction [rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]]; rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]; UCP1 protein promotes the reaction [PPARG protein mutant form results in decreased abundance of Adenosine Triphosphate]; UCP1 protein promotes the reaction [rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]]
PPARG protein mutant form results in decreased abundance of Adenosine Triphosphate; PPARG protein results in decreased abundance of Adenosine Triphosphate
CTD PMID:26670611 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPP5C protein phosphatase 5 catalytic subunit multiple interactions EXP Adenosine Triphosphate binds to and affects the folding of PPP5C protein; Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to PPP5C protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to PPP5C protein] CTD PMID:23184943 NCBI chr19:46,347,069...46,390,975
Ensembl chr19:46,347,087...46,392,981
JBrowse link
G PRDX2 peroxiredoxin 2 increases expression ISO Adenosine Triphosphate results in increased expression of PRDX2 protein modified form CTD PMID:16178011 NCBI chr19:12,796,823...12,801,800
Ensembl chr19:12,796,820...12,801,800
JBrowse link
G PRKCA protein kinase C alpha multiple interactions EXP [[Adenosine Triphosphate co-treated with PRKCA protein] results in increased phosphorylation of RALBP1 protein] which results in increased transport of Doxorubicin CTD PMID:16087181 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of PTGS2 protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of PTGS2 protein] CTD PMID:24149798 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G PYCARD PYD and CARD domain containing multiple interactions EXP
ISO
[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in decreased expression of PYCARD mRNA; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in decreased expression of PYCARD mRNA]
[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]]; PYCARD gene mutant form inhibits the reaction [Adenosine Triphosphate results in increased abundance of G(M3) Ganglioside]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]
CTD PMID:18604214 PMID:23430110 PMID:24149798 PMID:24475307 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450
JBrowse link
G RALBP1 ralA binding protein 1 multiple interactions EXP [[Adenosine Triphosphate co-treated with PRKCA protein] results in increased phosphorylation of RALBP1 protein] which results in increased transport of Doxorubicin; Adenosine Triphosphate promotes the reaction [RALBP1 protein affects the transport of Leukotriene C4] CTD PMID:15386349 PMID:16087181 NCBI chr18:9,475,513...9,538,114
Ensembl chr18:9,475,009...9,538,114
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
[Adenosine Triphosphate results in increased expression of NOS2 protein] promotes the reaction [NOS2 protein binds to RELA protein]; Adenosine Triphosphate promotes the reaction [RELA protein binds to ARRB2 protein]; Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]; Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to ARRB2 protein]]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]]; Cyclosporine inhibits the reaction [[Adenosine Triphosphate results in increased expression of NOS2 protein] promotes the reaction [NOS2 protein binds to RELA protein]]
[Adenosine Triphosphate co-treated with Lipopolysaccharides] affects the localization of RELA protein; NOS2 protein affects the reaction [Adenosine Triphosphate results in increased metabolism of RELA protein]; resveratrol promotes the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] affects the localization of RELA protein]; S-Nitrosoglutathione promotes the reaction [Adenosine Triphosphate results in increased metabolism of RELA protein]
CTD PMID:21464294 PMID:24149798 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RHOF ras homolog family member F, filopodia associated increases expression
multiple interactions
EXP
ISO
Adenosine Triphosphate results in increased expression of RHOF mRNA
Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of RHOF mRNA]
CTD PMID:29733962 NCBI chr12:121,777,754...121,793,688
Ensembl chr12:121,777,754...121,803,403
JBrowse link
G S100A10 S100 calcium binding protein A10 increases expression EXP Adenosine Triphosphate results in increased expression of S100A10 mRNA CTD PMID:29733962 NCBI chr 1:151,982,915...151,993,859
Ensembl chr 1:151,982,915...151,993,859
JBrowse link
G S100A11 S100 calcium binding protein A11 increases expression EXP Adenosine Triphosphate results in increased expression of S100A11 mRNA CTD PMID:29733962 NCBI chr 1:152,032,506...152,037,004
Ensembl chr 1:152,032,506...152,047,907
JBrowse link
G S100A4 S100 calcium binding protein A4 increases expression
multiple interactions
ISO
EXP
Adenosine Triphosphate results in increased expression of S100A4 mRNA
Adenosine Triphosphate results in increased expression of and results in increased secretion of S100A4 protein; Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of S100A4 protein]
CTD PMID:29733962 NCBI chr 1:153,543,621...153,545,806
Ensembl chr 1:153,543,613...153,550,136
JBrowse link
G S100A6 S100 calcium binding protein A6 increases expression EXP Adenosine Triphosphate results in increased expression of S100A6 mRNA CTD PMID:29733962 NCBI chr 1:153,534,599...153,536,049
Ensembl chr 1:153,534,599...153,536,244
JBrowse link
G S100P S100 calcium binding protein P increases expression EXP Adenosine Triphosphate results in increased expression of S100P mRNA CTD PMID:29733962 NCBI chr 4:6,693,878...6,697,170
Ensembl chr 4:6,693,878...6,697,170
JBrowse link
G SELL selectin L multiple interactions EXP P2RX7 protein affects the reaction [Adenosine Triphosphate results in increased secretion of SELL protein] CTD PMID:11003599 NCBI chr 1:169,690,667...169,711,620
Ensembl chr 1:169,690,665...169,711,702
JBrowse link
G SFTPA1 surfactant protein A1 multiple interactions EXP [SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]; Ozone inhibits the reaction [[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]; Ozone inhibits the reaction [SFTPA1 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]] CTD PMID:15065867 NCBI chr10:79,610,939...79,615,455
Ensembl chr10:79,610,939...79,615,455
JBrowse link
G SFTPA2 surfactant protein A2 multiple interactions EXP [SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]; Ozone inhibits the reaction [[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]; Ozone inhibits the reaction [SFTPA2 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]; SFTPA2 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines] CTD PMID:15065867 NCBI chr10:79,555,852...79,560,459
Ensembl chr10:79,555,852...79,560,407
JBrowse link
G SFTPB surfactant protein B increases secretion
multiple interactions
ISO Adenosine Triphosphate results in increased secretion of SFTPB protein
Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPB protein]
CTD PMID:11704537 PMID:14565945 NCBI chr 2:85,657,307...85,668,741
Ensembl chr 2:85,657,314...85,668,741
JBrowse link
G SFTPC surfactant protein C increases secretion
multiple interactions
ISO Adenosine Triphosphate results in increased secretion of SFTPC protein
Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPC protein]
CTD PMID:11704537 PMID:14565945 NCBI chr 8:22,157,383...22,164,479
Ensembl chr 8:22,156,913...22,164,479
JBrowse link
G SIRT1 sirtuin 1 multiple interactions ISO [SIRT1 protein results in decreased expression of UCP2 mRNA] promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate]; SIRT1 protein promotes the reaction [[Glucose results in increased abundance of Adenosine Triphosphate] which results in increased expression of INS1 protein]; SIRT1 protein promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate] CTD PMID:16366736 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SIRT3 sirtuin 3 multiple interactions ISO SIRT3 protein inhibits the reaction [Metformin results in decreased abundance of Adenosine Triphosphate] CTD PMID:23166782 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931
JBrowse link
G SLC25A14 solute carrier family 25 member 14 decreases chemical synthesis EXP SLC25A14 protein results in decreased chemical synthesis of Adenosine Triphosphate CTD PMID:20600837 NCBI chr  X:130,339,892...130,373,360
Ensembl chr  X:130,339,888...130,373,361
JBrowse link
G SLC2A1 solute carrier family 2 member 1 decreases stability EXP Adenosine Triphosphate results in decreased stability of SLC2A1 protein CTD PMID:11420438 NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893
Ensembl chr 1:42,925,353...42,958,893
JBrowse link
G SLC46A1 solute carrier family 46 member 1 multiple interactions EXP [SLC46A1 protein results in increased susceptibility to N-((5-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)propyl)thiophen-2-yl)carbonyl)glutamic acid] which results in decreased chemical synthesis of Adenosine Triphosphate CTD PMID:21879757 NCBI chr17:28,394,642...28,406,630
Ensembl chr17:28,394,642...28,407,197
JBrowse link
G SLC5A5 solute carrier family 5 member 5 multiple interactions EXP Adenosine Triphosphate inhibits the reaction [TSHB protein results in increased expression of SLC5A5 protein] CTD PMID:16439463 NCBI chr19:17,871,394...17,895,175
Ensembl chr19:17,871,945...17,895,174
JBrowse link
G SNCA synuclein alpha multiple interactions
decreases abundance
EXP GW8510 inhibits the reaction [SNCA protein results in decreased abundance of Adenosine Triphosphate]; SB 216763 inhibits the reaction [SNCA protein results in decreased abundance of Adenosine Triphosphate] CTD PMID:24989254 NCBI chr 4:89,724,099...89,838,324
Ensembl chr 4:89,700,345...89,838,315
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G SOD1 superoxide dismutase 1 increases expression ISO
EXP
Adenosine Triphosphate results in increased expression of SOD1 protein CTD PMID:16178011 PMID:22129738 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 affects chemical synthesis
decreases abundance
multiple interactions
ISO SOD2 protein affects the chemical synthesis of Adenosine Triphosphate
SOD2 gene mutant form results in decreased abundance of Adenosine Triphosphate
MK-886 promotes the reaction [SOD2 gene mutant form results in decreased abundance of Adenosine Triphosphate]
CTD PMID:20638473 PMID:25362851 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G STXBP2 syntaxin binding protein 2 multiple interactions ISO STXBP2 protein affects the reaction [F2 protein results in increased transport of Adenosine Triphosphate] CTD PMID:30696774 NCBI chr19:7,637,110...7,647,873
Ensembl chr19:7,636,881...7,647,873
JBrowse link
G SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone multiple interactions EXP Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to SUGT1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]; Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]] CTD PMID:23184943 NCBI chr13:52,652,703...52,700,909
Ensembl chr13:52,652,709...52,700,909
JBrowse link
G SYN2 synapsin II multiple interactions ISO SYN2 mutant form inhibits the reaction [Adenosine Triphosphate results in increased abundance of Calcium] CTD PMID:18701217 NCBI chr 3:12,004,366...12,192,032
Ensembl chr 3:12,004,388...12,192,032
JBrowse link
G TAC1 tachykinin precursor 1 increases secretion
multiple interactions
ISO Adenosine Triphosphate results in increased secretion of TAC1 protein
Iloprost promotes the reaction [Adenosine Triphosphate results in increased secretion of TAC1 protein]
CTD PMID:16039053 NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472
JBrowse link
G TALDO1 transaldolase 1 increases abundance ISO TALDO1 gene mutant form results in increased abundance of Adenosine Triphosphate CTD PMID:19436114 NCBI chr11:747,464...765,012
Ensembl chr11:747,415...765,012
JBrowse link
G TAS2R42 taste 2 receptor member 42 increases activity ISO Adenosine Triphosphate results in increased activity of TAS2R131 protein CTD PMID:29347925 NCBI chr12:11,185,993...11,186,937
Ensembl chr12:11,185,993...11,186,937
JBrowse link
G TIMM17A translocase of inner mitochondrial membrane 17A multiple interactions
decreases expression
EXP 1,10-phenanthroline inhibits the reaction [Adenosine Triphosphate results in decreased expression of TIMM17A protein] CTD PMID:24315374 NCBI chr 1:201,955,503...201,970,664
Ensembl chr 1:201,955,503...201,970,664
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 decreases secretion
multiple interactions
ISO Adenosine Triphosphate results in decreased secretion of TIMP1 protein
azetidine analog inhibits the reaction [Adenosine Triphosphate results in decreased secretion of TIMP1 protein]
CTD PMID:26522449 NCBI chr  X:47,582,408...47,586,789
Ensembl chr  X:47,582,408...47,586,789
JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases chemical synthesis
ISO
EXP
[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of TNF protein; Adenosine Triphosphate deficiency inhibits the reaction [TNF protein results in increased transport of Chlorides]; Adenosine Triphosphate deficiency inhibits the reaction [TNF protein results in increased transport of Potassium]; Adenosine Triphosphate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]; azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased secretion of TNF protein]
TNF protein results in decreased chemical synthesis of Adenosine Triphosphate
TNF protein promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased chemical synthesis of Adenosine Triphosphate]
[Asbestos, Amosite co-treated with TNF protein] results in increased metabolism of Adenosine Triphosphate; Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; MFN2 protein inhibits the reaction [TNF protein results in decreased chemical synthesis of Adenosine Triphosphate]; Rosiglitazone inhibits the reaction [TNF protein results in decreased chemical synthesis of Adenosine Triphosphate]; Vitamin K 3 promotes the reaction [[Asbestos, Amosite co-treated with TNF protein] results in increased metabolism of Adenosine Triphosphate]
CTD PMID:8817062 PMID:10783394 PMID:14623498 PMID:17707769 PMID:23430110 PMID:24898700 PMID:26522449 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFSF11 TNF superfamily member 11 increases abundance ISO TNFSF11 protein results in increased abundance of Adenosine Triphosphate CTD PMID:26287518 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013
JBrowse link
G TOP2A DNA topoisomerase II alpha multiple interactions
increases hydrolysis
EXP Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]; copper-thiosemicarbazone complex analog inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]; Dithiothreitol inhibits the reaction [Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]]; Emodin inhibits the reaction [TOP2A results in increased hydrolysis of Adenosine Triphosphate]; Etoposide metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]; Thiosemicarbazones analog inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]
TOP2A protein results in increased hydrolysis of Adenosine Triphosphate; TOP2A results in increased hydrolysis of Adenosine Triphosphate
CTD PMID:20855424 PMID:26982206 PMID:27533850 PMID:29272108 NCBI chr17:40,388,525...40,417,902
Ensembl chr17:40,388,525...40,417,896
JBrowse link
G TOP2B DNA topoisomerase II beta multiple interactions
increases hydrolysis
EXP cannabidiol hydroxyquinone inhibits the reaction [TOP2B protein results in increased hydrolysis of Adenosine Triphosphate]; Cannabidiol metabolite inhibits the reaction [TOP2B protein results in increased hydrolysis of Adenosine Triphosphate] CTD PMID:29272108 NCBI chr 3:25,597,905...25,664,907
Ensembl chr 3:25,597,905...25,664,907
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP TP53 protein inhibits the reaction [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] CTD PMID:21042727 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 decreases activity ISO Adenosine Triphosphate results in decreased activity of TRPM4 protein CTD PMID:16966582 PMID:17188667 NCBI chr19:49,157,792...49,211,841
Ensembl chr19:49,157,741...49,211,836
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions ISO [Capsaicin binds to and affects the activity of TRPV1 protein] which results in increased secretion of Adenosine Triphosphate CTD PMID:19860742 NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411
JBrowse link
G TSHB thyroid stimulating hormone subunit beta multiple interactions EXP Adenosine Triphosphate inhibits the reaction [TSHB protein results in increased expression of SLC5A5 protein] CTD PMID:16439463 NCBI chr 1:115,029,826...115,035,935
Ensembl chr 1:115,029,826...115,034,302
Ensembl chr 1:115,029,826...115,034,302
JBrowse link
G TXN thioredoxin increases expression EXP Adenosine Triphosphate results in increased expression of TXN protein CTD PMID:22129738 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
JBrowse link
G TXNIP thioredoxin interacting protein increases activity ISO Adenosine Triphosphate results in increased activity of TXNIP mRNA CTD PMID:21832250 NCBI chr 1:145,992,435...145,996,579
Ensembl chr 1:145,992,435...145,996,579
JBrowse link
G UCP1 uncoupling protein 1 multiple interactions
decreases abundance
ISO
EXP
Adenosine Triphosphate inhibits the reaction [UCP1 protein results in increased transport of Protons]
UCP1 results in decreased abundance of Adenosine Triphosphate
UCP1 protein promotes the reaction [PPARG protein mutant form results in decreased abundance of Adenosine Triphosphate]; UCP1 protein promotes the reaction [rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]]
CTD PMID:12734183 PMID:26670611 NCBI chr 4:140,555,770...140,568,961
Ensembl chr 4:140,559,431...140,568,961
JBrowse link
G UCP2 uncoupling protein 2 multiple interactions EXP
ISO
Adenosine Triphosphate inhibits the reaction [UCP2 protein results in increased transport of Protons]
[SIRT1 protein results in decreased expression of UCP2 mRNA] promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate]
CTD PMID:12734183 PMID:16366736 NCBI chr11:73,974,671...73,983,202
Ensembl chr11:73,974,672...73,983,246
JBrowse link
G UCP3 uncoupling protein 3 multiple interactions EXP Adenosine Triphosphate inhibits the reaction [UCP3 protein results in increased transport of Protons] CTD PMID:12734183 NCBI chr11:74,000,277...74,009,085
Ensembl chr11:74,000,277...74,009,085
JBrowse link
G VDAC1 voltage dependent anion channel 1 multiple interactions EXP VDAC1 mutant form inhibits the reaction [chromium hexavalent ion results in decreased abundance of Adenosine Triphosphate] CTD PMID:22858589 NCBI chr 5:133,971,871...134,070,987
Ensembl chr 5:133,971,871...134,004,975
JBrowse link
atropine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
EXP Atropine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atropine results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions EXP [Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA CTD PMID:17390078 NCBI chr 9:130,713,881...130,887,675
Ensembl chr 9:130,713,016...130,887,675
JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions EXP
ISO
Atropine inhibits the reaction [[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine]; Atropine inhibits the reaction [Carbachol results in increased metabolism of and results in increased secretion of ACHE protein]; Atropine inhibits the reaction [Paraoxon results in increased expression of ACHE protein]
[Atropine co-treated with Obidoxime Chloride] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; [tariquidar co-treated with asoxime chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with cucurbit(7)uril] co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]
CTD PMID:2241428 PMID:10421444 PMID:17963125 PMID:20105433 PMID:21600273 PMID:21787676 PMID:22783142 PMID:23047022 PMID:24881594 PMID:26751814 PMID:31794810 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ADCY5 adenylate cyclase 5 increases response to substance ISO ADCY5 protein results in increased susceptibility to Atropine CTD PMID:12869393 NCBI chr 3:123,282,296...123,449,090
Ensembl chr 3:123,282,296...123,449,090
Ensembl chr 3:123,282,296...123,449,090
JBrowse link
G AQP5 aquaporin 5 multiple interactions ISO Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein] CTD PMID:26208470 NCBI chr12:49,961,855...49,965,682
Ensembl chr12:49,961,872...49,965,682
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the expression of BAX mRNA] CTD PMID:21971501 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCAR1 BCAR1 scaffold protein, Cas family member multiple interactions EXP Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]] CTD PMID:10537051 NCBI chr16:75,228,181...75,268,007
Ensembl chr16:75,228,181...75,268,053
JBrowse link
G BCHE butyrylcholinesterase multiple interactions ISO
EXP
[Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein
[BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX
CTD PMID:17963125 PMID:22981459 NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462
JBrowse link
G BDKRB2 bradykinin receptor B2 multiple interactions ISO BDKRB2 affects the susceptibility to [Propranolol co-treated with Atropine] CTD PMID:10614985 NCBI chr14:96,204,839...96,244,164
Ensembl chr14:96,204,679...96,244,166
JBrowse link
G BMP6 bone morphogenetic protein 6 multiple interactions ISO Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of BMP6 mRNA] CTD PMID:18472332 NCBI chr 6:7,726,099...7,881,728
Ensembl chr 6:7,726,099...7,881,728
JBrowse link
G CACNA1E calcium voltage-gated channel subunit alpha1 E multiple interactions ISO Atropine inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]] CTD PMID:12663092 NCBI chr 1:181,317,712...181,808,084
Ensembl chr 1:181,317,690...181,808,084
JBrowse link
G CALCA calcitonin related polypeptide alpha affects activity ISO Atropine affects the activity of CALCA protein CTD PMID:7906887 PMID:10075105 NCBI chr11:14,966,668...14,972,361
Ensembl chr11:14,966,668...14,972,354
JBrowse link
G CASP3 caspase 3 increases expression ISO Atropine results in increased expression of CASP3 mRNA CTD PMID:19815060 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CCL5 C-C motif chemokine ligand 5 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 protein] CTD PMID:22245128 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
JBrowse link
G CCNA1 cyclin A1 increases expression
multiple interactions
EXP Atropine results in increased expression of CCNA1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNA1 mRNA
CTD PMID:17390078 NCBI chr13:36,430,488...36,442,870
Ensembl chr13:36,431,520...36,442,870
JBrowse link
G CCND3 cyclin D3 multiple interactions EXP [Parathion co-treated with Atropine] results in increased expression of CCND3 mRNA CTD PMID:17390078 NCBI chr 6:41,934,933...42,048,894
Ensembl chr 6:41,934,933...42,050,357
Ensembl chr 6:41,934,933...42,050,357
JBrowse link
G CCNE1 cyclin E1 increases expression
multiple interactions
EXP Atropine results in increased expression of CCNE1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA
CTD PMID:17390078 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CCNE2 cyclin E2 multiple interactions
increases expression
EXP [Parathion co-treated with Atropine] results in increased expression of CCNE2 mRNA
Atropine results in increased expression of CCNE2 mRNA
CTD PMID:17390078 NCBI chr 8:94,880,224...94,896,671
Ensembl chr 8:94,879,770...94,896,678
JBrowse link
G CD40 CD40 molecule multiple interactions EXP Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein] CTD PMID:16879495 NCBI chr20:46,118,242...46,129,858
Ensembl chr20:46,118,278...46,129,863
JBrowse link
G CDC20 cell division cycle 20 multiple interactions
increases expression
EXP [Parathion co-treated with Atropine] results in increased expression of CDC20 mRNA
Atropine results in increased expression of CDC20 mRNA
CTD PMID:17390078 NCBI chr 1:43,358,981...43,363,203
Ensembl chr 1:43,358,981...43,363,203
JBrowse link
G CDC6 cell division cycle 6 multiple interactions EXP [Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA CTD PMID:17390078 NCBI chr17:40,287,878...40,304,657
Ensembl chr17:40,287,879...40,304,657
JBrowse link
G CDK1 cyclin dependent kinase 1 multiple interactions
increases expression
EXP [Parathion co-treated with Atropine] results in increased expression of CDK1 mRNA
Atropine results in increased expression of CDK1 mRNA
CTD PMID:17390078 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CES1 carboxylesterase 1 multiple interactions EXP Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] CTD PMID:9311626 NCBI chr16:55,802,851...55,833,127
Ensembl chr16:55,802,851...55,833,337
JBrowse link
G CHRM1 cholinergic receptor muscarinic 1 multiple interactions
decreases activity
ISO
EXP
Atropine binds to and results in decreased activity of CHRM1 protein; Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
Atropine results in decreased activity of CHRM1 protein
Atropine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]
CTD PMID:16439611 PMID:18316702 PMID:31830555 NCBI chr11:62,908,675...62,921,861
Ensembl chr11:62,908,679...62,921,807
JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 multiple interactions EXP Atropine binds to and results in decreased activity of CHRM2 protein CTD PMID:15140916 NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,669...137,020,255
JBrowse link
G CHRM3 cholinergic receptor muscarinic 3 multiple interactions
decreases activity
EXP Atropine binds to and results in decreased activity of CHRM3 protein; Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]
Atropine results in decreased activity of CHRM3 protein
CTD PMID:15140916 PMID:20708676 PMID:31830555 NCBI chr 1:239,386,565...239,915,450
Ensembl chr 1:239,386,565...239,915,452
JBrowse link
G CHRM4 cholinergic receptor muscarinic 4 multiple interactions
affects binding
EXP [WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Atropine binds to CHRM4 protein] CTD PMID:16709648 NCBI chr11:46,383,789...46,391,776
Ensembl chr11:46,385,098...46,386,608
JBrowse link
G CHRM5 cholinergic receptor muscarinic 5 multiple interactions EXP Atropine inhibits the reaction [Acetylcholine results in increased activity of CHRM5 protein] CTD PMID:31323226 NCBI chr15:33,968,497...34,067,458
Ensembl chr15:33,968,497...34,067,458
Ensembl chr15:33,968,497...34,067,458
JBrowse link
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
affects binding
EXP
ISO
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]]
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
CTD PMID:15733544 PMID:21791372 NCBI chr20:63,343,223...63,375,471
Ensembl chr20:63,343,223...63,378,401
JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit affects binding
multiple interactions
EXP
ISO
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:15733544 PMID:21791372 NCBI chr 1:154,567,778...154,584,708
Ensembl chr 1:154,567,778...154,580,013
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein] CTD PMID:21971501 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CRH corticotropin releasing hormone multiple interactions ISO
EXP
Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]
[Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH protein
CTD PMID:12039681 PMID:12906840 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein mutant form]; Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein] CTD PMID:17390078 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 protein] CTD PMID:22245128 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
JBrowse link
G DVL2 dishevelled segment polarity protein 2 multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of DVL2 protein] CTD PMID:17390078 NCBI chr17:7,225,341...7,234,544
Ensembl chr17:7,225,342...7,234,517
JBrowse link
G EDN1 endothelin 1 multiple interactions EXP EDN1 protein results in decreased activity of [Atropine co-treated with Histamine] CTD PMID:12906840 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of EGFR protein] CTD PMID:17390078 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EGR1 early growth response 1 multiple interactions ISO Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA] CTD PMID:7968354 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G EGR2 early growth response 2 multiple interactions ISO Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA] CTD PMID:7968354 NCBI chr10:62,811,996...62,819,167
Ensembl chr10:62,811,996...62,919,900
JBrowse link
G EZR ezrin multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of EZR protein] CTD PMID:17390078 NCBI chr 6:158,765,744...158,819,368
Ensembl chr 6:158,765,741...158,819,368
JBrowse link
G F2 coagulation factor II, thrombin multiple interactions ISO [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in decreased expression of F2 mRNA; [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased activity of F2 protein CTD PMID:30515700 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506
Ensembl chr11:46,719,196...46,739,506
JBrowse link
G F2R coagulation factor II thrombin receptor multiple interactions ISO [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased expression of F2R protein CTD PMID:30515700 NCBI chr 5:76,716,126...76,735,770
Ensembl chr 5:76,716,126...76,735,770
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO
EXP
Atropine results in increased expression of FOS protein
Atropine inhibits the reaction [Paraoxon results in increased expression of FOS mRNA]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased expression of FOS protein]; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]
CTD PMID:7968354 PMID:8281324 PMID:21787676 PMID:21971501 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G GHRL ghrelin and obestatin prepropeptide multiple interactions ISO Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein] CTD PMID:16959836 NCBI chr 3:10,285,666...10,292,947
Ensembl chr 3:10,285,666...10,292,947
JBrowse link
G GLRA1 glycine receptor alpha 1 multiple interactions EXP Atropine binds to and results in decreased activity of GLRA1 protein CTD PMID:15081878 NCBI chr 5:151,822,513...151,924,851
Ensembl chr 5:151,822,513...151,924,842
Ensembl chr 5:151,822,513...151,924,842
JBrowse link
G GRM4 glutamate metabotropic receptor 4 multiple interactions EXP Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr 6:34,018,643...34,155,622
Ensembl chr 6:34,018,643...34,155,622
Ensembl chr 6:34,018,643...34,155,622
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 protein] CTD PMID:22245128 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B protein] CTD PMID:22245128 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions ISO [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 mRNA]; [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 protein] CTD PMID:22245128 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of JUN protein] CTD PMID:21971501 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] CTD PMID:7968354 NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315
JBrowse link
G KCNJ3 potassium inwardly rectifying channel subfamily J member 3 multiple interactions EXP Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr 2:154,698,695...154,858,354
Ensembl chr 2:154,697,855...154,858,354
JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of KIT protein] CTD PMID:17390078 NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,918...54,740,715
JBrowse link
G LTF lactotransferrin multiple interactions EXP Atropine inhibits the reaction [methylcholine results in increased secretion of LTF protein] CTD PMID:11112886 NCBI chr 3:46,435,645...46,485,234
Ensembl chr 3:46,435,645...46,485,234
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK1 protein] CTD PMID:21971501 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK14 protein] CTD PMID:21971501 NCBI chr 6:36,027,711...36,122,964
Ensembl chr 6:36,027,677...36,111,236
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK3 protein] CTD PMID:21971501 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK8 protein] CTD PMID:21971501 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MCM4 minichromosome maintenance complex component 4 multiple interactions
increases expression
EXP [Parathion co-treated with Atropine] results in increased expression of MCM4 mRNA
Atropine results in increased expression of MCM4 mRNA
CTD PMID:17390078 NCBI chr 8:47,960,941...47,978,160
Ensembl chr 8:47,960,185...47,978,160
JBrowse link
G MCM6 minichromosome maintenance complex component 6 increases expression
multiple interactions
EXP Atropine results in increased expression of MCM6 mRNA
[Parathion co-treated with Atropine] results in increased expression of MCM6 mRNA
CTD PMID:17390078 NCBI chr 2:135,839,626...135,876,443
Ensembl chr 2:135,839,626...135,876,443
JBrowse link
G NEFH neurofilament heavy affects expression ISO Atropine affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr22:29,480,218...29,491,390
Ensembl chr22:29,480,218...29,491,390
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 increases expression EXP Atropine results in increased expression of NLRP3 mRNA CTD PMID:28138970 NCBI chr 1:247,416,163...247,448,823
Ensembl chr 1:247,416,156...247,449,108
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Atropine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Atropine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] CTD PMID:15610444 PMID:16944022 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOTCH4 notch receptor 4 multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of NOTCH4 protein] CTD PMID:17390078 NCBI chr 6:32,194,843...32,224,067
Ensembl chr 6:32,194,843...32,224,067
JBrowse link
G NPPA natriuretic peptide A affects activity ISO Atropine affects the activity of NPPA protein modified form CTD PMID:1363893 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G OPRL1 opioid related nociceptin receptor 1 multiple interactions ISO Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] CTD PMID:12007927 NCBI chr20:64,080,082...64,100,643
Ensembl chr20:64,080,082...64,100,643
JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions EXP Atropine inhibits the reaction [Malathion results in increased expression of PCNA]; Atropine inhibits the reaction [Parathion results in increased expression of PCNA] CTD PMID:12762645 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PNOC prepronociceptin multiple interactions ISO Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] CTD PMID:12007927 NCBI chr 8:28,316,979...28,343,355
Ensembl chr 8:28,316,986...28,343,355
JBrowse link
G POMC proopiomelanocortin multiple interactions ISO Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein] CTD PMID:7588217 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO [Atropine co-treated with Glucose] binds to PPARA protein; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Atropine affects the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA] CTD PMID:15104355 PMID:15610444 PMID:16259740 PMID:16804302 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G PTK2 protein tyrosine kinase 2 multiple interactions EXP Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]] CTD PMID:10537051 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216
JBrowse link
G PXN paxillin multiple interactions EXP Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]] CTD PMID:10537051 NCBI chr12:120,210,447...120,265,737
Ensembl chr12:120,210,439...120,265,771
JBrowse link
G RAC3 Rac family small GTPase 3 multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of RAC3 protein] CTD PMID:17390078 NCBI chr17:82,031,678...82,034,204
Ensembl chr17:82,031,678...82,034,204
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of RELA protein] CTD PMID:21971501 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RHOA ras homolog family member A multiple interactions EXP Atropine inhibits the reaction [Parathion results in increased expression of RHOA protein] CTD PMID:17390078 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,145...49,412,998
JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions EXP Atropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 PMID:21641380 NCBI chr 6:160,121,808...160,160,590
Ensembl chr 6:160,121,815...160,158,718
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Atropine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:16263091 PMID:21599003 PMID:23770354 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G SLC22A3 solute carrier family 22 member 3 increases uptake
multiple interactions
EXP SLC22A3 protein results in increased uptake of Atropine
Atropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]
CTD PMID:16263091 NCBI chr 6:160,348,378...160,454,982
Ensembl chr 6:160,348,378...160,452,577