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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:anti-arrhythmia drug
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Accession:CHEBI:38070 term browser browse the term
Definition:A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
Synonyms:related_synonym: anti-arrhythmia agent;   antiarrhythmic agent


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atenolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin multiple interactions EXP Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] CTD PMID:6103674 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
atropine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
JBrowse link
digoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
increases response to substance
EXP [ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin]; [Verapamil results in decreased activity of ABCB1 protein] which affects the transport of Digoxin; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of ALB mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of DAO mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of EBF3 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GABRQ mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GLRA1 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of KLK6 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of MAB21L2 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC10A4 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC18A2 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of TTR mRNA]; MYL9 protein modified form affects the reaction [ABCB1 protein affects the transport of Digoxin analog]
ABCB1 gene mutant form results in increased susceptibility to Digoxin; ABCB1 mutant form results in increased susceptibility to Digoxin
CTD PMID:16594604, PMID:20510202, PMID:23186803, PMID:25419811 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
G ALB albumin multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of ALB mRNA] CTD PMID:25419811 NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709
JBrowse link
G DAO D-amino acid oxidase multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of DAO mRNA] CTD PMID:25419811 NCBI chr26:18,032,663...18,057,277
Ensembl chr26:18,033,392...18,057,238
JBrowse link
G EBF3 EBF transcription factor 3 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of EBF3 mRNA] CTD PMID:25419811 NCBI chr28:38,489,635...38,601,800
Ensembl chr28:38,491,047...38,602,022
JBrowse link
G GABRQ gamma-aminobutyric acid type A receptor subunit theta multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GABRQ mRNA] CTD PMID:25419811 NCBI chr  X:120,607,815...120,630,251
Ensembl chr  X:120,607,686...120,628,343
JBrowse link
G GLRA1 glycine receptor alpha 1 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GLRA1 mRNA] CTD PMID:25419811 NCBI chr 4:57,443,094...57,541,494
Ensembl chr 4:57,443,999...57,528,376
JBrowse link
G INS insulin multiple interactions EXP [INS protein co-treated with Glucose] results in increased susceptibility to Digoxin; [INS protein co-treated with Glucose] results in increased uptake of Digoxin CTD PMID:140932, PMID:1013176 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
JBrowse link
G KLK6 kallikrein related peptidase 6 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of KLK6 mRNA] CTD PMID:25419811 NCBI chr 1:105,902,147...105,907,585 JBrowse link
G MAB21L2 mab-21 like 2 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of MAB21L2 mRNA] CTD PMID:25419811 NCBI chr15:48,538,912...48,541,651
Ensembl chr15:48,539,955...48,541,034
JBrowse link
G MYL9 myosin light chain 9 multiple interactions EXP MYL9 protein modified form affects the reaction [ABCB1 protein affects the transport of Digoxin analog] CTD PMID:20510202 NCBI chr24:25,322,800...25,329,937
Ensembl chr24:25,322,800...25,329,932
JBrowse link
G MYLK myosin light chain kinase multiple interactions EXP [ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin] CTD PMID:20510202 NCBI chr33:26,663,991...26,867,370
Ensembl chr33:26,664,800...26,843,181
JBrowse link
G SLC10A4 solute carrier family 10 member 4 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC10A4 mRNA] CTD PMID:25419811 NCBI chr13:44,293,956...44,299,529
Ensembl chr13:44,277,094...44,299,732
JBrowse link
G SLC18A2 solute carrier family 18 member A2 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC18A2 mRNA] CTD PMID:25419811 NCBI chr28:27,731,709...27,809,341
Ensembl chr28:27,731,004...27,767,993
JBrowse link
G TTR transthyretin multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of TTR mRNA] CTD PMID:25419811 NCBI chr 7:57,940,354...57,947,084
Ensembl chr 7:57,914,381...57,947,058
JBrowse link
felodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Felodipine results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
JBrowse link
glyburide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator decreases activity EXP Glyburide results in decreased activity of CFTR protein CTD PMID:15496164 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977
JBrowse link
losartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin increases expression EXP Losartan results in increased expression of REN protein CTD PMID:10483973 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
losartan carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin increases expression EXP losartan carboxylic acid results in increased expression of REN protein CTD PMID:10483973 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
mexiletine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases response to substance EXP ABCB1 mutant form results in increased susceptibility to Mexiletine CTD PMID:16594604 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
ouabain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin decreases secretion
multiple interactions
EXP Ouabain results in decreased secretion of REN protein
Vanadates inhibits the reaction [Ouabain results in decreased secretion of REN protein]
CTD PMID:6093556 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
propranolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB2 adrenoceptor beta 2 multiple interactions EXP [Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased secretion of Norepinephrine CTD PMID:2884805 NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298
JBrowse link
G NPPA natriuretic peptide A increases expression EXP Propranolol results in increased expression of NPPA protein CTD PMID:2566282 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385
JBrowse link
G REN renin multiple interactions
decreases activity
EXP Propranolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]
Propranolol results in decreased activity of REN protein
CTD PMID:2566282, PMID:6103674 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
G VIP vasoactive intestinal peptide decreases expression EXP Propranolol results in decreased expression of VIP protein CTD PMID:2566282 NCBI chr 1:42,941,655...42,950,160
Ensembl chr 1:42,941,224...42,950,700
JBrowse link
ranolazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 affects expression
multiple interactions
EXP Ranolazine affects the expression of ATP2A2 protein
[Ranolazine co-treated with Enalapril] affects the expression of ATP2A2 protein; [Ranolazine co-treated with Metoprolol] affects the expression of ATP2A2 protein
CTD PMID:18820026 NCBI chr26:8,148,181...8,209,392
Ensembl chr26:8,148,236...8,209,388
JBrowse link
G EGR1 early growth response 1 multiple interactions
affects expression
EXP [Ranolazine co-treated with Enalapril] affects the expression of EGR1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of EGR1 protein
Ranolazine affects the expression of EGR1 protein
CTD PMID:18820026 NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575
JBrowse link
G GATA4 GATA binding protein 4 affects expression
multiple interactions
EXP Ranolazine affects the expression of GATA4 protein
[Ranolazine co-treated with Enalapril] affects the expression of GATA4 protein; [Ranolazine co-treated with Metoprolol] affects the expression of GATA4 protein
CTD PMID:18820026 NCBI chr25:26,126,172...26,211,474
Ensembl chr25:26,127,853...26,182,989
JBrowse link
G NAB1 NGFI-A binding protein 1 affects expression
multiple interactions
EXP Ranolazine affects the expression of NAB1 protein
[Ranolazine co-treated with Enalapril] affects the expression of NAB1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of NAB1 protein
CTD PMID:18820026 NCBI chr37:1,207,619...1,243,546
Ensembl chr37:1,207,638...1,241,610
JBrowse link
G SLC8A1 solute carrier family 8 member A1 affects expression
multiple interactions
EXP Ranolazine affects the expression of SLC8A1 protein
[Ranolazine co-treated with Enalapril] affects the expression of SLC8A1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of SLC8A1 protein
CTD PMID:18820026 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700
JBrowse link
verapamil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP [Verapamil results in decreased activity of ABCB1 protein] which affects the transport of Digoxin CTD PMID:20510202 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 227
    role 227
      application 195
        pharmaceutical 192
          drug 192
            cardiovascular drug 72
              anti-arrhythmia drug 26
                (2R,3S,2'R)-nadolol + 0
                (S)-timolol (anhydrous) + 0
                (S)-timolol hemihydrate 0
                (S)-timolol maleate 0
                2-(4-hydroxyphenyl)ethanol + 0
                3'''-O-acetyldigitoxin 0
                N-acetylprocainamide 0
                acebutolol 0
                acebutolol hydrochloride 0
                acetylstrophanthidin 0
                adenosine + 0
                alprenolol + 0
                atenolol + 1
                atropine + 1
                beclomethasone dipropionate 0
                bepridil + 0
                bevantolol + 0
                bevantolol hydrochloride + 0
                bisoprolol + 0
                bretylium + 0
                bretylium tosylate 0
                carteolol 0
                carteolol hydrochloride 0
                cinalukast 0
                clidinium + 0
                clidinium bromide 0
                deslanoside 0
                devapamil 0
                digoxin + 14
                disopyramide + 0
                dofetilide 0
                dronedarone 0
                encainide + 0
                encainide hydrochloride 0
                enprofylline + 0
                esmolol + 0
                esmolol hydrochloride 0
                ethylisopropylamiloride 0
                felodipine 1
                flecainide 0
                flecainide acetate 0
                glyburide 1
                levosimendan 0
                lidocaine + 0
                lidocaine hydrochloride + 0
                lidocaine hydrochloride monohydrate 0
                losartan + 1
                magnesium sulfate + 0
                metipranolol 0
                metipranolol hydrochloride 0
                mexiletine + 1
                mexiletine hydrochloride 0
                montelukast + 0
                moricizine + 0
                moricizine hydrochloride 0
                nadolol 0
                norverapamil 0
                ouabain 1
                pilsicainide 0
                practolol 0
                procainamide + 0
                procainamide hydrochloride 0
                propafenone 0
                propafenone hydrochloride 0
                propranolol + 4
                quinidine + 0
                ranolazine 5
                sotalol 0
                sotalol hydrochloride 0
                tedisamil 0
                tocainide 0
                trans-piceid 0
                verapamil 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.