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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cyanazine
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Accession:CHEBI:38069 term browser browse the term
Definition:A chloro-1,3,5-triazine that is 2-chloro-1,3,5-triazine substituted by an ethyl amino and a (2-cyanopropan-2-yl)amino group at positions 6 and 4 respectively.
Synonyms:related_synonym: 2-([4-chloro-6-(ethylamino)-1,3,5-triazin-2-yl]amino)-2-methylpropanenitrile;   2-Chloro-4-(1-cyano-1-methylethylamino)-6-ethylamine-1,3,5-triazine;   2-[[4-chloro-6-(ethylamino)-s-triazin-2-yl]amino]-2-methylpropionitrile;   2-chloro-4-(1-cyano-1-methylethylamino)-6-ethylamino-1,3,5-triazine;   Bladex;   Formula=C9H13ClN6;   Fortrol;   InChI=1S/C9H13ClN6/c1-4-12-7-13-6(10)14-8(15-7)16-9(2,3)5-11/h4H2,1-3H3,(H2,12,13,14,15,16);   InChIKey=MZZBPDKVEFVLFF-UHFFFAOYSA-N;   SMILES=CCNc1nc(Cl)nc(NC(C)(C)C#N)n1
 alt_id: CHEBI:23421;   CHEBI:34658
 xref: Beilstein:615509;   CAS:21725-46-2;   KEGG:C14299
 xref_mesh: MESH:C007168
 xref: PMID:16882534;   PMID:23762632;   PMID:24607126;   PMID:24631619;   PPDB:185;   Pesticides:cyanazine;   Reaxys:615509;   UM-BBD_compID:c0176


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cyanazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA2A adrenoceptor alpha 2A affects binding
affects activity		 ISO cyanazine binds to ADRA2A protein
cyanazine affects the activity of ADRA2A protein		 CTD PMID:11071396 NCBI chr10:111,077,029...111,080,907
Ensembl chr10:111,077,029...111,080,907 		JBrowse link
G DBH dopamine beta-hydroxylase increases expression ISO cyanazine results in increased expression of DBH protein CTD PMID:14550852 NCBI chr 9:133,636,363...133,659,329
Ensembl chr 9:133,636,363...133,659,329 		JBrowse link
G DRD2 dopamine receptor D2 affects activity ISO cyanazine affects the activity of DRD2 protein CTD PMID:11071396 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691 		JBrowse link
G ESR1 estrogen receptor 1 affects binding
multiple interactions		 EXP cyanazine binds to ESR1 protein
cyanazine inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]		 CTD PMID:8858116 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 affects binding EXP cyanazine binds to ESR2 protein CTD PMID:12224631 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 affects expression EXP cyanazine affects the expression of GPER1 mRNA CTD PMID:26955487 NCBI chr 7:1,087,118...1,093,810
Ensembl chr 7:1,082,208...1,093,815 		JBrowse link
G PDE4A phosphodiesterase 4A decreases activity EXP cyanazine results in decreased activity of PDE4A protein CTD PMID:21251949 NCBI chr19:10,416,773...10,469,631
Ensembl chr19:10,416,773...10,469,630 		JBrowse link
G PDE5A phosphodiesterase 5A affects activity EXP cyanazine affects the activity of PDE5 protein CTD PMID:21251949 NCBI chr 4:119,494,403...119,628,804
Ensembl chr 4:119,494,397...119,628,804 		JBrowse link
G PRL prolactin increases expression ISO cyanazine metabolite results in increased expression of PRL protein; cyanazine results in increased expression of PRL protein CTD PMID:11071396 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
G TH tyrosine hydroxylase increases expression ISO cyanazine results in increased expression of TH protein CTD PMID:14550852 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      biological role 25929
        xenobiotic 20368
          cyanazine 10
            2-\{[4-chloro-6-(ethylamino)-1,3,5-triazin-2-yl]amino\}-2-methylbutanenitrile + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    main group molecular entity 25834
                      s-block molecular entity 25166
                        hydrogen molecular entity 24765
                          hydrides 22965
                            inorganic hydride 20483
                              pnictogen hydride 20424
                                nitrogen hydride 20200
                                  azane 19942
                                    ammonia 19941
                                      organic amino compound 19941
                                        polyamine 9568
                                          diamine 9505
                                            diamino-1,3,5-triazine 5139
                                              1,3,5-triazinylamino nitrile 10
                                                cyanazine 10
                                                  2-\{[4-chloro-6-(ethylamino)-1,3,5-triazin-2-yl]amino\}-2-methylbutanenitrile + 0
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