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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:antimalarial
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Accession:CHEBI:38068 term browser browse the term
Definition:A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.
Synonyms:related_synonym: antimalarials

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chloroquine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions EXP Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein] CTD PMID:30287338 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773 		JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 multiple interactions EXP Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of HSP70 protein] CTD PMID:17727805 NCBI chr 4:88,970,592...88,973,109
Ensembl chr 4:88,970,591...88,985,586 		JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPD1 protein] CTD PMID:17727805 NCBI chr15:101,360,355...101,373,498
Ensembl chr15:101,360,094...101,373,527 		JBrowse link
G IFNB1 interferon beta 1 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFNB1 mRNA] CTD PMID:27079946 NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495 		JBrowse link
G IFNG interferon gamma multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFNG mRNA] CTD PMID:27079946 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752 		JBrowse link
G IL12B interleukin 12B multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL12B mRNA] CTD PMID:27079946 NCBI chr16:64,143,268...64,158,929
Ensembl chr16:64,147,247...64,158,952 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL6 mRNA] CTD PMID:27079946 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263 		JBrowse link
G IRF7 interferon regulatory factor 7 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IRF7 mRNA] CTD PMID:27079946 NCBI chr 2:372,235...375,572
Ensembl chr 2:371,606...375,381 		JBrowse link
G ISG15 ISG15 ubiquitin like modifier multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of ISG15 mRNA] CTD PMID:27079946 NCBI chr 6:63,363,201...63,364,211
Ensembl chr 6:63,363,173...63,364,208 		JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL1B mRNA] CTD PMID:27079946
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein] CTD PMID:30287338 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,159...14,241,197 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of RELA protein] CTD PMID:27079946 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471 		JBrowse link
G SQSTM1 sequestosome 1 increases expression
multiple interactions		 EXP Chloroquine results in increased expression of SQSTM1 protein
Chloroquine inhibits the reaction [ochratoxin A results in decreased expression of SQSTM1 protein]		 CTD PMID:30287338 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,768...78,784,256 		JBrowse link
G TLR7 toll like receptor 7 multiple interactions EXP Chloroquine affects the localization of and results in decreased activity of TLR7 protein CTD PMID:27079946 NCBI chr  X:9,573,178...9,576,987 JBrowse link
dihydroartemisinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator increases expression EXP dihydroartemisinin results in increased expression of BAX mRNA CTD PMID:29309768 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP dihydroartemisinin results in decreased expression of BCL2 mRNA CTD PMID:29309768 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879 		JBrowse link
G CASP3 caspase 3 increases expression EXP dihydroartemisinin results in increased expression of CASP3 mRNA CTD PMID:29309768 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases phosphorylation EXP dihydroartemisinin results in decreased phosphorylation of MAPK1 protein CTD PMID:29309768 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation EXP dihydroartemisinin results in decreased phosphorylation of MAPK3 protein CTD PMID:29309768 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567 		JBrowse link
doxycycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1A2 solute carrier organic anion transporter family member 1A2 increases uptake
multiple interactions		 EXP SLCO1A2 protein results in increased uptake of Doxycycline
Doxycycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Doxycycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]		 CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,037,218...52,131,789 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 875
    role 855
      biological role 855
        antimicrobial agent 230
          antimicrobial drug 53
            antiprotozoal drug 27
              antiplasmodial drug 19
                antimalarial 19
                  (+)-(11R,2'S)-erythro-mefloquine + 0
                  (+)-artemisinin + 0
                  (-)-(11S,2'R)-erythro-mefloquine + 0
                  (R)-7-butyl-6,8-dihydroxy-3-[(3E)-pent-3-en-1-yl]-3,4-dihydroisochromen-1-one 0
                  2',4'-dihydroxy-3'-(2-hydroxy benzyl)-6'-methoxy chalcone 0
                  3,15-di-O-acetylbruceolide 0
                  3-(Z)-caffeoyllupeol 0
                  5,7,3'-trihydroxy-4',5'-(2'''',2''''-dimethylpyran)-8,2'-di(3-methyl-2-butenyl)-(2S)-flavanone 0
                  5-O-methylcelebixanthone 0
                  7-deacetylgedunin 0
                  8-azahypoxanthine 0
                  E64 0
                  Eunicea sesquiterpenoid 2 0
                  Eunicea sesquiterpenoid 3 0
                  WLL-vs 0
                  acedapsone 0
                  amburoside A 0
                  amodiaquine + 0
                  artemether 0
                  arterolane 0
                  arterolane maleate 0
                  artesunate 0
                  atovaquone 0
                  bauhinoxepin F 0
                  bauhinoxepin I 0
                  bauhinoxepin J 0
                  betulinic acid + 0
                  bidebiline C 0
                  bidebiline D 0
                  bielschowskysin 0
                  bipinnatone A 0
                  bipinnatone B 0
                  borrelidin 0
                  bromophycolide A 0
                  bruceolide + 0
                  caesalpinin C 0
                  caesalpinin D 0
                  caesalpinin F 0
                  callophycoic acid A 0
                  callophycoic acid B 0
                  callophycoic acid C 0
                  callophycoic acid D 0
                  callophycoic acid E 0
                  callophycoic acid F 0
                  callophycoic acid G 0
                  callophycoic acid H 0
                  callophycol A 0
                  callophycol B 0
                  caribenol A 0
                  caribenol B 0
                  caseargrewiin A 0
                  caseargrewiin B 0
                  caseargrewiin C 0
                  caseargrewiin D 0
                  cassiarin A 0
                  cassiarin B 0
                  celebixanthone + 0
                  chloroquine + 14
                  cochinchinone C 0
                  conessine 0
                  cordyheptapeptide A 0
                  cordyol C 0
                  crambescidin 800 0
                  cryptolepine 0
                  cycloguanil + 0
                  dapsone + 0
                  dehydroemetine 0
                  dihydroartemisinin 5
                  dioncopeltine A 0
                  dioncophylline A 0
                  dioncophylline C 0
                  diuvaretin 0
                  docetaxel anhydrous + 0
                  doxycycline + 1
                  dragomabin 0
                  dragonamide A 0
                  emetine + 0
                  emetine dihydrochloride + 0
                  emetine dihydrochloride hydrate 0
                  eurycomanone 0
                  exiguaflavanone A 0
                  exiguaflavanone B 0
                  gedunin + 0
                  gutolactone 0
                  hirsutellide A 0
                  hydroxychloroquine 0
                  isariotin F 0
                  isonordoperoxide 0
                  lactucin + 0
                  lactucopicrin 0
                  leachianone A 0
                  longirostrerone A 0
                  longirostrerone B 0
                  longirostrerone C 0
                  lumefantrine 0
                  lycorine 0
                  manzamine A + 0
                  mefloquine 0
                  methylene blue 0
                  minquartynoic acid 0
                  mollicellin B 0
                  mollicellin C 0
                  mollicellin E 0
                  mollicellin J 0
                  mollicellin K 0
                  mollicellin L 0
                  mollicellin M 0
                  nardoperoxide 0
                  neurolenin A 0
                  neurolenin B 0
                  neurolenin C 0
                  neurolenin D 0
                  norcaesalpinin D 0
                  norcaesalpinin E 0
                  norlichexanthone 0
                  nostocarboline 0
                  phomoxanthone A 0
                  phomoxanthone B 0
                  physalin B 0
                  physalin D 0
                  physalin F 0
                  physalin G 0
                  piperaquine 0
                  pracinostat 0
                  primaquine 0
                  proguanil 0
                  pyrimethamine 0
                  quercetin-7-O-[alpha-L-rhamnopyranosyl(1->6)-beta-D-galactopyranoside] 0
                  quinacrine + 0
                  quinidine + 0
                  quinine + 0
                  quinine sulfate + 0
                  quinine(1+) + 0
                  robustaside D 0
                  robustaside E 0
                  robustaside F 0
                  robustaside G 0
                  samaderine B 0
                  samaderine E 0
                  samaderine X 0
                  samaderine Z 0
                  scutianthraquinone A 0
                  scutianthraquinone B 0
                  scutianthraquinone C 0
                  simalikalactone D 0
                  sophoraflavanone G 0
                  sulfadoxine 0
                  tafenoquine 0
                  triacsin C 0
                  triclosan 0
                  venturamide A 0
                  venturamide B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 875
    role 855
      application 495
        pharmaceutical 436
          drug 436
            antiinfective agent 161
              antiparasitic agent 36
                antiprotozoal drug 27
                  antiplasmodial drug 19
                    antimalarial 19
                      (+)-(11R,2'S)-erythro-mefloquine + 0
                      (+)-artemisinin + 0
                      (-)-(11S,2'R)-erythro-mefloquine + 0
                      (R)-7-butyl-6,8-dihydroxy-3-[(3E)-pent-3-en-1-yl]-3,4-dihydroisochromen-1-one 0
                      2',4'-dihydroxy-3'-(2-hydroxy benzyl)-6'-methoxy chalcone 0
                      3,15-di-O-acetylbruceolide 0
                      3-(Z)-caffeoyllupeol 0
                      5,7,3'-trihydroxy-4',5'-(2'''',2''''-dimethylpyran)-8,2'-di(3-methyl-2-butenyl)-(2S)-flavanone 0
                      5-O-methylcelebixanthone 0
                      7-deacetylgedunin 0
                      8-azahypoxanthine 0
                      E64 0
                      Eunicea sesquiterpenoid 2 0
                      Eunicea sesquiterpenoid 3 0
                      WLL-vs 0
                      acedapsone 0
                      amburoside A 0
                      amodiaquine + 0
                      artemether 0
                      arterolane 0
                      arterolane maleate 0
                      artesunate 0
                      atovaquone 0
                      bauhinoxepin F 0
                      bauhinoxepin I 0
                      bauhinoxepin J 0
                      betulinic acid + 0
                      bidebiline C 0
                      bidebiline D 0
                      bielschowskysin 0
                      bipinnatone A 0
                      bipinnatone B 0
                      borrelidin 0
                      bromophycolide A 0
                      bruceolide + 0
                      caesalpinin C 0
                      caesalpinin D 0
                      caesalpinin F 0
                      callophycoic acid A 0
                      callophycoic acid B 0
                      callophycoic acid C 0
                      callophycoic acid D 0
                      callophycoic acid E 0
                      callophycoic acid F 0
                      callophycoic acid G 0
                      callophycoic acid H 0
                      callophycol A 0
                      callophycol B 0
                      caribenol A 0
                      caribenol B 0
                      caseargrewiin A 0
                      caseargrewiin B 0
                      caseargrewiin C 0
                      caseargrewiin D 0
                      cassiarin A 0
                      cassiarin B 0
                      celebixanthone + 0
                      chloroquine + 14
                      cochinchinone C 0
                      conessine 0
                      cordyheptapeptide A 0
                      cordyol C 0
                      crambescidin 800 0
                      cryptolepine 0
                      cycloguanil + 0
                      dapsone + 0
                      dehydroemetine 0
                      dihydroartemisinin 5
                      dioncopeltine A 0
                      dioncophylline A 0
                      dioncophylline C 0
                      diuvaretin 0
                      docetaxel anhydrous + 0
                      doxycycline + 1
                      dragomabin 0
                      dragonamide A 0
                      emetine + 0
                      emetine dihydrochloride + 0
                      emetine dihydrochloride hydrate 0
                      eurycomanone 0
                      exiguaflavanone A 0
                      exiguaflavanone B 0
                      gedunin + 0
                      gutolactone 0
                      hirsutellide A 0
                      hydroxychloroquine 0
                      isariotin F 0
                      isonordoperoxide 0
                      lactucin + 0
                      lactucopicrin 0
                      leachianone A 0
                      longirostrerone A 0
                      longirostrerone B 0
                      longirostrerone C 0
                      lumefantrine 0
                      lycorine 0
                      manzamine A + 0
                      mefloquine 0
                      methylene blue 0
                      minquartynoic acid 0
                      mollicellin B 0
                      mollicellin C 0
                      mollicellin E 0
                      mollicellin J 0
                      mollicellin K 0
                      mollicellin L 0
                      mollicellin M 0
                      nardoperoxide 0
                      neurolenin A 0
                      neurolenin B 0
                      neurolenin C 0
                      neurolenin D 0
                      norcaesalpinin D 0
                      norcaesalpinin E 0
                      norlichexanthone 0
                      nostocarboline 0
                      phomoxanthone A 0
                      phomoxanthone B 0
                      physalin B 0
                      physalin D 0
                      physalin F 0
                      physalin G 0
                      piperaquine 0
                      pracinostat 0
                      primaquine 0
                      proguanil 0
                      pyrimethamine 0
                      quercetin-7-O-[alpha-L-rhamnopyranosyl(1->6)-beta-D-galactopyranoside] 0
                      quinacrine + 0
                      quinidine + 0
                      quinine + 0
                      quinine sulfate + 0
                      quinine(1+) + 0
                      robustaside D 0
                      robustaside E 0
                      robustaside F 0
                      robustaside G 0
                      samaderine B 0
                      samaderine E 0
                      samaderine X 0
                      samaderine Z 0
                      scutianthraquinone A 0
                      scutianthraquinone B 0
                      scutianthraquinone C 0
                      simalikalactone D 0
                      sophoraflavanone G 0
                      sulfadoxine 0
                      tafenoquine 0
                      triacsin C 0
                      triclosan 0
                      venturamide A 0
                      venturamide B 0
paths to the root