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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:propazine
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Accession:CHEBI:38067 term browser browse the term
Definition:A diamino-1,3,5-triazine that is N,N'-di(propan-2-yl)-1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6.
Synonyms:exact_synonym: 6-chloro-N,N'-di(propan-2-yl)-1,3,5-triazine-2,4-diamine
 related_synonym: 2-Chloro-4,6-bis(isopropylamino)-1,3,5-triazine;   2-chloro-4,6-bis(isopropylamino)-s-triazine;   6-chloro-N,N'-(1-methylethyl)-[1,3,5]triazine-2,4-diamine;   6-chloro-N,N'-bis(1-methylethyl)-1,3,5-triazine-2,4-diamine;   6-chloro-N,N'-diisopropyl-1,3,5-triazine-2,4-diamine;   6-chloro-N,N'-diisopropyl-1,3,5-triazine-2,4-diyldiamine;   Formula=C9H16ClN5;   InChI=1S/C9H16ClN5/c1-5(2)11-8-13-7(10)14-9(15-8)12-6(3)4/h5-6H,1-4H3,(H2,11,12,13,14,15);   InChIKey=WJNRPILHGGKWCK-UHFFFAOYSA-N;   Prozinex;   SMILES=CC(C)Nc1nc(Cl)nc(NC(C)C)n1
 alt_id: CHEBI:26297;   CHEBI:34937
 xref: Beilstein:747081;   CAS:139-40-2;   KEGG:C14312;   LINCS:LSM-20981
 xref_mesh: MESH:C100043
 xref: PMID:16986790;   PMID:23875679;   PPDB:548;   Pesticides:propazine;   Reaxys:747081;   UM-BBD_compID:c0253


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propazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; propazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein; U 0126 inhibits the reaction [propazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein] CTD PMID:27431321 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
increases activity
increases expression
ISO formestane inhibits the reaction [propazine results in increased activity of CYP19A1 protein]
propazine results in increased expression of CYP19A1 mRNA
CTD PMID:10746939 PMID:11675267 NCBI chr 8:54,553,165...54,580,758 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein]; propazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein; U 0126 inhibits the reaction [propazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein] CTD PMID:27431321 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein]; propazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein; U 0126 inhibits the reaction [propazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein] CTD PMID:27431321 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of NOS2 protein]; U 0126 inhibits the reaction [propazine results in decreased expression of NOS2 protein] CTD PMID:27431321 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of NOS3 protein]; U 0126 inhibits the reaction [propazine results in decreased expression of NOS3 protein] CTD PMID:27431321 NCBI chr 4:10,793,834...10,814,170 JBrowse link
G Pde4a phosphodiesterase 4A decreases activity ISO propazine results in decreased activity of PDE4A protein CTD PMID:21251949 NCBI chr 8:19,706,649...19,751,937 JBrowse link
G Pde5a phosphodiesterase 5A affects activity ISO propazine affects the activity of PDE5 protein CTD PMID:21251949 NCBI chr 2:210,858,515...211,003,480 JBrowse link
G Pomc proopiomelanocortin increases secretion EXP propazine results in increased secretion of POMC protein modified form CTD PMID:19690231 NCBI chr 6:26,939,844...26,945,666 JBrowse link
G Rln1 relaxin 1 multiple interactions ISO propazine inhibits the reaction [RLN1 protein binds to RXFP1 protein] CTD PMID:27431321 NCBI chr 1:227,079,960...227,082,960 JBrowse link
G Rxfp1 relaxin family peptide receptor 1 decreases expression
multiple interactions
ISO propazine results in decreased expression of RXFP1 protein
propazine inhibits the reaction [RLN1 protein binds to RXFP1 protein]
CTD PMID:27431321 NCBI chr 2:164,772,270...164,893,484 JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 19762
    role 19708
      biological role 19708
        xenobiotic 18395
          propazine 11
Path 2
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  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    main group molecular entity 19651
                      s-block molecular entity 19418
                        hydrogen molecular entity 19413
                          hydrides 18746
                            inorganic hydride 17471
                              pnictogen hydride 17448
                                nitrogen hydride 17302
                                  azane 17009
                                    ammonia 17008
                                      organic amino compound 17007
                                        polyamine 8265
                                          diamine 8193
                                            diamino-1,3,5-triazine 3821
                                              propazine 11
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