Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:propazine
go back to main search page
Accession:CHEBI:38067 term browser browse the term
Definition:A diamino-1,3,5-triazine that is N,N'-di(propan-2-yl)-1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6.
Synonyms:exact_synonym: 6-chloro-N,N'-di(propan-2-yl)-1,3,5-triazine-2,4-diamine
 related_synonym: 2-Chloro-4,6-bis(isopropylamino)-1,3,5-triazine;   2-chloro-4,6-bis(isopropylamino)-s-triazine;   6-chloro-N,N'-(1-methylethyl)-[1,3,5]triazine-2,4-diamine;   6-chloro-N,N'-bis(1-methylethyl)-1,3,5-triazine-2,4-diamine;   6-chloro-N,N'-diisopropyl-1,3,5-triazine-2,4-diamine;   6-chloro-N,N'-diisopropyl-1,3,5-triazine-2,4-diyldiamine;   Formula=C9H16ClN5;   InChI=1S/C9H16ClN5/c1-5(2)11-8-13-7(10)14-9(15-8)12-6(3)4/h5-6H,1-4H3,(H2,11,12,13,14,15);   InChIKey=WJNRPILHGGKWCK-UHFFFAOYSA-N;   Prozinex;   SMILES=CC(C)Nc1nc(Cl)nc(NC(C)C)n1
 alt_id: CHEBI:26297;   CHEBI:34937
 xref: Beilstein:747081;   CAS:139-40-2;   KEGG:C14312;   LINCS:LSM-20981
 xref_mesh: MESH:C100043
 xref: PMID:16986790;   PMID:23875679;   PPDB:548;   Pesticides:propazine;   Reaxys:747081;   UM-BBD_compID:c0253



show annotations for term's descendants           Sort by:
 
propazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; propazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein; U 0126 inhibits the reaction [propazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein] CTD PMID:27431321 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity
ISO formestane inhibits the reaction [propazine results in increased activity of CYP19A1 protein]
propazine results in increased expression of CYP19A1 mRNA
CTD PMID:10746939 PMID:11675267 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein]; propazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein; U 0126 inhibits the reaction [propazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein] CTD PMID:27431321 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein]; propazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein; U 0126 inhibits the reaction [propazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein] CTD PMID:27431321 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of NOS2 protein]; U 0126 inhibits the reaction [propazine results in decreased expression of NOS2 protein] CTD PMID:27431321 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of NOS3 protein]; U 0126 inhibits the reaction [propazine results in decreased expression of NOS3 protein] CTD PMID:27431321 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Pde4a phosphodiesterase 4A decreases activity ISO propazine results in decreased activity of PDE4A protein CTD PMID:21251949 NCBI chr 8:19,706,649...19,751,937
Ensembl chr 8:19,703,290...19,751,961
JBrowse link
G Pde5a phosphodiesterase 5A affects activity ISO propazine affects the activity of PDE5 protein CTD PMID:21251949 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
JBrowse link
G Pomc proopiomelanocortin increases secretion EXP propazine results in increased secretion of POMC protein modified form CTD PMID:19690231 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Rln1 relaxin 1 multiple interactions ISO propazine inhibits the reaction [RLN1 protein binds to RXFP1 protein] CTD PMID:27431321 NCBI chr 1:227,079,960...227,082,960
Ensembl chr 1:227,079,966...227,082,882
JBrowse link
G Rxfp1 relaxin family peptide receptor 1 decreases expression
multiple interactions
ISO propazine results in decreased expression of RXFP1 protein
propazine inhibits the reaction [RLN1 protein binds to RXFP1 protein]
CTD PMID:27431321 NCBI chr 2:164,772,270...164,893,484
Ensembl chr 2:164,774,799...164,893,412
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20057
    role 20023
      biological role 20010
        xenobiotic 18687
          propazine 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 20057
    subatomic particle 20056
      composite particle 20068
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19971
                    main group molecular entity 19959
                      s-block molecular entity 19758
                        hydrogen molecular entity 19764
                          hydrides 19134
                            inorganic hydride 17935
                              pnictogen hydride 17901
                                nitrogen hydride 17789
                                  azane 17542
                                    ammonia 17541
                                      organic amino compound 17541
                                        polyamine 8326
                                          diamine 8255
                                            diamino-1,3,5-triazine 3834
                                              propazine 11
paths to the root