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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:38010 term browser browse the term
Definition:A member of the class of benzotriazines that is 1,2-dihydro-1,2,4-benzotriazine bearing a dimethylamino substitutent at position 3 and a methyl substituent at position 7 and in which the nitrogens at positions 1 and 2 are both acylated by a carboxy group of propylmalonic acid.
Synonyms:related_synonym: 1,2-Dihydro-3-dimethylamino-7-methyl-1,2-(propylmalonyl)-1,2,4-benzotriazine;   3-Dimethylamino-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine;   5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione;   Azapropazon;   Azapropazone;   Formula=C16H20N4O2;   InChI=1S/C16H20N4O2/c1-5-6-11-14(21)19-13-9-10(2)7-8-12(13)17-16(18(3)4)20(19)15(11)22/h7-9,11H,5-6H2,1-4H3;   InChIKey=MPHPHYZQRGLTBO-UHFFFAOYSA-N;   SMILES=CCCC1C(=O)N2N(C1=O)c1cc(C)ccc1N=C2N(C)C;   azapropazona;   azapropazonum
 xref: Beilstein:623763;   CAS:13539-59-8;   DrugBank:DB07402;   Drug_Central:266;   KEGG:D02966;   LINCS:LSM-5132
 xref_mesh: MESH:D001032
 xref: Patent:FR1440629;   Patent:US3349088;   Patent:US348024;   Reaxys:623763

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apazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Apazone results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
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  CHEBI ontology 19810
    role 19758
      application 19420
        anti-inflammatory agent 14959
          anti-inflammatory drug 13619
            non-steroidal anti-inflammatory drug 12703
              apazone 1
Path 2
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  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic heterocyclic compound 18425
                                  organic heteropolycyclic compound 17838
                                    organic heterobicyclic compound 16763
                                      mancude organic heterobicyclic parent 5202
                                        benzotriazine 13
                                          1,2,4-benzotriazine 7
                                            apazone 1
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