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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:38010 term browser browse the term
Definition:A member of the class of benzotriazines that is 1,2-dihydro-1,2,4-benzotriazine bearing a dimethylamino substitutent at position 3 and a methyl substituent at position 7 and in which the nitrogens at positions 1 and 2 are both acylated by a carboxy group of propylmalonic acid.
Synonyms:related_synonym: 1,2-Dihydro-3-dimethylamino-7-methyl-1,2-(propylmalonyl)-1,2,4-benzotriazine;   3-Dimethylamino-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine;   5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione;   Azapropazon;   Azapropazone;   Formula=C16H20N4O2;   InChI=1S/C16H20N4O2/c1-5-6-11-14(21)19-13-9-10(2)7-8-12(13)17-16(18(3)4)20(19)15(11)22/h7-9,11H,5-6H2,1-4H3;   InChIKey=MPHPHYZQRGLTBO-UHFFFAOYSA-N;   SMILES=CCCC1C(=O)N2N(C1=O)c1cc(C)ccc1N=C2N(C)C;   azapropazona;   azapropazonum
 xref: Beilstein:623763;   CAS:13539-59-8;   DrugBank:DB07402;   Drug_Central:266;   KEGG:D02966;   LINCS:LSM-5132
 xref_mesh: MESH:D001032
 xref: Patent:FR1440629;   Patent:US3349088;   Patent:US348024;   Reaxys:623763

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apazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Apazone results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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  CHEBI ontology 19800
    role 19751
      application 19498
        anti-inflammatory agent 15841
          anti-inflammatory drug 13634
            non-steroidal anti-inflammatory drug 12719
              apazone 1
Path 2
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  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organic heteropolycyclic compound 18043
                                    organic heterobicyclic compound 16859
                                      mancude organic heterobicyclic parent 5418
                                        benzotriazine 15
                                          1,2,4-benzotriazine 7
                                            apazone 1
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