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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:glycolithocholic acid
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Accession:CHEBI:37998 term browser browse the term
Definition:The glycine conjugate of lithocholic acid.
Synonyms:exact_synonym: N-(3alpha-hydroxy-5beta-cholan-24-oyl)glycine
 related_synonym: Formula=C26H43NO4;   Glycolithocholate;   InChI=1S/C26H43NO4/c1-16(4-9-23(29)27-15-24(30)31)20-7-8-21-19-6-5-17-14-18(28)10-12-25(17,2)22(19)11-13-26(20,21)3/h16-22,28H,4-15H2,1-3H3,(H,27,29)(H,30,31)/t16-,17-,18-,19+,20-,21+,22+,25+,26-/m1/s1;   InChIKey=XBSQTYHEGZTYJE-OETIFKLTSA-N;   Lithocholic acid glycine conjugate;   Lithocholylglycine;   N-((3-alpha,5-beta)-3-Hydroxy-24-oxocholan-24-yl)glycine;   SMILES=[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)CCC(=O)NCC(O)=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@@H](O)C2
 xref: Beilstein:3174407;   CAS:474-74-8;   KEGG:C15557
 xref_mesh: MESH:C027746
 cyclic_relationship: is_conjugate_acid_of CHEBI:60008


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glycolithocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases abundance ISO HSD11B1 gene mutant form results in decreased abundance of glycolithocholic acid CTD PMID:25061560 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Por cytochrome p450 oxidoreductase increases abundance ISO POR gene mutant form results in increased abundance of glycolithocholic acid CTD PMID:25034404 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
sulfoglycolithocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc10a1 solute carrier family 10 member 1 increases uptake ISO SLC10A1 protein results in increased uptake of sulfolithocholylglycine CTD PMID:29024779 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19817
    role 19767
      biological role 19767
        molecular messenger 18278
          neurotransmitter 10807
            glycine 1212
              glycine derivative 1201
                N-acylglycine 21
                  glycolithocholic acid 3
                    7-oxoglycolithocholic acid 0
                    sulfoglycolithocholic acid 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19817
    subatomic particle 19815
      composite particle 19815
        hadron 19815
          baryon 19815
            nucleon 19815
              atomic nucleus 19815
                atom 19815
                  main group element atom 19705
                    p-block element atom 19705
                      carbon group element atom 19614
                        carbon atom 19603
                          organic molecular entity 19603
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18435
                                    carbonyl compound 18435
                                      carboxylic acid 18113
                                        amino acid 14113
                                          alpha-amino acid 11599
                                            L-alpha-amino acid 11435
                                              serine family amino acid 2058
                                                glycine 1212
                                                  glycine derivative 1201
                                                    N-acylglycine 21
                                                      glycolithocholic acid 3
                                                        7-oxoglycolithocholic acid 0
                                                        sulfoglycolithocholic acid 1
paths to the root