CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: glycolithocholic acid
Accession: CHEBI:37998
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Definition: The glycine conjugate of lithocholic acid.
Synonyms: exact_synonym: N-(3alpha-hydroxy-5beta-cholan-24-oyl)glycine
related_synonym: Formula=C26H43NO4; Glycolithocholate; InChI=1S/C26H43NO4/c1-16(4-9-23(29)27-15-24(30)31)20-7-8-21-19-6-5-17-14-18(28)10-12-25(17,2)22(19)11-13-26(20,21)3/h16-22,28H,4-15H2,1-3H3,(H,27,29)(H,30,31)/t16-,17-,18-,19+,20-,21+,22+,25+,26-/m1/s1; InChIKey=XBSQTYHEGZTYJE-OETIFKLTSA-N; Lithocholic acid glycine conjugate; Lithocholylglycine; N-((3-alpha,5-beta)-3-Hydroxy-24-oxocholan-24-yl)glycine; SMILES=[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)CCC(=O)NCC(O)=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@@H](O)C2
xref: Beilstein:3174407; CAS:474-74-8; KEGG:C15557
xref_mesh: MESH:C027746
cyclic_relationship: is_conjugate_acid_of CHEBI:60008
G
Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
decreases abundance
ISO
HSD11B1 gene mutant form results in decreased abundance of glycolithocholic acid
CTD
PMID:25061560
NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
G
Por
cytochrome p450 oxidoreductase
increases abundance
ISO
POR gene mutant form results in increased abundance of glycolithocholic acid
CTD
PMID:25034404
NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
G
Slc10a1
solute carrier family 10 member 1
increases uptake
ISO
SLC10A1 protein results in increased uptake of sulfolithocholylglycine
CTD
PMID:29024779
NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
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