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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:17beta-hydroxy-17-methylestra-4,9,11-trien-3-one
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Accession:CHEBI:379896 term browser browse the term
Definition:A synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.
Synonyms:related_synonym: 17-beta-Hydroxy-17-methylestra-4,9,11-trien-3-one;   17-methyloestra-4,9,11-trien-3-one,17beta-ol;   17alpha-Methyltrienolone;   Formula=C19H24O2;   InChI=1S/C19H24O2/c1-18-9-7-15-14-6-4-13(20)11-12(14)3-5-16(15)17(18)8-10-19(18,2)21/h7,9,11,16-17,21H,3-6,8,10H2,1-2H3/t16-,17+,18+,19+/m1/s1;   InChIKey=CCCIJQPRIXGQOE-XWSJACJDSA-N;   Methyltrienolone;   R1881;   R1881 (synthetic androgen);   SMILES=[H][C@@]12CCC3=CC(=O)CCC3=C1C=C[C@@]1(C)[C@@]2([H])CC[C@]1(C)O;   metribolona;   metribolone;   metribolonum
 alt_id: CHEBI:45313;   CHEBI:59645
 xref: Beilstein:2626053;   CAS:965-93-5;   DrugBank:DB02998;   KEGG:C14257
 xref_mesh: MESH:D015741
 xref: PDBeChem:R18;   PMID:17077481;   Patent:NL6401555


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17beta-hydroxy-17-methylestra-4,9,11-trien-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases expression ISO Metribolone results in increased expression of ABCC4 mRNA CTD PMID:17010675 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Acadsb acyl-CoA dehydrogenase, short/branched chain decreases expression ISO Metribolone results in decreased expression of ACADSB protein CTD PMID:17152098 NCBI chr 1:201,981,362...202,022,771
Ensembl chr 1:201,981,357...202,021,008
JBrowse link
G Acp3 acid phosphatase 3 increases expression ISO Metribolone results in increased expression of ACP3 protein CTD PMID:17541959 NCBI chr 8:112,838,574...112,884,062
Ensembl chr 8:112,834,707...112,884,077
JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 multiple interactions
increases expression
ISO Metribolone promotes the reaction [NDRG1 protein binds to ACSL3 protein]
Metribolone results in increased expression of ACSL3 mRNA
CTD PMID:16751804 PMID:17010675 PMID:17220478 NCBI chr 9:84,569,601...84,593,565
Ensembl chr 9:84,569,597...84,593,565
JBrowse link
G Actb actin, beta multiple interactions
increases expression
ISO Metribolone promotes the reaction [NDRG1 protein binds to ACTB protein]
Metribolone results in increased expression of ACTB protein
CTD PMID:17152098 PMID:17220478 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Actg1 actin, gamma 1 increases expression ISO Metribolone results in increased expression of ACTG1 protein CTD PMID:17152098 NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954
Ensembl chr10:75,643,054...75,644,954
JBrowse link
G Adam7 ADAM metallopeptidase domain 7 increases expression ISO Metribolone results in increased expression of ADAM7 mRNA CTD PMID:17010675 NCBI chr15:49,418,946...49,467,174
Ensembl chr15:49,418,946...49,467,174
JBrowse link
G Aida axin interactor, dorsalization associated increases expression ISO Metribolone results in increased expression of AIDA mRNA CTD PMID:17010196 NCBI chr13:101,698,096...101,724,928
Ensembl chr13:101,698,096...101,724,923
JBrowse link
G Aip aryl-hydrocarbon receptor-interacting protein decreases expression ISO Metribolone results in decreased expression of AIP protein CTD PMID:17152098 NCBI chr 1:219,361,859...219,373,924
Ensembl chr 1:219,361,860...219,374,014
JBrowse link
G Akip1 A-kinase interacting protein 1 increases expression ISO Metribolone results in increased expression of AKIP1 mRNA CTD PMID:17010196 NCBI chr 1:174,330,628...174,339,494
Ensembl chr 1:174,330,695...174,339,494
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 increases expression ISO Metribolone results in increased expression of AKR1A1 protein CTD PMID:17152098 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO bicalutamide inhibits the reaction [Metribolone results in increased phosphorylation of AKT1 protein]; Hydrogen Peroxide promotes the reaction [Metribolone results in increased phosphorylation of AKT1 protein] CTD PMID:17325745 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 increases expression ISO Metribolone results in increased expression of ALDH1A3 mRNA CTD PMID:17526768 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Aldh9a1 aldehyde dehydrogenase 9 family, member A1 increases expression ISO Metribolone results in increased expression of ALDH9A1 protein CTD PMID:17152098 NCBI chr13:85,580,828...85,597,497
Ensembl chr13:85,580,828...85,597,493
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression ISO Metribolone results in increased expression of ALDOA mRNA CTD PMID:17010196 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Amh anti-Mullerian hormone multiple interactions ISO AMH protein inhibits the reaction [Metribolone results in increased expression of KLK3 mRNA] CTD PMID:16740653 NCBI chr 7:11,775,155...11,777,503
Ensembl chr 7:11,775,155...11,777,503
JBrowse link
G Anxa4 annexin A4 increases expression ISO Metribolone results in increased expression of ANXA4 protein CTD PMID:17152098 NCBI chr 4:118,538,775...118,595,591
Ensembl chr 4:118,538,777...118,595,580
JBrowse link
G Ap1m2 adaptor related protein complex 1 subunit mu 2 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to AP1M2 protein] CTD PMID:17220478 NCBI chr 8:22,318,941...22,336,827
Ensembl chr 8:22,319,331...22,336,794
JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to AP2M1 protein] CTD PMID:17220478 NCBI chr11:84,041,184...84,047,542
Ensembl chr11:84,041,184...84,047,546
JBrowse link
G Apmap adipocyte plasma membrane associated protein increases expression ISO Metribolone results in increased expression of APMAP protein CTD PMID:17152098 NCBI chr 3:146,376,828...146,407,259
Ensembl chr 3:146,376,828...146,407,252
JBrowse link
G Appbp2 amyloid beta precursor protein binding protein 2 increases expression ISO Metribolone results in increased expression of APPBP2 mRNA CTD PMID:16751804 NCBI chr10:72,503,347...72,545,141
Ensembl chr10:72,503,347...72,545,141
JBrowse link
G Ar androgen receptor decreases expression
affects binding
multiple interactions
affects localization
increases expression
increases activity
ISO
EXP
Metribolone results in decreased expression of AR mRNA; Metribolone results in decreased expression of AR mRNA mutant form
Metribolone binds to AR protein; Metribolone binds to AR protein mutant form
1,2,3,6,7,8-hexachlorodibenzodioxin inhibits the reaction [Metribolone results in increased activity of AR protein]; 1-acetonaphthone inhibits the reaction [Metribolone results in increased activity of AR protein]; 1-aminopyrene inhibits the reaction [Metribolone results in increased activity of AR protein]; 1-hydroxypyrene inhibits the reaction [Metribolone results in increased activity of AR protein]; 1-nitropyrene inhibits the reaction [Metribolone results in increased activity of AR protein]; 16 alpha,17-epoxyprogesterone inhibits the reaction [Metribolone results in increased activity of AR protein]; 17 alpha,20 beta-dihydroxypregn-4-en-3-one inhibits the reaction [Metribolone results in increased activity of AR protein]; 17-(5'-isoxazolyl)androsta-4,16-dien-3-one inhibits the reaction [Metribolone binds to AR protein]; 2,2',3',4,4',5-hexachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,2',4,5'-tetrabromodiphenyl ether inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,2',4,5'-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,2'-biphenol inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,2'-dichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; 2,2-di(4-methacryloxyphenyl)propane inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3',4,4',5-pentachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3',4,4'-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,3',4,4'-pentachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,4',6-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,4,4'5-pentachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,4,5,6-pentachloroaniline inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,4,7,8-pentachlorodibenzofuran inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,5,6-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,5,6-tetrachlorohydroquinone inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3-dichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,4'-dichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,4,4',5-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,4,4'-trichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,4,6-trichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,5,3'-trichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,6-di-tert-butyl-4-hydroxymethylphenol inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,6-dichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2-aminodiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2-anthramine inhibits the reaction [Metribolone results in increased activity of AR protein]; 2-chlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2-tert-butylhydroquinone inhibits the reaction [Metribolone results in increased activity of AR protein]; 20-hydroximino-4,16-pregnadien-3-one inhibits the reaction [Metribolone binds to AR protein]; 3,3'-Dichlorobenzidine inhibits the reaction [Metribolone results in increased activity of AR protein]; 3,3'-dichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 3,5-dichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 4,16-androstadien-3-one analog inhibits the reaction [Metribolone binds to AR protein]; 4-benzylpyridine inhibits the reaction [Metribolone results in increased activity of AR protein]; 4-methylbenzenethiol inhibits the reaction [Metribolone results in increased activity of AR protein]; 4-phenylphenol inhibits the reaction [Metribolone binds to AR protein]; 4-tert-octylphenol inhibits the reaction [Metribolone results in increased activity of AR protein]; 6-(3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)pyridine-2-sulfonic acid amide inhibits the reaction [Metribolone affects the localization of AR protein]; 9,10-Dimethyl-1,2-benzanthracene inhibits the reaction [Metribolone results in increased activity of AR protein]; 9,10-dimethylanthracene inhibits the reaction [Metribolone results in increased activity of AR protein]; 9-methylanthracene inhibits the reaction [Metribolone results in increased activity of AR protein]; [4,4'-hexafluorisopropylidene diphenol binds to and results in decreased activity of AR protein] inhibits the reaction [Metribolone binds to AR protein]; [4,4'-hexafluorisopropylidene diphenol binds to and results in decreased activity of AR protein] which results in decreased susceptibility to Metribolone; [bisphenol A binds to and results in decreased activity of AR protein] inhibits the reaction [Metribolone binds to AR protein]; [bisphenol A binds to and results in decreased activity of AR protein] which results in decreased susceptibility to Metribolone; [iprodione binds to and results in decreased activity of AR protein] inhibits the reaction [Metribolone binds to AR protein]; [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to CNOT1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to EP300 protein modified form]; [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to HELZ2 protein modified form]; [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOA3 protein modified form]; [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOR1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NR0B2 protein modified form]; [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to TRERF1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to CHD9 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to DHX30 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to GNAQ protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to HR protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to ITGB3BP protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to KAT2B protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MEN1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MGMT protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NCOR2 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NELFB protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NFKBIB protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NRIP1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PELP1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PIAS2 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PPRC1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PRAME protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TGFB1I1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TRIM24 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TRRAP protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to ZNHIT3 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to AR protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to BRD8 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CREBBP protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to GSN protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to JMJD1C protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to LCOR protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MED1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA2 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA6 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NR0B1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PPARGC1A protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PRDM2 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to RBL2 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to RELA protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to SLC30A9 protein modified form]; [Metribolone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein; [vinclozolin binds to and results in decreased activity of AR protein] inhibits the reaction [Metribolone binds to AR protein]; Acriflavine inhibits the reaction [Metribolone results in increased activity of AR protein]; alachlor inhibits the reaction [Metribolone results in increased activity of AR protein]; alpha,alpha-dimethoxytoluene inhibits the reaction [Metribolone results in increased activity of AR protein]; alpha-hexachlorocyclohexane inhibits the reaction [Metribolone results in increased activity of AR protein]; androsta-5,16-dien-3 beta-ol analog inhibits the reaction [Metribolone binds to AR protein]; anthracene inhibits the reaction [Metribolone results in increased activity of AR protein]; AR mRNA affects the reaction [Metribolone results in increased expression of ARG1 protein]; AR mRNA affects the reaction [Metribolone results in increased expression of ARG2 protein]; AR mRNA affects the reaction [Metribolone results in increased secretion of CXCL8 protein]; AR protein affects the reaction [Metribolone results in decreased expression of MIR204 mRNA]; AR protein affects the reaction [Metribolone results in decreased expression of SESN1 protein]; AR protein affects the reaction [Metribolone results in increased abundance of Reactive Oxygen Species]; AR protein promotes the reaction [Metribolone results in increased expression of ATP7B mRNA]; AR protein promotes the reaction [Metribolone results in increased expression of SLC31A1 mRNA]; AR protein promotes the reaction [Metribolone results in increased expression of SLC31A1 protein]; AR protein promotes the reaction [Metribolone results in increased expression of STEAP4 mRNA]; Arsenic Trioxide inhibits the reaction [Metribolone promotes the reaction [AR protein binds to KLK3 promoter]]; Benzhydryl Compounds inhibits the reaction [Metribolone results in increased activity of AR protein]; Benzo(a)pyrene inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Benzo(a)pyrene inhibits the reaction [Metribolone results in increased activity of AR protein]; Benzo(a)pyrene metabolite inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; benzo(j)fluoranthene inhibits the reaction [Metribolone results in increased activity of AR protein]; benzo(k)fluoranthene inhibits the reaction [Metribolone results in increased activity of AR protein]; Benzophenones inhibits the reaction [Metribolone results in increased activity of AR protein]; bicalutamide inhibits the reaction [[Metribolone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]; bicalutamide inhibits the reaction [Metribolone results in increased activity of AR protein mutant form]; bicalutamide inhibits the reaction [Metribolone results in increased activity of AR protein]; bicalutamide inhibits the reaction [Metribolone results in increased folding of and results in increased stability of AR protein]; bifenox inhibits the reaction [Metribolone results in increased activity of AR protein]; bisphenol A inhibits the reaction [Metribolone results in increased activity of AR protein]; bitertanol inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Bortezomib inhibits the reaction [Metribolone results in increased activity of AR protein]; Budesonide inhibits the reaction [Metribolone results in increased activity of AR protein]; Busulfan inhibits the reaction [Metribolone results in increased activity of AR protein]; Cadmium Chloride inhibits the reaction [Metribolone binds to AR protein]; carfilzomib inhibits the reaction [Metribolone results in increased activity of AR protein]; CH 5166623 inhibits the reaction [Metribolone affects the localization of AR protein]; CH4933468 inhibits the reaction [Metribolone affects the localization of AR protein]; chlorobenzilate inhibits the reaction [Metribolone results in increased activity of AR protein]; chlorocresol inhibits the reaction [Metribolone results in increased activity of AR protein]; chrysene inhibits the reaction [Metribolone results in increased activity of AR protein]; Colforsin promotes the reaction [Metribolone results in increased activity of AR protein]; corticosterone acetate inhibits the reaction [Metribolone results in increased activity of AR protein]; Corticosterone inhibits the reaction [Metribolone results in increased activity of AR protein]; Cosmetics inhibits the reaction [Metribolone results in increased activity of AR protein]; Cyclohexylamines inhibits the reaction [Metribolone results in increased activity of AR protein]; Cyclopentanes inhibits the reaction [Metribolone results in increased activity of AR protein]; cypermethrin inhibits the reaction [Metribolone results in increased activity of AR protein]; Cyproterone Acetate inhibits the reaction [[Metribolone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]; Cyproterone Acetate inhibits the reaction [Metribolone results in increased activity of AR protein]; Cyproterone Acetate promotes the reaction [Metribolone results in increased expression of AR mRNA]; DDT inhibits the reaction [Metribolone affects the localization of AR protein]; DDT inhibits the reaction [Metribolone promotes the reaction [AR protein binds to KLK3 promoter]]; DDT inhibits the reaction [Metribolone results in increased expression of AR protein]; Deanol inhibits the reaction [Metribolone results in increased activity of AR protein]; Dexamethasone inhibits the reaction [Metribolone results in increased activity of AR protein]; diallyl trisulfide inhibits the reaction [Metribolone affects the localization of AR protein]; Dianisidine inhibits the reaction [Metribolone results in increased activity of AR protein]; dichlone inhibits the reaction [Metribolone results in increased activity of AR protein]; Dichlorodiphenyl Dichloroethylene analog inhibits the reaction [Metribolone results in increased activity of AR protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone affects the localization of AR protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone promotes the reaction [AR protein binds to KLK3 promoter]]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone results in increased activity of AR protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone results in increased expression of AR protein]; Dichlorvos promotes the reaction [Metribolone results in increased activity of AR protein]; dichlozolinate inhibits the reaction [Metribolone results in increased activity of AR protein]; Dicofol inhibits the reaction [Metribolone results in increased activity of AR protein]; Dieldrin inhibits the reaction [Metribolone results in increased activity of AR protein]; Diethylstilbestrol inhibits the reaction [Metribolone results in increased activity of AR protein]; Diuron inhibits the reaction [Metribolone results in increased activity of AR protein]; Endosulfan inhibits the reaction [Metribolone results in increased activity of AR protein]; enilconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; enzacamene inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; epoxiconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; Estradiol inhibits the reaction [Metribolone results in increased activity of AR protein]; Estriol inhibits the reaction [Metribolone results in increased activity of AR protein]; Ethinyl Estradiol inhibits the reaction [Metribolone results in increased activity of AR protein]; Etoposide inhibits the reaction [Metribolone results in increased activity of AR protein]; fenarimol inhibits the reaction [Metribolone results in increased activity of AR protein]; Fenitrothion inhibits the reaction [Metribolone results in increased activity of AR protein]; Fenthion inhibits the reaction [Metribolone results in increased activity of AR protein]; Finasteride inhibits the reaction [Metribolone results in increased activity of AR protein]; fisetin inhibits the reaction [Metribolone results in increased folding of and results in increased stability of AR protein]; Flame Retardants inhibits the reaction [Metribolone results in increased activity of AR protein]; fluoranthene inhibits the reaction [Metribolone results in increased activity of AR protein]; fluoxastrobin inhibits the reaction [Metribolone results in increased activity of AR protein]; Flutamide inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Flutamide inhibits the reaction [Metribolone binds to AR protein]; Food Additives inhibits the reaction [Metribolone results in increased activity of AR protein]; galaxolide inhibits the reaction [Metribolone results in increased activity of AR protein]; gamma-Linolenic Acid inhibits the reaction [Metribolone results in increased activity of AR protein]; Hexylresorcinol inhibits the reaction [Metribolone results in increased activity of AR protein]; homosalate inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; homosalate inhibits the reaction [Metribolone results in increased activity of AR protein]; Hydrocarbons, Chlorinated inhibits the reaction [Metribolone results in increased activity of AR protein]; hydroxyflutamide inhibits the reaction [Metribolone results in increased activity of AR protein]; IL6 protein inhibits the reaction [Metribolone results in increased activity of AR protein]; Ketoconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; Linuron inhibits the reaction [Metribolone binds to AR protein]; Linuron inhibits the reaction [Metribolone results in increased activity of AR protein]; mancozeb inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; meprednisone inhibits the reaction [Metribolone results in increased activity of AR protein]; Methiocarb inhibits the reaction [Metribolone results in increased activity of AR protein]; methoxyacetic acid promotes the reaction [Metribolone results in increased activity of AR protein]; Methoxychlor inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Methoxychlor inhibits the reaction [Metribolone results in increased activity of AR protein]; Methoxychlor metabolite inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Methyl Parathion inhibits the reaction [Metribolone results in increased activity of AR protein]; metoprine inhibits the reaction [Metribolone results in increased activity of AR protein]; Metribolone binds to and affects the folding of AR protein; Metribolone binds to and results in increased activity of AR protein; Metribolone inhibits the reaction [CREBBP protein results in increased activity of AR protein]; Metribolone inhibits the reaction [NCOA1 protein results in increased activity of AR protein]; Metribolone inhibits the reaction [NCOA3 protein results in increased activity of AR protein]; Metribolone promotes the reaction [AR protein binds to ATR promoter]; Metribolone promotes the reaction [AR protein binds to CLU enhancer]; Metribolone promotes the reaction [AR protein binds to GSTE1 promoter]; Metribolone promotes the reaction [AR protein binds to IGFBP3 promoter]; Metribolone promotes the reaction [AR protein binds to KLK3 enhancer]; Metribolone promotes the reaction [AR protein binds to KLK3 promoter]; Metribolone promotes the reaction [AR protein binds to NKX3-1 enhancer]; Metribolone promotes the reaction [AR protein binds to NKX3-1 promoter]; Metribolone results in increased folding of and results in increased stability of AR protein; Metribolone results in increased localization of and results in increased activity of AR protein; Mifepristone inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Mifepristone inhibits the reaction [Metribolone results in increased activity of AR protein mutant form]; Mifepristone inhibits the reaction [Metribolone results in increased activity of AR protein]; nilutamide inhibits the reaction [Metribolone results in increased activity of AR protein]; Nitrobenzenes inhibits the reaction [Metribolone results in increased activity of AR protein]; nitrofen inhibits the reaction [Metribolone results in increased activity of AR protein]; nonylphenol inhibits the reaction [Metribolone results in increased activity of AR protein]; nootkatone inhibits the reaction [Metribolone results in increased activity of AR protein]; o,p'-DDT inhibits the reaction [Metribolone results in increased activity of AR protein]; PA2G4 protein inhibits the reaction [Cyproterone Acetate promotes the reaction [Metribolone results in increased expression of AR mRNA]]; PA2G4 protein inhibits the reaction [Metribolone results in increased expression of AR mRNA]; pentabrominated diphenyl ether 100 inhibits the reaction [Metribolone results in increased activity of AR protein]; Pesticides inhibits the reaction [Metribolone results in increased activity of AR protein]; Plasticizers inhibits the reaction [Metribolone results in increased activity of AR protein]; Pregnadienes analog inhibits the reaction [Metribolone binds to AR protein]; prochloraz inhibits the reaction [Metribolone results in increased activity of AR protein]; procymidone inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; procymidone inhibits the reaction [Metribolone binds to AR protein]; procymidone inhibits the reaction [Metribolone results in increased activity of AR protein]; Proflavine inhibits the reaction [Metribolone results in increased activity of AR protein]; Progesterone inhibits the reaction [Metribolone results in increased activity of AR protein]; propiconazole inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; propiconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; pyrene inhibits the reaction [Metribolone results in increased activity of AR protein]; pyridaben inhibits the reaction [Metribolone results in increased activity of AR protein]; retene inhibits the reaction [Metribolone results in increased activity of AR protein]; ronnel inhibits the reaction [Metribolone results in increased activity of AR protein]; Spironolactone inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Spironolactone inhibits the reaction [Metribolone results in increased activity of AR protein]; ST 1481 inhibits the reaction [Metribolone results in increased activity of AR protein]; tebuconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; tetrabromobisphenol A inhibits the reaction [Metribolone results in increased activity of AR protein]; Topotecan inhibits the reaction [Metribolone results in increased activity of AR protein]; Toxaphene inhibits the reaction [Metribolone results in increased activity of AR protein]; Trenbolone Acetate inhibits the reaction [Metribolone results in increased activity of AR protein]; triadimefon inhibits the reaction [Metribolone results in increased activity of AR protein]; Triclosan inhibits the reaction [Metribolone results in increased activity of AR protein]; trifloxystrobin inhibits the reaction [Metribolone results in increased activity of AR protein]; tris(1,3-dichloro-2-propyl)phosphate affects the reaction [Metribolone affects the localization of AR protein]; tris(1,3-dichloro-2-propyl)phosphate inhibits the reaction [Metribolone results in increased expression of AR protein]; trityl chloride inhibits the reaction [Metribolone results in increased activity of AR protein]; Vehicle Emissions analog inhibits the reaction [Metribolone binds to AR protein]; vinclozolin inhibits the reaction [Metribolone results in increased activity of AR protein]; vinclozolin metabolite inhibits the reaction [Metribolone results in increased activity of AR protein]; Zearalenone inhibits the reaction [Metribolone results in increased activity of AR protein]
AR protein promotes the reaction [Metribolone results in increased expression of FSHB mRNA]
1-methylphenanthrene inhibits the reaction [Metribolone binds to AR protein]; 1-naphthaldehyde inhibits the reaction [Metribolone binds to AR protein]; 1-naphthol inhibits the reaction [Metribolone binds to AR protein]; 10,11-dihydro-5H-dibenzo(a,d)cycloheptene analog inhibits the reaction [Metribolone binds to AR protein]; 10,11-dihydro-5H-dibenzo(a,d)cycloheptene inhibits the reaction [Metribolone binds to AR protein]; 2,2',4,4',5-brominated diphenyl ether inhibits the reaction [Metribolone binds to AR protein]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Metribolone binds to AR protein]; 2-methylphenanthrene inhibits the reaction [Metribolone binds to AR protein]; 2-naphthol inhibits the reaction [Metribolone binds to AR protein]; 9-phenanthrol inhibits the reaction [Metribolone binds to AR protein]; Anthracenes analog inhibits the reaction [Metribolone binds to AR protein]; benzaldehyde inhibits the reaction [Metribolone binds to AR protein]; Biphenyl Compounds analog inhibits the reaction [Metribolone binds to AR protein]; decamethrin inhibits the reaction [Metribolone results in increased expression of AR mRNA]; Dihydrotestosterone inhibits the reaction [Metribolone binds to AR protein]; Flame Retardants inhibits the reaction [Metribolone binds to AR protein]; hexabromodiphenyl ether 154 inhibits the reaction [Metribolone binds to AR protein]; hydroxyflutamide inhibits the reaction [Metribolone binds to AR protein]; Linuron inhibits the reaction [Metribolone binds to AR protein]; Methiocarb inhibits the reaction [Metribolone results in increased expression of AR mRNA]; naphthalene inhibits the reaction [Metribolone binds to AR protein]; Naphthols analog inhibits the reaction [Metribolone binds to AR protein]; pentabrominated diphenyl ether 100 inhibits the reaction [Metribolone binds to AR protein]; pentabromodiphenyl ether inhibits the reaction [Metribolone binds to AR protein]; phenanthrene analog inhibits the reaction [Metribolone binds to AR protein]; phenanthrene inhibits the reaction [Metribolone binds to AR protein]; Phenols analog inhibits the reaction [Metribolone binds to AR protein]; prochloraz inhibits the reaction [Metribolone binds to AR protein]; prochloraz inhibits the reaction [Metribolone results in increased expression of AR mRNA]; Tetrahydronaphthalenes inhibits the reaction [Metribolone binds to AR protein]
Metribolone results in increased expression of AR mRNA; Metribolone results in increased expression of AR protein
Metribolone results in increased activity of AR protein; Metribolone results in increased activity of AR protein mutant form
CTD PMID:3695475 PMID:10053169 PMID:10188193 PMID:10771140 PMID:10910998 PMID:11118046 PMID:11751618 PMID:11956172 PMID:11981028 PMID:12032296 PMID:12114440 PMID:12161000 PMID:12711008 PMID:12730620 PMID:14565775 PMID:15084347 PMID:15103026 PMID:15336702 PMID:15519604 PMID:15589981 PMID:15597887 PMID:15673607 PMID:15950459 PMID:15994225 PMID:16005038 PMID:16302272 PMID:16603237 PMID:16675544 PMID:16751804 PMID:16825320 PMID:16916032 PMID:17148459 PMID:17219378 PMID:17325745 PMID:17541959 PMID:18324785 PMID:18922931 PMID:19131511 PMID:19318562 PMID:19564212 PMID:19622577 PMID:20711410 PMID:21134073 PMID:21308717 PMID:23146716 PMID:23562765 PMID:23704919 PMID:23871939 PMID:24004914 PMID:25320179 PMID:25682698 PMID:25797256 PMID:26485406 PMID:26709203 PMID:26867867 PMID:28751236 PMID:29427707 PMID:30818834 PMID:30951782 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arcn1 archain 1 increases expression ISO Metribolone results in increased expression of ARCN1 protein CTD PMID:17152098 NCBI chr 8:49,051,257...49,075,861
Ensembl chr 8:49,051,246...49,075,892
JBrowse link
G Arg1 arginase 1 multiple interactions
increases expression
ISO AR mRNA affects the reaction [Metribolone results in increased expression of ARG1 protein]; CXCL8 mRNA affects the reaction [Metribolone results in increased expression of ARG1 protein] CTD PMID:20711410 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Arg2 arginase 2 multiple interactions
increases expression
ISO AR mRNA affects the reaction [Metribolone results in increased expression of ARG2 protein]; CXCL8 mRNA affects the reaction [Metribolone results in increased expression of ARG2 protein]
Metribolone results in increased expression of ARG2 mRNA; Metribolone results in increased expression of ARG2 protein
CTD PMID:20711410 NCBI chr 6:102,311,097...102,338,406
Ensembl chr 6:102,311,116...102,338,520
JBrowse link
G Arhgap1 Rho GTPase activating protein 1 increases expression ISO Metribolone results in increased expression of ARHGAP1 protein CTD PMID:17152098 NCBI chr 3:80,555,196...80,576,881
Ensembl chr 3:80,555,196...80,576,856
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO Metribolone results in decreased expression of ASNS protein CTD PMID:17152098 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Metribolone results in increased expression of ATF3 protein CTD PMID:16516039 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions
increases phosphorylation
ISO [ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]] which results in increased expression of ERG mRNA; ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]
Metribolone results in increased phosphorylation of ATM protein
CTD PMID:23272087 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to ATP1A1 protein] CTD PMID:17220478 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023
JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions
increases expression
ISO AR protein promotes the reaction [Metribolone results in increased expression of ATP7B mRNA] CTD PMID:25320179 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Atr ATR serine/threonine kinase multiple interactions
increases phosphorylation
increases expression
ISO ATR mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]; Metribolone promotes the reaction [AR protein binds to ATR promoter]; Metribolone promotes the reaction [UXT protein binds to ATR promoter]
Metribolone results in increased phosphorylation of ATR protein
Metribolone results in increased expression of ATR mRNA
CTD PMID:19318562 PMID:23272087 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G Atxn3 ataxin 3 increases expression ISO Metribolone results in increased expression of ATXN3 mRNA CTD PMID:16751804 NCBI chr 6:125,817,420...125,853,461
Ensembl chr 6:125,819,640...125,853,461
JBrowse link
G B2m beta-2 microglobulin increases expression
multiple interactions
ISO Metribolone results in increased expression of B2M mRNA
Metribolone results in increased expression of and results in increased secretion of B2M protein; resveratrol inhibits the reaction [Metribolone results in increased expression of B2M mRNA]
CTD PMID:17131305 PMID:17404077 PMID:18586690 NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309
JBrowse link
G Bcas1 brain enriched myelin associated protein 1 increases expression ISO Metribolone results in increased expression of BCAS1 mRNA CTD PMID:17010196 NCBI chr 3:167,957,994...168,033,462
Ensembl chr 3:167,957,994...168,033,457
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO Metribolone results in increased expression of BGLAP mRNA CTD PMID:19759027 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Blcap BLCAP, apoptosis inducing factor increases expression ISO Metribolone results in increased expression of BLCAP mRNA CTD PMID:17010196 NCBI chr 3:154,040,165...154,042,096
Ensembl chr 3:154,040,166...154,042,099
JBrowse link
G Blvra biliverdin reductase A increases expression ISO Metribolone results in increased expression of BLVRA protein CTD PMID:17152098 NCBI chr 3:119,552,550...119,577,796
Ensembl chr 3:119,561,290...119,577,806
JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression ISO Metribolone results in increased expression of BRCA1 mRNA CTD PMID:17010196 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Brca2 BRCA2, DNA repair associated increases expression ISO Metribolone results in increased expression of BRCA2 mRNA CTD PMID:17010196 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
G Brd8 bromodomain containing 8 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to BRD8 protein modified form] CTD PMID:28751236 NCBI chr18:27,375,645...27,423,989
Ensembl chr18:27,398,688...27,424,090
JBrowse link
G Bri3 brain protein I3 affects splicing ISO Metribolone affects the splicing of BRI3 mRNA CTD PMID:17010196 NCBI chr12:12,322,247...12,330,929
Ensembl chr12:12,322,243...12,330,939
JBrowse link
G Brip1 BRCA1 interacting protein C-terminal helicase 1 increases expression
multiple interactions
ISO Metribolone results in increased expression of BRIP1 mRNA
UXT protein affects the reaction [Metribolone results in increased expression of BRIP1 mRNA]
CTD PMID:19318562 NCBI chr10:73,507,009...73,632,742
Ensembl chr10:73,507,100...73,629,581
JBrowse link
G Brms1 BRMS1, transcriptional repressor and anoikis regulator increases expression ISO Metribolone results in increased expression of BRMS1 mRNA CTD PMID:17010196 NCBI chr 1:220,325,352...220,334,616 JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase increases expression ISO Metribolone results in increased expression of BUB1 mRNA CTD PMID:19318562 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 increases expression ISO Metribolone results in increased expression of CAMKK2 mRNA CTD PMID:16751804 NCBI chr12:39,253,409...39,302,601
Ensembl chr12:39,253,409...39,302,601
JBrowse link
G Canx calnexin multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to CANX protein] CTD PMID:17220478 NCBI chr10:35,800,942...35,833,939
Ensembl chr10:35,800,942...35,833,861
JBrowse link
G Capza1 capping actin protein of muscle Z-line subunit alpha 1 increases expression ISO Metribolone results in increased expression of CAPZA1 protein CTD PMID:17152098 NCBI chr 2:207,305,748...207,350,812
Ensembl chr 2:207,305,752...207,350,812
JBrowse link
G Capzb capping actin protein of muscle Z-line subunit beta increases expression ISO Metribolone results in increased expression of CAPZB protein CTD PMID:17152098 NCBI chr 5:157,642,742...157,742,487
Ensembl chr 5:157,642,751...157,742,478
JBrowse link
G Casc3 CASC3 exon junction complex subunit increases expression ISO Metribolone results in increased expression of CASC3 mRNA CTD PMID:17010196 NCBI chr10:86,724,534...86,744,485
Ensembl chr10:86,724,427...86,745,927
JBrowse link
G Cbl Cbl proto-oncogene increases expression ISO Metribolone results in increased expression of CBL mRNA CTD PMID:16301331 NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722
JBrowse link
G Ccna2 cyclin A2 increases expression ISO Metribolone results in increased expression of CCNA2 mRNA CTD PMID:19318562 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Cd200 Cd200 molecule decreases expression ISO Metribolone results in decreased expression of CD200 mRNA CTD PMID:17010675 NCBI chr11:60,371,617...60,398,450
Ensembl chr11:60,371,684...60,403,196
JBrowse link
G Cdc6 cell division cycle 6 increases expression ISO Metribolone results in increased expression of CDC6 mRNA CTD PMID:19318562 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Cdh1 cadherin 1 affects localization ISO Metribolone affects the localization of CDH1 protein CTD PMID:17440980 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdk2ap1 cyclin-dependent kinase 2 associated protein 1 increases expression ISO Metribolone results in increased expression of CDK2AP1 mRNA CTD PMID:17010196 NCBI chr12:37,668,369...37,677,067
Ensembl chr12:37,668,369...37,677,063
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Metribolone results in increased expression of CDKN2A protein CTD PMID:23272087 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cenpn centromere protein N increases expression ISO Metribolone results in increased expression of CENPN mRNA CTD PMID:17010675 NCBI chr19:49,457,461...49,479,989
Ensembl chr19:49,340,184...49,479,996
JBrowse link
G Chd9 chromodomain helicase DNA binding protein 9 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to CHD9 protein modified form] CTD PMID:28751236 NCBI chr19:17,364,969...17,517,757
Ensembl chr19:17,366,828...17,494,585
JBrowse link
G Chek1 checkpoint kinase 1 increases expression
increases phosphorylation
ISO Metribolone results in increased expression of CHEK1 mRNA
Metribolone results in increased phosphorylation of CHEK1 protein
CTD PMID:19318562 PMID:23272087 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases phosphorylation
ISO [Curcumin co-treated with Metribolone] results in increased phosphorylation of CHEK2 protein
Metribolone results in increased phosphorylation of CHEK2 protein
CTD PMID:21134073 PMID:23272087 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Cilk1 ciliogenesis associated kinase 1 increases expression ISO Metribolone results in increased expression of CILK1 mRNA CTD PMID:17010196 NCBI chr 8:85,413,998...85,473,374
Ensembl chr 8:85,413,537...85,472,694
JBrowse link
G Ckb creatine kinase B increases expression ISO Metribolone results in increased expression of CKB protein CTD PMID:17152098 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Cldn3 claudin 3 increases expression ISO Metribolone results in increased expression of CLDN3 mRNA CTD PMID:17010196 NCBI chr12:21,831,341...21,832,813
Ensembl chr12:21,831,342...21,832,813
JBrowse link
G Cltc clathrin heavy chain multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to CLTC protein] CTD PMID:17220478 NCBI chr10:74,014,560...74,070,578
Ensembl chr10:74,014,562...74,070,266
JBrowse link
G Clu clusterin decreases expression
multiple interactions
increases expression
ISO Metribolone results in decreased expression of CLU mRNA alternative form
bicalutamide inhibits the reaction [Metribolone results in increased expression of CLU mRNA]; bicalutamide inhibits the reaction [Metribolone results in increased expression of CLU protein]; Metribolone promotes the reaction [AR protein binds to CLU enhancer]
Metribolone results in increased expression of CLU mRNA; Metribolone results in increased expression of CLU mRNA alternative form; Metribolone results in increased expression of CLU protein
CTD PMID:17010196 PMID:17148459 PMID:17325745 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cndp2 carnosine dipeptidase 2 multiple interactions
increases expression
ISO Metribolone promotes the reaction [NDRG1 protein binds to CNDP2 protein]
Metribolone results in increased expression of CNDP2 protein
CTD PMID:17152098 PMID:17220478 NCBI chr18:81,521,966...81,539,065
Ensembl chr18:81,521,968...81,539,065
JBrowse link
G Cnot1 CCR4-NOT transcription complex, subunit 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to CNOT1 protein modified form] CTD PMID:28751236 NCBI chr19:9,668,186...9,761,605
Ensembl chr19:9,668,186...9,761,605
JBrowse link
G Copb2 COPI coat complex subunit beta 2 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to COPB2 protein] CTD PMID:17220478 NCBI chr 8:106,582,339...106,603,763 JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
EXP Metribolone results in increased phosphorylation of CREB1 protein
RTKI cpd inhibits the reaction [Metribolone results in increased phosphorylation of CREB1 protein]
CTD PMID:17272394 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crebbp CREB binding protein multiple interactions
decreases expression
ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CREBBP protein modified form]; bicalutamide inhibits the reaction [Metribolone results in decreased expression of CREBBP protein]; Metribolone inhibits the reaction [CREBBP protein results in increased activity of AR protein]
Metribolone results in decreased expression of CREBBP mRNA; Metribolone results in decreased expression of CREBBP protein
CTD PMID:11981028 PMID:15378487 PMID:28751236 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Crls1 cardiolipin synthase 1 increases expression ISO Metribolone results in increased expression of CRLS1 mRNA CTD PMID:16751804 NCBI chr 3:125,503,638...125,522,460
Ensembl chr 3:125,503,638...125,522,441
JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 affects splicing ISO Metribolone affects the splicing of CSNK1A1 mRNA CTD PMID:17010196 NCBI chr18:56,887,722...56,910,610
Ensembl chr18:56,887,354...56,918,345
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to CTNNB1 protein] CTD PMID:17220478 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctsb cathepsin B decreases expression ISO Metribolone results in decreased expression of CTSB protein CTD PMID:17152098 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Ctsd cathepsin D decreases expression ISO Metribolone results in decreased expression of CTSD protein CTD PMID:17152098 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cwc27 CWC27 spliceosome associated cyclophilin increases expression ISO Metribolone results in increased expression of CWC27 mRNA CTD PMID:17010196 NCBI chr 2:34,716,420...34,923,060
Ensembl chr 2:34,719,344...34,923,024
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression
multiple interactions
ISO Metribolone results in increased expression of CXCR4 mRNA
Dapsone analog inhibits the reaction [Metribolone results in increased expression of CXCR4 mRNA]
CTD PMID:21440447 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Dars1 aspartyl-tRNA synthetase 1 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to DARS1 protein] CTD PMID:17220478 NCBI chr13:45,074,067...45,127,815
Ensembl chr13:45,074,072...45,127,815
JBrowse link
G Dcun1d1 defective in cullin neddylation 1 domain containing 1 decreases expression ISO Metribolone results in decreased expression of DCUN1D1 protein CTD PMID:17152098 NCBI chr 2:122,476,173...122,527,153
Ensembl chr 2:122,476,173...122,646,445
JBrowse link
G Ddx1 DEAD-box helicase 1 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to DDX1 protein] CTD PMID:17220478 NCBI chr 6:38,422,892...38,453,762
Ensembl chr 6:38,422,888...38,453,797
JBrowse link
G Ddx5 DEAD-box helicase 5 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to DDX5 protein] CTD PMID:17220478 NCBI chr10:94,979,759...94,988,461
Ensembl chr10:94,980,928...94,988,461
JBrowse link
G Dek DEK proto-oncogene increases expression ISO Metribolone results in increased expression of DEK mRNA; Metribolone results in increased expression of DEK protein CTD PMID:23071688 NCBI chr17:17,965,872...17,987,836
Ensembl chr17:17,965,881...17,987,834
JBrowse link
G Dhx30 DExH-box helicase 30 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to DHX30 protein modified form] CTD PMID:28751236 NCBI chr 8:118,160,315...118,194,674
Ensembl chr 8:118,160,299...118,187,791
JBrowse link
G Dlg5 discs large MAGUK scaffold protein 5 increases expression ISO Metribolone results in increased expression of DLG5 mRNA CTD PMID:17010196 NCBI chr15:120,213...230,312
Ensembl chr15:120,372...228,977
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to DLST protein] CTD PMID:17220478 NCBI chr 6:108,936,534...108,961,322
Ensembl chr 6:108,936,664...108,959,803
JBrowse link
G Drd4 dopamine receptor D4 multiple interactions ISO Metribolone inhibits the reaction [Ketoconazole results in decreased expression of DRD4 mRNA] CTD PMID:19587329 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Dynll2 dynein light chain LC8-type 2 increases expression ISO Metribolone results in increased expression of DYNLL2 mRNA CTD PMID:16751804 NCBI chr10:75,262,536...75,281,302
Ensembl chr10:75,262,537...75,270,561
JBrowse link
G Eaf2 ELL associated factor 2 increases expression ISO Metribolone results in increased expression of EAF2 mRNA CTD PMID:17010675 NCBI chr11:66,878,658...66,923,092
Ensembl chr11:66,878,658...66,923,092
JBrowse link
G Ebag9 estrogen receptor binding site associated, antigen, 9 increases expression ISO Metribolone results in increased expression of EBAG9 mRNA CTD PMID:17010196 NCBI chr 7:83,564,563...83,582,516
Ensembl chr 7:83,564,563...83,582,508
JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to EEF1G protein] CTD PMID:17220478 NCBI chr 1:225,163,391...225,173,997
Ensembl chr 1:225,163,391...225,173,995
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 multiple interactions
increases expression
ISO Metribolone promotes the reaction [NDRG1 protein binds to EEF2 protein]
Metribolone results in increased expression of EEF2 protein
CTD PMID:17152098 PMID:17220478 NCBI chr 7:11,401,501...11,406,771
Ensembl chr 7:11,401,501...11,406,771
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP Metribolone results in increased phosphorylation of and results in increased activity of EGFR protein CTD PMID:17272394 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif2s3 eukaryotic translation initiation factor 2 subunit gamma multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to EIF2S3 protein] CTD PMID:17220478 NCBI chr  X:63,268,106...63,291,125
Ensembl chr  X:63,268,037...63,292,092
JBrowse link
G Eif3e eukaryotic translation initiation factor 3 subunit E multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to EIF3E protein] CTD PMID:17220478 NCBI chr 7:82,997,694...83,037,231 JBrowse link
G Eif3k eukaryotic translation initiation factor 3, subunit K affects splicing ISO Metribolone affects the splicing of EIF3K mRNA CTD PMID:17010196 NCBI chr 1:87,927,142...87,937,033
Ensembl chr 1:87,927,141...87,937,516
JBrowse link
G Elac2 elaC ribonuclease Z 2 increases expression ISO Metribolone results in increased expression of ELAC2 mRNA CTD PMID:17010196 NCBI chr10:51,478,378...51,501,167
Ensembl chr10:51,478,378...51,501,165
JBrowse link
G Elk4 ETS transcription factor ELK4 multiple interactions
increases expression
ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of ELK4 mRNA] CTD PMID:21440447 NCBI chr13:48,788,262...48,813,267
Ensembl chr13:48,790,509...48,813,260
JBrowse link
G Ell2 elongation factor for RNA polymerase II 2 increases expression ISO Metribolone results in increased expression of ELL2 mRNA CTD PMID:16751804 PMID:17010675 NCBI chr 2:2,456,189...2,525,590
Ensembl chr 2:2,456,735...2,524,237
JBrowse link
G Eno2 enolase 2 decreases expression ISO Metribolone results in decreased expression of ENO2 protein CTD PMID:17152098 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
JBrowse link
G Entr1 endosome associated trafficking regulator 1 increases expression ISO Metribolone results in increased expression of ENTR1 mRNA CTD PMID:17010196 NCBI chr 3:3,827,498...3,834,219
Ensembl chr 3:3,827,498...3,834,210
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to EP300 protein modified form] CTD PMID:28751236 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Ephx2 epoxide hydrolase 2 increases expression ISO Metribolone results in increased expression of EPHX2 protein CTD PMID:17152098 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Eppin epididymal peptidase inhibitor multiple interactions ISO Metribolone inhibits the reaction [Ketoconazole results in decreased expression of EPPIN mRNA] CTD PMID:19587329 NCBI chr 3:161,043,761...161,050,550
Ensembl chr 3:161,041,727...161,050,557
JBrowse link
G Erg ETS transcription factor ERG multiple interactions ISO [ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]] which results in increased expression of ERG mRNA CTD PMID:23272087 NCBI chr11:35,645,317...35,749,637
Ensembl chr11:35,646,116...35,749,594
JBrowse link
G Ergic3 ERGIC and golgi 3 increases expression ISO Metribolone results in increased expression of ERGIC3 mRNA CTD PMID:17010196 NCBI chr 3:151,553,567...151,563,318
Ensembl chr 3:151,553,578...151,563,364
JBrowse link
G Erp44 endoplasmic reticulum protein 44 increases expression ISO Metribolone results in increased expression of ERP44 protein CTD PMID:17152098 NCBI chr 5:63,937,866...64,030,827
Ensembl chr 5:63,937,784...64,030,901
JBrowse link
G Evi5 ecotropic viral integration site 5 increases expression ISO Metribolone results in increased expression of EVI5 mRNA CTD PMID:16751804 NCBI chr14:2,892,738...3,038,237
Ensembl chr14:2,892,753...3,038,237
JBrowse link
G Ewsr1 EWS RNA-binding protein 1 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to EWSR1 protein] CTD PMID:17220478 NCBI chr14:85,322,105...85,350,826
Ensembl chr14:85,322,296...85,350,948
JBrowse link
G Ezr ezrin multiple interactions
increases phosphorylation
increases expression
ISO bicalutamide inhibits the reaction [Metribolone results in increased expression of EZR mRNA]; bicalutamide inhibits the reaction [Metribolone results in increased phosphorylation of EZR protein]; Metribolone promotes the reaction [EZR protein binds to PRKCA protein]; PRKCA protein affects the reaction [Metribolone results in increased phosphorylation of EZR protein] CTD PMID:16873375 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G Fads1 fatty acid desaturase 1 increases expression ISO Metribolone results in increased expression of FADS1 mRNA CTD PMID:16751804 NCBI chr 1:226,234,034...226,249,118
Ensembl chr 1:226,234,074...226,249,138
JBrowse link
G Fasn fatty acid synthase increases expression
multiple interactions
ISO Metribolone results in increased expression of FASN protein
Metribolone promotes the reaction [NDRG1 protein binds to FASN protein]
CTD PMID:17152098 PMID:17220478 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression ISO Metribolone results in increased expression of FDFT1 mRNA; Metribolone results in increased expression of FDFT1 protein CTD PMID:17483544 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions
increases expression
ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of FKBP5 mRNA]
Metribolone results in increased expression of FKBP5 mRNA; Metribolone results in increased expression of FKBP5 protein
CTD PMID:16751804 PMID:17010675 PMID:17152098 PMID:21440447 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020
JBrowse link
G Fkbp8 FKBP prolyl isomerase 8 decreases expression ISO Metribolone results in decreased expression of FKBP8 protein CTD PMID:17152098 NCBI chr16:20,645,956...20,652,890
Ensembl chr16:20,645,957...20,652,889
JBrowse link
G Folh1 folate hydrolase 1 multiple interactions
decreases expression
ISO 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane analog inhibits the reaction [Metribolone results in decreased expression of FOLH1 mRNA]; [Metribolone co-treated with tris(1,3-dichloro-2-propyl)phosphate] affects the expression of FOLH1 mRNA; [Metribolone co-treated with tris(1,3-dichloro-2-propyl)phosphate] affects the expression of FOLH1 protein; DDT inhibits the reaction [Metribolone results in decreased expression of FOLH1 mRNA]; DDT inhibits the reaction [Metribolone results in decreased expression of FOLH1 protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone results in decreased expression of FOLH1 mRNA]
Metribolone results in decreased expression of FOLH1 mRNA; Metribolone results in decreased expression of FOLH1 protein
CTD PMID:12711008 PMID:17152098 PMID:25682698 PMID:26709203 PMID:26729308 NCBI chr 1:150,323,768...150,395,415
Ensembl chr 1:150,323,768...150,395,415
JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression
multiple interactions
ISO Metribolone results in increased expression of FSHB mRNA
AR protein promotes the reaction [Metribolone results in increased expression of FSHB mRNA]
CTD PMID:16675544 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression ISO Metribolone results in decreased expression of FTH1 protein CTD PMID:17152098 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases expression ISO Metribolone results in decreased expression of G6PD protein CTD PMID:17152098 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Ganab glucosidase II alpha subunit increases expression ISO Metribolone results in increased expression of GANAB protein CTD PMID:17152098 NCBI chr 1:225,096,558...225,116,384
Ensembl chr 1:225,096,598...225,116,378
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Metribolone results in increased expression of GDF15 mRNA CTD PMID:17010196 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gfm1 G elongation factor, mitochondrial 1 increases expression ISO Metribolone results in increased expression of GFM1 protein CTD PMID:17152098 NCBI chr 2:164,601,575...164,646,478
Ensembl chr 2:164,601,586...164,646,439
JBrowse link
G Ggct gamma-glutamyl cyclotransferase decreases expression ISO Metribolone results in decreased expression of GGCT protein CTD PMID:17152098 NCBI chr 4:85,186,644...85,192,857
Ensembl chr 4:85,186,644...85,192,834
JBrowse link
G Glod4 glyoxalase domain containing 4 decreases expression ISO Metribolone results in decreased expression of GLOD4 protein CTD PMID:17152098 NCBI chr10:64,379,922...64,398,263
Ensembl chr10:64,379,921...64,398,294
JBrowse link
G Glra2 glycine receptor, alpha 2 decreases expression ISO Metribolone results in decreased expression of GLRA2 mRNA CTD PMID:17010675 NCBI chr  X:30,612,894...30,832,078
Ensembl chr  X:30,612,903...30,831,483
JBrowse link
G Glul glutamate-ammonia ligase increases expression ISO Metribolone results in increased expression of GLUL protein CTD PMID:17152098 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Gnai3 G protein subunit alpha i3 increases expression ISO Metribolone results in increased expression of GNAI3 mRNA CTD PMID:16751804 NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749
JBrowse link
G Gnaq G protein subunit alpha q multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to GNAQ protein modified form] CTD PMID:28751236 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786
JBrowse link
G Gnmt glycine N-methyltransferase increases expression ISO Metribolone results in increased expression of GNMT mRNA CTD PMID:17010675 NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627
JBrowse link
G Golm2 golgi membrane protein 2 increases expression ISO Metribolone results in increased expression of GOLM2 mRNA CTD PMID:17010196 NCBI chr 3:113,818,649...113,887,550
Ensembl chr 3:113,818,872...113,887,495
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 increases expression ISO Metribolone results in increased expression of GOT2 protein CTD PMID:17626249 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 multiple interactions ISO Metribolone inhibits the reaction [Ketoconazole results in decreased expression of GPD1 mRNA] CTD PMID:19587329 NCBI chr 7:141,368,928...141,377,931
Ensembl chr 7:141,370,491...141,377,928
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression
ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of GREB1 mRNA] CTD PMID:16496412 PMID:21440447 NCBI chr 6:41,932,941...42,002,770
Ensembl chr 6:41,932,244...42,002,819
JBrowse link
G Gsn gelsolin multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to GSN protein modified form] CTD PMID:28751236 NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
JBrowse link
G Gspt1 G1 to S phase transition 1 increases expression ISO Metribolone results in increased expression of GSPT1 protein CTD PMID:17152098 NCBI chr10:4,313,100...4,347,661
Ensembl chr10:4,312,863...4,446,200
JBrowse link
G Gss glutathione synthetase increases expression ISO Metribolone results in increased expression of GSS protein CTD PMID:17152098 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression
ISO [ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]] which results in increased expression of ERG mRNA; [Curcumin co-treated with Metribolone] results in increased phosphorylation of H2AX protein; ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]; ATR mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein] CTD PMID:21134073 PMID:23272087 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Helz2 helicase with zinc finger 2 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to HELZ2 protein modified form] CTD PMID:28751236 NCBI chr 3:176,730,024...176,744,382
Ensembl chr 3:176,731,769...176,744,377
JBrowse link
G Herc3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 increases expression ISO Metribolone results in increased expression of HERC3 mRNA CTD PMID:17010675 NCBI chr 4:89,078,670...89,169,150
Ensembl chr 4:89,078,711...89,169,146
JBrowse link
G Hexb hexosaminidase subunit beta increases expression ISO Metribolone results in increased expression of HEXB mRNA CTD PMID:17010196 NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186
JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase decreases expression ISO Metribolone results in decreased expression of HIBADH protein CTD PMID:17152098 NCBI chr 4:82,604,369...82,702,429
Ensembl chr 4:82,604,373...82,702,429
JBrowse link
G Hid1 HID1 domain containing increases expression ISO Metribolone results in increased expression of HID1 mRNA CTD PMID:17010196 NCBI chr10:103,899,160...103,919,649
Ensembl chr10:103,899,150...103,919,605
JBrowse link
G Hmgb1 high mobility group box 1 decreases expression ISO Metribolone results in decreased expression of HMGB1 protein CTD PMID:17152098 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO Metribolone results in increased expression of HMGCR mRNA; Metribolone results in increased expression of HMGCR protein CTD PMID:16751804 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Metribolone results in increased expression of HMGCS1 protein CTD PMID:17152098 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C decreases expression ISO Metribolone results in decreased expression of HNRNPC protein CTD PMID:17152098 NCBI chr15:28,486,605...28,517,353
Ensembl chr15:28,486,617...28,517,353
JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F multiple interactions
increases expression
ISO Metribolone promotes the reaction [NDRG1 protein binds to HNRNPF protein]
Metribolone results in increased expression of HNRNPF protein
CTD PMID:17152098 PMID:17220478 NCBI chr 4:149,957,143...149,978,896
Ensembl chr 4:149,957,206...149,978,895
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to HNRNPH1 protein] CTD PMID:17220478 NCBI chr10:35,872,619...35,879,911
Ensembl chr10:35,870,232...35,879,910
JBrowse link
G Hnrnph2 heterogeneous nuclear ribonucleoprotein H2 decreases expression ISO Metribolone results in decreased expression of HNRNPH2 protein CTD PMID:17152098 NCBI chr  X:105,417,603...105,423,531
Ensembl chr  X:105,419,285...105,422,861
JBrowse link
G Hnrnph3 heterogeneous nuclear ribonucleoprotein H3 decreases expression ISO Metribolone results in decreased expression of HNRNPH3 protein CTD PMID:17152098 NCBI chr20:27,167,926...27,178,172
Ensembl chr20:27,169,267...27,216,941
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K decreases expression ISO Metribolone results in decreased expression of HNRNPK protein CTD PMID:17152098 NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654
JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to HNRNPU protein] CTD PMID:17220478 NCBI chr13:96,222,093...96,238,845
Ensembl chr13:96,225,912...96,238,572
JBrowse link
G Hr HR, lysine demethylase and nuclear receptor corepressor multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to HR protein modified form] CTD PMID:28751236 NCBI chr15:52,241,801...52,261,276
Ensembl chr15:52,241,801...52,261,276
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to HSD17B4 protein] CTD PMID:17220478 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to HSP90AA1 protein] CTD PMID:17220478 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 affects localization
increases expression
multiple interactions
ISO Metribolone affects the localization of HSPA5 protein
Metribolone results in increased expression of HSPA5 protein
Metribolone promotes the reaction [NDRG1 protein binds to HSPA5 protein]
CTD PMID:17152098 PMID:17220478 PMID:17440980 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO Metribolone results in increased expression of HSPB1 protein CTD PMID:17152098 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Htra2 HtrA serine peptidase 2 decreases expression ISO Metribolone results in decreased expression of HTRA2 protein CTD PMID:17152098 NCBI chr 4:113,883,671...113,886,833
Ensembl chr 4:113,883,670...113,886,994
JBrowse link
G Hus1 HUS1 checkpoint clamp component increases expression ISO Metribolone results in increased expression of HUS1 mRNA CTD PMID:19318562 NCBI chr14:89,194,086...89,208,825
Ensembl chr14:89,194,092...89,208,825
JBrowse link
G Hyou1 hypoxia up-regulated 1 increases expression ISO Metribolone results in increased expression of HYOU1 protein CTD PMID:17152098 NCBI chr 8:48,699,796...48,711,912
Ensembl chr 8:48,699,769...48,711,910
JBrowse link
G Ide insulin degrading enzyme increases expression ISO Metribolone results in increased expression of IDE protein CTD PMID:17152098 NCBI chr 1:255,914,465...256,014,168
Ensembl chr 1:255,914,447...256,013,495
JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 increases expression ISO Metribolone results in increased expression of IDH1 protein CTD PMID:17152098 NCBI chr 9:71,882,108...71,911,645
Ensembl chr 9:71,882,105...71,900,044
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression ISO Metribolone results in increased expression of IDI1 protein CTD PMID:17152098 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
increases expression
ISO [Metribolone co-treated with tris(1,3-dichloro-2-propyl)phosphate] results in decreased expression of IGF1 mRNA; DDT affects the reaction [Metribolone results in increased expression of IGF1 mRNA]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone results in increased expression of IGF1 mRNA] CTD PMID:25682698 PMID:26709203 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf1r insulin-like growth factor 1 receptor increases expression
multiple interactions
ISO Metribolone results in increased expression of IGF1R mRNA
Dapsone analog inhibits the reaction [Metribolone results in increased expression of IGF1R mRNA]; resveratrol inhibits the reaction [Metribolone results in increased expression of IGF1R mRNA]
CTD PMID:18586690 PMID:21440447 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions
increases expression
ISO [Calcitriol co-treated with Metribolone] results in increased expression of IGFBP3 mRNA; Metribolone promotes the reaction [AR protein binds to IGFBP3 promoter]
Metribolone results in increased expression of IGFBP3 mRNA
CTD PMID:16825320 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Il6 interleukin 6 multiple interactions ISO IL6 protein inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:17219378 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ilf3 interleukin enhancer binding factor 3 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to ILF3 protein] CTD PMID:17220478 NCBI chr 8:22,402,877...22,440,984
Ensembl chr 8:22,402,890...22,440,885
JBrowse link
G Immt inner membrane mitochondrial protein increases expression ISO Metribolone results in increased expression of IMMT protein CTD PMID:17152098 NCBI chr 4:99,753,446...99,789,921
Ensembl chr 4:99,753,500...99,792,484
JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO Metribolone results in increased expression of INSIG1 mRNA; Metribolone results in increased expression of INSIG1 protein CTD PMID:16751804 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions ISO Metribolone results in decreased expression of [ITGA2 protein binds to ITGB1 protein] CTD PMID:17541959 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO Metribolone results in decreased expression of [ITGA2 protein binds to ITGB1 protein] CTD PMID:17541959 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Itgb3bp integrin subunit beta 3 binding protein multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to ITGB3BP protein modified form] CTD PMID:28751236 NCBI chr 5:118,476,410...118,541,928
Ensembl chr 5:118,476,430...118,673,780
JBrowse link
G Jmjd1c jumonji domain containing 1C multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to JMJD1C protein modified form] CTD PMID:28751236 NCBI chr20:22,751,743...22,914,080
Ensembl chr20:22,751,743...22,882,672
JBrowse link
G Jtb jumping translocation breakpoint increases expression ISO Metribolone results in increased expression of JTB mRNA CTD PMID:17010196 NCBI chr 2:189,591,707...189,595,926
Ensembl chr 2:189,591,780...189,596,421
JBrowse link
G Kat2b lysine acetyltransferase 2B multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to KAT2B protein modified form] CTD PMID:28751236 NCBI chr 9:4,440,982...4,492,949 JBrowse link
G Kdm3a lysine demethylase 3A multiple interactions
increases expression
ISO Metribolone promotes the reaction [KDM3A protein binds to KLK3 enhancer]; Metribolone promotes the reaction [KDM3A protein binds to NKX3-1 enhancer]
Metribolone results in increased expression of KDM3A protein
CTD PMID:16603237 NCBI chr 4:99,503,160...99,547,315
Ensembl chr 4:99,503,176...99,546,905
JBrowse link
G Kif5b kinesin family member 5B multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to KIF5B protein] CTD PMID:17220478 NCBI chr17:54,181,416...54,219,048
Ensembl chr17:54,181,419...54,212,096
JBrowse link
G Krt1 keratin 1 decreases expression ISO Metribolone results in decreased expression of KRT1 protein CTD PMID:17152098 NCBI chr 7:143,448,318...143,453,544
Ensembl chr 7:143,448,318...143,453,544
JBrowse link
G Krt10 keratin 10 decreases expression ISO Metribolone results in decreased expression of KRT10 protein CTD PMID:17152098 NCBI chr10:87,296,445...87,301,307
Ensembl chr10:87,296,451...87,300,736
JBrowse link
G Krt18 keratin 18 increases expression ISO Metribolone results in increased expression of KRT18 protein CTD PMID:17152098 PMID:17541959 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt8 keratin 8 increases expression ISO Metribolone results in increased expression of KRT8 mRNA; Metribolone results in increased expression of KRT8 protein CTD PMID:17010196 PMID:17152098 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Lcor ligand dependent nuclear receptor corepressor multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to LCOR protein modified form] CTD PMID:28751236 NCBI chr 1:260,775,091...260,839,549
Ensembl chr 1:260,732,485...260,830,854
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to LDHA protein] CTD PMID:17220478 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Ldhd lactate dehydrogenase D increases expression ISO Metribolone results in increased expression of LDHD protein CTD PMID:17152098 NCBI chr19:43,826,989...43,848,937
Ensembl chr19:43,826,993...43,848,937
JBrowse link
G Ldlr low density lipoprotein receptor affects localization ISO Metribolone affects the localization of LDLR protein CTD PMID:17440980 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lgals8 galectin 8 increases expression ISO Metribolone results in increased expression of LGALS8 mRNA CTD PMID:17010196 NCBI chr17:66,487,451...66,515,316
Ensembl chr17:66,487,457...66,511,870
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression ISO Metribolone results in decreased expression of LHB mRNA CTD PMID:16675544 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Lhpp phospholysine phosphohistidine inorganic pyrophosphate phosphatase affects splicing ISO Metribolone affects the splicing of LHPP mRNA CTD PMID:17010196 NCBI chr 1:204,617,804...204,708,987
Ensembl chr 1:204,617,852...204,708,987
JBrowse link
G Lmna lamin A/C decreases expression ISO Metribolone results in decreased expression of LMNA protein CTD PMID:17152098 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516
JBrowse link
G LOC100361854 ribosomal protein S26-like multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPS26 protein] CTD PMID:17220478 NCBI chr  X:115,495,660...115,496,062
Ensembl chr  X:115,495,698...115,496,045
JBrowse link
G LOC100911204 protein CASC5-like increases expression ISO Metribolone results in increased expression of KNL1 mRNA CTD PMID:17010196 NCBI chr 3:112,531,429...112,560,698
Ensembl chr 3:112,531,703...112,560,634
JBrowse link
G LOC498222 similar to specifically androgen-regulated protein increases expression ISO Metribolone results in increased expression of C1ORF116 mRNA CTD PMID:17010675 NCBI chr13:47,452,436...47,467,432
Ensembl chr13:47,454,591...47,467,432
JBrowse link
G Lratd2 LRAT domain containing 2 increases expression ISO Metribolone results in increased expression of LRATD2 mRNA CTD PMID:17010196 NCBI chr 7:101,138,188...101,142,123
Ensembl chr 7:101,139,376...101,140,308
JBrowse link
G Lsm1 LSM1 homolog, mRNA degradation associated increases expression ISO Metribolone results in increased expression of LSM1 mRNA CTD PMID:17010196 NCBI chr16:71,046,475...71,057,883
Ensembl chr16:71,046,475...71,057,883
JBrowse link
G Lta4h leukotriene A4 hydrolase increases expression ISO Metribolone results in increased expression of LTA4H protein CTD PMID:17152098 NCBI chr 7:34,288,333...34,320,243
Ensembl chr 7:34,288,365...34,320,235
JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 decreases expression ISO Metribolone results in decreased expression of MAD1L1 protein CTD PMID:17152098 NCBI chr12:16,410,083...16,721,232
Ensembl chr12:16,410,083...16,719,824
JBrowse link
G Maf MAF bZIP transcription factor multiple interactions
increases expression
ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of MAF mRNA] CTD PMID:16751804 PMID:17010675 PMID:21440447 NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748
JBrowse link
G Maged2 MAGE family member D2 increases expression ISO Metribolone results in increased expression of MAGED2 mRNA CTD PMID:17010196 NCBI chr 5:33,174,539...33,182,715
Ensembl chr 5:33,174,542...33,182,715
JBrowse link
G Mak male germ cell-associated kinase multiple interactions
increases expression
ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of MAK mRNA] CTD PMID:21440447 NCBI chr17:21,531,651...21,567,742
Ensembl chr17:21,521,505...21,568,440
JBrowse link
G Man1a1 mannosidase, alpha, class 1A, member 1 decreases expression ISO Metribolone results in decreased expression of MAN1A1 mRNA CTD PMID:17010675 NCBI chr20:35,257,688...35,450,132
Ensembl chr20:35,257,985...35,450,513
JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to MAOA protein] CTD PMID:17220478 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Map7 microtubule-associated protein 7 increases expression ISO Metribolone results in increased expression of MAP7 mRNA CTD PMID:16751804 NCBI chr 1:15,620,665...15,748,203
Ensembl chr 1:15,620,653...15,748,203
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP RTKI cpd inhibits the reaction [Metribolone results in increased phosphorylation of MAPK1 protein] CTD PMID:17272394 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
EXP Metribolone results in increased phosphorylation of MAPK3 protein
RTKI cpd inhibits the reaction [Metribolone results in increased phosphorylation of MAPK3 protein]
CTD PMID:17272394 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapre2 microtubule-associated protein, RP/EB family, member 2 decreases expression ISO Metribolone results in decreased expression of MAPRE2 mRNA CTD PMID:17010675 NCBI chr18:14,814,149...15,780,290 JBrowse link
G Mcc MCC regulator of WNT signaling pathway increases expression ISO Metribolone results in increased expression of MCC mRNA CTD PMID:17010196 NCBI chr18:35,683,185...35,817,117
NCBI chr 1:12,006,663...12,128,849
Ensembl chr 1:12,006,660...12,128,845
Ensembl chr18:12,006,660...12,128,845
JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MED1 protein modified form] CTD PMID:28751236 NCBI chr10:86,101,560...86,145,271
Ensembl chr10:86,103,600...86,144,880
JBrowse link
G Med18 mediator complex subunit 18 affects splicing ISO Metribolone affects the splicing of MED18 mRNA CTD PMID:17010196 NCBI chr 5:150,649,136...150,654,123
Ensembl chr 5:150,649,829...150,653,172
JBrowse link
G Med28 mediator complex subunit 28 increases expression ISO Metribolone results in increased expression of MED28 mRNA CTD PMID:16751804 PMID:17010675 NCBI chr14:70,089,225...70,098,021
Ensembl chr14:70,089,225...70,098,021
JBrowse link
G Men1 menin 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MEN1 protein modified form] CTD PMID:28751236 NCBI chr 1:221,704,394...221,710,343
Ensembl chr 1:221,704,493...221,710,331
JBrowse link
G MGC95210 hypothetical LOC287798 increases expression ISO Metribolone results in increased expression of C17ORF80 mRNA CTD PMID:17010196 NCBI chr10:102,199,837...102,210,769
Ensembl chr10:102,199,837...102,210,764
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MGMT protein modified form] CTD PMID:28751236 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mir204 microRNA 204 decreases expression
multiple interactions
ISO Metribolone results in decreased expression of MIR204 mRNA
AR protein affects the reaction [Metribolone results in decreased expression of MIR204 mRNA]; MIR204 mRNA inhibits the reaction [Metribolone results in increased expression of XRN1 protein]
CTD PMID:25797256 NCBI chr 1:240,403,000...240,403,109
Ensembl chr 1:240,403,000...240,403,109
JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to MME protein] CTD PMID:17220478 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Metribolone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP1 mRNA] CTD PMID:8798622 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp16 matrix metallopeptidase 16 decreases expression ISO Metribolone results in decreased expression of MMP16 mRNA CTD PMID:16751804 NCBI chr 5:31,568,344...31,818,368
Ensembl chr 5:31,568,419...31,810,484
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression
multiple interactions
ISO Metribolone results in increased expression of MMP2 mRNA
bicalutamide inhibits the reaction [Metribolone results in increased expression of MMP2 mRNA]
CTD PMID:16888681 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO Metribolone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA] CTD PMID:8798622 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mphosph9 M-phase phosphoprotein 9 increases expression ISO Metribolone results in increased expression of MPHOSPH9 mRNA CTD PMID:17010675 NCBI chr12:37,700,282...37,766,487
Ensembl chr12:37,702,404...37,768,957
JBrowse link
G Mrps11 mitochondrial ribosomal protein S11 increases expression ISO Metribolone results in increased expression of MRPS11 mRNA CTD PMID:17010196 NCBI chr 1:140,477,645...140,487,249
Ensembl chr 1:140,477,868...140,487,248
JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 increases expression ISO Metribolone results in increased expression of ATP6 mRNA CTD PMID:17010196 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression ISO Metribolone results in increased expression of COX1 mRNA CTD PMID:17010196 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III increases expression ISO Metribolone results in increased expression of COX3 mRNA CTD PMID:17010196 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
JBrowse link
G Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 increases expression ISO Metribolone results in increased expression of ND2 mRNA CTD PMID:17010196 NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942
JBrowse link
G Mt-nd4 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 affects splicing
increases expression
ISO Metribolone affects the splicing of ND4 mRNA
Metribolone results in increased expression of ND4 mRNA
CTD PMID:17010196 NCBI chr MT:10,160...11,537
Ensembl chr MT:10,160...11,537
JBrowse link
G Mt3 metallothionein 3 increases expression ISO Metribolone results in increased expression of MT3 mRNA; Metribolone results in increased expression of MT3 protein CTD PMID:23794209 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139
JBrowse link
G Mterf4 mitochondrial transcription termination factor 4 increases expression ISO Metribolone results in increased expression of MTERF4 mRNA CTD PMID:16751804 NCBI chr 9:100,440,482...100,445,158
Ensembl chr 9:100,440,486...100,445,158
JBrowse link
G Myl6b myosin light chain 6B affects splicing ISO Metribolone affects the splicing of MYL6B mRNA CTD PMID:17010196 NCBI chr  X:43,831,778...43,833,044 JBrowse link
G Naa15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit increases expression ISO Metribolone results in increased expression of NAA15 mRNA CTD PMID:17010196 NCBI chr 2:140,471,437...140,534,259
Ensembl chr 2:140,471,690...140,534,259
JBrowse link
G Nans N-acetylneuraminate synthase increases expression ISO Metribolone results in increased expression of NANS protein CTD PMID:17152098 NCBI chr 5:62,109,352...62,126,492
Ensembl chr 5:62,109,328...62,126,494
JBrowse link
G Napa NSF attachment protein alpha increases expression ISO Metribolone results in increased expression of NAPA protein CTD PMID:17152098 NCBI chr 1:77,994,227...78,012,846
Ensembl chr 1:77,994,203...78,012,845
JBrowse link
G Nav1 neuron navigator 1 decreases expression ISO Metribolone results in decreased expression of NAV1 mRNA CTD PMID:16751804 NCBI chr13:52,260,474...52,515,016
Ensembl chr13:52,267,254...52,514,875
JBrowse link
G Ncl nucleolin multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to NCL protein] CTD PMID:17220478 NCBI chr 9:93,369,119...93,377,643
Ensembl chr 9:93,368,932...93,377,643
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA1 protein modified form]; Metribolone inhibits the reaction [NCOA1 protein results in increased activity of AR protein] CTD PMID:11981028 PMID:28751236 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA2 protein modified form]; arsenic trioxide inhibits the reaction [Metribolone promotes the reaction [NCOA2 protein binds to KLK3 promoter]]; Metribolone promotes the reaction [NCOA2 protein binds to KLK3 promoter] CTD PMID:19131511 PMID:28751236 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOA3 protein modified form]; Metribolone inhibits the reaction [NCOA3 protein results in increased activity of AR protein] CTD PMID:11981028 PMID:28751236 NCBI chr 3:162,692,176...162,788,582
Ensembl chr 3:162,692,185...162,787,548
JBrowse link
G Ncoa6 nuclear receptor coactivator 6 increases expression
multiple interactions
ISO Metribolone results in increased expression of NCOA6 mRNA
[Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA6 protein modified form]
CTD PMID:17010196 PMID:28751236 NCBI chr 3:150,919,317...150,990,391
Ensembl chr 3:150,919,317...150,960,030
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOR1 protein modified form] CTD PMID:28751236 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NCOR2 protein modified form] CTD PMID:28751236 NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701
JBrowse link
G Ndrg1 N-myc downstream regulated 1 multiple interactions
increases expression
ISO Metribolone promotes the reaction [NDRG1 protein binds to ACSL3 protein]; Metribolone promotes the reaction [NDRG1 protein binds to ACTB protein]; Metribolone promotes the reaction [NDRG1 protein binds to AP1M2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to AP2M1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to ATP1A1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to CANX protein]; Metribolone promotes the reaction [NDRG1 protein binds to CLTC protein]; Metribolone promotes the reaction [NDRG1 protein binds to CNDP2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to COPB2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to CTNNB1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to DARS1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to DDX1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to DDX5 protein]; Metribolone promotes the reaction [NDRG1 protein binds to DLST protein]; Metribolone promotes the reaction [NDRG1 protein binds to EEF1G protein]; Metribolone promotes the reaction [NDRG1 protein binds to EEF2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to EIF2S3 protein]; Metribolone promotes the reaction [NDRG1 protein binds to EIF3E protein]; Metribolone promotes the reaction [NDRG1 protein binds to EWSR1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to FASN protein]; Metribolone promotes the reaction [NDRG1 protein binds to HNRNPF protein]; Metribolone promotes the reaction [NDRG1 protein binds to HNRNPH1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to HNRNPU protein]; Metribolone promotes the reaction [NDRG1 protein binds to HSD17B4 protein]; Metribolone promotes the reaction [NDRG1 protein binds to HSP90AA1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to HSPA5 protein]; Metribolone promotes the reaction [NDRG1 protein binds to ILF3 protein]; Metribolone promotes the reaction [NDRG1 protein binds to KIF5B protein]; Metribolone promotes the reaction [NDRG1 protein binds to LDHA protein]; Metribolone promotes the reaction [NDRG1 protein binds to MAOA protein]; Metribolone promotes the reaction [NDRG1 protein binds to MME protein]; Metribolone promotes the reaction [NDRG1 protein binds to NCL protein]; Metribolone promotes the reaction [NDRG1 protein binds to NDRG1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to PABPC1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to PKM protein]; Metribolone promotes the reaction [NDRG1 protein binds to PPP2R2A protein]; Metribolone promotes the reaction [NDRG1 protein binds to PSMC2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to PSMD2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPL24 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPL3 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPL4 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPN2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPS16 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPS20 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPS26 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPS3 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPS6 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPS8 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPS9 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RUVBL2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to SEC23A protein]; Metribolone promotes the reaction [NDRG1 protein binds to SHMT2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to SLC25A6 protein]; Metribolone promotes the reaction [NDRG1 protein binds to TARS1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to TLE3 protein]; Metribolone promotes the reaction [NDRG1 protein binds to UPF1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to VCP protein]; Metribolone promotes the reaction [NDRG1 protein binds to XRCC6 protein]
Metribolone results in increased expression of NDRG1 protein
CTD PMID:17220478 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Ndufa3 NADH:ubiquinone oxidoreductase subunit A3 affects splicing ISO Metribolone affects the splicing of NDUFA3 mRNA CTD PMID:17010196 NCBI chr 1:64,172,462...64,175,174
Ensembl chr 1:64,172,540...64,175,099
JBrowse link
G Nelfb negative elongation factor complex member B multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NELFB protein modified form] CTD PMID:28751236 NCBI chr 3:2,414,448...2,431,148
Ensembl chr 3:2,414,451...2,431,148
JBrowse link
G Nemf nuclear export mediator factor increases expression ISO Metribolone results in increased expression of NEMF mRNA CTD PMID:17010196 NCBI chr 6:91,611,021...91,676,394 JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NFKBIB protein modified form] CTD PMID:28751236 NCBI chr 1:86,941,073...86,948,845
Ensembl chr 1:86,941,074...86,948,845
JBrowse link
G Ngly1 N-glycanase 1 increases expression ISO Metribolone results in increased expression of NGLY1 mRNA CTD PMID:16751804 NCBI chr15:10,405,453...10,455,973
Ensembl chr15:10,405,164...10,455,956
JBrowse link
G Nkx3-1 NK3 homeobox 1 multiple interactions
increases expression
decreases expression
ISO bicalutamide inhibits the reaction [Metribolone results in increased expression of NKX3-1 mRNA]; Dapsone analog inhibits the reaction [Metribolone results in increased expression of NKX3-1 mRNA]; Metribolone promotes the reaction [AR protein binds to NKX3-1 enhancer]; Metribolone promotes the reaction [AR protein binds to NKX3-1 promoter]; Metribolone promotes the reaction [KDM3A protein binds to NKX3-1 enhancer]; Metribolone promotes the reaction [UXT protein binds to NKX3-1 promoter]; TP53 protein inhibits the reaction [Metribolone results in increased expression of NKX3-1 mRNA]; UXT protein affects the reaction [Metribolone results in increased expression of NKX3-1 mRNA]
Metribolone results in increased expression of NKX3-1 mRNA; Metribolone results in increased expression of NKX3-1 protein
Metribolone results in decreased expression of NKX3-1 mRNA
CTD PMID:11751618 PMID:12711008 PMID:16603237 PMID:17010675 PMID:17131305 PMID:17202838 PMID:17303007 PMID:19318562 PMID:21440447 NCBI chr15:51,065,316...51,067,908
Ensembl chr15:51,065,316...51,068,421
JBrowse link
G Nln neurolysin increases expression ISO Metribolone results in increased expression of NLN protein CTD PMID:17152098 NCBI chr 2:34,086,970...34,185,835
Ensembl chr 2:34,087,880...34,185,812
JBrowse link
G Nnmt nicotinamide N-methyltransferase increases expression ISO Metribolone results in increased expression of NNMT mRNA CTD PMID:17010675 NCBI chr 8:52,918,437...52,938,172
Ensembl chr 8:52,925,175...52,937,972
JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor increases expression ISO Metribolone results in increased expression of NPLOC4 protein CTD PMID:17152098 NCBI chr10:109,553,518...109,610,087
Ensembl chr10:109,552,649...109,610,030
JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NR0B1 protein modified form] CTD PMID:28751236 NCBI chr  X:54,734,385...54,738,513
Ensembl chr  X:54,734,385...54,738,513
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NR0B2 protein modified form] CTD PMID:28751236 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO Metribolone binds to and results in decreased activity of NR3C2 protein; Metribolone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] CTD PMID:17105867 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions
increases expression
ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of NR4A1 mRNA] CTD PMID:21440447 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NRIP1 protein modified form] CTD PMID:28751236 NCBI chr11:14,658,225...14,742,478
Ensembl chr11:14,658,225...14,741,563
JBrowse link
G Nucb2 nucleobindin 2 increases expression ISO Metribolone results in increased expression of NUCB2 mRNA CTD PMID:17010196 NCBI chr 1:185,106,773...185,143,278
Ensembl chr 1:185,104,656...185,143,272
JBrowse link
G Oaz1 ornithine decarboxylase antizyme 1 affects splicing ISO Metribolone affects the splicing of OAZ1 mRNA CTD PMID:17010196 NCBI chr 7:11,752,127...11,754,587
Ensembl chr 7:11,752,412...11,754,508
JBrowse link
G Odc1 ornithine decarboxylase 1 decreases expression EXP Metribolone results in decreased expression of ODC1 mRNA CTD PMID:15519604 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Ogdh oxoglutarate dehydrogenase affects splicing ISO Metribolone affects the splicing of OGDH mRNA CTD PMID:17010196 NCBI chr14:86,414,924...86,481,903
Ensembl chr14:86,414,949...86,613,327
JBrowse link
G Orm1 orosomucoid 1 increases expression ISO Metribolone results in increased expression of ORM1 mRNA CTD PMID:16751804 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Osr2 odd-skipped related transciption factor 2 decreases expression ISO Metribolone results in decreased expression of OSR2 mRNA CTD PMID:16751804 NCBI chr 7:74,047,820...74,055,096
Ensembl chr 7:74,047,814...74,055,256
JBrowse link
G Pa2g4 proliferation-associated 2G4 multiple interactions ISO PA2G4 protein inhibits the reaction [Cyproterone Acetate promotes the reaction [Metribolone results in increased expression of AR mRNA]]; PA2G4 protein inhibits the reaction [Metribolone results in increased expression of AR mRNA] CTD PMID:15994225 NCBI chr 7:2,979,587...2,987,055
Ensembl chr 7:2,979,588...2,987,055
JBrowse link
G Pabpc1 poly(A) binding protein, cytoplasmic 1 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to PABPC1 protein] CTD PMID:17220478 NCBI chr 7:75,409,581...75,421,874
Ensembl chr 7:75,409,581...75,422,268
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 decreases expression ISO Metribolone results in decreased expression of PAK2 protein CTD PMID:17152098 NCBI chr11:72,829,407...72,865,815
Ensembl chr11:72,829,238...72,865,902
JBrowse link
G Pank4 pantothenate kinase 4 increases expression ISO Metribolone results in increased expression of PANK4 protein CTD PMID:17152098 NCBI chr 5:172,367,593...172,384,077
Ensembl chr 5:172,367,398...172,384,269
JBrowse link
G Park7 Parkinsonism associated deglycase increases expression ISO Metribolone results in increased expression of PARK7 protein CTD PMID:17152098 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 affects splicing ISO Metribolone affects the splicing of PCMT1 mRNA CTD PMID:17010196 NCBI chr 1:1,734,863...1,767,759
Ensembl chr 1:1,736,276...1,767,618
JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein decreases expression ISO Metribolone results in decreased expression of PDCD6IP protein CTD PMID:17152098 NCBI chr 8:121,916,233...121,973,145
Ensembl chr 8:121,916,185...121,973,125
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 increases expression ISO Metribolone results in increased expression of PDIA3 protein CTD PMID:17152098 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 increases expression ISO Metribolone results in increased expression of PDIA6 protein CTD PMID:17152098 NCBI chr 6:42,568,269...42,585,654
Ensembl chr 6:42,568,220...42,585,652
JBrowse link
G Pds5b PDS5 cohesin associated factor B increases expression ISO Metribolone results in increased expression of PDS5B mRNA CTD PMID:17010196 NCBI chr12:659,995...794,042
Ensembl chr12:660,011...794,042
JBrowse link
G Pdxdc1 pyridoxal-dependent decarboxylase domain containing 1 increases expression ISO Metribolone results in increased expression of PDXDC1 protein CTD PMID:17152098 NCBI chr10:3,232,794...3,321,438
Ensembl chr10:3,232,794...3,321,412
JBrowse link
G Pelp1 proline, glutamate and leucine rich protein 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PELP1 protein modified form] CTD PMID:28751236 NCBI chr10:56,988,076...57,005,111
Ensembl chr10:56,988,052...57,005,272
JBrowse link
G Per1 period circadian regulator 1 multiple interactions
increases expression
ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of PER1 mRNA] CTD PMID:21440447 NCBI chr10:55,681,761...55,696,557
Ensembl chr10:55,687,050...55,695,994
JBrowse link
G Pgm2 phosphoglucomutase 2 increases expression ISO Metribolone results in increased expression of PGM2 protein CTD PMID:17152098 NCBI chr14:45,829,440...45,863,883
Ensembl chr14:45,829,446...45,863,877
JBrowse link
G Pgr progesterone receptor affects binding ISO Metribolone binds to PGR protein CTD PMID:15189034 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Phb prohibitin decreases expression ISO Metribolone results in decreased expression of PHB protein CTD PMID:17152098 NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878
JBrowse link
G Phgdh phosphoglycerate dehydrogenase decreases expression
increases expression
ISO Metribolone results in decreased expression of PHGDH protein
Metribolone results in increased expression of PHGDH protein
CTD PMID:17152098 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 increases expression ISO Metribolone results in increased expression of PIAS1 mRNA CTD PMID:16751804 NCBI chr 8:67,771,720...67,869,015
Ensembl chr 8:67,771,720...67,869,019
JBrowse link
G Pias2 protein inhibitor of activated STAT, 2 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PIAS2 protein modified form] CTD PMID:28751236 NCBI chr18:73,479,863...73,524,956
Ensembl chr18:73,378,662...73,524,956
JBrowse link
G Pip4k2b phosphatidylinositol-5-phosphate 4-kinase type 2 beta decreases expression ISO Metribolone results in decreased expression of PIP4K2B mRNA CTD PMID:17010675 NCBI chr10:85,655,223...85,684,138
Ensembl chr10:85,658,324...85,684,138
JBrowse link
G Pkib cAMP-dependent protein kinase inhibitor beta decreases expression ISO Metribolone results in decreased expression of PKIB mRNA CTD PMID:16751804 NCBI chr20:40,616,868...40,712,598
Ensembl chr20:40,618,128...40,712,592
JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to PKM protein] CTD PMID:17220478 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Plin3 perilipin 3 increases expression ISO Metribolone results in increased expression of PLIN3 protein CTD PMID:17152098 NCBI chr 9:10,769,739...10,781,659
Ensembl chr 9:10,773,901...10,781,109
JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 affects expression
increases expression
ISO Metribolone affects the expression of PMEPA1 mRNA
Metribolone results in increased expression of PMEPA1 mRNA
CTD PMID:12711008 PMID:17010196 PMID:17010675 NCBI chr 3:171,295,630...171,342,662
Ensembl chr 3:171,294,856...171,342,646
JBrowse link
G Potem POTE ankyrin domain family member M increases expression ISO Metribolone results in increased expression of POTEM mRNA CTD PMID:17010196 NCBI chr16:21,947,702...22,118,777
Ensembl chr16:21,955,168...22,116,834
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PPARGC1A protein modified form] CTD PMID:28751236 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Pphln1 periphilin 1 increases expression ISO Metribolone results in increased expression of PPHLN1 mRNA CTD PMID:17010196 NCBI chr 7:134,602,109...134,693,807
Ensembl chr 7:134,603,121...134,695,864
JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha multiple interactions
decreases expression
ISO Metribolone promotes the reaction [NDRG1 protein binds to PPP2R2A protein]
Metribolone results in decreased expression of PPP2R2A protein
CTD PMID:17152098 PMID:17220478 NCBI chr15:43,673,958...43,733,182
Ensembl chr15:43,673,960...43,733,182
JBrowse link
G Pprc1 PPARG related coactivator 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PPRC1 protein modified form] CTD PMID:28751236 NCBI chr 1:265,809,892...265,826,319
Ensembl chr 1:265,809,754...265,826,306
JBrowse link
G Prame PRAME nuclear receptor transcriptional regulator multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PRAME protein modified form] CTD PMID:28751236 NCBI chr  X:106,082,984...106,091,256
Ensembl chr  X:106,083,203...106,085,878
JBrowse link
G Prdm2 PR/SET domain 2 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PRDM2 protein modified form] CTD PMID:28751236 NCBI chr 5:161,769,587...161,879,150
Ensembl chr 5:161,770,653...161,879,133
JBrowse link
G Prdx1 peroxiredoxin 1 affects splicing ISO Metribolone affects the splicing of PRDX1 mRNA CTD PMID:17010196 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prdx3 peroxiredoxin 3 affects localization ISO Metribolone affects the localization of PRDX3 protein CTD PMID:17440980 NCBI chr 1:282,238,774...282,251,193
Ensembl chr 1:282,238,773...282,251,257
JBrowse link
G Prdx6 peroxiredoxin 6 increases expression ISO Metribolone results in increased expression of PRDX6 protein CTD PMID:17152098 NCBI chr13:79,077,567...79,088,113
Ensembl chr13:79,077,033...79,088,127
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta affects expression ISO Metribolone affects the expression of PRKACB mRNA alternative form; Metribolone affects the expression of PRKACB protein alternative form CTD PMID:16949795 NCBI chr 2:252,602,197...252,691,886
Ensembl chr 2:252,605,307...252,691,886
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO Metribolone promotes the reaction [EZR protein binds to PRKCA protein]; PRKCA protein affects the reaction [Metribolone results in increased phosphorylation of EZR protein] CTD PMID:16873375 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prps2 phosphoribosyl pyrophosphate synthetase 2 decreases expression ISO Metribolone results in decreased expression of PRPS2 protein CTD PMID:17152098 NCBI chr  X:28,435,275...28,472,882
Ensembl chr  X:28,435,507...28,472,880
JBrowse link
G Psmc1 proteasome 26S subunit, ATPase 1 increases expression ISO Metribolone results in increased expression of PSMC1 protein CTD PMID:17152098 NCBI chr 6:124,123,283...124,135,644
Ensembl chr 6:124,123,228...124,135,658
JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to PSMC2 protein] CTD PMID:17220478 NCBI chr 4:9,867,132...9,881,383
Ensembl chr 4:9,867,101...9,881,484
JBrowse link
G Psmc3 proteasome 26S subunit, ATPase 3 increases expression ISO Metribolone results in increased expression of PSMC3 protein CTD PMID:17152098 NCBI chr 3:79,876,938...79,882,319
Ensembl chr 3:79,876,938...79,882,319
JBrowse link
G Psmd2 proteasome 26S subunit, non-ATPase 2 multiple interactions
increases expression
ISO Metribolone promotes the reaction [NDRG1 protein binds to PSMD2 protein]
Metribolone results in increased expression of PSMD2 protein
CTD PMID:17152098 PMID:17220478 NCBI chr11:83,934,098...83,944,725
Ensembl chr11:83,934,087...83,944,763
JBrowse link
G Psmd6 proteasome 26S subunit, non-ATPase 6 increases expression ISO Metribolone results in increased expression of PSMD6 mRNA CTD PMID:17010196 NCBI chr15:12,407,557...12,416,153
Ensembl chr15:12,407,524...12,416,105
JBrowse link
G Psme3 proteasome activator subunit 3 decreases expression ISO Metribolone results in decreased expression of PSME3 protein CTD PMID:17152098 NCBI chr10:89,236,256...89,244,041
Ensembl chr10:89,236,256...89,244,041
JBrowse link
G Pten phosphatase and tensin homolog decreases response to substance ISO PTEN protein results in decreased susceptibility to Metribolone CTD PMID:16637073 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptger4 prostaglandin E receptor 4 increases expression ISO Metribolone results in increased expression of PTGER4 mRNA CTD PMID:17010675 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
G Pthlh parathyroid hormone-like hormone decreases expression ISO Metribolone results in decreased expression of PTHLH protein CTD PMID:17676588 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Ptov1 PTOV1, extended AT-hook containing adaptor protein increases expression ISO Metribolone results in increased expression of PTOV1 mRNA CTD PMID:17010196 NCBI chr 1:100,859,346...100,866,917
Ensembl chr 1:100,859,349...100,865,894
JBrowse link
G Ptprm protein tyrosine phosphatase, receptor type, M increases expression ISO Metribolone results in increased expression of PTPRM mRNA CTD PMID:16751804 NCBI chr 9:114,846,095...115,555,261
Ensembl chr 9:114,846,095...115,555,261
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to RBL2 protein modified form] CTD PMID:28751236 NCBI chr19:17,300,088...17,346,865
Ensembl chr19:17,300,089...17,346,808
JBrowse link
G Rbm6 RNA binding motif protein 6 increases expression ISO Metribolone results in increased expression of RBM6 mRNA CTD PMID:17010196 NCBI chr 8:116,535,403...116,635,851
Ensembl chr 8:116,535,403...116,635,851
JBrowse link
G Rdh11 retinol dehydrogenase 11 increases expression ISO Metribolone results in increased expression of RDH11 mRNA CTD PMID:17010196 NCBI chr 6:102,356,498...102,372,618
Ensembl chr 6:102,356,492...102,372,611
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to RELA protein modified form] CTD PMID:28751236 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhou ras homolog family member U increases expression ISO Metribolone results in increased expression of RHOU mRNA CTD PMID:16751804 NCBI chr19:56,431,787...56,443,896
Ensembl chr19:56,435,577...56,441,733
JBrowse link
G Rmc1 regulator of MON1-CCZ1 increases expression ISO Metribolone results in increased expression of RMC1 mRNA CTD PMID:17010196 NCBI chr18:3,597,210...3,617,160
Ensembl chr18:3,597,240...3,617,283
JBrowse link
G Rmdn1 regulator of microtubule dynamics 1 affects localization ISO Metribolone affects the localization of RMDN1 protein CTD PMID:17440980 NCBI chr 5:33,580,891...33,604,564
Ensembl chr 5:33,580,944...33,638,165
JBrowse link
G Rpl11 ribosomal protein L11 affects splicing ISO Metribolone affects the splicing of RPL11 mRNA CTD PMID:17010196 NCBI chr 5:154,390,809...154,394,412
Ensembl chr 5:154,388,140...154,394,328
JBrowse link
G Rpl24 ribosomal protein L24 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPL24 protein] CTD PMID:17220478 NCBI chr11:47,116,885...47,122,093
Ensembl chr11:47,116,886...47,122,095
JBrowse link
G Rpl3 ribosomal protein L3 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPL3 protein] CTD PMID:17220478 NCBI chr 7:121,297,365...121,302,739
Ensembl chr 7:121,297,355...121,311,565
JBrowse link
G Rpl4 ribosomal protein L4 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPL4 protein] CTD PMID:17220478 NCBI chr 8:69,121,682...69,126,805
Ensembl chr 8:69,121,682...69,126,805
JBrowse link
G Rpn2 ribophorin II multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPN2 protein] CTD PMID:17220478 NCBI chr 3:153,398,373...153,445,633
Ensembl chr 3:153,398,130...153,445,632
JBrowse link
G Rps16 ribosomal protein S16 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPS16 protein] CTD PMID:17220478 NCBI chr 1:85,405,499...85,408,444
Ensembl chr 1:85,405,512...85,408,444
JBrowse link
G Rps20 ribosomal protein S20 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPS20 protein] CTD PMID:17220478 NCBI chr 5:16,706,052...16,707,214
Ensembl chr 5:16,706,082...16,706,909
JBrowse link
G Rps27l ribosomal protein S27-like affects splicing ISO Metribolone affects the splicing of RPS27L mRNA CTD PMID:17010196 NCBI chr 8:72,741,155...72,746,090
Ensembl chr 8:72,741,155...72,746,090
JBrowse link
G Rps3 ribosomal protein S3 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPS3 protein] CTD PMID:17220478 NCBI chr 1:164,435,868...164,441,167
Ensembl chr 1:164,435,878...164,441,167
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPS6 protein] CTD PMID:17220478 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Rps8 ribosomal protein S8 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPS8 protein] CTD PMID:17220478 NCBI chr 5:136,020,941...136,023,511
Ensembl chr 5:136,020,941...136,023,511
JBrowse link
G Rps9 ribosomal protein S9 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RPS9 protein] CTD PMID:17220478 NCBI chr 1:64,086,625...64,090,023
Ensembl chr 1:64,018,125...64,090,021
JBrowse link
G Rpsa ribosomal protein SA increases expression ISO Metribolone results in increased expression of RPSA protein CTD PMID:17152098 NCBI chr 8:128,806,053...128,809,987
Ensembl chr 8:128,806,129...128,809,986
JBrowse link
G Rrp12 ribosomal RNA processing 12 homolog increases expression ISO Metribolone results in increased expression of RRP12 mRNA CTD PMID:16751804 NCBI chr 1:261,106,768...261,140,416
Ensembl chr 1:261,106,760...261,140,389
JBrowse link
G Rrp7a ribosomal RNA processing 7 homolog A increases expression ISO Metribolone results in increased expression of RRP7A mRNA CTD PMID:17010196 NCBI chr 7:123,980,251...123,990,139
Ensembl chr 7:123,980,251...123,990,139
JBrowse link
G Ruvbl2 RuvB-like AAA ATPase 2 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to RUVBL2 protein] CTD PMID:17220478 NCBI chr 1:101,413,766...101,426,970
Ensembl chr 1:101,413,766...101,426,852
JBrowse link
G Scp2 sterol carrier protein 2 affects localization ISO Metribolone affects the localization of SCP2 protein CTD PMID:17440980 NCBI chr 5:127,647,934...127,735,703
Ensembl chr 5:127,620,274...127,735,739
JBrowse link
G Sdccag8 SHH signaling and ciliogenesis regulator SDCCAG8 increases expression ISO Metribolone results in increased expression of SDCCAG8 mRNA CTD PMID:17010196 NCBI chr13:94,888,046...95,100,833
Ensembl chr13:94,888,078...95,112,033
JBrowse link
G Sec23a Sec23 homolog A, COPII coat complex component multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to SEC23A protein] CTD PMID:17220478 NCBI chr 6:80,059,742...80,107,340
Ensembl chr 6:80,060,916...80,107,236
JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression ISO Metribolone results in decreased expression of SELENBP1 protein CTD PMID:17152098 NCBI chr 2:196,105,592...196,146,474
Ensembl chr 2:196,105,569...196,113,149
JBrowse link
G Selenop selenoprotein P increases expression
multiple interactions
ISO Metribolone results in increased expression of SELENOP mRNA
resveratrol inhibits the reaction [Metribolone results in increased expression of SELENOP mRNA]
CTD PMID:17131305 PMID:18586690 NCBI chr 2:53,105,912...53,116,198
Ensembl chr 2:53,109,684...53,114,858
JBrowse link
G Septin1 septin 1 increases expression ISO Metribolone results in increased expression of SEPTIN1 mRNA CTD PMID:17010196 NCBI chr 1:198,658,744...198,662,610
Ensembl chr 1:198,658,745...198,662,610
JBrowse link
G Septin2 septin 2 increases expression ISO Metribolone results in increased expression of SEPTIN2 protein CTD PMID:17152098 NCBI chr 9:100,624,876...100,658,053
Ensembl chr 9:100,624,876...100,658,050
JBrowse link
G Serpinb5 serpin family B member 5 decreases expression ISO Metribolone results in decreased expression of SERPINB5 protein CTD PMID:17152098 NCBI chr13:26,903,052...26,923,250
Ensembl chr13:26,903,052...26,923,250
JBrowse link
G Serpine1 serpin family E member 1 increases secretion ISO Metribolone results in increased secretion of SERPINE1 protein CTD PMID:20711410 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sesn1 sestrin 1 multiple interactions
decreases expression
ISO AR protein affects the reaction [Metribolone results in decreased expression of SESN1 protein]
Metribolone results in decreased expression of SESN1 mRNA; Metribolone results in decreased expression of SESN1 protein
CTD PMID:16751804 NCBI chr20:46,667,116...46,758,306
Ensembl chr20:46,667,121...46,758,305
JBrowse link
G Sfxn4 sideroflexin 4 increases expression ISO Metribolone results in increased expression of SFXN4 mRNA CTD PMID:17010196 NCBI chr 1:282,213,610...282,236,851
Ensembl chr 1:282,213,675...282,235,974
JBrowse link
G Sh3glb2 SH3 domain-containing GRB2-like endophilin B2 increases expression ISO Metribolone results in increased expression of SH3GLB2 mRNA CTD PMID:17010196 NCBI chr 3:8,909,231...8,924,066
Ensembl chr 3:8,909,236...8,924,032
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to SHMT2 protein] CTD PMID:17220478 NCBI chr 7:70,824,718...70,829,822
Ensembl chr 7:70,824,715...70,829,815
JBrowse link
G Sil1 SIL1 nucleotide exchange factor increases expression ISO Metribolone results in increased expression of SIL1 protein CTD PMID:17152098 NCBI chr18:28,067,476...28,302,008
Ensembl chr18:28,067,484...28,301,863
JBrowse link
G Slc25a6 solute carrier family 25 member 6 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to SLC25A6 protein] CTD PMID:17220478 NCBI chr18:70,959,872...70,961,040
Ensembl chr18:70,959,887...70,960,786
JBrowse link
G Slc30a3 solute carrier family 30 member 3 increases expression ISO Metribolone results in increased expression of SLC30A3 mRNA CTD PMID:14662799 NCBI chr 6:26,629,752...26,650,106
Ensembl chr 6:26,642,783...26,650,105
JBrowse link
G Slc30a7 solute carrier family 30 member 7 increases expression ISO Metribolone results in increased expression of SLC30A7 mRNA CTD PMID:16751804 NCBI chr 2:218,888,431...218,951,030
Ensembl chr 2:218,888,431...218,951,030
JBrowse link
G Slc30a9 solute carrier family 30 member 9 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to SLC30A9 protein modified form] CTD PMID:28751236 NCBI chr14:42,464,814...42,519,760
Ensembl chr14:42,465,807...42,520,020
JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions
increases expression
ISO [Metribolone results in increased expression of SLC31A1 protein] which results in increased import of Copper; AR protein promotes the reaction [Metribolone results in increased expression of SLC31A1 mRNA]; AR protein promotes the reaction [Metribolone results in increased expression of SLC31A1 protein]
Metribolone results in increased expression of SLC31A1 mRNA; Metribolone results in increased expression of SLC31A1 protein
CTD PMID:25320179 NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358
JBrowse link
G Slc35c2 solute carrier family 35 member C2 increases expression ISO Metribolone results in increased expression of SLC35C2 mRNA CTD PMID:17010196 NCBI chr 3:161,801,194...161,812,318
Ensembl chr 3:161,801,197...161,812,291
JBrowse link
G Slc43a1 solute carrier family 43 member 1 increases expression ISO Metribolone results in increased expression of SLC43A1 mRNA CTD PMID:17010196 NCBI chr 3:72,238,796...72,265,023
Ensembl chr 3:72,238,981...72,264,466
JBrowse link
G Slc45a3 solute carrier family 45, member 3 increases expression ISO Metribolone results in increased expression of SLC45A3 mRNA CTD PMID:17010196 NCBI chr13:48,745,855...48,766,283
Ensembl chr13:48,745,860...48,766,283
JBrowse link
G Sms spermine synthase increases expression ISO Metribolone results in increased expression of SMS protein CTD PMID:17152098 NCBI chr  X:40,363,646...40,415,110
Ensembl chr  X:40,363,646...40,415,109
JBrowse link
G Sncg synuclein, gamma increases expression ISO Metribolone results in increased expression of SNCG mRNA CTD PMID:17010196 NCBI chr16:10,722,110...10,726,648
Ensembl chr16:10,722,106...10,726,707
JBrowse link
G Socs2 suppressor of cytokine signaling 2 increases expression ISO Metribolone results in increased expression of SOCS2 mRNA CTD PMID:16751804 NCBI chr 7:36,495,496...36,500,878
Ensembl chr 7:36,495,480...36,499,784
JBrowse link
G Spcs3 signal peptidase complex subunit 3 increases expression ISO Metribolone results in increased expression of SPCS3 mRNA CTD PMID:16751804 NCBI chr16:40,050,862...40,056,296
Ensembl chr16:40,050,734...40,058,822
JBrowse link
G Spin1 spindlin 1 increases expression ISO Metribolone results in increased expression of SPIN1 mRNA CTD PMID:17010196 NCBI chr16:884,854...930,527
Ensembl chr16:884,861...930,527
JBrowse link
G Spon2 spondin 2 increases expression ISO Metribolone results in increased expression of SPON2 mRNA CTD PMID:17010196 NCBI chr14:82,815,158...82,824,529
Ensembl chr14:82,818,663...82,824,599
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP Metribolone results in increased phosphorylation of and results in increased activity of SRC protein CTD PMID:17272394 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Stard10 StAR-related lipid transfer domain containing 10 increases expression ISO Metribolone results in increased expression of STARD10 mRNA CTD PMID:17010196 NCBI chr 1:166,428,780...166,458,413
Ensembl chr 1:166,428,761...166,457,509
JBrowse link
G Steap1 STEAP family member 1 increases expression ISO Metribolone results in increased expression of STEAP1 mRNA CTD PMID:17010196 NCBI chr 4:25,435,885...25,446,393
Ensembl chr 4:25,435,873...25,446,461
JBrowse link
G Steap2 STEAP2 metalloreductase increases expression ISO Metribolone results in increased expression of STEAP2 mRNA CTD PMID:17010196 NCBI chr 4:25,506,604...25,527,088
Ensembl chr 4:25,507,463...25,527,087
JBrowse link
G Steap4 STEAP4 metalloreductase multiple interactions
increases expression
ISO AR protein promotes the reaction [Metribolone results in increased expression of STEAP4 mRNA] CTD PMID:25320179 NCBI chr 4:23,112,682...23,135,354
Ensembl chr 4:23,090,029...23,135,354
JBrowse link
G Stip1 stress-induced phosphoprotein 1 affects localization
increases expression
ISO Metribolone affects the localization of STIP1 protein
Metribolone results in increased expression of STIP1 protein
CTD PMID:17152098 PMID:17440980 NCBI chr 1:222,274,133...222,293,139
Ensembl chr 1:222,274,133...222,293,148
JBrowse link
G Stk39 serine threonine kinase 39 increases expression
multiple interactions
ISO Metribolone results in increased expression of STK39 mRNA
resveratrol inhibits the reaction [Metribolone results in increased expression of STK39 mRNA]
CTD PMID:17131305 PMID:18586690 NCBI chr 3:54,359,449...54,625,702
Ensembl chr 3:54,359,451...54,625,414
JBrowse link
G Sucla2 succinate-CoA ligase ADP-forming subunit beta increases expression ISO Metribolone results in increased expression of SUCLA2 protein CTD PMID:17152098 NCBI chr15:55,461,695...55,516,954
Ensembl chr15:55,461,695...55,516,952
JBrowse link
G Tacc1 transforming, acidic coiled-coil containing protein 1 increases expression ISO Metribolone results in increased expression of TACC1 mRNA CTD PMID:17010196 NCBI chr16:71,596,970...71,681,126
Ensembl chr16:71,629,525...71,681,126
JBrowse link
G Taldo1 transaldolase 1 decreases expression ISO Metribolone results in decreased expression of TALDO1 protein CTD PMID:17152098 NCBI chr 1:214,375,555...214,385,886
Ensembl chr 1:214,375,515...214,385,885
JBrowse link
G Tardbp TAR DNA binding protein decreases expression ISO Metribolone results in decreased expression of TARDBP protein CTD PMID:17152098 NCBI chr 5:165,432,089...165,442,232
Ensembl chr 5:165,432,095...165,442,048
JBrowse link
G Tars1 threonyl-tRNA synthetase 1 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to TARS1 protein] CTD PMID:17220478 NCBI chr 2:61,394,632...61,414,115
Ensembl chr 2:61,394,770...61,414,102
JBrowse link
G Tbcc tubulin folding cofactor C increases expression ISO Metribolone results in increased expression of TBCC protein CTD PMID:17152098 NCBI chr 9:16,405,187...16,406,338
Ensembl chr 9:16,405,185...16,406,338
JBrowse link
G Tert telomerase reverse transcriptase increases activity
increases expression
multiple interactions
ISO Metribolone results in increased activity of TERT protein
Metribolone results in increased expression of TERT mRNA
letrozole inhibits the reaction [Metribolone results in increased activity of TERT protein]; Metribolone inhibits the reaction [Estradiol results in increased activity of TERT protein]; Tamoxifen inhibits the reaction [Metribolone results in increased activity of TERT protein]
CTD PMID:19561322 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TGFB1I1 protein modified form] CTD PMID:28751236 NCBI chr 1:199,664,039...199,670,970
Ensembl chr 1:199,664,173...199,670,961
JBrowse link
G Tle3 TLE family member 3, transcriptional corepressor multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to TLE3 protein] CTD PMID:17220478 NCBI chr 8:66,296,509...66,342,186
Ensembl chr 8:66,296,883...66,342,176
JBrowse link
G Tmem50a transmembrane protein 50A increases expression ISO Metribolone results in increased expression of TMEM50A mRNA CTD PMID:16751804 NCBI chr 5:153,233,965...153,252,006
Ensembl chr 5:153,233,962...153,252,021
JBrowse link
G Tmprss2 transmembrane serine protease 2 decreases expression
increases expression
multiple interactions
ISO Metribolone results in decreased expression of TMPRSS2 mRNA
Metribolone results in increased expression of TMPRSS2 mRNA
Dapsone analog inhibits the reaction [Metribolone results in increased expression of TMPRSS2 mRNA]
CTD PMID:12711008 PMID:17010675 PMID:21440447 NCBI chr11:38,063,914...38,103,406
Ensembl chr11:38,063,915...38,103,290
JBrowse link
G Tnk1 tyrosine kinase, non-receptor, 1 decreases expression ISO Metribolone results in decreased expression of TNK1 mRNA CTD PMID:17010675 NCBI chr10:56,458,650...56,475,183
Ensembl chr10:56,459,108...56,465,393
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [Curcumin co-treated with Metribolone] results in increased phosphorylation of TP53 protein; TP53 protein inhibits the reaction [Metribolone results in increased expression of NKX3-1 mRNA] CTD PMID:17202838 PMID:21134073 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpx2 TPX2, microtubule nucleation factor increases expression ISO Metribolone results in increased expression of TPX2 mRNA CTD PMID:17010196 NCBI chr 3:148,327,965...148,370,187
Ensembl chr 3:148,327,965...148,370,187
JBrowse link
G Trerf1 transcriptional regulating factor 1 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to TRERF1 protein modified form] CTD PMID:28751236 NCBI chr 9:15,653,230...15,881,695
Ensembl chr 9:15,655,735...15,700,312
JBrowse link
G Trim24 tripartite motif-containing 24 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TRIM24 protein modified form] CTD PMID:28751236 NCBI chr 4:65,632,278...65,684,746
Ensembl chr 4:65,637,407...65,684,743
JBrowse link
G Trim28 tripartite motif-containing 28 decreases expression ISO Metribolone results in decreased expression of TRIM28 protein CTD PMID:17152098 NCBI chr 1:65,544,369...65,551,043
Ensembl chr 1:65,544,373...65,551,043
JBrowse link
G Trps1 transcriptional repressor GATA binding 1 decreases expression ISO Metribolone results in decreased expression of TRPS1 mRNA CTD PMID:19759027 NCBI chr 7:90,085,895...90,320,430
Ensembl chr 7:90,090,828...90,318,221
JBrowse link
G Trrap transformation/transcription domain-associated protein multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TRRAP protein modified form] CTD PMID:28751236 NCBI chr12:11,537,950...11,627,563
Ensembl chr12:11,537,950...11,627,563
JBrowse link
G Tshz1 teashirt zinc finger homeobox 1 increases expression ISO Metribolone results in increased expression of TSHZ1 mRNA CTD PMID:17010196 NCBI chr18:80,860,995...80,907,744
Ensembl chr18:80,862,372...80,865,584
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO Metribolone results in decreased expression of TUBB protein CTD PMID:17152098 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression ISO Metribolone results in decreased expression of TXNRD1 protein CTD PMID:17152098 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Uap1 UDP-N-acetylglucosamine pyrophosphorylase 1 increases expression ISO Metribolone results in increased expression of UAP1 protein CTD PMID:17152098 NCBI chr13:88,463,532...88,497,901
Ensembl chr13:88,463,532...88,497,901
JBrowse link
G Uba6 ubiquitin-like modifier activating enzyme 6 increases expression ISO Metribolone results in increased expression of UBA6 protein CTD PMID:17152098 NCBI chr14:23,507,628...23,571,446
Ensembl chr14:23,507,628...23,571,446
JBrowse link
G Ube2j1 ubiquitin-conjugating enzyme E2, J1 increases expression ISO Metribolone results in increased expression of UBE2J1 mRNA CTD PMID:16751804 NCBI chr 5:48,274,387...48,292,699
Ensembl chr 5:48,274,477...48,290,658
JBrowse link
G Ubl5 ubiquitin-like 5 affects splicing ISO Metribolone affects the splicing of UBL5 mRNA CTD PMID:17010196 NCBI chr 8:21,663,257...21,665,049
Ensembl chr 8:21,663,325...21,665,038
JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 decreases expression ISO Metribolone results in decreased expression of UFD1 protein CTD PMID:17152098 NCBI chr11:86,304,836...86,328,478
Ensembl chr11:86,304,815...86,328,469
JBrowse link
G Upf1 UPF1, RNA helicase and ATPase multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to UPF1 protein] CTD PMID:17220478 NCBI chr16:20,824,888...20,845,632
Ensembl chr16:20,824,864...20,845,243
JBrowse link
G Uqcc2 ubiquinol-cytochrome c reductase complex assembly factor 2 increases expression ISO Metribolone results in increased expression of UQCC2 mRNA CTD PMID:17010196 NCBI chr20:5,712,200...5,723,902
Ensembl chr20:5,712,203...5,723,902
JBrowse link
G Usp5 ubiquitin specific peptidase 5 affects localization ISO Metribolone affects the localization of USP5 protein CTD PMID:17440980 NCBI chr 4:157,332,735...157,347,803
Ensembl chr 4:157,332,740...157,347,803
JBrowse link
G Uxt ubiquitously-expressed, prefoldin-like chaperone multiple interactions
affects response to substance
ISO Metribolone promotes the reaction [UXT protein binds to ATR promoter]; Metribolone promotes the reaction [UXT protein binds to GSTE1 promoter]; Metribolone promotes the reaction [UXT protein binds to KLK3 promoter]; Metribolone promotes the reaction [UXT protein binds to NKX3-1 promoter]; UXT protein affects the reaction [Metribolone results in increased expression of BRIP1 mRNA]; UXT protein affects the reaction [Metribolone results in increased expression of KLK3 mRNA]; UXT protein affects the reaction [Metribolone results in increased expression of NKX3-1 mRNA]
UXT protein affects the susceptibility to Metribolone
CTD PMID:19318562 NCBI chr  X:1,275,402...1,287,781
Ensembl chr  X:1,275,612...1,287,512
JBrowse link
G Vcl vinculin increases expression ISO Metribolone results in increased expression of VCL protein CTD PMID:17152098 NCBI chr15:3,455,211...3,544,738
Ensembl chr15:3,455,211...3,544,702
JBrowse link
G Vcp valosin-containing protein multiple interactions
increases expression
ISO Metribolone promotes the reaction [NDRG1 protein binds to VCP protein]
Metribolone results in increased expression of VCP protein
CTD PMID:17152098 PMID:17220478 NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953
JBrowse link
G Vta1 vesicle trafficking 1 decreases expression ISO Metribolone results in decreased expression of VTA1 protein CTD PMID:17152098 NCBI chr 1:8,830,405...8,878,191
Ensembl chr 1:8,830,411...8,878,244
JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 increases expression ISO Metribolone results in increased expression of WARS1 protein CTD PMID:17152098 NCBI chr 6:132,771,026...132,802,262
Ensembl chr 6:132,771,021...132,802,210
JBrowse link
G Xpnpep1 X-prolyl aminopeptidase 1 increases expression ISO Metribolone results in increased expression of XPNPEP1 protein CTD PMID:17152098 NCBI chr 1:273,708,217...273,758,247
Ensembl chr 1:273,708,212...273,758,442
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 decreases expression ISO Metribolone results in decreased expression of XRCC5 protein CTD PMID:17152098 NCBI chr 9:79,659,275...79,748,050
Ensembl chr 9:79,659,251...79,748,078
JBrowse link
G Xrcc6 X-ray repair cross complementing 6 multiple interactions ISO Metribolone promotes the reaction [NDRG1 protein binds to XRCC6 protein] CTD PMID:17220478 NCBI chr 7:123,259,881...123,280,613
Ensembl chr 7:123,259,761...123,280,612
JBrowse link
G Xrn1 5'-3' exoribonuclease 1 increases expression
multiple interactions
ISO Metribolone results in increased expression of XRN1 protein
MIR204 mRNA inhibits the reaction [Metribolone results in increased expression of XRN1 protein]
CTD PMID:25797256 NCBI chr 8:103,774,125...103,883,563
Ensembl chr 8:103,774,358...103,878,899
JBrowse link
G Ythdf1 YTH N(6)-methyladenosine RNA binding protein 1 increases expression ISO Metribolone results in increased expression of YTHDF1 mRNA CTD PMID:17010196 NCBI chr 3:176,415,911...176,431,423
Ensembl chr 3:176,415,914...176,431,423
JBrowse link
G Zbtb10 zinc finger and BTB domain containing 10 increases expression ISO Metribolone results in increased expression of ZBTB10 mRNA CTD PMID:16751804 PMID:17010675 NCBI chr 2:94,692,939...94,730,976
Ensembl chr 2:94,692,939...94,730,978
JBrowse link
G Zdhhc2 zinc finger DHHC-type palmitoyltransferase 2 increases expression ISO Metribolone results in increased expression of ZDHHC2 mRNA CTD PMID:17010196 NCBI chr16:54,932,546...55,002,322
Ensembl chr16:54,934,056...55,002,322
JBrowse link
G Znhit3 zinc finger, HIT-type containing 3 multiple interactions ISO [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to ZNHIT3 protein modified form] CTD PMID:28751236 NCBI chr10:72,227,710...72,235,932
Ensembl chr10:72,228,222...72,235,888
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        molecular messenger 18275
          hormone 18027
            sex hormone 17908
              androgen 3939
                17beta-hydroxy-17-methylestra-4,9,11-trien-3-one 410
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      ketone 16171
                                        oxo steroid 9279
                                          3-oxo steroid 8809
                                            17beta-hydroxy-17-methylestra-4,9,11-trien-3-one 410
paths to the root