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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dye
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Accession:CHEBI:37958 term browser browse the term
Synonyms:related_synonym: Farbstoff;   Farbstoffe;   colorante;   colorantes;   dyes;   teinture;   teintures


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1,4-phenylenediamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 increases expression ISO 4-phenylenediamine results in increased expression of ABCC3 mRNA CTD PMID:16314067 NCBI chr11:94,343,295...94,393,017
Ensembl chr11:94,343,295...94,392,997
JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 increases activity
increases expression
ISO 4-phenylenediamine results in increased activity of AKR1C2 promoter
4-phenylenediamine results in increased expression of AKR1C2 mRNA
CTD PMID:20491607, PMID:21195160, PMID:25724174 NCBI chr13:4,574,075...4,586,543
Ensembl chr13:4,574,075...4,586,541
JBrowse link
G Anxa1 annexin A1 increases expression ISO 4-phenylenediamine results in increased expression of ANXA1 mRNA CTD PMID:16314067 NCBI chr19:20,373,434...20,390,671
Ensembl chr19:20,373,428...20,390,944
JBrowse link
G Aqp3 aquaporin 3 decreases expression ISO 4-phenylenediamine results in decreased expression of AQP3 mRNA CTD PMID:15140218 NCBI chr 4:41,092,724...41,098,183
Ensembl chr 4:41,092,722...41,098,183
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO 4-phenylenediamine results in increased expression of ATF3 mRNA CTD PMID:16314067, PMID:23999411, PMID:27965148 NCBI chr 1:191,170,296...191,183,333
Ensembl chr 1:191,170,296...191,218,039
JBrowse link
G Bach1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 multiple interactions ISO BACH1 mRNA promotes the reaction [4-phenylenediamine results in increased expression of HMOX1 mRNA] CTD PMID:26244607 NCBI chr16:87,698,954...87,733,346
Ensembl chr16:87,698,945...87,733,346
JBrowse link
G Casp1 caspase 1 multiple interactions
increases activity
ISO 4-phenylenediamine promotes the reaction [[NLRP12 protein binds to NLRP3 protein binds to CASP1 protein] which binds to PYCARD protein]
4-phenylenediamine results in increased activity of CASP1 protein
CTD PMID:31276767 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp3 caspase 3 increases activity ISO 4-phenylenediamine results in increased activity of CASP3 protein CTD PMID:26784575 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 increases secretion EXP 4-phenylenediamine results in increased secretion of CCL2 protein CTD PMID:22245253 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccl4 chemokine (C-C motif) ligand 4 increases expression ISO 4-phenylenediamine results in increased expression of CCL4 mRNA CTD PMID:20713136 NCBI chr11:83,648,624...83,664,683
Ensembl chr11:83,662,584...83,664,683
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 increases expression ISO 4-phenylenediamine results in increased expression of CCL5 mRNA CTD PMID:27585668 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518
JBrowse link
G Ccl7 chemokine (C-C motif) ligand 7 increases expression ISO 4-phenylenediamine results in increased expression of CCL7 mRNA CTD PMID:27585668 NCBI chr11:82,045,712...82,047,525
Ensembl chr11:82,045,712...82,047,525
JBrowse link
G Ccr2 chemokine (C-C motif) receptor 2 decreases expression ISO 4-phenylenediamine results in decreased expression of CCR2 mRNA CTD PMID:19371601 NCBI chr 9:124,101,918...124,109,140
Ensembl chr 9:124,101,950...124,113,557
JBrowse link
G Ccr6 chemokine (C-C motif) receptor 6 decreases expression EXP 4-phenylenediamine results in decreased expression of CCR6 protein CTD PMID:15924226 NCBI chr17:8,236,041...8,258,519
Ensembl chr17:8,236,043...8,257,141
JBrowse link
G Cd274 CD274 antigen increases expression ISO 4-phenylenediamine results in increased expression of CD274 protein CTD PMID:20488241 NCBI chr19:29,362,107...29,388,095
Ensembl chr19:29,367,455...29,388,095
JBrowse link
G Cd86 CD86 antigen multiple interactions
increases expression
ISO bisindolylmaleimide I inhibits the reaction [4-phenylenediamine results in increased expression of CD86 protein] CTD PMID:12423654, PMID:19033392, PMID:19665512, PMID:20488241, PMID:24136171 NCBI chr16:36,568,956...36,666,158
Ensembl chr16:36,603,869...36,666,081
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression ISO 4-phenylenediamine results in increased expression of CDKN1A mRNA CTD PMID:16314067 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Crem cAMP responsive element modulator increases expression ISO 4-phenylenediamine results in increased expression of CREM mRNA CTD PMID:19371601 NCBI chr18:3,266,354...3,337,773
Ensembl chr18:3,266,048...3,337,748
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) increases secretion EXP 4-phenylenediamine results in increased secretion of CSF2 protein CTD PMID:22245253 NCBI chr11:54,247,270...54,249,899
Ensembl chr11:54,247,271...54,249,667
JBrowse link
G Cxcl1 chemokine (C-X-C motif) ligand 1 increases expression ISO 4-phenylenediamine results in increased expression of CXCL1 mRNA CTD PMID:20713136 NCBI chr 5:90,891,245...90,893,121
Ensembl chr 5:90,891,241...90,893,115
JBrowse link
G Cxcl10 chemokine (C-X-C motif) ligand 10 decreases expression EXP 4-phenylenediamine results in decreased expression of CXCL10 mRNA CTD PMID:23445166 NCBI chr 5:92,346,638...92,348,889
Ensembl chr 5:92,346,638...92,348,889
JBrowse link
G Cxcl14 chemokine (C-X-C motif) ligand 14 decreases expression ISO 4-phenylenediamine results in decreased expression of CXCL14 protein CTD PMID:31734321 NCBI chr13:56,288,643...56,296,811
Ensembl chr13:56,288,643...56,296,551
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions
increases secretion
increases expression
ISO bisindolylmaleimide I affects the reaction [4-phenylenediamine results in increased expression of CXCL8 protein]; SB 203580 affects the reaction [4-phenylenediamine results in increased secretion of CXCL8 protein]
4-phenylenediamine results in increased expression of CXCL8 mRNA; 4-phenylenediamine results in increased expression of CXCL8 protein
CTD PMID:16099135, PMID:18494145, PMID:20491607, PMID:20713136, PMID:21920952, PMID:24136171, PMID:25617811, PMID:27965148, PMID:31734321 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 increases expression EXP 4-phenylenediamine results in increased expression of CXCL2 protein CTD PMID:23178550 NCBI chr 5:90,903,899...90,905,938
Ensembl chr 5:90,903,871...90,905,938
JBrowse link
G Cxcl3 chemokine (C-X-C motif) ligand 3 increases expression ISO 4-phenylenediamine results in increased expression of CXCL1 mRNA CTD PMID:20713136 NCBI chr 5:90,786,101...90,788,093
Ensembl chr 5:90,786,103...90,789,600
JBrowse link
G Cxcr4 chemokine (C-X-C motif) receptor 4 decreases expression EXP 4-phenylenediamine results in decreased expression of CXCR4 protein CTD PMID:15924226 NCBI chr 1:128,588,199...128,592,299
Ensembl chr 1:128,588,199...128,592,293
JBrowse link
G Cytip cytohesin 1 interacting protein increases expression ISO 4-phenylenediamine results in increased expression of CYTIP mRNA CTD PMID:19371601 NCBI chr 2:58,129,139...58,195,549
Ensembl chr 2:58,129,137...58,195,532
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO 4-phenylenediamine results in increased expression of DNAJB4 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr 3:152,181,580...152,210,432
Ensembl chr 3:152,178,511...152,210,302
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO 4-phenylenediamine results in increased expression of DUSP1 mRNA CTD PMID:16314067 NCBI chr17:26,505,591...26,508,472
Ensembl chr17:26,505,590...26,562,128
JBrowse link
G Fth1 ferritin heavy polypeptide 1 increases expression ISO 4-phenylenediamine results in increased expression of FTH1 mRNA CTD PMID:16314067 NCBI chr19:9,980,600...9,985,111
Ensembl chr19:9,980,598...9,985,098
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO 4-phenylenediamine results in increased expression of GCLM mRNA CTD PMID:16314067, PMID:23999411, PMID:27965148 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Gm40318 predicted gene, 40318 increases expression ISO 4-phenylenediamine results in increased expression of S100P mRNA CTD PMID:16314067 NCBI chr 5:36,762,504...36,767,419
Ensembl chr 5:36,762,617...36,766,695
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 increases metabolic processing ISO 4-phenylenediamine results in increased metabolism of GSTP1 protein CTD PMID:19469519 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Has1 hyaluronan synthase 1 increases expression ISO 4-phenylenediamine results in increased expression of HAS1 mRNA; 4-phenylenediamine results in increased expression of HAS1 protein CTD PMID:31226360 NCBI chr17:17,833,691...17,855,589
Ensembl chr17:17,843,323...17,855,205
JBrowse link
G Has2 hyaluronan synthase 2 increases expression ISO 4-phenylenediamine results in increased expression of HAS2 mRNA; 4-phenylenediamine results in increased expression of HAS2 protein CTD PMID:31226360 NCBI chr15:56,665,627...56,694,546
Ensembl chr15:56,665,627...56,694,539
JBrowse link
G Has3 hyaluronan synthase 3 increases expression ISO 4-phenylenediamine results in increased expression of HAS3 mRNA; 4-phenylenediamine results in increased expression of HAS3 protein CTD PMID:31226360 NCBI chr 8:106,870,242...106,882,902
Ensembl chr 8:106,870,242...106,884,566
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit increases expression ISO 4-phenylenediamine results in increased expression of HIF1A mRNA CTD PMID:16314067 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
4-phenylenediamine results in increased expression of HMOX1 mRNA
BACH1 mRNA promotes the reaction [4-phenylenediamine results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA promotes the reaction [4-phenylenediamine results in increased expression of HMOX1 mRNA]
CTD PMID:16314067, PMID:19033392, PMID:20491607, PMID:20713136, PMID:23445166, PMID:25724174, PMID:26244607 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hsph1 heat shock 105kDa/110kDa protein 1 increases expression ISO 4-phenylenediamine results in increased expression of HSPH1 mRNA CTD PMID:23999411 NCBI chr 5:149,616,843...149,636,498
Ensembl chr 5:149,614,287...149,636,376
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 increases expression ISO 4-phenylenediamine results in increased expression of HTATIP2 mRNA CTD PMID:16314067 NCBI chr 7:49,759,045...49,774,000
Ensembl chr 7:49,759,115...49,773,975
JBrowse link
G Hyal1 hyaluronoglucosaminidase 1 increases expression ISO 4-phenylenediamine results in increased expression of HYAL1 mRNA CTD PMID:31226360 NCBI chr 9:107,576,950...107,581,699
Ensembl chr 9:107,576,927...107,581,710
JBrowse link
G Ifng interferon gamma increases expression
increases secretion
EXP 4-phenylenediamine results in increased expression of IFNG mRNA
4-phenylenediamine results in increased secretion of IFNG protein
CTD PMID:11531941, PMID:22245253 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il10 interleukin 10 increases expression EXP 4-phenylenediamine results in increased expression of IL10 mRNA CTD PMID:11531941 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il17f interleukin 17F increases expression EXP 4-phenylenediamine results in increased expression of IL17F mRNA CTD PMID:23445166 NCBI chr 1:20,777,146...20,785,274
Ensembl chr 1:20,777,146...20,790,617
JBrowse link
G Il18 interleukin 18 increases expression
multiple interactions
ISO 4-phenylenediamine results in increased expression of IL18 protein
PRDM1 protein promotes the reaction [4-phenylenediamine results in increased expression of IL18 protein]
CTD PMID:23063874, PMID:27585668 NCBI chr 9:50,554,700...50,581,841
Ensembl chr 9:50,554,827...50,581,840
JBrowse link
G Il1a interleukin 1 alpha increases expression EXP 4-phenylenediamine results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il1b interleukin 1 beta increases expression ISO 4-phenylenediamine results in increased expression of IL1B mRNA CTD PMID:15140218 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il2 interleukin 2 increases secretion EXP 4-phenylenediamine results in increased secretion of IL2 protein CTD PMID:22245253 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il4 interleukin 4 increases expression
increases secretion
EXP 4-phenylenediamine results in increased expression of IL4 mRNA
4-phenylenediamine results in increased secretion of IL4 protein
CTD PMID:11531941, PMID:22245253 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Il6 interleukin 6 increases secretion EXP 4-phenylenediamine results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Lrp6 low density lipoprotein receptor-related protein 6 decreases phosphorylation ISO 4-phenylenediamine results in decreased phosphorylation of LRP6 protein CTD PMID:26784575 NCBI chr 6:134,446,476...134,566,913
Ensembl chr 6:134,446,476...134,566,965
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO 4-phenylenediamine results in increased phosphorylation of MAPK8 protein CTD PMID:23172806 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO 4-phenylenediamine results in increased phosphorylation of MAPK9 protein CTD PMID:23172806 NCBI chr11:49,846,728...49,886,421
Ensembl chr11:49,846,751...49,886,421
JBrowse link
G Me1 malic enzyme 1, NADP(+)-dependent, cytosolic increases expression ISO 4-phenylenediamine results in increased expression of ME1 mRNA CTD PMID:16314067 NCBI chr 9:86,581,363...86,695,914
Ensembl chr 9:86,581,371...86,695,953
JBrowse link
G Mlst8 MTOR associated protein, LST8 homolog (S. cerevisiae) decreases expression ISO 4-phenylenediamine results in decreased expression of MLST8 protein CTD PMID:26784575 NCBI chr17:24,473,550...24,479,114
Ensembl chr17:24,473,551...24,479,078
JBrowse link
G Mt2 metallothionein 2 increases expression ISO 4-phenylenediamine results in increased expression of MT2A mRNA CTD PMID:16314067 NCBI chr 8:94,172,618...94,173,567
Ensembl chr 8:94,172,664...94,173,568
JBrowse link
G Mtor mechanistic target of rapamycin kinase affects phosphorylation ISO 4-phenylenediamine affects the phosphorylation of MTOR protein CTD PMID:26784575 NCBI chr 4:148,448,582...148,557,685
Ensembl chr 4:148,448,611...148,557,683
JBrowse link
G Nat1 N-acetyl transferase 1 increases acetylation
multiple interactions
ISO NAT1 protein results in increased acetylation of 4-phenylenediamine
4-phenylenediamine results in decreased activity of and results in decreased expression of NAT1 protein
CTD PMID:15350687, PMID:20406859 NCBI chr 8:67,490,968...67,492,531
Ensembl chr 8:67,480,921...67,492,104
JBrowse link
G Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) affects response to substance ISO NAT2 gene polymorphism affects the susceptibility to 4-phenylenediamine CTD PMID:16533241 NCBI chr 8:67,494,875...67,502,644
Ensembl chr 8:67,494,858...67,502,584
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression
multiple interactions
ISO 4-phenylenediamine results in increased expression of NFE2L2 protein
NFE2L2 mRNA promotes the reaction [4-phenylenediamine results in increased expression of HMOX1 mRNA]
CTD PMID:19033392, PMID:26244607 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha decreases phosphorylation ISO 4-phenylenediamine results in decreased phosphorylation of NFKBIA protein CTD PMID:26784575 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Ninj1 ninjurin 1 increases expression ISO 4-phenylenediamine results in increased expression of NINJ1 mRNA CTD PMID:16314067 NCBI chr13:49,187,529...49,196,251
Ensembl chr13:49,187,485...49,196,244
JBrowse link
G Nlrp12 NLR family, pyrin domain containing 12 increases expression
multiple interactions
decreases expression
ISO 4-phenylenediamine results in increased expression of NLRP12 mRNA
4-phenylenediamine promotes the reaction [[NLRP12 protein binds to NLRP3 protein binds to CASP1 protein] which binds to PYCARD protein]
4-phenylenediamine results in decreased expression of NLRP12 protein
CTD PMID:27585668, PMID:31276767 NCBI chr 7:3,218,643...3,249,771
Ensembl chr 7:3,218,784...3,249,740
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression
multiple interactions
ISO 4-phenylenediamine results in increased expression of NLRP3 protein
4-phenylenediamine promotes the reaction [[NLRP12 protein binds to NLRP3 protein binds to CASP1 protein] which binds to PYCARD protein]
CTD PMID:31276767 NCBI chr11:59,541,569...59,566,955
Ensembl chr11:59,541,568...59,566,956
JBrowse link
G Nlrx1 NLR family member X1 increases expression ISO 4-phenylenediamine results in increased expression of NLRX1 mRNA CTD PMID:27585668 NCBI chr 9:44,252,713...44,268,599
Ensembl chr 9:44,252,717...44,268,599
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression EXP
ISO
4-phenylenediamine results in increased expression of NQO1 mRNA CTD PMID:16314067, PMID:19033392, PMID:23445166, PMID:25724174 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO 4-phenylenediamine results in increased expression of PGD mRNA CTD PMID:16314067 NCBI chr 4:149,149,991...149,166,705
Ensembl chr 4:149,149,991...149,166,771
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A increases mutagenesis ISO 4-phenylenediamine results in increased mutagenesis of PIGA gene CTD PMID:30439388 NCBI chr  X:164,419,780...164,433,916
Ensembl chr  X:164,419,787...164,433,916
JBrowse link
G Pir pirin increases expression ISO 4-phenylenediamine results in increased expression of PIR mRNA CTD PMID:16314067 NCBI chr  X:164,269,431...164,373,013
Ensembl chr  X:164,269,371...164,373,011
JBrowse link
G Plin2 perilipin 2 increases expression ISO 4-phenylenediamine results in increased expression of PLIN2 mRNA CTD PMID:16314067 NCBI chr 4:86,626,910...86,670,217
Ensembl chr 4:86,648,386...86,670,060
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO 4-phenylenediamine results in increased expression of PMAIP1 mRNA CTD PMID:16314067, PMID:20713136 NCBI chr18:66,458,604...66,465,558
Ensembl chr18:66,458,533...66,465,565
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression ISO 4-phenylenediamine results in increased expression of PPARG mRNA CTD PMID:16314067 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Prdm1 PR domain containing 1, with ZNF domain multiple interactions
increases expression
ISO BAY 11-7085 inhibits the reaction [4-phenylenediamine results in increased expression of PRDM1 mRNA]; BAY 11-7085 inhibits the reaction [4-phenylenediamine results in increased expression of PRDM1 protein]; PRDM1 protein promotes the reaction [4-phenylenediamine results in increased expression of IL18 protein]
4-phenylenediamine results in increased expression of PRDM1 mRNA; 4-phenylenediamine results in increased expression of PRDM1 protein
CTD PMID:27585668, PMID:31276767 NCBI chr10:44,437,174...44,528,558
Ensembl chr10:44,437,177...44,528,501
JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions EXP 4-phenylenediamine promotes the reaction [Gentamicins results in increased expression of PRDX3 protein] CTD PMID:23626763 NCBI chr19:60,864,066...60,874,538
Ensembl chr19:60,864,051...60,874,556
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO 4-phenylenediamine results in increased expression of PTGS1 mRNA CTD PMID:18571826 NCBI chr 2:36,216,742...36,258,593
Ensembl chr 2:36,230,426...36,252,272
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO 4-phenylenediamine results in increased expression of PTGS2 mRNA CTD PMID:18571826, PMID:19371601, PMID:20713136 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Pycard PYD and CARD domain containing increases expression
multiple interactions
ISO 4-phenylenediamine results in increased expression of PYCARD protein
4-phenylenediamine promotes the reaction [[NLRP12 protein binds to NLRP3 protein binds to CASP1 protein] which binds to PYCARD protein]
CTD PMID:31276767 NCBI chr 7:127,991,373...127,993,867
Ensembl chr 7:127,989,708...127,993,867
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) increases phosphorylation
multiple interactions
ISO 4-phenylenediamine results in increased phosphorylation of RELA protein
aristolochic acid I inhibits the reaction [4-phenylenediamine results in increased phosphorylation of RELA protein]; TLR4 protein promotes the reaction [4-phenylenediamine results in increased phosphorylation of RELA protein]
CTD PMID:31226360 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rgs1 regulator of G-protein signaling 1 increases expression ISO 4-phenylenediamine results in increased expression of RGS1 mRNA CTD PMID:20713136 NCBI chr 1:144,244,669...144,249,104
Ensembl chr 1:144,242,296...144,249,242
JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 decreases expression ISO 4-phenylenediamine results in decreased expression of RICTOR protein CTD PMID:26784575 NCBI chr15:6,708,349...6,800,401
Ensembl chr15:6,708,379...6,800,401
JBrowse link
G Rit1 Ras-like without CAAX 1 increases expression ISO 4-phenylenediamine results in increased expression of RIT1 mRNA CTD PMID:16314067 NCBI chr 3:88,716,842...88,731,048
Ensembl chr 3:88,716,838...88,731,049
JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 decreases expression ISO 4-phenylenediamine results in decreased expression of RPTOR protein CTD PMID:26784575 NCBI chr11:119,602,905...119,899,591
Ensembl chr11:119,602,905...119,899,576
JBrowse link
G Sis sucrase isomaltase (alpha-glucosidase) increases expression ISO 4-phenylenediamine results in increased expression of SI mRNA CTD PMID:16314067 NCBI chr 3:72,888,557...72,967,863
Ensembl chr 3:72,888,557...72,967,863
JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 decreases expression ISO 4-phenylenediamine results in decreased expression of SLAMF1 mRNA CTD PMID:20713136 NCBI chr 1:171,767,131...171,801,184
Ensembl chr 1:171,767,127...171,801,184
JBrowse link
G Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 increases expression ISO 4-phenylenediamine results in increased expression of SLC2A3 mRNA CTD PMID:19371601 NCBI chr 6:122,727,809...122,802,363
Ensembl chr 6:122,727,809...122,801,640
JBrowse link
G Spta1 spectrin alpha, erythrocytic 1 increases expression ISO 4-phenylenediamine results in increased expression of SPTA1 mRNA CTD PMID:16314067 NCBI chr 1:174,172,739...174,248,449
Ensembl chr 1:174,172,776...174,248,450
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
increases expression
ISO TLR4 protein promotes the reaction [4-phenylenediamine results in increased phosphorylation of RELA protein]
4-phenylenediamine results in increased expression of TLR4 mRNA; 4-phenylenediamine results in increased expression of TLR4 protein
CTD PMID:31226360 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284
JBrowse link
G Tnf tumor necrosis factor affects response to substance
increases secretion
ISO
EXP
TNF gene polymorphism affects the susceptibility to 4-phenylenediamine
4-phenylenediamine results in increased secretion of TNF protein
CTD PMID:18384449, PMID:22245253 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 increases expression ISO 4-phenylenediamine results in increased expression of TNFAIP3 mRNA CTD PMID:20713136 NCBI chr10:19,000,910...19,015,410
Ensembl chr10:19,000,910...19,015,657
JBrowse link
G Tnfaip6 tumor necrosis factor alpha induced protein 6 increases expression ISO 4-phenylenediamine results in increased expression of TNFAIP6 mRNA CTD PMID:20713136 NCBI chr 2:52,038,113...52,056,681
Ensembl chr 2:52,038,009...52,056,686
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression EXP 4-phenylenediamine results in increased expression of TXNRD1 mRNA CTD PMID:23445166 NCBI chr10:82,833,951...82,897,724
Ensembl chr10:82,833,951...82,897,712
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 4-phenylenediamine results in increased expression of VEGFA protein CTD PMID:9390328, PMID:25617811 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
2',7'-bis-(2-carboxyethyl)carboxyfluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 multiple interactions ISO Mefloquine inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] CTD PMID:16004972 NCBI chr14:118,482,692...118,707,856
Ensembl chr14:118,482,692...118,706,219
JBrowse link
G Abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 increases export
multiple interactions
ISO ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein
daidzein inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; hesperetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; naringenin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; Quercetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; resveratrol inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; Silymarin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]
CTD PMID:16156793 NCBI chr16:20,331,303...20,426,428
Ensembl chr16:20,331,303...20,426,394
JBrowse link
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 multiple interactions
decreases activity
ISO bisbenzimide ethoxide trihydrochloride inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
bisbenzimide ethoxide trihydrochloride results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A multiple interactions
increases transport
ISO
EXP
abamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride
abamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
CTD PMID:25865432 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 multiple interactions
increases transport
ISO
EXP
abamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride] CTD PMID:25865432 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) decreases abundance
decreases export
decreases activity
multiple interactions
increases export
increases transport
ISO ABCG2 protein results in decreased abundance of bisbenzimide ethoxide trihydrochloride
ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride
bisbenzimide ethoxide trihydrochloride results in decreased activity of ABCG2 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; [MYC protein results in increased expression of ABCG2 protein] which results in increased export of bisbenzimide ethoxide trihydrochloride; Cimetidine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Cyclosporine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; danofloxacin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Genistein inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Genistein promotes the reaction [ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride]; Methotrexate inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Nitrofurantoin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Reserpine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Tobacco Smoke Pollution inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; verlukast inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
CTD PMID:12869632, PMID:19239227, PMID:26850786, PMID:26907376, PMID:27450509, PMID:27475308 NCBI chr 6:58,584,491...58,692,451
Ensembl chr 6:58,584,523...58,695,676
JBrowse link
G Keap1 kelch-like ECH-associated protein 1 decreases export ISO KEAP1 protein results in decreased export of bisbenzimide ethoxide trihydrochloride CTD PMID:25841332 NCBI chr 9:21,229,730...21,239,332
Ensembl chr 9:21,229,730...21,239,361
JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO [MYC protein results in increased expression of ABCG2 protein] which results in increased export of bisbenzimide ethoxide trihydrochloride CTD PMID:19239227 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
2,6-dichloroindophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 BCL2-like 1 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in decreased expression of BCL2L1 mRNA CTD PMID:21034357 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Ccl4 chemokine (C-C motif) ligand 4 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CCL4 mRNA CTD PMID:21034357 NCBI chr11:83,648,624...83,664,683
Ensembl chr11:83,662,584...83,664,683
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CDKN1A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CDKN1A protein CTD PMID:21034357 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions ISO 2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; 2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]] CTD PMID:19635391 NCBI chr19:12,763,528...12,765,632
Ensembl chr19:12,763,660...12,765,632
JBrowse link
G Cryab crystallin, alpha B multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CRYAB mRNA CTD PMID:21034357 NCBI chr 9:50,745,951...50,756,636
Ensembl chr 9:50,751,325...50,756,636
JBrowse link
G Cxcl10 chemokine (C-X-C motif) ligand 10 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CXCL10 mRNA CTD PMID:21034357 NCBI chr 5:92,346,638...92,348,889
Ensembl chr 5:92,346,638...92,348,889
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of EGR1 mRNA CTD PMID:21034357 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of EPHX2 mRNA CTD PMID:21034357 NCBI chr14:66,084,372...66,124,522
Ensembl chr14:66,084,374...66,124,500
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of FASLG mRNA CTD PMID:21034357 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GADD45A mRNA CTD PMID:21034357 NCBI chr 6:67,035,096...67,037,407
Ensembl chr 6:67,035,096...67,037,457
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GDF15 mRNA CTD PMID:21034357 NCBI chr 8:70,629,393...70,632,470
Ensembl chr 8:70,629,393...70,632,456
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GSTM3 mRNA CTD PMID:21034357 NCBI chr 3:107,895,854...107,898,685
Ensembl chr 3:107,895,821...107,898,686
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HMOX1 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HMOX1 protein CTD PMID:21034357 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hspa1a heat shock protein 1A multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA1A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA1A protein CTD PMID:21034357 NCBI chr17:34,969,359...34,972,156
Ensembl chr17:34,969,190...34,972,156
JBrowse link
G Hspa2 heat shock protein 2 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA2 mRNA CTD PMID:21034357 NCBI chr12:76,403,812...76,406,938
Ensembl chr12:76,404,176...76,406,938
JBrowse link
G Lta lymphotoxin A multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of LTA mRNA CTD PMID:21034357 NCBI chr17:35,203,165...35,205,578
Ensembl chr17:35,203,165...35,205,351
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of NOS2 mRNA CTD PMID:21034357 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
increases reduction
increases response to substance
ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in decreased expression of BCL2L1 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CCL4 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CDKN1A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CDKN1A protein; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CRYAB mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CXCL10 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of EGR1 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of EPHX2 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of FASLG mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GADD45A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GDF15 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GSTM3 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HMOX1 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HMOX1 protein; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA1A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA1A protein; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA2 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA6 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA6 protein; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of LTA mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of NOS2 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of TNF mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased phosphorylation of TP53 protein; Carbamazepine inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; Diclofenac inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; Dicumarol inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; Mefenamic Acid inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; NQO1 protein inhibits the reaction [2,6-Dichloroindophenol results in decreased abundance of Glutathione]; NQO1 protein polymorphism promotes the reaction [2,6-Dichloroindophenol results in decreased abundance of Glutathione]; Tacrine inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]
NQO1 protein polymorphism results in increased susceptibility to 2,6-Dichloroindophenol
CTD PMID:21034357, PMID:29281794 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide quinone reductase 2 multiple interactions
increases reduction
ISO [NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of 2,6-Dichloroindophenol; [NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of 2,6-Dichloroindophenol; resveratrol inhibits the reaction [NQO2 protein results in increased reduction of 2,6-Dichloroindophenol]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of 2,6-Dichloroindophenol] CTD PMID:20399199, PMID:29281794 NCBI chr13:33,964,655...33,988,465
Ensembl chr13:33,964,687...33,988,443
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO 2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]] CTD PMID:19635391 NCBI chr 1:52,119,438...52,161,865
Ensembl chr 1:52,119,440...52,161,865
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO 2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]] CTD PMID:19635391 NCBI chr11:100,886,806...100,939,594
Ensembl chr11:100,885,098...100,939,540
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of TNF mRNA CTD PMID:21034357 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased phosphorylation of TP53 protein CTD PMID:21034357 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
2-nitro-p-phenylenediamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1b ATP-binding cassette, sub-family B (MDR/TAP), member 1B decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of ABCB1B mRNA CTD PMID:17070881 NCBI chr 5:8,798,147...8,866,314
Ensembl chr 5:8,798,147...8,866,315
JBrowse link
G Acmsd amino carboxymuconate semialdehyde decarboxylase decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of ACMSD mRNA CTD PMID:17070881 NCBI chr 1:127,729,413...127,767,564
Ensembl chr 1:127,729,413...127,767,978
JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of ACSL3 mRNA CTD PMID:17070881 NCBI chr 1:78,657,825...78,707,743
Ensembl chr 1:78,657,825...78,707,743
JBrowse link
G Aen apoptosis enhancing nuclease increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of AEN mRNA CTD PMID:17070881 NCBI chr 7:78,895,927...78,911,209
Ensembl chr 7:78,895,854...78,911,209
JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of ALDH1A1 mRNA CTD PMID:17070881 NCBI chr19:20,492,583...20,643,463
Ensembl chr19:20,492,715...20,643,465
JBrowse link
G Apoa2 apolipoprotein A-II decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of APOA2 mRNA CTD PMID:17070881 NCBI chr 1:171,221,564...171,226,379
Ensembl chr 1:171,225,054...171,226,379
JBrowse link
G Apoa4 apolipoprotein A-IV decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of APOA4 mRNA CTD PMID:17070881 NCBI chr 9:46,240,844...46,243,458
Ensembl chr 9:46,240,696...46,243,459
JBrowse link
G Apoc3 apolipoprotein C-III decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of APOC3 mRNA CTD PMID:17070881 NCBI chr 9:46,233,050...46,235,636
Ensembl chr 9:46,232,933...46,235,636
JBrowse link
G Atp6v1d ATPase, H+ transporting, lysosomal V1 subunit D increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of ATP6V1D mRNA CTD PMID:17070881 NCBI chr12:78,842,982...78,862,008
Ensembl chr12:78,840,725...78,861,638
JBrowse link
G Bax BCL2-associated X protein decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of BAX mRNA CTD PMID:17070881 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Btg2 BTG anti-proliferation factor 2 decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of BTG2 mRNA CTD PMID:17070881 NCBI chr 1:134,074,865...134,079,155
Ensembl chr 1:134,075,170...134,079,120
JBrowse link
G C7 complement component 7 decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of C7 mRNA CTD PMID:17070881 NCBI chr15:4,987,750...5,063,773
Ensembl chr15:4,988,762...5,063,740
JBrowse link
G Cblc Casitas B-lineage lymphoma c decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of CBLC mRNA CTD PMID:17070881 NCBI chr 7:19,779,718...19,796,809
Ensembl chr 7:19,778,881...19,796,809
JBrowse link
G Ccng1 cyclin G1 increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of CCNG1 mRNA CTD PMID:17070881 NCBI chr11:40,748,552...40,755,309
Ensembl chr11:40,748,552...40,755,311
JBrowse link
G Cd276 CD276 antigen increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of CD276 mRNA CTD PMID:17070881 NCBI chr 9:58,524,300...58,555,033
Ensembl chr 9:58,524,298...58,555,437
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of CDKN1A mRNA CTD PMID:17070881 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cpq carboxypeptidase Q decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of CPQ mRNA CTD PMID:17070881 NCBI chr15:33,083,129...33,594,552
Ensembl chr15:33,083,129...33,594,552
JBrowse link
G Cryab crystallin, alpha B increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of CRYAB mRNA CTD PMID:17070881 NCBI chr 9:50,745,951...50,756,636
Ensembl chr 9:50,751,325...50,756,636
JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of DDAH1 mRNA CTD PMID:17070881 NCBI chr 3:145,758,692...145,894,277
Ensembl chr 3:145,758,675...145,894,277
JBrowse link
G Epcam epithelial cell adhesion molecule increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of EPCAM mRNA CTD PMID:17070881 NCBI chr17:87,635,979...87,651,127
Ensembl chr17:87,635,979...87,651,129
JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of EPHX1 mRNA CTD PMID:17070881 NCBI chr 1:180,989,556...181,017,569
Ensembl chr 1:180,976,210...181,020,904
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of FAS mRNA CTD PMID:17070881 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fhit fragile histidine triad gene increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of FHIT mRNA CTD PMID:17070881 NCBI chr14:9,550,092...11,162,061
Ensembl chr14:9,550,092...11,162,035
JBrowse link
G Gria3 glutamate receptor, ionotropic, AMPA3 (alpha 3) increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of GRIA3 mRNA CTD PMID:17070881 NCBI chr  X:41,400,819...41,678,601
Ensembl chr  X:41,400,854...41,678,601
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of GSTM1 mRNA CTD PMID:17070881 NCBI chr 3:108,012,250...108,017,973
Ensembl chr 3:108,012,255...108,017,973
JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of HSD17B6 mRNA CTD PMID:17070881 NCBI chr10:127,990,931...128,007,648
Ensembl chr10:127,990,936...128,007,611
JBrowse link
G Il2ra interleukin 2 receptor, alpha chain decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of IL2RA mRNA CTD PMID:17070881 NCBI chr 2:11,642,792...11,693,194
Ensembl chr 2:11,642,807...11,693,193
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of MGMT mRNA CTD PMID:17070881 NCBI chr 7:136,894,463...137,128,193
Ensembl chr 7:136,894,614...137,130,266
JBrowse link
G Nupr1 nuclear protein transcription regulator 1 increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of NUPR1 mRNA CTD PMID:17070881 NCBI chr 7:126,623,246...126,625,470
Ensembl chr 7:126,623,249...126,630,861
JBrowse link
G Phlda3 pleckstrin homology like domain, family A, member 3 decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of PHLDA3 mRNA CTD PMID:17070881 NCBI chr 1:135,766,085...135,769,134
Ensembl chr 1:135,766,119...135,769,136
JBrowse link
G Rhobtb2 Rho-related BTB domain containing 2 increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of RHOBTB2 mRNA CTD PMID:17070881 NCBI chr14:69,784,990...69,824,847
Ensembl chr14:69,784,990...69,805,636
JBrowse link
G Serpina7 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of SERPINA7 mRNA CTD PMID:17070881 NCBI chr  X:139,079,249...139,085,236
Ensembl chr  X:139,079,257...139,085,236
JBrowse link
G Slc16a10 solute carrier family 16 (monocarboxylic acid transporters), member 10 decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of SLC16A10 mRNA CTD PMID:17070881 NCBI chr10:40,033,532...40,142,270
Ensembl chr10:40,033,532...40,142,258
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of SPINK1 mRNA CTD PMID:17070881 NCBI chr18:43,728,069...43,737,237
Ensembl chr18:43,728,082...43,737,557
JBrowse link
G Sugct succinyl-CoA glutarate-CoA transferase increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of SUGCT mRNA CTD PMID:17070881 NCBI chr13:16,857,472...17,694,795
Ensembl chr13:16,857,472...17,695,553
JBrowse link
G Sulf2 sulfatase 2 decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of SULF2 mRNA CTD PMID:17070881 NCBI chr 2:166,073,899...166,155,683
Ensembl chr 2:166,073,089...166,155,663
JBrowse link
G Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of SULT2A1 mRNA CTD PMID:17070881 NCBI chr 7:13,796,246...13,837,410
Ensembl chr 7:13,796,246...13,837,409
JBrowse link
G Zmat3 zinc finger matrin type 3 decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of ZMAT3 mRNA CTD PMID:17070881 NCBI chr 3:32,334,792...32,365,665
Ensembl chr 3:32,334,792...32,366,014
JBrowse link
3,4-dihydrocoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddit3 DNA-damage inducible transcript 3 affects expression EXP 3,4-dihydrocoumarin affects the expression of DDIT3 mRNA CTD PMID:22016648 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of DNAJA2 mRNA CTD PMID:22016648 NCBI chr 8:85,537,633...85,555,361
Ensembl chr 8:85,537,633...85,555,344
JBrowse link
G Egf epidermal growth factor increases expression EXP 3,4-dihydrocoumarin results in increased expression of EGF mRNA CTD PMID:22016648 NCBI chr 3:129,677,574...129,755,322
Ensembl chr 3:129,677,565...129,755,316
JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of EPHX1 mRNA CTD PMID:22016648 NCBI chr 1:180,989,556...181,017,569
Ensembl chr 1:180,976,210...181,020,904
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression EXP 3,4-dihydrocoumarin results in increased expression of HSD17B4 mRNA CTD PMID:22016648 NCBI chr18:50,128,201...50,196,270
Ensembl chr18:50,128,201...50,196,269
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of HSP90AB1 mRNA CTD PMID:22016648 NCBI chr17:45,567,778...45,573,261
Ensembl chr17:45,567,775...45,573,271
JBrowse link
G Hspa1a heat shock protein 1A increases expression EXP 3,4-dihydrocoumarin results in increased expression of HSPA1A mRNA CTD PMID:22016648 NCBI chr17:34,969,359...34,972,156
Ensembl chr17:34,969,190...34,972,156
JBrowse link
G Kap kidney androgen regulated protein decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of KAP mRNA CTD PMID:22016648 NCBI chr 6:133,849,855...133,853,667
Ensembl chr 6:133,849,851...133,853,762
JBrowse link
G Oat ornithine aminotransferase decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of OAT mRNA CTD PMID:22016648 NCBI chr 7:132,557,475...132,576,398
Ensembl chr 7:132,557,478...132,576,398
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of PCK1 mRNA CTD PMID:22016648 NCBI chr 2:173,153,073...173,159,274
Ensembl chr 2:173,153,048...173,159,273
JBrowse link
G Pon1 paraoxonase 1 affects metabolic processing ISO PON1 SNP affects the metabolism of 3,4-dihydrocoumarin CTD PMID:25027835 NCBI chr 6:5,168,090...5,193,987
Ensembl chr 6:5,168,090...5,193,946
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression EXP 3,4-dihydrocoumarin results in increased expression of PRDX1 mRNA CTD PMID:22016648 NCBI chr 4:116,685,599...116,700,000
Ensembl chr 4:116,685,544...116,700,822
JBrowse link
G Prdx3 peroxiredoxin 3 decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of PRDX3 mRNA CTD PMID:22016648 NCBI chr19:60,864,066...60,874,538
Ensembl chr19:60,864,051...60,874,556
JBrowse link
G Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of PSMB8 mRNA CTD PMID:22016648 NCBI chr17:34,198,195...34,201,454
Ensembl chr17:34,197,721...34,201,454
JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of PTPMT1 mRNA CTD PMID:22016648 NCBI chr 2:90,910,713...90,918,050
Ensembl chr 2:90,908,716...90,918,258
JBrowse link
G Rbp4 retinol binding protein 4, plasma decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of RBP4 mRNA CTD PMID:22016648 NCBI chr19:38,116,620...38,125,321
Ensembl chr19:38,116,629...38,125,281
JBrowse link
G Sod1 superoxide dismutase 1, soluble decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of SOD1 mRNA CTD PMID:22016648 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of TIMP2 mRNA CTD PMID:22016648 NCBI chr11:118,301,061...118,355,411
Ensembl chr11:118,301,069...118,355,740
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of TUBB5 mRNA CTD PMID:22016648 NCBI chr17:35,833,920...35,838,301
Ensembl chr17:35,833,921...35,838,306
JBrowse link
3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Alizarin Red S binds to ALB protein CTD PMID:18968587 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A decreases activity ISO thiazolyl blue results in decreased activity of ABCB1 protein CTD PMID:15451006 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Aco2 aconitase 2, mitochondrial multiple interactions EXP [Calcium results in increased activity of ACO2 protein] which results in increased reduction of thiazolyl blue; [Potassium deficiency results in decreased activity of ACO2 protein] which results in decreased reduction of thiazolyl blue CTD PMID:12548706 NCBI chr15:81,872,463...81,915,137
Ensembl chr15:81,872,309...81,915,133
JBrowse link
G Casp3 caspase 3 increases activity ISO thiazolyl blue results in increased activity of CASP3 protein CTD PMID:22401948 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp8 caspase 8 increases activity ISO thiazolyl blue results in increased activity of CASP8 protein CTD PMID:22401948 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide quinone reductase 2 multiple interactions
increases reduction
ISO resveratrol inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue] CTD PMID:29281794 NCBI chr13:33,964,655...33,988,465
Ensembl chr13:33,964,687...33,988,443
JBrowse link
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnmt1 DNA methyltransferase (cytosine-5) 1 decreases activity ISO lac dye results in decreased activity of DNMT1 protein CTD PMID:23839987 NCBI chr 9:20,907,206...20,959,888
Ensembl chr 9:20,907,209...20,959,888
JBrowse link
5(6)-carboxy-2',7'-dichlorofluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 affects transport
multiple interactions
increases export
increases transport
ISO ABCC2 protein affects the transport of 5(6)-carboxy-2',7'-dichlorofluorescein
4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein; Ascorbic Acid inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]]; Ascorbic Acid promotes the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Benzbromarone inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Calcium deficiency inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; cyanoginosin LR inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Cyclosporine inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; microcystin RR inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; microcystin-LF inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Probenecid inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog]; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Tobacco Smoke Pollution inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog]
ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein; ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog
[ABCC2 gene mutant form results in increased expression of ABCC3 protein] which results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein; ABCC2 gene mutant form inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]
CTD PMID:19326901, PMID:21240898, PMID:21341280, PMID:23562342, PMID:24907646, PMID:24909372, PMID:24973091, PMID:25862123, PMID:27450509, PMID:31348918 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 multiple interactions
increases transport
ISO [ABCC2 gene mutant form results in increased expression of ABCC3 protein] which results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein
Benzbromarone inhibits the reaction [ABCC3 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]
CTD PMID:24907646, PMID:31348918 NCBI chr11:94,343,295...94,393,017
Ensembl chr11:94,343,295...94,392,997
JBrowse link
G Abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 multiple interactions
increases transport
ISO Benzbromarone inhibits the reaction [ABCC5 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein] CTD PMID:31348918 NCBI chr16:20,331,303...20,426,428
Ensembl chr16:20,331,303...20,426,394
JBrowse link
5-carboxyfluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 multiple interactions
increases transport
ISO quercetin 3'-sulfate inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide analog inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein] CTD PMID:21244849 NCBI chr19:8,591,254...8,611,835
Ensembl chr19:8,591,254...8,611,835
JBrowse link
5-chloromethylfluorescein diacetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 multiple interactions ISO ABCC2 protein affects the transport of [5-chloromethylfluorescein co-treated with Glutathione] CTD PMID:16049127 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
6-carboxyfluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 increases export ISO ABCC1 protein results in increased export of 6-carboxyfluorescein CTD PMID:17940500 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 affects export
multiple interactions
ISO ABCC2 protein affects the export of 6-carboxyfluorescein
Probenecid inhibits the reaction [ABCC2 protein affects the export of 6-carboxyfluorescein]
CTD PMID:11477083 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 increases import
multiple interactions
ISO SLC22A6 protein results in increased import of 6-carboxyfluorescein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; glutaric acid promotes the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]
CTD PMID:28629854 NCBI chr19:8,617,996...8,628,299
Ensembl chr19:8,618,039...8,628,299
JBrowse link
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 increases import
multiple interactions
ISO SLC22A8 protein results in increased import of 6-carboxyfluorescein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; 2-amino-9H-pyrido(2,3-b)indole promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Cadmium Chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; glutaric acid promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; lead chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; sodium arsenate promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]
CTD PMID:28629854 NCBI chr19:8,591,254...8,611,835
Ensembl chr19:8,591,254...8,611,835
JBrowse link
9-aminoacridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase affects binding ISO Aminacrine binds to ACHE protein CTD PMID:31176713 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Bax BCL2-associated X protein increases response to substance ISO BAX protein results in increased susceptibility to Aminacrine CTD PMID:16177561 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G H2ax H2A.X variant histone decreases phosphorylation
multiple interactions
ISO Aminacrine results in decreased phosphorylation of H2AX protein
[Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]
CTD PMID:26928355 NCBI chr 9:44,334,715...44,336,077
Ensembl chr 9:44,334,694...44,336,077
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit increases activity ISO Aminacrine results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 multiple interactions ISO [Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; Aminacrine inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein] CTD PMID:26928355 NCBI chr17:35,841,495...35,859,670
Ensembl chr17:35,841,515...35,859,670
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Aminacrine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr10:89,454,234...89,533,645
Ensembl chr10:89,454,234...89,533,585
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Aminacrine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,584,189...12,628,489
Ensembl chr17:12,584,132...12,628,488
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Aminacrine results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
acid red 29 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO chromotrope 2R binds to ALB protein CTD PMID:19347248 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
acridine orange term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein increases response to substance ISO BAX protein results in increased susceptibility to Acridine Orange CTD PMID:16177561 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO [Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA CTD PMID:16814760 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Acridine Orange results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
acridine orange free base term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein increases response to substance ISO BAX protein results in increased susceptibility to Acridine Orange CTD PMID:16177561 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO [Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA CTD PMID:16814760 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Acridine Orange results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
alizarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO alizarin results in decreased activity of CYP1A1 protein CTD PMID:12379470 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO alizarin results in decreased activity of CYP1A2 protein CTD PMID:12379470 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO alizarin results in decreased activity of CYP1B1 protein CTD PMID:12379470 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 decreases activity ISO alizarin results in decreased activity of CYP2A6 protein CTD PMID:12379470 NCBI chr 7:26,307,192...26,315,088
Ensembl chr 7:26,307,169...26,315,088
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO alizarin results in decreased activity of CYP2E1 protein CTD PMID:12379470 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO alizarin binds to and results in increased activity of ESR1 protein CTD PMID:20707409 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 1:88,211,959...88,220,002
Ensembl chr 1:88,211,959...88,218,997
JBrowse link
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 increases glucuronidation ISO UGT1A10 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 1:88,055,411...88,220,002
Ensembl chr 1:88,055,388...88,219,004
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 1:88,070,779...88,220,002
Ensembl chr 1:88,070,800...88,218,997
JBrowse link
auramine O term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 increases expression
multiple interactions
ISO Benzophenoneidum results in increased expression of ALDH1A1 protein
ALDH1A1 protein promotes the reaction [Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein]
CTD PMID:28722353 NCBI chr19:20,492,583...20,643,463
Ensembl chr19:20,492,715...20,643,465
JBrowse link
G Ano6 anoctamin 6 increases expression ISO Benzophenoneidum results in increased expression of ANO6 protein CTD PMID:28722353 NCBI chr15:95,790,843...95,975,472
Ensembl chr15:95,790,843...95,974,751
JBrowse link
G Araf Araf proto-oncogene, serine/threonine kinase increases expression ISO Benzophenoneidum results in increased expression of ARAF protein CTD PMID:28722353 NCBI chr  X:20,797,707...20,860,521
Ensembl chr  X:20,797,814...20,860,519
JBrowse link
G Atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 increases expression ISO Benzophenoneidum results in increased expression of ATP6AP2 protein CTD PMID:28722353 NCBI chr  X:12,587,759...12,617,051
Ensembl chr  X:12,587,801...12,617,049
JBrowse link
G Ccdc22 coiled-coil domain containing 22 increases expression ISO Benzophenoneidum results in increased expression of CCDC22 protein CTD PMID:28722353 NCBI chr  X:7,593,809...7,605,420
Ensembl chr  X:7,593,809...7,605,517
JBrowse link
G Ccdc39 coiled-coil domain containing 39 increases expression ISO Benzophenoneidum results in increased expression of CCDC39 protein CTD PMID:28722353 NCBI chr 3:33,810,757...33,844,325
Ensembl chr 3:33,812,362...33,844,310
JBrowse link
G Cd44 CD44 antigen increases expression ISO Benzophenoneidum results in increased expression of CD44 protein CTD PMID:28722353 NCBI chr 2:102,811,141...102,901,669
Ensembl chr 2:102,811,141...102,901,665
JBrowse link
G Chtf18 CTF18, chromosome transmission fidelity factor 18 increases expression ISO Benzophenoneidum results in increased expression of CHTF18 protein CTD PMID:28722353 NCBI chr17:25,719,030...25,727,434
Ensembl chr17:25,718,926...25,727,419
JBrowse link
G Commd1 COMM domain containing 1 increases expression ISO Benzophenoneidum results in increased expression of COMMD1 protein CTD PMID:28722353 NCBI chr11:22,899,728...22,984,539
Ensembl chr11:22,896,136...22,982,382
JBrowse link
G Cops7b COP9 signalosome subunit 7B increases expression ISO Benzophenoneidum results in increased expression of COPS7B protein CTD PMID:28722353 NCBI chr 1:86,582,646...86,606,828
Ensembl chr 1:86,582,904...86,609,375
JBrowse link
G Cul3 cullin 3 increases expression ISO Benzophenoneidum results in increased expression of CUL3 protein CTD PMID:28722353 NCBI chr 1:80,264,923...80,340,690
Ensembl chr 1:80,264,923...80,340,480
JBrowse link
G Eif4g3 eukaryotic translation initiation factor 4 gamma, 3 increases expression ISO Benzophenoneidum results in increased expression of EIF4G3 protein CTD PMID:28722353 NCBI chr 4:137,991,779...138,207,086
Ensembl chr 4:137,993,022...138,208,508
JBrowse link
G Fastkd2 FAST kinase domains 2 increases expression ISO Benzophenoneidum results in increased expression of FASTKD2 protein CTD PMID:28722353 NCBI chr 1:63,730,599...63,753,385
Ensembl chr 1:63,730,614...63,754,655
JBrowse link
G Hook3 hook microtubule tethering protein 3 increases expression ISO Benzophenoneidum results in increased expression of HOOK3 protein CTD PMID:28722353 NCBI chr 8:26,021,421...26,119,618
Ensembl chr 8:26,021,421...26,119,224
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 increases expression ISO Benzophenoneidum results in increased expression of HSD17B7 protein CTD PMID:28722353 NCBI chr 1:169,949,535...169,969,242
Ensembl chr 1:169,949,535...169,969,241
JBrowse link
G Htt huntingtin increases expression ISO Benzophenoneidum results in increased expression of HTT protein CTD PMID:28722353 NCBI chr 5:34,761,721...34,912,534
Ensembl chr 5:34,761,740...34,912,534
JBrowse link
G Iqgap3 IQ motif containing GTPase activating protein 3 increases expression ISO Benzophenoneidum results in increased expression of IQGAP3 protein CTD PMID:28722353 NCBI chr 3:88,082,002...88,121,048
Ensembl chr 3:88,081,971...88,121,048
JBrowse link
G Kifap3 kinesin-associated protein 3 increases expression ISO Benzophenoneidum results in increased expression of KIFAP3 protein CTD PMID:28722353 NCBI chr 1:163,762,138...163,917,107
Ensembl chr 1:163,779,583...163,917,109
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO ALDH1A1 protein promotes the reaction [Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein]; Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein CTD PMID:28722353 NCBI chr 8:121,590,438...121,598,760
Ensembl chr 8:121,590,361...121,598,760
JBrowse link
G Map2k4 mitogen-activated protein kinase kinase 4 increases expression ISO Benzophenoneidum results in increased expression of MAP2K4 protein CTD PMID:28722353 NCBI chr11:65,688,244...65,788,359
Ensembl chr11:65,688,243...65,788,297
JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 increases expression ISO Benzophenoneidum results in increased expression of MBD3 protein CTD PMID:28722353 NCBI chr10:80,392,539...80,399,531
Ensembl chr10:80,392,539...80,399,550
JBrowse link
G Noa1 nitric oxide associated 1 increases expression ISO Benzophenoneidum results in increased expression of NOA1 protein CTD PMID:28722353 NCBI chr 5:77,294,169...77,310,413
Ensembl chr 5:77,294,182...77,310,084
JBrowse link
G Nup62 nucleoporin 62 increases expression ISO Benzophenoneidum results in increased expression of NUP62 protein CTD PMID:28722353 NCBI chr 7:44,816,088...44,831,836
Ensembl chr 7:44,816,088...44,830,812
JBrowse link
G Plcg1 phospholipase C, gamma 1 increases expression ISO Benzophenoneidum results in increased expression of PLCG1 protein CTD PMID:28722353 NCBI chr 2:160,731,310...160,775,760
Ensembl chr 2:160,731,300...160,775,760
JBrowse link
G Ppp4r1 protein phosphatase 4, regulatory subunit 1 increases expression ISO Benzophenoneidum results in increased expression of PPP4R1 protein CTD PMID:28722353 NCBI chr17:65,782,543...65,841,926
Ensembl chr17:65,782,573...65,841,926
JBrowse link
G Prim2 DNA primase, p58 subunit increases expression ISO Benzophenoneidum results in increased expression of PRIM2 protein CTD PMID:28722353 NCBI chr 1:33,453,808...33,669,808
Ensembl chr 1:33,453,810...33,669,795
JBrowse link
G Prom1 prominin 1 increases expression ISO Benzophenoneidum results in increased expression of PROM1 protein CTD PMID:28722353 NCBI chr 5:43,993,621...44,102,047
Ensembl chr 5:43,993,620...44,102,032
JBrowse link
G Prorp protein only RNase P catalytic subunit increases expression ISO Benzophenoneidum results in increased expression of PRORP protein CTD PMID:28722353 NCBI chr12:55,302,637...55,382,492
Ensembl chr12:55,299,577...55,382,533
JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 (soluble) increases expression ISO Benzophenoneidum results in increased expression of SHMT1 protein CTD PMID:28722353 NCBI chr11:60,788,897...60,811,265
Ensembl chr11:60,788,104...60,811,718
JBrowse link
G Srsf11 serine and arginine-rich splicing factor 11 increases expression ISO Benzophenoneidum results in increased expression of SRSF11 protein CTD PMID:28722353 NCBI chr 3:158,010,915...158,036,667
Ensembl chr 3:158,010,473...158,036,639
JBrowse link
G Tbc1d15 TBC1 domain family, member 15 increases expression ISO Benzophenoneidum results in increased expression of TBC1D15 protein CTD PMID:28722353 NCBI chr10:115,197,871...115,251,493
Ensembl chr10:115,197,872...115,251,467
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Benzophenoneidum results in increased expression of TFAM protein CTD PMID:28722353 NCBI chr10:71,225,468...71,238,328
Ensembl chr10:71,225,464...71,238,280
JBrowse link
G Usp24 ubiquitin specific peptidase 24 increases expression ISO Benzophenoneidum results in increased expression of USP24 protein CTD PMID:28722353 NCBI chr 4:106,315,980...106,446,613
Ensembl chr 4:106,316,213...106,441,322
JBrowse link
G Washc5 WASH complex subunit 5 increases expression ISO Benzophenoneidum results in increased expression of WASHC5 protein CTD PMID:28722353 NCBI chr15:59,331,863...59,374,194
Ensembl chr15:59,331,997...59,374,167
JBrowse link
aurintricarboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lig1 ligase I, DNA, ATP-dependent decreases activity ISO Aurintricarboxylic Acid results in decreased activity of LIG1 protein CTD PMID:15134906 NCBI chr 7:13,277,175...13,311,426
Ensembl chr 7:13,277,283...13,311,433
JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 decreases activity ISO Aurintricarboxylic Acid results in decreased activity of OGG1 protein CTD PMID:26218629 NCBI chr 6:113,326,972...113,334,877
Ensembl chr 6:113,326,972...113,335,068
JBrowse link
azure B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta (A4) precursor protein multiple interactions ISO [Azure B affects the cleavage of APP protein] which results in decreased secretion of APP protein modified form; Azure B results in decreased expression of and affects the cleavage of APP protein CTD PMID:30500345 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 decreases activity ISO Azure B results in decreased activity of BACE1 protein CTD PMID:30500345 NCBI chr 9:45,838,545...45,862,484
Ensembl chr 9:45,838,580...45,864,399
JBrowse link
Bandrowski's base term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b10 aldo-keto reductase family 1, member B10 (aldose reductase) increases expression ISO Bandrowski's base results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 6:34,384,247...34,396,949
Ensembl chr 6:34,384,218...34,396,950
JBrowse link
G Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) increases expression ISO Bandrowski's base results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 6:34,303,930...34,317,489
Ensembl chr 6:34,302,434...34,317,478
JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 increases expression ISO Bandrowski's base results in increased expression of AKR1C3 mRNA CTD PMID:20566472 NCBI chr13:4,132,615...4,150,646
Ensembl chr13:4,132,615...4,150,654
JBrowse link
G Cat catalase increases expression ISO Bandrowski's base results in increased expression of CAT mRNA CTD PMID:20566472 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccl17 chemokine (C-C motif) ligand 17 affects expression ISO Bandrowski's base affects the expression of CCL17 mRNA CTD PMID:18202158 NCBI chr 8:94,809,380...94,812,038
Ensembl chr 8:94,810,453...94,812,036
JBrowse link
G Ccl22 chemokine (C-C motif) ligand 22 affects expression ISO Bandrowski's base affects the expression of CCL22 mRNA CTD PMID:18202158 NCBI chr 8:94,745,684...94,751,388
Ensembl chr 8:94,745,590...94,751,699
JBrowse link
G Ccl4 chemokine (C-C motif) ligand 4 affects expression ISO Bandrowski's base affects the expression of CCL4 mRNA CTD PMID:18202158 NCBI chr11:83,648,624...83,664,683
Ensembl chr11:83,662,584...83,664,683
JBrowse link
G Ccr7 chemokine (C-C motif) receptor 7 affects expression
increases expression
ISO Bandrowski's base affects the expression of CCR7 mRNA
Bandrowski's base results in increased expression of CCR7 protein
CTD PMID:18202158, PMID:19665512 NCBI chr11:99,144,199...99,155,077
Ensembl chr11:99,144,196...99,155,077
JBrowse link
G Cd80 CD80 antigen increases expression ISO Bandrowski's base results in increased expression of CD80 protein CTD PMID:31958493 NCBI chr16:38,457,430...38,495,958
Ensembl chr16:38,455,561...38,496,335
JBrowse link
G Cd86 CD86 antigen affects expression
increases expression
ISO Bandrowski's base affects the expression of CD86 mRNA
Bandrowski's base results in increased expression of CD86 protein
CTD PMID:18202158, PMID:19665512, PMID:21742781, PMID:31958493 NCBI chr16:36,568,956...36,666,158
Ensembl chr16:36,603,869...36,666,081
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 affects expression ISO Bandrowski's base affects the expression of CXCL8 mRNA CTD PMID:18202158 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcr4 chemokine (C-X-C motif) receptor 4 affects expression ISO Bandrowski's base affects the expression of CXCR4 mRNA CTD PMID:18202158 NCBI chr 1:128,588,199...128,592,299
Ensembl chr 1:128,588,199...128,592,293
JBrowse link
G Fech ferrochelatase increases expression ISO Bandrowski's base results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:64,456,542...64,489,098
Ensembl chr18:64,452,914...64,490,251
JBrowse link
G Ftl1 ferritin light polypeptide 1 increases expression ISO Bandrowski's base results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr 7:45,457,944...45,459,886
Ensembl chr 7:45,457,944...45,459,884
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked increases expression ISO Bandrowski's base results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Bandrowski's base results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO Bandrowski's base results in increased expression of GCLM mRNA CTD PMID:20566472 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO Bandrowski's base results in increased expression of GPX3 mRNA CTD PMID:20566472 NCBI chr11:54,902,854...54,910,387
Ensembl chr11:54,902,453...54,910,377
JBrowse link
G Gsr glutathione reductase increases expression ISO Bandrowski's base results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Bandrowski's base results in increased expression of HMOX1 mRNA CTD PMID:20566472 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
affects expression
ISO Bandrowski's base results in increased expression of ICAM1 protein
Bandrowski's base affects the expression of ICAM1 mRNA
CTD PMID:18202158, PMID:21742781 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) increases expression ISO Bandrowski's base results in increased expression of MAFF mRNA CTD PMID:20566472 NCBI chr15:79,346,621...79,359,078
Ensembl chr15:79,346,621...79,359,076
JBrowse link
G Mafg v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) increases expression ISO Bandrowski's base results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr11:120,625,117...120,634,955
Ensembl chr11:120,625,117...120,633,600
JBrowse link
G Mafk v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) increases expression ISO Bandrowski's base results in increased expression of MAFK mRNA CTD PMID:20566472 NCBI chr 5:139,791,536...139,802,653
Ensembl chr 5:139,791,513...139,802,653
JBrowse link
G Me1 malic enzyme 1, NADP(+)-dependent, cytosolic increases expression ISO Bandrowski's base results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 9:86,581,363...86,695,914
Ensembl chr 9:86,581,371...86,695,953
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO Bandrowski's base results in increased expression of MGST1 mRNA CTD PMID:20566472 NCBI chr 6:138,140,527...138,156,755
Ensembl chr 6:138,140,316...138,156,755
JBrowse link
G Mt1 metallothionein 1 increases expression ISO Bandrowski's base results in increased expression of MT1X mRNA CTD PMID:20566472 NCBI chr 8:94,178,883...94,180,327
Ensembl chr 8:94,179,082...94,180,327
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO Bandrowski's base results in increased expression of NQO1 mRNA CTD PMID:20566472 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO Bandrowski's base results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 4:149,149,991...149,166,705
Ensembl chr 4:149,149,991...149,166,771
JBrowse link
G Ppia peptidylprolyl isomerase A affects expression ISO Bandrowski's base affects the expression of PPIA mRNA CTD PMID:18202158 NCBI chr11:6,415,867...6,419,817
Ensembl chr11:6,415,443...6,419,817
JBrowse link
G Prkcb protein kinase C, beta increases expression ISO Bandrowski's base results in increased expression of PRKCB protein CTD PMID:31958493 NCBI chr 7:122,289,104...122,634,402
Ensembl chr 7:122,288,751...122,634,402
JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO Bandrowski's base results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119
JBrowse link
G Sod1 superoxide dismutase 1, soluble increases expression ISO Bandrowski's base results in increased expression of SOD1 mRNA CTD PMID:20566472 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial increases expression ISO Bandrowski's base results in increased expression of SOD2 mRNA CTD PMID:20566472 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Sod3 superoxide dismutase 3, extracellular increases expression ISO Bandrowski's base results in increased expression of SOD3 mRNA CTD PMID:20566472 NCBI chr 5:52,363,804...52,369,738
Ensembl chr 5:52,363,791...52,371,418
JBrowse link
G Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) increases expression ISO Bandrowski's base results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr 2:152,105,524...152,111,376
Ensembl chr 2:152,105,516...152,111,376
JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a affects expression ISO Bandrowski's base affects the expression of TNFRSF1A mRNA CTD PMID:18202158 NCBI chr 6:125,349,723...125,362,483
Ensembl chr 6:125,349,362...125,362,484
JBrowse link
G Txn2 thioredoxin 2 increases expression ISO Bandrowski's base results in increased expression of TXN2 mRNA CTD PMID:20566472 NCBI chr15:77,915,051...77,928,994
Ensembl chr15:77,915,047...77,929,006
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Bandrowski's base results in increased expression of TXNRD1 mRNA CTD PMID:20566472 NCBI chr10:82,833,951...82,897,724
Ensembl chr10:82,833,951...82,897,712
JBrowse link
G Txnrd2 thioredoxin reductase 2 increases expression ISO Bandrowski's base results in increased expression of TXNRD2 mRNA CTD PMID:20566472 NCBI chr16:18,426,417...18,479,073
Ensembl chr16:18,426,384...18,479,073
JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B increases expression ISO Bandrowski's base results in increased expression of UGT1A6 mRNA CTD PMID:20566472 NCBI chr 1:88,103,257...88,218,998
Ensembl chr 1:88,103,252...88,219,003
JBrowse link
brazilein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd1 cyclin D1 decreases expression ISO brazilein results in decreased expression of CCND1 mRNA; brazilein results in decreased expression of CCND1 protein CTD PMID:23948132 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 decreases expression ISO brazilein results in decreased expression of CTNNB1 protein CTD PMID:23948132 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO brazilein results in decreased expression of GSK3B protein modified form CTD PMID:23948132 NCBI chr16:38,089,001...38,246,084
Ensembl chr16:38,089,001...38,246,084
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO brazilein promotes the reaction [SB 203580 results in decreased expression of and results in decreased activity of MMP2 protein]; brazilein promotes the reaction [wortmannin results in decreased expression of and results in decreased activity of MMP2 protein]; brazilein results in decreased expression of and results in decreased activity of MMP2 protein; SB 203580 promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]; wortmannin promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]
brazilein results in decreased expression of MMP2 mRNA
CTD PMID:23707804 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO brazilein results in decreased expression of and results in decreased phosphorylation of NFKBIA protein CTD PMID:23707804 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) decreases expression ISO brazilein results in decreased expression of RELA protein CTD PMID:23707804 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
brazilin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein increases expression ISO brazilin results in increased expression of BAX protein CTD PMID:28063998 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO brazilin results in decreased expression of BCL2 protein CTD PMID:28063998 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [brazilin results in increased expression of BECN1 protein]; BECN1 inhibits the reaction [brazilin results in increased activity of CASP3 protein]; BECN1 inhibits the reaction [brazilin results in increased expression of PARP1 protein modified form]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 mRNA]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 protein]
brazilin results in increased expression of BECN1 mRNA; brazilin results in increased expression of BECN1 protein
CTD PMID:28063998 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Acetylcysteine promotes the reaction [brazilin results in increased activity of CASP3 protein]; bafilomycin A1 promotes the reaction [brazilin results in increased activity of CASP3 protein]; BECN1 inhibits the reaction [brazilin results in increased activity of CASP3 protein] CTD PMID:28063998 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases expression
multiple interactions
ISO brazilin results in increased expression of PARP1 protein modified form
bafilomycin A1 promotes the reaction [brazilin results in increased expression of PARP1 protein modified form]; BECN1 inhibits the reaction [brazilin results in increased expression of PARP1 protein modified form]
CTD PMID:28063998 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO RELA protein promotes the reaction [brazilin results in decreased expression of SQSTM1 protein]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 mRNA]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 protein] CTD PMID:28063998 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [brazilin results in decreased expression of SQSTM1 protein]; RELA protein promotes the reaction [brazilin results in decreased expression of SQSTM1 protein] CTD PMID:28063998 NCBI chr11:50,200,152...50,210,820
Ensembl chr11:50,199,366...50,210,827
JBrowse link
brilliant green term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO brilliant green inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,584,189...12,628,489
Ensembl chr17:12,584,132...12,628,488
JBrowse link
bromocresol purple term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Bromcresol Purple binds to and results in decreased activity of NR1I2 protein CTD PMID:20869355 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824
JBrowse link
bromosulfophthalein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 affects transport ISO ABCB4 protein affects the transport of Sulfobromophthalein CTD PMID:15304119 NCBI chr 5:8,893,614...8,959,226
Ensembl chr 5:8,893,717...8,959,231
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 affects export ISO ABCC2 protein affects the export of Sulfobromophthalein CTD PMID:16046661 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Akr1c20 aldo-keto reductase family 1, member C20 decreases activity EXP Sulfobromophthalein results in decreased activity of AKR1C20 protein CTD PMID:16508162 NCBI chr13:4,486,856...4,523,354
Ensembl chr13:4,486,849...4,523,345
JBrowse link
G Cck cholecystokinin multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of CCK protein modified form] CTD PMID:25106415 NCBI chr 9:121,489,824...121,495,694
Ensembl chr 9:121,489,824...121,495,694
JBrowse link
G Gsta3 glutathione S-transferase, alpha 3 decreases activity
multiple interactions
ISO Sulfobromophthalein results in decreased activity of GSTA3 protein
Sulfobromophthalein binds to [GSTA3 protein co-treated with GSTA1 protein]
CTD PMID:3783048, PMID:8968379 NCBI chr 1:21,240,565...21,265,575
Ensembl chr 1:21,240,589...21,265,661
JBrowse link
G Gstm2 glutathione S-transferase, mu 2 decreases activity ISO Sulfobromophthalein results in decreased activity of GSTM2 protein CTD PMID:8968379 NCBI chr 3:107,981,702...107,986,420
Ensembl chr 3:107,981,702...107,986,453
JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO Sulfobromophthalein inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:18031729 NCBI chr 5:16,553,495...16,619,439
Ensembl chr 5:16,553,495...16,620,152
JBrowse link
G Ifng interferon gamma multiple interactions EXP Sulfobromophthalein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il12b interleukin 12b multiple interactions EXP Sulfobromophthalein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr11:44,400,063...44,414,677
Ensembl chr11:44,400,063...44,414,033
JBrowse link
G Keap1 kelch-like ECH-associated protein 1 decreases glutathionylation
decreases transport
EXP KEAP1 protein results in decreased glutathionylation of Sulfobromophthalein
KEAP1 protein results in decreased transport of Sulfobromophthalein
CTD PMID:19246623 NCBI chr 9:21,229,730...21,239,332
Ensembl chr 9:21,229,730...21,239,361
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects abundance
increases transport
increases glutathionylation
EXP NFE2L2 protein affects the abundance of Sulfobromophthalein
NFE2L2 protein results in increased transport of Sulfobromophthalein
NFE2L2 protein results in increased glutathionylation of Sulfobromophthalein
CTD PMID:19246623 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC10A1 protein results in increased uptake of Taurocholic Acid] CTD PMID:25106415 NCBI chr12:80,953,185...80,968,705
Ensembl chr12:80,953,183...80,968,705
JBrowse link
G Slc16a2 solute carrier family 16 (monocarboxylic acid transporters), member 2 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine] CTD PMID:28119167 NCBI chr  X:103,697,414...103,821,988
Ensembl chr  X:103,697,414...103,821,983
JBrowse link
G Slc19a1 solute carrier family 19 (folate transporter), member 1 multiple interactions
decreases activity
ISO Sulfobromophthalein inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]
Sulfobromophthalein results in decreased activity of SLC19A1 protein
CTD PMID:14612385 NCBI chr10:77,032,269...77,050,432
Ensembl chr10:77,032,241...77,061,002
JBrowse link
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:11602689 NCBI chr19:8,617,996...8,628,299
Ensembl chr19:8,618,039...8,628,299
JBrowse link
G Slc22a7 solute carrier family 22 (organic anion transporter), member 7 multiple interactions EXP Sulfobromophthalein inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates] CTD PMID:12065749 NCBI chr17:46,432,185...46,438,477
Ensembl chr17:46,432,183...46,438,457
JBrowse link
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate] CTD PMID:10224140 NCBI chr19:8,591,254...8,611,835
Ensembl chr19:8,591,254...8,611,835
JBrowse link
G Slc46a1 solute carrier family 46, member 1 multiple interactions
decreases activity
ISO Sulfobromophthalein inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]
Sulfobromophthalein results in decreased activity of SLC46A1 protein
CTD PMID:17475902, PMID:18174275 NCBI chr11:78,465,701...78,471,945
Ensembl chr11:78,465,697...78,472,059
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLCO1A2 protein results in increased uptake of Quercetin] CTD PMID:24947867 NCBI chr 6:141,805,438...141,856,284
Ensembl chr 6:141,805,440...141,856,199
JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 affects import
increases import
increases uptake
increases response to substance
multiple interactions
ISO SLCO1B3 protein affects the import of Sulfobromophthalein
SLCO1B3 protein results in increased import of Sulfobromophthalein
SLCO1B3 protein results in increased uptake of Sulfobromophthalein
SLCO1B3 protein results in increased susceptibility to Sulfobromophthalein
Apigenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Budesonide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Clarithromycin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Cyclosporine inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; glimepiride affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; kaempferol inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; naringenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; naringin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Nateglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Pioglitazone affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Pravastatin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Quercetin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Rutin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased import of cyanoginosin LR]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of (5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of CCK protein modified form]
CTD PMID:16046661, PMID:17369605, PMID:20171238, PMID:21430235, PMID:21661758, PMID:22394605, PMID:23121773, PMID:25106415, PMID:26134461 NCBI chr 6:141,629,452...141,686,646
Ensembl chr 6:141,629,518...141,686,646
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 affects import
decreases activity
multiple interactions
increases uptake
ISO SLCO2B1 protein affects the import of Sulfobromophthalein
Sulfobromophthalein results in decreased activity of SLCO2B1 protein
Budesonide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Cyclosporine inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; glimepiride inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Nateglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Pioglitazone affects the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Pravastatin inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Rifampin inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased import of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]
CTD PMID:16046661, PMID:21430235, PMID:23121773, PMID:25106415, PMID:27450509, PMID:31364238 NCBI chr 7:99,657,804...99,711,340
Ensembl chr 7:99,657,804...99,711,340
JBrowse link
bromothymol blue term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Bromthymol Blue binds to and results in increased activity of NR1I2 protein CTD PMID:20869355 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Bromthymol Blue binds to and results in decreased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr 1:171,213,934...171,218,845
Ensembl chr 1:171,213,970...171,220,701
JBrowse link
C3-thiacarbocyanine cation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Dithiazanine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 5:24,319,589...24,351,684
Ensembl chr 5:24,319,589...24,351,604
JBrowse link
calcein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A multiple interactions
increases secretion
increases export
ISO
EXP
[carvedilol results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; [Verapamil results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; Beclomethasone inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; desisobutyrylciclesonide inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Miconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Mometasone Furoate inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Troleandomycin inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of fluorexon]
Amiodarone inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Clotrimazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Cyclosporine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Miconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Reserpine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Troleandomycin inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]
CTD PMID:10571255, PMID:12235267, PMID:16442095 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 affects export
increases export
increases import
affects transport
multiple interactions
ISO
EXP
ABCC1 protein affects the export of fluorexon
ABCC1 protein results in increased export of fluorexon
ABCC1 protein results in increased import of fluorexon
ABCC1 protein affects the transport of fluorexon
Mefloquine inhibits the reaction [ABCC1 protein affects the export of fluorexon]; nobiletin promotes the reaction [ABCC1 protein results in increased import of fluorexon]; Quercetin inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; robinetin inhibits the reaction [ABCC1 protein affects the export of fluorexon]; Silymarin inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein affects the export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; Vincristine inhibits the reaction [ABCC1 protein affects the transport of fluorexon]
CTD PMID:10685512, PMID:15670588, PMID:16004972, PMID:16156793, PMID:18955043, PMID:26454883 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 affects export
increases abundance
multiple interactions
affects transport
ISO ABCC2 protein affects the export of fluorexon
ABCC2 protein alternative form results in increased abundance of fluorexon
robinetin inhibits the reaction [ABCC2 protein affects the export of fluorexon]
ABCC2 protein affects the transport of fluorexon
CTD PMID:15670588, PMID:15848949, PMID:22027652 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Abcc6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 affects transport ISO ABCC6 affects the transport of fluorexon CTD PMID:14667841 NCBI chr 7:45,974,110...46,030,491
Ensembl chr 7:45,967,555...46,030,302
JBrowse link
calcein am term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 affects export
multiple interactions
EXP ABCB11 protein affects the export of calcein AM
ditekiren inhibits the reaction [ABCB11 protein affects the export of calcein AM]
CTD PMID:10617675 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A increases transport
increases export
multiple interactions
increases activity
affects export
increases secretion
ISO ABCB1 protein results in increased transport of calcein AM
ABCB1 protein results in increased export of calcein AM
ABCB1A protein promotes the reaction [Emodin results in increased export of calcein AM]
2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [Endosulfan co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [phosalone co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [Verapamil binds to and results in decreased activity of ABCB1 protein] inhibits the reaction [sodium arsenite promotes the reaction [ABCB1 protein results in increased secretion of calcein AM]]; ABCB1 protein affects the reaction [Mifepristone results in decreased transport of calcein AM]; ABCB1 protein affects the reaction [zosuquidar trihydrochloride results in decreased transport of calcein AM]; Atorvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; chlorpyrifos-methyl affects the reaction [ABCB1 protein results in increased transport of calcein AM]; Cyclosporine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; deoxynivalenol inhibits the reaction [valspodar inhibits the reaction [ABCB1 protein results in increased export of calcein AM]]; Diazinon inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Diazinon promotes the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Endosulfan inhibits the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Endosulfan promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; fenoxycarb inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; fenvalerate inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; phosalone inhibits the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; phosalone inhibits the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; propiconazole inhibits the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole promotes the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Reserpine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; Simvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; sodium arsenite promotes the reaction [ABCB1 protein results in increased secretion of calcein AM]; valspodar inhibits the reaction [ABCB1 protein results in increased export of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Verapamil promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]
calcein AM results in increased activity of ABCB1 protein mutant form
CTD PMID:10617675, PMID:12711602, PMID:15616150, PMID:16121039, PMID:19223659, PMID:19549930, PMID:21783720, PMID:29174985, PMID:30217652 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 increases transport
multiple interactions
ISO ABCC1 protein results in increased transport of calcein AM
[ABCC1 protein results in increased susceptibility to Silver Nitrate] which results in decreased export of calcein AM; [ABCC1 protein results in increased susceptibility to Silver] which results in decreased export of calcein AM; [MYC protein results in increased expression of ABCC1 protein] which results in increased export of calcein AM; verlukast inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]; zearalenol metabolite inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]
CTD PMID:19239227, PMID:19647055, PMID:27376922 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 affects transport
multiple interactions
increases transport
increases export
ISO ABCC2 protein affects the transport of calcein AM
Atorvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Simvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]
[MYC protein results in increased expression of ABCC2 protein] which results in increased export of calcein AM; Atorvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; montelukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; Simvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; zearalenol inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]
CTD PMID:15210835, PMID:15616150, PMID:19239227, PMID:19647055, PMID:19952419 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 affects transport
multiple interactions
increases transport
ISO ABCC3 protein affects the transport of calcein AM
Dexamethasone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Glutathione promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Hydrocortisone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Prednisone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; verlukast inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]; zearalenol inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]
CTD PMID:15210835, PMID:15979871, PMID:19647055 NCBI chr11:94,343,295...94,393,017
Ensembl chr11:94,343,295...94,392,997
JBrowse link
G Abcc4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 multiple interactions ISO Glutathione promotes the reaction [ABCC4 protein affects the transport of calcein AM] CTD PMID:15210835 NCBI chr14:118,482,692...118,707,856
Ensembl chr14:118,482,692...118,706,219
JBrowse link
G Abcc6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 multiple interactions ISO Glutathione promotes the reaction [ABCC6 protein affects the transport of calcein AM] CTD PMID:15210835 NCBI chr 7:45,974,110...46,030,491
Ensembl chr 7:45,967,555...46,030,302
JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO [MYC protein results in increased expression of ABCC1 protein] which results in increased export of calcein AM; [MYC protein results in increased expression of ABCC2 protein] which results in increased export of calcein AM CTD PMID:19239227 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
cascade blue term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slco2b1 solute carrier organic anion transporter family, member 2b1 increases uptake
multiple interactions
ISO SLCO2B1 protein results in increased uptake of Cascade Blue
Bleomycin inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Capecitabine inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Docetaxel inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Etoposide inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Irinotecan inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Methotrexate inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Tamoxifen inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Teniposide inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Thiotepa inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]
CTD PMID:30863990 NCBI chr 7:99,657,804...99,711,340
Ensembl chr 7:99,657,804...99,711,340
JBrowse link
clofazimine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 decreases activity ISO Clofazimine results in decreased activity of ABCB11 protein CTD PMID:20829430, PMID:23956101 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616
JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha increases expression ISO Clofazimine results in increased expression of ACACA mRNA CTD PMID:31393584 NCBI chr11:84,129,635...84,401,651
Ensembl chr11:84,129,672...84,401,651
JBrowse link
G Cebpa CCAAT/enhancer binding protein (C/EBP), alpha increases expression ISO Clofazimine results in increased expression of CEBPA protein CTD PMID:31393584 NCBI chr 7:35,119,293...35,121,928
Ensembl chr 7:35,119,293...35,121,928
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 decreases expression ISO Clofazimine results in decreased expression of DGAT1 mRNA CTD PMID:31393584 NCBI chr15:76,502,012...76,512,021
Ensembl chr15:76,502,015...76,511,953
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) increases expression ISO Clofazimine results in increased expression of FAS mRNA CTD PMID:31393584 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO Clofazimine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Clofazimine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 5:24,319,589...24,351,684
Ensembl chr 5:24,319,589...24,351,604
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression ISO Clofazimine results in increased expression of PPARG mRNA; Clofazimine results in increased expression of PPARG protein CTD PMID:31393584 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO Clofazimine results in increased expression of SREBF1 mRNA CTD PMID:31393584 NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581
JBrowse link
G Zfp423 zinc finger protein 423 increases expression ISO Clofazimine results in increased expression of ZFP423 mRNA CTD PMID:31393584 NCBI chr 8:87,661,810...87,962,053
Ensembl chr 8:87,661,810...87,959,595
JBrowse link
coumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aass aminoadipate-semialdehyde synthase decreases expression ISO coumarin results in decreased expression of AASS mRNA CTD PMID:18480146 NCBI chr 6:23,072,173...23,132,986
Ensembl chr 6:23,072,173...23,132,986
JBrowse link
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 affects expression ISO coumarin affects the expression of ABCB11 mRNA CTD PMID:16963487 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 increases expression ISO coumarin results in increased expression of ABCC3 mRNA CTD PMID:18480146 NCBI chr11:94,343,295...94,393,017
Ensembl chr11:94,343,295...94,392,997
JBrowse link
G Acaa1a acetyl-Coenzyme A acyltransferase 1A increases expression ISO coumarin results in increased expression of ACAA1 mRNA CTD PMID:18480146 NCBI chr 9:119,341,028...119,350,296
Ensembl chr 9:119,339,676...119,350,299
JBrowse link
G Acaa2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) affects expression ISO coumarin affects the expression of ACAA2 mRNA CTD PMID:16963487 NCBI chr18:74,779,212...74,806,207
Ensembl chr18:74,779,197...74,806,208
JBrowse link
G Ache acetylcholinesterase multiple interactions EXP coumarin inhibits the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; coumarin inhibits the reaction [haloxon results in increased phosphorylation of ACHE protein]; coumarin inhibits the reaction [Paraoxon results in increased phosphorylation of ACHE protein] CTD PMID:10421444 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Acly ATP citrate lyase affects expression ISO coumarin affects the expression of ACLY mRNA CTD PMID:16963487 NCBI chr11:100,476,352...100,528,000
Ensembl chr11:100,476,353...100,528,000
JBrowse link
G Aco1 aconitase 1 affects expression ISO coumarin affects the expression of ACO1 mRNA CTD PMID:16963487 NCBI chr 4:40,143,265...40,199,009
Ensembl chr 4:40,143,081...40,198,338
JBrowse link
G Acot4 acyl-CoA thioesterase 4 increases expression ISO coumarin results in increased expression of ACOT4 mRNA CTD PMID:18480146 NCBI chr12:84,037,254...84,044,723
Ensembl chr12:84,038,379...84,048,601
JBrowse link
G Acsm1 acyl-CoA synthetase medium-chain family member 1 increases expression EXP coumarin results in increased expression of ACSM1 mRNA CTD PMID:17311802 NCBI chr 7:119,617,757...119,662,515
Ensembl chr 7:119,607,026...119,662,515
JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 decreases expression ISO coumarin analog results in decreased expression of AIFM1 mRNA CTD PMID:32578917 NCBI chr  X:48,474,944...48,513,563
Ensembl chr  X:48,474,944...48,513,563
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases expression ISO coumarin results in increased expression of AKR1B8 mRNA CTD PMID:18480146 NCBI chr 6:34,354,146...34,368,461
Ensembl chr 6:34,354,119...34,368,463
JBrowse link
G Akr1c6 aldo-keto reductase family 1, member C6 decreases expression ISO coumarin results in decreased expression of AKR1C6 mRNA CTD PMID:18480146 NCBI chr13:4,434,311...4,457,530
Ensembl chr13:4,434,306...4,457,877
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 affects expression ISO coumarin affects the expression of AKR1D1 mRNA CTD PMID:16963487 NCBI chr 6:37,529,978...37,574,921
Ensembl chr 6:37,530,173...37,568,815
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO coumarin analog results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:32578917 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 increases expression ISO coumarin results in increased expression of ALDH1A1 mRNA CTD PMID:18480146 NCBI chr19:20,492,583...20,643,463
Ensembl chr19:20,492,715...20,643,465
JBrowse link
G Alox5 arachidonate 5-lipoxygenase increases expression ISO coumarin results in increased expression of ALOX5 mRNA CTD PMID:18480146 NCBI chr 6:116,410,071...116,461,178
Ensembl chr 6:116,410,077...116,461,178
JBrowse link
G Anxa7 annexin A7 increases expression ISO coumarin results in increased expression of ANXA7 mRNA CTD PMID:18480146 NCBI chr14:20,455,261...20,480,133
Ensembl chr14:20,455,260...20,480,133
JBrowse link
G Apbb3 amyloid beta (A4) precursor protein-binding, family B, member 3 decreases expression ISO coumarin results in decreased expression of APBB3 mRNA CTD PMID:18480146 NCBI chr18:36,671,154...36,679,366
Ensembl chr18:36,671,154...36,679,366
JBrowse link
G Apcs serum amyloid P-component decreases expression ISO coumarin results in decreased expression of APCS mRNA CTD PMID:18480146 NCBI chr 1:172,893,961...172,895,054
Ensembl chr 1:172,893,961...172,895,041
JBrowse link
G Arg1 arginase, liver affects expression ISO coumarin affects the expression of ARG1 mRNA CTD PMID:16963487 NCBI chr10:24,915,207...24,927,470
Ensembl chr10:24,915,221...24,927,484
JBrowse link
G Asns asparagine synthetase increases expression ISO coumarin results in increased expression of ASNS mRNA CTD PMID:18480146 NCBI chr 6:7,675,165...7,693,209
Ensembl chr 6:7,675,169...7,693,254
JBrowse link
G Atpif1 ATPase inhibitory factor 1 increases expression ISO coumarin results in increased expression of ATPIF1 mRNA CTD PMID:18480146 NCBI chr 4:132,530,555...132,535,450
Ensembl chr 4:132,530,555...132,533,659
JBrowse link
G Atrn attractin decreases expression ISO coumarin results in decreased expression of ATRN mRNA CTD PMID:18480146 NCBI chr 2:130,906,430...131,030,333
Ensembl chr 2:130,906,495...131,030,333
JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression ISO coumarin results in decreased expression of AVPR1A mRNA CTD PMID:18480146 NCBI chr10:122,448,499...122,453,453
Ensembl chr10:122,448,499...122,453,452
JBrowse link
G Azgp1 alpha-2-glycoprotein 1, zinc affects expression ISO coumarin affects the expression of AZGP1 mRNA CTD PMID:16963487 NCBI chr 5:137,981,521...137,990,233
Ensembl chr 5:137,981,520...137,990,233
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO coumarin analog results in increased expression of BAD mRNA CTD PMID:32578917 NCBI chr19:6,941,861...6,951,905
Ensembl chr19:6,941,861...6,951,899
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO coumarin analog results in increased expression of BAK1 protein CTD PMID:31199928 NCBI chr17:27,019,812...27,028,627
Ensembl chr17:27,019,810...27,029,009
JBrowse link
G Bax BCL2-associated X protein increases expression ISO coumarin analog results in increased expression of BAX mRNA; coumarin results in increased expression of BAX protein CTD PMID:15964220, PMID:32578917 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bbc3 BCL2 binding component 3 increases expression ISO coumarin analog results in increased expression of BBC3 protein CTD PMID:31199928 NCBI chr 7:16,308,398...16,318,334
Ensembl chr 7:16,308,393...16,318,205
JBrowse link
G Bbox1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase) decreases expression ISO coumarin results in decreased expression of BBOX1 mRNA CTD PMID:18480146 NCBI chr 2:110,264,056...110,314,813
Ensembl chr 2:110,262,697...110,314,560
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO coumarin analog results in decreased expression of BCL2 mRNA; coumarin results in decreased expression of BCL2 protein CTD PMID:15964220, PMID:32578917 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 increases expression ISO coumarin results in increased expression of BHLHA15 mRNA CTD PMID:18480146 NCBI chr 5:144,190,286...144,194,441
Ensembl chr 5:144,190,286...144,194,441
JBrowse link
G Bhmt betaine-homocysteine methyltransferase decreases expression
affects expression
ISO coumarin results in decreased expression of BHMT mRNA
coumarin affects the expression of BHMT mRNA
CTD PMID:16963487, PMID:18480146 NCBI chr13:93,616,891...93,637,758
Ensembl chr13:93,616,675...93,637,961
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO coumarin analog results in increased expression of BID mRNA CTD PMID:32578917 NCBI chr 6:120,893,119...120,917,062
Ensembl chr 6:120,891,930...120,916,853
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO coumarin analog results in decreased expression of BIRC5 mRNA CTD PMID:32578917 NCBI chr11:117,849,237...117,855,743
Ensembl chr11:117,849,251...117,855,743
JBrowse link
G Capn1 calpain 1 decreases expression ISO coumarin analog results in decreased expression of CAPN1 mRNA CTD PMID:32578917 NCBI chr19:5,988,545...6,015,825
Ensembl chr19:5,988,545...6,015,897
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO coumarin results in decreased activity of CA1 protein CTD PMID:22077347 NCBI chr 3:14,766,214...14,808,365
Ensembl chr 3:14,766,216...14,808,368
JBrowse link
G Car2 carbonic anhydrase 2 increases expression
decreases activity
ISO coumarin results in increased expression of CA2 mRNA
coumarin results in decreased activity of CA2 protein
CTD PMID:18480146, PMID:22077347 NCBI chr 3:14,886,269...14,900,770
Ensembl chr 3:14,886,273...14,900,770
JBrowse link
G Car3 carbonic anhydrase 3 decreases expression ISO coumarin results in decreased expression of CA3 mRNA CTD PMID:18480146 NCBI chr 3:14,863,538...14,872,381
Ensembl chr 3:14,863,512...14,872,523
JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
ISO coumarin analog results in increased expression of CASP3 mRNA
coumarin analog results in increased cleavage of CASP3 protein
CTD PMID:32578917 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp8 caspase 8 increases expression ISO coumarin analog results in increased expression of CASP8 mRNA CTD PMID:32578917 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 increases expression ISO coumarin analog results in increased expression of CASP9 mRNA CTD PMID:32578917 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO coumarin inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased activity of CAT protein]
coumarin analog results in decreased activity of CAT protein
CTD PMID:21630391, PMID:32578917 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cbr1 carbonyl reductase 1 increases expression ISO coumarin results in increased expression of CBR1 mRNA CTD PMID:18480146 NCBI chr16:93,607,837...93,610,349
Ensembl chr16:93,605,853...93,610,505
JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO coumarin results in decreased expression of CCNB2 mRNA CTD PMID:18480146 NCBI chr 9:70,407,689...70,421,554
Ensembl chr 9:70,407,692...70,421,547
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO coumarin analog results in decreased expression of CCND1 mRNA CTD PMID:32578917 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Ccne1 cyclin E1 increases expression
decreases expression
ISO coumarin results in increased expression of CCNE1 mRNA
coumarin analog results in decreased expression of CCNE1 mRNA
CTD PMID:18480146, PMID:32578917 NCBI chr 7:38,097,984...38,107,490
Ensembl chr 7:38,097,984...38,107,534
JBrowse link
G Ccne2 cyclin E2 increases expression ISO coumarin results in increased expression of CCNE2 mRNA CTD PMID:18480146 NCBI chr 4:11,190,433...11,204,779
Ensembl chr 4:11,191,351...11,204,779
JBrowse link
G Cdh1 cadherin 1 increases expression ISO coumarin analog results in increased expression of CDH1 mRNA; coumarin analog results in increased expression of CDH1 protein CTD PMID:32578917 NCBI chr 8:106,603,350...106,670,247
Ensembl chr 8:106,603,351...106,670,246
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO coumarin analog results in decreased expression of CDH2 mRNA CTD PMID:32578917 NCBI chr18:16,588,877...16,809,246
Ensembl chr18:16,588,877...16,809,246
JBrowse link
G Cdk2 cyclin-dependent kinase 2 decreases expression ISO coumarin analog results in decreased expression of CDK2 mRNA CTD PMID:32578917 NCBI chr10:128,697,938...128,705,051
Ensembl chr10:128,697,939...128,705,031
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO coumarin analog results in decreased expression of CDK4 mRNA CTD PMID:32578917 NCBI chr10:127,063,535...127,067,288
Ensembl chr10:127,063,534...127,067,920
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression ISO coumarin analog results in increased expression of CDKN1A mRNA CTD PMID:32578917 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO coumarin results in decreased expression of CDKN3 mRNA CTD PMID:18480146 NCBI chr14:46,760,461...46,771,530
Ensembl chr14:46,760,541...46,771,669
JBrowse link
G Cdo1 cysteine dioxygenase 1, cytosolic affects expression ISO coumarin affects the expression of CDO1 mRNA CTD PMID:16963487 NCBI chr18:46,713,193...46,728,502
Ensembl chr18:46,713,193...46,728,395
JBrowse link
G Ces1d carboxylesterase 1D increases expression EXP coumarin results in increased expression of CES1 mRNA CTD PMID:17311802 NCBI chr 8:93,166,072...93,197,804
Ensembl chr 8:93,166,068...93,197,838
JBrowse link
G Cisd3 CDGSH iron sulfur domain 3 increases expression ISO coumarin results in increased expression of CISD3 mRNA CTD PMID:18480146 NCBI chr11:97,685,465...97,688,625
Ensembl chr11:97,685,826...97,688,621
JBrowse link
G Cldn3 claudin 3 decreases expression ISO coumarin analog results in decreased expression of CLDN3 mRNA CTD PMID:32578917 NCBI chr 5:134,986,214...134,987,476
Ensembl chr 5:134,986,214...134,987,472
JBrowse link
G Cldn4 claudin 4 decreases expression ISO coumarin analog results in decreased expression of CLDN4 mRNA CTD PMID:32578917 NCBI chr 5:134,945,123...134,946,934
Ensembl chr 5:134,945,119...134,946,934
JBrowse link
G Coq6 coenzyme Q6 monooxygenase increases expression ISO coumarin results in increased expression of COQ6 mRNA CTD PMID:18480146 NCBI chr12:84,361,756...84,373,796
Ensembl chr12:84,361,657...84,373,796
JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 increases expression ISO coumarin results in increased expression of CREG mRNA CTD PMID:18480146 NCBI chr 1:165,763,758...165,775,309
Ensembl chr 1:165,763,746...165,775,308
JBrowse link
G Creld2 cysteine-rich with EGF-like domains 2 increases expression ISO coumarin results in increased expression of CRELD2 mRNA CTD PMID:18480146 NCBI chr15:88,819,646...88,826,681
Ensembl chr15:88,819,646...88,826,683
JBrowse link
G Cryab crystallin, alpha B decreases expression ISO coumarin results in decreased expression of CRYAB mRNA CTD PMID:18480146 NCBI chr 9:50,745,951...50,756,636
Ensembl chr 9:50,751,325...50,756,636
JBrowse link
G Cryl1 crystallin, lambda 1 increases expression ISO coumarin results in increased expression of CRYL1 mRNA CTD PMID:18480146 NCBI chr14:57,275,034...57,398,483
Ensembl chr14:57,274,993...57,398,529
JBrowse link
G Csad cysteine sulfinic acid decarboxylase decreases expression ISO coumarin results in decreased expression of CSAD mRNA CTD PMID:18480146 NCBI chr15:102,176,997...102,205,052
Ensembl chr15:102,176,999...102,204,724
JBrowse link
G Csrp1 cysteine and glycine-rich protein 1 decreases expression ISO coumarin results in decreased expression of CSRP1 mRNA CTD PMID:18480146 NCBI chr 1:135,720,063...135,752,229
Ensembl chr 1:135,720,061...135,752,232
JBrowse link
G Ctf1 cardiotrophin 1 increases expression ISO coumarin results in increased expression of CTF1 mRNA CTD PMID:18480146 NCBI chr 7:127,712,676...127,718,188
Ensembl chr 7:127,712,736...127,718,192
JBrowse link
G Cth cystathionase (cystathionine gamma-lyase) affects expression ISO coumarin affects the expression of CTH mRNA CTD PMID:16963487 NCBI chr 3:157,894,248...157,925,081
Ensembl chr 3:157,894,248...157,925,077
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 decreases expression ISO coumarin analog results in decreased expression of CTNNB1 mRNA CTD PMID:32578917 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Ctsb cathepsin B increases expression ISO coumarin analog results in increased expression of CTSB mRNA CTD PMID:32578917 NCBI chr14:63,122,462...63,145,923
Ensembl chr14:63,122,462...63,145,923
JBrowse link
G Cxcl12 chemokine (C-X-C motif) ligand 12 decreases expression ISO coumarin results in decreased expression of CXCL12 mRNA CTD PMID:18480146 NCBI chr 6:117,168,535...117,181,368
Ensembl chr 6:117,168,535...117,181,367
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 decreases expression ISO coumarin analog results in decreased expression of CXCL8 mRNA CTD PMID:32578917 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cyb561 cytochrome b-561 increases expression ISO coumarin results in increased expression of CYB561 mRNA CTD PMID:18480146 NCBI chr11:105,933,702...105,945,019
Ensembl chr11:105,933,702...105,953,336
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO coumarin analog results in increased expression of CYCS mRNA CTD PMID:32578917 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression
affects expression
ISO coumarin results in decreased expression of CYP1A2 mRNA
coumarin affects the expression of CYP1A2 mRNA
CTD PMID:16963487, PMID:18480146 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp2a22 cytochrome P450, family 2, subfamily a, polypeptide 22 increases hydroxylation ISO CYP2A6 protein results in increased hydroxylation of coumarin CTD PMID:12919726 NCBI chr 7:26,931,631...26,939,413
Ensembl chr 7:26,931,631...26,939,384
JBrowse link
G Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 decreases activity
increases hydroxylation
affects binding
multiple interactions
increases metabolic processing
affects metabolic processing
decreases metabolic processing
ISO coumarin results in decreased activity of CYP2A6 protein
CYP2A6 protein polymorphism results in increased hydroxylation of coumarin; CYP2A6 protein results in increased hydroxylation of coumarin
coumarin binds to CYP2A6 protein
[5-chlorotryptamine analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [5-methyltryptamine analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [7-methyltryptamine analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [CYP2A6 protein results in increased metabolism of coumarin] which results in increased chemical synthesis of 7-hydroxycoumarin; [indopan analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [indopan results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [Tranylcypromine results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [Tryptamines analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; coumarin inhibits the reaction [CYP2A6 protein results in increased glutathionylation of Lamotrigine]; CYP2A6 protein binds to and results in increased metabolism of coumarin; CYP2A6 protein results in increased metabolism of and affects the abundance of coumarin; Methoxsalen inhibits the reaction [CYP2A6 protein results in increased metabolism of coumarin]; nitrosobenzylmethylamine inhibits the reaction [CYP2A6 protein results in increased hydroxylation of coumarin]; perfluorooctane sulfonic acid inhibits the reaction [CYP2A6 protein results in increased hydroxylation of coumarin]; Proadifen inhibits the reaction [CYP2A6 protein results in increased metabolism of coumarin]; Tranylcypromine inhibits the reaction [CYP2A6 protein results in increased metabolism of coumarin]
CYP2A6 exon SNP results in increased metabolism of coumarin; CYP2A6 protein results in increased metabolism of coumarin
CYP2A6 promoter SNP affects the metabolism of coumarin; CYP2A6 protein affects the metabolism of coumarin; CYP2A6 protein mutant form affects the metabolism of coumarin
CYP2A6 exon SNP results in decreased metabolism of coumarin
CTD PMID:8819299, PMID:10616189, PMID:11237731, PMID:11376561, PMID:11393269, PMID:11504148, PMID:11684323, PMID:11779172, PMID:11927840, PMID:12325023, PMID:12401345, PMID:12406643, PMID:12433797, PMID:12464242, PMID:12818727, PMID:14583682, PMID:15155557, PMID:15592323, PMID:15618666, PMID:15626586, PMID:15681899, PMID:15728263, PMID:15980104, PMID:16035375, PMID:16124035, PMID:16126166, PMID:16207711, PMID:17220563, PMID:17565714, PMID:18216723, PMID:18979093, PMID:19082995, PMID:19961160, PMID:21915887, PMID:21964418, PMID:22634058, PMID:24924949, PMID:26599973, PMID:32198085 NCBI chr 7:26,307,192...26,315,088
Ensembl chr 7:26,307,169...26,315,088
JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 affects metabolic processing
decreases hydroxylation
increases hydroxylation
EXP
ISO
CYP2A5 protein affects the metabolism of coumarin
CYP2A13 gene polymorphism results in decreased hydroxylation of coumarin
CYP2A13 protein results in increased hydroxylation of coumarin
CTD PMID:10646973, PMID:17922361 NCBI chr 7:26,835,339...26,843,264
Ensembl chr 7:26,835,305...26,843,548
JBrowse link
G Cyp2c52-ps cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene decreases expression ISO coumarin results in decreased expression of CYP2C mRNA CTD PMID:18480146 NCBI chr19:38,976,662...39,003,627
Ensembl chr19:38,976,647...39,003,289
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 affects response to substance
affects metabolic processing
ISO CYP2C9 protein polymorphism affects the susceptibility to coumarin
CYP2C9 protein polymorphism affects the metabolism of coumarin
CTD PMID:17849045, PMID:23582453 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 affects response to substance
affects metabolic processing
ISO CYP2C9 protein polymorphism affects the susceptibility to coumarin
CYP2C9 protein polymorphism affects the metabolism of coumarin
CTD PMID:17849045, PMID:23582453 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects localization ISO coumarin affects the localization of CYP2E1 protein CTD PMID:28803882 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp51 cytochrome P450, family 51 decreases expression ISO coumarin results in decreased expression of CYP51 mRNA CTD PMID:18480146 NCBI chr 5:4,080,674...4,104,697
Ensembl chr 5:4,081,145...4,104,746
JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 decreases expression ISO coumarin results in decreased expression of CYP7A1 mRNA CTD PMID:18480146 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression ISO coumarin results in increased expression of DDIT4L mRNA CTD PMID:18480146 NCBI chr 3:137,623,672...137,628,332
Ensembl chr 3:137,621,612...137,628,333
JBrowse link
G Ddost dolichyl-di-phosphooligosaccharide-protein glycotransferase increases expression ISO coumarin results in increased expression of DDOST mRNA CTD PMID:18480146 NCBI chr 4:138,304,738...138,312,619
Ensembl chr 4:138,304,730...138,312,628
JBrowse link
G Ddx31 DEAD/H box helicase 31 decreases expression ISO coumarin results in decreased expression of DDX31 mRNA CTD PMID:18480146 NCBI chr 2:28,840,406...28,905,575
Ensembl chr 2:28,840,406...28,905,571
JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 increases expression ISO coumarin results in increased expression of DNAJB11 mRNA CTD PMID:18480146 NCBI chr16:22,857,845...22,879,634
Ensembl chr16:22,857,845...22,879,634
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 affects expression ISO coumarin affects the expression of DNAJB9 mRNA CTD PMID:16963487 NCBI chr12:44,205,897...44,210,068
Ensembl chr12:44,205,559...44,210,326
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression ISO coumarin results in increased expression of DNAJC3 mRNA CTD PMID:18480146 NCBI chr14:118,937,932...118,981,702
Ensembl chr14:118,937,976...118,981,697
JBrowse link
G Dscc1 DNA replication and sister chromatid cohesion 1 increases expression ISO coumarin results in increased expression of DSCC1 mRNA CTD PMID:18480146 NCBI chr15:55,076,101...55,090,491
Ensembl chr15:55,076,099...55,090,491
JBrowse link
G Eci1 enoyl-Coenzyme A delta isomerase 1 affects expression ISO coumarin affects the expression of ECI1 mRNA CTD PMID:16963487 NCBI chr17:24,426,683...24,439,316
Ensembl chr17:24,426,641...24,439,348
JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 increases expression ISO coumarin results in increased expression of EEF1E1 mRNA CTD PMID:18480146 NCBI chr13:38,645,691...38,659,028
Ensembl chr13:38,644,207...38,659,058
JBrowse link
G Ell3 elongation factor RNA polymerase II-like 3 increases expression ISO coumarin results in increased expression of ELL3 mRNA CTD PMID:18480146 NCBI chr 2:121,439,027...121,442,601
Ensembl chr 2:121,439,010...121,444,278
JBrowse link
G Eme2 essential meiotic structure-specific endonuclease subunit 2 increases expression ISO coumarin results in increased expression of EME2 mRNA CTD PMID:18480146 NCBI chr17:24,892,152...24,895,087
Ensembl chr17:24,888,486...24,895,087
JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal increases expression EXP coumarin results in increased expression of EPHX1 mRNA CTD PMID:17311802 NCBI chr 1:180,989,556...181,017,569
Ensembl chr 1:180,976,210...181,020,904
JBrowse link
G F9 coagulation factor IX increases response to substance ISO F9 exon polymorphism results in increased susceptibility to coumarin; F9 protein mutant form results in increased susceptibility to coumarin CTD PMID:11307814 NCBI chr  X:59,999,329...60,030,760
Ensembl chr  X:59,999,464...60,030,759
JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression ISO coumarin results in decreased expression of FADS1 mRNA CTD PMID:18480146 NCBI chr19:10,182,877...10,196,874
Ensembl chr19:10,182,888...10,196,877
JBrowse link
G Fam111a family with sequence similarity 111, member A increases expression ISO coumarin results in increased expression of FAM111A mRNA CTD PMID:18480146 NCBI chr19:12,573,510...12,589,769
Ensembl chr19:12,545,740...12,589,768
JBrowse link
G Fasn fatty acid synthase affects expression ISO coumarin affects the expression of FASN mRNA CTD PMID:16963487 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547
JBrowse link
G Fen1 flap structure specific endonuclease 1 increases expression ISO coumarin results in increased expression of FEN1 mRNA CTD PMID:18480146 NCBI chr19:10,199,132...10,204,393
Ensembl chr19:10,199,132...10,204,169
JBrowse link
G Fgg fibrinogen gamma chain affects expression ISO coumarin affects the expression of FGG mRNA CTD PMID:16963487 NCBI chr 3:83,007,724...83,015,056
Ensembl chr 3:83,007,724...83,015,049
JBrowse link
G Fggy FGGY carbohydrate kinase domain containing decreases expression ISO coumarin results in decreased expression of FGGY mRNA CTD PMID:18480146 NCBI chr 4:95,557,480...95,926,939
Ensembl chr 4:95,557,507...95,926,939
JBrowse link
G Fkbp11 FK506 binding protein 11 increases expression ISO coumarin results in increased expression of FKBP11 mRNA CTD PMID:18480146 NCBI chr15:98,724,368...98,728,198
Ensembl chr15:98,724,366...98,728,198
JBrowse link
G Fmo1 flavin containing monooxygenase 1 decreases expression ISO coumarin results in decreased expression of FMO1 mRNA CTD PMID:18480146 NCBI chr 1:162,829,561...162,866,610
Ensembl chr 1:162,829,561...162,866,610
JBrowse link
G Gas5 growth arrest specific 5 increases expression ISO coumarin results in increased expression of GAS5 mRNA CTD PMID:18480146 NCBI chr 1:161,034,601...161,038,539
Ensembl chr 1:161,034,422...161,038,539
JBrowse link
G Gckr glucokinase regulatory protein decreases expression ISO coumarin results in decreased expression of GCKR mRNA CTD PMID:18480146 NCBI chr 5:31,297,266...31,327,302
Ensembl chr 5:31,297,443...31,327,314
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO coumarin results in increased expression of GCLC mRNA CTD PMID:18480146 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO coumarin results in increased expression of GCLM mRNA CTD PMID:18480146 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Gjb2 gap junction protein, beta 2 increases expression ISO coumarin results in increased expression of GJB2 mRNA CTD PMID:18480146 NCBI chr14:57,098,602...57,104,702
Ensembl chr14:57,098,600...57,104,702
JBrowse link
G Gk glycerol kinase decreases expression ISO coumarin results in decreased expression of GK mRNA CTD PMID:18480146 NCBI chr  X:85,701,937...85,776,819
Ensembl chr  X:85,701,937...85,776,819
JBrowse link
G Glb1 galactosidase, beta 1 increases expression ISO coumarin results in increased expression of GLB1 mRNA CTD PMID:18480146 NCBI chr 9:114,401,078...114,474,379
Ensembl chr 9:114,401,076...114,474,898
JBrowse link
G Gldc glycine decarboxylase decreases expression ISO coumarin results in decreased expression of GLDC mRNA CTD PMID:18480146 NCBI chr19:30,098,441...30,175,441
Ensembl chr19:30,098,447...30,175,429
JBrowse link
G Gm715 predicted gene 715 increases expression ISO coumarin results in increased expression of RGD1560171 mRNA CTD PMID:18480146 NCBI chr  X:60,548,008...60,549,217
Ensembl chr  X:60,548,019...60,548,849
JBrowse link
G Gpr108 G protein-coupled receptor 108 decreases expression ISO coumarin results in decreased expression of GPR108 mRNA CTD PMID:18480146 NCBI chr17:57,234,914...57,248,743
Ensembl chr17:57,234,635...57,248,446
JBrowse link
G Gpx1 glutathione peroxidase 1 affects expression ISO coumarin affects the expression of GPX1 mRNA CTD PMID:16963487 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343
JBrowse link
G Gsr glutathione reductase increases expression ISO coumarin results in increased expression of GSR mRNA CTD PMID:18480146 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Gsta1 glutathione S-transferase, alpha 1 (Ya) increases expression ISO
EXP
coumarin results in increased expression of GSTA5 protein
coumarin results in increased expression of GSTA1 protein
CTD PMID:9794803, PMID:11309284 NCBI chr 9:78,230,669...78,242,683
Ensembl chr 9:78,230,656...78,242,684
JBrowse link
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) increases expression EXP coumarin results in increased expression of GSTA2 protein CTD PMID:11309284 NCBI chr 9:78,331,018...78,347,192
Ensembl chr 9:78,331,018...78,355,788
JBrowse link
G Gsta3 glutathione S-transferase, alpha 3 increases expression EXP
ISO
coumarin results in increased expression of GSTA3 protein CTD PMID:9794803, PMID:11309284 NCBI chr 1:21,240,565...21,265,575
Ensembl chr 1:21,240,589...21,265,661
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP coumarin results in increased expression of GSTA4 protein CTD PMID:11309284 NCBI chr 9:78,289,928...78,305,525
Ensembl chr 9:78,289,923...78,305,525
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 increases expression EXP coumarin results in increased expression of GSTM5 protein CTD PMID:11309284 NCBI chr 3:108,012,250...108,017,973
Ensembl chr 3:108,012,255...108,017,973
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO coumarin results in increased expression of GSTM3 protein CTD PMID:9794803 NCBI chr 3:107,895,854...107,898,685
Ensembl chr 3:107,895,821...107,898,686
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 increases expression EXP
ISO
coumarin results in increased expression of GSTP1 protein CTD PMID:9794803, PMID:11309284 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Gstp2 glutathione S-transferase, pi 2 increases expression EXP coumarin results in increased expression of GSTP2 protein CTD PMID:11309284 NCBI chr19:4,040,288...4,042,221
Ensembl chr19:4,040,285...4,046,023
JBrowse link
G Gstt1 glutathione S-transferase, theta 1 increases expression ISO coumarin results in increased expression of GSTT1 mRNA; coumarin results in increased expression of GSTT1 protein CTD PMID:9794803, PMID:9855024, PMID:10413528 NCBI chr10:75,783,813...75,798,584
Ensembl chr10:75,783,813...75,798,584
JBrowse link
G H2-Aa histocompatibility 2, class II antigen A, alpha increases expression ISO coumarin results in increased expression of RT1-BA mRNA CTD PMID:18480146 NCBI chr17:34,282,744...34,287,823
Ensembl chr17:34,282,744...34,287,823
JBrowse link
G H2-DMa histocompatibility 2, class II, locus DMa increases expression ISO coumarin results in increased expression of HLA-DMA mRNA CTD PMID:18480146 NCBI chr17:34,119,693...34,139,101
Ensembl chr17:34,119,541...34,139,101
JBrowse link
G Hal histidine ammonia lyase decreases expression ISO coumarin results in decreased expression of HAL mRNA CTD PMID:18480146 NCBI chr10:93,488,768...93,516,761
Ensembl chr10:93,488,768...93,519,304
JBrowse link
G Hao2 hydroxyacid oxidase 2 decreases expression ISO coumarin results in decreased expression of HAO2 mRNA CTD PMID:18480146 NCBI chr 3:98,874,519...98,895,376
Ensembl chr 3:98,874,521...98,893,239
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 multiple interactions ISO coumarin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased glycosylation of HBA1 protein] CTD PMID:19647726 NCBI chr11:32,296,492...32,297,310
Ensembl chr11:32,296,489...32,297,298
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit increases expression ISO coumarin analog results in increased expression of HIF1A mRNA CTD PMID:32578917 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase increases expression ISO coumarin results in increased expression of HMGCR mRNA CTD PMID:18480146 NCBI chr13:96,648,962...96,670,936
Ensembl chr13:96,648,967...96,670,936
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 multiple interactions ISO coumarin analog inhibits the reaction [[HSD17B1 protein co-treated with NADP] results in increased reduction of Estrone] CTD PMID:21232530 NCBI chr11:101,077,968...101,081,188
Ensembl chr11:101,078,411...101,080,527
JBrowse link
G Hsp90b1 heat shock protein 90, beta (Grp94), member 1 increases expression ISO coumarin results in increased expression of HSP90B1 mRNA CTD PMID:18480146 NCBI chr10:86,690,841...86,705,444
Ensembl chr10:86,690,209...86,705,509
JBrowse link
G Hspa1b heat shock protein 1B increases expression ISO coumarin results in increased expression of HSPA1B mRNA CTD PMID:18480146 NCBI chr17:34,956,429...34,959,238
Ensembl chr17:34,956,436...34,959,238
JBrowse link
G Hyou1 hypoxia up-regulated 1 increases expression ISO coumarin results in increased expression of HYOU1 mRNA CTD PMID:18480146 NCBI chr 9:44,379,490...44,392,369
Ensembl chr 9:44,379,490...44,392,369
JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit decreases expression ISO coumarin results in decreased expression of IGFALS mRNA CTD PMID:18480146 NCBI chr17:24,877,844...24,882,011
Ensembl chr17:24,865,997...24,882,010
JBrowse link
G Il1b interleukin 1 beta increases expression
decreases expression
ISO coumarin results in increased expression of IL1B mRNA
coumarin analog results in decreased expression of IL1B protein
CTD PMID:15135310, PMID:32578917 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 increases expression
decreases expression
ISO coumarin results in increased expression of IL6 mRNA
coumarin analog results in decreased expression of IL6 mRNA; coumarin analog results in decreased expression of IL6 protein
CTD PMID:15135310, PMID:32578917 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Isyna1 myo-inositol 1-phosphate synthase A1 increases expression ISO coumarin results in increased expression of ISYNA1 mRNA CTD PMID:18480146 NCBI chr 8:70,594,481...70,597,290
Ensembl chr 8:70,594,373...70,597,290
JBrowse link
G Josd2 Josephin domain containing 2 increases expression ISO coumarin results in increased expression of JOSD2 mRNA CTD PMID:18480146 NCBI chr 7:44,467,980...44,471,658
Ensembl chr 7:44,467,980...44,471,662
JBrowse link
G Kcnk2 potassium channel, subfamily K, member 2 increases expression ISO coumarin results in increased expression of KCNK2 mRNA CTD PMID:18480146 NCBI chr 1:189,207,930...189,402,782
Ensembl chr 1:189,207,930...189,402,273
JBrowse link
G Kdr kinase insert domain protein receptor increases expression ISO coumarin analog results in increased expression of KDR mRNA CTD PMID:32578917 NCBI chr 5:75,932,827...75,979,072
Ensembl chr 5:75,932,827...75,978,458
JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO coumarin results in decreased expression of KIF20A mRNA CTD PMID:18480146 NCBI chr18:34,624,624...34,633,277
Ensembl chr18:34,624,613...34,633,277
JBrowse link
G Klf2 Kruppel-like factor 2 (lung) decreases expression ISO coumarin results in decreased expression of KLF2 mRNA CTD PMID:18480146 NCBI chr 8:72,319,062...72,321,654
Ensembl chr 8:72,319,033...72,321,656
JBrowse link
G Krt19 keratin 19 decreases expression ISO coumarin results in decreased expression of KRT19 mRNA CTD PMID:18480146 NCBI chr11:100,140,810...100,145,926
Ensembl chr11:100,140,810...100,148,665
JBrowse link
G Kynu kynureninase decreases expression ISO coumarin results in decreased expression of KYNU mRNA CTD PMID:18480146 NCBI chr 2:43,555,258...43,683,048
Ensembl chr 2:43,555,329...43,682,715
JBrowse link
G Lad1 ladinin increases expression ISO coumarin results in increased expression of LAD1 mRNA CTD PMID:18480146 NCBI chr 1:135,818,598...135,833,341
Ensembl chr 1:135,818,598...135,833,342
JBrowse link
G Lmf2 lipase maturation factor 2 increases expression ISO coumarin results in increased expression of LMF2 mRNA CTD PMID:18480146 NCBI chr15:89,351,004...89,355,694
Ensembl chr15:89,351,004...89,355,659
JBrowse link
G Lrp3 low density lipoprotein receptor-related protein 3 affects expression ISO coumarin affects the expression of LRP3 mRNA CTD PMID:16963487 NCBI chr 7:35,200,878...35,217,392
Ensembl chr 7:35,200,027...35,215,498
JBrowse link
G Mat1a methionine adenosyltransferase I, alpha affects expression ISO coumarin affects the expression of MAT1A mRNA CTD PMID:16963487 NCBI chr14:41,105,012...41,124,428
Ensembl chr14:41,105,035...41,124,412
JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 decreases expression ISO coumarin results in decreased expression of MBL2 mRNA CTD PMID:18480146 NCBI chr19:30,232,906...30,239,687
Ensembl chr19:30,232,942...30,239,687
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 increases expression ISO coumarin results in increased expression of MCM2 mRNA CTD PMID:18480146 NCBI chr 6:88,883,474...88,898,780
Ensembl chr 6:88,883,474...88,898,780
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO coumarin results in increased expression of MCM3 mRNA CTD PMID:18480146 NCBI chr 1:20,802,966...20,820,312
Ensembl chr 1:20,802,968...20,820,312
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 increases expression ISO coumarin results in increased expression of MCM4 mRNA CTD PMID:18480146 NCBI chr16:15,623,897...15,637,400
Ensembl chr16:15,623,897...15,637,400
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 increases expression ISO coumarin results in increased expression of MCM5 mRNA CTD PMID:18480146 NCBI chr 8:75,109,468...75,128,439
Ensembl chr 8:75,109,569...75,128,439
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 decreases expression ISO coumarin analog results in decreased expression of MDM2 mRNA CTD PMID:32578917 NCBI chr10:117,688,875...117,710,758
Ensembl chr10:117,688,875...117,710,758
JBrowse link
G Mgp matrix Gla protein decreases expression ISO
EXP
coumarin results in decreased expression of MGP mRNA CTD PMID:19350115 NCBI chr 6:136,872,435...136,875,823
Ensembl chr 6:136,872,435...136,875,823
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 increases expression ISO coumarin results in increased expression of MGST2 mRNA CTD PMID:18480146 NCBI chr 3:51,636,912...51,682,675
Ensembl chr 3:51,660,360...51,682,677
JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 decreases expression ISO coumarin results in decreased expression of MGST3 mRNA CTD PMID:18480146 NCBI chr 1:167,371,966...167,393,841
Ensembl chr 1:167,371,966...167,393,841
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO coumarin analog results in decreased expression of MMP2 mRNA CTD PMID:32578917 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO coumarin analog results in decreased expression of and results in decreased activity of MMP9 protein
coumarin analog results in decreased expression of MMP9 mRNA
CTD PMID:32578917 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Mms22l MMS22-like, DNA repair protein increases expression ISO coumarin results in increased expression of MMS22L mRNA CTD PMID:18480146 NCBI chr 4:24,496,451...24,602,950
Ensembl chr 4:24,496,451...24,602,950
JBrowse link
G Msmo1 methylsterol monoxygenase 1 affects expression ISO coumarin affects the expression of MSMO1 mRNA CTD PMID:16963487 NCBI chr 8:64,718,123...64,733,578
Ensembl chr 8:64,718,139...64,733,792
JBrowse link
G Mt1 metallothionein 1 increases expression ISO coumarin results in increased expression of MT1A mRNA CTD PMID:18480146 NCBI chr 8:94,178,883...94,180,327
Ensembl chr 8:94,179,082...94,180,327
JBrowse link
G Mt2 metallothionein 2 increases expression ISO coumarin results in increased expression of MT2A mRNA CTD PMID:18480146 NCBI chr 8:94,172,618...94,173,567
Ensembl chr 8:94,172,664...94,173,568
JBrowse link
G Nectin2 nectin cell adhesion molecule 2 decreases expression ISO coumarin results in decreased expression of NECTIN2 mRNA CTD PMID:18480146 NCBI chr 7:19,716,644...19,749,573
Ensembl chr 7:19,716,644...19,750,483
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects activity
increases activity
EXP coumarin affects the activity of NFE2L2 protein
coumarin results in increased activity of NFE2L2 protein
CTD PMID:11309284, PMID:30114225, PMID:30203046 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nol3 nucleolar protein 3 (apoptosis repressor with CARD domain) increases expression ISO coumarin results in increased expression of NOL3 mRNA CTD PMID:18480146 NCBI chr 8:105,276,145...105,281,939
Ensembl chr 8:105,276,140...105,281,939
JBrowse link
G Nol8 nucleolar protein 8 increases expression ISO coumarin results in increased expression of NOL8 mRNA CTD PMID:18480146 NCBI chr13:49,653,078...49,679,016
Ensembl chr13:49,653,078...49,679,016
JBrowse link
G Nop56 NOP56 ribonucleoprotein increases expression ISO coumarin results in increased expression of NOP56 mRNA CTD PMID:18480146 NCBI chr 2:130,274,367...130,279,313
Ensembl chr 2:130,274,430...130,279,313
JBrowse link
G Nos2 nitric oxide synthase 2, inducible increases expression ISO coumarin results in increased expression of NOS2 mRNA
coumarin analog results in increased expression of NOS2 mRNA; coumarin analog results in increased expression of NOS2 protein
CTD PMID:15135310, PMID:32578917 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression EXP
ISO
coumarin results in increased expression of NQO1 mRNA; coumarin results in increased expression of NQO1 protein CTD PMID:11309284, PMID:17311802, PMID:18480146 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO coumarin results in increased expression of NR0B2 mRNA CTD PMID:18480146 NCBI chr 4:133,553,376...133,556,686
Ensembl chr 4:133,553,376...133,556,536
JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression ISO coumarin results in increased expression of NR1D2 mRNA CTD PMID:18480146 NCBI chr14:18,204,056...18,239,106
Ensembl chr14:18,204,054...18,239,127
JBrowse link
G Nrep neuronal regeneration related protein decreases expression ISO coumarin results in decreased expression of NREP mRNA CTD PMID:18480146 NCBI chr18:33,437,019...33,464,365
Ensembl chr18:33,437,019...33,464,029
JBrowse link
G Nrtn neurturin increases expression ISO coumarin results in increased expression of NRTN mRNA CTD PMID:18480146 NCBI chr17:56,751,323...56,757,548
Ensembl chr17:56,751,325...56,757,530
JBrowse link
G Ntng1 netrin G1 decreases expression ISO coumarin results in decreased expression of NTNG1 mRNA CTD PMID:18480146 NCBI chr 3:109,780,050...110,149,972
Ensembl chr 3:109,780,040...110,144,011
JBrowse link
G Nupr1 nuclear protein transcription regulator 1 increases expression ISO coumarin results in increased expression of NUPR1 mRNA CTD PMID:18480146 NCBI chr 7:126,623,246...126,625,470
Ensembl chr 7:126,623,249...126,630,861
JBrowse link
G Oaf out at first homolog decreases expression ISO coumarin results in decreased expression of OAF mRNA CTD PMID:18480146 NCBI chr 9:43,221,278...43,239,816
Ensembl chr 9:43,221,235...43,239,911
JBrowse link
G Oat ornithine aminotransferase decreases expression ISO coumarin results in decreased expression of OAT mRNA CTD PMID:18480146 NCBI chr 7:132,557,475...132,576,398
Ensembl chr 7:132,557,478...132,576,398
JBrowse link
G Ogn osteoglycin decreases expression ISO coumarin results in decreased expression of OGN mRNA CTD PMID:18480146 NCBI chr13:49,608,015...49,624,501
Ensembl chr13:49,608,046...49,624,501
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 decreases activity
decreases expression
increases cleavage
multiple interactions
ISO coumarin results in decreased activity of PARP1 protein
coumarin analog results in decreased expression of PARP1 mRNA
coumarin analog results in increased cleavage of PARP1 protein
[coumarin results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NAD]; [coumarin results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NADP]
CTD PMID:17669606, PMID:31199928, PMID:32578917 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) increases expression ISO coumarin results in increased expression of PCK2 mRNA CTD PMID:18480146 NCBI chr14:55,540,263...55,550,020
Ensembl chr14:55,540,266...55,551,242
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO coumarin analog results in increased expression of PCNA mRNA CTD PMID:32578917 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific decreases expression ISO coumarin results in decreased expression of PDE4B mRNA CTD PMID:18480146 NCBI chr 4:102,087,332...102,607,275
Ensembl chr 4:102,087,543...102,607,259
JBrowse link
G Pdia3 protein disulfide isomerase associated 3 increases expression ISO coumarin results in increased expression of PDIA3 mRNA CTD PMID:18480146 NCBI chr 2:121,413,902...121,438,687
Ensembl chr 2:121,413,775...121,438,687
JBrowse link
G Pdia4 protein disulfide isomerase associated 4 increases expression ISO coumarin results in increased expression of PDIA4 mRNA CTD PMID:18480146 NCBI chr 6:47,796,141...47,813,512
Ensembl chr 6:47,796,141...47,813,430
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase, isoenzyme 2 decreases expression ISO coumarin results in decreased expression of PDK2 mRNA CTD PMID:18480146 NCBI chr11:95,026,258...95,041,371
Ensembl chr11:95,026,258...95,041,354
JBrowse link
G Pla2g12a phospholipase A2, group XIIA increases expression ISO coumarin results in increased expression of PLA2G12A mRNA CTD PMID:18480146 NCBI chr 3:129,878,606...129,895,825
Ensembl chr 3:129,878,606...129,895,825
JBrowse link
G Pold1 polymerase (DNA directed), delta 1, catalytic subunit increases expression ISO coumarin results in increased expression of POLD1 mRNA CTD PMID:18480146 NCBI chr 7:44,532,744...44,548,815
Ensembl chr 7:44,532,746...44,548,849
JBrowse link
G Pold2 polymerase (DNA directed), delta 2, regulatory subunit increases expression ISO coumarin results in increased expression of POLD2 mRNA CTD PMID:18480146 NCBI chr11:5,872,180...5,878,256
Ensembl chr11:5,872,180...5,878,292
JBrowse link
G Polr1e polymerase (RNA) I polypeptide E increases expression ISO coumarin results in increased expression of POLR1E mRNA CTD PMID:18480146 NCBI chr 4:45,018,609...45,034,279
Ensembl chr 4:45,018,583...45,036,565
JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO coumarin results in increased expression of PTGR1 mRNA CTD PMID:18480146 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119
JBrowse link
G R3hdm1 R3H domain containing 1 increases expression ISO coumarin results in increased expression of R3HDM1 mRNA CTD PMID:18480146 NCBI chr 1:128,103,282...128,237,738
Ensembl chr 1:128,103,301...128,237,736
JBrowse link
G R3hdm2 R3H domain containing 2 decreases expression ISO coumarin results in decreased expression of R3HDM2 mRNA CTD PMID:18480146 NCBI chr10:127,380,332...127,499,384
Ensembl chr10:127,380,327...127,499,384
JBrowse link
G Rab3d RAB3D, member RAS oncogene family increases expression ISO coumarin results in increased expression of RAB3D mRNA CTD PMID:18480146 NCBI chr 9:21,907,491...21,918,199
Ensembl chr 9:21,907,491...21,918,192
JBrowse link
G Rbm3 RNA binding motif (RNP1, RRM) protein 3 increases expression ISO coumarin results in increased expression of RBM3 mRNA CTD PMID:18480146 NCBI chr  X:8,138,975...8,145,880
Ensembl chr  X:8,138,975...8,145,880
JBrowse link
G Rbp1 retinol binding protein 1, cellular decreases expression ISO coumarin results in decreased expression of RBP1 mRNA CTD PMID:18480146 NCBI chr 9:98,422,961...98,446,551
Ensembl chr 9:98,422,961...98,446,575
JBrowse link
G Rgn regucalcin decreases expression ISO coumarin results in decreased expression of RGN mRNA CTD PMID:18480146 NCBI chr  X:20,549,766...20,562,089
Ensembl chr  X:20,549,787...20,562,089
JBrowse link
G Rgs8 regulator of G-protein signaling 8 decreases expression ISO coumarin results in decreased expression of RGS8 mRNA CTD PMID:18480146 NCBI chr 1:153,652,959...153,697,669
Ensembl chr 1:153,653,025...153,700,323
JBrowse link
G Rprm reprimo, TP53 dependent G2 arrest mediator candidate decreases expression ISO coumarin results in decreased expression of RPRM mRNA CTD PMID:18480146 NCBI chr 2:54,084,093...54,085,552
Ensembl chr 2:54,084,093...54,085,552
JBrowse link
G Saraf store-operated calcium entry-associated regulatory factor increases expression ISO coumarin results in increased expression of SARAF mRNA CTD PMID:18480146 NCBI chr 8:34,154,579...34,170,847
Ensembl chr 8:34,154,575...34,170,821
Ensembl chr 8:34,154,575...34,170,821
JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 decreases expression ISO coumarin results in decreased expression of SCD1 mRNA CTD PMID:18480146 NCBI chr19:44,394,450...44,407,709
Ensembl chr19:44,394,455...44,407,879
JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 increases expression ISO coumarin results in increased expression of SDF2L1 mRNA CTD PMID:18480146 NCBI chr16:17,130,138...17,132,383
Ensembl chr16:17,130,138...17,132,383
JBrowse link
G Sel1l sel-1 suppressor of lin-12-like (C. elegans) increases expression ISO coumarin results in increased expression of SEL1L mRNA CTD PMID:18480146 NCBI chr12:91,806,043...91,849,157
Ensembl chr12:91,806,043...91,849,157
JBrowse link
G Sema6d sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D increases expression ISO coumarin results in increased expression of SEMA6D mRNA CTD PMID:18480146 NCBI chr 2:124,089,943...124,667,789
Ensembl chr 2:124,089,969...124,667,770
JBrowse link
G Slc17a1 solute carrier family 17 (sodium phosphate), member 1 increases expression ISO coumarin results in increased expression of SLC17A1 mRNA CTD PMID:18480146 NCBI chr13:23,867,624...23,895,730
Ensembl chr13:23,867,750...23,895,730
JBrowse link
G Slc17a3 solute carrier family 17 (sodium phosphate), member 3 increases expression ISO coumarin results in increased expression of SLC17A3 mRNA CTD PMID:18480146 NCBI chr13:23,836,922...23,860,718
Ensembl chr13:23,839,434...23,860,716
JBrowse link
G Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 increases expression ISO coumarin results in increased expression of SLC1A2 mRNA CTD PMID:18480146 NCBI chr 2:102,658,239...102,790,784
Ensembl chr 2:102,658,659...102,790,784
JBrowse link
G Slc27a2 solute carrier family 27 (fatty acid transporter), member 2 affects expression ISO coumarin affects the expression of SLC27A2 mRNA CTD PMID:16963487 NCBI chr 2:126,553,024...126,588,243
Ensembl chr 2:126,552,407...126,588,243
JBrowse link
G Slc28a2 solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 decreases expression ISO coumarin results in decreased expression of SLC28A2 mRNA CTD PMID:18480146 NCBI chr 2:122,426,357...122,461,152
Ensembl chr 2:122,426,477...122,461,137
JBrowse link
G Slc35e3 solute carrier family 35, member E3 increases expression ISO coumarin results in increased expression of SLC35E3 mRNA CTD PMID:18480146 NCBI chr10:117,733,678...117,746,358
Ensembl chr10:117,733,679...117,746,365
JBrowse link
G Slc6a13 solute carrier family 6 (neurotransmitter transporter, GABA), member 13 decreases expression ISO coumarin results in decreased expression of SLC6A13 mRNA CTD PMID:18480146 NCBI chr 6:121,300,288...121,337,721
Ensembl chr 6:121,300,227...121,337,733
JBrowse link
G Slc6a9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 increases expression ISO coumarin results in increased expression of SLC6A9 mRNA CTD PMID:18480146 NCBI chr 4:117,835,258...117,869,305
Ensembl chr 4:117,834,506...117,875,198
JBrowse link
G Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B increases expression ISO coumarin results in increased expression of SMPDL3B mRNA CTD PMID:18480146 NCBI chr 4:132,732,966...132,757,171
Ensembl chr 4:132,732,966...132,757,252
JBrowse link
G Snai2 snail family zinc finger 2 decreases expression ISO coumarin analog results in decreased expression of SNAI2 mRNA CTD PMID:32578917 NCBI chr16:14,705,852...14,709,395
Ensembl chr16:14,705,852...14,709,385
JBrowse link
G Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) increases expression ISO coumarin results in increased expression of SRXN1 mRNA CTD PMID:18480146 NCBI chr 2:152,105,524...152,111,376
Ensembl chr 2:152,105,516...152,111,376
JBrowse link
G Stat5b signal transducer and activator of transcription 5B increases activity EXP coumarin results in increased activity of STAT5B protein CTD PMID:30114225 NCBI chr11:100,780,731...100,859,004
Ensembl chr11:100,780,731...100,850,724
JBrowse link
G Sult1b1 sulfotransferase family 1B, member 1 affects expression ISO coumarin affects the expression of SULT1B1 mRNA CTD PMID:16963487 NCBI chr 5:87,513,327...87,538,195
Ensembl chr 5:87,513,339...87,538,195
JBrowse link
G Sult1c1 sulfotransferase family, cytosolic, 1C, member 1 decreases expression ISO coumarin results in decreased expression of SULT1C1 mRNA CTD PMID:18480146 NCBI chr17:53,961,615...53,990,631
Ensembl chr17:53,961,615...53,990,674
JBrowse link
G Sult1e1 sulfotransferase family 1E, member 1 decreases expression ISO coumarin results in decreased expression of SULT1E1 mRNA CTD PMID:18480146 NCBI chr 5:87,575,968...87,591,611
Ensembl chr 5:87,575,969...87,591,594
JBrowse link
G Sycp3 synaptonemal complex protein 3 decreases expression ISO coumarin results in decreased expression of SYCP3 mRNA CTD PMID:18480146 NCBI chr10:88,459,587...88,473,236
Ensembl chr10:88,459,569...88,473,236
JBrowse link
G Syne4 spectrin repeat containing, nuclear envelope family member 4 increases expression ISO coumarin results in increased expression of SYNE4 mRNA CTD PMID:18480146 NCBI chr 7:30,314,816...30,319,045
Ensembl chr 7:30,314,807...30,319,046
JBrowse link
G Tfrc transferrin receptor increases expression ISO coumarin results in increased expression of TFRC mRNA CTD PMID:18480146 NCBI chr16:32,608,896...32,632,794
Ensembl chr16:32,608,920...32,632,794
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO coumarin analog results in increased expression of TGFB1 mRNA CTD PMID:32578917 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Thra thyroid hormone receptor alpha increases expression ISO coumarin results in increased expression of THRA mRNA CTD PMID:18480146 NCBI chr11:98,740,776...98,769,006
Ensembl chr11:98,740,638...98,769,006
JBrowse link
G Thrsp thyroid hormone responsive affects expression
decreases expression
ISO coumarin affects the expression of THRSP mRNA
coumarin results in decreased expression of THRSP mRNA
CTD PMID:16963487, PMID:18480146 NCBI chr 7:97,412,933...97,417,550
Ensembl chr 7:97,412,938...97,417,730
JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 increases expression ISO coumarin analog results in increased expression of TIMP2 mRNA CTD PMID:32578917 NCBI chr11:118,301,061...118,355,411
Ensembl chr11:118,301,069...118,355,740
JBrowse link
G Timp4 tissue inhibitor of metalloproteinase 4 increases expression ISO coumarin analog results in increased expression of TIMP4 mRNA CTD PMID:32578917 NCBI chr 6:115,244,444...115,252,205
Ensembl chr 6:115,241,892...115,252,205
JBrowse link
G Tmed3 transmembrane p24 trafficking protein 3 increases expression ISO coumarin results in increased expression of TMED3 mRNA CTD PMID:18480146 NCBI chr 9:89,699,203...89,705,043
Ensembl chr 9:89,699,206...89,705,068
JBrowse link
G Tnf tumor necrosis factor increases expression ISO coumarin results in increased expression of TNF mRNA
coumarin analog results in increased expression of TNF protein
CTD PMID:15135310, PMID:32578917 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 decreases expression ISO coumarin results in decreased expression of TNFRSF9 mRNA CTD PMID:18480146 NCBI chr 4:150,920,155...150,946,104
Ensembl chr 4:150,914,562...150,946,102
JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO coumarin analog results in increased expression of TRADD mRNA CTD PMID:32578917 NCBI chr 8:105,258,575...105,264,594
Ensembl chr 8:105,258,286...105,264,609
JBrowse link
G Trp53 transformation related protein 53 increases expression ISO coumarin analog results in increased expression of TP53 mRNA; coumarin analog results in increased expression of TP53 protein CTD PMID:32578917 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Trpc2 transient receptor potential cation channel, subfamily C, member 2 increases expression ISO coumarin results in increased expression of TRPC2 mRNA CTD PMID:18480146 NCBI chr 7:102,083,116...102,096,864
Ensembl chr 7:102,083,116...102,096,396
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression ISO coumarin results in decreased expression of TSC22D1 mRNA CTD PMID:18480146 NCBI chr14:76,414,961...76,507,765
Ensembl chr14:76,414,961...76,507,765
JBrowse link
G Tst thiosulfate sulfurtransferase, mitochondrial affects expression ISO coumarin affects the expression of TST mRNA CTD PMID:16963487 NCBI chr15:78,399,556...78,405,865
Ensembl chr15:78,399,556...78,405,907
JBrowse link
G Ttc39a tetratricopeptide repeat domain 39A increases expression ISO coumarin results in increased expression of TTC39A mRNA CTD PMID:18480146 NCBI chr 4:109,394,147...109,444,749
Ensembl chr 4:109,406,623...109,444,745
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO coumarin results in increased expression of TXNRD1 mRNA CTD PMID:18480146 NCBI chr10:82,833,951...82,897,724
Ensembl chr10:82,833,951...82,897,712
JBrowse link
G Ugdh UDP-glucose dehydrogenase increases expression ISO coumarin results in increased expression of UGDH mRNA CTD PMID:18480146 NCBI chr 5:65,413,207...65,435,842
Ensembl chr 5:65,413,221...65,435,949
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO coumarin analog results in increased expression of VEGFA mRNA CTD PMID:32578917 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
G Vim vimentin decreases expression ISO coumarin analog results in decreased expression of VIM protein CTD PMID:32578917 NCBI chr 2:13,574,311...13,582,826
Ensembl chr 2:13,573,927...13,582,826
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases response to substance
increases response to substance
ISO VKORC1 gene mutant form results in decreased susceptibility to coumarin
VKORC1 gene mutant form results in increased susceptibility to coumarin; VKORC1 promoter SNP results in increased susceptibility to coumarin
CTD PMID:17849045, PMID:18278162 NCBI chr 7:127,893,063...127,895,658
Ensembl chr 7:127,886,227...127,895,454
Ensembl chr 7:127,886,227...127,895,454
JBrowse link
G Wee1 WEE 1 homolog 1 (S. pombe) increases expression ISO coumarin results in increased expression of WEE1 mRNA CTD PMID:18480146 NCBI chr 7:110,122,059...110,143,299
Ensembl chr 7:110,122,046...110,143,286
JBrowse link
G Yrdc yrdC domain containing (E.coli) increases expression ISO coumarin results in increased expression of YRDC mRNA CTD PMID:18480146 NCBI chr 4:124,850,759...124,855,242
Ensembl chr 4:124,850,679...124,855,242
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 decreases expression ISO coumarin analog results in decreased expression of ZEB1 mRNA CTD PMID:32578917 NCBI chr18:5,591,327...5,775,468
Ensembl chr18:5,591,860...5,775,467
JBrowse link
G Zfp444 zinc finger protein 444 increases expression ISO coumarin results in increased expression of ZFP444 mRNA CTD PMID:18480146 NCBI chr 7:6,172,468...6,193,104
Ensembl chr 7:6,172,226...6,193,811
JBrowse link
G Zfp593 zinc finger protein 593 increases expression ISO coumarin results in increased expression of ZNF593 mRNA CTD PMID:18480146 NCBI chr 4:134,243,306...134,245,591
Ensembl chr 4:134,243,289...134,245,592
JBrowse link
G Zwint ZW10 interactor increases expression ISO coumarin results in increased expression of ZWINT mRNA CTD PMID:18480146 NCBI chr10:72,654,846...72,674,964
Ensembl chr10:72,654,845...72,674,964
JBrowse link
coumarin 460 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap9 A kinase (PRKA) anchor protein (yotiao) 9 increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of AKAP9 mRNA CTD PMID:19502547 NCBI chr 5:3,927,736...4,080,204
Ensembl chr 5:3,928,054...4,081,310
JBrowse link
G Ankrd37 ankyrin repeat domain 37 increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of ANKRD37 mRNA CTD PMID:19502547 NCBI chr 8:45,996,908...46,000,414
Ensembl chr 8:45,996,902...46,005,707
JBrowse link
G Ar androgen receptor multiple interactions
affects localization
ISO 4-methyl-7-diethylaminocoumarin binds to and results in increased activity of AR protein
4-methyl-7-diethylaminocoumarin affects the localization of AR protein
CTD PMID:28478275 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit increases activity ISO 4-methyl-7-diethylaminocoumarin results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Pfkm phosphofructokinase, muscle increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of PFKM mRNA CTD PMID:19502547 NCBI chr15:98,092,589...98,132,447
Ensembl chr15:98,092,589...98,132,451
JBrowse link
G Psph phosphoserine phosphatase increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of PSPH mRNA CTD PMID:19502547 NCBI chr 5:129,765,558...129,787,443
Ensembl chr 5:129,765,558...129,787,449
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of VEGFA protein CTD PMID:19502547 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
crocin-1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions EXP crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]] CTD PMID:30580027 NCBI chr 9:22,126,727...22,135,746
Ensembl chr 9:22,126,727...22,135,711
JBrowse link
G Akt2 thymoma viral proto-oncogene 2 multiple interactions EXP crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA] CTD PMID:30580027 NCBI chr 7:27,591,552...27,640,826
Ensembl chr 7:27,591,552...27,640,826
JBrowse link
G Bambi BMP and activin membrane-bound inhibitor multiple interactions ISO crocin inhibits the reaction [Cisplatin results in decreased expression of BAMBI mRNA] CTD PMID:32259551 NCBI chr18:3,507,011...3,516,404
Ensembl chr18:3,507,923...3,516,404