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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dye
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Accession:CHEBI:37958 term browser browse the term
Synonyms:related_synonym: Farbstoff;   Farbstoffe;   colorante;   colorantes;   dyes;   teinture;   teintures


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1,4-phenylenediamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC3 ATP binding cassette subfamily C member 3 increases expression EXP 4-phenylenediamine results in increased expression of ABCC3 mRNA CTD PMID:16314067 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253
JBrowse link
G AKR1C2 aldo-keto reductase family 1 member C2 increases activity
increases expression
EXP 4-phenylenediamine results in increased activity of AKR1C2 promoter
4-phenylenediamine results in increased expression of AKR1C2 mRNA
CTD PMID:20491607, PMID:21195160, PMID:25724174 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,400...5,018,031
JBrowse link
G ANXA1 annexin A1 increases expression EXP 4-phenylenediamine results in increased expression of ANXA1 mRNA CTD PMID:16314067 NCBI chr 9:73,151,865...73,170,393
Ensembl chr 9:73,151,865...73,170,393
JBrowse link
G AQP3 aquaporin 3 (Gill blood group) decreases expression EXP 4-phenylenediamine results in decreased expression of AQP3 mRNA CTD PMID:15140218 NCBI chr 9:33,441,154...33,447,596
Ensembl chr 9:33,441,156...33,447,596
JBrowse link
G ATF3 activating transcription factor 3 increases expression EXP 4-phenylenediamine results in increased expression of ATF3 mRNA CTD PMID:16314067, PMID:23999411, PMID:27965148 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777
JBrowse link
G BACH1 BTB domain and CNC homolog 1 multiple interactions EXP BACH1 mRNA promotes the reaction [4-phenylenediamine results in increased expression of HMOX1 mRNA] CTD PMID:26244607 NCBI chr21:29,298,922...29,361,894
Ensembl chr21:29,194,071...29,630,751
JBrowse link
G CARD18 caspase recruitment domain family member 18 increases expression EXP 4-phenylenediamine results in increased expression of CARD18 mRNA CTD PMID:27585668 NCBI chr11:105,137,714...105,139,769
Ensembl chr11:105,137,714...105,531,697
JBrowse link
G CASP1 caspase 1 multiple interactions
increases activity
EXP 4-phenylenediamine promotes the reaction [[NLRP12 protein binds to NLRP3 protein binds to CASP1 protein] which binds to PYCARD protein]
4-phenylenediamine results in increased activity of CASP1 protein
CTD PMID:31276767 NCBI chr11:105,025,443...105,035,591
Ensembl chr11:105,025,443...105,035,250
JBrowse link
G CASP3 caspase 3 increases activity EXP 4-phenylenediamine results in increased activity of CASP3 protein CTD PMID:26784575 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CCL2 C-C motif chemokine ligand 2 increases secretion ISO 4-phenylenediamine results in increased secretion of CCL2 protein CTD PMID:22245253 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCL3L1 C-C motif chemokine ligand 3 like 1 increases expression EXP 4-phenylenediamine results in increased expression of CCL3L1 mRNA CTD PMID:20713136 Ensembl chr17:36,194,869...36,196,758 JBrowse link
G CCL4 C-C motif chemokine ligand 4 increases expression EXP 4-phenylenediamine results in increased expression of CCL4 mRNA CTD PMID:20713136 NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621
JBrowse link
G CCL5 C-C motif chemokine ligand 5 increases expression EXP 4-phenylenediamine results in increased expression of CCL5 mRNA CTD PMID:27585668 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
JBrowse link
G CCL7 C-C motif chemokine ligand 7 increases expression EXP 4-phenylenediamine results in increased expression of CCL7 mRNA CTD PMID:27585668 NCBI chr17:34,270,221...34,272,242
Ensembl chr17:34,270,221...34,272,242
JBrowse link
G CCR2 C-C motif chemokine receptor 2 decreases expression EXP 4-phenylenediamine results in decreased expression of CCR2 mRNA CTD PMID:19371601 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,744...46,360,940
Ensembl chr 3:46,353,744...46,360,940
JBrowse link
G CCR6 C-C motif chemokine receptor 6 decreases expression ISO 4-phenylenediamine results in decreased expression of CCR6 protein CTD PMID:15924226 NCBI chr 6:167,111,795...167,139,141
Ensembl chr 6:167,111,807...167,139,696
JBrowse link
G CD274 CD274 molecule increases expression EXP 4-phenylenediamine results in increased expression of CD274 protein CTD PMID:20488241 NCBI chr 9:5,450,542...5,470,554
Ensembl chr 9:5,450,503...5,470,566
JBrowse link
G CD86 CD86 molecule multiple interactions
increases expression
EXP bisindolylmaleimide I inhibits the reaction [4-phenylenediamine results in increased expression of CD86 protein] CTD PMID:12423654, PMID:19033392, PMID:19665512, PMID:20488241, PMID:24136171 NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP 4-phenylenediamine results in increased expression of CDKN1A mRNA CTD PMID:16314067 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CREM cAMP responsive element modulator increases expression EXP 4-phenylenediamine results in increased expression of CREM mRNA CTD PMID:19371601 NCBI chr10:35,126,830...35,212,958
Ensembl chr10:35,126,791...35,212,958
JBrowse link
G CSF2 colony stimulating factor 2 increases secretion ISO 4-phenylenediamine results in increased secretion of CSF2 protein CTD PMID:22245253 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 increases expression EXP 4-phenylenediamine results in increased expression of CXCL1 mRNA CTD PMID:20713136 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 decreases expression ISO 4-phenylenediamine results in decreased expression of CXCL10 mRNA CTD PMID:23445166 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497
JBrowse link
G CXCL14 C-X-C motif chemokine ligand 14 decreases expression EXP 4-phenylenediamine results in decreased expression of CXCL14 protein CTD PMID:31734321 NCBI chr 5:135,570,679...135,578,991
Ensembl chr 5:135,570,679...135,579,279
JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 increases expression ISO 4-phenylenediamine results in increased expression of CXCL2 protein CTD PMID:23178550 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression
multiple interactions
increases secretion
EXP 4-phenylenediamine results in increased expression of CXCL8 mRNA; 4-phenylenediamine results in increased expression of CXCL8 protein
bisindolylmaleimide I affects the reaction [4-phenylenediamine results in increased expression of CXCL8 protein]; SB 203580 affects the reaction [4-phenylenediamine results in increased secretion of CXCL8 protein]
CTD PMID:16099135, PMID:18494145, PMID:20491607, PMID:20713136, PMID:21920952, PMID:24136171, PMID:25617811, PMID:27965148, PMID:31734321 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 decreases expression ISO 4-phenylenediamine results in decreased expression of CXCR4 protein CTD PMID:15924226 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
JBrowse link
G CYTIP cytohesin 1 interacting protein increases expression EXP 4-phenylenediamine results in increased expression of CYTIP mRNA CTD PMID:19371601 NCBI chr 2:157,412,782...157,444,089
Ensembl chr 2:157,414,619...157,488,961
JBrowse link
G DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 increases expression EXP 4-phenylenediamine results in increased expression of DNAJB4 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr 1:77,979,175...78,017,964
Ensembl chr 1:77,979,175...78,017,964
JBrowse link
G DUSP1 dual specificity phosphatase 1 increases expression EXP 4-phenylenediamine results in increased expression of DUSP1 mRNA CTD PMID:16314067 NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195
JBrowse link
G FTH1 ferritin heavy chain 1 increases expression EXP 4-phenylenediamine results in increased expression of FTH1 mRNA CTD PMID:16314067 NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634
JBrowse link
G GABARAPL3 GABA type A receptor associated protein like 3 pseudogene increases expression EXP 4-phenylenediamine results in increased expression of GABARAPL3 mRNA CTD PMID:16314067 NCBI chr15:90,346,527...90,349,447
Ensembl chr15:90,348,844...90,349,197
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression EXP 4-phenylenediamine results in increased expression of GCLM mRNA CTD PMID:16314067, PMID:23999411, PMID:27965148 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GSTP1 glutathione S-transferase pi 1 increases metabolic processing EXP 4-phenylenediamine results in increased metabolism of GSTP1 protein CTD PMID:19469519 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G HAS1 hyaluronan synthase 1 increases expression EXP 4-phenylenediamine results in increased expression of HAS1 mRNA; 4-phenylenediamine results in increased expression of HAS1 protein CTD PMID:31226360 NCBI chr19:51,713,112...51,723,991
Ensembl chr19:51,713,112...51,723,994
Ensembl chr19:51,713,112...51,723,994
JBrowse link
G HAS2 hyaluronan synthase 2 increases expression EXP 4-phenylenediamine results in increased expression of HAS2 mRNA; 4-phenylenediamine results in increased expression of HAS2 protein CTD PMID:31226360 NCBI chr 8:121,612,116...121,641,440
Ensembl chr 8:121,612,116...121,641,440
JBrowse link
G HAS3 hyaluronan synthase 3 increases expression EXP 4-phenylenediamine results in increased expression of HAS3 mRNA; 4-phenylenediamine results in increased expression of HAS3 protein CTD PMID:31226360 NCBI chr16:69,105,653...69,118,719
Ensembl chr16:69,105,653...69,118,719
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha increases expression EXP 4-phenylenediamine results in increased expression of HIF1A mRNA CTD PMID:16314067 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
4-phenylenediamine results in increased expression of HMOX1 mRNA
BACH1 mRNA promotes the reaction [4-phenylenediamine results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA promotes the reaction [4-phenylenediamine results in increased expression of HMOX1 mRNA]
CTD PMID:16314067, PMID:19033392, PMID:20491607, PMID:20713136, PMID:23445166, PMID:25724174, PMID:26244607 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 increases expression EXP 4-phenylenediamine results in increased expression of HSPA6 mRNA CTD PMID:23999411 NCBI chr 1:161,524,540...161,526,894
Ensembl chr 1:161,524,540...161,526,894
JBrowse link
G HSPH1 heat shock protein family H (Hsp110) member 1 increases expression EXP 4-phenylenediamine results in increased expression of HSPH1 mRNA CTD PMID:23999411 NCBI chr13:31,134,973...31,162,388
Ensembl chr13:31,134,973...31,162,388
JBrowse link
G HTATIP2 HIV-1 Tat interactive protein 2 increases expression EXP 4-phenylenediamine results in increased expression of HTATIP2 mRNA CTD PMID:16314067 NCBI chr11:20,363,714...20,383,782
Ensembl chr11:20,363,685...20,383,783
JBrowse link
G HYAL1 hyaluronidase 1 increases expression EXP 4-phenylenediamine results in increased expression of HYAL1 mRNA CTD PMID:31226360 NCBI chr 3:50,299,889...50,312,951
Ensembl chr 3:50,299,890...50,312,381
JBrowse link
G IFNG interferon gamma increases expression
increases secretion
ISO 4-phenylenediamine results in increased expression of IFNG mRNA
4-phenylenediamine results in increased secretion of IFNG protein
CTD PMID:11531941, PMID:22245253 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL10 interleukin 10 increases expression ISO 4-phenylenediamine results in increased expression of IL10 mRNA CTD PMID:11531941 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL17F interleukin 17F increases expression ISO 4-phenylenediamine results in increased expression of IL17F mRNA CTD PMID:23445166 NCBI chr 6:52,236,681...52,245,689
Ensembl chr 6:52,236,681...52,244,500
Ensembl chr 6:52,236,681...52,244,500
JBrowse link
G IL18 interleukin 18 increases expression
multiple interactions
EXP 4-phenylenediamine results in increased expression of IL18 protein
PRDM1 protein promotes the reaction [4-phenylenediamine results in increased expression of IL18 protein]
CTD PMID:23063874, PMID:27585668 NCBI chr11:112,143,251...112,164,104
Ensembl chr11:112,143,253...112,164,096
JBrowse link
G IL1A interleukin 1 alpha increases expression ISO 4-phenylenediamine results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1B interleukin 1 beta increases expression EXP 4-phenylenediamine results in increased expression of IL1B mRNA CTD PMID:15140218 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 increases secretion ISO 4-phenylenediamine results in increased secretion of IL2 protein CTD PMID:22245253 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL4 interleukin 4 increases expression
increases secretion
ISO 4-phenylenediamine results in increased expression of IL4 mRNA
4-phenylenediamine results in increased secretion of IL4 protein
CTD PMID:11531941, PMID:22245253 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 increases secretion ISO 4-phenylenediamine results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G LRP6 LDL receptor related protein 6 decreases phosphorylation EXP 4-phenylenediamine results in decreased phosphorylation of LRP6 protein CTD PMID:26784575 NCBI chr12:12,116,025...12,267,044
Ensembl chr12:12,116,025...12,267,044
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation EXP 4-phenylenediamine results in increased phosphorylation of MAPK8 protein CTD PMID:23172806 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases phosphorylation EXP 4-phenylenediamine results in increased phosphorylation of MAPK9 protein CTD PMID:23172806 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099
JBrowse link
G ME1 malic enzyme 1 increases expression EXP 4-phenylenediamine results in increased expression of ME1 mRNA CTD PMID:16314067 NCBI chr 6:83,210,402...83,431,078
Ensembl chr 6:83,210,402...83,431,051
JBrowse link
G MLST8 MTOR associated protein, LST8 homolog decreases expression EXP 4-phenylenediamine results in decreased expression of MLST8 protein CTD PMID:26784575 NCBI chr16:2,204,628...2,209,453
Ensembl chr16:2,204,248...2,209,453
JBrowse link
G MT1H metallothionein 1H increases expression EXP 4-phenylenediamine results in increased expression of MT1H mRNA CTD PMID:16314067 NCBI chr16:56,669,814...56,671,129
Ensembl chr16:56,669,814...56,671,129
JBrowse link
G MT2A metallothionein 2A increases expression EXP 4-phenylenediamine results in increased expression of MT2A mRNA CTD PMID:16314067 NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497
JBrowse link
G MTOR mechanistic target of rapamycin kinase affects phosphorylation EXP 4-phenylenediamine affects the phosphorylation of MTOR protein CTD PMID:26784575 NCBI chr 1:11,106,535...11,273,497
Ensembl chr 1:11,106,535...11,262,551
JBrowse link
G NAT1 N-acetyltransferase 1 increases acetylation
multiple interactions
EXP NAT1 protein results in increased acetylation of 4-phenylenediamine
4-phenylenediamine results in decreased activity of and results in decreased expression of NAT1 protein
CTD PMID:15350687, PMID:20406859 NCBI chr 8:18,170,419...18,223,689
Ensembl chr 8:18,170,477...18,223,689
JBrowse link
G NAT2 N-acetyltransferase 2 affects response to substance EXP NAT2 gene polymorphism affects the susceptibility to 4-phenylenediamine CTD PMID:16533241 NCBI chr 8:18,386,585...18,401,219
Ensembl chr 8:18,391,282...18,401,218
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 increases expression
multiple interactions
EXP 4-phenylenediamine results in increased expression of NFE2L2 protein
NFE2L2 mRNA promotes the reaction [4-phenylenediamine results in increased expression of HMOX1 mRNA]
CTD PMID:19033392, PMID:26244607 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKBIA NFKB inhibitor alpha decreases phosphorylation EXP 4-phenylenediamine results in decreased phosphorylation of NFKBIA protein CTD PMID:26784575 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NINJ1 ninjurin 1 increases expression EXP 4-phenylenediamine results in increased expression of NINJ1 mRNA CTD PMID:16314067 NCBI chr 9:93,121,496...93,134,304
Ensembl chr 9:93,121,496...93,134,251
JBrowse link
G NLRP12 NLR family pyrin domain containing 12 increases expression
multiple interactions
decreases expression
EXP 4-phenylenediamine results in increased expression of NLRP12 mRNA
4-phenylenediamine promotes the reaction [[NLRP12 protein binds to NLRP3 protein binds to CASP1 protein] which binds to PYCARD protein]
4-phenylenediamine results in decreased expression of NLRP12 protein
CTD PMID:27585668, PMID:31276767 NCBI chr19:53,793,584...53,824,403
Ensembl chr19:53,793,603...53,824,394
Ensembl chr19:53,793,603...53,824,394
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 increases expression
multiple interactions
EXP 4-phenylenediamine results in increased expression of NLRP3 protein
4-phenylenediamine promotes the reaction [[NLRP12 protein binds to NLRP3 protein binds to CASP1 protein] which binds to PYCARD protein]
CTD PMID:31276767 NCBI chr 1:247,416,163...247,448,823
Ensembl chr 1:247,416,156...247,449,108
JBrowse link
G NLRX1 NLR family member X1 increases expression EXP 4-phenylenediamine results in increased expression of NLRX1 mRNA CTD PMID:27585668 NCBI chr11:119,168,334...119,184,016
Ensembl chr11:119,166,568...119,184,016
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression ISO
EXP
4-phenylenediamine results in increased expression of NQO1 mRNA CTD PMID:16314067, PMID:19033392, PMID:23445166, PMID:25724174 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G PGD phosphogluconate dehydrogenase increases expression EXP 4-phenylenediamine results in increased expression of PGD mRNA CTD PMID:16314067 NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511
JBrowse link
G PIGA phosphatidylinositol glycan anchor biosynthesis class A increases mutagenesis ISO 4-phenylenediamine results in increased mutagenesis of PIGA gene CTD PMID:30439388 NCBI chr  X:15,319,451...15,335,554
Ensembl chr  X:15,319,452...15,335,554
Ensembl chr  X:15,319,452...15,335,554
JBrowse link
G PIR pirin increases expression EXP 4-phenylenediamine results in increased expression of PIR mRNA CTD PMID:16314067 NCBI chr  X:15,384,799...15,493,333
Ensembl chr  X:15,384,799...15,493,564
JBrowse link
G PLIN2 perilipin 2 increases expression EXP 4-phenylenediamine results in increased expression of PLIN2 mRNA CTD PMID:16314067 NCBI chr 9:19,108,391...19,127,518
Ensembl chr 9:19,108,375...19,149,290
JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression EXP 4-phenylenediamine results in increased expression of PMAIP1 mRNA CTD PMID:16314067, PMID:20713136 NCBI chr18:59,899,996...59,904,305
Ensembl chr18:59,899,948...59,904,306
Ensembl chr18:59,899,948...59,904,306
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma increases expression EXP 4-phenylenediamine results in increased expression of PPARG mRNA CTD PMID:16314067 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PRDM1 PR/SET domain 1 multiple interactions
increases expression
EXP BAY 11-7085 inhibits the reaction [4-phenylenediamine results in increased expression of PRDM1 mRNA]; BAY 11-7085 inhibits the reaction [4-phenylenediamine results in increased expression of PRDM1 protein]; PRDM1 protein promotes the reaction [4-phenylenediamine results in increased expression of IL18 protein]
4-phenylenediamine results in increased expression of PRDM1 mRNA; 4-phenylenediamine results in increased expression of PRDM1 protein
CTD PMID:27585668, PMID:31276767 NCBI chr 6:106,046,729...106,109,938
Ensembl chr 6:105,993,463...106,109,939
JBrowse link
G PRDX3 peroxiredoxin 3 multiple interactions ISO 4-phenylenediamine promotes the reaction [Gentamicins results in increased expression of PRDX3 protein] CTD PMID:23626763 NCBI chr10:119,167,720...119,178,812
Ensembl chr10:119,167,720...119,178,812
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 increases expression EXP 4-phenylenediamine results in increased expression of PTGS1 mRNA CTD PMID:18571826 NCBI chr 9:122,369,906...122,395,703
Ensembl chr 9:122,370,530...122,395,703
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression EXP 4-phenylenediamine results in increased expression of PTGS2 mRNA CTD PMID:18571826, PMID:19371601, PMID:20713136 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G PYCARD PYD and CARD domain containing multiple interactions
increases expression
EXP 4-phenylenediamine promotes the reaction [[NLRP12 protein binds to NLRP3 protein binds to CASP1 protein] which binds to PYCARD protein]
4-phenylenediamine results in increased expression of PYCARD protein
CTD PMID:31276767 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
EXP aristolochic acid I inhibits the reaction [4-phenylenediamine results in increased phosphorylation of RELA protein]; TLR4 protein promotes the reaction [4-phenylenediamine results in increased phosphorylation of RELA protein] CTD PMID:31226360 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RGS1 regulator of G protein signaling 1 increases expression EXP 4-phenylenediamine results in increased expression of RGS1 mRNA CTD PMID:20713136 NCBI chr 1:192,575,773...192,580,024
Ensembl chr 1:192,575,763...192,580,024
JBrowse link
G RICTOR RPTOR independent companion of MTOR complex 2 decreases expression EXP 4-phenylenediamine results in decreased expression of RICTOR protein CTD PMID:26784575 NCBI chr 5:38,937,920...39,074,421
Ensembl chr 5:38,937,920...39,074,399
JBrowse link
G RIT1 Ras like without CAAX 1 increases expression EXP 4-phenylenediamine results in increased expression of RIT1 mRNA CTD PMID:16314067 NCBI chr 1:155,897,808...155,911,349
Ensembl chr 1:155,897,808...155,911,404
JBrowse link
G RPTOR regulatory associated protein of MTOR complex 1 decreases expression EXP 4-phenylenediamine results in decreased expression of RPTOR protein CTD PMID:26784575 NCBI chr17:80,544,838...80,966,368
Ensembl chr17:80,544,819...80,966,371
JBrowse link
G S100P S100 calcium binding protein P increases expression EXP 4-phenylenediamine results in increased expression of S100P mRNA CTD PMID:16314067 NCBI chr 4:6,693,878...6,697,170
Ensembl chr 4:6,693,878...6,697,170
JBrowse link
G SI sucrase-isomaltase increases expression EXP 4-phenylenediamine results in increased expression of SI mRNA CTD PMID:16314067 NCBI chr 3:164,978,898...165,078,496
Ensembl chr 3:164,978,898...165,078,496
JBrowse link
G SLAMF1 signaling lymphocytic activation molecule family member 1 decreases expression EXP 4-phenylenediamine results in decreased expression of SLAMF1 mRNA CTD PMID:20713136 NCBI chr 1:160,608,100...160,647,311
Ensembl chr 1:160,608,106...160,647,295
JBrowse link
G SLC2A3 solute carrier family 2 member 3 increases expression EXP 4-phenylenediamine results in increased expression of SLC2A3 mRNA CTD PMID:19371601 NCBI chr12:7,919,230...7,936,187
Ensembl chr12:7,919,230...7,936,187
JBrowse link
G SPTA1 spectrin alpha, erythrocytic 1 increases expression EXP 4-phenylenediamine results in increased expression of SPTA1 mRNA CTD PMID:16314067 NCBI chr 1:158,610,498...158,686,715
Ensembl chr 1:158,610,704...158,686,715
JBrowse link
G TLR4 toll like receptor 4 increases expression
multiple interactions
EXP 4-phenylenediamine results in increased expression of TLR4 mRNA; 4-phenylenediamine results in increased expression of TLR4 protein
TLR4 protein promotes the reaction [4-phenylenediamine results in increased phosphorylation of RELA protein]
CTD PMID:31226360 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TNF tumor necrosis factor affects response to substance
increases secretion
EXP
ISO
TNF gene polymorphism affects the susceptibility to 4-phenylenediamine
4-phenylenediamine results in increased secretion of TNF protein
CTD PMID:18384449, PMID:22245253 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFAIP3 TNF alpha induced protein 3 increases expression EXP 4-phenylenediamine results in increased expression of TNFAIP3 mRNA CTD PMID:20713136 NCBI chr 6:137,866,317...137,883,312
Ensembl chr 6:137,867,214...137,883,312
JBrowse link
G TNFAIP6 TNF alpha induced protein 6 increases expression EXP 4-phenylenediamine results in increased expression of TNFAIP6 mRNA CTD PMID:20713136 NCBI chr 2:151,357,592...151,380,046
Ensembl chr 2:151,357,592...151,380,046
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression ISO 4-phenylenediamine results in increased expression of TXNRD1 mRNA CTD PMID:23445166 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G VEGFA vascular endothelial growth factor A increases expression EXP 4-phenylenediamine results in increased expression of VEGFA protein CTD PMID:9390328, PMID:25617811 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
2',7'-bis-(2-carboxyethyl)carboxyfluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC4 ATP binding cassette subfamily C member 4 multiple interactions EXP Mefloquine inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] CTD PMID:16004972 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 increases export
multiple interactions
EXP ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein
daidzein inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; hesperetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; naringenin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; Quercetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; resveratrol inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; Silymarin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]
CTD PMID:16156793 NCBI chr 3:183,919,934...184,018,010
Ensembl chr 3:183,919,934...184,017,939
JBrowse link
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
increases transport
EXP
ISO
abamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride
abamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
CTD PMID:25865432 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCB11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
EXP bisbenzimide ethoxide trihydrochloride inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
bisbenzimide ethoxide trihydrochloride results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 multiple interactions
increases transport
EXP
ISO
abamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride] CTD PMID:25865432 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) decreases abundance
decreases export
decreases activity
multiple interactions
increases export
increases transport
EXP ABCG2 protein results in decreased abundance of bisbenzimide ethoxide trihydrochloride
ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride
bisbenzimide ethoxide trihydrochloride results in decreased activity of ABCG2 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; [MYC protein results in increased expression of ABCG2 protein] which results in increased export of bisbenzimide ethoxide trihydrochloride; Cimetidine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Cyclosporine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; danofloxacin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Genistein inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Genistein promotes the reaction [ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride]; Methotrexate inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Nitrofurantoin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Reserpine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Tobacco Smoke Pollution inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; verlukast inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
CTD PMID:12869632, PMID:19239227, PMID:26850786, PMID:26907376, PMID:27450509, PMID:27475308 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628
JBrowse link
G KEAP1 kelch like ECH associated protein 1 decreases export EXP KEAP1 protein results in decreased export of bisbenzimide ethoxide trihydrochloride CTD PMID:25841332 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions EXP [MYC protein results in increased expression of ABCG2 protein] which results in increased export of bisbenzimide ethoxide trihydrochloride CTD PMID:19239227 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
2,6-dichloroindophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2L1 BCL2 like 1 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in decreased expression of BCL2L1 mRNA CTD PMID:21034357 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G CCL4 C-C motif chemokine ligand 4 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CCL4 mRNA CTD PMID:21034357 NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CDKN1A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CDKN1A protein CTD PMID:21034357 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CNTF ciliary neurotrophic factor multiple interactions EXP 2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; 2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]] CTD PMID:19635391 NCBI chr11:58,622,665...58,625,733
Ensembl chr11:58,622,665...58,625,733
JBrowse link
G CRYAB crystallin alpha B multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CRYAB mRNA CTD PMID:21034357 NCBI chr11:111,908,564...111,923,740
Ensembl chr11:111,908,564...111,923,722
JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CXCL10 mRNA CTD PMID:21034357 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497
JBrowse link
G EGR1 early growth response 1 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of EGR1 mRNA CTD PMID:21034357 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G EPHX2 epoxide hydrolase 2 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of EPHX2 mRNA CTD PMID:21034357 NCBI chr 8:27,491,143...27,597,559
Ensembl chr 8:27,490,781...27,545,564
JBrowse link
G FASLG Fas ligand multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of FASLG mRNA CTD PMID:21034357 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GADD45A mRNA CTD PMID:21034357 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
JBrowse link
G GDF15 growth differentiation factor 15 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GDF15 mRNA CTD PMID:21034357 NCBI chr19:18,382,170...18,389,176
Ensembl chr19:18,374,731...18,389,176
JBrowse link
G GSTM3 glutathione S-transferase mu 3 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GSTM3 mRNA CTD PMID:21034357 NCBI chr 1:109,733,937...109,741,038
Ensembl chr 1:109,733,932...109,741,038
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HMOX1 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HMOX1 protein CTD PMID:21034357 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA1A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA1A protein CTD PMID:21034357 NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946
JBrowse link
G HSPA2 heat shock protein family A (Hsp70) member 2 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA2 mRNA CTD PMID:21034357 NCBI chr14:64,540,741...64,543,237
Ensembl chr14:64,535,905...64,546,173
JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA6 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA6 protein CTD PMID:21034357 NCBI chr 1:161,524,540...161,526,894
Ensembl chr 1:161,524,540...161,526,894
JBrowse link
G LTA lymphotoxin alpha multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of LTA mRNA CTD PMID:21034357 NCBI chr 6:31,560,550...31,574,324
Ensembl chr 6:31,572,054...31,574,324
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of NOS2 mRNA CTD PMID:21034357 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases reduction
increases response to substance
EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in decreased expression of BCL2L1 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CCL4 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CDKN1A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CDKN1A protein; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CRYAB mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CXCL10 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of EGR1 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of EPHX2 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of FASLG mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GADD45A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GDF15 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GSTM3 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HMOX1 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HMOX1 protein; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA1A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA1A protein; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA2 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA6 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA6 protein; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of LTA mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of NOS2 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of TNF mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased phosphorylation of TP53 protein; Carbamazepine inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; Diclofenac inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; Dicumarol inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; Mefenamic Acid inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; NQO1 protein inhibits the reaction [2,6-Dichloroindophenol results in decreased abundance of Glutathione]; NQO1 protein polymorphism promotes the reaction [2,6-Dichloroindophenol results in decreased abundance of Glutathione]; Tacrine inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]
NQO1 protein polymorphism results in increased susceptibility to 2,6-Dichloroindophenol
CTD PMID:21034357, PMID:29281794 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions
increases reduction
EXP [NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of 2,6-Dichloroindophenol; [NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of 2,6-Dichloroindophenol; resveratrol inhibits the reaction [NQO2 protein results in increased reduction of 2,6-Dichloroindophenol]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of 2,6-Dichloroindophenol] CTD PMID:20399199, PMID:29281794 NCBI chr 6:2,999,816...3,019,876
Ensembl chr 6:2,987,987...3,021,850
Ensembl chr 6:2,987,987...3,021,850
JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions EXP 2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]] CTD PMID:19635391 NCBI chr 2:190,968,989...191,014,197
Ensembl chr 2:190,908,460...191,020,960
Ensembl chr 2:190,908,460...191,020,960
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions EXP 2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]] CTD PMID:19635391 NCBI chr17:42,313,324...42,388,502
Ensembl chr17:42,313,324...42,388,482
Ensembl chr17:42,313,324...42,388,482
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of TNF mRNA CTD PMID:21034357 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased phosphorylation of TP53 protein CTD PMID:21034357 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
2-nitro-p-phenylenediamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACMSD aminocarboxymuconate semialdehyde decarboxylase decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of ACMSD mRNA CTD PMID:17070881 NCBI chr 2:134,838,319...134,902,906
Ensembl chr 2:134,838,616...134,902,034
JBrowse link
G ACSL3 acyl-CoA synthetase long chain family member 3 decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of ACSL3 mRNA CTD PMID:17070881 NCBI chr 2:222,861,036...222,944,639
Ensembl chr 2:222,860,942...222,944,639
JBrowse link
G AEN apoptosis enhancing nuclease increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of AEN mRNA CTD PMID:17070881 NCBI chr15:88,604,601...88,632,281
Ensembl chr15:88,621,337...88,632,281
JBrowse link
G AKR7A3 aldo-keto reductase family 7 member A3 increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of AKR7A3 mRNA CTD PMID:17070881 NCBI chr 1:19,274,229...19,289,362
Ensembl chr 1:19,282,573...19,288,770
JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of ALDH1A1 mRNA CTD PMID:17070881 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442
JBrowse link
G APOA2 apolipoprotein A2 decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of APOA2 mRNA CTD PMID:17070881 NCBI chr 1:161,222,292...161,223,628
Ensembl chr 1:161,222,292...161,223,631
JBrowse link
G APOA4 apolipoprotein A4 decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of APOA4 mRNA CTD PMID:17070881 NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304
JBrowse link
G APOC3 apolipoprotein C3 decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of APOC3 mRNA CTD PMID:17070881 NCBI chr11:116,829,907...116,833,072
Ensembl chr11:116,829,706...116,833,072
JBrowse link
G ATP6V1D ATPase H+ transporting V1 subunit D increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of ATP6V1D mRNA CTD PMID:17070881 NCBI chr14:67,337,872...67,359,804
Ensembl chr14:67,294,371...67,360,265
JBrowse link
G BAX BCL2 associated X, apoptosis regulator decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of BAX mRNA CTD PMID:17070881 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BTG2 BTG anti-proliferation factor 2 decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of BTG2 mRNA CTD PMID:17070881 NCBI chr 1:203,305,519...203,309,602
Ensembl chr 1:203,305,491...203,309,602
JBrowse link
G C7 complement C7 decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of C7 mRNA CTD PMID:17070881 NCBI chr 5:40,909,497...40,984,643
Ensembl chr 5:40,909,497...40,984,643
JBrowse link
G CBLC Cbl proto-oncogene C decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of CBLC mRNA CTD PMID:17070881 NCBI chr19:44,777,855...44,800,652
Ensembl chr19:44,777,869...44,800,652
JBrowse link
G CCNG1 cyclin G1 increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of CCNG1 mRNA CTD PMID:17070881 NCBI chr 5:163,437,571...163,448,199
Ensembl chr 5:163,437,569...163,446,151
JBrowse link
G CD276 CD276 molecule increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of CD276 mRNA CTD PMID:17070881 NCBI chr15:73,683,966...73,714,518
Ensembl chr15:73,683,966...73,714,514
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of CDKN1A mRNA CTD PMID:17070881 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CPQ carboxypeptidase Q decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of CPQ mRNA CTD PMID:17070881 NCBI chr 8:96,645,242...97,143,501
Ensembl chr 8:96,645,242...97,149,654
JBrowse link
G CRYAB crystallin alpha B increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of CRYAB mRNA CTD PMID:17070881 NCBI chr11:111,908,564...111,923,740
Ensembl chr11:111,908,564...111,923,722
JBrowse link
G DDAH1 dimethylarginine dimethylaminohydrolase 1 increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of DDAH1 mRNA CTD PMID:17070881 NCBI chr 1:85,318,485...85,578,274
Ensembl chr 1:85,318,481...85,578,363
JBrowse link
G EPCAM epithelial cell adhesion molecule increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of EPCAM mRNA CTD PMID:17070881 NCBI chr 2:47,369,311...47,387,020
Ensembl chr 2:47,345,158...47,387,601
JBrowse link
G EPHX1 epoxide hydrolase 1 increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of EPHX1 mRNA CTD PMID:17070881 NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,092...225,845,563
JBrowse link
G FAS Fas cell surface death receptor increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of FAS mRNA CTD PMID:17070881 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FHIT fragile histidine triad diadenosine triphosphatase increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of FHIT mRNA CTD PMID:17070881 NCBI chr 3:59,747,277...61,251,452
Ensembl chr 3:59,747,277...61,251,459
JBrowse link
G GRIA3 glutamate ionotropic receptor AMPA type subunit 3 increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of GRIA3 mRNA CTD PMID:17070881 NCBI chr  X:123,184,278...123,490,915
Ensembl chr  X:123,184,153...123,490,915
JBrowse link
G GSTM1 glutathione S-transferase mu 1 increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of GSTM1 mRNA CTD PMID:17070881 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
JBrowse link
G HSD17B6 hydroxysteroid 17-beta dehydrogenase 6 decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of HSD17B6 mRNA CTD PMID:17070881 NCBI chr12:56,752,449...56,787,790
Ensembl chr12:56,752,161...56,787,790
JBrowse link
G IL2RA interleukin 2 receptor subunit alpha decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of IL2RA mRNA CTD PMID:17070881 NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370
JBrowse link
G MGMT O-6-methylguanine-DNA methyltransferase decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of MGMT mRNA CTD PMID:17070881 NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983
JBrowse link
G NUPR1 nuclear protein 1, transcriptional regulator increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of NUPR1 mRNA CTD PMID:17070881 NCBI chr16:28,532,708...28,538,974
Ensembl chr16:28,532,708...28,539,174
Ensembl chr16:28,532,708...28,539,174
JBrowse link
G PHLDA3 pleckstrin homology like domain family A member 3 decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of PHLDA3 mRNA CTD PMID:17070881 NCBI chr 1:201,464,278...201,469,188
Ensembl chr 1:201,464,278...201,469,237
JBrowse link
G RHOBTB2 Rho related BTB domain containing 2 increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of RHOBTB2 mRNA CTD PMID:17070881 NCBI chr 8:22,987,251...23,020,199
Ensembl chr 8:22,987,417...23,020,199
JBrowse link
G SERPINA7 serpin family A member 7 increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of SERPINA7 mRNA CTD PMID:17070881 NCBI chr  X:106,032,435...106,038,727
Ensembl chr  X:106,032,435...106,038,727
JBrowse link
G SLC16A10 solute carrier family 16 member 10 decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of SLC16A10 mRNA CTD PMID:17070881 NCBI chr 6:111,087,503...111,231,194
Ensembl chr 6:111,087,503...111,231,194
JBrowse link
G SPINK1 serine peptidase inhibitor Kazal type 1 decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of SPINK1 mRNA CTD PMID:17070881 NCBI chr 5:147,824,582...147,839,196
Ensembl chr 5:147,824,568...147,831,786
JBrowse link
G SUGCT succinyl-CoA:glutarate-CoA transferase increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of SUGCT mRNA CTD PMID:17070881 NCBI chr 7:40,134,887...40,860,763
Ensembl chr 7:40,135,005...40,860,763
Ensembl chr 7:40,135,005...40,860,763
JBrowse link
G SULF2 sulfatase 2 decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of SULF2 mRNA CTD PMID:17070881 NCBI chr20:47,654,569...47,786,616
Ensembl chr20:47,656,348...47,786,616
JBrowse link
G SULT2A1 sulfotransferase family 2A member 1 increases expression ISO 2-nitro-4-phenylenediamine results in increased expression of SULT2A1 mRNA CTD PMID:17070881 NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315
JBrowse link
G ZMAT3 zinc finger matrin-type 3 decreases expression ISO 2-nitro-4-phenylenediamine results in decreased expression of ZMAT3 mRNA CTD PMID:17070881 NCBI chr 3:179,017,223...179,072,513
Ensembl chr 3:178,960,121...179,072,215
JBrowse link
3,4-dihydrocoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDIT3 DNA damage inducible transcript 3 affects expression ISO 3,4-dihydrocoumarin affects the expression of DDIT3 mRNA CTD PMID:22016648 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DNAJA2 DnaJ heat shock protein family (Hsp40) member A2 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of DNAJA2 mRNA CTD PMID:22016648 NCBI chr16:46,955,362...46,973,674
Ensembl chr16:46,955,362...46,973,674
JBrowse link
G EGF epidermal growth factor increases expression ISO 3,4-dihydrocoumarin results in increased expression of EGF mRNA CTD PMID:22016648 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G EPHX1 epoxide hydrolase 1 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of EPHX1 mRNA CTD PMID:22016648 NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,092...225,845,563
JBrowse link
G HSD17B4 hydroxysteroid 17-beta dehydrogenase 4 increases expression ISO 3,4-dihydrocoumarin results in increased expression of HSD17B4 mRNA CTD PMID:22016648 NCBI chr 5:119,452,497...119,542,332
Ensembl chr 5:119,452,473...119,637,199
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of HSP90AB1 mRNA CTD PMID:22016648 NCBI chr 6:44,246,194...44,253,883
Ensembl chr 6:44,246,166...44,253,888
JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A increases expression ISO 3,4-dihydrocoumarin results in increased expression of HSPA1A mRNA CTD PMID:22016648 NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946
JBrowse link
G OAT ornithine aminotransferase decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of OAT mRNA CTD PMID:22016648 NCBI chr10:124,397,303...124,418,923
Ensembl chr10:124,397,303...124,418,976
JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of PCK1 mRNA CTD PMID:22016648 NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121
JBrowse link
G PON1 paraoxonase 1 affects metabolic processing EXP PON1 SNP affects the metabolism of 3,4-dihydrocoumarin CTD PMID:25027835 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532
JBrowse link
G PRDX1 peroxiredoxin 1 increases expression ISO 3,4-dihydrocoumarin results in increased expression of PRDX1 mRNA CTD PMID:22016648 NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,511,036...45,523,047
JBrowse link
G PRDX3 peroxiredoxin 3 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of PRDX3 mRNA CTD PMID:22016648 NCBI chr10:119,167,720...119,178,812
Ensembl chr10:119,167,720...119,178,812
JBrowse link
G PSMB8 proteasome 20S subunit beta 8 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of PSMB8 mRNA CTD PMID:22016648 NCBI chr 6:32,840,717...32,844,679
Ensembl chr 6:32,840,717...32,844,679
JBrowse link
G PTPMT1 protein tyrosine phosphatase mitochondrial 1 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of PTPMT1 mRNA CTD PMID:22016648 NCBI chr11:47,565,599...47,573,461
Ensembl chr11:47,565,430...47,573,461
JBrowse link
G RBP4 retinol binding protein 4 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of RBP4 mRNA CTD PMID:22016648 NCBI chr10:93,591,694...93,601,744
Ensembl chr10:93,591,687...93,601,744
JBrowse link
G SOD1 superoxide dismutase 1 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of SOD1 mRNA CTD PMID:22016648 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of TIMP2 mRNA CTD PMID:22016648 NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387
JBrowse link
G TUBB tubulin beta class I decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of TUBB5 mRNA CTD PMID:22016648 NCBI chr 6:30,720,352...30,725,422
Ensembl chr 6:30,720,352...30,725,426
JBrowse link
3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALB albumin affects binding EXP Alizarin Red S binds to ALB protein CTD PMID:18968587 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases activity EXP thiazolyl blue results in decreased activity of ABCB1 protein CTD PMID:15451006 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ACO2 aconitase 2 multiple interactions ISO [Calcium results in increased activity of ACO2 protein] which results in increased reduction of thiazolyl blue; [Potassium deficiency results in decreased activity of ACO2 protein] which results in decreased reduction of thiazolyl blue CTD PMID:12548706 NCBI chr22:41,468,756...41,528,979
Ensembl chr22:41,469,117...41,528,989
JBrowse link
G CASP3 caspase 3 increases activity EXP thiazolyl blue results in increased activity of CASP3 protein CTD PMID:22401948 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 increases activity EXP thiazolyl blue results in increased activity of CASP8 protein CTD PMID:22401948 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 increases reduction
multiple interactions
EXP NQO2 protein results in increased reduction of thiazolyl blue
resveratrol inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue]
CTD PMID:29281794 NCBI chr 6:2,999,816...3,019,876
Ensembl chr 6:2,987,987...3,021,850
Ensembl chr 6:2,987,987...3,021,850
JBrowse link
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DNMT1 DNA methyltransferase 1 decreases activity EXP lac dye results in decreased activity of DNMT1 protein CTD PMID:23839987 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,345...10,231,286
JBrowse link
5(6)-carboxy-2',7'-dichlorofluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 affects transport
multiple interactions
increases export
increases transport
ISO
EXP
ABCC2 protein affects the transport of 5(6)-carboxy-2',7'-dichlorofluorescein
4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein; Ascorbic Acid inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]]; Ascorbic Acid promotes the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Benzbromarone inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Calcium deficiency inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; cyanoginosin LR inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Cyclosporine inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; microcystin RR inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; microcystin-LF inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Probenecid inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog]; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Tobacco Smoke Pollution inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog]
ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein; ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog
[ABCC2 gene mutant form results in increased expression of ABCC3 protein] which results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein; ABCC2 gene mutant form inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]
CTD PMID:19326901, PMID:21240898, PMID:21341280, PMID:23562342, PMID:24907646, PMID:24909372, PMID:24973091, PMID:25862123, PMID:27450509, PMID:31348918 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 multiple interactions
increases transport
ISO
EXP
[ABCC2 gene mutant form results in increased expression of ABCC3 protein] which results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein
Benzbromarone inhibits the reaction [ABCC3 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]
CTD PMID:24907646, PMID:31348918 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253
JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 multiple interactions
increases transport
EXP Benzbromarone inhibits the reaction [ABCC5 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein] CTD PMID:31348918 NCBI chr 3:183,919,934...184,018,010
Ensembl chr 3:183,919,934...184,017,939
JBrowse link
5-carboxyfluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A8 solute carrier family 22 member 8 multiple interactions
increases transport
EXP quercetin 3'-sulfate inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide analog inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein] CTD PMID:21244849 NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841
JBrowse link
5-chloromethylfluorescein diacetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 multiple interactions EXP ABCC2 protein affects the transport of [5-chloromethylfluorescein co-treated with Glutathione] CTD PMID:16049127 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
6-carboxyfluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 increases export EXP ABCC1 protein results in increased export of 6-carboxyfluorescein CTD PMID:17940500 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 affects export
multiple interactions
EXP ABCC2 protein affects the export of 6-carboxyfluorescein
Probenecid inhibits the reaction [ABCC2 protein affects the export of 6-carboxyfluorescein]
CTD PMID:11477083 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G SLC22A11 solute carrier family 22 member 11 multiple interactions
increases uptake
increases import
EXP glutaric acid promotes the reaction [SLC22A11 protein results in increased import of 6-carboxyfluorescein]; p-Aminohippuric Acid promotes the reaction [SLC22A11 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A11 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A11 protein results in increased uptake of 6-carboxyfluorescein]; Sulpiride inhibits the reaction [SLC22A11 protein results in increased uptake of 6-carboxyfluorescein] CTD PMID:20639259, PMID:28597291 NCBI chr11:64,555,847...64,572,875
Ensembl chr11:64,555,690...64,572,875
JBrowse link
G SLC22A6 solute carrier family 22 member 6 multiple interactions
increases import
EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; glutaric acid promotes the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein] CTD PMID:28629854 NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967
Ensembl chr11:62,936,385...62,984,967
JBrowse link
G SLC22A8 solute carrier family 22 member 8 increases import
multiple interactions
EXP SLC22A8 protein results in increased import of 6-carboxyfluorescein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; 2-amino-9H-pyrido(2,3-b)indole promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Cadmium Chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; glutaric acid promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; lead chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; sodium arsenate promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]
CTD PMID:28629854 NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841
JBrowse link
9-aminoacridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Cartwright blood group) affects binding EXP Aminacrine binds to ACHE protein CTD PMID:31176713 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases response to substance EXP BAX protein results in increased susceptibility to Aminacrine CTD PMID:16177561 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G H2AX H2A.X variant histone decreases phosphorylation
multiple interactions
EXP Aminacrine results in decreased phosphorylation of H2AX protein
[Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]
CTD PMID:26928355 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,854...119,095,467
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha increases activity EXP Aminacrine results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G MDC1 mediator of DNA damage checkpoint 1 multiple interactions EXP [Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; Aminacrine inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein] CTD PMID:26928355 NCBI chr 6:30,699,807...30,717,988
Ensembl chr 6:30,699,807...30,717,447
JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 multiple interactions EXP Aminacrine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Aminacrine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP Aminacrine results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
acid red 29 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALB albumin affects binding EXP chromotrope 2R binds to ALB protein CTD PMID:19347248 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
acridine orange term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator increases response to substance EXP BAX protein results in increased susceptibility to Acridine Orange CTD PMID:16177561 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions EXP [Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA CTD PMID:16814760 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP Acridine Orange results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
acridine orange free base term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator increases response to substance EXP BAX protein results in increased susceptibility to Acridine Orange CTD PMID:16177561 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions EXP [Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA CTD PMID:16814760 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP Acridine Orange results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
alizarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases activity EXP alizarin results in decreased activity of CYP1A1 protein CTD PMID:12379470 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity EXP alizarin results in decreased activity of CYP1A2 protein CTD PMID:12379470 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity EXP alizarin results in decreased activity of CYP1B1 protein CTD PMID:12379470 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 decreases activity EXP alizarin results in decreased activity of CYP2A6 protein CTD PMID:12379470 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity EXP alizarin results in decreased activity of CYP2E1 protein CTD PMID:12379470 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP alizarin binds to and results in increased activity of ESR1 protein CTD PMID:20707409 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation EXP UGT1A1 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 increases glucuronidation EXP UGT1A10 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 2:233,636,477...233,773,305
Ensembl chr 2:233,636,454...233,773,305
JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 2:233,681,938...233,773,299
Ensembl chr 2:233,681,938...233,773,299
JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation EXP UGT1A8 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 2:233,617,645...233,773,299
Ensembl chr 2:233,617,645...233,773,310
JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation EXP UGT1A9 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300
JBrowse link
G UGT2B15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of alizarin CTD PMID:7835232 NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652
JBrowse link
auramine O term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 increases expression
multiple interactions
EXP Benzophenoneidum results in increased expression of ALDH1A1 protein
ALDH1A1 protein promotes the reaction [Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein]
CTD PMID:28722353 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442
JBrowse link
G ANO6 anoctamin 6 increases expression EXP Benzophenoneidum results in increased expression of ANO6 protein CTD PMID:28722353 NCBI chr12:45,216,033...45,440,404
Ensembl chr12:45,215,987...45,440,404
JBrowse link
G ARAF A-Raf proto-oncogene, serine/threonine kinase increases expression EXP Benzophenoneidum results in increased expression of ARAF protein CTD PMID:28722353 NCBI chr  X:47,561,205...47,571,908
Ensembl chr  X:47,561,100...47,571,920
JBrowse link
G ATP6AP2 ATPase H+ transporting accessory protein 2 increases expression EXP Benzophenoneidum results in increased expression of ATP6AP2 protein CTD PMID:28722353 NCBI chr  X:40,580,970...40,606,848
Ensembl chr  X:40,579,372...40,606,848
JBrowse link
G CCDC22 coiled-coil domain containing 22 increases expression EXP Benzophenoneidum results in increased expression of CCDC22 protein CTD PMID:28722353 NCBI chr  X:49,235,470...49,250,526
Ensembl chr  X:49,235,470...49,250,520
JBrowse link
G CCDC39 coiled-coil domain containing 39 increases expression EXP Benzophenoneidum results in increased expression of CCDC39 protein CTD PMID:28722353 NCBI chr 3:180,614,008...180,679,489
Ensembl chr 3:180,614,008...180,870,933
Ensembl chr 3:180,614,008...180,870,933
JBrowse link
G CD44 CD44 molecule (Indian blood group) increases expression EXP Benzophenoneidum results in increased expression of CD44 protein CTD PMID:28722353 NCBI chr11:35,139,168...35,232,402
Ensembl chr11:35,138,882...35,232,402
Ensembl chr11:35,138,882...35,232,402
JBrowse link
G CHTF18 chromosome transmission fidelity factor 18 increases expression EXP Benzophenoneidum results in increased expression of CHTF18 protein CTD PMID:28722353 NCBI chr16:788,620...798,074
Ensembl chr16:788,046...800,737
JBrowse link
G COMMD1 copper metabolism domain containing 1 increases expression EXP Benzophenoneidum results in increased expression of COMMD1 protein CTD PMID:28722353 NCBI chr 2:61,888,391...62,141,186
Ensembl chr 2:61,888,724...62,147,247
JBrowse link
G COPS7B COP9 signalosome subunit 7B increases expression EXP Benzophenoneidum results in increased expression of COPS7B protein CTD PMID:28722353 NCBI chr 2:231,781,671...231,809,253
Ensembl chr 2:231,781,671...231,809,254
JBrowse link
G CUL3 cullin 3 increases expression EXP Benzophenoneidum results in increased expression of CUL3 protein CTD PMID:28722353 NCBI chr 2:224,470,150...224,585,363
Ensembl chr 2:224,470,150...224,585,397
JBrowse link
G DYNLT1 dynein light chain Tctex-type 1 increases expression EXP Benzophenoneidum results in increased expression of DYNLT1 protein CTD PMID:28722353 NCBI chr 6:158,636,474...158,644,743
Ensembl chr 6:158,636,474...158,644,743
JBrowse link
G EIF4G3 eukaryotic translation initiation factor 4 gamma 3 increases expression EXP Benzophenoneidum results in increased expression of EIF4G3 protein CTD PMID:28722353 NCBI chr 1:20,806,292...21,176,897
Ensembl chr 1:20,806,292...21,176,888
JBrowse link
G FASTKD2 FAST kinase domains 2 increases expression EXP Benzophenoneidum results in increased expression of FASTKD2 protein CTD PMID:28722353 NCBI chr 2:206,765,606...206,796,189
Ensembl chr 2:206,765,357...206,796,189
JBrowse link
G HOOK3 hook microtubule tethering protein 3 increases expression EXP Benzophenoneidum results in increased expression of HOOK3 protein CTD PMID:28722353 NCBI chr 8:42,896,978...43,030,535
Ensembl chr 8:42,896,946...43,030,535
JBrowse link
G HSD17B7 hydroxysteroid 17-beta dehydrogenase 7 increases expression EXP Benzophenoneidum results in increased expression of HSD17B7 protein CTD PMID:28722353 NCBI chr 1:162,790,702...162,812,823
Ensembl chr 1:162,790,702...162,812,817
JBrowse link
G HTT huntingtin increases expression EXP Benzophenoneidum results in increased expression of HTT protein CTD PMID:28722353 NCBI chr 4:3,074,681...3,243,960
Ensembl chr 4:3,041,422...3,243,960
JBrowse link
G IQGAP3 IQ motif containing GTPase activating protein 3 increases expression EXP Benzophenoneidum results in increased expression of IQGAP3 protein CTD PMID:28722353 NCBI chr 1:156,525,405...156,572,605
Ensembl chr 1:156,525,405...156,572,604
JBrowse link
G KIFAP3 kinesin associated protein 3 increases expression EXP Benzophenoneidum results in increased expression of KIFAP3 protein CTD PMID:28722353 NCBI chr 1:169,921,326...170,085,203
Ensembl chr 1:169,921,326...170,085,208
JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions EXP ALDH1A1 protein promotes the reaction [Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein]; Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein CTD PMID:28722353 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779
JBrowse link
G MAP2K4 mitogen-activated protein kinase kinase 4 increases expression EXP Benzophenoneidum results in increased expression of MAP2K4 protein CTD PMID:28722353 NCBI chr17:12,020,822...12,143,828
Ensembl chr17:12,020,829...12,143,830
JBrowse link
G MBD3 methyl-CpG binding domain protein 3 increases expression EXP Benzophenoneidum results in increased expression of MBD3 protein CTD PMID:28722353 NCBI chr19:1,573,596...1,592,865
Ensembl chr19:1,573,596...1,592,865
JBrowse link
G NOA1 nitric oxide associated 1 increases expression EXP Benzophenoneidum results in increased expression of NOA1 protein CTD PMID:28722353 NCBI chr 4:56,963,350...56,977,606
Ensembl chr 4:56,963,350...56,977,606
JBrowse link
G NUP62 nucleoporin 62 increases expression EXP Benzophenoneidum results in increased expression of NUP62 protein CTD PMID:28722353 NCBI chr19:49,906,825...49,929,504
Ensembl chr19:49,906,825...49,929,763
JBrowse link
G PLCG1 phospholipase C gamma 1 increases expression EXP Benzophenoneidum results in increased expression of PLCG1 protein CTD PMID:28722353 NCBI chr20:41,137,519...41,177,626
Ensembl chr20:41,136,960...41,196,801
JBrowse link
G PPP4R1 protein phosphatase 4 regulatory subunit 1 increases expression EXP Benzophenoneidum results in increased expression of PPP4R1 protein CTD PMID:28722353 NCBI chr18:9,546,794...9,615,273
Ensembl chr18:9,546,791...9,615,240
JBrowse link
G PRIM2 DNA primase subunit 2 increases expression EXP Benzophenoneidum results in increased expression of PRIM2 protein CTD PMID:28722353 NCBI chr 6:57,314,805...57,646,852
Ensembl chr 6:57,314,805...57,646,850
JBrowse link
G PROM1 prominin 1 increases expression EXP Benzophenoneidum results in increased expression of PROM1 protein CTD PMID:28722353 NCBI chr 4:15,968,226...16,084,059
Ensembl chr 4:15,963,076...16,084,378
JBrowse link
G PRORP protein only RNase P catalytic subunit increases expression EXP Benzophenoneidum results in increased expression of PRORP protein CTD PMID:28722353 NCBI chr14:35,122,303...35,277,622
Ensembl chr14:35,122,549...35,317,474
Ensembl chr14:35,122,549...35,317,474
JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 increases expression EXP Benzophenoneidum results in increased expression of SHMT1 protein CTD PMID:28722353 NCBI chr17:18,327,873...18,363,560
Ensembl chr17:18,327,860...18,363,563
JBrowse link
G SRSF11 serine and arginine rich splicing factor 11 increases expression EXP Benzophenoneidum results in increased expression of SRSF11 protein CTD PMID:28722353 NCBI chr 1:70,205,696...70,253,052
Ensembl chr 1:70,205,682...70,253,052
JBrowse link
G TBC1D15 TBC1 domain family member 15 increases expression EXP Benzophenoneidum results in increased expression of TBC1D15 protein CTD PMID:28722353 NCBI chr12:71,839,759...71,924,313
Ensembl chr12:71,839,707...71,927,248
JBrowse link
G TFAM transcription factor A, mitochondrial increases expression EXP Benzophenoneidum results in increased expression of TFAM protein CTD PMID:28722353 NCBI chr10:58,385,409...58,399,220
Ensembl chr10:58,385,345...58,399,220
JBrowse link
G USP24 ubiquitin specific peptidase 24 increases expression EXP Benzophenoneidum results in increased expression of USP24 protein CTD PMID:28722353 NCBI chr 1:55,066,359...55,215,374
Ensembl chr 1:55,066,359...55,215,364
JBrowse link
G WASHC5 WASH complex subunit 5 increases expression EXP Benzophenoneidum results in increased expression of WASHC5 protein CTD PMID:28722353 NCBI chr 8:125,024,260...125,091,796
Ensembl chr 8:125,024,260...125,091,819
JBrowse link
aurintricarboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LIG1 DNA ligase 1 decreases activity EXP Aurintricarboxylic Acid results in decreased activity of LIG1 protein CTD PMID:15134906 NCBI chr19:48,115,445...48,170,595
Ensembl chr19:48,115,445...48,170,603
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase decreases activity EXP Aurintricarboxylic Acid results in decreased activity of OGG1 protein CTD PMID:26218629 NCBI chr 3:9,749,952...9,788,246
Ensembl chr 3:9,749,944...9,788,219
JBrowse link
azure B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein multiple interactions EXP [Azure B affects the cleavage of APP protein] which results in decreased secretion of APP protein modified form; Azure B results in decreased expression of and affects the cleavage of APP protein CTD PMID:30500345 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G BACE1 beta-secretase 1 decreases activity EXP Azure B results in decreased activity of BACE1 protein CTD PMID:30500345 NCBI chr11:117,285,207...117,316,256
Ensembl chr11:117,285,207...117,316,259
JBrowse link
Bandrowski's base term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1B1 aldo-keto reductase family 1 member B increases expression EXP Bandrowski's base results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284
JBrowse link
G AKR1B10 aldo-keto reductase family 1 member B10 increases expression EXP Bandrowski's base results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412
JBrowse link
G AKR1C1 aldo-keto reductase family 1 member C1 increases expression EXP Bandrowski's base results in increased expression of AKR1C1 mRNA CTD PMID:20566472 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 increases expression EXP Bandrowski's base results in increased expression of AKR1C3 mRNA CTD PMID:20566472 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
JBrowse link
G CAT catalase increases expression EXP Bandrowski's base results in increased expression of CAT mRNA CTD PMID:20566472 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL17 C-C motif chemokine ligand 17 affects expression EXP Bandrowski's base affects the expression of CCL17 mRNA CTD PMID:18202158 NCBI chr16:57,396,076...57,416,063
Ensembl chr16:57,404,767...57,416,063
JBrowse link
G CCL22 C-C motif chemokine ligand 22 affects expression EXP Bandrowski's base affects the expression of CCL22 mRNA CTD PMID:18202158 NCBI chr16:57,358,783...57,366,189
Ensembl chr16:57,358,783...57,366,189
JBrowse link
G CCL4 C-C motif chemokine ligand 4 affects expression EXP Bandrowski's base affects the expression of CCL4 mRNA CTD PMID:18202158 NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621
JBrowse link
G CCR7 C-C motif chemokine receptor 7 affects expression
increases expression
EXP Bandrowski's base affects the expression of CCR7 mRNA
Bandrowski's base results in increased expression of CCR7 protein
CTD PMID:18202158, PMID:19665512 NCBI chr17:40,553,769...40,565,472
Ensembl chr17:40,553,769...40,565,472
JBrowse link
G CD80 CD80 molecule increases expression EXP Bandrowski's base results in increased expression of CD80 protein CTD PMID:31958493 NCBI chr 3:119,524,293...119,559,614
Ensembl chr 3:119,524,293...119,559,614
JBrowse link
G CD86 CD86 molecule affects expression
increases expression
EXP Bandrowski's base affects the expression of CD86 mRNA
Bandrowski's base results in increased expression of CD86 protein
CTD PMID:18202158, PMID:19665512, PMID:21742781, PMID:31958493 NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 affects expression EXP Bandrowski's base affects the expression of CXCL8 mRNA CTD PMID:18202158 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 affects expression EXP Bandrowski's base affects the expression of CXCR4 mRNA CTD PMID:18202158 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
JBrowse link
G FECH ferrochelatase increases expression EXP Bandrowski's base results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:57,544,377...57,586,708
Ensembl chr18:57,544,389...57,586,702
Ensembl chr18:57,544,389...57,586,702
JBrowse link
G FTL ferritin light chain increases expression EXP Bandrowski's base results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr19:48,963,941...48,966,879
Ensembl chr19:48,965,309...48,966,879
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase increases expression EXP Bandrowski's base results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression EXP Bandrowski's base results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression EXP Bandrowski's base results in increased expression of GCLM mRNA CTD PMID:20566472 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GPX3 glutathione peroxidase 3 increases expression EXP Bandrowski's base results in increased expression of GPX3 mRNA CTD PMID:20566472 NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,438...151,028,992
JBrowse link
G GSR glutathione-disulfide reductase increases expression EXP Bandrowski's base results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G HMOX1 heme oxygenase 1 increases expression EXP Bandrowski's base results in increased expression of HMOX1 mRNA CTD PMID:20566472 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G ICAM1 intercellular adhesion molecule 1 increases expression
affects expression
EXP Bandrowski's base results in increased expression of ICAM1 protein
Bandrowski's base affects the expression of ICAM1 mRNA
CTD PMID:18202158, PMID:21742781 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G MAFF MAF bZIP transcription factor F increases expression EXP Bandrowski's base results in increased expression of MAFF mRNA CTD PMID:20566472 NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,507
JBrowse link
G MAFG MAF bZIP transcription factor G increases expression EXP Bandrowski's base results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr17:81,918,270...81,927,735
Ensembl chr17:81,918,270...81,927,735
JBrowse link
G MAFK MAF bZIP transcription factor K increases expression EXP Bandrowski's base results in increased expression of MAFK mRNA CTD PMID:20566472 NCBI chr 7:1,530,702...1,543,043
Ensembl chr 7:1,530,702...1,543,043
JBrowse link
G ME1 malic enzyme 1 increases expression EXP Bandrowski's base results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 6:83,210,402...83,431,078
Ensembl chr 6:83,210,402...83,431,051
JBrowse link
G MGST1 microsomal glutathione S-transferase 1 increases expression EXP Bandrowski's base results in increased expression of MGST1 mRNA CTD PMID:20566472 NCBI chr12:16,347,115...16,377,192
Ensembl chr12:16,347,142...16,609,259
JBrowse link
G MT1X metallothionein 1X increases expression EXP Bandrowski's base results in increased expression of MT1X mRNA CTD PMID:20566472 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression EXP Bandrowski's base results in increased expression of NQO1 mRNA CTD PMID:20566472 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G PGD phosphogluconate dehydrogenase increases expression EXP Bandrowski's base results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511
JBrowse link
G PPIA peptidylprolyl isomerase A affects expression EXP Bandrowski's base affects the expression of PPIA mRNA CTD PMID:18202158 NCBI chr 7:44,795,960...44,803,117
Ensembl chr 7:44,796,680...44,824,564
JBrowse link
G PRKCB protein kinase C beta increases expression EXP Bandrowski's base results in increased expression of PRKCB protein CTD PMID:31958493 NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611
JBrowse link
G PTGR1 prostaglandin reductase 1 increases expression EXP Bandrowski's base results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 9:111,549,722...111,599,855
Ensembl chr 9:111,549,722...111,599,893
JBrowse link
G SOD1 superoxide dismutase 1 increases expression EXP Bandrowski's base results in increased expression of SOD1 mRNA CTD PMID:20566472 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP Bandrowski's base results in increased expression of SOD2 mRNA CTD PMID:20566472 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SOD3 superoxide dismutase 3 increases expression EXP Bandrowski's base results in increased expression of SOD3 mRNA CTD PMID:20566472 NCBI chr 4:24,795,478...24,800,845
Ensembl chr 4:24,789,912...24,800,842
JBrowse link
G SRXN1 sulfiredoxin 1 increases expression EXP Bandrowski's base results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,370
Ensembl chr20:646,615...653,370
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A affects expression EXP Bandrowski's base affects the expression of TNFRSF1A mRNA CTD PMID:18202158 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114
JBrowse link
G TXN2 thioredoxin 2 increases expression EXP Bandrowski's base results in increased expression of TXN2 mRNA CTD PMID:20566472 NCBI chr22:36,467,036...36,481,672
Ensembl chr22:36,467,046...36,481,640
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression EXP Bandrowski's base results in increased expression of TXNRD1 mRNA CTD PMID:20566472 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G TXNRD2 thioredoxin reductase 2 increases expression EXP Bandrowski's base results in increased expression of TXNRD2 mRNA CTD PMID:20566472 NCBI chr22:19,875,522...19,941,818
Ensembl chr22:19,875,517...19,941,820
JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 increases expression EXP Bandrowski's base results in increased expression of UGT1A6 mRNA CTD PMID:20566472 NCBI chr 2:233,691,670...233,773,300
Ensembl chr 2:233,691,607...233,773,300
JBrowse link
brazilein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCND1 cyclin D1 decreases expression EXP brazilein results in decreased expression of CCND1 mRNA; brazilein results in decreased expression of CCND1 protein CTD PMID:23948132 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CTNNB1 catenin beta 1 decreases expression EXP brazilein results in decreased expression of CTNNB1 protein CTD PMID:23948132 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G GSK3B glycogen synthase kinase 3 beta decreases expression EXP brazilein results in decreased expression of GSK3B protein modified form CTD PMID:23948132 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions
decreases expression
EXP brazilein promotes the reaction [SB 203580 results in decreased expression of and results in decreased activity of MMP2 protein]; brazilein promotes the reaction [Wortmannin results in decreased expression of and results in decreased activity of MMP2 protein]; brazilein results in decreased expression of and results in decreased activity of MMP2 protein; SB 203580 promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]; Wortmannin promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]
brazilein results in decreased expression of MMP2 mRNA
CTD PMID:23707804 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP brazilein results in decreased expression of and results in decreased phosphorylation of NFKBIA protein CTD PMID:23707804 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit decreases expression EXP brazilein results in decreased expression of RELA protein CTD PMID:23707804 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
brazilin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator increases expression EXP brazilin results in increased expression of BAX protein CTD PMID:28063998 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP brazilin results in decreased expression of BCL2 protein CTD PMID:28063998 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BECN1 beclin 1 multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [brazilin results in increased expression of BECN1 protein]; BECN1 inhibits the reaction [brazilin results in increased activity of CASP3 protein]; BECN1 inhibits the reaction [brazilin results in increased expression of PARP1 protein modified form]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 mRNA]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 protein]
brazilin results in increased expression of BECN1 mRNA; brazilin results in increased expression of BECN1 protein
CTD PMID:28063998 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350
JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
EXP Acetylcysteine promotes the reaction [brazilin results in increased activity of CASP3 protein]; bafilomycin A1 promotes the reaction [brazilin results in increased activity of CASP3 protein]; BECN1 inhibits the reaction [brazilin results in increased activity of CASP3 protein] CTD PMID:28063998 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases expression
EXP bafilomycin A1 promotes the reaction [brazilin results in increased expression of PARP1 protein modified form]; BECN1 inhibits the reaction [brazilin results in increased expression of PARP1 protein modified form] CTD PMID:28063998 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP RELA protein promotes the reaction [brazilin results in decreased expression of SQSTM1 protein]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 mRNA]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 protein] CTD PMID:28063998 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G SQSTM1 sequestosome 1 decreases expression
multiple interactions
EXP brazilin results in decreased expression of SQSTM1 protein
Acetylcysteine inhibits the reaction [brazilin results in decreased expression of SQSTM1 protein]; RELA protein promotes the reaction [brazilin results in decreased expression of SQSTM1 protein]
CTD PMID:28063998 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
JBrowse link
brilliant green term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP brilliant green inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
bromocresol purple term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions EXP Bromcresol Purple binds to and results in decreased activity of NR1I2 protein CTD PMID:20869355 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
bromosulfophthalein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 affects transport ISO ABCB4 protein affects the transport of Sulfobromophthalein CTD PMID:15304119 NCBI chr 7:87,398,988...87,476,722
Ensembl chr 7:87,401,697...87,480,435
Ensembl chr 7:87,401,697...87,480,435
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 affects export EXP ABCC2 protein affects the export of Sulfobromophthalein CTD PMID:16046661 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G CCK cholecystokinin multiple interactions EXP Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of CCK protein modified form] CTD PMID:25106415 NCBI chr 3:42,257,826...42,266,185
Ensembl chr 3:42,257,825...42,266,185
JBrowse link
G GSTA1 glutathione S-transferase alpha 1 multiple interactions
affects binding
EXP
ISO
Sulfobromophthalein binds to and affects the folding of and affects the activity of GSTA1 protein
Sulfobromophthalein binds to [GSTA1 protein co-treated with GSTA1 protein]; Sulfobromophthalein binds to [GSTA3 protein co-treated with GSTA1 protein]
Sulfobromophthalein binds to GSTA1 protein
CTD PMID:3783048, PMID:9826190, PMID:15147239 NCBI chr 6:52,791,371...52,803,827
Ensembl chr 6:52,791,371...52,803,860
JBrowse link
G GSTM2 glutathione S-transferase mu 2 decreases activity ISO Sulfobromophthalein results in decreased activity of GSTM2 protein CTD PMID:8968379 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551
JBrowse link
G HGF hepatocyte growth factor multiple interactions ISO Sulfobromophthalein inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:18031729 NCBI chr 7:81,699,006...81,770,438
Ensembl chr 7:81,699,010...81,770,438
JBrowse link
G IFNG interferon gamma multiple interactions ISO Sulfobromophthalein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL12B interleukin 12B multiple interactions ISO Sulfobromophthalein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
JBrowse link
G KEAP1 kelch like ECH associated protein 1 decreases glutathionylation
decreases transport
ISO KEAP1 protein results in decreased glutathionylation of Sulfobromophthalein
KEAP1 protein results in decreased transport of Sulfobromophthalein
CTD PMID:19246623 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 affects abundance
increases transport
increases glutathionylation
ISO NFE2L2 protein affects the abundance of Sulfobromophthalein
NFE2L2 protein results in increased transport of Sulfobromophthalein
NFE2L2 protein results in increased glutathionylation of Sulfobromophthalein
CTD PMID:19246623 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G SLC10A1 solute carrier family 10 member 1 multiple interactions EXP Sulfobromophthalein inhibits the reaction [SLC10A1 protein results in increased uptake of Taurocholic Acid] CTD PMID:25106415 NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241
JBrowse link
G SLC16A2 solute carrier family 16 member 2 multiple interactions EXP Sulfobromophthalein inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine] CTD PMID:28119167 NCBI chr  X:74,421,493...74,533,916
Ensembl chr  X:74,421,493...74,533,917
JBrowse link
G SLC19A1 solute carrier family 19 member 1 multiple interactions
decreases activity
ISO Sulfobromophthalein inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]
Sulfobromophthalein results in decreased activity of SLC19A1 protein
CTD PMID:14612385 NCBI chr21:45,502,517...45,563,140
Ensembl chr21:45,493,572...45,573,365
JBrowse link
G SLC22A11 solute carrier family 22 member 11 multiple interactions EXP Sulfobromophthalein inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLC22A11 protein results in increased import of perfluorooctanoic acid] CTD PMID:10660625, PMID:20639259 NCBI chr11:64,555,847...64,572,875
Ensembl chr11:64,555,690...64,572,875
JBrowse link
G SLC22A6 solute carrier family 22 member 6 multiple interactions EXP Sulfobromophthalein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:11602689 NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967
Ensembl chr11:62,936,385...62,984,967
JBrowse link
G SLC22A7 solute carrier family 22 member 7 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates] CTD PMID:12065749 NCBI chr 6:43,295,710...43,305,538
Ensembl chr 6:43,295,694...43,305,538
JBrowse link
G SLC22A8 solute carrier family 22 member 8 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate] CTD PMID:10224140 NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841
JBrowse link
G SLC46A1 solute carrier family 46 member 1 multiple interactions
decreases activity
EXP
ISO
Sulfobromophthalein inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]
Sulfobromophthalein results in decreased activity of SLC46A1 protein
CTD PMID:17475902, PMID:18174275 NCBI chr17:28,394,642...28,406,630
Ensembl chr17:28,394,642...28,407,197
JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 affects import
decreases activity
multiple interactions
increases import
increases uptake
increases response to substance
EXP SLCO1B1 protein affects the import of Sulfobromophthalein
Sulfobromophthalein results in decreased activity of SLCO1B1 protein
Apigenin inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]; Budesonide inhibits the reaction [SLCO1B1 protein results in increased uptake of Sulfobromophthalein]; Clarithromycin inhibits the reaction [SLCO1B1 protein results in increased uptake of Sulfobromophthalein]; Cyclosporine inhibits the reaction [SLCO1B1 protein results in increased uptake of Sulfobromophthalein]; glimepiride affects the reaction [SLCO1B1 protein results in increased uptake of Sulfobromophthalein]; Hematoporphyrins inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]; kaempferol inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]; naringenin inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]; naringin inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]; phytochlorin inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]; Pravastatin inhibits the reaction [SLCO1B1 protein results in increased uptake of Sulfobromophthalein]; Quercetin inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]; Rifampin inhibits the reaction [SLCO1B1 protein results in increased uptake of Sulfobromophthalein]; Rutin inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]; Sulfobromophthalein inhibits the reaction [SLCO1B1 protein results in increased import of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLCO1B1 protein results in increased susceptibility to cyanoginosin LR]; Sulfobromophthalein inhibits the reaction [SLCO1B1 protein results in increased susceptibility to Okadaic Acid]; Sulfobromophthalein inhibits the reaction [SLCO1B1 protein results in increased uptake of (5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid]; Sulfobromophthalein inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin]; Sulfobromophthalein inhibits the reaction [SLCO1B1 protein results in increased uptake of estrone sulfate]
SLCO1B1 protein results in increased susceptibility to Sulfobromophthalein
CTD PMID:16046661, PMID:19560444, PMID:20171238, PMID:21430235, PMID:21661758, PMID:22394605, PMID:23121773, PMID:25106415, PMID:26134461, PMID:27450509, PMID:27989701, PMID:31364238 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796
JBrowse link
G SLCO1B3 solute carrier organic anion transporter family member 1B3 affects import
increases import
increases uptake
increases response to substance
multiple interactions
EXP SLCO1B3 protein affects the import of Sulfobromophthalein
SLCO1B3 protein results in increased import of Sulfobromophthalein
SLCO1B3 protein results in increased uptake of Sulfobromophthalein
SLCO1B3 protein results in increased susceptibility to Sulfobromophthalein
Apigenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Budesonide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Clarithromycin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Cyclosporine inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; glimepiride affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; kaempferol inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; naringenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; naringin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Nateglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Pioglitazone affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Pravastatin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Quercetin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Rutin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased import of cyanoginosin LR]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of (5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of CCK protein modified form]
CTD PMID:16046661, PMID:17369605, PMID:20171238, PMID:21430235, PMID:21661758, PMID:22394605, PMID:23121773, PMID:25106415, PMID:26134461 NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911
JBrowse link
G SLCO2B1 solute carrier organic anion transporter family member 2B1 affects import
decreases activity
multiple interactions
increases uptake
EXP SLCO2B1 protein affects the import of Sulfobromophthalein
Sulfobromophthalein results in decreased activity of SLCO2B1 protein
Budesonide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Cyclosporine inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; glimepiride inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Nateglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Pioglitazone affects the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Pravastatin inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Rifampin inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased import of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]
CTD PMID:16046661, PMID:21430235, PMID:23121773, PMID:25106415, PMID:27450509, PMID:31364238 NCBI chr11:75,151,107...75,206,549
Ensembl chr11:75,100,563...75,206,549
JBrowse link
bromothymol blue term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions EXP Bromthymol Blue binds to and results in increased activity of NR1I2 protein CTD PMID:20869355 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 multiple interactions EXP Bromthymol Blue binds to and results in decreased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr 1:161,229,666...161,238,623
Ensembl chr 1:161,229,666...161,238,302
Ensembl chr 1:161,229,666...161,238,302
JBrowse link
C3-thiacarbocyanine cation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity EXP Dithiazanine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 7:150,944,956...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
calcein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
increases secretion
increases export
EXP
ISO
[carvedilol results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; [Verapamil results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; Beclomethasone inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; desisobutyrylciclesonide inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Miconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Mometasone Furoate inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Troleandomycin inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of fluorexon]
Amiodarone inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Clotrimazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Cyclosporine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Miconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Reserpine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Troleandomycin inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]
CTD PMID:10571255, PMID:12235267, PMID:16442095 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 affects export
increases export
increases import
affects transport
multiple interactions
EXP
ISO
ABCC1 protein affects the export of fluorexon
ABCC1 protein results in increased export of fluorexon
ABCC1 protein results in increased import of fluorexon
ABCC1 protein affects the transport of fluorexon
Mefloquine inhibits the reaction [ABCC1 protein affects the export of fluorexon]; nobiletin promotes the reaction [ABCC1 protein results in increased import of fluorexon]; Quercetin inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; robinetin inhibits the reaction [ABCC1 protein affects the export of fluorexon]; Silymarin inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein affects the export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; Vincristine inhibits the reaction [ABCC1 protein affects the transport of fluorexon]
CTD PMID:10685512, PMID:15670588, PMID:16004972, PMID:16156793, PMID:18955043, PMID:26454883 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 affects export
increases abundance
multiple interactions
affects transport
EXP ABCC2 protein affects the export of fluorexon
ABCC2 protein alternative form results in increased abundance of fluorexon
robinetin inhibits the reaction [ABCC2 protein affects the export of fluorexon]
ABCC2 protein affects the transport of fluorexon
CTD PMID:15670588, PMID:15848949, PMID:22027652 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC6 ATP binding cassette subfamily C member 6 affects transport EXP ABCC6 affects the transport of fluorexon CTD PMID:14667841 NCBI chr16:16,149,565...16,223,617
Ensembl chr16:16,148,928...16,223,522
JBrowse link
calcein am term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
increases export
increases activity
affects export
increases secretion
increases transport
EXP
ISO
2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [Endosulfan co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [phosalone co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [Verapamil binds to and results in decreased activity of ABCB1 protein] inhibits the reaction [sodium arsenite promotes the reaction [ABCB1 protein results in increased secretion of calcein AM]]; ABCB1 protein affects the reaction [Mifepristone results in decreased transport of calcein AM]; ABCB1 protein affects the reaction [zosuquidar trihydrochloride results in decreased transport of calcein AM]; Atorvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; chlorpyrifos-methyl affects the reaction [ABCB1 protein results in increased transport of calcein AM]; Cyclosporine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; deoxynivalenol inhibits the reaction [valspodar inhibits the reaction [ABCB1 protein results in increased export of calcein AM]]; Diazinon inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Diazinon promotes the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Endosulfan inhibits the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Endosulfan promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; fenoxycarb inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; fenvalerate inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; phosalone inhibits the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; phosalone inhibits the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; propiconazole inhibits the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole promotes the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Reserpine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; Simvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; sodium arsenite promotes the reaction [ABCB1 protein results in increased secretion of calcein AM]; valspodar inhibits the reaction [ABCB1 protein results in increased export of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Verapamil promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]
ABCB1A protein promotes the reaction [Emodin results in increased export of calcein AM]
calcein AM results in increased activity of ABCB1 protein mutant form
CTD PMID:10617675, PMID:12711602, PMID:15616150, PMID:16121039, PMID:19223659, PMID:19549930, PMID:21783720, PMID:29174985, PMID:30217652 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCB11 ATP binding cassette subfamily B member 11 affects export
multiple interactions
ISO ABCB11 protein affects the export of calcein AM
ditekiren inhibits the reaction [ABCB11 protein affects the export of calcein AM]
CTD PMID:10617675 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 increases transport
multiple interactions
EXP ABCC1 protein results in increased transport of calcein AM
[ABCC1 protein results in increased susceptibility to Silver Nitrate] which results in decreased export of calcein AM; [ABCC1 protein results in increased susceptibility to Silver] which results in decreased export of calcein AM; [MYC protein results in increased expression of ABCC1 protein] which results in increased export of calcein AM; verlukast inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]; zearalenol metabolite inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]
CTD PMID:19239227, PMID:19647055, PMID:27376922 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 affects transport
multiple interactions
increases transport
increases export
EXP
ISO
ABCC2 protein affects the transport of calcein AM
Atorvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Simvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]
[MYC protein results in increased expression of ABCC2 protein] which results in increased export of calcein AM; Atorvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; montelukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; Simvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; zearalenol inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]
CTD PMID:15210835, PMID:15616150, PMID:19239227, PMID:19647055, PMID:19952419 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 affects transport
multiple interactions
increases transport
EXP ABCC3 protein affects the transport of calcein AM
Dexamethasone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Glutathione promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Hydrocortisone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Prednisone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; verlukast inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]; zearalenol inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]
CTD PMID:15210835, PMID:15979871, PMID:19647055 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253
JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 multiple interactions EXP Glutathione promotes the reaction [ABCC4 protein affects the transport of calcein AM] CTD PMID:15210835 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
JBrowse link
G ABCC6 ATP binding cassette subfamily C member 6 multiple interactions EXP Glutathione promotes the reaction [ABCC6 protein affects the transport of calcein AM] CTD PMID:15210835 NCBI chr16:16,149,565...16,223,617
Ensembl chr16:16,148,928...16,223,522
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions EXP [MYC protein results in increased expression of ABCC1 protein] which results in increased export of calcein AM; [MYC protein results in increased expression of ABCC2 protein] which results in increased export of calcein AM CTD PMID:19239227 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
cascade blue term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO2B1 solute carrier organic anion transporter family member 2B1 increases uptake
multiple interactions
EXP SLCO2B1 protein results in increased uptake of Cascade Blue
Bleomycin inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Capecitabine inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Docetaxel inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Etoposide inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Irinotecan inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Methotrexate inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Tamoxifen inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Teniposide inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Thiotepa inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]
CTD PMID:30863990 NCBI chr11:75,151,107...75,206,549
Ensembl chr11:75,100,563...75,206,549
JBrowse link
clofazimine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 decreases activity EXP Clofazimine results in decreased activity of ABCB11 protein CTD PMID:20829430, PMID:23956101 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ACACA acetyl-CoA carboxylase alpha increases expression ISO Clofazimine results in increased expression of ACACA mRNA CTD PMID:31393584 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha increases expression ISO Clofazimine results in increased expression of CEBPA protein CTD PMID:31393584 NCBI chr19:33,299,934...33,302,564
Ensembl chr19:33,299,934...33,302,534
JBrowse link
G DGAT1 diacylglycerol O-acyltransferase 1 decreases expression ISO Clofazimine results in decreased expression of DGAT1 mRNA CTD PMID:31393584 NCBI chr 8:144,314,584...144,326,852
Ensembl chr 8:144,314,584...144,326,910
JBrowse link
G FAS Fas cell surface death receptor increases expression ISO Clofazimine results in increased expression of FAS mRNA CTD PMID:31393584 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions EXP Clofazimine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity EXP Clofazimine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 7:150,944,956...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma increases expression ISO Clofazimine results in increased expression of PPARG mRNA; Clofazimine results in increased expression of PPARG protein CTD PMID:31393584 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 increases expression ISO Clofazimine results in increased expression of SREBF1 mRNA CTD PMID:31393584 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,011
JBrowse link
G ZNF423 zinc finger protein 423 increases expression ISO Clofazimine results in increased expression of ZFP423 mRNA CTD PMID:31393584 NCBI chr16:49,487,524...49,857,919
Ensembl chr16:49,487,524...49,857,919
JBrowse link
coumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AASS aminoadipate-semialdehyde synthase decreases expression ISO coumarin results in decreased expression of AASS mRNA CTD PMID:18480146 NCBI chr 7:122,073,544...122,144,269
Ensembl chr 7:122,073,549...122,144,255
JBrowse link
G ABCB11 ATP binding cassette subfamily B member 11 affects expression ISO coumarin affects the expression of ABCB11 mRNA CTD PMID:16963487 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 increases expression ISO coumarin results in increased expression of ABCC3 mRNA CTD PMID:18480146 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253
JBrowse link
G ACAA1 acetyl-CoA acyltransferase 1 increases expression ISO coumarin results in increased expression of ACAA1 mRNA CTD PMID:18480146 NCBI chr 3:38,122,710...38,137,127
Ensembl chr 3:38,103,129...38,137,242
JBrowse link
G ACAA2 acetyl-CoA acyltransferase 2 affects expression ISO coumarin affects the expression of ACAA2 mRNA CTD PMID:16963487 NCBI chr18:49,782,164...49,813,533
Ensembl chr18:49,782,164...49,813,953
JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions ISO coumarin inhibits the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; coumarin inhibits the reaction [haloxon results in increased phosphorylation of ACHE protein]; coumarin inhibits the reaction [Paraoxon results in increased phosphorylation of ACHE protein] CTD PMID:10421444 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ACLY ATP citrate lyase affects expression ISO coumarin affects the expression of ACLY mRNA CTD PMID:16963487 NCBI chr17:41,866,916...41,930,542
Ensembl chr17:41,866,917...41,930,542
JBrowse link
G ACO1 aconitase 1 affects expression ISO coumarin affects the expression of ACO1 mRNA CTD PMID:16963487 NCBI chr 9:32,384,643...32,454,769
Ensembl chr 9:32,384,603...32,454,769
JBrowse link
G ACOT4 acyl-CoA thioesterase 4 increases expression ISO coumarin results in increased expression of ACOT4 mRNA CTD PMID:18480146 NCBI chr14:73,591,873...73,595,766
Ensembl chr14:73,591,706...73,596,496
JBrowse link
G ACSM1 acyl-CoA synthetase medium chain family member 1 increases expression ISO coumarin results in increased expression of ACSM1 mRNA CTD PMID:17311802 NCBI chr16:20,623,235...20,697,788
Ensembl chr16:20,623,237...20,698,890
JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 decreases expression EXP coumarin analog results in decreased expression of AIFM1 mRNA CTD PMID:32578917 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G AKR1C4 aldo-keto reductase family 1 member C4 decreases expression ISO coumarin results in decreased expression of AKR1C6 mRNA CTD PMID:18480146 NCBI chr10:5,196,837...5,218,949
Ensembl chr10:5,195,462...5,218,949
JBrowse link
G AKR1D1 aldo-keto reductase family 1 member D1 affects expression ISO coumarin affects the expression of AKR1D1 mRNA CTD PMID:16963487 NCBI chr 7:138,076,459...138,118,305
Ensembl chr 7:138,002,324...138,118,305
JBrowse link
G AKR7A3 aldo-keto reductase family 7 member A3 increases expression ISO coumarin results in increased expression of AKR7A3 mRNA CTD PMID:18480146 NCBI chr 1:19,274,229...19,289,362
Ensembl chr 1:19,282,573...19,288,770
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP coumarin analog results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:32578917 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 increases expression ISO coumarin results in increased expression of ALDH1A1 mRNA CTD PMID:18480146 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442
JBrowse link
G ALOX5 arachidonate 5-lipoxygenase increases expression ISO coumarin results in increased expression of ALOX5 mRNA CTD PMID:18480146 NCBI chr10:45,374,209...45,446,121
Ensembl chr10:45,374,176...45,446,119
JBrowse link
G ANXA7 annexin A7 increases expression ISO coumarin results in increased expression of ANXA7 mRNA CTD PMID:18480146 NCBI chr10:73,375,101...73,414,058
Ensembl chr10:73,375,101...73,414,076
JBrowse link
G APBB3 amyloid beta precursor protein binding family B member 3 decreases expression ISO coumarin results in decreased expression of APBB3 mRNA CTD PMID:18480146 NCBI chr 5:140,558,268...140,564,598
Ensembl chr 5:140,558,268...140,564,781
JBrowse link
G APCS amyloid P component, serum decreases expression ISO coumarin results in decreased expression of APCS mRNA CTD PMID:18480146 NCBI chr 1:159,587,826...159,588,865
Ensembl chr 1:159,587,826...159,588,865
JBrowse link
G ARG1 arginase 1 affects expression ISO coumarin affects the expression of ARG1 mRNA CTD PMID:16963487 NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332
JBrowse link
G ASNS asparagine synthetase (glutamine-hydrolyzing) increases expression ISO coumarin results in increased expression of ASNS mRNA CTD PMID:18480146 NCBI chr 7:97,851,677...97,928,441
Ensembl chr 7:97,851,677...97,872,542
JBrowse link
G ATP5IF1 ATP synthase inhibitory factor subunit 1 increases expression ISO coumarin results in increased expression of ATPIF1 mRNA CTD PMID:18480146 NCBI chr 1:28,236,124...28,238,100
Ensembl chr 1:28,236,109...28,246,906
JBrowse link
G ATRN attractin decreases expression ISO coumarin results in decreased expression of ATRN mRNA CTD PMID:18480146 NCBI chr20:3,471,018...3,651,118
Ensembl chr20:3,471,018...3,651,118
JBrowse link
G AVPR1A arginine vasopressin receptor 1A decreases expression ISO coumarin results in decreased expression of AVPR1A mRNA CTD PMID:18480146 NCBI chr12:63,142,759...63,151,201
Ensembl chr12:63,142,759...63,150,942
Ensembl chr12:63,142,759...63,150,942
JBrowse link
G AZGP1 alpha-2-glycoprotein 1, zinc-binding affects expression ISO coumarin affects the expression of AZGP1 mRNA CTD PMID:16963487 NCBI chr 7:99,966,730...99,976,031
Ensembl chr 7:99,966,720...99,976,042
JBrowse link
G BAD BCL2 associated agonist of cell death increases expression EXP coumarin analog results in increased expression of BAD mRNA CTD PMID:32578917 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704
JBrowse link
G BAK1 BCL2 antagonist/killer 1 increases expression EXP coumarin analog results in increased expression of BAK1 protein CTD PMID:31199928 NCBI chr 6:33,572,552...33,580,296
Ensembl chr 6:33,572,547...33,580,293
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP coumarin analog results in increased expression of BAX mRNA; coumarin results in increased expression of BAX protein CTD PMID:15964220, PMID:32578917 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BBC3 BCL2 binding component 3 increases expression EXP coumarin analog results in increased expression of BBC3 protein CTD PMID:31199928 NCBI chr19:47,220,822...47,232,998
Ensembl chr19:47,220,822...47,232,766
JBrowse link
G BBOX1 gamma-butyrobetaine hydroxylase 1 decreases expression ISO coumarin results in decreased expression of BBOX1 mRNA CTD PMID:18480146 NCBI chr11:27,040,705...27,127,809
Ensembl chr11:27,040,725...27,127,809
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP coumarin analog results in decreased expression of BCL2 mRNA; coumarin results in decreased expression of BCL2 protein CTD PMID:15964220, PMID:32578917 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BHLHA15 basic helix-loop-helix family member a15 increases expression ISO coumarin results in increased expression of BHLHA15 mRNA CTD PMID:18480146 NCBI chr 7:98,211,439...98,215,457
Ensembl chr 7:98,211,427...98,212,979
JBrowse link
G BHMT betaine--homocysteine S-methyltransferase decreases expression
affects expression
ISO coumarin results in decreased expression of BHMT mRNA
coumarin affects the expression of BHMT mRNA
CTD PMID:16963487, PMID:18480146 NCBI chr 5:79,111,809...79,132,288
Ensembl chr 5:79,111,809...79,132,288
JBrowse link
G BID BH3 interacting domain death agonist increases expression EXP coumarin analog results in increased expression of BID mRNA CTD PMID:32578917 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 decreases expression EXP coumarin analog results in decreased expression of BIRC5 mRNA CTD PMID:32578917 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G CA1 carbonic anhydrase 1 decreases activity EXP coumarin results in decreased activity of CA1 protein CTD PMID:22077347 NCBI chr 8:85,327,608...85,378,113
Ensembl chr 8:85,327,608...85,379,014
JBrowse link
G CA2 carbonic anhydrase 2 increases expression
decreases activity
ISO
EXP
coumarin results in increased expression of CA2 mRNA
coumarin results in decreased activity of CA2 protein
CTD PMID:18480146, PMID:22077347 NCBI chr 8:85,464,007...85,481,493
Ensembl chr 8:85,463,968...85,481,493
JBrowse link
G CA3 carbonic anhydrase 3 decreases expression ISO coumarin results in decreased expression of CA3 mRNA CTD PMID:18480146 NCBI chr 8:85,438,859...85,449,040
Ensembl chr 8:85,373,436...85,449,040
JBrowse link
G CAPN1 calpain 1 decreases expression EXP coumarin analog results in decreased expression of CAPN1 mRNA CTD PMID:32578917 NCBI chr11:65,181,373...65,212,006
Ensembl chr11:65,180,566...65,212,006
JBrowse link
G CASP3 caspase 3 increases expression
increases cleavage
EXP coumarin analog results in increased expression of CASP3 mRNA
coumarin analog results in increased cleavage of CASP3 protein
CTD PMID:32578917 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 increases expression EXP coumarin analog results in increased expression of CASP8 mRNA CTD PMID:32578917 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 increases expression EXP coumarin analog results in increased expression of CASP9 mRNA CTD PMID:32578917 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions
decreases activity
ISO
EXP
coumarin inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased activity of CAT protein]
coumarin analog results in decreased activity of CAT protein
CTD PMID:21630391, PMID:32578917 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CBR1 carbonyl reductase 1 increases expression ISO coumarin results in increased expression of CBR1 mRNA CTD PMID:18480146 NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166
JBrowse link
G CCNB2 cyclin B2 decreases expression ISO coumarin results in decreased expression of CCNB2 mRNA CTD PMID:18480146 NCBI chr15:59,105,146...59,125,045
Ensembl chr15:59,105,126...59,125,045
JBrowse link
G CCND1 cyclin D1 decreases expression EXP coumarin analog results in decreased expression of CCND1 mRNA CTD PMID:32578917 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCNE1 cyclin E1 increases expression
decreases expression
ISO
EXP
coumarin results in increased expression of CCNE1 mRNA
coumarin analog results in decreased expression of CCNE1 mRNA
CTD PMID:18480146, PMID:32578917 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CCNE2 cyclin E2 increases expression ISO coumarin results in increased expression of CCNE2 mRNA CTD PMID:18480146 NCBI chr 8:94,880,224...94,896,671
Ensembl chr 8:94,879,770...94,896,678
JBrowse link
G CDH1 cadherin 1 increases expression EXP coumarin analog results in increased expression of CDH1 mRNA; coumarin analog results in increased expression of CDH1 protein CTD PMID:32578917 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,541
JBrowse link
G CDH2 cadherin 2 decreases expression EXP coumarin analog results in decreased expression of CDH2 mRNA CTD PMID:32578917 NCBI chr18:27,932,878...28,177,130
Ensembl chr18:27,932,879...28,177,946
Ensembl chr18:27,932,879...28,177,946
JBrowse link
G CDK2 cyclin dependent kinase 2 decreases expression EXP coumarin analog results in decreased expression of CDK2 mRNA CTD PMID:32578917 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression EXP coumarin analog results in decreased expression of CDK4 mRNA CTD PMID:32578917 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP coumarin analog results in increased expression of CDKN1A mRNA CTD PMID:32578917 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CDKN3 cyclin dependent kinase inhibitor 3 decreases expression ISO coumarin results in decreased expression of CDKN3 mRNA CTD PMID:18480146 NCBI chr14:54,396,873...54,420,218
Ensembl chr14:54,396,849...54,420,218
JBrowse link
G CDO1 cysteine dioxygenase type 1 affects expression ISO coumarin affects the expression of CDO1 mRNA CTD PMID:16963487 NCBI chr 5:115,804,733...115,816,659
Ensembl chr 5:115,804,733...115,816,659
JBrowse link
G CES1 carboxylesterase 1 increases expression ISO coumarin results in increased expression of CES1 mRNA CTD PMID:17311802 NCBI chr16:55,802,851...55,833,127
Ensembl chr16:55,802,851...55,833,337
JBrowse link
G CISD3 CDGSH iron sulfur domain 3 increases expression ISO coumarin results in increased expression of CISD3 mRNA CTD PMID:18480146 NCBI chr17:38,730,341...38,735,605
Ensembl chr17:38,730,341...38,735,605
JBrowse link
G CLDN3 claudin 3 decreases expression EXP coumarin analog results in decreased expression of CLDN3 mRNA CTD PMID:32578917 NCBI chr 7:73,768,997...73,770,270
Ensembl chr 7:73,768,997...73,770,270
JBrowse link
G CLDN4 claudin 4 decreases expression EXP coumarin analog results in decreased expression of CLDN4 mRNA CTD PMID:32578917 NCBI chr 7:73,830,996...73,832,690
Ensembl chr 7:73,799,542...73,832,693
JBrowse link
G COQ6 coenzyme Q6, monooxygenase increases expression ISO coumarin results in increased expression of COQ6 mRNA CTD PMID:18480146 NCBI chr14:73,949,926...73,963,670
Ensembl chr14:73,949,926...73,963,670
JBrowse link
G CREG1 cellular repressor of E1A stimulated genes 1 increases expression ISO coumarin results in increased expression of CREG mRNA CTD PMID:18480146 NCBI chr 1:167,541,013...167,553,762
Ensembl chr 1:167,529,117...167,553,805
JBrowse link
G CRELD2 cysteine rich with EGF like domains 2 increases expression ISO coumarin results in increased expression of CRELD2 mRNA CTD PMID:18480146 NCBI chr22:49,918,634...49,927,540
Ensembl chr22:49,918,167...49,927,540
JBrowse link
G CRYAB crystallin alpha B decreases expression ISO coumarin results in decreased expression of CRYAB mRNA CTD PMID:18480146 NCBI chr11:111,908,564...111,923,740
Ensembl chr11:111,908,564...111,923,722
JBrowse link
G CRYL1 crystallin lambda 1 increases expression ISO coumarin results in increased expression of CRYL1 mRNA CTD PMID:18480146 NCBI chr13:20,403,669...20,525,857
Ensembl chr13:20,403,666...20,525,873
JBrowse link
G CSAD cysteine sulfinic acid decarboxylase decreases expression ISO coumarin results in decreased expression of CSAD mRNA CTD PMID:18480146 NCBI chr12:53,157,663...53,181,663
Ensembl chr12:53,157,663...53,180,909
JBrowse link
G CSRP1 cysteine and glycine rich protein 1 decreases expression ISO coumarin results in decreased expression of CSRP1 mRNA CTD PMID:18480146 NCBI chr 1:201,483,530...201,507,123
Ensembl chr 1:201,483,530...201,509,456
JBrowse link
G CTF1 cardiotrophin 1 increases expression ISO coumarin results in increased expression of CTF1 mRNA CTD PMID:18480146 NCBI chr16:30,895,824...30,903,560
Ensembl chr16:30,896,614...30,903,547
Ensembl chr16:30,896,614...30,903,547
JBrowse link
G CTH cystathionine gamma-lyase affects expression ISO coumarin affects the expression of CTH mRNA CTD PMID:16963487 NCBI chr 1:70,411,268...70,441,949
Ensembl chr 1:70,411,218...70,439,851
JBrowse link
G CTNNB1 catenin beta 1 decreases expression EXP coumarin analog results in decreased expression of CTNNB1 mRNA CTD PMID:32578917 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CTSB cathepsin B increases expression EXP coumarin analog results in increased expression of CTSB mRNA CTD PMID:32578917 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,448
JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 decreases expression ISO coumarin results in decreased expression of CXCL12 mRNA CTD PMID:18480146 NCBI chr10:44,292,088...44,385,097
Ensembl chr10:44,370,165...44,386,493
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 decreases expression EXP coumarin analog results in decreased expression of CXCL8 mRNA CTD PMID:32578917 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYB561 cytochrome b561 increases expression ISO coumarin results in increased expression of CYB561 mRNA CTD PMID:18480146 NCBI chr17:63,432,304...63,446,639
Ensembl chr17:63,432,304...63,446,354
JBrowse link
G CYCS cytochrome c, somatic increases expression EXP coumarin analog results in increased expression of CYCS mRNA CTD PMID:32578917 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases expression
affects expression
ISO coumarin results in decreased expression of CYP1A2 mRNA
coumarin affects the expression of CYP1A2 mRNA
CTD PMID:16963487, PMID:18480146 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2A13 cytochrome P450 family 2 subfamily A member 13 decreases hydroxylation
affects metabolic processing
increases hydroxylation
EXP
ISO
CYP2A13 gene polymorphism results in decreased hydroxylation of coumarin
CYP2A5 protein affects the metabolism of coumarin
CYP2A13 protein results in increased hydroxylation of coumarin
CTD PMID:10646973, PMID:17922361 NCBI chr19:41,088,451...41,096,195
Ensembl chr19:41,088,451...41,096,195
JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 decreases activity
increases hydroxylation
affects binding
multiple interactions
affects metabolic processing
increases metabolic processing
decreases metabolic processing
EXP coumarin results in decreased activity of CYP2A6 protein
CYP2A6 protein polymorphism results in increased hydroxylation of coumarin; CYP2A6 protein results in increased hydroxylation of coumarin
coumarin binds to CYP2A6 protein
[5-chlorotryptamine analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [5-methyltryptamine analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [7-methyltryptamine analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [CYP2A6 protein results in increased metabolism of coumarin] which results in increased chemical synthesis of 7-hydroxycoumarin; [indopan analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [indopan results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [Tranylcypromine results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [Tryptamines analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; coumarin inhibits the reaction [CYP2A6 protein results in increased glutathionylation of Lamotrigine]; CYP2A6 protein binds to and results in increased metabolism of coumarin; CYP2A6 protein results in increased metabolism of and affects the abundance of coumarin; Methoxsalen inhibits the reaction [CYP2A6 protein results in increased metabolism of coumarin]; nitrosobenzylmethylamine inhibits the reaction [CYP2A6 protein results in increased hydroxylation of coumarin]; perfluorooctane sulfonic acid inhibits the reaction [CYP2A6 protein results in increased hydroxylation of coumarin]; Proadifen inhibits the reaction [CYP2A6 protein results in increased metabolism of coumarin]; Tranylcypromine inhibits the reaction [CYP2A6 protein results in increased metabolism of coumarin]
CYP2A6 promoter SNP affects the metabolism of coumarin; CYP2A6 protein affects the metabolism of coumarin; CYP2A6 protein mutant form affects the metabolism of coumarin
CYP2A6 exon SNP results in increased metabolism of coumarin; CYP2A6 protein results in increased metabolism of coumarin
CYP2A6 exon SNP results in decreased metabolism of coumarin
CTD PMID:8819299, PMID:10616189, PMID:11237731, PMID:11376561, PMID:11393269, PMID:11504148, PMID:11684323, PMID:11779172, PMID:11927840, PMID:12325023, PMID:12401345, PMID:12406643, PMID:12433797, PMID:12464242, PMID:12818727, PMID:14583682, PMID:15155557, PMID:15592323, PMID:15618666, PMID:15626586, PMID:15681899, PMID:15728263, PMID:15980104, PMID:16035375, PMID:16124035, PMID:16126166, PMID:16207711, PMID:17220563, PMID:17565714, PMID:18216723, PMID:18979093, PMID:19082995, PMID:19961160, PMID:21915887, PMID:21964418, PMID:22634058, PMID:24924949, PMID:26599973, PMID:32198085 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 affects metabolic processing
affects response to substance
EXP CYP2C9 protein polymorphism affects the metabolism of coumarin
CYP2C9 protein polymorphism affects the susceptibility to coumarin
CTD PMID:17849045, PMID:23582453 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 affects localization ISO coumarin affects the localization of CYP2E1 protein CTD PMID:28803882 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 decreases expression ISO coumarin results in decreased expression of CYP51 mRNA CTD PMID:18480146 NCBI chr 7:92,112,153...92,134,803
Ensembl chr 7:92,112,153...92,134,803
JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO coumarin results in decreased expression of CYP7A1 mRNA CTD PMID:18480146 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163
JBrowse link
G DDIT4L DNA damage inducible transcript 4 like increases expression ISO coumarin results in increased expression of DDIT4L mRNA CTD PMID:18480146 NCBI chr 4:100,185,870...100,190,468
Ensembl chr 4:100,185,870...100,190,782
JBrowse link
G DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit increases expression ISO coumarin results in increased expression of DDOST mRNA CTD PMID:18480146 NCBI chr 1:20,651,777...20,661,369
Ensembl chr 1:20,651,767...20,661,544
JBrowse link
G DDX31 DEAD-box helicase 31 decreases expression ISO coumarin results in decreased expression of DDX31 mRNA CTD PMID:18480146 NCBI chr 9:132,592,997...132,670,401
Ensembl chr 9:132,592,997...132,670,401
JBrowse link
G DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 increases expression ISO coumarin results in increased expression of DNAJB11 mRNA CTD PMID:18480146 NCBI chr 3:186,570,720...186,585,793
Ensembl chr 3:186,567,403...186,585,800
JBrowse link
G DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 affects expression ISO coumarin affects the expression of DNAJB9 mRNA CTD PMID:16963487 NCBI chr 7:108,569,874...108,574,850
Ensembl chr 7:108,569,867...108,574,850
JBrowse link
G DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 increases expression ISO coumarin results in increased expression of DNAJC3 mRNA CTD PMID:18480146 NCBI chr13:95,677,139...95,794,988
Ensembl chr13:95,677,139...95,794,988
JBrowse link
G DSCC1 DNA replication and sister chromatid cohesion 1 increases expression ISO coumarin results in increased expression of DSCC1 mRNA CTD PMID:18480146 NCBI chr 8:119,833,960...119,855,920
Ensembl chr 8:119,833,976...119,855,894
JBrowse link
G ECI1 enoyl-CoA delta isomerase 1 affects expression ISO coumarin affects the expression of ECI1 mRNA CTD PMID:16963487 NCBI chr16:2,239,402...2,251,587
Ensembl chr16:2,239,402...2,252,300
JBrowse link
G EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 increases expression ISO coumarin results in increased expression of EEF1E1 mRNA CTD PMID:18480146 NCBI chr 6:8,073,360...8,102,548
Ensembl chr 6:8,073,360...8,102,559
JBrowse link
G ELL3 elongation factor for RNA polymerase II 3 increases expression ISO coumarin results in increased expression of ELL3 mRNA CTD PMID:18480146 NCBI chr15:43,772,620...43,776,966
Ensembl chr15:43,772,605...43,777,315
JBrowse link
G EME2 essential meiotic structure-specific endonuclease subunit 2 increases expression ISO coumarin results in increased expression of EME2 mRNA CTD PMID:18480146 NCBI chr16:1,773,222...1,776,714
Ensembl chr16:1,772,810...1,781,708
JBrowse link
G EPHX1 epoxide hydrolase 1 increases expression ISO coumarin results in increased expression of EPHX1 mRNA CTD PMID:17311802 NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,092...225,845,563
JBrowse link
G F9 coagulation factor IX increases response to substance EXP F9 exon polymorphism results in increased susceptibility to coumarin; F9 protein mutant form results in increased susceptibility to coumarin CTD PMID:11307814 NCBI chr  X:139,530,720...139,563,459
Ensembl chr  X:139,530,739...139,563,459
Ensembl chr  X:139,530,739...139,563,459
JBrowse link
G FADS1 fatty acid desaturase 1 decreases expression ISO coumarin results in decreased expression of FADS1 mRNA CTD PMID:18480146 NCBI chr11:61,799,627...61,817,003
Ensembl chr11:61,799,627...61,829,318
JBrowse link
G FAM111A family with sequence similarity 111 member A increases expression ISO coumarin results in increased expression of FAM111A mRNA CTD PMID:18480146 NCBI chr11:59,142,856...59,155,039
Ensembl chr11:59,142,748...59,155,039
JBrowse link
G FASN fatty acid synthase affects expression ISO coumarin affects the expression of FASN mRNA CTD PMID:16963487 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FEN1 flap structure-specific endonuclease 1 increases expression ISO coumarin results in increased expression of FEN1 mRNA CTD PMID:18480146 NCBI chr11:61,792,911...61,797,238
Ensembl chr11:61,792,911...61,797,238
JBrowse link
G FGG fibrinogen gamma chain affects expression ISO coumarin affects the expression of FGG mRNA CTD PMID:16963487 NCBI chr 4:154,604,136...154,612,656
Ensembl chr 4:154,604,134...154,612,967
JBrowse link
G FGGY FGGY carbohydrate kinase domain containing decreases expression ISO coumarin results in decreased expression of FGGY mRNA CTD PMID:18480146 NCBI chr 1:59,296,405...59,762,730
Ensembl chr 1:59,296,638...59,810,647
JBrowse link
G FKBP11 FKBP prolyl isomerase 11 increases expression ISO coumarin results in increased expression of FKBP11 mRNA CTD PMID:18480146 NCBI chr12:48,921,963...48,925,492
Ensembl chr12:48,921,518...48,926,474
JBrowse link
G FMO1 flavin containing dimethylaniline monoxygenase 1 decreases expression ISO coumarin results in decreased expression of FMO1 mRNA CTD PMID:18480146 NCBI chr 1:171,248,473...171,285,978
Ensembl chr 1:171,248,471...171,285,978
JBrowse link
G GAS5 growth arrest specific 5 increases expression ISO coumarin results in increased expression of GAS5 mRNA CTD PMID:18480146 NCBI chr 1:173,863,899...173,868,882
Ensembl chr 1:173,858,559...173,868,882
JBrowse link
G GCKR glucokinase regulator decreases expression ISO coumarin results in decreased expression of GCKR mRNA CTD PMID:18480146 NCBI chr 2:27,496,839...27,523,689
Ensembl chr 2:27,496,839...27,523,684
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression ISO coumarin results in increased expression of GCLC mRNA CTD PMID:18480146 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression ISO coumarin results in increased expression of GCLM mRNA CTD PMID:18480146 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GJB2 gap junction protein beta 2 increases expression ISO coumarin results in increased expression of GJB2 mRNA CTD PMID:18480146 NCBI chr13:20,187,470...20,192,938
Ensembl chr13:20,187,463...20,192,938
JBrowse link
G GK glycerol kinase decreases expression ISO coumarin results in decreased expression of GK mRNA CTD PMID:18480146 NCBI chr  X:30,653,348...30,731,462
Ensembl chr  X:30,653,359...30,731,456
JBrowse link
G GLB1 galactosidase beta 1 increases expression ISO coumarin results in increased expression of GLB1 mRNA CTD PMID:18480146 NCBI chr 3:32,996,617...33,097,146
Ensembl chr 3:32,996,609...33,097,202
JBrowse link
G GLDC glycine decarboxylase decreases expression ISO coumarin results in decreased expression of GLDC mRNA CTD PMID:18480146 NCBI chr 9:6,532,467...6,645,729
Ensembl chr 9:6,532,464...6,645,783
Ensembl chr 9:6,532,464...6,645,783
JBrowse link
G GPR108 G protein-coupled receptor 108 decreases expression ISO coumarin results in decreased expression of GPR108 mRNA CTD PMID:18480146 NCBI chr19:6,729,914...6,737,622
Ensembl chr19:6,729,914...6,737,603
JBrowse link
G GPX1 glutathione peroxidase 1 affects expression ISO coumarin affects the expression of GPX1 mRNA CTD PMID:16963487 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,358
JBrowse link
G GSR glutathione-disulfide reductase increases expression ISO coumarin results in increased expression of GSR mRNA CTD PMID:18480146 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSTA3 glutathione S-transferase alpha 3 increases expression ISO coumarin results in increased expression of GSTA3 protein CTD PMID:11309284 NCBI chr 6:52,896,646...52,909,799
Ensembl chr 6:52,896,639...52,909,698
JBrowse link
G GSTA4 glutathione S-transferase alpha 4 increases expression ISO coumarin results in increased expression of GSTA4 protein CTD PMID:11309284 NCBI chr 6:52,977,952...52,995,332
Ensembl chr 6:52,977,948...52,995,304
JBrowse link
G GSTA5 glutathione S-transferase alpha 5 increases expression ISO coumarin results in increased expression of GSTA5 protein
coumarin results in increased expression of GSTA1 protein
CTD PMID:9794803, PMID:11309284 NCBI chr 6:52,831,742...52,846,095
Ensembl chr 6:52,831,655...52,846,095
JBrowse link
G GSTM1 glutathione S-transferase mu 1 increases expression ISO coumarin results in increased expression of GSTM5 protein CTD PMID:11309284 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
JBrowse link
G GSTM3 glutathione S-transferase mu 3 increases expression ISO coumarin results in increased expression of GSTM3 protein CTD PMID:9794803 NCBI chr 1:109,733,937...109,741,038
Ensembl chr 1:109,733,932...109,741,038
JBrowse link
G GSTP1 glutathione S-transferase pi 1 increases expression ISO coumarin results in increased expression of GSTP1 protein CTD PMID:9794803, PMID:11309284 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G GSTT1 glutathione S-transferase theta 1 increases expression ISO coumarin results in increased expression of GSTT1 mRNA; coumarin results in increased expression of GSTT1 protein CTD PMID:9794803, PMID:9855024, PMID:10413528
G HAL histidine ammonia-lyase decreases expression ISO coumarin results in decreased expression of HAL mRNA CTD PMID:18480146 NCBI chr12:95,972,662...95,996,344
Ensembl chr12:95,972,662...95,996,365
JBrowse link
G HAO2 hydroxyacid oxidase 2 decreases expression ISO coumarin results in decreased expression of HAO2 mRNA CTD PMID:18480146 NCBI chr 1:119,361,913...119,394,130
Ensembl chr 1:119,368,779...119,394,130
JBrowse link
G HBA1 hemoglobin subunit alpha 1 multiple interactions ISO coumarin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased glycosylation of HBA1 protein] CTD PMID:19647726 NCBI chr16:176,680...177,522
Ensembl chr16:176,680...177,522
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha increases expression EXP coumarin analog results in increased expression of HIF1A mRNA CTD PMID:32578917 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HLA-DMA major histocompatibility complex, class II, DM alpha increases expression ISO coumarin results in increased expression of HLA-DMA mRNA CTD PMID:18480146 NCBI chr 6:32,948,618...32,953,097
Ensembl chr 6:32,948,613...32,969,094
JBrowse link
G HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 increases expression ISO coumarin results in increased expression of RT1-BA mRNA CTD PMID:18480146 NCBI chr 6:32,637,406...32,654,846
Ensembl chr 6:32,628,179...32,647,062
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO coumarin results in increased expression of HMGCR mRNA CTD PMID:18480146 NCBI chr 5:75,336,334...75,362,116
Ensembl chr 5:75,336,329...75,362,101
JBrowse link
G HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 multiple interactions EXP coumarin analog inhibits the reaction [[HSD17B1 protein co-treated with NADP] results in increased reduction of Estrone] CTD PMID:21232530 NCBI chr17:42,552,923...42,555,214
Ensembl chr17:42,552,922...42,555,214
Ensembl chr17:42,552,922...42,555,214
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 increases expression ISO coumarin results in increased expression of HSP90B1 mRNA CTD PMID:18480146 NCBI chr12:103,930,410...103,947,926
Ensembl chr12:103,930,107...103,953,645
JBrowse link
G HSPA1B heat shock protein family A (Hsp70) member 1B increases expression ISO coumarin results in increased expression of HSPA1B mRNA CTD PMID:18480146 NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254
JBrowse link
G HYOU1 hypoxia up-regulated 1 increases expression ISO coumarin results in increased expression of HYOU1 mRNA CTD PMID:18480146 NCBI chr11:119,044,187...119,057,205
Ensembl chr11:119,044,188...119,057,227
JBrowse link
G IGFALS insulin like growth factor binding protein acid labile subunit decreases expression ISO coumarin results in decreased expression of IGFALS mRNA CTD PMID:18480146 NCBI chr16:1,790,413...1,794,908
Ensembl chr16:1,790,413...1,794,971
JBrowse link
G IL1B interleukin 1 beta increases expression
decreases expression
ISO
EXP
coumarin results in increased expression of IL1B mRNA
coumarin analog results in decreased expression of IL1B protein
CTD PMID:15135310, PMID:32578917 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 increases expression
decreases expression
ISO
EXP
coumarin results in increased expression of IL6 mRNA
coumarin analog results in decreased expression of IL6 mRNA; coumarin analog results in decreased expression of IL6 protein
CTD PMID:15135310, PMID:32578917 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ISYNA1 inositol-3-phosphate synthase 1 increases expression ISO coumarin results in increased expression of ISYNA1 mRNA CTD PMID:18480146 NCBI chr19:18,434,388...18,438,649
Ensembl chr19:18,434,388...18,438,167
JBrowse link
G JOSD2 Josephin domain containing 2 increases expression ISO coumarin results in increased expression of JOSD2 mRNA CTD PMID:18480146 NCBI chr19:50,505,998...50,511,204
Ensembl chr19:50,505,998...50,511,353
Ensembl chr19:50,505,998...50,511,353
JBrowse link
G KCNK2 potassium two pore domain channel subfamily K member 2 increases expression ISO coumarin results in increased expression of KCNK2 mRNA CTD PMID:18480146 NCBI chr 1:215,002,920...215,237,093
Ensembl chr 1:215,005,775...215,237,090
Ensembl chr 1:215,005,775...215,237,090
JBrowse link
G KDR kinase insert domain receptor increases expression EXP coumarin analog results in increased expression of KDR mRNA CTD PMID:32578917 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595
JBrowse link
G KIF20A kinesin family member 20A decreases expression ISO coumarin results in decreased expression of KIF20A mRNA CTD PMID:18480146 NCBI chr 5:138,179,112...138,187,723
Ensembl chr 5:138,178,719...138,187,723
JBrowse link
G KLF2 Kruppel like factor 2 decreases expression ISO coumarin results in decreased expression of KLF2 mRNA CTD PMID:18480146 NCBI chr19:16,324,826...16,328,685
Ensembl chr19:16,324,817...16,327,874
Ensembl chr19:16,324,817...16,327,874
JBrowse link
G KRT19 keratin 19 decreases expression ISO coumarin results in decreased expression of KRT19 mRNA CTD PMID:18480146 NCBI chr17:41,523,617...41,528,308
Ensembl chr17:41,523,617...41,528,308
JBrowse link
G KYNU kynureninase decreases expression ISO coumarin results in decreased expression of KYNU mRNA CTD PMID:18480146 NCBI chr 2:142,877,664...143,055,833
Ensembl chr 2:142,877,657...143,055,833
JBrowse link
G LAD1 ladinin 1 increases expression ISO coumarin results in increased expression of LAD1 mRNA CTD PMID:18480146 NCBI chr 1:201,380,833...201,399,324
Ensembl chr 1:201,380,833...201,399,915
JBrowse link
G LMF2 lipase maturation factor 2 increases expression ISO coumarin results in increased expression of LMF2 mRNA CTD PMID:18480146 NCBI chr22:50,502,949...50,507,781
Ensembl chr22:50,502,949...50,507,702
JBrowse link
G LOC389895 chromosome 16 open reading frame 72-like increases expression ISO coumarin results in increased expression of RGD1560171 mRNA CTD PMID:18480146 NCBI chr  X:140,091,667...140,092,911 JBrowse link
G LRP3 LDL receptor related protein 3 affects expression ISO coumarin affects the expression of LRP3 mRNA CTD PMID:16963487 NCBI chr19:33,194,330...33,208,864
Ensembl chr19:33,177,603...33,208,864
JBrowse link
G MAT1A methionine adenosyltransferase 1A affects expression ISO coumarin affects the expression of MAT1A mRNA CTD PMID:16963487 NCBI chr10:80,271,820...80,289,658
Ensembl chr10:80,271,820...80,289,658
JBrowse link
G MBL2 mannose binding lectin 2 decreases expression ISO coumarin results in decreased expression of MBL2 mRNA CTD PMID:18480146 NCBI chr10:52,765,380...52,772,784
Ensembl chr10:52,765,380...52,772,784
Ensembl chr10:52,765,380...52,772,784
JBrowse link
G MCM2 minichromosome maintenance complex component 2 increases expression ISO coumarin results in increased expression of MCM2 mRNA CTD PMID:18480146 NCBI chr 3:127,598,411...127,622,436
Ensembl chr 3:127,598,410...127,622,436
JBrowse link
G MCM3 minichromosome maintenance complex component 3 increases expression ISO coumarin results in increased expression of MCM3 mRNA CTD PMID:18480146 NCBI chr 6:52,264,015...52,284,742
Ensembl chr 6:52,264,014...52,284,881
JBrowse link
G MCM4 minichromosome maintenance complex component 4 increases expression ISO coumarin results in increased expression of MCM4 mRNA CTD PMID:18480146 NCBI chr 8:47,960,941...47,978,160
Ensembl chr 8:47,960,185...47,978,160
JBrowse link
G MCM5 minichromosome maintenance complex component 5 increases expression ISO coumarin results in increased expression of MCM5 mRNA CTD PMID:18480146 NCBI chr22:35,400,133...35,454,942
Ensembl chr22:35,400,134...35,425,431
JBrowse link
G MDM2 MDM2 proto-oncogene decreases expression EXP coumarin analog results in decreased expression of MDM2 mRNA CTD PMID:32578917 NCBI chr12:68,808,149...68,850,686
Ensembl chr12:68,808,177...68,850,686
JBrowse link
G MGP matrix Gla protein decreases expression EXP
ISO
coumarin results in decreased expression of MGP mRNA CTD PMID:19350115 NCBI chr12:14,880,864...14,885,854
Ensembl chr12:14,880,864...14,885,857
JBrowse link
G MGST2 microsomal glutathione S-transferase 2 increases expression ISO coumarin results in increased expression of MGST2 mRNA CTD PMID:18480146 NCBI chr 4:139,665,725...139,754,608
Ensembl chr 4:139,665,768...139,740,745
JBrowse link
G MGST3 microsomal glutathione S-transferase 3 decreases expression ISO coumarin results in decreased expression of MGST3 mRNA CTD PMID:18480146 NCBI chr 1:165,631,234...165,656,136
Ensembl chr 1:165,631,213...165,661,796
JBrowse link
G MMP2 matrix metallopeptidase 2 decreases expression EXP coumarin analog results in decreased expression of MMP2 mRNA CTD PMID:32578917 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
decreases expression
EXP coumarin analog results in decreased expression of and results in decreased activity of MMP9 protein
coumarin analog results in decreased expression of MMP9 mRNA
CTD PMID:32578917 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MMS22L MMS22 like, DNA repair protein increases expression ISO coumarin results in increased expression of MMS22L mRNA CTD PMID:18480146 NCBI chr 6:97,142,161...97,283,437
Ensembl chr 6:97,142,161...97,283,217
JBrowse link
G MSMO1 methylsterol monooxygenase 1 affects expression ISO coumarin affects the expression of MSMO1 mRNA CTD PMID:16963487 NCBI chr 4:165,327,669...165,343,164
Ensembl chr 4:165,327,667...165,343,164
JBrowse link
G MT1A metallothionein 1A increases expression ISO coumarin results in increased expression of MT1A mRNA CTD PMID:18480146 NCBI chr16:56,638,666...56,640,087
Ensembl chr16:56,638,666...56,640,087
JBrowse link
G MT2A metallothionein 2A increases expression ISO coumarin results in increased expression of MT2A mRNA CTD PMID:18480146 NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497
JBrowse link
G NECTIN2 nectin cell adhesion molecule 2 decreases expression ISO coumarin results in decreased expression of NECTIN2 mRNA CTD PMID:18480146 NCBI chr19:44,846,297...44,889,223
Ensembl chr19:44,846,175...44,889,223
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 affects activity
increases activity
ISO coumarin affects the activity of NFE2L2 protein
coumarin results in increased activity of NFE2L2 protein
CTD PMID:11309284, PMID:30114225, PMID:30203046 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NOL3 nucleolar protein 3 increases expression ISO coumarin results in increased expression of NOL3 mRNA CTD PMID:18480146 NCBI chr16:67,170,538...67,175,737
Ensembl chr16:67,170,154...67,175,735
JBrowse link
G NOL8 nucleolar protein 8 increases expression ISO coumarin results in increased expression of NOL8 mRNA CTD PMID:18480146 NCBI chr 9:92,297,358...92,325,994
Ensembl chr 9:92,297,358...92,325,636
JBrowse link
G NOP56 NOP56 ribonucleoprotein increases expression ISO coumarin results in increased expression of NOP56 mRNA CTD PMID:18480146 NCBI chr20:2,652,632...2,658,393
Ensembl chr20:2,652,593...2,658,393
JBrowse link
G NOS2 nitric oxide synthase 2 increases expression ISO
EXP
coumarin results in increased expression of NOS2 mRNA
coumarin analog results in increased expression of NOS2 mRNA; coumarin analog results in increased expression of NOS2 protein
CTD PMID:15135310, PMID:32578917 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression ISO coumarin results in increased expression of NQO1 mRNA; coumarin results in increased expression of NQO1 protein CTD PMID:11309284, PMID:17311802, PMID:18480146 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 increases expression ISO coumarin results in increased expression of NR0B2 mRNA CTD PMID:18480146 NCBI chr 1:26,911,489...26,914,110
Ensembl chr 1:26,911,489...26,913,975
JBrowse link
G NR1D2 nuclear receptor subfamily 1 group D member 2 increases expression ISO coumarin results in increased expression of NR1D2 mRNA CTD PMID:18480146 NCBI chr 3:23,945,286...23,980,618
Ensembl chr 3:23,945,286...23,980,617
JBrowse link
G NREP neuronal regeneration related protein decreases expression ISO coumarin results in decreased expression of NREP mRNA CTD PMID:18480146 NCBI chr 5:111,728,802...111,976,932
Ensembl chr 5:111,662,621...111,997,464
JBrowse link
G NRTN neurturin increases expression ISO coumarin results in increased expression of NRTN mRNA CTD PMID:18480146 NCBI chr19:5,805,067...5,828,324
Ensembl chr19:5,823,802...5,828,324
JBrowse link
G NTNG1 netrin G1 decreases expression ISO coumarin results in decreased expression of NTNG1 mRNA CTD PMID:18480146 NCBI chr 1:107,140,017...107,484,923
Ensembl chr 1:107,140,007...107,483,458
JBrowse link
G NUPR1 nuclear protein 1, transcriptional regulator increases expression ISO coumarin results in increased expression of NUPR1 mRNA CTD PMID:18480146 NCBI chr16:28,532,708...28,538,974
Ensembl chr16:28,532,708...28,539,174
Ensembl chr16:28,532,708...28,539,174
JBrowse link
G OAF out at first homolog decreases expression ISO coumarin results in decreased expression of OAF mRNA CTD PMID:18480146 NCBI chr11:120,211,032...120,230,334
Ensembl chr11:120,211,032...120,230,334
JBrowse link
G OAT ornithine aminotransferase decreases expression ISO coumarin results in decreased expression of OAT mRNA CTD PMID:18480146 NCBI chr10:124,397,303...124,418,923
Ensembl chr10:124,397,303...124,418,976
JBrowse link
G OGN osteoglycin decreases expression ISO coumarin results in decreased expression of OGN mRNA CTD PMID:18480146 NCBI chr 9:92,383,268...92,404,699
Ensembl chr 9:92,383,268...92,404,696
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 decreases activity
decreases expression
increases cleavage
multiple interactions
EXP coumarin results in decreased activity of PARP1 protein
coumarin analog results in decreased expression of PARP1 mRNA
coumarin analog results in increased cleavage of PARP1 protein
[coumarin results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NAD]; [coumarin results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NADP]
CTD PMID:17669606, PMID:31199928, PMID:32578917 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial increases expression ISO coumarin results in increased expression of PCK2 mRNA CTD PMID:18480146 NCBI chr14:24,094,311...24,104,125
Ensembl chr14:24,094,053...24,110,598
JBrowse link
G PCNA proliferating cell nuclear antigen increases expression EXP coumarin analog results in increased expression of PCNA mRNA CTD PMID:32578917 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PDE4B phosphodiesterase 4B decreases expression ISO coumarin results in decreased expression of PDE4B mRNA CTD PMID:18480146 NCBI chr 1:65,792,510...66,374,579
Ensembl chr 1:65,792,514...66,374,579
JBrowse link
G PDIA3 protein disulfide isomerase family A member 3 increases expression ISO coumarin results in increased expression of PDIA3 mRNA CTD PMID:18480146 NCBI chr15:43,746,438...43,773,278
Ensembl chr15:43,746,410...43,773,278
JBrowse link
G PDIA4 protein disulfide isomerase family A member 4 increases expression ISO coumarin results in increased expression of PDIA4 mRNA CTD PMID:18480146 NCBI chr 7:149,003,051...149,028,505
Ensembl chr 7:149,003,062...149,028,662
JBrowse link
G PDK2 pyruvate dehydrogenase kinase 2 decreases expression ISO coumarin results in decreased expression of PDK2 mRNA CTD PMID:18480146 NCBI chr17:50,094,737...50,112,152
Ensembl chr17:50,094,737...50,112,152
JBrowse link
G PLA2G12A phospholipase A2 group XIIA increases expression ISO coumarin results in increased expression of PLA2G12A mRNA CTD PMID:18480146 NCBI chr 4:109,709,989...109,730,070
Ensembl chr 4:109,709,989...109,730,070
JBrowse link
G POLD1 DNA polymerase delta 1, catalytic subunit increases expression ISO coumarin results in increased expression of POLD1 mRNA CTD PMID:18480146 NCBI chr19:50,384,291...50,418,018
Ensembl chr19:50,384,204...50,418,018
JBrowse link
G POLD2 DNA polymerase delta 2, accessory subunit increases expression ISO coumarin results in increased expression of POLD2 mRNA CTD PMID:18480146 NCBI chr 7:44,114,680...44,123,668
Ensembl chr 7:44,114,681...44,124,358
JBrowse link
G POLR1E RNA polymerase I subunit E increases expression ISO coumarin results in increased expression of POLR1E mRNA CTD PMID:18480146 NCBI chr 9:37,485,948...37,503,697
Ensembl chr 9:37,485,948...37,503,697
JBrowse link
G PTGR1 prostaglandin reductase 1 increases expression ISO coumarin results in increased expression of PTGR1 mRNA CTD PMID:18480146 NCBI chr 9:111,549,722...111,599,855
Ensembl chr 9:111,549,722...111,599,893
JBrowse link
G R3HDM1 R3H domain containing 1 increases expression ISO coumarin results in increased expression of R3HDM1 mRNA CTD PMID:18480146 NCBI chr 2:135,531,429...135,725,270
Ensembl chr 2:135,531,455...135,725,270
JBrowse link
G R3HDM2 R3H domain containing 2 decreases expression ISO coumarin results in decreased expression of R3HDM2 mRNA CTD PMID:18480146 NCBI chr12:57,253,764...57,431,043
Ensembl chr12:57,253,762...57,431,005
JBrowse link
G RAB3D RAB3D, member RAS oncogene family increases expression ISO coumarin results in increased expression of RAB3D mRNA CTD PMID:18480146 NCBI chr19:11,322,068...11,339,657
Ensembl chr19:11,322,068...11,346,270
JBrowse link
G RBM3 RNA binding motif protein 3 increases expression ISO coumarin results in increased expression of RBM3 mRNA CTD PMID:18480146 NCBI chr  X:48,574,479...48,581,162
Ensembl chr  X:48,574,449...48,581,162
JBrowse link
G RBP1 retinol binding protein 1 decreases expression ISO coumarin results in decreased expression of RBP1 mRNA CTD PMID:18480146 NCBI chr 3:139,517,438...139,539,742
Ensembl chr 3:139,517,434...139,539,829
JBrowse link
G RGN regucalcin decreases expression ISO coumarin results in decreased expression of RGN mRNA CTD PMID:18480146 NCBI chr  X:47,078,414...47,093,313
Ensembl chr  X:47,078,355...47,093,314
JBrowse link
G RGS8 regulator of G protein signaling 8 decreases expression ISO coumarin results in decreased expression of RGS8 mRNA CTD PMID:18480146 NCBI chr 1:182,641,814...182,753,293
Ensembl chr 1:182,641,816...182,684,576
JBrowse link
G RPRM reprimo, TP53 dependent G2 arrest mediator homolog decreases expression ISO coumarin results in decreased expression of RPRM mRNA CTD PMID:18480146 NCBI chr 2:153,477,338...153,478,762
Ensembl chr 2:153,477,338...153,478,762
JBrowse link
G SARAF store-operated calcium entry associated regulatory factor increases expression ISO coumarin results in increased expression of SARAF mRNA CTD PMID:18480146 NCBI chr 8:30,063,003...30,083,208
Ensembl chr 8:30,063,003...30,083,208
JBrowse link
G SCD stearoyl-CoA desaturase decreases expression ISO coumarin results in decreased expression of SCD1 mRNA CTD PMID:18480146 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826
JBrowse link
G SDF2L1 stromal cell derived factor 2 like 1 increases expression ISO coumarin results in increased expression of SDF2L1 mRNA CTD PMID:18480146 NCBI chr22:21,642,302...21,644,299
Ensembl chr22:21,642,302...21,644,299
JBrowse link
G SEL1L SEL1L adaptor subunit of ERAD E3 ubiquitin ligase increases expression ISO coumarin results in increased expression of SEL1L mRNA CTD PMID:18480146 NCBI chr14:81,471,547...81,533,853
Ensembl chr14:81,471,547...81,533,853
JBrowse link
G SEMA6D semaphorin 6D increases expression ISO coumarin results in increased expression of SEMA6D mRNA CTD PMID:18480146 NCBI chr15:47,184,089...47,774,228
Ensembl chr15:47,184,101...47,774,223
Ensembl chr15:47,184,101...47,774,223
JBrowse link
G SLC17A1 solute carrier family 17 member 1 increases expression ISO coumarin results in increased expression of SLC17A1 mRNA CTD PMID:18480146 NCBI chr 6:25,723,743...25,832,108
Ensembl chr 6:25,782,915...25,832,052
Ensembl chr 6:25,782,915...25,832,052
JBrowse link
G SLC17A3 solute carrier family 17 member 3 increases expression ISO coumarin results in increased expression of SLC17A3 mRNA CTD PMID:18480146 NCBI chr 6:25,844,856...25,874,243
Ensembl chr 6:25,833,066...25,882,286
JBrowse link
G SLC1A2 solute carrier family 1 member 2 increases expression ISO coumarin results in increased expression of SLC1A2 mRNA CTD PMID:18480146 NCBI chr11:35,251,205...35,420,058
Ensembl chr11:35,251,205...35,420,063
JBrowse link
G SLC27A2 solute carrier family 27 member 2 affects expression ISO coumarin affects the expression of SLC27A2 mRNA CTD PMID:16963487 NCBI chr15:50,182,196...50,236,385
Ensembl chr15:50,182,196...50,236,385
JBrowse link
G SLC28A2 solute carrier family 28 member 2 decreases expression ISO coumarin results in decreased expression of SLC28A2 mRNA CTD PMID:18480146 NCBI chr15:45,252,234...45,277,846
Ensembl chr15:45,252,234...45,277,846
JBrowse link
G SLC35E3 solute carrier family 35 member E3 increases expression ISO coumarin results in increased expression of SLC35E3 mRNA CTD PMID:18480146 NCBI chr12:68,746,176...68,781,468
Ensembl chr12:68,746,125...68,793,964
Ensembl chr12:68,746,125...68,793,964
JBrowse link
G SLC6A13 solute carrier family 6 member 13 decreases expression ISO coumarin results in decreased expression of SLC6A13 mRNA CTD PMID:18480146 NCBI chr12:220,622...262,930
Ensembl chr12:220,621...262,873
JBrowse link
G SLC6A9 solute carrier family 6 member 9 increases expression ISO coumarin results in increased expression of SLC6A9 mRNA CTD PMID:18480146 NCBI chr 1:43,996,483...44,031,462
Ensembl chr 1:43,991,500...44,031,467
JBrowse link
G SMPDL3B sphingomyelin phosphodiesterase acid like 3B increases expression ISO coumarin results in increased expression of SMPDL3B mRNA CTD PMID:18480146 NCBI chr 1:27,934,955...27,959,152
Ensembl chr 1:27,935,000...27,959,157
JBrowse link
G SNAI2 snail family transcriptional repressor 2 decreases expression EXP coumarin analog results in decreased expression of SNAI2 mRNA CTD PMID:32578917 NCBI chr 8:48,917,598...48,921,429
Ensembl chr 8:48,917,598...48,921,740
JBrowse link
G SRXN1 sulfiredoxin 1 increases expression ISO coumarin results in increased expression of SRXN1 mRNA CTD PMID:18480146 NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,370
Ensembl chr20:646,615...653,370
JBrowse link
G STAT5B signal transducer and activator of transcription 5B increases activity ISO coumarin results in increased activity of STAT5B protein CTD PMID:30114225 NCBI chr17:42,199,177...42,288,437
Ensembl chr17:42,199,177...42,276,707
Ensembl chr17:42,199,177...42,276,707
JBrowse link
G SULT1B1 sulfotransferase family 1B member 1 affects expression ISO coumarin affects the expression of SULT1B1 mRNA CTD PMID:16963487 NCBI chr 4:69,721,167...69,760,644
Ensembl chr 4:69,721,167...69,787,961
JBrowse link
G SULT1C3 sulfotransferase family 1C member 3 decreases expression ISO coumarin results in decreased expression of SULT1C1 mRNA CTD PMID:18480146 NCBI chr 2:108,239,968...108,265,608
Ensembl chr 2:108,247,195...108,265,351
JBrowse link
G SULT1E1 sulfotransferase family 1E member 1 decreases expression ISO coumarin results in decreased expression of SULT1E1 mRNA CTD PMID:18480146 NCBI chr 4:69,841,212...69,860,151
Ensembl chr 4:69,841,212...69,860,145
JBrowse link
G SYCP3 synaptonemal complex protein 3 decreases expression ISO coumarin results in decreased expression of SYCP3 mRNA CTD PMID:18480146 NCBI chr12:101,728,648...101,739,721
Ensembl chr12:101,728,648...101,739,472
JBrowse link
G SYNE4 spectrin repeat containing nuclear envelope family member 4 increases expression ISO coumarin results in increased expression of SYNE4 mRNA CTD PMID:18480146 NCBI chr19:36,003,307...36,008,813
Ensembl chr19:36,003,307...36,008,813
JBrowse link
G TFRC transferrin receptor increases expression ISO coumarin results in increased expression of TFRC mRNA CTD PMID:18480146 NCBI chr 3:196,018,694...196,082,123
Ensembl chr 3:196,027,183...196,082,096
JBrowse link
G TGFB1 transforming growth factor beta 1 increases expression EXP coumarin analog results in increased expression of TGFB1 mRNA CTD PMID:32578917 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G THRA thyroid hormone receptor alpha increases expression ISO coumarin results in increased expression of THRA mRNA CTD PMID:18480146 NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867
JBrowse link
G THRSP thyroid hormone responsive affects expression
decreases expression
ISO coumarin affects the expression of THRSP mRNA
coumarin results in decreased expression of THRSP mRNA
CTD PMID:16963487, PMID:18480146 NCBI chr11:78,063,861...78,068,351
Ensembl chr11:78,063,861...78,068,351
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 increases expression EXP coumarin analog results in increased expression of TIMP2 mRNA CTD PMID:32578917 NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387
JBrowse link
G TIMP4 TIMP metallopeptidase inhibitor 4 increases expression EXP coumarin analog results in increased expression of TIMP4 mRNA CTD PMID:32578917 NCBI chr 3:12,153,068...12,158,912
Ensembl chr 3:12,153,068...12,158,912
JBrowse link
G TMED3 transmembrane p24 trafficking protein 3 increases expression ISO coumarin results in increased expression of TMED3 mRNA CTD PMID:18480146 NCBI chr15:79,311,112...79,413,886
Ensembl chr15:79,311,112...79,427,432
JBrowse link
G TNF tumor necrosis factor increases expression ISO
EXP
coumarin results in increased expression of TNF mRNA
coumarin analog results in increased expression of TNF protein
CTD PMID:15135310, PMID:32578917 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF9 TNF receptor superfamily member 9 decreases expression ISO coumarin results in decreased expression of TNFRSF9 mRNA CTD PMID:18480146 NCBI chr 1:7,915,871...7,941,607
Ensembl chr 1:7,915,894...7,943,165
Ensembl chr 1:7,915,894...7,943,165
JBrowse link
G TP53 tumor protein p53 increases expression EXP coumarin analog results in increased expression of TP53 mRNA; coumarin analog results in increased expression of TP53 protein CTD PMID:32578917 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TRADD TNFRSF1A associated via death domain increases expression EXP coumarin analog results in increased expression of TRADD mRNA CTD PMID:32578917 NCBI chr16:67,154,185...67,159,909
Ensembl chr16:67,154,185...67,159,909
JBrowse link
G TRPC2 transient receptor potential cation channel subfamily C member 2 (pseudogene) increases expression ISO coumarin results in increased expression of TRPC2 mRNA CTD PMID:18480146 NCBI chr11:3,626,460...3,637,559
Ensembl chr11:3,609,901...3,637,559
JBrowse link
G TSC22D1 TSC22 domain family member 1 decreases expression ISO coumarin results in decreased expression of TSC22D1 mRNA CTD PMID:18480146 NCBI chr13:44,432,143...44,576,825
Ensembl chr13:44,432,143...44,577,147
JBrowse link
G TST thiosulfate sulfurtransferase affects expression ISO coumarin affects the expression of TST mRNA CTD PMID:16963487 NCBI chr22:37,010,859...37,020,183
Ensembl chr22:37,010,859...37,020,183
JBrowse link
G TTC39A tetratricopeptide repeat domain 39A increases expression ISO coumarin results in increased expression of TTC39A mRNA CTD PMID:18480146 NCBI chr 1:51,287,258...51,345,116
Ensembl chr 1:51,287,258...51,345,116
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression ISO coumarin results in increased expression of TXNRD1 mRNA CTD PMID:18480146 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G UGDH UDP-glucose 6-dehydrogenase increases expression ISO coumarin results in increased expression of UGDH mRNA CTD PMID:18480146 NCBI chr 4:39,498,755...39,527,439
Ensembl chr 4:39,498,755...39,528,311
JBrowse link
G VEGFA vascular endothelial growth factor A increases expression EXP coumarin analog results in increased expression of VEGFA mRNA CTD PMID:32578917 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G VIM vimentin decreases expression EXP coumarin analog results in decreased expression of VIM protein CTD PMID:32578917 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
JBrowse link
G VKORC1 vitamin K epoxide reductase complex subunit 1 decreases response to substance
increases response to substance
EXP VKORC1 gene mutant form results in decreased susceptibility to coumarin
VKORC1 gene mutant form results in increased susceptibility to coumarin; VKORC1 promoter SNP results in increased susceptibility to coumarin
CTD PMID:17849045, PMID:18278162 NCBI chr16:31,090,854...31,094,797
Ensembl chr16:31,090,842...31,095,980
JBrowse link
G WEE1 WEE1 G2 checkpoint kinase increases expression ISO coumarin results in increased expression of WEE1 mRNA CTD PMID:18480146 NCBI chr11:9,573,670...9,589,985
Ensembl chr11:9,573,670...9,593,457
JBrowse link
G YRDC yrdC N6-threonylcarbamoyltransferase domain containing increases expression ISO coumarin results in increased expression of YRDC mRNA CTD PMID:18480146 NCBI chr 1:37,802,945...37,808,208
Ensembl chr 1:37,802,945...37,808,208
JBrowse link
G ZEB1 zinc finger E-box binding homeobox 1 decreases expression EXP coumarin analog results in decreased expression of ZEB1 mRNA CTD PMID:32578917 NCBI chr10:31,318,417...31,529,804
Ensembl chr10:31,318,495...31,529,814
JBrowse link
G ZNF444 zinc finger protein 444 increases expression ISO coumarin results in increased expression of ZFP444 mRNA CTD PMID:18480146 NCBI chr19:56,132,509...56,160,893
Ensembl chr19:56,132,599...56,160,893
JBrowse link
G ZNF593 zinc finger protein 593 increases expression ISO coumarin results in increased expression of ZNF593 mRNA CTD PMID:18480146 NCBI chr 1:26,169,908...26,170,873
Ensembl chr 1:26,169,908...26,170,873
JBrowse link
G ZWINT ZW10 interacting kinetochore protein increases expression ISO coumarin results in increased expression of ZWINT mRNA CTD PMID:18480146 NCBI chr10:56,357,227...56,361,273
Ensembl chr10:56,357,227...56,361,273
JBrowse link
coumarin 460 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKAP9 A-kinase anchoring protein 9 increases expression EXP 4-methyl-7-diethylaminocoumarin results in increased expression of AKAP9 mRNA CTD PMID:19502547 NCBI chr 7:91,940,862...92,112,908
Ensembl chr 7:91,940,867...92,110,673
Ensembl chr 7:91,940,867...92,110,673
JBrowse link
G ANKRD37 ankyrin repeat domain 37 increases expression EXP 4-methyl-7-diethylaminocoumarin results in increased expression of ANKRD37 mRNA CTD PMID:19502547 NCBI chr 4:185,396,841...185,400,243
Ensembl chr 4:185,396,021...185,400,628
JBrowse link
G AR androgen receptor affects localization
multiple interactions
EXP 4-methyl-7-diethylaminocoumarin affects the localization of AR protein
4-methyl-7-diethylaminocoumarin binds to and results in increased activity of AR protein
CTD PMID:28478275 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha increases activity EXP 4-methyl-7-diethylaminocoumarin results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G PFKM phosphofructokinase, muscle increases expression EXP 4-methyl-7-diethylaminocoumarin results in increased expression of PFKM mRNA