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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:azacycloalkane
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Accession:CHEBI:37949 term browser browse the term
Synonyms:related_synonym: azacycloalkanes


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azetidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO azetidine inhibits the reaction [Adenosine Triphosphate results in increased secretion of CCL3 protein] CTD PMID:26522449 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ctsb cathepsin B multiple interactions ISO azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of CTSB protein] CTD PMID:26522449 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO azetidine inhibits the reaction [Adenosine Triphosphate results in increased secretion of CXCL2 protein] CTD PMID:26522449 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Il6 interleukin 6 multiple interactions ISO azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein] CTD PMID:26522449 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein] CTD PMID:26522449 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein] CTD PMID:26522449 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of MMP9 protein] CTD PMID:26522449 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO azetidine analog inhibits the reaction [Adenosine Triphosphate affects the localization of NFATC1 protein] CTD PMID:26522449 NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of NOS2 protein] CTD PMID:26522449 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G P2rx7 purinergic receptor P2X 7 multiple interactions ISO azetidine analog inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased expression of P2RX7 protein]; azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of P2RX7 protein] CTD PMID:26522449 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO azetidine analog inhibits the reaction [Adenosine Triphosphate results in decreased secretion of TIMP1 protein] CTD PMID:26522449 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO azetidine analog inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of TNF protein]; azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased secretion of TNF protein] CTD PMID:26522449 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 affects localization ISO azetidine affects the localization of TRP53 protein CTD PMID:18813348 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
azetidinecarboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cryab crystallin, alpha B increases expression ISO Azetidinecarboxylic Acid results in increased expression of CRYAB protein CTD PMID:8113214 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Azetidinecarboxylic Acid results in increased expression of HSPA1A mRNA CTD PMID:12085988 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO Azetidinecarboxylic Acid results in increased expression of HSPA1B mRNA CTD PMID:12085988 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO Azetidinecarboxylic Acid results in increased expression of HSPB1 protein CTD PMID:8113214 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
guanethidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Guanethidine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant affects expression
increases expression
EXP Guanethidine affects the expression of ACP5 protein
Guanethidine results in increased expression of ACP5 mRNA
CTD PMID:14527964 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Ctsk cathepsin K increases expression
affects expression
EXP Guanethidine results in increased expression of CTSK mRNA
Guanethidine affects the expression of CTSK protein
CTD PMID:14527964 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP Guanethidine inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A2 protein] CTD PMID:16510159 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression EXP Guanethidine results in increased expression of MMP13 mRNA CTD PMID:14527964 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Npy neuropeptide Y decreases expression
decreases secretion
EXP
ISO
Guanethidine results in decreased expression of NPY protein
Guanethidine results in decreased secretion of NPY protein
CTD PMID:9460767, PMID:14527964, PMID:15003356 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Guanethidine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA] CTD PMID:15850565 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Th tyrosine hydroxylase decreases expression EXP Guanethidine results in decreased expression of TH protein CTD PMID:9460767 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Vip vasoactive intestinal peptide decreases expression EXP Guanethidine results in decreased expression of VIP protein CTD PMID:14527964 NCBI chr 1:42,169,307...42,177,582
Ensembl chr 1:42,169,501...42,177,582
JBrowse link
N-nitrosopiperidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO CYP2E1 protein affects the metabolism of and results in increased activity of N-nitrosopiperidine CTD PMID:11774366 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO N-nitrosopiperidine results in increased cleavage of PARP1 protein CTD PMID:17929238 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
phencyclidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor decreases expression ISO Phencyclidine results in decreased expression of ADORA2A mRNA CTD PMID:17266109 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Ajuba ajuba LIM protein increases expression ISO Phencyclidine results in increased expression of AJUBA mRNA CTD PMID:12105081 NCBI chr15:33,208,210...33,218,456
Ensembl chr15:33,208,216...33,218,456
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO Phencyclidine results in increased expression of ALDH1A1 mRNA CTD PMID:17266109 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Apod apolipoprotein D increases expression ISO Phencyclidine results in increased expression of APOD mRNA CTD PMID:17266109 NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
JBrowse link
G Arhgef9 Cdc42 guanine nucleotide exchange factor 9 decreases expression ISO Phencyclidine results in decreased expression of ARHGEF9 mRNA CTD PMID:17266109 NCBI chr  X:64,249,576...64,428,444
Ensembl chr  X:64,248,278...64,428,592
JBrowse link
G Calm1 calmodulin 1 decreases expression ISO Phencyclidine results in decreased expression of CALM1 mRNA CTD PMID:17205118 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Calm2 calmodulin 2 decreases expression ISO Phencyclidine results in decreased expression of CALM2 mRNA CTD PMID:17205118 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha increases expression
decreases expression
ISO Phencyclidine results in increased expression of CAMK2A mRNA
Phencyclidine results in decreased expression of CAMK2A mRNA
CTD PMID:17266109 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta decreases expression ISO Phencyclidine results in decreased expression of CAMK2B mRNA CTD PMID:17205118 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652
JBrowse link
G Casp1 caspase 1 increases expression ISO Phencyclidine results in increased expression of CASP1 mRNA CTD PMID:12105081 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]]; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]; Cadmium Chloride inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]]; Nifedipine inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]]; omega-agatoxin-Aa4b inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]]; staurosporine aglycone inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]] CTD PMID:24995437 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cckbr cholecystokinin B receptor increases expression ISO Phencyclidine results in increased expression of CCKBR mRNA CTD PMID:17266109 NCBI chr 1:170,262,218...170,272,298
Ensembl chr 1:170,262,156...170,272,298
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases expression ISO Phencyclidine results in increased expression of CDK5R1 mRNA CTD PMID:17266109 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase decreases expression
increases expression
ISO Phencyclidine results in decreased expression of CNP mRNA
Phencyclidine results in increased expression of CNP mRNA
CTD PMID:17266109 NCBI chr10:88,490,798...88,497,357
Ensembl chr10:88,490,798...88,497,356
JBrowse link
G Cplx2 complexin 2 decreases expression ISO Phencyclidine results in decreased expression of CPLX2 mRNA CTD PMID:17266109 NCBI chr17:10,756,871...10,828,811
Ensembl chr17:10,756,285...10,818,835
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
increases activity
ISO acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; ginsenoside Re inhibits the reaction [Phencyclidine results in increased activity of CYBA protein]; GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein] CTD PMID:29037473 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity
affects metabolic processing
affects oxidation
ISO Phencyclidine analog results in decreased activity of CYP2B6 protein; Phencyclidine results in decreased activity of CYP2B6 protein
CYP2B6 protein affects the metabolism of Phencyclidine analog
CYP2B6 protein affects the oxidation of Phencyclidine
CTD PMID:16782764 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects oxidation
decreases activity
ISO CYP2C19 protein affects the oxidation of Phencyclidine
Phencyclidine results in decreased activity of CYP2C19 protein
CTD PMID:16782764 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects metabolic processing ISO CYP2C8 protein affects the metabolism of Phencyclidine CTD PMID:16782764 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing ISO CYP2D6 protein affects the metabolism of Phencyclidine CTD PMID:16782764 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing ISO CYP3A5 protein affects the metabolism of Phencyclidine CTD PMID:16782764 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Dnajc1 DnaJ heat shock protein family (Hsp40) member C1 decreases expression ISO Phencyclidine results in decreased expression of DNAJC1 mRNA CTD PMID:12105081 NCBI chr17:84,986,994...85,141,464
Ensembl chr17:84,986,991...85,141,210
JBrowse link
G Drd1 dopamine receptor D1 decreases expression
multiple interactions
ISO Phencyclidine results in decreased expression of DRD1 mRNA; Phencyclidine results in decreased expression of DRD1 protein
NTSR1 gene affects the reaction [Phencyclidine results in decreased expression of DRD1 protein]
CTD PMID:17266109, PMID:20659557 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 decreases expression ISO Phencyclidine results in decreased expression of DRD2 mRNA; Phencyclidine results in decreased expression of DRD2 protein CTD PMID:17266109, PMID:20659557 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Egf epidermal growth factor increases expression ISO Phencyclidine results in increased expression of EGF mRNA CTD PMID:12105081 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression ISO Phencyclidine results in increased expression of FDFT1 mRNA CTD PMID:17205118 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP [Dextroamphetamine co-treated with Phencyclidine] promotes the reaction [FOS protein binds to FOS promoter]; [Dextroamphetamine co-treated with Phencyclidine] promotes the reaction [SRF protein binds to FOS promoter]; [Dextroamphetamine co-treated with Phencyclidine] results in increased expression of FOS protein; [Phencyclidine co-treated with Dextroamphetamine] results in increased expression of FOS protein; Phencyclidine promotes the reaction [FOS protein binds to FOS promoter]; Phencyclidine promotes the reaction [SRF protein binds to FOS promoter]
Phencyclidine results in increased expression of FOS protein
CTD PMID:12510024, PMID:16678866 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP [Phencyclidine co-treated with Dextroamphetamine] results in increased expression of FOSB protein
Phencyclidine results in increased expression of FOSB protein
CTD PMID:16678866 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Foxp2 forkhead box P2 increases expression ISO Phencyclidine results in increased expression of FOXP2 mRNA CTD PMID:17266109 NCBI chr 4:41,364,441...41,944,685
Ensembl chr 4:41,364,441...41,942,023
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 decreases expression ISO Phencyclidine results in decreased expression of GABBR1 mRNA CTD PMID:17266109 NCBI chr20:1,955,344...1,984,907
Ensembl chr20:1,955,359...1,984,863
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 increases expression ISO Phencyclidine results in increased expression of GABRA1 mRNA CTD PMID:17266109 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gad2 glutamate decarboxylase 2 increases expression ISO Phencyclidine results in increased expression of GAD2 mRNA CTD PMID:17266109 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040
JBrowse link
G Gap43 growth associated protein 43 increases expression EXP Phencyclidine results in increased expression of GAP43 mRNA CTD PMID:11377751 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gcc1 GRIP and coiled-coil domain containing 1 increases expression ISO Phencyclidine results in increased expression of GCC1 mRNA CTD PMID:17205118 NCBI chr 4:55,708,040...55,719,884
Ensembl chr 4:55,709,096...55,713,620
JBrowse link
G Gfap glial fibrillary acidic protein increases expression ISO Phencyclidine results in increased expression of GFAP mRNA CTD PMID:17266109 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gnas GNAS complex locus increases expression ISO Phencyclidine results in increased expression of GNAS mRNA CTD PMID:12105081 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]; GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]; GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]; GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]; GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein] CTD PMID:29037473 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 increases expression ISO Phencyclidine results in increased expression of GRIA4 mRNA CTD PMID:17266109 NCBI chr 8:1,548,145...2,045,874
Ensembl chr 8:1,548,146...2,045,817
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression ISO Phencyclidine results in decreased expression of GRIN1 mRNA CTD PMID:17266109 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases expression ISO Phencyclidine results in decreased expression of GRIN2A mRNA; Phencyclidine results in decreased expression of GRIN2A protein CTD PMID:20659557 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP Phencyclidine results in increased expression of HMOX1 mRNA; Phencyclidine results in increased expression of HMOX1 protein
1,3-dimethylthiourea inhibits the reaction [Phencyclidine results in increased expression of HMOX1 protein]
CTD PMID:9875361 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hoxb9 homeo box B9 decreases expression ISO Phencyclidine results in decreased expression of HOXB9 mRNA CTD PMID:12105081 NCBI chr10:84,119,772...84,124,963
Ensembl chr10:84,119,884...84,123,390
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
decreases activity
EXP [Phencyclidine co-treated with Haloperidol] affects the activity of HTR2A protein; Clozapine promotes the reaction [Phencyclidine results in decreased activity of HTR2A protein] CTD PMID:15380371 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Phencyclidine co-treated with Dextroamphetamine] results in increased expression of JUND protein CTD PMID:16678866 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Kcnh1 potassium voltage-gated channel subfamily H member 1 decreases expression ISO Phencyclidine results in decreased expression of KCNH1 mRNA CTD PMID:12105081 NCBI chr13:110,920,712...111,232,291
Ensembl chr13:110,920,737...111,232,269
JBrowse link
G Kcnip3 potassium voltage-gated channel interacting protein 3 increases expression ISO Phencyclidine results in increased expression of KCNIP3 mRNA CTD PMID:17266109 NCBI chr 3:120,023,062...120,087,650
Ensembl chr 3:120,023,917...120,087,136
JBrowse link
G Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 increases expression ISO Phencyclidine results in increased expression of KCNJ4 mRNA CTD PMID:17266109 NCBI chr 7:120,717,378...120,744,602
Ensembl chr 7:120,717,375...120,744,602
JBrowse link
G Kitlg KIT ligand increases expression ISO Phencyclidine results in increased expression of KITL mRNA CTD PMID:12105081 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054
JBrowse link
G Lep leptin increases expression ISO Phencyclidine results in increased expression of LEP mRNA CTD PMID:12105081 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G LOC100911804 apolipoprotein L3-like increases expression ISO Phencyclidine results in increased expression of APOL2 mRNA CTD PMID:17205118 NCBI chr 7:118,979,230...118,986,699
Ensembl chr 7:118,979,608...118,983,984
JBrowse link
G Lpl lipoprotein lipase increases expression ISO Phencyclidine results in increased expression of LPL mRNA CTD PMID:17266109 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Mal mal, T-cell differentiation protein decreases expression ISO Phencyclidine results in decreased expression of MAL mRNA CTD PMID:17266109 NCBI chr 3:120,209,647...120,233,655
Ensembl chr 3:120,209,647...120,233,655
JBrowse link
G Maob monoamine oxidase B increases expression ISO Phencyclidine results in increased expression of MAOB mRNA CTD PMID:17266109 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 increases expression ISO Phencyclidine results in increased expression of MAPK8IP1 mRNA CTD PMID:17266109 NCBI chr 3:81,295,023...81,304,181
Ensembl chr 3:81,295,024...81,304,181
JBrowse link
G Mbp myelin basic protein increases expression ISO Phencyclidine results in increased expression of MBP mRNA CTD PMID:17266109 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mobp myelin-associated oligodendrocyte basic protein increases expression ISO Phencyclidine results in increased expression of MOBP mRNA CTD PMID:17266109 NCBI chr 8:128,824,420...128,854,492
Ensembl chr 8:128,824,508...128,850,358
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 affects localization
multiple interactions
ISO Phencyclidine affects the localization of NCF1 protein
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; ginsenoside Re inhibits the reaction [Phencyclidine affects the localization of NCF1 protein]; GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]
CTD PMID:29037473 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression ISO Phencyclidine results in increased expression of NR4A2 mRNA CTD PMID:17266109 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Ntsr1 neurotensin receptor 1 multiple interactions ISO NTSR1 gene affects the reaction [Phencyclidine results in decreased expression of DRD1 protein] CTD PMID:20659557 NCBI chr 3:175,982,313...176,046,345
Ensembl chr 3:175,885,894...176,046,345
JBrowse link
G P2ry1 purinergic receptor P2Y1 increases expression ISO Phencyclidine results in increased expression of P2RY1 mRNA CTD PMID:12105081 NCBI chr 2:151,314,818...151,320,312
Ensembl chr 2:151,314,818...151,320,319
JBrowse link
G Pde10a phosphodiesterase 10A increases expression ISO Phencyclidine results in increased expression of PDE10A mRNA CTD PMID:17266109 NCBI chr 1:52,360,296...52,544,448
Ensembl chr 1:52,360,296...52,544,450
JBrowse link
G Plp1 proteolipid protein 1 increases expression ISO Phencyclidine results in increased expression of PLP1 mRNA CTD PMID:17266109 NCBI chr  X:107,494,326...107,511,355
Ensembl chr  X:107,496,072...107,511,348
JBrowse link
G Prkcd protein kinase C, delta increases expression ISO Phencyclidine results in increased expression of PRKCD mRNA CTD PMID:12105081 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkcg protein kinase C, gamma increases expression EXP Phencyclidine results in increased expression of PRKCG mRNA CTD PMID:11169168 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
JBrowse link
G Ptgds prostaglandin D2 synthase increases expression ISO Phencyclidine results in increased expression of PTGDS mRNA CTD PMID:17266109 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Ptprcap protein tyrosine phosphatase, receptor type, C-associated protein increases expression ISO Phencyclidine results in increased expression of PTPRCAP mRNA CTD PMID:12105081 NCBI chr 1:219,403,970...219,406,129
Ensembl chr 1:219,403,970...219,406,128
JBrowse link
G Pvalb parvalbumin multiple interactions
decreases expression
EXP Clozapine inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA]; Haloperidol inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA] CTD PMID:12589379 NCBI chr 7:119,428,657...119,443,674
Ensembl chr 7:119,429,019...119,441,487
JBrowse link
G Reln reelin decreases expression ISO Phencyclidine results in decreased expression of RELN mRNA CTD PMID:17266109 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
JBrowse link
G Rgs4 regulator of G-protein signaling 4 increases expression ISO Phencyclidine results in increased expression of RGS4 mRNA CTD PMID:17266109 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Rtn4 reticulon 4 increases expression ISO Phencyclidine results in increased expression of RTN4 mRNA CTD PMID:17266109 NCBI chr14:114,126,931...114,174,459
Ensembl chr14:114,126,943...114,174,458
JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression ISO Phencyclidine results in increased expression of SCARB1 mRNA CTD PMID:17205118 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Selplg selectin P ligand increases expression ISO Phencyclidine results in increased expression of SELPLG mRNA CTD PMID:12105081 NCBI chr12:48,577,905...48,579,196
Ensembl chr12:48,577,905...48,579,196
JBrowse link
G Sema3b semaphorin 3B decreases expression ISO Phencyclidine results in decreased expression of SEMA3B mRNA CTD PMID:17205118 NCBI chr 8:116,353,791...116,362,655
Ensembl chr 8:116,354,073...116,361,343
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Phencyclidine results in increased expression of SGK1 mRNA CTD PMID:17266109 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Slc17a6 solute carrier family 17 member 6 increases expression ISO Phencyclidine results in increased expression of SLC17A6 mRNA CTD PMID:17266109 NCBI chr 1:106,980,463...107,038,717
Ensembl chr 1:106,998,623...107,038,704
JBrowse link
G Smad5 SMAD family member 5 decreases expression ISO Phencyclidine results in decreased expression of SMAD5 mRNA CTD PMID:12105081 NCBI chr17:8,307,448...8,336,996
Ensembl chr17:8,311,796...8,331,032
JBrowse link
G Sod1 superoxide dismutase 1 increases activity
multiple interactions
ISO Phencyclidine results in increased activity of SOD1 protein
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]; GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]
CTD PMID:29037473 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 decreases activity
multiple interactions
ISO Phencyclidine results in decreased activity of SOD2 protein
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]; GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]
CTD PMID:29037473 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases expression EXP Phencyclidine results in increased expression of SRC mRNA CTD PMID:11249956 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Srf serum response factor multiple interactions EXP [Dextroamphetamine co-treated with Phencyclidine] promotes the reaction [SRF protein binds to FOS promoter]; Phencyclidine promotes the reaction [SRF protein binds to FOS promoter] CTD PMID:12510024 NCBI chr 9:16,737,637...16,747,226
Ensembl chr 9:16,737,642...16,747,225
JBrowse link
G Syn2 synapsin II decreases expression ISO Phencyclidine results in decreased expression of SYN2 mRNA CTD PMID:17266109 NCBI chr 4:147,037,179...147,195,096
Ensembl chr 4:147,037,179...147,195,096
JBrowse link
G Syt2 synaptotagmin 2 increases expression ISO Phencyclidine results in increased expression of SYT2 mRNA CTD PMID:17266109 NCBI chr13:51,569,248...51,577,824
Ensembl chr13:51,534,025...51,578,052
JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression ISO Phencyclidine results in decreased expression of TAC1 mRNA CTD PMID:17266109 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tead4 TEA domain transcription factor 4 decreases expression ISO Phencyclidine results in decreased expression of TEAD4 mRNA CTD PMID:12105081 NCBI chr 4:161,542,566...161,619,848
Ensembl chr 4:161,540,130...161,587,222
JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases expression
ISO Phencyclidine inhibits the reaction [Methamphetamine results in decreased activity of TH protein]
Phencyclidine results in increased expression of TH mRNA
CTD PMID:1381816, PMID:12105081 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression
EXP Haloperidol affects the reaction [Phencyclidine affects the expression of TNF mRNA] CTD PMID:16478754 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ttr transthyretin decreases expression ISO Phencyclidine results in decreased expression of TTR mRNA CTD PMID:17266109 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta decreases expression ISO Phencyclidine results in decreased expression of YWHAB mRNA CTD PMID:17266109 NCBI chr 3:160,391,108...160,399,931
Ensembl chr 3:160,391,106...160,399,931
JBrowse link
G Zrsr1 zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1 decreases expression ISO Phencyclidine results in decreased expression of ZRSR1 mRNA CTD PMID:12105081 NCBI chr14:107,750,162...107,751,895
Ensembl chr14:107,750,162...107,751,892
JBrowse link
piperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il2 interleukin 2 decreases expression ISO piperazine analog results in decreased expression of IL2 mRNA CTD PMID:11859000 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
piperidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO piperidine analog inhibits the reaction [ACHE protein promotes the reaction [APP protein binds to APP protein]]
piperidine analog results in decreased activity of ACHE protein
CTD PMID:17681794 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO piperidine analog inhibits the reaction [ACHE protein promotes the reaction [APP protein binds to APP protein]]; piperidine analog inhibits the reaction [APP protein binds to APP protein] CTD PMID:17681794 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO piperidine analog results in decreased activity of BCHE protein CTD PMID:17681794 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO piperidine inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein] CTD PMID:17706638 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO piperidine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein] CTD PMID:17706638 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ifng interferon gamma multiple interactions ISO piperidine inhibits the reaction [Cadmium Chloride results in decreased secretion of IFNG protein] CTD PMID:17706638 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il2 interleukin 2 decreases expression
multiple interactions
ISO piperidine analog results in decreased expression of IL2 mRNA
piperidine inhibits the reaction [Cadmium Chloride results in decreased secretion of IL2 protein]
CTD PMID:11859000, PMID:17706638 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases activity ISO
EXP
piperidine analog results in decreased activity of SRD5A1 protein CTD PMID:10896124 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases activity ISO
EXP
piperidine analog results in decreased activity of SRD5A2 protein CTD PMID:10896124 NCBI chr 6:25,279,635...25,315,501
Ensembl chr 6:25,279,626...25,315,511
JBrowse link
pizotifen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Pizotyline results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
pyrrolidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hrh3 histamine receptor H3 multiple interactions EXP
ISO
pyrrolidine binds to and results in decreased activity of HRH3 protein CTD PMID:17169555 NCBI chr 3:175,474,310...175,479,395
Ensembl chr 3:175,473,078...175,479,395
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO [pyrrolidine analog binds to Palladium binds to Diclofenac] which results in decreased activity of PON1 protein; [pyrrolidine analog binds to Palladium binds to Mefenamic Acid] which results in decreased activity of PON1 protein; [pyrrolidine analog binds to Platinum binds to Diclofenac] which results in decreased activity of PON1 protein; [pyrrolidine analog binds to Platinum binds to Mefenamic Acid] which results in decreased activity of PON1 protein CTD PMID:29512227 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      atom 19782
        nonmetal atom 19657
          nitrogen atom 18539
            nitrogen molecular entity 18539
              organonitrogen compound 18309
                organonitrogen heterocyclic compound 17460
                  azacycloalkane 126
                    1,3,5,7-tetrazocane 0
                    1,4,7,10-tetraazacyclododecane + 0
                    1,4,7-triazonane 0
                    1,4,8,11-tetraazacyclotetradecane + 0
                    azepane 0
                    azetidine + 17
                    aziridine + 0
                    aziridinium 0
                    azocane + 9
                    dihydromotuporamine C 0
                    imidazolidine + 0
                    piperazine 1
                    piperidine + 100
                    plerixafor 0
                    pyrazolidine 0
                    pyrrolidine + 2
                    triazinane + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteromonocyclic compound 16444
                                    azacycloalkane 126
                                      1,3,5,7-tetrazocane 0
                                      1,4,7,10-tetraazacyclododecane + 0
                                      1,4,7-triazonane 0
                                      1,4,8,11-tetraazacyclotetradecane + 0
                                      azepane 0
                                      azetidine + 17
                                      aziridine + 0
                                      aziridinium 0
                                      azocane + 9
                                      dihydromotuporamine C 0
                                      imidazolidine + 0
                                      piperazine 1
                                      piperidine + 100
                                      plerixafor 0
                                      pyrazolidine 0
                                      pyrrolidine + 2
                                      triazinane + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.