|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
Benzothiazoles metabolite results in increased expression of BAX mRNA |
CTD |
PMID:23339777 |
|
NCBI chr 1:105,076,472...105,081,906
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
Benzothiazoles metabolite results in decreased expression of BCL2 mRNA |
CTD |
PMID:23339777 |
|
NCBI chr13:23,204,464...23,366,900
|
|
G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
Benzothiazoles metabolite results in decreased expression of BCL2L1 mRNA |
CTD |
PMID:23339777 |
|
NCBI chr 3:161,713,777...161,764,844
|
|
|
G |
Akr1b1 |
aldo-keto reductase family 1 member B1 |
decreases activity multiple interactions |
ISO |
zopolrestat results in decreased activity of AKR1B1 protein [zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased abundance of Reactive Oxygen Species]; [zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased secretion of Dinoprostone]; [zopolrestat results in decreased activity of AKR1B1 protein] which results in decreased susceptibility to Antigens, Plant |
CTD |
PMID:21334316 |
|
NCBI chr 4:63,899,222...63,913,315
|
|
G |
Akr1b10 |
aldo-keto reductase family 1 member B10 |
multiple interactions decreases activity |
ISO |
zopolrestat inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; zopolrestat inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde] zopolrestat results in decreased activity of AKR1B10 protein; zopolrestat results in decreased activity of AKR1B10 protein mutant form |
CTD |
PMID:18325492 PMID:19028477 |
|
NCBI chr 4:64,005,632...64,027,860
|
|
G |
Ccl4 |
C-C motif chemokine ligand 4 |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of CCL4 mRNA] |
CTD |
PMID:21334316 |
|
NCBI chr10:68,963,893...68,965,728
|
|
G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of CCL5 mRNA] |
CTD |
PMID:21334316 |
|
NCBI chr10:68,820,330...68,824,906
|
|
G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL10 mRNA] |
CTD |
PMID:21334316 |
|
NCBI chr13:45,024,921...45,029,586
|
|
G |
Il13 |
interleukin 13 |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL13 mRNA] |
CTD |
PMID:21334316 |
|
NCBI chr10:38,290,926...38,293,483
|
|
G |
Il18 |
interleukin 18 |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL18 mRNA] |
CTD |
PMID:21334316 |
|
NCBI chr 8:59,802,072...59,829,275
|
|
G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL4 mRNA] |
CTD |
PMID:21334316 |
|
NCBI chr10:38,272,003...38,277,549
|
|
G |
Il5 |
interleukin 5 |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL5 mRNA] |
CTD |
PMID:21334316 |
|
NCBI chr10:38,375,132...38,378,003
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL6 mRNA] zopolrestat inhibits the reaction [Antigens, Plant results in increased secretion of IL6 protein] |
CTD |
PMID:21334316 |
|
NCBI chr 4:5,889,999...5,894,575
|
|
G |
Jak2 |
Janus kinase 2 |
multiple interactions |
EXP |
zopolrestat results in decreased phosphorylation of and results in decreased activity of JAK2 protein |
CTD |
PMID:15746188 |
|
NCBI chr 1:236,408,905...236,468,769
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; zopolrestat inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] |
CTD |
PMID:24021941 |
|
NCBI chr10:64,313,335...64,349,221
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]; zopolrestat inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein] |
CTD |
PMID:24021941 |
|
NCBI chr13:64,714,063...64,722,320
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]; zopolrestat inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein] |
CTD |
PMID:24021941 |
|
NCBI chr 1:212,354,336...212,364,815
|
|
G |
Stat5a |
signal transducer and activator of transcription 5A |
multiple interactions |
EXP |
zopolrestat results in decreased phosphorylation of and results in decreased activity of STAT5A protein |
CTD |
PMID:15746188 |
|
NCBI chr10:86,285,859...86,310,187
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of TNF mRNA]; zopolrestat inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein] |
CTD |
PMID:21334316 PMID:24021941 |
|
NCBI chr20:3,626,685...3,629,303
|
|
|
G |
Ahr |
aryl hydrocarbon receptor |
increases expression |
ISO |
captax results in increased expression of AHR mRNA |
CTD |
PMID:21590714 |
|
NCBI chr 6:57,961,423...57,998,901
|
|
G |
Akr1c2 |
aldo-keto reductase family 1, member C2 |
increases activity increases expression |
ISO |
captax results in increased activity of AKR1C2 promoter captax results in increased expression of AKR1C2 mRNA |
CTD |
PMID:20491607 PMID:20713136 PMID:21195160 |
|
NCBI chr17:70,669,684...70,717,935
|
|
G |
Ampd3 |
adenosine monophosphate deaminase 3 |
increases expression |
ISO |
captax results in increased expression of AMPD3 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr 1:164,884,823...164,929,899
|
|
G |
Atf3 |
activating transcription factor 3 |
increases expression |
ISO |
captax results in increased expression of ATF3 mRNA |
CTD |
PMID:23999411 |
|
NCBI chr13:105,274,103...105,331,653
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
decreases expression |
ISO |
captax results in decreased expression of CCL2 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr10:67,503,077...67,504,875
|
|
G |
Ccl4 |
C-C motif chemokine ligand 4 |
increases secretion |
ISO |
captax results in increased secretion of CCL4 protein |
CTD |
PMID:16314067 |
|
NCBI chr10:68,963,893...68,965,728
|
|
G |
Ccr2 |
C-C motif chemokine receptor 2 |
increases expression |
ISO |
captax results in increased expression of CCR2 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr 8:132,611,883...132,619,106
|
|
G |
Ccr5 |
C-C motif chemokine receptor 5 |
increases expression |
ISO |
captax results in increased expression of CCR5 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr 8:132,629,097...132,660,980
|
|
G |
Cd86 |
CD86 molecule |
increases expression |
ISO |
captax results in increased expression of CD86 protein |
CTD |
PMID:12423654 |
|
NCBI chr11:77,647,565...77,706,178
|
|
G |
Creb1 |
cAMP responsive element binding protein 1 |
decreases expression |
ISO |
captax results in decreased expression of CREB1 mRNA |
CTD |
PMID:20385217 |
|
NCBI chr 9:73,397,333...73,466,339
|
|
G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
increases expression |
ISO |
captax results in increased expression of CXCL1 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr14:17,477,542...17,479,321
|
|
G |
Cxcl14 |
C-X-C motif chemokine ligand 14 |
decreases expression |
ISO |
captax results in decreased expression of CXCL14 mRNA; captax results in decreased expression of CXCL14 protein |
CTD |
PMID:31734321 |
|
NCBI chr17:8,323,150...8,331,176
|
|
G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
increases expression |
ISO |
captax results in increased expression of CXCL2 protein |
CTD |
PMID:23178550 |
|
NCBI chr14:17,465,210...17,467,255
|
|
G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
increases expression |
ISO |
captax results in increased expression of CXCL1 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr14:17,571,900...17,573,624
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
ISO |
captax results in increased expression of CYP1A1 mRNA |
CTD |
PMID:20491607 |
|
NCBI chr 8:66,991,940...66,998,014
|
|
G |
Dio1 |
iodothyronine deiodinase 1 |
decreases activity |
ISO |
captax results in decreased activity of DIO1 protein |
CTD |
PMID:29228274 |
|
NCBI chr 5:122,074,285...122,090,983
|
|
G |
Dnajb4 |
DnaJ heat shock protein family (Hsp40) member B4 |
increases expression |
ISO |
captax results in increased expression of DNAJB4 mRNA |
CTD |
PMID:23999411 PMID:27965148 |
|
NCBI chr 2:243,790,296...243,819,042
|
|
G |
Enpp2 |
ectonucleotide pyrophosphatase/phosphodiesterase 2 |
increases expression |
ISO |
captax results in increased expression of ENPP2 protein |
CTD |
PMID:22952646 |
|
NCBI chr 7:88,092,140...88,214,758
|
|
G |
F3 |
coagulation factor III, tissue factor |
increases expression |
ISO |
captax results in increased expression of F3 protein |
CTD |
PMID:25569083 |
|
NCBI chr 2:212,511,675...212,523,375
|
|
G |
Fth1 |
ferritin heavy chain 1 |
increases expression |
ISO |
captax results in increased expression of FTH1 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr 1:216,052,037...216,054,325
|
|
G |
Ftl1 |
ferritin light chain 1 |
increases expression |
ISO |
captax results in increased expression of FTL mRNA |
CTD |
PMID:24211530 |
|
NCBI chr 1:105,072,858...105,074,705
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression |
ISO |
captax results in increased expression of GCLC mRNA |
CTD |
PMID:20491607 |
|
NCBI chr 8:87,510,251...87,548,896
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
captax results in increased expression of GCLM mRNA |
CTD |
PMID:23999411 PMID:24211530 |
|
NCBI chr 2:213,032,135...213,052,192
|
|
G |
H2ax |
H2A.X variant histone |
increases expression multiple interactions |
ISO |
captax results in increased expression of H2AX protein 1-aminobenzotriazole inhibits the reaction [captax results in increased expression of H2AX protein]; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [captax results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [captax results in increased expression of H2AX protein]; Disulfiram inhibits the reaction [captax results in increased expression of H2AX protein] |
CTD |
PMID:35279910 |
|
NCBI chr 8:53,568,718...53,570,072
|
|
G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
captax results in increased expression of HMOX1 mRNA |
CTD |
PMID:20713136 PMID:23445166 PMID:24211530 |
|
NCBI chr19:13,452,365...13,479,823
|
|
G |
Hspa6l-ps1 |
heat shock protein family A (Hsp70) member 6 like, pseudogene 1 |
increases expression |
ISO |
captax results in increased expression of HSPA6 mRNA |
CTD |
PMID:23999411 |
|
NCBI chr13:85,805,911...85,807,052
|
|
G |
Ifng |
interferon gamma |
increases secretion |
ISO |
captax results in increased secretion of IFNG protein |
CTD |
PMID:22245253 |
|
NCBI chr 7:55,789,180...55,793,216
|
|
G |
Il18 |
interleukin 18 |
increases expression |
ISO |
captax results in increased expression of IL18 protein |
CTD |
PMID:23063874 |
|
NCBI chr 8:59,802,072...59,829,275
|
|
G |
Il1a |
interleukin 1 alpha |
increases expression |
ISO |
captax results in increased expression of IL1A protein captax results in increased expression of IL1A mRNA |
CTD |
PMID:23178550 PMID:33715048 |
|
NCBI chr 3:136,979,804...136,990,236
|
|
G |
Il1b |
interleukin 1 beta |
increases expression increases secretion |
ISO |
captax results in increased expression of IL1B mRNA captax results in increased secretion of IL1B protein |
CTD |
PMID:33715048 |
|
NCBI chr 3:137,030,200...137,036,581
|
|
G |
Il2 |
interleukin 2 |
increases secretion |
ISO |
captax results in increased secretion of IL2 protein |
CTD |
PMID:22245253 |
|
NCBI chr 2:121,932,968...121,937,672
|
|
G |
Il6 |
interleukin 6 |
increases secretion |
ISO |
captax results in increased secretion of IL6 protein |
CTD |
PMID:22245253 |
|
NCBI chr 4:5,889,999...5,894,575
|
|
G |
Il7r |
interleukin 7 receptor |
increases expression |
ISO |
captax results in increased expression of IL7R mRNA |
CTD |
PMID:20713136 |
|
NCBI chr 2:58,452,393...58,477,757
|
|
G |
Mir146a |
microRNA 146a |
increases expression |
ISO |
captax results in increased expression of MIR146A mRNA |
CTD |
PMID:37326882 |
|
NCBI chr10:28,349,996...28,350,090
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
increases expression |
ISO |
captax results in increased expression of MMP9 mRNA; captax results in increased expression of MMP9 protein |
CTD |
PMID:22952646 |
|
NCBI chr 3:174,103,474...174,111,434
|
|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
increases expression |
ISO |
captax results in increased expression of MYC mRNA |
CTD |
PMID:24211530 |
|
NCBI chr 7:95,483,105...95,488,031
|
|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
affects expression |
ISO |
captax affects the expression of NFKB1 mRNA |
CTD |
PMID:20385217 |
|
NCBI chr 2:226,689,745...226,805,897
|
|
G |
Notch3 |
notch receptor 3 |
decreases expression |
ISO |
captax results in decreased expression of NOTCH3 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr 7:11,132,984...11,184,025
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
ISO |
captax results in increased expression of NQO1 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr19:52,205,374...52,220,267
|
|
G |
Pmaip1 |
phorbol-12-myristate-13-acetate-induced protein 1 |
increases expression |
ISO |
captax results in increased expression of PMAIP1 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr18:62,255,970...62,262,384
|
|
G |
Rgs1 |
regulator of G-protein signaling 1 |
increases expression |
ISO |
captax results in increased expression of RGS1 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr13:58,568,844...58,573,187
|
|
G |
Sel1l3 |
SEL1L family member 3 |
increases expression |
ISO |
captax results in increased expression of SEL1L3 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr14:57,775,515...57,882,076
|
|
G |
Slc5a5 |
solute carrier family 5 member 5 |
multiple interactions |
ISO |
captax inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] |
CTD |
PMID:27979590 |
|
NCBI chr16:18,546,709...18,556,698
|
|
G |
Slc7a11 |
solute carrier family 7 member 11 |
increases expression |
ISO |
captax results in increased expression of SLC7A11 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr 2:136,532,912...136,668,560
|
|
G |
Sqstm1 |
sequestosome 1 |
increases expression |
ISO |
captax results in increased expression of SQSTM1 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr10:35,026,598...35,037,750
|
|
G |
Syne2 |
spectrin repeat containing nuclear envelope protein 2 |
decreases expression |
ISO |
captax results in decreased expression of SYNE2 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr 6:100,272,729...100,586,364
|
|
G |
Tnf |
tumor necrosis factor |
decreases expression |
ISO |
captax results in decreased expression of TNF mRNA |
CTD |
PMID:20385217 |
|
NCBI chr20:3,626,685...3,629,303
|
|
G |
Tnnt2 |
troponin T2, cardiac type |
decreases expression |
ISO |
captax results in decreased expression of TNNT2 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr13:49,819,123...49,837,125
|
|
G |
Tpo |
thyroid peroxidase |
multiple interactions decreases activity |
ISO EXP |
captax binds to and results in decreased activity of TPO protein captax results in decreased activity of TPO protein |
CTD |
PMID:23959146 PMID:26865668 PMID:26884060 PMID:31629072 |
|
NCBI chr 6:52,425,998...52,495,793
|
|
G |
Txnrd1 |
thioredoxin reductase 1 |
increases expression |
ISO |
captax results in increased expression of TXNRD1 mRNA |
CTD |
PMID:23445166 PMID:24211530 |
|
NCBI chr 7:22,717,620...22,802,553
|
|
G |
Vegfa |
vascular endothelial growth factor A |
increases expression |
ISO |
captax results in increased expression of VEGFA protein |
CTD |
PMID:25617811 |
|
NCBI chr 9:22,452,854...22,468,194
|
|
|
G |
Ahr |
aryl hydrocarbon receptor |
affects binding |
ISO |
benzothiazole binds to AHR protein; benzothiazole metabolite binds to AHR protein |
CTD |
PMID:16705413 |
|
NCBI chr 6:57,961,423...57,998,901
|
|
G |
Ephx1 |
epoxide hydrolase 1 |
increases expression |
EXP |
benzothiazole results in increased expression of EPHX1 mRNA |
CTD |
PMID:8951341 |
|
NCBI chr13:95,246,079...95,275,852
|
|
G |
Gsta2 |
glutathione S-transferase alpha 2 |
increases expression |
EXP |
benzothiazole results in increased expression of GSTA2 mRNA |
CTD |
PMID:8951341 |
|
NCBI chr 8:79,184,535...79,196,827
|
|
G |
Gstm1 |
glutathione S-transferase mu 1 |
increases expression |
EXP |
benzothiazole results in increased expression of GSTM1 mRNA |
CTD |
PMID:8951341 |
|
NCBI chr 2:198,338,005...198,346,007
|
|
G |
Gstm2 |
glutathione S-transferase mu 2 |
increases expression |
EXP |
benzothiazole results in increased expression of GSTM2 mRNA |
CTD |
PMID:8951341 |
|
NCBI chr 2:195,624,015...195,628,774
|
|
|
G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
Dithiazanine results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
|
NCBI chr 4:11,719,357...11,751,424
|
|
|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
[dibenzothiazyl disulfide co-treated with Sodium Dodecyl Sulfate] results in increased expression of IFNG protein |
CTD |
PMID:12062936 |
|
NCBI chr 7:55,789,180...55,793,216
|
|
G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
[dibenzothiazyl disulfide co-treated with Sodium Dodecyl Sulfate] results in increased expression of IL4 protein |
CTD |
PMID:12062936 |
|
NCBI chr10:38,272,003...38,277,549
|
|
|
G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
Dithiazanine results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
|
NCBI chr 4:11,719,357...11,751,424
|
|
|
G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
ISO |
[SLCO1B1 protein co-treated with ABCC2 protein] results in increased transport of E 3040 analog |
CTD |
PMID:19628752 |
|
NCBI chr 1:252,613,875...252,672,459
|
|
G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
affects export |
ISO |
ABCG2 protein affects the export of E 3040 analog |
CTD |
PMID:15598971 |
|
NCBI chr 4:89,006,056...89,132,915
|
|
G |
Slc22a12 |
solute carrier family 22 member 12 |
multiple interactions |
ISO |
E 3040 inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] |
CTD |
PMID:21272127 |
|
NCBI chr 1:203,845,039...203,852,496
|
|
|
G |
Car1 |
carbonic anhydrase 1 |
multiple interactions |
ISO |
Ethoxzolamide binds to and results in decreased activity of CA1 protein |
CTD |
PMID:17826101 |
|
NCBI chr 2:88,550,681...88,593,454
|
|
G |
Car2 |
carbonic anhydrase 2 |
multiple interactions |
ISO |
Ethoxzolamide binds to and results in decreased activity of CA2 protein |
CTD |
PMID:17826101 |
|
NCBI chr 2:88,462,883...88,478,012
|
|
G |
Car3 |
carbonic anhydrase 3 |
multiple interactions |
ISO |
Ethoxzolamide binds to and results in decreased activity of CA3 protein |
CTD |
PMID:17826101 |
|
NCBI chr 2:88,491,666...88,501,299
|
|
|
G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
multiple interactions |
ISO |
lubeluzole binds to and results in decreased activity of KCNH2 protein |
CTD |
PMID:29550817 |
|
NCBI chr 4:11,719,357...11,751,424
|
|
|
G |
Ar |
androgen receptor |
multiple interactions |
ISO |
Dihydrotestosterone inhibits the reaction [mefenacet results in increased activity of AR protein] |
CTD |
PMID:15064155 |
|
NCBI chr X:63,104,771...63,273,934
|
|
G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
multiple interactions |
ISO |
CYP2B6 protein results in increased metabolism of and results in decreased susceptibility to mefenacet |
CTD |
PMID:15853388 |
|
NCBI chr 1:90,780,468...90,859,852
|
|
G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
mefenacet binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:21115097 |
|
NCBI chr11:75,965,717...76,006,733
|
|
|
G |
Ache |
acetylcholinesterase |
multiple interactions |
EXP |
Pramipexole inhibits the reaction [amyloid beta-protein (1-42) results in increased activity of ACHE protein] |
CTD |
PMID:35868426 |
|
NCBI chr12:25,042,882...25,050,608
|
|
G |
Atp5f1a |
ATP synthase F1 subunit alpha |
multiple interactions |
EXP |
Pramipexole inhibits the reaction [amyloid beta-protein (1-42) results in decreased expression of ATP5F1A protein] |
CTD |
PMID:35868426 |
|
NCBI chr18:73,567,537...73,575,473
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
pramipexole inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein] |
CTD |
PMID:16362428 |
|
NCBI chr16:52,395,539...52,413,794
|
|
G |
Drd2 |
dopamine receptor D2 |
multiple interactions |
EXP ISO |
pramipexole binds to and results in increased activity of DRD2 protein |
CTD |
PMID:10728880 |
|
NCBI chr 8:58,605,403...58,669,339
|
|
G |
Drd3 |
dopamine receptor D3 |
multiple interactions |
ISO |
pramipexole binds to and results in increased activity of DRD3 protein |
CTD |
PMID:10728880 |
|
NCBI chr11:70,385,586...70,437,793
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
pramipexole inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:16362428 |
|
NCBI chr16:8,645,171...8,728,225
|
|
G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
EXP |
pramipexole inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:16362428 |
|
NCBI chr10:34,670,750...34,711,972
|
|
G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
EXP |
Pramipexole results in increased expression of PPARGC1A protein |
CTD |
PMID:35868426 |
|
NCBI chr14:63,073,505...63,729,215
|
|
G |
Ptprd |
protein tyrosine phosphatase, receptor type, D |
increases expression |
EXP |
[Pramipexole cotreated with exercise] increases expression of Ptprd protein in the striatum |
RGD |
PMID:37633178 |
RGD:401976430 |
NCBI chr 5:90,046,993...90,698,977 NCBI chr 5:91,122,354...91,641,754
|
|
G |
Sdhb |
succinate dehydrogenase complex iron sulfur subunit B |
multiple interactions |
EXP |
Pramipexole inhibits the reaction [amyloid beta-protein (1-42) results in decreased expression of SDHB protein] |
CTD |
PMID:35868426 |
|
NCBI chr 5:158,547,775...158,568,589
|
|
|
G |
Ar |
androgen receptor |
multiple interactions |
ISO |
Chloroquine inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein alternative form]; Chloroquine inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein]; Riluzole promotes the reaction [AR protein binds to SQSTM1 protein]; Riluzole results in increased degradation of and results in decreased expression of AR protein; Riluzole results in increased degradation of and results in decreased expression of AR protein alternative form; Riluzole results in increased degradation of and results in decreased expression of AR protein mutant form; STF 083010 inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein] |
CTD |
PMID:30280407 |
|
NCBI chr X:63,104,771...63,273,934
|
|
G |
Atf6 |
activating transcription factor 6 |
increases expression |
ISO |
Riluzole results in increased expression of ATF6 protein |
CTD |
PMID:30280407 |
|
NCBI chr13:85,460,312...85,639,959
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression |
EXP |
Riluzole results in increased expression of BCL2 protein |
CTD |
PMID:20885006 |
|
NCBI chr13:23,204,464...23,366,900
|
|
G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO |
Palmitic Acid promotes the reaction [Riluzole results in increased activity of CASP3 protein] |
CTD |
PMID:19528481 PMID:22700542 |
|
NCBI chr16:52,395,539...52,413,794
|
|
G |
Casp4 |
caspase 4 |
increases activity |
ISO |
Riluzole results in increased activity of CASP4 protein |
CTD |
PMID:19528481 |
|
NCBI chr 8:10,883,817...10,919,978
|
|
G |
Casp7 |
caspase 7 |
multiple interactions increases activity |
ISO |
Palmitic Acid promotes the reaction [Riluzole results in increased activity of CASP7 protein] |
CTD |
PMID:22700542 |
|
NCBI chr 1:265,442,647...265,481,938
|
|
G |
Casp8 |
caspase 8 |
increases activity |
ISO |
Riluzole results in increased activity of CASP8 protein |
CTD |
PMID:19528481 |
|
NCBI chr 9:67,747,109...67,806,699
|
|
G |
Casp9 |
caspase 9 |
increases activity |
ISO |
Riluzole results in increased activity of CASP9 protein |
CTD |
PMID:19528481 |
|
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity |
ISO |
Riluzole results in decreased activity of CYP1A1 protein |
CTD |
PMID:33814510 |
|
NCBI chr 8:66,991,940...66,998,014
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
Riluzole results in decreased activity of CYP1B1 protein |
CTD |
PMID:33814510 |
|
NCBI chr 6:21,093,927...21,103,091
|
|
G |
Glul |
glutamate-ammonia ligase |
multiple interactions |
EXP |
Riluzole inhibits the reaction [manganese chloride results in decreased expression of and results in decreased activity of GLUL protein]; Riluzole inhibits the reaction [manganese chloride results in decreased expression of GLUL mRNA] |
CTD |
PMID:19615351 |
|
NCBI chr13:68,519,500...68,585,554
|
|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
ISO |
Riluzole results in increased expression of HSPA5 protein |
CTD |
PMID:30280407 |
|
NCBI chr 3:38,453,016...38,457,475
|
|
G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Riluzole |
CTD |
PMID:19362101 |
|
NCBI chr 3:136,979,804...136,990,236
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Riluzole |
CTD |
PMID:19362101 |
|
NCBI chr 4:5,889,999...5,894,575
|
|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
decreases phosphorylation |
EXP |
Riluzole results in decreased phosphorylation of JUN protein |
CTD |
PMID:10067977 |
|
NCBI chr 5:115,009,900...115,012,993
|
|
G |
Klk1c10 |
kallikrein 1-related peptidase C10 |
decreases expression |
ISO |
Riluzole results in decreased expression of KLK3 mRNA |
CTD |
PMID:30280407 |
|
NCBI chr 1:94,402,993...94,407,052
|
|
G |
Nefh |
neurofilament heavy chain |
decreases phosphorylation |
EXP |
Riluzole results in decreased phosphorylation of NEFH protein |
CTD |
PMID:19429076 |
|
NCBI chr14:84,044,428...84,054,413
|
|
G |
Nefm |
neurofilament medium chain |
affects localization decreases phosphorylation |
EXP |
Riluzole affects the localization of NEFM protein Riluzole results in decreased phosphorylation of NEFM protein |
CTD |
PMID:19429076 |
|
NCBI chr15:46,535,857...46,541,161
|
|
G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity |
ISO |
Riluzole results in increased activity of NR1I2 protein |
CTD |
PMID:25455453 |
|
NCBI chr11:75,965,717...76,006,733
|
|
G |
Prkcb |
protein kinase C, beta |
multiple interactions |
ISO |
Riluzole inhibits the reaction [VEGFA protein results in increased phosphorylation of PRKCB protein] |
CTD |
PMID:16303979 |
|
NCBI chr 1:186,263,397...186,594,743
|
|
G |
Slc17a7 |
solute carrier family 17 member 7 |
decreases expression |
EXP |
Riluzole results in decreased expression of SLC17A7 protein |
CTD |
PMID:17507170 |
|
NCBI chr 1:95,649,709...95,661,591
|
|
G |
Slc1a2 |
solute carrier family 1 member 2 |
multiple interactions increases expression |
EXP |
Riluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 mRNA]; Riluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 protein]; Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of and results in decreased activity of SLC1A2 protein]; Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A2 mRNA] Riluzole results in increased expression of SLC1A2 mRNA; Riluzole results in increased expression of SLC1A2 protein |
CTD |
PMID:19615351 PMID:22966415 |
|
NCBI chr 3:109,460,109...109,590,445
|
|
G |
Slc1a3 |
solute carrier family 1 member 3 |
multiple interactions increases expression |
EXP |
Riluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A3 mRNA]; Riluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A3 protein]; Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of and results in decreased activity of SLC1A3 protein]; Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A3 mRNA] Riluzole results in increased expression of SLC1A3 mRNA; Riluzole results in increased expression of SLC1A3 protein |
CTD |
PMID:19615351 PMID:22966415 |
|
NCBI chr 2:57,755,495...57,830,605
|
|
G |
Sqstm1 |
sequestosome 1 |
multiple interactions |
ISO |
Riluzole promotes the reaction [AR protein binds to SQSTM1 protein] |
CTD |
PMID:30280407 |
|
NCBI chr10:35,026,598...35,037,750
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Riluzole |
CTD |
PMID:19362101 |
|
NCBI chr20:3,626,685...3,629,303
|
|
G |
Utrn |
utrophin |
increases expression |
ISO |
Riluzole results in increased expression of UTRN mRNA |
CTD |
PMID:22028826 |
|
NCBI chr 1:6,720,854...7,224,313
|
|
G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
Riluzole inhibits the reaction [VEGFA protein results in increased phosphorylation of PRKCB protein] |
CTD |
PMID:16303979 |
|
NCBI chr 9:22,452,854...22,468,194
|
|
G |
Xbp1 |
X-box binding protein 1 |
increases expression |
ISO |
Riluzole results in increased expression of XBP1 protein |
CTD |
PMID:30280407 |
|
NCBI chr14:84,604,623...84,609,707
|
|
|
G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
increases metabolic processing |
ISO |
CYP2D6 protein results in increased metabolism of sabeluzole |
CTD |
PMID:11259989 |
|
NCBI chr 7:115,762,662...115,771,832
|
|
|
G |
Afp |
alpha-fetoprotein |
increases expression |
ISO |
Saccharin results in increased expression of AFP mRNA |
CTD |
PMID:26272751 |
|
NCBI chr14:17,573,412...17,591,476
|
|
G |
Car13 |
carbonic anhydrase 13 |
increases expression |
ISO |
Saccharin results in increased expression of CAR13 mRNA |
CTD |
PMID:19000923 |
|
NCBI chr 2:86,928,401...86,959,525
|
|
G |
Car3 |
carbonic anhydrase 3 |
multiple interactions |
ISO |
Saccharin binds to and results in decreased activity of CA3 protein |
CTD |
PMID:17826101 |
|
NCBI chr 2:88,491,666...88,501,299
|
|
G |
Cdk1 |
cyclin-dependent kinase 1 |
increases expression |
ISO |
Saccharin results in increased expression of CDK1 mRNA |
CTD |
PMID:26272751 |
|
NCBI chr20:19,265,252...19,280,456
|
|
G |
Cer1 |
cerberus 1, DAN family BMP antagonist |
increases expression |
ISO |
Saccharin results in increased expression of CER1 mRNA |
CTD |
PMID:26272751 |
|
NCBI chr 5:102,352,364...102,355,720
|
|
G |
Chek1 |
checkpoint kinase 1 |
increases expression |
ISO |
Saccharin results in increased expression of CHEK1 mRNA |
CTD |
PMID:19000923 |
|
NCBI chr 8:44,609,417...44,629,867
|
|
G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
increases expression |
ISO |
Saccharin results in increased expression of FOSL1 mRNA |
CTD |
PMID:19000923 |
|
NCBI chr 1:212,183,885...212,192,391
|
|
G |
Gnat3 |
G protein subunit alpha transducin 3 |
affects response to substance |
ISO |
GNAT3 protein affects the susceptibility to Saccharin |
CTD |
PMID:16740645 |
|
NCBI chr 4:17,162,500...17,212,283
|
|
G |
Hdac7 |
histone deacetylase 7 |
decreases expression |
ISO |
Saccharin results in decreased expression of HDAC7 mRNA |
CTD |
PMID:26272751 |
|
NCBI chr 7:128,923,918...128,961,926
|
|
G |
Hells |
helicase, lymphoid specific |
increases expression |
ISO |
Saccharin results in increased expression of HELLS mRNA |
CTD |
PMID:19000923 |
|
NCBI chr 1:246,113,580...246,159,230
|
|
G |
Il1rl1 |
interleukin 1 receptor-like 1 |
increases expression |
ISO |
Saccharin results in increased expression of IL1RL1 mRNA |
CTD |
PMID:19000923 |
|
NCBI chr 9:42,661,694...42,727,266
|
|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
Saccharin results in increased expression of JUN mRNA |
CTD |
PMID:19000923 |
|
NCBI chr 5:115,009,900...115,012,993
|
|
G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
Saccharin results in increased expression of JUNB mRNA |
CTD |
PMID:19000923 |
|
NCBI chr19:23,176,265...23,178,049
|
|
G |
Kdr |
kinase insert domain receptor |
increases expression |
ISO |
Saccharin results in increased expression of KDR mRNA |
CTD |
PMID:26272751 |
|
NCBI chr14:32,572,031...32,615,204
|
|
G |
Mcm3 |
minichromosome maintenance complex component 3 |
increases expression |
ISO |
Saccharin results in increased expression of MCM3 mRNA |
CTD |
PMID:19000923 |
|
NCBI chr 9:30,715,602...30,733,746
|
|
G |
Mesp1 |
mesoderm posterior bHLH transcription factor 1 |
decreases expression |
ISO |
Saccharin results in decreased expression of MESP1 mRNA |
CTD |
PMID:26272751 |
|
NCBI chr 1:143,147,671...143,149,189
|
|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
increases expression |
ISO |
Saccharin results in increased expression of MYC mRNA |
CTD |
PMID:26272751 |
|
NCBI chr 7:95,483,105...95,488,031
|
|
G |
Myo1e |
myosin IE |
increases expression |
ISO |
Saccharin results in increased expression of MYO1E mRNA |
CTD |
PMID:26272751 |
|
NCBI chr 8:70,887,934...71,080,180
|
|
G |
Nes |
nestin |
increases expression |
ISO |
Saccharin results in increased expression of NES mRNA |
CTD |
PMID:26272751 |
|
NCBI chr 2:175,735,715...175,745,631
|
|
G |
Nos2 |
nitric oxide synthase 2 |
increases expression |
ISO |
Saccharin results in increased expression of NOS2 mRNA |
CTD |
PMID:28472674 |
|
NCBI chr10:64,313,335...64,349,221
|
|
G |
Nup54 |
nucleoporin 54 |
increases expression |
ISO |
Saccharin results in increased expression of NUP54 mRNA |
CTD |
PMID:19000923 |
|
NCBI chr14:15,617,630...15,636,029
|
|
G |
Orm1 |
orosomucoid 1 |
increases expression |
ISO |
Saccharin results in increased expression of ORM1 mRNA |
CTD |
PMID:19000923 |
|
NCBI chr 5:81,788,509...81,791,661
|
|
G |
Phex |
phosphate regulating endopeptidase X-linked |
increases expression |
ISO |
Saccharin results in increased expression of PHEX mRNA |
CTD |
PMID:19000923 |
|
NCBI chr X:41,422,561...41,671,226
|
|
G |
Pik3r5 |
phosphoinositide-3-kinase, regulatory subunit 5 |
increases expression |
ISO |
Saccharin results in increased expression of PIK3R5 mRNA |
CTD |
PMID:19000923 |
|
NCBI chr10:53,631,469...53,699,550
|
|
G |
Pnpla6 |
patatin-like phospholipase domain containing 6 |
decreases expression |
ISO |
Saccharin results in decreased expression of PNPLA6 mRNA |
CTD |
PMID:26272751 |
|
NCBI chr12:1,574,387...1,603,735
|
|
G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
[Saccharin co-treated with Glucose] binds to PPARA protein; Saccharin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] |
CTD |
PMID:18812576 |
|
NCBI chr 7:118,712,261...118,780,723
|
|
G |
Rad21 |
RAD21 cohesin complex component |
increases expression |
ISO |
Saccharin results in increased expression of RAD21 mRNA |
CTD |
PMID:19000923 |
|
NCBI chr 7:85,177,715...85,204,657
|
|
G |
Rif1 |
replication timing regulatory factor 1 |
increases expression |
ISO |
Saccharin results in increased expression of RIF1 mRNA |
CTD |
PMID:19000923 |
|
NCBI chr 3:56,963,840...57,017,106
|
|
G |
Scarb1 |
scavenger receptor class B, member 1 |
increases expression |
ISO |
Saccharin results in increased expression of SCARB1 mRNA |
CTD |
PMID:19000923 |
|
NCBI chr12:36,957,302...37,023,982
|
|
G |
Shh |
sonic hedgehog signaling molecule |
decreases expression |
ISO |
Saccharin results in decreased expression of SHH mRNA |
CTD |
PMID:26272751 |
|
NCBI chr 4:6,954,017...6,963,170
|
|
G |
Slc2a1 |
solute carrier family 2 member 1 |
increases expression |
ISO |
Saccharin results in increased expression of SLC2A1 mRNA |
CTD |
PMID:19000923 |
|
NCBI chr 5:138,002,522...138,030,742
|
|
G |
Stmn1 |
stathmin 1 |
increases expression |
ISO |
Saccharin results in increased expression of STMN1 mRNA |
CTD |
PMID:19000923 |
|
NCBI chr 5:151,964,308...151,970,843
|
|
G |
Tas1r3 |
taste 1 receptor member 3 |
affects response to substance multiple interactions |
ISO |
TAS1R3 protein affects the susceptibility to Saccharin TRPV1 protein affects the reaction [TAS1R3 protein affects the susceptibility to Saccharin] |
CTD |
PMID:18804451 |
|
NCBI chr 5:171,750,937...171,754,993
|
|
G |
Tas2r136 |
taste receptor, type 2, member 136 |
increases activity |
ISO |
Saccharin results in increased activity of TAS2R31 protein |
CTD |
PMID:21629661 |
|
NCBI chr 4:166,098,848...166,099,840
|
|
G |
Tfrc |
transferrin receptor |
increases expression |
ISO |
Saccharin results in increased expression of TFRC mRNA |
CTD |
PMID:19000923 |
|
NCBI chr11:81,668,478...81,690,318
|
|
G |
Tnf |
tumor necrosis factor |
increases expression |
ISO |
Saccharin results in increased expression of TNF mRNA |
CTD |
PMID:28472674 |
|
NCBI chr20:3,626,685...3,629,303
|
|
G |
Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
multiple interactions increases activity |
ISO |
TRPV1 protein affects the reaction [TAS1R3 protein affects the susceptibility to Saccharin] Saccharin results in increased activity of TRPV1 protein |
CTD |
PMID:17567713 PMID:18804451 |
|
NCBI chr10:58,349,936...58,375,021
|
|
G |
Vegfa |
vascular endothelial growth factor A |
increases expression |
ISO |
Saccharin results in increased expression of VEGFA mRNA |
CTD |
PMID:19000923 PMID:26272751 |
|
NCBI chr 9:22,452,854...22,468,194
|
|
G |
Wnt3 |
Wnt family member 3 |
increases expression |
ISO |
Saccharin results in increased expression of WNT3 mRNA |
CTD |
PMID:26272751 |
|
NCBI chr10:89,180,224...89,224,195
|
|
|
G |
Alb |
albumin |
multiple interactions affects binding |
EXP ISO |
ziprasidone results in decreased expression of and results in increased reduction of ALB protein ziprasidone binds to ALB protein [ziprasidone results in increased reduction of Cysteine] which results in increased activity of ALB protein; stearic acid inhibits the reaction [ziprasidone binds to ALB protein] |
CTD |
PMID:31400341 |
|
NCBI chr14:17,891,564...17,907,043
|
|
G |
Cat |
catalase |
increases expression |
EXP |
ziprasidone results in increased expression of CAT mRNA |
CTD |
PMID:32937854 |
|
NCBI chr 3:110,297,340...110,329,526
|
|
G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
increases expression |
ISO |
ziprasidone results in increased expression of HMGCR mRNA |
CTD |
PMID:17052361 |
|
NCBI chr 2:29,732,163...29,754,276
|
|
G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
increases expression |
ISO |
ziprasidone results in increased expression of HMGCS1 mRNA |
CTD |
PMID:17052361 |
|
NCBI chr 2:53,379,457...53,399,807
|
|
G |
Hmox1 |
heme oxygenase 1 |
increases expression |
EXP |
ziprasidone results in increased expression of HMOX1 mRNA |
CTD |
PMID:32937854 |
|
NCBI chr19:13,452,365...13,479,823
|
|
G |
Htr1a |
5-hydroxytryptamine receptor 1A |
multiple interactions |
EXP |
[N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein] which results in increased susceptibility to ziprasidone |
CTD |
PMID:15996562 |
|
NCBI chr 2:38,427,169...38,431,733
|
|
G |
Htr2a |
5-hydroxytryptamine receptor 2A |
multiple interactions |
ISO |
ziprasidone inhibits the reaction [Ketanserin binds to HTR2A protein] |
CTD |
PMID:16314884 |
|
NCBI chr15:56,360,647...56,428,703
|
|
G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
ziprasidone results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
|
NCBI chr 4:11,719,357...11,751,424
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
EXP |
ziprasidone results in increased expression of NQO1 mRNA |
CTD |
PMID:32937854 |
|
NCBI chr19:52,205,374...52,220,267
|
|
G |
Sc5d |
sterol-C5-desaturase |
increases expression |
ISO |
ziprasidone results in increased expression of SC5D mRNA |
CTD |
PMID:17052361 |
|
NCBI chr 8:42,629,649...42,641,257
|
|
G |
Slc22a5 |
solute carrier family 22 member 5 |
multiple interactions |
ISO |
ziprasidone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] |
CTD |
PMID:30465787 |
|
NCBI chr10:38,008,303...38,035,474
|
|
G |
Sox17 |
SRY-box transcription factor 17 |
decreases localization |
ISO |
ziprasidone results in decreased localization of SOX17 protein |
CTD |
PMID:24154490 |
|
NCBI chr 5:15,016,660...15,022,228
|
|