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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thienopyridine
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Accession:CHEBI:37942 term browser browse the term
Definition:Any organic heterobicyclic compound whose skeleton results from the formal ortho-fusion of any bond of a pyridine with any bond of a thiophene.
Synonyms:related_synonym: thienopyridines



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clopidogrel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases uptake
decreases expression
increases secretion
decreases activity
affects response to substance
ISO
EXP
ABCB1 gene affects the reaction [CYP2C19 gene affects the susceptibility to clopidogrel]
[Aspirin results in increased expression of ABCB1 protein] which results in decreased uptake of clopidogrel
ABCB1 protein results in decreased uptake of clopidogrel
clopidogrel results in decreased expression of ABCB1 mRNA; clopidogrel results in decreased expression of ABCB1 protein
ABCB1 protein results in increased secretion of clopidogrel
clopidogrel results in decreased activity of ABCB1 protein
ABCB1 gene affects the susceptibility to clopidogrel; ABCB1 gene polymorphism affects the susceptibility to clopidogrel; ABCB1 gene SNP affects the susceptibility to clopidogrel
CTD PMID:17112805 PMID:19106083 PMID:19934793 PMID:20180610 PMID:21900887 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5AP mRNA] CTD PMID:19172522 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
JBrowse link
G Arhgap31 Rho GTPase activating protein 31 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of ARHGAP31 mRNA] CTD PMID:19172522 NCBI chr11:62,038,635...62,151,564
Ensembl chr11:62,038,635...62,151,564
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases secretion ISO clopidogrel results in decreased secretion of BDNF protein CTD PMID:21803431 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G C4b complement C4B (Chido blood group) multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of C4B mRNA] CTD PMID:19172522 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
JBrowse link
G Cabin1 calcineurin binding protein 1 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CABIN1 mRNA] CTD PMID:19172522 NCBI chr20:12,893,314...13,015,357
Ensembl chr20:12,893,358...13,015,357
JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CAMKK2 mRNA] CTD PMID:19172522 NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 increases expression ISO clopidogrel results in increased expression of CCL11 mRNA CTD PMID:19155974 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO clopidogrel results in increased expression of CCL4 mRNA CTD PMID:16856976 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO clopidogrel results in increased expression of CCL5 mRNA CTD PMID:16856976 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cd40lg CD40 ligand multiple interactions
decreases expression
ISO clopidogrel inhibits the reaction [Adenosine Diphosphate results in increased expression of CD40LG protein]
clopidogrel results in decreased expression of CD40LG protein
Clopidogrel inhibits the reaction [Adenosine Diphosphate results in increased expression of CD40LG protein]; Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CD40LG protein]
CTD PMID:11297035 PMID:17043144 PMID:19155974 PMID:30537341 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Cd86 CD86 molecule multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 mRNA] CTD PMID:19172522 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Clcn7 chloride voltage-gated channel 7 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CLCN7 mRNA] CTD PMID:19172522 NCBI chr10:14,151,758...14,177,130
Ensembl chr10:14,151,758...14,177,130
JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CSF2RB mRNA] CTD PMID:19172522 NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases oxidation
ISO CYP1A2 protein results in increased oxidation of and results in increased cleavage of Clopidogrel metabolite; furafylline inhibits the reaction [CYP1A2 protein results in increased oxidation of Clopidogrel]
CYP1A2 protein results in increased oxidation of clopidogrel
CTD PMID:19170597 PMID:19812348 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases oxidation
increases expression
multiple interactions
ISO CYP2B6 protein results in increased oxidation of clopidogrel
Clopidogrel results in increased expression of CYP2B6 mRNA
[Clopidogrel co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA
CTD PMID:19812348 PMID:31312845 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
increases oxidation
increases metabolic processing
decreases response to substance
increases response to substance
decreases metabolic processing
affects abundance
affects response to substance
ISO ABCB1 gene affects the reaction [CYP2C19 gene affects the susceptibility to clopidogrel]; CYP2C19 gene affects the reaction [clopidogrel affects the phosphorylation of VASP protein]; CYP2C19 gene affects the susceptibility to [Adenosine Diphosphate co-treated with clopidogrel]; CYP2C19 gene polymorphism results in decreased metabolism of and results in decreased activity of clopidogrel; CYP2C19 gene SNP promotes the reaction [CYP2C19 gene SNP affects the susceptibility to clopidogrel]; CYP2C19 protein results in increased metabolism of and results in increased activity of clopidogrel; CYP2C19 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite; CYP2C9 gene affects the reaction [CYP2C19 gene affects the susceptibility to clopidogrel]; N-3-benzylnirvanol inhibits the reaction [CYP2C19 protein results in increased oxidation of clopidogrel]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of clopidogrel]; P2RY12 gene SNP affects the reaction [CYP2C19 gene SNP affects the susceptibility to clopidogrel]
CYP2C19 protein results in increased metabolism of clopidogrel
CYP2C19 gene polymorphism results in decreased susceptibility to clopidogrel; CYP2C19 gene SNP results in decreased susceptibility to clopidogrel
CYP2C19 gene polymorphism results in increased susceptibility to clopidogrel; CYP2C19 gene SNP results in increased susceptibility to clopidogrel
CYP2C19 gene polymorphism results in decreased metabolism of clopidogrel; CYP2C19 gene SNP results in decreased metabolism of clopidogrel
CYP2C19 gene polymorphism affects the abundance of clopidogrel metabolite
CYP2C19 gene affects the susceptibility to clopidogrel; CYP2C19 gene polymorphism affects the susceptibility to clopidogrel; CYP2C19 gene SNP affects the susceptibility to clopidogrel
CTD PMID:16772608 PMID:17697139 PMID:17900275 PMID:18532997 PMID:18577829 More... NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO CYP2C8 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite CTD PMID:19170597
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO CYP2D6 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite CTD PMID:19170597 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
increases response to substance
increases degradation
affects response to substance
multiple interactions
ISO Clopidogrel results in increased expression of CYP3A4 mRNA
CYP3A4 protein results in increased susceptibility to Clopidogrel
CYP3A4 protein results in increased degradation of Clopidogrel
CYP3A4 gene polymorphism affects the susceptibility to Clopidogrel
CYP3A4 protein results in increased oxidation of and results in increased cleavage of Clopidogrel metabolite; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Clopidogrel]
CTD PMID:16645157 PMID:19170597 PMID:22651985 PMID:31312845 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects response to substance
multiple interactions
ISO CYP3A5 gene polymorphism affects the susceptibility to clopidogrel
CYP3A5 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite
CTD PMID:16754899 PMID:19170597 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of DUSP1 mRNA] CTD PMID:19172522 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Eif1a eukaryotic translation initiation factor 1A multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of EIF1A mRNA] CTD PMID:19172522 NCBI chr18:39,325,695...39,338,043
Ensembl chr18:39,325,202...39,338,696
JBrowse link
G F2 coagulation factor II multiple interactions ISO clopidogrel inhibits the reaction [F2 protein results in increased expression of SELP protein] CTD PMID:17043144 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F2r coagulation factor II (thrombin) receptor affects response to substance ISO F2R gene SNP affects the susceptibility to clopidogrel CTD PMID:16194864 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein] CTD PMID:30537341 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Clopidogrel results in decreased expression of G6PC1 mRNA CTD PMID:31312845 NCBI chr10:86,307,400...86,318,766 JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO clopidogrel results in decreased expression of ICAM1 mRNA; clopidogrel results in decreased expression of ICAM1 protein CTD PMID:19155974 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il10ra interleukin 10 receptor subunit alpha multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of IL10RA mRNA] CTD PMID:19172522 NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061
JBrowse link
G Il13 interleukin 13 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 mRNA] CTD PMID:19172522 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:30537341 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 increases expression ISO clopidogrel results in increased expression of IL4 mRNA CTD PMID:19155974 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
increases response to substance
ISO clopidogrel promotes the reaction [Silicon Dioxide analog results in increased expression of IL6 protein]
clopidogrel results in decreased expression of IL6 mRNA
IL6 protein results in increased susceptibility to clopidogrel
clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:17537833 PMID:19155974 PMID:24793913 PMID:24849676 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions ISO ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Adenosine Diphosphate]; ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Epinephrine]; ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel] CTD PMID:15205592 PMID:16214444 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Itgb3 integrin subunit beta 3 decreases response to substance
affects response to substance
ISO ITGB3 gene SNP results in decreased susceptibility to clopidogrel
ITGB3 gene SNP affects the susceptibility to clopidogrel
CTD PMID:15166949 PMID:19530321 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Ltb4r leukotriene B4 receptor multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of LTB4R1 mRNA] CTD PMID:19172522 NCBI chr15:29,263,126...29,265,716 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK3 mRNA] CTD PMID:19172522 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mccc2 methylcrotonyl-CoA carboxylase subunit 2 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of MCCC2 mRNA] CTD PMID:19172522 NCBI chr 2:31,304,927...31,375,978
Ensembl chr 2:31,304,932...31,375,972
JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO Clopidogrel promotes the reaction [MED1 protein binds to NR1I3 protein alternative form] CTD PMID:31312845 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity EXP clopidogrel results in decreased activity of MMP9 protein CTD PMID:20195827 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Clopidogrel inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of MPO protein]; Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] CTD PMID:20133375 PMID:30537341 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization
multiple interactions
ISO Clopidogrel affects the localization of NR1I3 protein mutant form
[Clopidogrel co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA; Clopidogrel binds to and results in increased activity of NR1I3 protein alternative form; Clopidogrel inhibits the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in decreased activity of NR1I3 protein]; Clopidogrel promotes the reaction [MED1 protein binds to NR1I3 protein alternative form]
CTD PMID:31312845 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Ocln occludin decreases expression
multiple interactions
ISO clopidogrel results in decreased expression of OCLN protein
SB 203580 inhibits the reaction [clopidogrel results in decreased expression of OCLN protein]
CTD PMID:23220562 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G P2ry12 purinergic receptor P2Y12 multiple interactions
increases response to substance
affects response to substance
ISO clopidogrel binds to and results in decreased activity of P2RY12 protein; P2RY12 gene SNP affects the reaction [CYP2C19 gene SNP affects the susceptibility to clopidogrel]
P2RY12 protein results in increased susceptibility to clopidogrel
P2RY12 gene affects the susceptibility to clopidogrel; P2RY12 gene SNP affects the susceptibility to clopidogrel; P2RY12 protein affects the susceptibility to clopidogrel
CTD PMID:11413167 PMID:15933261 PMID:18404433 PMID:18485500 PMID:18577829 More... NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression ISO Clopidogrel results in increased expression of PCK1 mRNA CTD PMID:31312845 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pdgfb platelet derived growth factor subunit B decreases expression ISO clopidogrel results in decreased expression of PDGFB mRNA; clopidogrel results in decreased expression of PDGFB protein CTD PMID:19155974 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pon1 paraoxonase 1 affects response to substance
multiple interactions
ISO PON1 gene polymorphism affects the susceptibility to clopidogrel
PON1 protein results in increased metabolism of and results in increased activity of clopidogrel
CTD PMID:21170047 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of PRKCB mRNA] CTD PMID:19172522 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Ran RAN, member RAS oncogene family multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of RAN mRNA] CTD PMID:19172522 NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276
JBrowse link
G S100a11 S100 calcium binding protein A11 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of S100A11 mRNA] CTD PMID:19172522 NCBI chr 2:179,191,504...179,197,098
Ensembl chr 2:179,191,715...179,197,044
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO Clopidogrel results in decreased expression of SCD mRNA CTD PMID:31312845 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Sele selectin E decreases expression ISO clopidogrel results in decreased expression of SELE mRNA; clopidogrel results in decreased expression of SELE protein CTD PMID:19155974 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Selp selectin P multiple interactions
decreases expression
ISO Clopidogrel inhibits the reaction [F2 protein results in increased expression of SELP protein]; Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of SELP protein]
clopidogrel results in decreased expression of SELP mRNA; clopidogrel results in decreased expression of SELP protein
CTD PMID:17043144 PMID:19155974 PMID:30537341 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
JBrowse link
G Slc3a1 solute carrier family 3 member 1 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of SLC3A1 mRNA] CTD PMID:19172522 NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907
JBrowse link
G Stat2 signal transducer and activator of transcription 2 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of STAT2 mRNA] CTD PMID:19172522 NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967
JBrowse link
G Sucla2 succinate-CoA ligase ADP-forming subunit beta multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of SUCLA2 mRNA] CTD PMID:19172522 NCBI chr15:48,752,356...48,805,495
Ensembl chr15:48,752,312...48,805,138
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 mRNA]
clopidogrel results in increased expression of TGFB1 mRNA
CTD PMID:19155974 PMID:19172522 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO clopidogrel results in increased expression of THBS1; clopidogrel results in increased expression of THBS1 mRNA; clopidogrel results in increased expression of THBS1 protein CTD PMID:9447704 PMID:11875746 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Thrsp thyroid hormone responsive increases expression ISO Clopidogrel results in increased expression of THRSP mRNA CTD PMID:31312845 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Tjp1 tight junction protein 1 decreases expression
multiple interactions
ISO clopidogrel results in decreased expression of TJP1 protein
SB 203580 inhibits the reaction [clopidogrel results in decreased expression of TJP1 protein]
CTD PMID:23220562 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tmem69 transmembrane protein 69 multiple interactions ISO clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of TMEM69 mRNA] CTD PMID:19172522 NCBI chr 5:130,004,888...130,008,466
Ensembl chr 5:130,004,901...130,010,655
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO clopidogrel results in increased expression of TNF mRNA
Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:19155974 PMID:30537341 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression ISO clopidogrel results in increased expression of TP53 mRNA; clopidogrel results in increased expression of TP53 protein CTD PMID:9447704 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions ISO CYP2C19 gene affects the reaction [clopidogrel affects the phosphorylation of VASP protein] CTD PMID:16772608 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
JBrowse link
ticlopidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
decreases expression
ISO
EXP
Ticlopidine results in decreased activity of ABCB11 protein
Ticlopidine results in decreased expression of ABCB11 mRNA
CTD PMID:22646477 PMID:27765674 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity
increases expression
ISO
EXP
Ticlopidine results in decreased activity of ABCC2 protein
Ticlopidine results in increased expression of ABCC2 mRNA
CTD PMID:22646477 PMID:27765674 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Ticlopidine results in increased expression of ABCC3 mRNA CTD PMID:27765674 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression EXP Ticlopidine results in increased expression of ABCC4 mRNA CTD PMID:27765674 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Ticlopidine results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Ticlopidine results in increased activity of CASP3 protein]
CTD PMID:22700542 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO Ticlopidine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Ticlopidine results in increased activity of CASP7 protein]
CTD PMID:22700542 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain increases expression EXP Ticlopidine results in increased expression of COL18A1 protein CTD PMID:11353854 NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO CYP1A2 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite; Ticlopidine inhibits the reaction [CYP1A2 protein results in increased oxidation of 4-amino-2-phenoxymethanesulfonanilide]
Ticlopidine results in decreased activity of CYP1A2 protein
CTD PMID:10759690 PMID:19053182 PMID:19170597 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
decreases activity
ISO Ticlopidine binds to and results in decreased activity of CYP2B6 protein; Ticlopidine inhibits the reaction [CYP2B6 protein affects the metabolism of Endosulfan]; Ticlopidine inhibits the reaction [CYP2B6 protein results in increased metabolism of Bupropion]
Ticlopidine results in decreased activity of CYP2B6 protein
CTD PMID:16855053 PMID:19328226 PMID:23850985 PMID:28887089 PMID:33253783 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
decreases activity
ISO CYP2C19 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite; Ticlopidine inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Ticlopidine inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Ticlopidine inhibits the reaction [CYP2C19 protein results in increased oxidation of 4-amino-2-phenoxymethanesulfonanilide]
Ticlopidine results in decreased activity of CYP2C19 protein
CTD PMID:10759690 PMID:15333513 PMID:15860655 PMID:16049126 PMID:19053182 More... NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO CYP2C8 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite CTD PMID:19170597
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases activity
ISO CYP2D6 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite
Ticlopidine results in decreased activity of CYP2D6 protein
CTD PMID:10759690 PMID:19170597 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases degradation
multiple interactions
increases response to substance
ISO CYP3A4 protein results in increased degradation of Ticlopidine
CYP3A4 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Ticlopidine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Ticlopidine]; Ticlopidine promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]
CTD PMID:19170597 PMID:19299527 PMID:22651985 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO CYP3A5 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite CTD PMID:19170597 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO 1-aminobenzotriazole inhibits the reaction [[Ticlopidine co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Ticlopidine results in increased expression of HMOX1 mRNA] CTD PMID:18227147 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Ticlopidine binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP Ticlopidine results in decreased expression of SLC10A1 mRNA CTD PMID:27765674 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Ticlopidine affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Ticlopidine affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Thbs1 thrombospondin 1 affects expression ISO Ticlopidine affects the expression of THBS1 mRNA CTD PMID:14687031 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Tmprss2 transmembrane serine protease 2 increases expression ISO Ticlopidine results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO Ticlopidine results in increased expression of UGT1A1 mRNA CTD PMID:18227147 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Vegfa vascular endothelial growth factor A decreases activity ISO Ticlopidine results in decreased activity of VEGFA protein CTD PMID:26327247 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      atom 19811
        nonmetal atom 19698
          nitrogen atom 18774
            nitrogen molecular entity 18774
              organonitrogen compound 18552
                organonitrogen heterocyclic compound 17669
                  thienopyridine 79
                    1-(3-amino-4,6-dimethyl-2-thieno[2,3-b]pyridinyl)ethanone 0
                    1-amino-5-(4-morpholinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxylic acid ethyl ester 0
                    2-(1-oxopropylamino)-6-(phenylmethyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 0
                    2-(3-fluoroanilino)-7-hydroxy-5-oxo-4H-thieno[3,2-b]pyridine-3-carbonitrile 0
                    2-(4,5,6,7-tetrahydrothieno[2,3-c]pyridin-3-yl)-1,3-benzothiazole 0
                    2-(4-tert-butylphenyl)sulfinyl-4,6-dimethyl-3-thieno[2,3-b]pyridinamine 0
                    2-(6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-3-yl)-1,3-benzothiazole 0
                    2-Chloroticlopidine 0
                    2-[[(2,5-dichloro-3-thiophenyl)-oxomethyl]amino]-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide 0
                    2-[[1-oxo-2-(2-pyrimidinylthio)ethyl]amino]-6-(phenylmethyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 0
                    2-[[2-(2-cyanophenoxy)-1-oxoethyl]amino]-5,5,7,7-tetramethyl-4,6-dihydrothieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 0
                    2-[[3-(benzenesulfonyl)-1-oxopropyl]amino]-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 0
                    2-acetamido-6-(phenylmethyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid methyl ester 0
                    3-(dimethylaminomethylideneamino)-4-methoxy-2-thieno[2,3-b]pyridinecarboxylic acid ethyl ester 0
                    3-amino-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxylic acid ethyl ester 0
                    3-amino-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxylic acid methyl ester 0
                    3-amino-4,6-dimethyl-N-(thiophen-2-ylmethylideneamino)-2-thieno[2,3-b]pyridinecarboxamide 0
                    3-amino-4-thiophen-2-yl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxylic acid methyl ester 0
                    3-amino-N-cyclopentyl-6-thiophen-2-yl-2-thieno[2,3-b]pyridinecarboxamide 0
                    4-(dimethylamino)-3-[(phenylmethoxyamino)methylideneamino]-2-thieno[2,3-b]pyridinecarboxylic acid ethyl ester 0
                    4-amino-7-hydroxy-2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-b]pyridine-3-carboxylic acid but-2-ynyl ester 0
                    4-hydroxy-3-[2-oxo-3-(thieno[3,2-b]pyridine-2-sulfonylamino)pyrrolidin-1-ylmethyl]benzamidine 0
                    4-oxo-2-(trifluoromethyl)-1H-thieno[3,4-b]pyridine-7-carboxylic acid methyl ester 0
                    5,5,7,7-tetramethyl-2-[[oxo-(4-propan-2-yloxyphenyl)methyl]amino]-4,6-dihydrothieno[2,3-c]pyridine-3-carboxylic acid methyl ester 0
                    5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate + 0
                    6-methyl-2-[(3-methyl-6-oxo-1-cyclohexa-2,4-dienylidene)methylamino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 0
                    7-[(2,6-difluorophenyl)methyl]-2-[4-[(2-methyl-1-oxopropyl)amino]phenyl]-3-[[methyl-(phenylmethyl)amino]methyl]-4-oxo-5-thieno[2,3-b]pyridinecarboxylic acid propan-2-yl ester 0
                    7-hydroxyticlopidine 0
                    LSM-16789 0
                    LSM-19448 0
                    LSM-32991 0
                    N-(6-acetyl-3-cyano-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl)-3,4,5-trimethoxybenzamide 0
                    N-[(3S)-2-oxo-1-(1H-pyrrolo[2,3-c]pyridin-2-ylmethyl)pyrrolidin-3-yl]thieno[3,2-b]pyridine-2-sulfonamide 0
                    N-[3-(1,3-benzothiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]-2,2,2-trifluoroacetamide 0
                    N-[3-(1,3-benzothiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]-2,2-difluoroacetamide 0
                    N-[3-(1,3-benzothiazol-2-yl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl]acetamide 0
                    N-[3-(1,3-benzothiazol-2-yl)-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide 0
                    N-[3-(1,3-benzothiazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]-2,2,2-trifluoroacetamide 0
                    N-[3-(1,3-benzothiazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]-2,2-difluoroacetamide 0
                    N-[3-(1,3-benzothiazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]-4-pentynamide 0
                    N-[3-(1,3-benzoxazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide 0
                    N-[3-(2-benzofuranyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]acetamide 0
                    N-[3-(4-phenyl-2-thiazolyl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide 0
                    N-[3-cyano-6-(3-piperidin-1-ylpropanoyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]naphthalene-1-carboxamide 0
                    N-[6-acetyl-3-(1,3-benzothiazol-2-yl)-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide 0
                    N-\{(3S)-1-[(1-aminoisoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl\}thieno[3,2-b]pyridine-2-sulfonamide 0
                    Tinoridine hydrochloride 0
                    [3-amino-6-thiophen-2-yl-4-(trifluoromethyl)-2-thieno[2,3-b]pyridinyl]-cyclopropylmethanone 0
                    clopidogrel + 64
                    clopidogrel carboxylic acid 0
                    ticlopidine + 79
                    tinoridine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    p-block element atom 19710
                      carbon group element atom 19631
                        carbon atom 19621
                          organic molecular entity 19621
                            organic molecule 19562
                              organic cyclic compound 19356
                                organic heterocyclic compound 18596
                                  organic heteropolycyclic compound 18063
                                    organic heterobicyclic compound 16877
                                      thienopyridine 79
                                        1-(3-amino-4,6-dimethyl-2-thieno[2,3-b]pyridinyl)ethanone 0
                                        1-amino-5-(4-morpholinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxylic acid ethyl ester 0
                                        2-(1-oxopropylamino)-6-(phenylmethyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 0
                                        2-(3-fluoroanilino)-7-hydroxy-5-oxo-4H-thieno[3,2-b]pyridine-3-carbonitrile 0
                                        2-(4,5,6,7-tetrahydrothieno[2,3-c]pyridin-3-yl)-1,3-benzothiazole 0
                                        2-(4-tert-butylphenyl)sulfinyl-4,6-dimethyl-3-thieno[2,3-b]pyridinamine 0
                                        2-(6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-3-yl)-1,3-benzothiazole 0
                                        2-Chloroticlopidine 0
                                        2-[[(2,5-dichloro-3-thiophenyl)-oxomethyl]amino]-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide 0
                                        2-[[1-oxo-2-(2-pyrimidinylthio)ethyl]amino]-6-(phenylmethyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 0
                                        2-[[2-(2-cyanophenoxy)-1-oxoethyl]amino]-5,5,7,7-tetramethyl-4,6-dihydrothieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 0
                                        2-[[3-(benzenesulfonyl)-1-oxopropyl]amino]-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 0
                                        2-acetamido-6-(phenylmethyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid methyl ester 0
                                        3-(dimethylaminomethylideneamino)-4-methoxy-2-thieno[2,3-b]pyridinecarboxylic acid ethyl ester 0
                                        3-amino-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxylic acid ethyl ester 0
                                        3-amino-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxylic acid methyl ester 0
                                        3-amino-4,6-dimethyl-N-(thiophen-2-ylmethylideneamino)-2-thieno[2,3-b]pyridinecarboxamide 0
                                        3-amino-4-thiophen-2-yl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxylic acid methyl ester 0
                                        3-amino-N-cyclopentyl-6-thiophen-2-yl-2-thieno[2,3-b]pyridinecarboxamide 0
                                        4-(dimethylamino)-3-[(phenylmethoxyamino)methylideneamino]-2-thieno[2,3-b]pyridinecarboxylic acid ethyl ester 0
                                        4-amino-7-hydroxy-2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-b]pyridine-3-carboxylic acid but-2-ynyl ester 0
                                        4-hydroxy-3-[2-oxo-3-(thieno[3,2-b]pyridine-2-sulfonylamino)pyrrolidin-1-ylmethyl]benzamidine 0
                                        4-oxo-2-(trifluoromethyl)-1H-thieno[3,4-b]pyridine-7-carboxylic acid methyl ester 0
                                        5,5,7,7-tetramethyl-2-[[oxo-(4-propan-2-yloxyphenyl)methyl]amino]-4,6-dihydrothieno[2,3-c]pyridine-3-carboxylic acid methyl ester 0
                                        5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate + 0
                                        6-methyl-2-[(3-methyl-6-oxo-1-cyclohexa-2,4-dienylidene)methylamino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 0
                                        7-[(2,6-difluorophenyl)methyl]-2-[4-[(2-methyl-1-oxopropyl)amino]phenyl]-3-[[methyl-(phenylmethyl)amino]methyl]-4-oxo-5-thieno[2,3-b]pyridinecarboxylic acid propan-2-yl ester 0
                                        7-hydroxyticlopidine 0
                                        LSM-16789 0
                                        LSM-19448 0
                                        LSM-32991 0
                                        N-(6-acetyl-3-cyano-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl)-3,4,5-trimethoxybenzamide 0
                                        N-[(3S)-2-oxo-1-(1H-pyrrolo[2,3-c]pyridin-2-ylmethyl)pyrrolidin-3-yl]thieno[3,2-b]pyridine-2-sulfonamide 0
                                        N-[3-(1,3-benzothiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]-2,2,2-trifluoroacetamide 0
                                        N-[3-(1,3-benzothiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]-2,2-difluoroacetamide 0
                                        N-[3-(1,3-benzothiazol-2-yl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl]acetamide 0
                                        N-[3-(1,3-benzothiazol-2-yl)-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide 0
                                        N-[3-(1,3-benzothiazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]-2,2,2-trifluoroacetamide 0
                                        N-[3-(1,3-benzothiazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]-2,2-difluoroacetamide 0
                                        N-[3-(1,3-benzothiazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]-4-pentynamide 0
                                        N-[3-(1,3-benzoxazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide 0
                                        N-[3-(2-benzofuranyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]acetamide 0
                                        N-[3-(4-phenyl-2-thiazolyl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide 0
                                        N-[3-cyano-6-(3-piperidin-1-ylpropanoyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]naphthalene-1-carboxamide 0
                                        N-[6-acetyl-3-(1,3-benzothiazol-2-yl)-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide 0
                                        N-\{(3S)-1-[(1-aminoisoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl\}thieno[3,2-b]pyridine-2-sulfonamide 0
                                        Tinoridine hydrochloride 0
                                        [3-amino-6-thiophen-2-yl-4-(trifluoromethyl)-2-thieno[2,3-b]pyridinyl]-cyclopropylmethanone 0
                                        clopidogrel + 64
                                        clopidogrel carboxylic acid 0
                                        ticlopidine + 79
                                        tinoridine 0
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