CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 10H-phenothiazine
Accession: CHEBI:37931
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Definition: The 10H-tautomer of phenothiazine.
Synonyms: related_synonym: 10H-Phenothiazin; Formula=C12H9NS; InChI=1S/C12H9NS/c1-3-7-11-9(5-1)13-10-6-2-4-8-12(10)14-11/h1-8,13H; InChIKey=WJFKNYWRSNBZNX-UHFFFAOYSA-N; SMILES=N1c2ccccc2Sc2ccccc12; dibenzo-1,4-thiazine; phenothiazine
xref: Beilstein:143237; CAS:92-84-2; LINCS:LSM-3324
xref_mesh: MESH:C031637
xref: PMID:25382702; PMID:26661932; Reaxys:143237; Wikipedia:Phenothiazine
cyclic_relationship: is_tautomer_of CHEBI:37933; is_tautomer_of CHEBI:37934; is_tautomer_of CHEBI:37935
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Ar
androgen receptor
affects localization multiple interactions
ISO
phenothiazine analog affects the localization of AR protein phenothiazine analog binds to and results in decreased activity of AR protein; phenothiazine inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]
CTD
PMID:17606915 PMID:33049310
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Brd4
bromodomain containing 4
multiple interactions
ISO
phenothiazine inhibits the reaction [BRD4 protein binds to MED1 protein]
CTD
PMID:26735014
NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539
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Esr1
estrogen receptor 1
multiple interactions
ISO
phenothiazine binds to and results in increased activity of ESR1 protein
CTD
PMID:33049310
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
multiple interactions
ISO
phenothiazine binds to and results in increased activity of ESR2 protein
CTD
PMID:33049310
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
phenothiazine results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Klk1c10
kallikrein 1-related peptidase C10
multiple interactions
ISO
phenothiazine analog affects the reaction [Dihydrotestosterone results in increased expression of KLK3 protein]
CTD
PMID:17606915
NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
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Med1
mediator complex subunit 1
multiple interactions
ISO
phenothiazine inhibits the reaction [BRD4 protein binds to MED1 protein]
CTD
PMID:26735014
NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
phenothiazine binds to and results in increased activity of NR1I2 protein
CTD
PMID:33049310
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
phenothiazine binds to and results in increased activity of PPARG protein
CTD
PMID:33049310
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ar
androgen receptor
multiple interactions
ISO
acetophenazine binds to and results in decreased activity of AR protein
CTD
PMID:17606915
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Alad
aminolevulinate dehydratase
multiple interactions decreases activity
EXP
[Fluphenazine co-treated with diphenyldiselenide] results in decreased activity of ALAD protein Fluphenazine results in decreased activity of ALAD protein
CTD
PMID:19486337
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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Ar
androgen receptor
multiple interactions
ISO
Fluphenazine binds to and results in decreased activity of AR protein
CTD
PMID:17606915
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Cat
catalase
multiple interactions increases activity
EXP
diphenyldiselenide inhibits the reaction [Fluphenazine results in increased activity of CAT protein]
CTD
PMID:19486337
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
decreases activity
ISO
Fluphenazine results in decreased activity of CYP2C9 protein
CTD
PMID:15135088
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2c6v1
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
decreases activity
ISO
Fluphenazine results in decreased activity of CYP2C19 protein
CTD
PMID:15135088
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases activity
ISO
Fluphenazine results in decreased activity of CYP2E1 protein
CTD
PMID:15135088
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases activity
ISO
Fluphenazine results in decreased activity of CYP3A4 protein
CTD
PMID:15135088
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Drd2
dopamine receptor D2
affects binding
ISO
Fluphenazine binds to DRD2 protein
CTD
PMID:17606915
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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Htr2a
5-hydroxytryptamine receptor 2A
affects binding
ISO
Fluphenazine binds to HTR2A protein
CTD
PMID:17606915
NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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Htr2c
5-hydroxytryptamine receptor 2C
affects binding
ISO
Fluphenazine binds to HTR2C protein
CTD
PMID:17606915
NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287
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Ngf
nerve growth factor
multiple interactions
EXP
Fluphenazine inhibits the reaction [NGF protein results in increased uptake of Calcium]
CTD
PMID:1374475
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Prl
prolactin
increases secretion
ISO
Fluphenazine results in increased secretion of PRL protein
CTD
PMID:9989566
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Fluphenazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Tac1
tachykinin, precursor 1
decreases expression
ISO
Fluphenazine results in decreased expression of TAC1 mRNA
CTD
PMID:15845098
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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Tfeb
transcription factor EB
affects localization
ISO
Fluphenazine affects the localization of TFEB protein
CTD
PMID:28366621
NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
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Tmprss2
transmembrane serine protease 2
increases expression
EXP
Fluphenazine results in increased expression of TMPRSS2 mRNA
CTD
PMID:32808185
NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
G
Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
affects metabolic processing decreases methylation
ISO
CYP2C9 gene polymorphism affects the metabolism of Perazine CYP2C9 protein results in decreased methylation of Perazine
CTD
PMID:11026737
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases methylation
ISO
CYP3A4 protein results in decreased methylation of Perazine
CTD
PMID:11026737
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Fmo3
flavin containing dimethylaniline monoxygenase 3
increases oxidation
ISO
FMO3 protein results in increased oxidation of Perazine
CTD
PMID:11026737
NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
G
Ar
androgen receptor
multiple interactions
ISO
periciazine binds to and results in decreased activity of AR protein
CTD
PMID:17606915
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
periciazine results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Ces1d
carboxylesterase 1D
multiple interactions
ISO
Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]
CTD
PMID:20097249
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
ISO EXP
Perphenazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
CTD
PMID:18493746
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Fshb
follicle stimulating hormone subunit beta
decreases expression
EXP
Perphenazine results in decreased expression of FSHB protein
CTD
PMID:6770916
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions decreases activity
ISO
Perphenazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] Perphenazine results in decreased activity of KCNH2 protein
CTD
PMID:21158687 PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Lhb
luteinizing hormone subunit beta
decreases expression
EXP
Perphenazine results in decreased expression of LHB protein
CTD
PMID:6770916
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
G
Prl
prolactin
increases expression
ISO EXP
Perphenazine results in increased expression of PRL protein
CTD
PMID:6770916 PMID:7262630 PMID:17335319
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Perphenazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
G
Tnni3
troponin I3, cardiac type
increases expression
ISO
Perphenazine results in increased expression of TNNI3 protein
CTD
PMID:14742781
NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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Ache
acetylcholinesterase
increases activity
ISO
Prochlorperazine results in increased activity of ACHE protein
CTD
PMID:29614332
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
G
Esr1
estrogen receptor 1
multiple interactions
ISO
Prochlorperazine binds to and results in increased activity of ESR1 protein
CTD
PMID:25752796
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Tfeb
transcription factor EB
affects localization
ISO
Prochlorperazine affects the localization of TFEB protein
CTD
PMID:28366621
NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
G
Abcc1
ATP binding cassette subfamily C member 1
multiple interactions
ISO
[Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein
CTD
PMID:21881209
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
G
App
amyloid beta precursor protein
multiple interactions
ISO
[Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein
CTD
PMID:21881209
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
Triflupromazine results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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